TY  - JOUR
AU  - Garcia, Raul I.
AU  - Gregorich, Steven E.
AU  - Ramos-Gomez, Francisco
AU  - Braun, Patricia A.
AU  - Wilson, Anne
AU  - Albino, Judith
PY  - 2017
TI  - Absence of Fluoride Varnish-Related Adverse Events in Caries Prevention Trials in Young Children, United States
T2  - Preventing Chronic Disease
JO  - Prev Chronic Dis
SP  - E17
VL  - 14
CY  - Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
N2  - INTRODUCTION  Fluoride varnish is an effective prevention intervention for caries in young children. Its routine use in clinical care is supported by meta-analyses and recommended by clinical guidelines, including the US Preventive Services Task Force (B rating). This report is the first prospective systematic assessment of adverse events related to fluoride varnish treatment in young children. METHODS  We determined the incidence of adverse events related to fluoride varnish treatment in 3 clinical trials on the prevention of early childhood caries, conducted under the auspices of the Early Childhood Caries Collaborating Centers, an initiative sponsored by the National Institute of Dental and Craniofacial Research. Each trial incorporated use of fluoride varnish in its protocol and systematically queried all children's parents or legal guardians about the occurrence of acute adverse events after each fluoride varnish treatment. RESULTS  A total of 2,424 community-dwelling, dentate children aged 0 to 5 years were enrolled and followed for up to 3 years. These children received a cumulative total of 10,249 fluoride varnish treatments. On average, each child received 4.2 fluoride varnish treatments. We found zero fluoride varnish-related adverse events. CONCLUSION  Fluoride varnish was not associated with treatment-related adverse events in young children. Our findings support its safety as an effective prevention intervention for caries in young children.
SN  - 1545-1151
UR  - https://doi.org/10.5888/pcd14.160372
DO  - 10.5888/pcd14.160372
ER  - 
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