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Errata: Vol. 63, No. RR-5
In the MMWR Recommendations and Reports "Human Papillomavirus Vaccination: Recommendations of the Advisory Committee on Immunization Practices (ACIP)," an error occurred on page 5. The last sentence of the first full paragraph should read, "Among these six cancers, approximately 21,300 were attributable to HPV16/18 (7,900 [37%] among men and 13,400 [63%] among women) (Table 2)."
In Table 2 on page 6, the average annual numbers of cancers attributable to HPV 16/18 were incorrect. Following is the corrected table:
|
TABLE 2. Average annual number and percentage of cancer cases attributable to human papillomavirus and to HPV 16 and HPV 18, by anatomic site and sex — United States, 2006–2010. |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
Anatomic site |
Average no. of cancers per year |
Cancers attributable |
Cancers attributable |
||||||||
|
Male |
Female |
Both sexes |
% |
Average no.† |
% |
Average no.† |
|||||
|
Male |
Female |
Both sexes |
Male |
Female |
Both sexes |
||||||
|
Cervix |
0 |
11,422 |
11,422 |
91§ |
0 |
10,400 |
10,400 |
67 |
0 |
7,700 |
7,700 |
|
Anus |
1,549 |
2,821 |
4,370 |
91 |
1,400 |
2,600 |
4,000 |
79 |
1,200 |
2,200 |
3,400 |
|
Oropharynx |
9,974 |
2,443 |
12,417 |
72 |
7,200 |
1,800 |
9,000 |
62 |
6,200 |
1,500 |
7,700 |
|
Penis |
1,048 |
0 |
1,048 |
63 |
700 |
0 |
700 |
48 |
500 |
0 |
500 |
|
Vagina |
0 |
735 |
735 |
75 |
0 |
600 |
600 |
57 |
0 |
400 |
400 |
|
Vulva |
0 |
3,168 |
3,168 |
69 |
0 |
2,200 |
2,200 |
49 |
0 |
1,600 |
1,600 |
|
Total |
12,571 |
20,589 |
33,160 |
9,300 |
17,600 |
26,900 |
7,900 |
13,400 |
21,300 |
||
|
Abbreviation: HPV = human papillomavirus. * Sources: Data come from population-based cancer registries that participate in the National Program of Cancer Registries and/or the Surveillance, Epidemiology, and End Results Program, and meet criteria for high data quality. Cancer Registry Data are from all states meeting USCS publication criteria (http://www.cy118119.com/cancer/npcr/uscs/technical_notes/criteria.htm) for all years 2006–2010 and cover approximately 94.8% of the US population. In order to determine those cancers most likely to be HPV-associated, the following additional criteria were applied to the NPCR/SEER data: all cancers were microscopically confirmed; cervical cancers were limited by histology to carcinomas only (ICD-O-3 histology codes 8010–8671, 8940–8941); all other cancer sites were limited by histology to squamous cell carcinomas only (ICD-O-3 histology codes 8050–8084,8120-8131); oropharyngeal cancers were defined as having the following ICD-O-3 site codes: 19, 24, 28, 90–91, 98–99, 102, 108–109, 140, 142, and 148. † The estimated number of HPV-attributable or HPV 16/18-attributable cancers was calculated by multiplying the HPV-associated cancer counts by the percentage of each cancer attributable to HPV or HPV16/18. Estimates rounded to the nearest 100. § Although HPV is accepted to be a necessary factor in the causal pathway to invasive cervical cancer, HPV is not always detected in tumor specimens from women who receive a diagnosis of invasive cervical cancer due to a variety of reasons, including misclassification of tissue specimens as cervix, quality of tissue specimens, assay sensitivity, and a small proportion of HPV-negative, cervical cancers. |
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