TY  - JOUR
AB  - Unprecedented by number of casualties and socio-economic burden occurring worldwide, the coronavirus disease 2019 (Covid-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the worst health crisis of this century In order to develop adequate countermeasures against Covid-19, identification and structural characterization of suitable antiviral targets within the SARS-CoV-2 protein repertoire is urgently needed The nucleocapsid phosphoprotein (N) is a multifunctional and highly immunogenic determinant of virulence and pathogenicity, whose main functions consist in oligomerizing and packaging the single-stranded RNA (ssRNA) viral genome Here we report the structural and biophysical characterization of the SARS-CoV-2 N C-terminal domain (CTD), on which both N homo-oligomerization and ssRNA binding depend Crystal structures solved at 1 44 �?and 1 36 �?resolution describe a rhombus-shape N CTD dimer, which stably exists in solution as validated by size-exclusion chromatography coupled to multi-angle light scattering and analytical ultracentrifugation Differential scanning fluorimetry revealed moderate thermal stability and a tendency towards conformational change Microscale thermophoresis demonstrated binding to a 7-bp SARS-CoV-2 genomic ssRNA fragment at micromolar affinity Furthermore, a low-resolution preliminary model of the full-length SARS-CoV N in complex with ssRNA, obtained by cryo-electron microscopy, provides an initial understanding of self-associating and RNA binding functions exerted by the SARS-CoV-2 N
AU  - Zinzula, Luca
AU  - Basquin, Jerome
AU  - Bohn, Stefan
AU  - Beck, Florian
AU  - Klumpe, Sven
AU  - Pfeifer, Günter Nagy
AU  - Istv֙n, Bracher
AU  - Andreas, Hartl
AU  - F. Ulrich, Baumeister
AU  - Wolfgang
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2
T2  - Biochemical and Biophysical Research Communications
TI  - High-resolution structure and biophysical characterization of the nucleocapsid phosphoprotein dimerization domain from the Covid-19 severe acute respiratory syndrome coronavirus 2
UR  - https://doi.org/10.1016/j.bbrc.2020.09.131
ID  - 7793225
ER  - 

TY  - JOUR
AB  - Covid-19 emergency has forced hospitals to face enormous organizational challenges in order to implement solutions to minimize the impact of the infection and guarantee at the same time the quality of health services provided and the safety of patients and health workers ULSS 6 Euganea - Health Trust (District of Padua) has defined four levels of risk for Hospital Units (from the highest to the lowest risk: Red, Yellow, Green and White) based on the following parameters: type of patients hospitalized (SARS-CoV-2 positive, Covid-like, negative), type of health services provided, time of assistance and care for hospitalized patient
AU  - Zilli, E.
AU  - Madia, A.
AU  - Giuriato, P.
AU  - Bonaldo, D.
AU  - Napolitano, R. C.
AU  - Callegaro, R. G.
AU  - Fioretto, M.
AU  - Arseni, A.
AU  - Benini, P.
AU  - Scibetta, D.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Risk stratification for the safety of patients and hospital health workers during Covid-19 emergency
T2  - European Journal of Public Health
TI  - Risk stratification for the safety of patients and hospital health workers during Covid-19 emergency
UR  - https://doi.org/10.1093/eurpub/ckaa165.208
ID  - 7792918
ER  - 

TY  - JOUR
AB  - OBJECTIVE: The chest computed tomography (CT) features of coronavirus disease 2019 (COVID-19) and Streptococcus pneumoniae pneumonia (S. pneumoniae pneumonia) were compared to provide further evidence for the differential imaging diagnosis of patients with these two types of pneumonia. METHODS: Clinical information and chest CT data of 149 COVID-19 patients between January 9, 2020 and March 15, 2020 and 97 patients with S. pneumoniae pneumonia between January 23, 2011 and March 18, 2020 in Zhongnan Hospital of Wuhan University were retrospectively analyzed. In addition, CT features were comparatively analyzed. RESULTS: According to the chest CT images, the probability of lung segmental and lobar pneumonia in S. pneumoniae pneumonia was higher than that in COVID-19(P0.001); the probabilities of ground-glass opacity (GGO), the “crazy paving�?sign, and abnormally thickened interlobular septa in COVID-19 were higher than those in S. pneumoniae pneumonia(P�?�?.005, P0.001, P0.001, respectively); and the probabilities of consolidation lesions, bronchial wall thickening, centrilobular nodules, and pleural effusion in S. pneumoniae pneumonia were higher than those in COVID-19 (P0.001, P�?�?.001, P�?�?.003, P�?�?.001, respectively). CONCLUSION: The findings of GGO, the crazy paving sign, and abnormally thickened interlobular septa on chest CT were significantly higher in COVID-19 than S. pneumoniae pneumonia. The most important differential points on chest CT signs between COVID-19 and S. pneumoniae pneumonia were whether disease lesions were distributed in entire lung lobes and segments and whether the crazy paving sign, interlobular septal thickening, and consolidation lesions were found.
AN  - PMC7536592
AU  - Zhou, Jun
AU  - Liao, Xingnan
AU  - Cao, Jia
AU  - Ling, Gonghao
AU  - Xun
AU  - Long, QingYun
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.clinimag.2020.09.012
DP  - NLM
J2  - Clin Imaging
KW  - Coronavirus disease 2019 (COVID-19)
Streptococcus pneumoniae
Computed tomography
Differential diagnosis
LA  - eng
N1  - PMC7536592[pmcid]
S0899-7071(20)30357-0[PII]
PY  - 2020
SN  - 0899-7071
1873-4499
ST  - Differential diagnosis between the coronavirus disease 2019 and Streptococcus pneumoniae pneumonia by thin-slice CT features
T2  - Clinical Imaging
TI  - Differential diagnosis between the coronavirus disease 2019 and Streptococcus pneumoniae pneumonia by thin-slice CT features
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536592/
ID  - 7790659
ER  - 

TY  - JOUR
AB  - AIM: Angiotensin-converting enzyme 2 (ACE 2) is the binding domain for severe acute respiratory syndrome coronavirus (SARS-CoV) and SARSCoV-2. Some antihypertensive drugs affect ACE2 expression or activity (ACE inhibitors and Angiotensin II Receptor Blockers (ARBs)), suggesting use of other hypertensives might be preferable, such as calcium channel blockers (CCBs). Given the limited evidence, the International Society of Hypertension does not support such a policy. METHODS: We used a Mendelian randomization study to obtain unconfounded associations of anti-hypertensives, instrumented by published genetic variants in genes regulating target proteins of these drugs, with immune (lymphocyte and neutrophil percentage) and inflammatory (tumor necrosis factor alpha (TNF-��)) markers in the largest available genome wide association studies. RESULTS: Genetically predicted effects of ACE inhibitors increased lymphocyte percentage (0.78, 95% confidence interval (CI) 0.35, 1.22), decreased neutrophil percentage (-0.64, 95% CI -1.09, -0.20) and possibly lowered TNF-�� (-4.92, 95% CI -8.50, -1.33). CCBs showed a similar pattern for immune function (lymphocyte percentage 0.21, 95% CI 0.05 to 0.36; neutrophil percentage -0.23, 95% CI -0.39 to -0.08) but had no effect on TNF-��, as did potassium-sparing diuretics and aldosterone antagonists, and vasodilator antihypertensives. ARBs and other classes of hypertensives had no effect on immune function or TNF-��. CONCLUSION: Varying effects of different classes of anti-hypertensives on immune and inflammatory markers do not suggest antihypertensive use based on their role in ACE2 expression, but instead suggests investigation of the role of antihypertensives in immune function and inflammation might reveal important information that could optimize their use in SARSCoV-2.
AD  - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
City University of New York, School of Public Health and Health policy, New York, NY, USA.
AN  - 33025652
AU  - Zhao, J. V.
AU  - Schooling, C. M.
AU  - Leung, G. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/bcp.14572
DP  - NLM
ET  - 2020/10/08
J2  - British journal of clinical pharmacology
KW  - ACE inhibitor
immune function
inflammation
LA  - eng
N1  - 1365-2125
Zhao, Jie V
Orcid: 0000-0002-1564-0057
Schooling, C Mary
Leung, Gabriel M
Journal Article
England
Br J Clin Pharmacol. 2020 Oct 6. doi: 10.1111/bcp.14572.
PY  - 2020
SN  - 0306-5251
ST  - Using genetics to understand the role of antihypertensive drugs modulating angiotensin-converting enzyme in immune function and inflammation
T2  - British journal of clinical pharmacology
TI  - Using genetics to understand the role of antihypertensive drugs modulating angiotensin-converting enzyme in immune function and inflammation
ID  - 7790690
ER  - 

TY  - JOUR
AU  - Zhao, Hailin
AU  - Davies, Roger
AU  - Ma, Daqing
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Potential therapeutic value of dexmedetomidine in COVID-19 patients admitted to ICU
T2  - British Journal of Anaesthesia
TI  - Potential therapeutic value of dexmedetomidine in COVID-19 patients admitted to ICU
UR  - https://doi.org/10.1016/j.bja.2020.09.031
ID  - 7793222
ER  - 

TY  - JOUR
AB  - Background: Early observational studies suggested that the use of the renin angiotensin system (RAS) inhibitors, specifically angiotensin converting enzyme inhibitors or angiotensin receptor blockers, may increase the risk of infection with SARS-CoV-2 and adversely affect the prognosis or survival of infected patients. To explore the impact of RAS inhibitor use on the risk of SARS-CoV-2 infection and the prognosis of SARS-CoV-2 infected patients, from all published studies. Methods and Findings: A systematic review and meta-analysis of the use of RAS inhibitors in relation to infection with SARS-CoV-2 and/or the severity and mortality associated with COVID-19 was conducted. English language bibliographic databases PubMed, Web of Science, OVID Embase, Scopus, MedRxiv, BioRxiv, searched from Jan 1st, 2020 to July 20th, 2020. 58 observational studies (69,200 COVID-19 patients and 3,103,335 controls) were included. There was no difference in the susceptibility to SARS-CoV-2 infection between RAS inhibitor users and non-users (unadjusted OR 1.05, 95% CI 0.90 to 1.21), (adjusted OR 0.93, 95% CI 0.85 to 1.02), (adjusted HR 1.07, 95% CI 0.87 to 1.31). There was no significant difference in the severe Covid-19 case rate between RAS inhibitor users and non-users (unadjusted OR 1.05, 95% CI 0.81 to 1.36), (adjusted OR 0.76, 95% CI 0.52 to 1.12), or in mortality due to COVID-19 between RAS inhibitor users and non-users (unadjusted OR 1.12, 95% CI 0.88 to 1.44), (adjusted OR 0.97, 95% CI 0.77 to 1.23), (adjusted HR 0.62, 95% CI 0.34 to 1.14). Conclusions: In the most comprehensive analysis of all available data to date, treatment with RAS inhibitors was not associated with increased risk of infection, severity of disease, or mortality due to COVID-19. The best available evidence suggests that these treatments should not be discontinued on the basis of concern about risk associated with COVID-19.Competing Interest StatementBW has received honoraria for lectures on the treatment of hypertension and cardiovascular risk from Daiichi Sankyo, Servier, Pfizer, Novartis and Menarini; no other relationships or activities that could appear to have influenced the submitted work.Funding StatementBW is supported by the NIHR University College London Biomedical Research Centre. YZ is supported by the National Nature Science Foundation of China (81670377) and the Shanghai Excellent Young Scholars Program (2017YQ065).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NAAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Yesnot applicable
AU  - Zhang, Yi
AU  - Yu, Shikai
AU  - Xu, Yawei
AU  - Williams, Bryan
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206375
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206375
ST  - Renin Angiotensin System Inhibition and Susceptibility and Outcomes from COVID-19: A Systematic Review and Meta-analysis of 69,200 COVID-19 Patients (preprint)
T2  - medRxiv
TI  - Renin Angiotensin System Inhibition and Susceptibility and Outcomes from COVID-19: A Systematic Review and Meta-analysis of 69,200 COVID-19 Patients (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206375.abstract
ID  - 7794755
ER  - 

TY  - JOUR
AB  - Objective Traditional Chinese medicine plays a significant role in the treatment of the pandemic of coronavirus disease 2019 (COVID-19) Tanreqing Capsule (TRQC) was used in the treatment of COVID-19 patients in the Shanghai Public Health Clinical Center This study aimed to investigate the clinical efficacy of TRQC in the treatment of COVID-19 Methods A retrospective cohort study was conducted on 82 patients who had laboratory-confirmed mild and moderate COVID-19;patients were treated with TRQC in one designated hospital The treatment and control groups consisted of 25 and 57 cases, respectively The treatment group was given TRQC orally three times a day, three pills each time, in addition to conventional Western medicine treatments which were also administered to the control group The clinical efficacy indicators, such as the negative conversion time of pharyngeal swab nucleic acid, the negative conversion time of fecal nucleic acid, the duration of negative conversion of pharyngeal-fecal nucleic acid, and the improvement in the level of immune indicators such as T-cell subsets (CD3, CD4 and CD45) were monitored Results COVID-19 patients in the treatment group, compared to the control group, had a shorter negative conversion time of fecal nucleic acid (4 vs 9 days, P = 0 047) and a shorter interval of negative conversion of pharyngeal-fecal nucleic acid (0 vs 2 days, P = 0 042) The level of CD3+ T cells increased in the treatment group compared to the control group ([317 09 �u 274 39] vs [175 02 �u 239 95] counts/μL, P = 0 030) No statistically significant differences were detected in the median improvement in levels of CD4+ T cells (173 vs 107 counts/μL, P = 0 208) and CD45+ T cells (366 vs 141 counts/μL, P = 0 117) between the treatment and control groups Conclusion Significant reductions in the negative conversion time of fecal nucleic acid and the duration of negative conversion of pharyngeal-fecal nucleic acid were identified in the treatment group as compared to the control group, illustrating the potential therapeutic benefits of using TRQC as a complement to conventional medicine in patients with mild and moderate COVID-19 The underlying mechanism may be related to the improved levels of the immune indicator CD3+ T cells
AU  - Zhang, Xing
AU  - Xue, Yan
AU  - Chen, Xuan
AU  - Wu, Jia-min
AU  - Su, Zi-jian
AU  - Sun, Meng
AU  - Liu, Lu-jiong
AU  - Zhang, Yi-bao
AU  - Zhang, Yi-le
AU  - Xu, Gui-hua
AU  - Shi, Miao-yan
AU  - Song, Xiu-ming
AU  - Lu, Yun-fei
AU  - Chen, Xiao-rong
AU  - Zhang, Wei
AU  - Chen, Qi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19: A retrospective cohort study
T2  - Journal of Integrative Medicine
TI  - Effects of Tanreqing Capsule on the negative conversion time of nucleic acid in patients with COVID-19: A retrospective cohort study
UR  - https://doi.org/10.1016/j.joim.2020.10.002
ID  - 7793122
ER  - 

TY  - JOUR
AD  - Robert Wood Johnson University Hospital Somerset, 110 Rehill Ave., Somerville, NJ, 08876-2598, USA. neurohealer@yahoo.com.
Robert Wood Johnson University Hospital Somerset, 110 Rehill Ave., Somerville, NJ, 08876-2598, USA.
AN  - 33025544
AU  - Zhang, T.
AU  - Hirsh, E.
AU  - Zandieh, S.
AU  - Rodricks, M. B.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s12028-020-01119-7
DP  - NLM
ET  - 2020/10/08
J2  - Neurocritical care
LA  - eng
N1  - 1556-0961
Zhang, Tianshu
Orcid: 0000-0002-1827-7388
Hirsh, Ellen
Zandieh, Shadi
Rodricks, Michael B
Journal Article
United States
Neurocrit Care. 2020 Oct 6. doi: 10.1007/s12028-020-01119-7.
PY  - 2020
SN  - 1541-6933
ST  - COVID-19-Associated Acute Multi-infarct Encephalopathy in an Asymptomatic CADASIL Patient
T2  - Neurocritical care
TI  - COVID-19-Associated Acute Multi-infarct Encephalopathy in an Asymptomatic CADASIL Patient
ID  - 7790695
ER  - 

TY  - JOUR
AB  - Evaluation of airborne infection risk with spatial and temporal resolutions is indispensable for the design of proper interventions fighting infectious respiratory diseases (e.g., COVID-19), because the distribution of aerosol contagions is both spatially and temporally non-uniform. However, the well-recognized Wells-Riley model and modified Wells-Riley model (i.e., the rebreathed-fraction model) are limited to the well-mixed condition and unable to evaluate airborne infection risk spatially and temporally, which could result in overestimation or underestimation of airborne infection risk. This study proposes a dilution-based evaluation method for airborne infection risk. The method proposed is benchmarked by the Wells-Riley model and modified Wells-Riley model, which indicates that the method proposed is a thorough expansion of the Wells-Riley model for evaluation of airborne infection risk with both spatial and temporal resolutions. Experiments in a mock hospital ward also demonstrate that the method proposed effectively evaluates the airborne infection risk both spatially and temporally.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe work described in this paper is supported by the National Natural Science Foundation of China (Project No. 51878585). The help of Ms. Yalin Lu in the experiments is highly appreciated.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No IRB is necessary.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data are available in the manuscript.
AU  - Zhang, Sheng
AU  - Lin, Zhang
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206391
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206391
ST  - Dilution-based Evaluation of Airborne Infection Risk - Thorough Expansion of Wells-Riley Model (preprint)
T2  - medRxiv
TI  - Dilution-based Evaluation of Airborne Infection Risk - Thorough Expansion of Wells-Riley Model (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206391.abstract
ID  - 7794742
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has caused an unprecedented human and health crisis And the shortage of protective equipment, especially the personal protective disposable surgical masks, has been a great challenge Here, we developed an effective and simple scheme to prolong the lifetime of disposable surgical masks without changing their current structure, which is beneficial to solve the shortage of personal masks After electrifying the meltblown PP filter by the new-developed single-electrode-based sliding triboelectric nanogenerator (TENG) charge replenishment (NGCR) technology, the processed filter is bipolar charged and has a filtration efficiency beyond 95% for the particulate matter (PM) ranging from PM0 3 to PM10 0 Further, we demonstrate the 80 ��C dry heating is an effective decontamination method This method is compatible with single-electrode-based sliding TENG charge replenishment technology The 80 ��C dry heating and the NGCR technology can make up an effective regeneration procedure for the mask Even after ten cycles of simulated 4-hour wearing process and such regeneration procedure, the filtration efficiency of the disposable surgical masks PM0 3 is still higher than 95%
AU  - Zhang, Ruichao
AU  - Xu, Qi
AU  - Bai, Suo
AU  - Hai, Jun
AU  - Cheng, Li
AU  - Qin, Yong
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Enhancing the filtration efficiency and wearing time of disposable surgical masks using TENG technology
T2  - Nano Energy
TI  - Enhancing the filtration efficiency and wearing time of disposable surgical masks using TENG technology
UR  - https://doi.org/10.1016/j.nanoen.2020.105434
ID  - 7793088
ER  - 

TY  - JOUR
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: robert.coffey@vumc.org.
AN  - 33022277
AU  - Zhang, Q.
AU  - Jeppesen, D. K.
AU  - Higginbotham, J. N.
AU  - Franklin, J. L.
AU  - Crowe, J. E., Jr.
AU  - Coffey, R. J.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1053/j.gastro.2020.09.042
DP  - NLM
ET  - 2020/10/07
J2  - Gastroenterology
LA  - eng
N1  - 1528-0012
Zhang, Qin
Jeppesen, Dennis K
Higginbotham, James N
Franklin, Jeffrey L
Crowe, James E Jr
Coffey, Robert J
Journal Article
United States
Gastroenterology. 2020 Oct 3:S0016-5085(20)35227-6. doi: 10.1053/j.gastro.2020.09.042.
PY  - 2020
SN  - 0016-5085
ST  - ACE2-containing extracellular vesicles and exomeres bind the SARS-CoV-2 spike protein
T2  - Gastroenterology
TI  - ACE2-containing extracellular vesicles and exomeres bind the SARS-CoV-2 spike protein
ID  - 7790972
ER  - 

TY  - JOUR
AB  - Health rumors often mislead people and cause adverse health behaviors. Especially during a public health emergency, health rumors may result in severe consequences for people's health and risk governance. Insight into how these rumors form and harm people's health behavior is critical for assisting people in establishing scientific health cognition and to enhance public health emergency responses. Using the case study with interview data of a salient purchase craze led by a health rumor during the COVID-19 outbreak in China, this article aimed to illustrate the process of how a piece of information becomes a health rumor. Furthermore, we identify factors that cause people to believe rumors and conduct behavior that leads to a purchase craze. Results show that a public misunderstanding of the unique psychology of uncertainty, cultural and social cognition, and conformity behavior jointly informs people's beliefs in rumors and further causes purchase craze behavior. We developed a simplified model to demonstrate how an ordinary news report can lead to a rumor. Based on this model, some implications of effective health communication are suggested for managing rumors.
AD  - School of Public Administration, Jilin University, Changchun 130012, China.
Institute of Urban Governance, Shenzhen University, Shenzhen 518060, China.
Department of Social Psychology, Nankai University, Tianjin 300350, China.
School of International and Public Affairs, Shanghai Jiao Tong University, Shanghai 200030, China.
AN  - 33023103
AU  - Zhang, L.
AU  - Chen, K.
AU  - Jiang, H.
AU  - Zhao, J.
C1  - 10/7/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.3390/ijerph17197213
DP  - NLM
ET  - 2020/10/08
IS  - 19
J2  - International journal of environmental research and public health
KW  - Covid-19
health communication
health perception
health rumor
public health emergency
risk governance
LA  - eng
N1  - 1660-4601
Zhang, Liwei
Chen, Kelin
Orcid: 0000-0002-8066-2826
Jiang, He
Zhao, Ji
Journal Article
Switzerland
Int J Environ Res Public Health. 2020 Oct 2;17(19):E7213. doi: 10.3390/ijerph17197213.
PY  - 2020
SN  - 1660-4601
ST  - How the Health Rumor Misleads People's Perception in a Public Health Emergency: Lessons from a Purchase Craze during the COVID-19 Outbreak in China
T2  - International journal of environmental research and public health
TI  - How the Health Rumor Misleads People's Perception in a Public Health Emergency: Lessons from a Purchase Craze during the COVID-19 Outbreak in China
VL  - 17
ID  - 7790927
ER  - 

TY  - JOUR
AB  - Convalescent plasma (CP) transfusion has been indicated as a promising therapy in the treatment for other emerging viral infections. However, the quality control of CP and individual variation in patients in different studies make it rather difficult to evaluate the efficacy and risk of CP therapy for coronavirus disease 2019 (COVID-19). We aimed to explore the potential efficacy of CP therapy, and to assess the possible factors associated with its efficacy. We enrolled eight critical or severe COVID-19 patients from four centers. Each patient was transfused with 200-400 mL of CP from seven recovered donors. The primary indicators for clinical efficacy assessment were the changes of clinical symptoms, laboratory parameters, and radiological image after CP transfusion. CP donors had a wide range of antibody levels measured by serology tests which were to some degree correlated with the neutralizing antibody (NAb) level. No adverse events were observed during and after CP transfusion. Following CP transfusion, six out of eight patients showed improved oxygen support status; chest CT indicated varying degrees of absorption of pulmonary lesions in six patients within 8 days; the viral load was decreased to a negative level in five patients who had the previous viremia; other laboratory parameters also tended to improve, including increased lymphocyte counts, decreased C-reactive protein, procalcitonin, and indicators for liver function. The clinical efficacy might be associated with CP transfusion time, transfused dose, and the NAb levels of CP. This study indicated that CP might be a potential therapy for severe patients with COVID-19.
AD  - National Engineering Research Center of Immunological, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, P.R. China.
State Key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical University, Chongqing, P.R. China.
Institute of Blood Transfusion, Chongqing Blood Center, Chongqing, P.R. China.
Chongqing Public Health Medical Central, Chongqing, P.R. China.
Division of HIV/AIDS and Sex-transmitted Virus Vaccines, Institute for Biological Product Control, National Institutes for Food and Drug Control, Beijing, P.R. China.
Chongqing University Three Gorges Hospital & Chongqing Three Gorges Central Hospital, Chongqing, P.R. China.
Affiliated Hospital of North Sichuan Medical College, Nanchong, P.R. China.
Yongchuan Hospital of Chongqing Medical University, Chongqing, P.R. China.
Institute of Blood Transfusion, Chongqing Blood Center, Chongqing, P.R. China. maoweicqbc@163.com.
Chongqing Public Health Medical Central, Chongqing, P.R. China. yaokaichen@hotmail.com.
National Engineering Research Center of Immunological, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, P.R. China. qmzou2007@163.com.
AN  - 33024082
AU  - Zeng, H.
AU  - Wang, D.
AU  - Nie, J.
AU  - Liang, H.
AU  - Gu, J.
AU  - Zhao, A.
AU  - Xu, L.
AU  - Lang, C.
AU  - Cui, X.
AU  - Guo, X.
AU  - Zhou, C.
AU  - Li, H.
AU  - Guo, B.
AU  - Zhang, J.
AU  - Wang, Q.
AU  - Fang, L.
AU  - Liu, W.
AU  - Huang, Y.
AU  - Mao, W.
AU  - Chen, Y.
AU  - Zou, Q.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41392-020-00329-x
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
Zeng, Hao
Wang, Dongfang
Nie, Jingmin
Liang, Haoyu
Gu, Jiang
Orcid: 0000-0001-8035-4551
Zhao, Anne
Xu, Lixin
Lang, Chunhui
Cui, Xiaoping
Guo, Xiaolan
Zhou, Changlong
Li, Haibo
Guo, Bin
Zhang, Jinyong
Wang, Qiang
Fang, Li
Liu, Wen
Huang, Yishan
Mao, Wei
Chen, Yaokai
Orcid: 0000-0002-3229-0108
Zou, Quanming
Journal Article
England
Signal Transduct Target Ther. 2020 Oct 6;5(1):219. doi: 10.1038/s41392-020-00329-x.
PY  - 2020
SN  - 2059-3635
SP  - 219
ST  - The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series
T2  - Signal transduction and targeted therapy
TI  - The efficacy assessment of convalescent plasma therapy for COVID-19 patients: a multi-center case series
VL  - 5
ID  - 7790845
ER  - 

TY  - JOUR
AB  - Background The prolonged lockdown related to COVID-19 pandemic determined disruption of lifestyle and social isolation Methods To assess the mental health status of Relapsing-Remitting Multiple Sclerosis (RRMS) patients regularly followed at the MS centre of Catania (Italy) and returning to work after the easing of lockdown during COVID-19 pandemic Then, to identify any variables associated to psychological distress RRMS patients returning to work during the COVID-19 pandemic were invited to answer a telephonic interview consisting of the administration of the Short-Screening-Scale for DSM IV (SSS-DSM-IV), the Depression, Anxiety, Stress Scale- 21 (DASS-21) and the Insomnia Severity Index (ISI) Other information was extracted from electronic medical records Results Valid and complete interviews were obtained from 432 patients (response rate 64 3%) Out of them, 277 (64 1%) were female, mean age 40 4 (SD 12 4) years One-hundred thirty-seven (31 7%) RRMS patients received a score �? at the SSS-DSM-IV, indicating clinically significant PTSD-like symptoms About DASS-21, moderate-to-severe anxiety was reported by 210 RRMS patients (48 6%), moderate-to-severe depression, and moderate-to-severe stress were respectively reported by 95 (22%) and 220 (50 9%) RRMS patients Insomnia was reported by 128 patients (29 6%) Factors associated with major severity of symptoms were: marital status, previous diagnosis of mood disorders, switching/starting Disease-Modifying Therapies in the last 12 months, and a higher level of disability measured with Expanded Disability Status Scale (for all, p&amp;lt;0 05) Conclusions Our findings highlight the need to provide psychological support to MS patients facing the delicate phase of returning to work and to normal activities
AU  - Zanghì, Aurora D.
AU  - Amico, Emanuele
AU  - Luca, Maria
AU  - Ciaorella, Marco
AU  - Basile, Lucia
AU  - Patti, Francesco
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Mental health status of Relapsing-Remitting Multiple Sclerosis Italian patients returning to work soon after the easing of lockdown during COVID-19 pandemic: a monocentric experience
T2  - Multiple Sclerosis and Related Disorders
TI  - Mental health status of Relapsing-Remitting Multiple Sclerosis Italian patients returning to work soon after the easing of lockdown during COVID-19 pandemic: a monocentric experience
UR  - https://doi.org/10.1016/j.msard.2020.102561
ID  - 7793089
ER  - 

TY  - JOUR
AB  -: Correctional settings can be vectors of infectious diseases due to overcrowding, unsanitary living conditions, and very little capacity to engage in social distancing. In the US, COVID-19 outbreaks were first identified in the New York City and Cook County jails, with infection rates far exceeding community rates. Each day new cases are being identified across the country in correctional facilities. People who are incarcerated are at increased risk of experiencing severe COVID-19 symptoms because of the increased prevalence of other underlying illnesses. Jails and prisons have begun initiating facility-level policies to help stop the spread of COVID-19. As a result, correctional agencies have reoriented staff to stem transmission in their facilities. This could translate into limited resources for other programming such as medications for opioid use disorder (MOUD) programs. In this commentary, we highlight risk mitigation practices for delivering MOUD in correctional settings during COVID-19 and note how to ensure quality of care while still preparing for the possibility of future pandemics.
AD  - College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR (NZ); School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC (LBR).
AN  - 33021554
AU  - Zaller, N.
AU  - Brinkley-Rubinstein, L.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1097/adm.0000000000000758
DP  - NLM
ET  - 2020/10/07
J2  - Journal of addiction medicine
LA  - eng
N1  - 1935-3227
Zaller, Nickolas
Brinkley-Rubinstein, Lauren
Journal Article
United States
J Addict Med. 2020 Oct 5. doi: 10.1097/ADM.0000000000000758.
PY  - 2020
SN  - 1932-0620
ST  - MOUD Provision in Correctional Settings During Time of COVID-19: Prevention and Solutions
T2  - Journal of addiction medicine
TI  - MOUD Provision in Correctional Settings During Time of COVID-19: Prevention and Solutions
ID  - 7791021
ER  - 

TY  - JOUR
AB  - The problem of diminishing resources on our plant is now getting due attention from the governments as well as scientists around the world The transition from a linear economy to a circular economy (CE) is now among the top priorities This article discusses the implementation of the circular economy paradigm in Poland through the analysis of the existing and planned mechanisms, and actions taken by the Polish government which can be replicated by other young European countries Further, the article discusses the direction of change and projected measures planned by the Polish government to improve the quality of municipal solid waste management In this context, profitability analysis is carried out for two methods of waste processing (incineration and torrefaction) intended for small municipalities and settlements in which district heating and trading of generated electricity are not feasible The results of the analysis shows that torrefaction is clearly a more desirable waste processing option as a step towards the implementation of CE for civic society in the urban context, as well as profitability, in comparison to incineration The analysis accounts for several scenarios before the lockdown caused due to the COVID-19 pandemic and after it was lifted
AU  - Zaleski, Przemysław Chawla
AU  - Yash
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Circular Economy in Poland: Profitability Analysis for Two Methods of Waste Processing in Small Municipalities
T2  - Energies
TI  - Circular Economy in Poland: Profitability Analysis for Two Methods of Waste Processing in Small Municipalities
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813284
ID  - 7793324
ER  - 

TY  - JOUR
AD  - Lyon Arboretum, University of Hawai'i at Mānoa, Honolulu, HI, United States
School of Plant and Environmental Sciences, Virginia Tech, Blacksburg, VA, United States
Department of Geography and Environmental Systems, University of Maryland, Baltimore County, Baltimore, MD, United States
AU  - Zahawi, R. A.
AU  - Reid, J. L.
AU  - Fagan, M. E.
C1  - 10/7/2020
DB  - Scopus
DO  - 10.1111/btp.12851
DP  - Scopus
IS  - 5
J2  - Biotropica
KW  - active restoration
deforestation
ecosystem services
natural regeneration
pandemic
passive restoration
regenerating forests
LA  - English
M3  - Note
N1  - Export Date: 7 October 2020
CODEN: BTROA
Correspondence Address: Zahawi, R.A.; Lyon Arboretum, University of Hawai'i at MānoaUnited States; email: rakan.zahawi@gmail.com
Funding text 1: We would like to thank Robin Chazdon, Pedro Brancalion, and one anonymous reviewer for great comments and suggestions that improved earlier drafts of this manuscript.
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PY  - 2020
SN  - 00063606 (ISSN)
SP  - 803-807
ST  - Potential impacts of COVID-19 on tropical forest recovery
T2  - Biotropica
TI  - Potential impacts of COVID-19 on tropical forest recovery
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091716652&doi=10.1111%2fbtp.12851&partnerID=40&md5=f647451aaa7009bd4cf2c597b38a2fff
VL  - 52
ID  - 7788956
ER  - 

TY  - JOUR
AB  - PURPOSE: To report a unique case of intraocular inflammation and outer retinal changes in a patient with coronavirus disease (COVID-19). CASE REPORT: A 57-year-old woman was seen 12 days after COVID-19 symptoms onset confirmed by positive IgM and IgG serological tests. No anterior chamber cells were seen. Color fundus photograph showed a yellowish lesion within the macular area, and fluorescein angiography revealed hyperfluorescence on the topography of the macular lesion in both eyes. Spectral-domain optical coherence tomography demonstrated hyperreflective pinpoints at the level of posterior vitreous hyaloid, corresponding to vitritis, hyperreflective lesions at the level of inner plexiform and ganglion cell layers, and disruption of the ellipsoid zone. CONCLUSION AND IMPORTANCE: COVID-19 is known to affect the inner retinal layers. The current case not only supports but also adds a vitreal and an outer retinal layer involvement that might also be caused by this infectious disease.
AD  - Department of Ophthalmology and Otorhinolaryngology, Federal University of Paran֙ , Curitiba, Brazil.
Retina Service, Oftalmolages Day Hospital , Lages, Brazil.
Department of Ophthalmology, Federal University of São Paulo/Paulista School of Medicine , São Paulo, Brazil.
Retina Service, Hospital de Olhos de Sergipe , Aracaju, Brazil.
Facultad de Ciencias, Pontificia Universidad Cat�Qlica de Valpara�Tso , Valpara�Tso, Chile.
AN  - 33021846
AU  - Zago Filho, L. A.
AU  - Lima, L. H.
AU  - Melo, G. B.
AU  - Zett, C.
AU  - Farah, M. E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/09273948.2020.1821898
DP  - NLM
ET  - 2020/10/07
J2  - Ocular immunology and inflammation
KW  - Covid-19
Coronavirus
outer retina
vitritis
LA  - eng
N1  - 1744-5078
Zago Filho, Luiz A
Lima, Luiz H
Melo, Gustavo B
Orcid: 0000-0001-5765-2008
Zett, Claudio
Farah, Michel E
Journal Article
England
Ocul Immunol Inflamm. 2020 Oct 6:1-3. doi: 10.1080/09273948.2020.1821898.
PY  - 2020
SN  - 0927-3948
SP  - 1-3
ST  - Vitritis and Outer Retinal Abnormalities in a Patient with COVID-19
T2  - Ocular immunology and inflammation
TI  - Vitritis and Outer Retinal Abnormalities in a Patient with COVID-19
ID  - 7791002
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 has affected people from all age groups, races and ethnicities. Given that many infected individuals are asymptomatic, they transmit the disease to others unknowingly, which has resulted in the spread of infection at an alarming rate. This review aims to provide an overview of the pathophysiology, preventive measures to reduce the disease spread, therapies currently in use, an update on vaccine development and opportunities for vaccine delivery. The World Health Organization has advised several precautions including social distancing, hand washing and the use of PPE including gloves and face masks for minimizing the spread of SARS-CoV-2 infection. At present, several antiviral therapies previously approved for other infections are being repositioned to study their efficacy against SARS-CoV-2. In addition, some medicines (i.e., remdesivir, chloroquine, hydroxychloroquine) have received emergency use authorisation from the FDA. Plasma therapy has also been authorised for emergency use for the treatment of COVID-19 on a smaller scale. However, no vaccine has been approved so far against this virus. Nevertheless, several potential vaccine targets have been reported, and development of different types of vaccines including DNA, mRNA, viral vector, inactivated, subunit and vaccine-like particles is in process. It is concluded that a suitable candidate delivered through an advanced drug delivery approach would effectively boost the immune system against this coronavirus.
AD  - Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.
Leicester School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK.
Nanotechnology and Integrated Bioengineering Centre, University of Ulster, Northern Ireland BT37 0QB, UK.
AN  - 33023033
AU  - Zafar, S.
AU  - Arshad, M. S.
AU  - Fatima, S.
AU  - Ali, A.
AU  - Zaman, A.
AU  - Sayed, E.
AU  - Chang, M. W.
AU  - Ahmad, Z.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/pharmaceutics12100945
DP  - NLM
ET  - 2020/10/08
IS  - 10
J2  - Pharmaceutics
KW  - Covid-19
SARS-CoV-2
coronavirus
drug delivery
immune response
immunization
infection
vaccine
LA  - eng
N1  - Zafar, Saman
Arshad, Muhammad Sohail
Fatima, Sameen
Ali, Amna
Zaman, Aliyah
Sayed, Elshaimaa
Chang, Ming-Wei
Ahmad, Zeeshan
Journal Article
Review
Switzerland
Pharmaceutics. 2020 Oct 3;12(10):E945. doi: 10.3390/pharmaceutics12100945.
PY  - 2020
SN  - 1999-4923 (Print)
1999-4923
ST  - COVID-19: Current Developments and Further Opportunities in Drug Delivery and Therapeutics
T2  - Pharmaceutics
TI  - COVID-19: Current Developments and Further Opportunities in Drug Delivery and Therapeutics
VL  - 12
ID  - 7790930
ER  - 

TY  - JOUR
AB  - Background Extended evidence has established that healthcare workers face several mental health problems during a disease outbreak, which could have a long-term impact To address these issues, elaboration and implementation of psychological/psychiatric interventions or strategies is of utmost importance In this context, this systematic review aimed at identifying strategies to manage mental health issues in healthcare workers during infectious disease outbreaks Methods PubMed, Cochrane, Scopus and Web of Science were searched to retrieve pertinent articles published in English until May 2020 Articles reporting measures, interventions, strategies, or recommendations to manage mental health problems in healthcare workers during an infectious disease outbreak, of any study design were included The quality assessment was performed according to the study design of the included articles Results Our search strategy produced a total of 2358 articles After the screening process 33 articles met the inclusion criteria, addressing COVID-19 (40%), followed by SARS (21%) and Ebola Virus (15%) The findings emphasized that organisations should follow an evidence-based approach and establish comprehensive programs to assist hospital staff during disease outbreaks The preliminary results show that the creation of a psychological response team, training, e-learning, courses, psychosocial counselling, screening instruments and telemedicine activities could improve the capacity of response and coping, and reduce mental health issues in healthcare workers Conclusions To minimize the psychological impact of future infectious disease outbreaks, evidence-based intervention strategies should be implemented to retain mental health among healthcare workers Our results may provide the necessary insights that could be applied during the COVID-19 pandemic Key messages During infectious disease outbreaks healthcare workers are faced with mental health issues, that need to be addressed through tailored interventions offering coping strategies and increase resilience Mental health related interventions or strategies include the implementation of professional training, psychosocial counselling, courses, and the creation of a psychological response team
AU  - Zace, D.
AU  - Hoxhaj, I.
AU  - Orfino, A.
AU  - Viteritti, A. M.
AU  - Silvetti, L.
AU  - Di Pietro, M. L.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Mental health interventions in healthcare workers in infectious disease outbreak-A systematic review
T2  - European Journal of Public Health
TI  - Mental health interventions in healthcare workers in infectious disease outbreak-A systematic review
UR  - https://doi.org/10.1093/eurpub/ckaa165.569
ID  - 7792910
ER  - 

TY  - JOUR
AB  - Purpose The COVID-19 surge required the deployment of large numbers of non-intensive care providers to assist in the management of the critically ill Institutions took a variety of approaches to “uptraining�?such providers though studies describing methods and effectiveness are lacking Materials and methods One hundred and seventy-five providers underwent a 3 h simulation-based session focused on management of shock, mechanical ventilation, acute respiratory distress syndrome, and critical care ultrasound All participants were sent surveys to assess their comfort with various aspects of critical care following return to their usual work environments Results One hundred and eight providers of 175 (62%) completed the survey Overall, 104/108 responders (96%) felt training either significantly or somewhat improved their knowledge in the management of ICU patients Responders felt most comfortable in the management of hypoxemia in intubated patients and the management of ventilated patients with acute respiratory distress syndrome (93% strongly agree or agree, and 86% strongly agree or agree, respectively) Fewer responders felt more comfortable using focused echocardiography (70% strongly agree or agree) and lung ultrasonography in following progression of COVID-19 (76% strongly agree or agree) Conclusions Simulation-based training improved provider comfort in the management of critically ill patients with COVID-19
AU  - Yuriditsky, Eugene
AU  - Horowitz, James M.
AU  - Nair, Sunil
AU  - Kaufman, Brian S.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Simulation-based uptraining improves provider comfort in the management of critically ill patients with COVID-19
T2  - Journal of Critical Care
TI  - Simulation-based uptraining improves provider comfort in the management of critically ill patients with COVID-19
UR  - https://doi.org/10.1016/j.jcrc.2020.09.035
ID  - 7793136
ER  - 

TY  - JOUR
AB  - Coronavirus causes a disease with high infectivity and pathogenicity, especially SARS in 2003, MERS in 2012, and COVID-2019 currently The spike proteins of these coronaviruses are critical for host cell entry by receptors Thus, searching for broad-spectrum anti-coronavirus candidates, such as spike protein inhibitors, is vital and desirable due to the mutations in the spike protein In this study, a combination of computer-aided drug design and biological verification was used to discover active monomers from traditional Chinese medicine Surface plasmon resonance (SPR) assays and NanoBit assays were used to verify the predicated compounds with their binding activities to spike proteins and inhibitory activities on the SARS-CoV-2 RBD/ACE2 interaction, respectively Furthermore, an MTT assay was used to evaluate the cell toxicities of active compounds As a result, glycyrrhizic acid (ZZY-44) was found to be the most efficient and nontoxic broad-spectrum anti-coronavirus molecule in vitro, especially the significant effect on SARS-CoV-2, which provided a theoretical basis for the study of the pharmacodynamic material basis of traditional Chinese medicine against SARS-CoV-2 and offered a lead compound for further structural modification in order to obtain more effective candidate drugs against SARS-CoV-2
AU  - Yu, Shaopeng
AU  - Zhu, Yuying
AU  - Xu, Jiaruo
AU  - Yao, Guangtao
AU  - Zhang, Pei
AU  - Wang, Mengge
AU  - Zhao, Yongfang
AU  - Lin, Guoqiang
AU  - Chen, Hongzhuan
AU  - Chen, Lili
AU  - Zhang, Jiange
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Glycyrrhizic Acid Exerts Inhibitory Activity against the Spike Protein of SARS-CoV-2
T2  - Phytomedicine
TI  - Glycyrrhizic Acid Exerts Inhibitory Activity against the Spike Protein of SARS-CoV-2
UR  - https://doi.org/10.1016/j.phymed.2020.153364
ID  - 7793077
ER  - 

TY  - JOUR
AB  - BACKGROUND: The outbreak of coronavirus disease 2019 (COVID-19) happened in early December and it has affected China in more ways than one. The societal response to the pandemic restricted medical students to their homes. Although students cannot learn about COVID-19 through clinical practice, they can still pay attention to news of COVID-19 through various channels. Although, as suggested by previous studies, some medical students have already volunteered to serve during the COVID-19 pandemic, the overall willingness of Chinese medical students to volunteer for such has not been systematically examined. AIM: To study Chinese medical students' interest in the relevant knowledge on COVID-19 and what roles they want to play in the pandemic. METHODS: Medical students at Peking Union Medical College were surveyed via a web-based questionnaire to obtain data on the extent of interest in the relevant knowledge on COVID-19, attitude towards volunteerism in the pandemic, and career preference. Logistic regression modeling was used to investigate possible factors that could encourage volunteerism among this group in a pandemic. RESULTS: A total of 552 medical students responded. Most medical students showed a huge interest in COVID-19. The extent of students' interest in COVID-19 varied among different student-classes (P  0.05). Senior students had higher scores than the other two classes. The number of people who were 'glad to volunteer' in COVID-19 represented 85.6% of the respondents. What these students expressed willingness to undertake involved direct, indirect, and administrative job activities. Logistic regression analysis identified two factors that negatively influenced volunteering in the pandemic: Student-class and hazards of the voluntary job. Factors that positively influenced volunteering were time to watch COVID-19 news, predictable impact on China, and moral responsibility. CONCLUSION: More innovative methods can be explored to increase Chinese medical students' interest in reading about the relevant knowledge on COVID-19 and doing voluntary jobs during the pandemic.
AD  - Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Department of Pulmonary and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
Department of Plastic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. pumclongxiao@126.com.
AN  - 33024718
AU  - Yu, N. Z.
AU  - Li, Z. J.
AU  - Chong, Y. M.
AU  - Xu, Y.
AU  - Fan, J. P.
AU  - Yang, Y.
AU  - Teng, Y.
AU  - Zhang, Y. W.
AU  - Zhang, W. C.
AU  - Zhang, M. Z.
AU  - Huang, J. Z.
AU  - Wang, X. J.
AU  - Zhang, S. Y.
AU  - Long, X.
C1  - 10/7/2020
C2  - PMC7520873
DA  - Sep 25
DB  - PubMed
DO  - 10.5501/wjv.v9.i3.38
DP  - NLM
ET  - 2020/10/08
IS  - 3
J2  - World journal of virology
KW  - Covid-19
Chinese medical students
Medical education
Public health emergency of international concern
Volunteer
declare.
LA  - eng
N1  - Yu, Nan-Ze
Li, Zhi-Jin
Chong, Yu-Ming
Xu, Yuan
Fan, Jun-Ping
Yang, Yang
Teng, Yue
Zhang, Yu-Wei
Zhang, Wen-Chao
Zhang, Ming-Zi
Huang, Jiu-Zuo
Wang, Xiao-Jun
Zhang, Shu-Yang
Long, Xiao
Journal Article
United States
World J Virol. 2020 Sep 25;9(3):38-46. doi: 10.5501/wjv.v9.i3.38.
PY  - 2020
SN  - 2220-3249 (Print)
2220-3249
SP  - 38-46
ST  - Chinese medical students' interest in COVID-19 pandemic
T2  - World journal of virology
TI  - Chinese medical students' interest in COVID-19 pandemic
VL  - 9
ID  - 7790775
ER  - 

TY  - JOUR
AB  - Objectives The clinical performance of the BD Veritor�?System for Rapid Detection of SARS-CoV-2 nucleocapsid antigen (Veritor), a chromatographic immunoassay used for SARS-CoV-2 point-of-care testing, was evaluated using nasal specimens from individuals with COVID-19 symptoms.Methods: Two studies were completed to determine clinical performance. In the first study, nasal specimens and either nasopharyngeal or oropharyngeal specimens from 251 participants with COVID-19 symptoms (�? days from symptom onset [DSO]), �?8 years of age, were utilized to compare Veritor with the Lyra�] SARS-CoV-2 PCR Assay (Lyra). In the second study, nasal specimens from 361 participants with COVID-19 symptoms (�? DSO), �?8 years of age, were utilized to compare performance of Veritor to that of the Sofia�] 2 SARS Antigen FIA test (Sofia 2). Positive, negative, and overall percent agreement (PPA, NPA, and OPA, respectively) were the primary outcomes.Results: In study 1, PPA for Veritor, compared to Lyra, ranged from 81.8%-87.5% for 0-1 through 0-6 DSO ranges. In study 2, Veritor had a PPA, NPA, and OPA of 97.4%, 98.1%, and 98.1%, respectively, with Sofia 2. Discordant analysis showed one Lyra positive missed by Veritor and five Lyra positives missed by Sofia 2; one Veritor positive result was negative by Lyra.Conclusions: Veritor met FDA-EUA acceptance criteria for SARS-CoV-2 antigen testing (�?0% PPA point estimate) for the 0-5 and 0-6 DSO ranges. Veritor and Sofia 2 showed a high degree of agreement for SARS-CoV-2 detection. The Veritor test allows for more rapid COVID-19 testing utilizing easy-to-collect nasal swabs, but demonstrated less than 100% PPA compared to PCR..
AD  - Tricore Reference Laboratory, 1001 Woodward Place, N.E., Albuquerque, NM, USA Steve.Young@Tricore.org.
Louisiana State University Health Sciences Center, 533 Bolivar Street, Room 711, New Orleans, LA, USA.
Becton, Dickinson and Company, BD Life Sciences - Integrated Diagnostic Solutions, 7 Loveton Circle, Sparks, MD, USA.
Tricore Reference Laboratory, 1001 Woodward Place, N.E., Albuquerque, NM, USA.
Becton, Dickinson and Company, BD Life Sciences - Integrated Diagnostic Solutions, 10865 Road to the Cure, San Diego, CA, USA.
STAT Research, 600 Aviator Court, Suite 100B, Vandalia, Ohio, USA.
Comprehensive Clinical Research, LLC., 603 Village Blvd., Suite 301 West Palm Beach, FL, USA.
AN  - 33023911
AU  - Young, S.
AU  - Taylor, S. N.
AU  - Cammarata, C. L.
AU  - Varnado, K. G.
AU  - Roger-Dalbert, C.
AU  - Montano, A.
AU  - Griego-Fullbright, C.
AU  - Burgard, C.
AU  - Fernandez, C.
AU  - Eckert, K.
AU  - Andrews, J. C.
AU  - Ren, H.
AU  - Allen, J.
AU  - Ackerman, R.
AU  - Cooper, C. K.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1128/jcm.02338-20
DP  - NLM
ET  - 2020/10/08
J2  - Journal of clinical microbiology
LA  - eng
N1  - 1098-660x
Young, Stephen
Taylor, Stephanie N
Cammarata, Catherine L
Varnado, Katey G
Roger-Dalbert, Celine
Montano, Amanda
Griego-Fullbright, Christen
Burgard, Cameron
Fernandez, Catherine
Eckert, Karen
Andrews, Jeffrey C
Ren, Huimiao
Allen, Joseph
Ackerman, Ronald
Cooper, Charles K
Journal Article
United States
J Clin Microbiol. 2020 Oct 6:JCM.02338-20. doi: 10.1128/JCM.02338-20.
PY  - 2020
SN  - 0095-1137
ST  - Clinical evaluation of BD Veritor SARS-CoV-2 point-of-care test performance compared to PCR-based testing and versus the Sofia 2 SARS Antigen point-of-care test
T2  - Journal of clinical microbiology
TI  - Clinical evaluation of BD Veritor SARS-CoV-2 point-of-care test performance compared to PCR-based testing and versus the Sofia 2 SARS Antigen point-of-care test
ID  - 7790863
ER  - 

TY  - JOUR
AU  - Yomoda, Kenji
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Concerns and stress caused by the novel coronavirus disease (COVIDCOVID-19) outbreak outbreak
T2  - Taiikugaku kenkyu (Japan Journal of Physical Education, Health and Sport Sciences)
TI  - Concerns and stress caused by the novel coronavirus disease (COVIDCOVID-19) outbreak outbreak
UR  - https://doi.org/10.5432/jjpehss.20048
ID  - 7792743
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic by non-stop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report the discovery of suramin, a 100-year-old drug, as a potent inhibitor of the SARS-CoV-2 RNA dependent RNA polymerase (RdRp) through blocking the binding of RNA to the enzyme. In biochemical assays, suramin and its derivatives are at least 20-fold more potent than remdesivir, the currently approved nucleotide drug for COVID-19. The 2.6 Å cryo-EM structure of the viral RdRp bound to suramin reveals two binding sites of suramin, with one site directly blocking the binding of the RNA template strand and the other site clash with the RNA primer strand near the RdRp catalytic active site, therefore inhibiting the viral RNA replication. Furthermore, suramin potently inhibits SARS-CoV-2 duplication in Vero E6 cells. These results provide a structural mechanism for the first non-nucleotide inhibitor of the SARS-CoV-2 RdRp and a rationale for repurposing suramin for treating COVID-19.Competing Interest StatementThe authors have declared no competing interest.
AU  - Yin, Wanchao
AU  - Luan, Xiaodong
AU  - Li, Zhihai
AU  - Zhang, Leike
AU  - Zhou, Ziwei
AU  - Gao, Minqi
AU  - Wang, Xiaoxi
AU  - Zhou, Fulai
AU  - Shi, Jingjing
AU  - You, Erli
AU  - Liu, Mingliang
AU  - Wang, Qingxia
AU  - Wang, Qingxing
AU  - Jiang, Yi
AU  - Jiang, Hualiang
AU  - Xiao, Gengfu
AU  - Yu, Xuekui
AU  - Zhang, Shuyang
AU  - Xu, H. Eric
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.328336
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.328336
ST  - Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19 (preprint)
T2  - bioRxiv
TI  - Structural basis for repurposing a 100-years-old drug suramin for treating COVID-19 (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.328336.abstract
ID  - 7794718
ER  - 

TY  - JOUR
AU  - Yerasi, Charan
AU  - Khalid, Nauman
AU  - Khan, Jaffar M.
AU  - Hashim, Hayder
AU  - Waksman, Ron
AU  - Bernardo, Nelson
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - “STRIATE-G (Stent RetRIever and Aspiration ThrombEctomy from Guide catheter)�?Technique for COVID-19 STEMI
T2  - JACC: Cardiovascular Interventions
TI  - “STRIATE-G (Stent RetRIever and Aspiration ThrombEctomy from Guide catheter)�?Technique for COVID-19 STEMI
UR  - https://doi.org/10.1016/j.jcin.2020.09.045
ID  - 7793139
ER  - 

TY  - JOUR
AB  - Abstract Background: Limited evidence is available on the health effects of particulate matter (i.e. PM2.5, particulate matter with an aerodynamic diameter &amp;lt; 2.5μm; PM10, &amp;lt; 10μm; PM2.5-10, 2.5-10μm) during the pandemic of COVID-19 in Italy. Objectives: To examine the associations between all-cause mortality and daily PM2.5, PM2.5-10, and PM10 in the pandemic period, and compare them to the normal periods (2015-2019) in Italy. Methods: We collected daily data regarding all-cause (stratified by age and gender), and PM2.5, PM2.5-10, and PM10 for 107 Italian provinces from 1, January 2015 to 31, May 2020. A time-stratified case-cross design with the distributed lag non-linear model was used to examine the association between PM and all-cause mortality during the first three months of the COVID-19 outbreak (March to May in 2020) and the same months in 2015-2019. We also compared the counts and fractions of death attributable to PM in two periods. Results: Overall, Italy saw an increase in daily death counts while slight decreases in PM concentrations in 2020 pandemic period compared to same months of 2015-2019. Mortality effects were significant in lag 0-3 days for PM2.5, lag 0-2 for PM10, and lag 0-1 for PM2.5-10. Each 10 μg/m3 increase in PM was associated much higher increase in daily all-cause mortality during 2020 pandemic period compared to the same months during 2015-2019 [increased mortality rate: 7.24 % (95%CI: 4.84%, 9.70%) versus 1.69% (95%CI: 1.12%, 2.25%) for PM2.5; 3.45 % (95%C: 2.58%, 4.34%) versus 1.11% (95%CI: 0.79%, 1.42%) for PM10, 4.25% (95%CI: 2.99%, 5.52%) versus 1.76% (95%CI: 1.14%, 2.38%) for PM2.5-10]. The counts and fractions of deaths attributable to PM were higher in 2020 than the normal periods for PM2.5 (attributable death counts: 20,062 in 2020 versus 3,927 per year in 2015-2019; attributable fractions: 10.2% versus 2.4%), PM10 (15,112 versus 3,999; 7.7% versus 2.5%), and PM2.5-10 (7,193 versus 2303; 3.7% versus 1.4%). Conclusions: COVID-19 pandemic increased the vulnerability and excess cases of all-cause mortality associated with short-term exposure to PM2.5, PM2.5-10 and PM10 in Italy, despite a decline in air pollution level. This suggests using historical PM-mortality association to calculate health benefits associated with reduction in PMs has big uncertainties.Competing Interest StatementThe authors have declared no competing interest.Funding StatementFunding: No specific funding for this study. TY, and RX were supported by China Scholarship Council funds (number 201906320051 for TY and 201806010405 for RX); SL by an Early Career Fellowship of the Australian National Health and Medical Research Council (number APP1109193); and YG by Career Development Fellowships of the Australian National Health and Medical Research Council (numbers APP1107107 and APP1163693)Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Monash University approved.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesOriginal data are open sources.
AU  - Ye, Tingting
AU  - Xu, Rongbin
AU  - Yu, Wenhua
AU  - Chen, Zhaoyue
AU  - Guo, Yuming
AU  - Li, Shanshan
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20206052
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20206052
ST  - Vulnerability and burden of all-cause mortality associated with particulate air pollution increased during COVID-19 pandemic: a nationwide observed study in Italy (preprint)
T2  - medRxiv
TI  - Vulnerability and burden of all-cause mortality associated with particulate air pollution increased during COVID-19 pandemic: a nationwide observed study in Italy (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.02.20206052.abstract
ID  - 7794736
ER  - 

TY  - JOUR
AB  - Intensive worldwide efforts are underway to determine both the pathogenesis of SARS-CoV-2 infection and the immune responses in COVID-19 patients in order to develop effective therapeutics and vaccines. One type of cell that may contribute to these immune responses is the ��δ T lymphocyte, which plays a key role in immunosurveillance of the mucosal and epithelial barriers by rapidly responding to pathogens. Although found in low numbers in blood, ��δ T cells consist the majority of tissue-resident T cells and participate in the front line of the host immune defense. Previous studies have demonstrated the critical protective role of ��δ T cells in immune responses to other respiratory viruses, including SARS-CoV-1. However, no studies have profoundly investigated these cells in COVID-19 patients to date. ��δ T cells can be safely expanded in vivo using existing inexpensive FDA-approved drugs such as bisphosphonate, in order to test its protective immune response to SARS-CoV-2. To support this line of research, we review insights gained from previous coronavirus research, along with recent findings, discussing the potential role of ��δ T cells in controlling SARS-CoV-2. We conclude by proposing several strategies to enhance ��δ T cell's antiviral function, which may be used in developing therapies for COVID-19.
AD  - Stem Cell Transplantation and Regenerative Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
Australian Institute of Tropical Health and Medicine, CPHMVS, James Cook University, Townsville, QLD, Australia.
AN  - 33023358
AU  - Yazdanifar, M.
AU  - Mashkour, N.
AU  - Bertaina, A.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1080/1040841x.2020.1822279
DP  - NLM
ET  - 2020/10/08
J2  - Critical reviews in microbiology
KW  - Covid-19
SARS-CoV-2
coronavirus
immune response
��δ T cell
LA  - eng
N1  - 1549-7828
Yazdanifar, Mahboubeh
Orcid: 0000-0003-1884-3383
Mashkour, Narges
Bertaina, Alice
Journal Article
England
Crit Rev Microbiol. 2020 Oct 7:1-14. doi: 10.1080/1040841X.2020.1822279.
PY  - 2020
SN  - 1040-841x
SP  - 1-14
ST  - Making a case for using ��δ T cells against SARS-CoV-2
T2  - Critical reviews in microbiology
TI  - Making a case for using ��δ T cells against SARS-CoV-2
ID  - 7790914
ER  - 

TY  - JOUR
AB  - STATEMENT OF PROBLEM: Synchronous online prosthodontic courses became a popular learning mode during the 2020 COVID-19 pandemic crisis. Nonetheless, the extent of learner participation and completion of these courses remains unknown. PURPOSE: The purpose of this study was to assess learner behaviors in synchronous online prosthodontic continuing education lectures in China during the 2020 COVID-19 pandemic. MATERIAL AND METHODS: All live online prosthodontic courses held by an online dental school in China from February to May 2020 were retrieved. The no-cost lectures could be accessed anonymously and viewed repeatedly on the day of broadcast. Learning behavior data (teacher speaking time, audience total, timing of first visit to the online classroom, viewing time, and completion rate) were obtained. Learning progress was calculated by dividing viewing time by teacher speaking time. When a learner progressed through 95% of a lecture, the lecture was considered completed. RESULTS: A total of 41�?81 learners participated in 18 online prosthodontic courses, which had a mean duration of 77.2 �u15.8 minutes. For each lecture, 2321 �u1454 participants attended, with 510 �u404 participants completing each session. There were 13�?98 participants (31.35%) who viewed the lectures for less than 1 minute. Approximately half of the participants viewed the lectures for less than 10 minutes, with their learning progress failing to pass 10%. The average completion rate was 21.97%, with variation in completion rate dependent on when a learner first visited the online classroom. Significant differences were found among the lecture completion rates and the timing of the first visit to the online classroom (P.001). CONCLUSIONS: Synchronous online prosthodontic education courses in China had a high number of participants but low learning progress and completion rates during the 2020 COVID-19 pandemic.
AD  - Associate Professor, Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, PR China.
Lecturer, The Second Clinical Division, Peking University School and Hospital of Stomatology, Beijing, PR China.
Associate Professor, Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, PR China. Electronic address: liuxiaoqiang@bjmu.edu.cn.
Professor, Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing, PR China.
AN  - 33023743
AU  - Yang, X.
AU  - Li, D.
AU  - Liu, X.
AU  - Tan, J.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.prosdent.2020.08.004
DP  - NLM
ET  - 2020/10/08
J2  - The Journal of prosthetic dentistry
LA  - eng
N1  - 1097-6841
Yang, Xu
Li, Deli
Liu, Xiaoqiang
Tan, Jianguo
Journal Article
United States
J Prosthet Dent. 2020 Oct 3:S0022-3913(20)30431-5. doi: 10.1016/j.prosdent.2020.08.004.
PY  - 2020
SN  - 0022-3913
ST  - Learner behaviors in synchronous online prosthodontic education during the 2020 COVID-19 pandemic
T2  - Journal of prosthetic dentistry
TI  - Learner behaviors in synchronous online prosthodontic education during the 2020 COVID-19 pandemic
ID  - 7790881
ER  - 

TY  - JOUR
AB  - The SARS-CoV-2 virus first broke out in China in early 2020. The early symptoms of COVID-19 are similar to those of influenza. Therefore, during the epidemic, patients with similar symptoms will be tested for multiple pathogens at the same time. In order to control the spread of SARS-CoV-2, China has taken many measures. Under this special situation, have the types and epidemic characteristics of respiratory viruses changed? The nucleic acid test results of influenza A virus, influenza B virus and respiratory syncytial virus, as well as the antibody test results of 8 common respiratory viruses of Jinan Central Hospital were collected before and after the occurrence of SARS-CoV-2, and age distribution and time distribution characteristics were statisticed. Furthermore the epidemiological characteristics of this new virus before and after the SARS-CoV-2 epidemic was compared. In the early stage of the SARS-CoV-2 epidemic, influenza A, influenza B and respiratory syncytial virus nucleic acid test samples were large, and the positive rate of the three viruses was high. After that, the sample size and positive rate decreased significantly. No co-infection of SARS-CoV-2 and other viruses was found in our hospital. The sample size before the SARS-CoV-2 outbreak was larger than that after the outbreak, but the positive rate of the outbreak was lower than that after the outbreak. And the infection rate of children decreased in the middle and late stages of the epidemic. This is because since January 23, in order to prevent the spread of the new crown epidemic, my country has adopted measures such as wearing masks, not gathering together, and quarantining at home. This not only prevents the spread of the new crown virus, but also prevents the common respiratory tract. The spread of the virus has reduced the incidence of residents.Competing Interest StatementThe authors have declared no competing interest.Funding StatementnoAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Jinan central hospitalAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data referred to in the manuscript and note links below is availability.
AU  - Yang, Weihua
AU  - Chen, Jian
AU  - Xu, Mingjie
AU  - Wang, Jun
AU  - Li, Huanjie
AU  - Wang, Yunshan
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.06.20207589
DP  - medRxiv
PY  - 2020
SP  - 2020.10.06.20207589
ST  - Epidemic characteristics of respiratory viruses in hospitals in a Chinese city during the SARS-CoV-2 epidemic (preprint)
T2  - medRxiv
TI  - Epidemic characteristics of respiratory viruses in hospitals in a Chinese city during the SARS-CoV-2 epidemic (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.06.20207589.abstract
ID  - 7794725
ER  - 

TY  - JOUR
AU  - Yang, Stephen C.
AU  - Wang, Tim T.
AU  - Giannakopoulos, Helen E.
AU  - Saghezchi, Sohail
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The virtual residency fair: A legacy of the COVID-19 era and an opportunity for the future
T2  - Journal of Oral and Maxillofacial Surgery
TI  - The virtual residency fair: A legacy of the COVID-19 era and an opportunity for the future
UR  - https://doi.org/10.1016/j.joms.2020.09.037
ID  - 7793121
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative viral pathogen of coronavirus disease 2019 (COVID-19), appears to have various clinical presentations and may result in severe respiratory failure The global SARS-CoV-2-associated viral pneumonia pandemic was first reported in December 2019 in China Based on known pharmacological mechanisms, many therapeutic drugs have been repurposed to target SARS-CoV-2 Among these drugs, remdesivir appears to be the currently most promising according to several clinical trials and reports of compassionate use In this mini-review, we summarize the current evidence on the efficacy and challenges of remdesivir for the treatment of coronavirus disease 2019 (COVID-19)
AU  - Yang, Chih-Jen
AU  - Wei, Yu-Jui
AU  - Chang, Hus-Liang
AU  - Chang, Pi-Yu
AU  - Tsai, Chung-Chen
AU  - Chen, Yen-Hsu
AU  - Hsueh, Po-Ren
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Remdesivir Use in the Coronavirus Disease 2019 Pandemic: A Mini-Review
T2  - Journal of Microbiology, Immunology and Infection
TI  - Remdesivir Use in the Coronavirus Disease 2019 Pandemic: A Mini-Review
UR  - https://doi.org/10.1016/j.jmii.2020.09.002
ID  - 7793126
ER  - 

TY  - JOUR
AD  - Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China.
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China.
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan-Jinbo Joint Research Center, Fudan University, Shanghai, China.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. xuwei3322@smu.edu.cn.
State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, China. xiaogf@wh.iov.cn.
Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China. liusw@smu.edu.cn.
State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Southern Medical University, Guangzhou, China. liusw@smu.edu.cn.
AN  - 33024075
AU  - Yang, C.
AU  - Pan, X.
AU  - Xu, X.
AU  - Cheng, C.
AU  - Huang, Y.
AU  - Li, L.
AU  - Jiang, S.
AU  - Xu, W.
AU  - Xiao, G.
AU  - Liu, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41392-020-00325-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
Yang, Chan
Pan, Xiaoyan
Xu, Xinfeng
Cheng, Chen
Huang, Yuan
Li, Lin
Jiang, Shibo
Orcid: 0000-0001-8283-7135
Xu, Wei
Xiao, Gengfu
Liu, Shuwen
Orcid: 0000-0001-6346-5006
Letter
England
Signal Transduct Target Ther. 2020 Oct 6;5(1):220. doi: 10.1038/s41392-020-00325-1.
PY  - 2020
SN  - 2059-3635
SP  - 220
ST  - Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein
T2  - Signal transduction and targeted therapy
TI  - Salvianolic acid C potently inhibits SARS-CoV-2 infection by blocking the formation of six-helix bundle core of spike protein
VL  - 5
ID  - 7790846
ER  - 

TY  - JOUR
AB  - The 2020 Tokyo Olympics have been postponed due to the novel coronavirus (COVID-19) pandemic The implications for industries related to the Olympics&amp;mdash;tourism, hotels and restaurants, and others&amp;mdash;are expected to be affected by reduced demand Japanese workers in these industries were prepared to offer their hospitality to visitors from around the world They would be benefited not only by an increase in income but also in offering visitors a taste of Tokyo&amp;rsquo;s great hospitality if the Olympics had been held in 2020 However, postponement of the sporting event is likely to have a significant impact on their happiness level We independently collected individual-level panel data from March to April 2020 In the survey, the respondents were asked about their happiness levels by choosing from 11 categories: 1 (very unhappy) and 11 (very happy) They were also asked about expected income changes from 2020 to 2021 Based on this, we examined the effect of postponement on happiness level and expected income change The sample was divided into sub-samples of areas including and excluding Tokyo We found that the happiness level of workers in the tourism and restaurant sectors declined drastically after the announcement of the postponement Only two weeks later, their happiness level did not alter from the pre-announcement level This tendency was strongly observed in Tokyo and the surrounding prefectures, but not in other prefectures However, workers engaged in the tourism and restaurant sectors did not predict a decrease in their income even after the postponement Combined, these findings indicate that loss of extending hospitality, rather than reduction in income, temporarily reduces the happiness level of workers
AU  - Yamamura, Eiji
AU  - Tsutsui, Yoshiro
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Impact of Postponing 2020 Tokyo Olympics on the Happiness of O-MO-TE-NA-SHI Workers in Tourism: A Consequence of COVID-19
T2  - Sustainability
TI  - The Impact of Postponing 2020 Tokyo Olympics on the Happiness of O-MO-TE-NA-SHI Workers in Tourism: A Consequence of COVID-19
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813282
ID  - 7793326
ER  - 

TY  - JOUR
AU  - Yamamoto, Shinya
AU  - Saito, Makoto
AU  - Nagai, Etsuko
AU  - Toriuchi, Keiko
AU  - Nagai, Hiroyuki
AU  - Yotsuyanagi, Hiroshi
AU  - Nakagama, Yu
AU  - Kido, Yasutoshi
AU  - Adachi, Eisuke
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Antibody Response to SARS-CoV-2 in people living with HIV
T2  - Journal of Microbiology, Immunology and Infection
TI  - Antibody Response to SARS-CoV-2 in people living with HIV
UR  - https://doi.org/10.1016/j.jmii.2020.09.005
ID  - 7793124
ER  - 

TY  - JOUR
AB  - Background Patients with severe coronavirus disease 2019 (COVID-19) develop acute respiratory distress and multi-system organ failure and are associated with poor prognosis and high mortality Thus, there is an urgent need to identify early diagnostic and prognostic biomarkers to determine the risk of developing serious illness Methods We retrospectively analyzed 114 patients with COVID-19 at the Jinyintan Hospital, Wuhan based on their clinical and laboratory data Patients were categorized into severe and mild to moderate disease groups We analyzed the potential of serological inflammation indicators in predicting the severity of COVID-19 in patients using univariate and multivariate logistic regression, receiver operating characteristic curves, and nomogram analysis The Spearman method was used to understand the correlation between the serological biomarkers and duration of hospital stay Results Patients with severe disease had reduced neutrophils and lymphocytes;severe coagulation dysfunction;altered content of biochemical factors (such as urea, lactate dehydrogenase);elevated high sensitivity C-reactive protein levels, neutrophil-lymphocyte, platelet-lymphocyte, and derived neutrophil-lymphocyte ratios, high sensitivity C-reactive protein-prealbumin ratio (HsCPAR), systemic immune-inflammation index, and high sensitivity C-reactive protein-albumin ratio (HsCAR);and low lymphocyte-monocyte ratio, prognostic nutritional index (PNI), and albumin-to-fibrinogen ratio PNI, HsCAR, and HsCPAR correlated with the risk of severe disease The nomogram combining the three parameters showed good discrimination with a C-index of 0 873 and reliable calibration Moreover, HsCAR and HsCPAR correlated with duration of hospital stay Conclusion Taken together, PNI, HsCAR, and HsCPAR may serve as accurate biomarkers for the prediction of disease severity in patients with COVID-19 upon admission/hospitalization
AU  - Xue, Guohui
AU  - Gan, Xing
AU  - Wu, Zhiqiang
AU  - Xie, Dan
AU  - Xiong, Yan
AU  - Hua, Lin
AU  - Zhou, Bing
AU  - Zhou, Nanjin
AU  - Xiang, Jie
AU  - Li, Junming
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Novel Serological Biomarkers for Inflammation in Predicting Disease Severity in Patients with COVID-19
T2  - International Immunopharmacology
TI  - Novel Serological Biomarkers for Inflammation in Predicting Disease Severity in Patients with COVID-19
UR  - https://doi.org/10.1016/j.intimp.2020.107065
ID  - 7793151
ER  - 

TY  - JOUR
AB  - (1) Background: Along with an increasing risk caused by migrant workers returning to the urban areas for the resumption of work and production and growing epidemiological evidence of possible transmission during the incubation period, a study of Coronavirus Disease 2019 (COVID-19) is warranted among key populations to determine the serum antibody against the SARS-CoV-2 and the carrying status of SARS-CoV-2 to identify potential asymptomatic infection and to explore the risk factors (2) Method: This is a cross-sectional seroepidemiologic study Three categories of targeted populations (close contacts, migrant workers who return to urban areas for work, and school children) will be included in this study as they are important for case identification in communities A multi-stage sampling method will be employed to acquire an adequate sample size Assessments that include questionnaires and blood, nasopharyngeal specimens, and feces collection will be performed via home-visit survey (3) Ethics and Dissemination: The study was approved by the Institute Review Board of School of Public Health, Fudan University (IRB#2020-04-0818) Before data collection, written informed consent will be obtained from all participants The manuscripts from this work will be submitted for publication in quality peer-reviewed journals and presented at national or international conferences
AU  - Xu, Shuang-Fei
AU  - Lu, Yi-Han
AU  - Zhang, Tao
AU  - Xiong, Hai-Yan
AU  - Wang, Wei-Bing
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Cross-Sectional Seroepidemiologic Study of Coronavirus Disease 2019 (COVID-19) among Close Contacts, Children, and Migrant Workers in Shanghai
T2  - International Journal of Environmental Research and Public Health
TI  - Cross-Sectional Seroepidemiologic Study of Coronavirus Disease 2019 (COVID-19) among Close Contacts, Children, and Migrant Workers in Shanghai
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813281
ID  - 7793327
ER  - 

TY  - JOUR
AD  - Department of Infectious Diseases, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
Department of Hematology, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China.
Guangdong Provincial Engineering Research Center of Molecular Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China; Department of Interventional Medicine, the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai, Guangdong Province, China. Electronic address: shanhong@mail.sysu.edu.cn.
AN  - 33022278
AU  - Xiao, F.
AU  - Tang, M.
AU  - Shan, H.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1053/j.gastro.2020.09.017
DP  - NLM
ET  - 2020/10/07
J2  - Gastroenterology
LA  - eng
N1  - 1528-0012
Xiao, Fei
Tang, Meiwen
Shan, Hong
Letter
United States
Gastroenterology. 2020 Oct 3:S0016-5085(20)35167-2. doi: 10.1053/j.gastro.2020.09.017.
PY  - 2020
SN  - 0016-5085
ST  - Reply to Letter to the Editor: Presence of SARS-Coronavirus-2 in the ileal mucosa: another evidence for infection of GI tract by this virus (GASTRO-D-20-01382)
T2  - Gastroenterology
TI  - Reply to Letter to the Editor: Presence of SARS-Coronavirus-2 in the ileal mucosa: another evidence for infection of GI tract by this virus (GASTRO-D-20-01382)
ID  - 7790971
ER  - 

TY  - JOUR
AB  - BACKGROUND: Smartphone enabled telehealth is important in response to strict hospital visitor restrictions during COVID-19 pandemic. The infection control measures became barriers for communication among patient, family, and multidisciplinary medical team about discharge planning and withdrawal of life sustaining treatments in palliative care. Also, the lack of nonverbal communication in telehealth may dampen the clinician-patient relationship during communication. OBJECTIVE: We aimed to establish the model of smartphone-enabled telehealth for palliative care family conference with integration of shared decision making concept (SDM) and VALUE (value, acknowledge, listen, understand, and elicit) approach in the face of COVID-19 threat. METHODS: The framework of the telehealth for palliative care family conference was developed on the basis of SDM model with "team talk", "option talk", and "decision talk". Three phases of the family conference including "pre-visit", "during-visit", and "post-visit" were also designed according to telehealth implementation guides. The model was implemented in a national cancer treatment center in Taiwan from February 2020. RESULTS: From February to April 2020 during COVID-19 era, 14 telehealth family conferences in the palliative care unit were analyzed. The patients age was 73 �u 10.1 (mean �u SD), and 6 patients (43%) were female. 12 patients were married (86%), and the main caregiver joining the conference were mostly spouse and children (71%). Most patients were terminally-ill cancer patients (13 out 14 patients, 93%), except 1 stroke patient. The percentage of reaching consensus on goal of care in "discharge planning" and "withdrawal of life sustaining treatments" during family conferences was 93%. There were 5 families feeling the family meeting to be good or very good (36%) and 9 were neutral (64%). CONCLUSIONS: The model of smartphone-enabled telehealth for palliative care family conference with integration of SDM demonstrated high satisfaction of the family and was effective in reaching consensus. The model might be applied to other countries to promote the quality of end of life care in the era of COVID-19 outbreak.
AD  - National Taiwan University Hospital, No.7, Chung Shan S. Rd.�Q�Zhongshan S. Rd.�Q? Zhongzheng Dist., Taipei City 100225, Taiwan (R.O.C.), Taipei City, TW.
AN  - 33021483
AU  - Wu, Y. R.
AU  - Chou, T. J.
AU  - Wang, Y. J.
AU  - Tsai, J. S.
AU  - Cheng, S. Y.
AU  - Yao, C. A.
AU  - Peng, J. K.
AU  - Hu, W. Y.
AU  - Chiu, T. Y.
AU  - Huang, H. L.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.2196/22069
DP  - NLM
ET  - 2020/10/07
J2  - JMIR mHealth and uHealth
LA  - eng
N1  - 2291-5222
Wu, Yu-Rui
Chou, Tzu-Jung
Wang, Yi-Jen
Tsai, Jaw-Shiun
Cheng, Shao-Yi
Yao, Chien-An
Peng, Jen-Kuei
Hu, Wen-Yu
Chiu, Tai-Yuan
Huang, Hsien-Liang
Journal Article
Canada
JMIR Mhealth Uhealth. 2020 Oct 5. doi: 10.2196/22069.
PY  - 2020
SN  - 2291-5222
ST  - Smartphone-enabled Telehealth for Palliative Care Family Conference during the COVID - 19 Pandemic: Pilot Observational Study
T2  - JMIR mHealth and uHealth
TI  - Smartphone-enabled Telehealth for Palliative Care Family Conference during the COVID - 19 Pandemic: Pilot Observational Study
ID  - 7791027
ER  - 

TY  - JOUR
AD  - MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, Guangdong, China.
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China.
Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, 250012, Jinan, Shandong, China.
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, 510182, Guangzhou, Guangdong, China. zhaojincun@gird.cn.
MOE Key Laboratory of Gene Function and Regulation, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, 510275, Guangzhou, Guangdong, China. cuij5@mail.sysu.edu.cn.
AN  - 33024073
AU  - Wu, Y.
AU  - Ma, L.
AU  - Zhuang, Z.
AU  - Cai, S.
AU  - Zhao, Z.
AU  - Zhou, L.
AU  - Zhang, J.
AU  - Wang, P. H.
AU  - Zhao, J.
AU  - Cui, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41392-020-00332-2
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
Wu, Yaoxing
Ma, Ling
Zhuang, Zhen
Cai, Sihui
Zhao, Zhiyao
Zhou, Lingli
Zhang, Jing
Wang, Pei-Hui
Zhao, Jincun
Orcid: 0000-0003-2515-5589
Cui, Jun
31870862/National Natural Science Foundation of China (National Science Foundation of China)/
Letter
England
Signal Transduct Target Ther. 2020 Oct 6;5(1):221. doi: 10.1038/s41392-020-00332-2.
PY  - 2020
SN  - 2059-3635
SP  - 221
ST  - Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling
T2  - Signal transduction and targeted therapy
TI  - Main protease of SARS-CoV-2 serves as a bifunctional molecule in restricting type I interferon antiviral signaling
VL  - 5
ID  - 7790847
ER  - 

TY  - JOUR
AB  - Pneumonia refers to a death-causing infection. Astragali Radix (AR) and Atractylodis Macrocephalae Rhizoma (AMR) are widely used as traditional tonic and promising edible immunomodulatory herbal medicine, but the systemic mechanism is not well understood. Therefore, a strategy based on network pharmacology and molecular docking was designed to explore the systemic mechanism of AR-AMR acting on pneumonia. After a series of bioinformatics assays, seven kernel targets were obtained, including TNF, IL6, IFNG, IL1B, IL10, IL4, and TLR9. And seven key compounds were identified as the synergy components of AR-AMR acting on pneumonia, the four key compounds belonging to AR were (3R)-3-(2-hydroxy-3,4-dimethoxyphenyl)-7-chromanol, formononetin, quercetin, and kaempferol, the three key compounds belonging to AMR were atractylone, 14-acetyl-12-senecioyl-2E, 8E, 10E-atractylentriol, and ��-Amyrin. The crucial pathways were mainly related to three modules, including immune diseases, infectious disease, and organismal systems. Collectively, these observations strongly suggest that the molecular mechanisms of AR-AMR regulating pneumonia were closely related to the correlation between inflammation and immune response. PRACTICAL APPLICATIONS: Astragali radix and Atractylodis macrocephalae rhizoma can be used as "medicine-food homology" for dietary supplement. AR and AMR are widely used as a traditional tonic and promising edible immunomodulatory herbal medicine. The AR-AMR herb pairs are used for compatibility many times in the recommended prescriptions in COVID-19 develop pneumonia in China. However, the ingredients and mechanisms of AR-AMR acting on Pneumonia via immunomodulation are unclear. In this paper, bioinformatics and network biology were used to systematically explore the mechanisms of the AR-AMR herb pairs in treatment of pneumonia, and further analyze the correlation mechanism between it and COVID-19 develop pneumonia. To sum up, our study reveals the interrelationships between components, targets, and corresponding biological processes of AR-AMR acting on pneumonia. Understanding these relationships may provide guidance and theoretical basis for the further application of AR-AMR herb pairs.
AD  - Department of Pharmacy, Anqing Medical College, Anqing, China.
Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
AN  - 33025599
AU  - Wu, Q.
AU  - Hu, Y.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/jfbc.13510
DP  - NLM
ET  - 2020/10/08
J2  - Journal of food biochemistry
KW  - Astragali radix
Atractylodis macrocephalae rhizome
immune
inflammation
molecular docking
network pharmacology
pneumonia
LA  - eng
N1  - 1745-4514
Wu, Qiguo
Orcid: 0000-0001-9414-3237
Hu, Yeqing
2019JXYJ005/Anqing Medical College/
Journal Article
United States
J Food Biochem. 2020 Oct 6:e13510. doi: 10.1111/jfbc.13510.
PY  - 2020
SN  - 0145-8884
SP  - e13510
ST  - Integrated network pharmacology and molecular docking strategy to explore the mechanism of medicinal and edible Astragali Radix-Atractylodis Macrocephalae Rhizoma acting on pneumonia via immunomodulation
T2  - Journal of food biochemistry
TI  - Integrated network pharmacology and molecular docking strategy to explore the mechanism of medicinal and edible Astragali Radix-Atractylodis Macrocephalae Rhizoma acting on pneumonia via immunomodulation
ID  - 7790692
ER  - 

TY  - JOUR
AB  - Summary COVID-19 has broken out since the end of December 2019 and is still spreading rapidly, which has been listed as an international concerning public health emergency We found the Spike protein of SARS-CoV-2 contains a furin cleavage site, which did not exist in any other betacoronavirus subtype B Based on a series of analysis, we speculate that the presence of a redundant furin cut site in its Spike protein is responsible for SARS-CoV-2’s stronger infectious than other coronaviruses, which leads to higher membrane fusion efficiency Subsequently, a library of 4,000 compounds including approved drugs and natural products were screened against furin through structure-based virtual screening and then assayed for their inhibitory effects on furin activity Among them, an anti-parasitic drug, Diminazene, showed the highest inhibition effects on furin with an IC50 of 5 42 �u 0 11 μM, which might be used for the treatment of COVID-19
AU  - Wu, Canrong
AU  - Zheng, Mengzhu
AU  - Yang, Yueying
AU  - Gu, Xiaoxia
AU  - Yang, Kaiyin
AU  - Li, Mingxue
AU  - Liu, Yang
AU  - Zhang, Qingzhe
AU  - Zhang, Peng
AU  - Wang, Yali
AU  - Wang, Qiqi
AU  - Xu, Yang
AU  - Zhou, Yirong
AU  - Zhang, Yonghui
AU  - Chen, Lixia
AU  - Li, Hua
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Furin, a potential therapeutic target for COVID-19
T2  - iScience
TI  - Furin, a potential therapeutic target for COVID-19
UR  - https://doi.org/10.1016/j.isci.2020.101642
ID  - 7793148
ER  - 

TY  - JOUR
AB  - The technique RT-qPCR for viral RNA detection is the current worldwide strategy used for early detection of the novel coronavirus SARS-CoV-2. RNA extraction is a key pre-analytical step in RT-qPCR, often achieved using commercial kits. However, the magnitude of the COVID-19 pandemic is causing disruptions to the global supply chains used by many diagnostic laboratories to procure the commercial kits required for RNA extraction. Shortage in these essential reagents is even more acute in developing countries with no means to produce kits locally. We sought to find an alternative procedure to replace commercial kits using common reagents found in molecular biology laboratories. Here we report a method for RNA extraction that takes about 40 min to complete ten samples, and is not more laborious than current commercial RNA extraction kits. We demonstrate that this method can be used to process nasopharyngeal swab samples and yields RT-qPCR results comparable to those obtained with commercial kits. Most importantly, this procedure can be easily implemented in any molecular diagnostic laboratory. Frequent testing is crucial for individual patient management as well as for public health decision making in this pandemic. Implementation of this method could maintain crucial testing going despite commercial kit shortages.
AD  - Department Clinical Laboratories, School of Medicine, Pontificia Universidad Cat�Qlica de Chile, Av. Vicuña Mackenna 4686, Santiago, Chile.
Department Molecular Genetics and Microbiology, School of Biological Sciences, Pontificia Universidad Cat�Qlica de Chile, Av. Libertador Bernardo O`Higgins 340, Santiago, Chile.
Laboratorio de Microbiolog�Ta. Servicio de Laboratorios Cl�Tnicos. Red de Salud UC-CHRISTUS, Santiago, Chile.
Departamento Enfermedades Infecciosas e Inmunolog�Ta Pedi֙trica, Escuela Medicina, Pontificia Universidad Cat�Qlica de Chile, Santiago, Chile.
Department Molecular Genetics and Microbiology, School of Biological Sciences, Pontificia Universidad Cat�Qlica de Chile, Av. Libertador Bernardo O`Higgins 340, Santiago, Chile. rgutierrez@bio.puc.cl.
Department Clinical Laboratories, School of Medicine, Pontificia Universidad Cat�Qlica de Chile, Av. Vicuña Mackenna 4686, Santiago, Chile. pgarciacan@uc.cl.
AN  - 33024174
AU  - Wozniak, A.
AU  - Cerda, A.
AU  - Ibarra-Henr�Tquez, C.
AU  - Sebastian, V.
AU  - Armijo, G.
AU  - Lamig, L.
AU  - Miranda, C.
AU  - Lagos, M.
AU  - Solari, S.
AU  - Guzm֙n, A. M.
AU  - Quiroga, T.
AU  - Hitschfeld, S.
AU  - Riveras, E.
AU  - Ferrés, M.
AU  - Gutiérrez, R. A.
AU  - Garc�Ta, P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73616-w
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Wozniak, Aniela
Cerda, Ariel
Ibarra-Henr�Tquez, Catalina
Sebastian, Valentina
Armijo, Grace
Lamig, Liliana
Miranda, Carolina
Lagos, Marcela
Solari, Sandra
Guzm֙n, Ana Mar�Ta
Quiroga, Teresa
Hitschfeld, Susan
Riveras, Eleodoro
Ferrés, Marcela
Gutiérrez, Rodrigo A
Garc�Ta, Patricia
15090007/Fondo de Desarrollo de Áreas Prioritarias (FONDAP) Center for Genome Regulation/
1180759/Fondo Nacional de Desarrollo Cient�Tfico y Tecnol�Qgico/
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16608. doi: 10.1038/s41598-020-73616-w.
PY  - 2020
SN  - 2045-2322
SP  - 16608
ST  - A simple RNA preparation method for SARS-CoV-2 detection by RT-qPCR
T2  - Scientific reports
TI  - A simple RNA preparation method for SARS-CoV-2 detection by RT-qPCR
VL  - 10
ID  - 7790835
ER  - 

TY  - JOUR
AB  - The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy against COVID-19.
AD  - The School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane 4072, Australia; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia. Electronic address: t.woodruff@uq.edu.au.
Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.
AN  - 33023856
AU  - Woodruff, T. M.
AU  - Shukla, A. K.
C1  - 10/7/2020
DA  - Sep 23
DB  - PubMed
DO  - 10.1016/j.it.2020.09.008
DP  - NLM
ET  - 2020/10/08
J2  - Trends in immunology
KW  - Covid-19
GPCRs
SARS-CoV-2
cellular signaling
complement system
drug discovery
LA  - eng
N1  - 1471-4981
Woodruff, Trent M
Shukla, Arun K
Journal Article
England
Trends Immunol. 2020 Sep 23:S1471-4906(20)30229-5. doi: 10.1016/j.it.2020.09.008.
PY  - 2020
SN  - 1471-4906
ST  - The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics
T2  - Trends in immunology
TI  - The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics
ID  - 7790872
ER  - 

TY  - JOUR
AB  - Exposure to air pollutants has been previously associated with respiratory viral infections, including influenza, measles, mumps, rhinovirus, and respiratory syncytial virus. Epidemiological studies have also suggested that air pollution exposure is associated with increased cases of SARS-CoV-2 infection and COVID-19-associated mortality, although the molecular mechanisms by which pollutant exposure affects viral infection and pathogenesis of COVID-19 remain unknown. In this review, we suggest potential molecular mechanisms that could account for this association. We have focused on the potential effect of exposure to nitrogen dioxide (NO(2) ), ozone (O(3) ), and particulate matter (PM) since there are studies investigating how exposure to these pollutants affects the life cycle of other viruses. We have concluded that pollutant exposure may affect different stages of the viral life cycle, including inhibition of mucociliary clearance, alteration of viral receptors and proteases required for entry, changes to antiviral interferon production and viral replication, changes in viral assembly mediated by autophagy, prevention of uptake by macrophages, and promotion of viral spread by increasing epithelial permeability. We believe that exposure to pollutants skews adaptive immune responses toward bacterial/allergic immune responses, as opposed to antiviral responses. Exposure to air pollutants could also predispose exposed populations toward developing COIVD-19-associated immunopathology, enhancing virus-induced tissue inflammation and damage.
AD  - Animal Science Department, Plants for Human Health Institute, N.C. Research Campus, North Carolina State University, Kannapolis, North Carolina.
Department of Microbiology and Immunology, Center for Molecular and Tumor Virology, Louisiana State University Health Sciences Center, Shreveport, Louisiana.
Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea.
AN  - 33022781
AU  - Woodby, B.
AU  - Arnold, M. M.
AU  - Valacchi, G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/nyas.14512
DP  - NLM
ET  - 2020/10/07
J2  - Annals of the New York Academy of Sciences
KW  - air pollution
coronavirus
nitrogen dioxide
ozone
particulate matter
viral infection
LA  - eng
N1  - 1749-6632
Woodby, Brittany
Arnold, Michelle M
Valacchi, Giuseppe
Journal Article
Review
United States
Ann N Y Acad Sci. 2020 Oct 6. doi: 10.1111/nyas.14512.
PY  - 2020
SN  - 0077-8923
ST  - SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?
T2  - Annals of New York Academy of Sciences
TI  - SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?
ID  - 7790944
ER  - 

TY  - JOUR
AU  - Wolinetz, Carrie D.
AU  - Collins, Francis S.
C1  - 10/7/2020
DA  - 2020/08
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - en
PY  - 2020
ST  - Recognition of Research Participants' Need for Autonomy: Remembering the Legacy of Henrietta Lacks
T2  - JAMA
TI  - Recognition of Research Participants' Need for Autonomy: Remembering the Legacy of Henrietta Lacks
UR  - https://dx.doi.org/10.1001/jama.2020.15936
ID  - 7793381
ER  - 

TY  - JOUR
AU  - Wolf, Jayanthi
AU  - Hansen, Ryan
AU  - Hassis, Kimberly
AU  - Lapps, William
AU  - Warmuth, Emese
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The impact of export regulations on recombinant viral vaccine development for emerging infectious diseases
T2  - Vaccine
TI  - The impact of export regulations on recombinant viral vaccine development for emerging infectious diseases
UR  - https://doi.org/10.1016/j.vaccine.2020.09.057
ID  - 7793043
ER  - 

TY  - JOUR
AB  - In this report, I review interdisciplinary research on the actual and potential consequences of FinTech, with emphasis on ideas from and for geographers, and three areas: financial sector and centres, financial regulation and stability, and financial inclusion and governance I show that the consequences of FinTech are full of controversies, which are part of broader, long-standing debates on the role of finance in economy and society, and need to be approached from geographical perspectives The intense fusion of fin and tech, arguably accelerated by the COVID-19 pandemic, complicates and elevates these controversies to a new level
AU  - W�Qjcik, Dariusz
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Financial geography II: The impacts of FinTech �?Financial sector and centres, regulation and stability, inclusion and governance
T2  - Progress in Human Geography
TI  - Financial geography II: The impacts of FinTech �?Financial sector and centres, regulation and stability, inclusion and governance
UR  - https://doi.org/10.1177/0309132520959825
ID  - 7792833
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic exposed long-standing class-based inequities in education and as a result highlighted the role of structural supports (e g , food, stable housing, income) promoting economic opportunity Although social class mobility is often attributed to perceptions of hard work, science does not support these dominant narratives Instead, access to quality education and structural supports correlate with economic uplift By eliminating structural barriers to low-income college students? degree completion and coordinating efforts to assist low-income students, policymakers can restore the promise of economic mobility through education This article focuses on the psychological and behavioral science that should inform higher education policy As the country recovers from the COVID-19 pandemic, a structure-based, scientific approach to facilitate equal opportunity in higher education is vital to spurring greater economic mobility and avoiding further entrenchment of economic inequalities
AU  - Williams, Wendy R.
AU  - Reppond, Harmony A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - More Than Just Hard Work: Educational Policies to Facilitate Economic Mobility
T2  - Policy Insights from Behavioral and Brain Sciences
TI  - More Than Just Hard Work: Educational Policies to Facilitate Economic Mobility
UR  - https://doi.org/10.1177/2372732220943912
ID  - 7792805
ER  - 

TY  - JOUR
AB  - Objective: As cases of COVID-19 infections surge, concerns have renewed about intensive care units (ICU) being overwhelmed and the need for specific triage protocols over winter. This study aimed to help inform triage guidance by exploring the view of lay people about factors to include in triage decisions. Design, setting and participants: Online survey between 29th May and 22nd June 2020 based on hypothetical triage dilemmas. Participants recruited from existing market research panels, representative of the UK general population. Scenarios were presented in which a single ventilator is available, and two patients require ICU admission and ventilation. Patients differed in one of: chance of survival, life expectancy, age, expected length of treatment, disability, and degree of frailty. Respondents were given the option of choosing one patient to treat, or tossing a coin to decide. Results: Seven hundred and sixty-three participated. A majority of respondents prioritized patients who would have a higher chance of survival (72-93%), longer life expectancy (78-83%), required shorter duration of treatment (88-94%), were younger (71-79%), or had a lesser degree of frailty (60- 69% all p&amp;lt; .001). Where there was a small difference between two patients, a larger proportion elected to toss a coin to decide which patient to treat. A majority (58-86%) were prepared to withdraw treatment from a patient in intensive care who had a lower chance of survival than another patient currently presenting with COVID-19. Respondents also indicated a willingness to give higher priority to healthcare workers and to patients with young children. Conclusion: Members of the UK general public potentially support a broadly utilitarian approach to ICU triage in the face of overwhelming need. Survey respondents endorsed the relevance of patient factors currently included in triage guidance, but also factors not currently included. They supported the permissibility of reallocating treatment in a pandemicCompeting Interest StatementThe authors have declared no competing interest.Funding StatementThis study was supported by a grant from the University of Oxford Medical Sciences Division COVID-19 Research Response Fund. DW and JS were supported for this work by a grant from the Wellcome trust 203132/Z/16/Z. JS was supported by Wellcome trust grant 104848/Z/14/Z and, through his involvement with the Murdoch Children&#039;s Research Institute, was supported by the Victorian Government&#039;s Operational Infrastructure Support Program. The funders had no role in the preparation of this manuscript or the decision to submit for publication.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The experiment was approved by the University of Oxford Central University Research Ethics Committee [R69537/RE001].All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data and materials for the survey are available through the Open Science Framework repository (https://osf.io/gta3k/)https://osf.io/gta3k/
AU  - Wilkinson, Dominic
AU  - Zohny, Hazem
AU  - Kappes, Andreas
AU  - Sinnott-Armstrong, Walter
AU  - Savulescu, Julian
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.06.20207662
DP  - medRxiv
PY  - 2020
SP  - 2020.10.06.20207662
ST  - Which factors should be included in triage? An online survey of the attitudes of the UK general public to pandemic triage dilemmas (preprint)
T2  - medRxiv
TI  - Which factors should be included in triage? An online survey of the attitudes of the UK general public to pandemic triage dilemmas (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.06.20207662.abstract
ID  - 7794730
ER  - 

TY  - JOUR
AB  - Increased expression of pulmonary ACE2, the SARS-CoV-2 receptor, could contribute to increased infectivity of COVID-19 in subjects with diabetes, but ACE2 expression has not been studied in lung tissue of subjects with diabetes. We therefore studied ACE2 mRNA and protein expression in lung tissue samples of patients with and without diabetes that were collected between 2002 and 2020 from patients undergoing lobectomy for lung tumors. For RT-PCR analyses, samples from 15 subjects with diabetes were compared to 91 randomly chosen control samples. For immunohistochemical staining, samples from 26 subjects with diabetes were compared to 66 randomly chosen control samples. mRNA expression of ACE2 was measured by quantitative RT-PCR. Protein levels of ACE2 were visualized by immunohistochemistry on paraffin-embedded lung tissue samples and quantified in alveolar and bronchial epithelium. Pulmonary ACE2 mRNA expression was not different between subjects with or without diabetes. In contrast, protein levels of ACE2 were significantly increased in both alveolar tissue and bronchial epithelium of patients with diabetes as compared with control subjects, independent of smoking, COPD, BMI, RAAS-inhibitor use and other potential confounders. To conclude, we show increased bronchial and alveolar ACE2 protein expression in patients with diabetes. Further research is needed to elucidate whether up-regulation of ACE2 expression in airways and lungs has consequences on infectivity and clinical outcomes of COVID-19.
AD  - Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. sara.wijnant@UGent.be.
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Department of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium.
Department of Respiratory Diseases, Erasmus Medical Center, Rotterdam, The Netherlands.
Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium.
Department of Endocrinology, Ghent University Hospital, Ghent, Belgium.
AN  - 33024003
AU  - Wijnant, S. R.
AU  - Jacobs, M.
AU  - Van Eeckhoutte, H. P.
AU  - Lapauw, B.
AU  - Joos, G. F.
AU  - Bracke, K. R.
AU  - Brusselle, G. G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.2337/db20-0669
DP  - NLM
ET  - 2020/10/08
J2  - Diabetes
LA  - eng
N1  - 1939-327x
Wijnant, Sara Ra
Jacobs, Merel
Van Eeckhoutte, Hannelore P
Lapauw, Bruno
Joos, Guy F
Bracke, Ken R
Brusselle, Guy G
Journal Article
United States
Diabetes. 2020 Oct 6:db200669. doi: 10.2337/db20-0669.
PY  - 2020
SN  - 0012-1797
ST  - Expression of ACE2, the SARS-CoV-2 Receptor, in Lung Tissue of Patients With Type 2 Diabetes
T2  - Diabetes
TI  - Expression of ACE2, the SARS-CoV-2 Receptor, in Lung Tissue of Patients With Type 2 Diabetes
ID  - 7790854
ER  - 

TY  - JOUR
AB  - Our aim was to analyze the prevalence of unhealthy movement behavior clusters before and during the COVID-19 pandemic, as well as to investigate whether changes in the number of unhealthy behaviors during the COVID-19 pandemic quarantine were associated with mental health indicators. Data of 38,353 Brazilian adults from a nationwide behavior research were used. For movement behaviors, participants reported the frequency and duration of physical activity and daily time on TV viewing and computer/tablet use before and during the pandemic period. Participants also reported the frequency of loneliness, sadness (feeling sad, crestfallen, or depressed), and anxiety feelings (feeling worried, anxious, or nervous) during the pandemic period. Sex, age group, highest academic achievement, working status during quarantine, country region, and time adhering to the quarantine were used as correlates. We used descriptive statistics and logistic regression models for the data analysis. The prevalence of all movement behavior clusters increased during the COVID-19 pandemic. The cluster of all three unhealthy movement behaviors increased from 4.6% (95% confidence interval [CI]: 3.9-5.4) to 26.2% (95% CI: 24.8-27.7). Younger adults, people with higher academic achievement, not working or working at home, and those with higher time in quarantine presented higher clustering. People that increased one and two or three unhealthy movement behaviors were, respectively, more likely to present loneliness (odds ratio [OR] = 1.41 [95% CI: 1.21-1.65] and OR = 1.71 [95% CI: 1.42-2.07]), sadness (OR = 1.25 [95% CI: 1.06-1.48] and OR = 1.73 [95% CI: 1.42-2.10]), and anxiety (OR = 1.34 [95% CI: 1.13-1.57] and OR = 1.78 [95% CI: 1.46-2.17]) during the COVID-19 quarantine. Clustering of unhealthy movement behaviors substantially increased and was associated with poorer mental health during the COVID-19 pandemic.
AD  - Department of Nutrition, School of Public Health, Universidade de São Paulo, Cerqueira César, São Paulo, Brazil.
Department of Physical Education, Federal University of Sergipe, São Crist�Qvão, Brazil.
Departamento de Enfermagem Materno-Infantil e Saúde Pública, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Instituto de Comunicação e Informação Cient�Tfica e Tecnol�Qgica em Saúde, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Department of Public Health, School of Medical Sciences, Universidade Estadual de Campinas, Campinas, Brazil.
AN  - 33021631
AU  - Werneck, A. O.
AU  - Silva, D. R.
AU  - Malta, D. C.
AU  - Souza-Júnior, P. R. B.
AU  - Azevedo, L. O.
AU  - Barros, M. B. A.
AU  - Szwarcwald, C. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/tbm/ibaa095
DP  - NLM
ET  - 2020/10/07
J2  - Translational behavioral medicine
KW  - Exercise
Sedentary behavior
Sedentary lifestyle
Sitting
LA  - eng
N1  - 1613-9860
Werneck, André O
Silva, Danilo R
Malta, Deborah C
Souza-Júnior, Paulo R B
Azevedo, Luiz O
Barros, Marilisa B A
Szwarcwald, Célia L
Journal Article
England
Transl Behav Med. 2020 Oct 6:ibaa095. doi: 10.1093/tbm/ibaa095.
PY  - 2020
SN  - 1613-9860
ST  - Changes in the clustering of unhealthy movement behaviors during the COVID-19 quarantine and the association with mental health indicators among Brazilian adults
T2  - Translational behavioral medicine
TI  - Changes in the clustering of unhealthy movement behaviors during the COVID-19 quarantine and the association with mental health indicators among Brazilian adults
ID  - 7791017
ER  - 

TY  - JOUR
AU  - Watts, Jameson
AU  - Adriano, Anastasia
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Uncovering the Sources of Machine-Learning Mistakes in Advertising: Contextual Bias in the Evaluation of Semantic Relatedness
T2  - Journal of Advertising
TI  - Uncovering the Sources of Machine-Learning Mistakes in Advertising: Contextual Bias in the Evaluation of Semantic Relatedness
UR  - https://doi.org/10.1080/00913367.2020.1821411
ID  - 7792986
ER  - 

TY  - JOUR
AB  - Significant restrictions on movement outside the home due to the global COVID-19 pandemic have intensified the importance of everyday digital technologies for communicating remotely with intimate others In this article, we draw on findings from a home-based video ethnography project in Sydney to identify the ways that digital devices and software served to support and enhance intimacy and sociality in this period of crisis and isolation Digital communication technologies had an increased presence in people?s domestic lives during lockdown For many people, video calling software had become especially important, allowing them to achieve greater closeness and connection with their friends and family in enacting both everyday routines and special events These findings surface the digital and non-digital materialities of sociality and intimacy, and the capacities opened by people?s improvisation with the affordances of home-based communication technologies at a time of extended physical isolation
AU  - Watson, Ash
AU  - Lupton, Deborah
AU  - Michael, Mike
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Enacting intimacy and sociality at a distance in the COVID-19 crisis: the sociomaterialities of home-based communication technologies
T2  - Media International Australia
TI  - Enacting intimacy and sociality at a distance in the COVID-19 crisis: the sociomaterialities of home-based communication technologies
UR  - https://doi.org/10.1177/1329878X20961568
ID  - 7792844
ER  - 

TY  - JOUR
AB  - In the field of transfusion medicine, many pathogen reduction techniques (PRTs) are currently available, including those based on photochemical (PI) and photodynamic inactivation (PDI). This is particularly important in the face of emerging viral pathogens that may pose a threat to blood recipients, as in the case of the COVID-19 pandemic. However, PRTs have some limitations, primarily related to their adverse effects on coagulation factors, which should be considered before their intended use. A comprehensive search of PubMed, Wiley Online Library and Science Direct databases was conducted to identify original papers. As a result, ten studies evaluating fresh plasma and frozen-thawed plasma treated with different PI/ PDI methods and evaluating concentrations of coagulation factors and natural anticoagulants both before and after photochemical treatment were included in the review. The use of PI and PDI is associated with a significant decrease in the activity of all analysed coagulation factors, while the recovery of natural anticoagulants remains at a satisfactory level, variable for individual inactivation methods. In addition, the published evidence reviewed above does not unequivocally favour the implementation of PI/PDI either before freezing or after thawing as plasma products obtained with these two approaches seem to satisfy the existing quality criteria. Based on current evidence, if implemented responsibly and in accordance with the current guidelines, both PI and PDI can ensure satisfactory plasma quality and improve its safety.
AD  - Regional Centre for Transfusion Medicine, Bialystok, Poland. Electronic address: twasiluk@rckik.bialystok.pl.
Regional Centre for Transfusion Medicine, Bialystok, Poland.
Department of Haematology, Medical University of Bialystok, Bialystok, Poland.
Regional Centre for Transfusion Medicine, Bialystok, Poland; Department of Haematology, Medical University of Bialystok, Bialystok, Poland.
AN  - 33023853
AU  - Wasiluk, T.
AU  - Rogowska, A.
AU  - Boczkowska-Radziwon, B.
AU  - Zebrowska, A.
AU  - Bolkun, L.
AU  - Piszcz, J.
AU  - Radziwon, P.
C1  - 10/7/2020
DA  - Sep 28
DB  - PubMed
DO  - 10.1016/j.transci.2020.102953
DP  - NLM
ET  - 2020/10/08
J2  - Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
KW  - Covid-19
Pathogen reduction
Plasma for transfusion
SARS-CoV-2
LA  - eng
N1  - Wasiluk, Tomasz
Rogowska, Anna
Boczkowska-Radziwon, Barbara
Zebrowska, Agnieszka
Bolkun, Lukasz
Piszcz, Jaroslaw
Radziwon, Piotr
Journal Article
England
Transfus Apher Sci. 2020 Sep 28:102953. doi: 10.1016/j.transci.2020.102953.
PY  - 2020
SN  - 1473-0502 (Print)
1473-0502
SP  - 102953
ST  - Maintaining plasma quality and safety in the state of ongoing epidemic - The role of pathogen reduction
T2  - Transfusion and apheresis science : official journal of World Apheresis Association : official journal of European Society for Haemapheresis
TI  - Maintaining plasma quality and safety in the state of ongoing epidemic - The role of pathogen reduction
ID  - 7790873
ER  - 

TY  - JOUR
AB  - Background The Covid-19 pandemic is likely to lead to a significant increase in mental health disorders amongst healthcare workers (HCW). Aims We evaluated the prevalence of anxiety, depressive and post-traumatic stress disorder (PTSD) symptoms in a HCW population in the United Kingdom (UK), to identify subgroups most at risk. Methods An electronic survey was conducted between the 05/06/2020 and 31/07/2020 of all hospital HCW in the West Midlands, UK using clinically validated questionnaires: Patient Health Questionnaire-4 (PHQ-4) and the Impact of Event Scale-Revised (IES-R). Univariate analyses and adjusted logistic regression analyses were performed to estimate the strengths in associations. Results There were 2638 eligible participants who completed the survey (female: 79.5%, median age: 42 [IQR: 32-51] years). The prevalence rates of clinically significant symptoms of anxiety, depression and PTSD were 34.3%, 31.2% and 24.5% respectively. In adjusted analysis a history of mental health conditions was associated with clinically significant symptoms of anxiety (odds ratio 2.3 [95% CI 1.9-2.7]; p&amp;lt;0.001), depression (2.5 [2.1-3.0]; p&amp;lt;0.001) and PTSD (2.1 [1.7-2.5]; p&amp;lt;0.001). The availability of adequate personal protective equipment (PPE), wellbeing support and lower exposure to moral dilemmas at work demonstrated significant negative associations with former symptoms (p�?.001). Conclusions We report a high prevalence of clinically significant symptoms of anxiety, depression and PTSD in hospital HCW following the initial Covid-19 pandemic peak in the UK. Those with a history of mental health conditions were most at risk. Adequate PPE availability, access to wellbeing support and reduced exposure to moral dilemmas may protect hospital HCW from mental health symptoms.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe University Hospitals Birmingham Charity covered the operational expenses incurred during this study (Remittance Reference No: C05976).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was approved by the UK Health Research Authority (HRA, Reference: 20/HRA/2865). Research Ethics Committee approval was not required for this study and this was confirmed by the HRA. Site specific approval was obtained for participant recruitment from each of the research and development departments of all participating hospital Trusts (University Hospitals Birmingham NHS Foundation Trust, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham Women&#039;s and Children&#039;s Hospital NHS Trust, Royal Wolverhampton Hospital NHS Trust, Walsall Healthcare NHS Trust, Dudley Group of Hospitals NHS Trust, University Hospital Coventry and Warwickshire NHS Trust, Coventry and Warwickshire Partnership NHS Trust, Black Country Mental Health Partnership Trust, Birmingham and Solihull Mental Health NHS Trust). Informed consent was obtained from all participants and recorded electronically at the start of the study.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll relevant data and results included in t is article have been published along with the article and its supplementary information files. Anonymised data can be obtained on reasonable request from the corresponding author at the end of the STAT-STRESS Covid-19 study.
AU  - Wanigasooriya, Kasun
AU  - Palimar, Priyanka
AU  - Naumann, David
AU  - Ismail, Khalida
AU  - Fellows, Jodie L.
AU  - Logan, Peter
AU  - Thompson, Christopher V.
AU  - Bermingham, Helen
AU  - Beggs, Andrew D.
AU  - Ismail, Tariq
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205674
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205674
ST  - Mental health symptoms in a cohort of hospital healthcare workers following the first peak of the Covid-19 pandemic in the United Kingdom (preprint)
T2  - medRxiv
TI  - Mental health symptoms in a cohort of hospital healthcare workers following the first peak of the Covid-19 pandemic in the United Kingdom (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.02.20205674.abstract
ID  - 7794710
ER  - 

TY  - JOUR
AB  - Repurposing of approved antiviral drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a promising strategy to treat Coronavirus disease 2019 (COVID-19) patients. Previously we reported our hypothesis that the antiviral drugs with high lung distributions might benefit COVID-19 patients by reducing viral loads. So far, chloroquine, lopinavir, hydroxychloroquine, azithromycin, favipiravir, ribavirin, darunavir, remdesivir, and umifenovir have been tested in COVID-19 clinical trials. Here we validated our hypothesis by comparing the pharmacokinetics profiles of these drugs and their capabilities of reducing viral load in clinical trials. According to bulk RNA and single cell RNA sequencing analysis, we found that high expression of both angiotensin converting enzyme 2 (ACE2) and transmembrane Serine Protease 2 (TMPRSS2) makes the lung and intestine vulnerable to SARS-CoV-2. Hydroxychloroquine, chloroquine, and favipiravir, which were highly distributed to the lung, were reported to reduce viral loads in respiratory tract of COVID-19 patients. Conversely, drugs with poor lung distributions, including lopinavir/ritonavir, umifenovir and remdesivir, were insufficient to inhibit viral replication. Lopinavir/ritonavir might inhibit SARS-CoV-2 in the GI tract according to their distribution profiles. We concluded here that the antiviral drugs should be distributed straight to the lung tissue for reducing viral loads in respiratory tract of COVID-19 patients. Additionally, to better evaluate antiviral effects of drugs that target the intestine, the stool samples should also be collected for viral RNA test in the future.
AN  - PMC7536545
AU  - Wang, Yan
AU  - Chen, Lei
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.ejphar.2020.173634
DP  - NLM
J2  - Eur J Pharmacol
KW  - Coronavirus disease 2019
Tissue distribution
Antiviral drugs
Hydroxychloroquine
Chloroquine
Favipiravir
LA  - eng
N1  - PMC7536545[pmcid]
S0014-2999(20)30726-3[PII]
PY  - 2020
SN  - 0014-2999
1879-0712
SP  - 173634
ST  - Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment
T2  - European Journal of Pharmacology
TI  - Tissue distributions of antiviral drugs affect their capabilities of reducing viral loads in COVID-19 treatment
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536545/
ID  - 7790664
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) was first identified in late 2019 in Wuhan, Hubei Province, China and spread globally in months, sparking worldwide concern. However, it is unclear whether super-spreading events occurred during the early outbreak phase, as has been observed for other emerging viruses. Here, we analyse 208 publicly available SARS-CoV-2 genome sequences collected during the early outbreak phase. We combine phylogenetic analysis with Bayesian inference under an epidemiological model to trace person-to-person transmission. The dispersion parameter of the offspring distribution in the inferred transmission chain was estimated to be 0.23 (95% CI: 0.13-0.38), indicating there are individuals who directly infected a disproportionately large number of people. Our results showed that super-spreading events played an important role in the early stage of the COVID-19 outbreak.
AD  - CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China.
School of Life Sciences and Department of Statistics, University of Warwick, Coventry, CV4 7AL, UK.
Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China.
Département de microbiologie-infectiologie et d'immunologie, Université Laval, Québec City, QC, G1V 0A6, Canada.
University of Chinese Academy of Sciences, Beijing, 101408, China.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Center for Influenza Research and Early-warning (CASCIRE), CAS-TWAS Center of Excellence for Emerging Infectious Diseases (CEEID), Chinese Academy of Sciences, Beijing, 100101, China. beeyh@im.ac.cn.
University of Chinese Academy of Sciences, Beijing, 101408, China. beeyh@im.ac.cn.
Shenzhen Key Laboratory of Pathogen and Immunity, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People's Hospital, Shenzhen, 518112, China. beeyh@im.ac.cn.
AN  - 33024095
AU  - Wang, L.
AU  - Didelot, X.
AU  - Yang, J.
AU  - Wong, G.
AU  - Shi, Y.
AU  - Liu, W.
AU  - Gao, G. F.
AU  - Bi, Y.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41467-020-18836-4
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Nature communications
LA  - eng
N1  - 2041-1723
Wang, Liang
Didelot, Xavier
Yang, Jing
Wong, Gary
Shi, Yi
Orcid: 0000-0002-3053-2687
Liu, Wenjun
Gao, George F
Orcid: 0000-0002-3869-615x
Bi, Yuhai
Orcid: 0000-0002-5595-363x
32041010/National Natural Science Foundation of China (National Science Foundation of China)/
Journal Article
England
Nat Commun. 2020 Oct 6;11(1):5006. doi: 10.1038/s41467-020-18836-4.
PY  - 2020
SN  - 2041-1723
SP  - 5006
ST  - Inference of person-to-person transmission of COVID-19 reveals hidden super-spreading events during the early outbreak phase
T2  - Nature communications
TI  - Inference of person-to-person transmission of COVID-19 reveals hidden super-spreading events during the early outbreak phase
VL  - 11
ID  - 7790841
ER  - 

TY  - JOUR
AU  - Wang, Gary X.
AU  - Chou, Shinn-Huey S.
AU  - Lamb, Leslie R.
AU  - Narayan, Anand K.
AU  - Dontchos, Brian N.
AU  - Lehman, Constance D.
AU  - Miles, Randy C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Opportunities for Radiology Trainee Education Amid the COVID-19 Pandemic: Lessons from an Academic Breast Imaging Program
T2  - Academic Radiology
TI  - Opportunities for Radiology Trainee Education Amid the COVID-19 Pandemic: Lessons from an Academic Breast Imaging Program
UR  - https://doi.org/10.1016/j.acra.2020.09.009
ID  - 7793259
ER  - 

TY  - JOUR
AB  - March through May 2020, a model of novel coronavirus (COVID-19) disease progression and treatment was constructed for the open-source Synthea patient simulation The model was constructed using three peer-reviewed publications published in the early stages of the global pandemic, when less was known, along with emerging resources, data, publications, and clinical knowledge The simulation outputs synthetic Electronic Health Records (EHR), including the daily consumption of Personal Protective Equipment (PPE) and other medical devices and supplies For this simulation, we generated 124,150 synthetic patients, with 88,166 infections and 18,177 hospitalized patients Patient symptoms, disease severity, and morbidity outcomes were calibrated using clinical data from the peer-reviewed publications 4 1% of all simulated infected patients died and 20 6% were hospitalized At peak observation, 548 dialysis machines and 209 mechanical ventilators were needed This simulation and the resulting data have been used for the development of algorithms and prototypes designed to address the current or future pandemics, and the model can continue to be refined to incorporate emerging COVID-19 knowledge, variations in patterns of care, and improvement in clinical outcomes The resulting model, data, and analysis are available as open-source code on GitHub and an open-access data set is available for download
AU  - Walonoski, Jason
AU  - Klaus, Sybil
AU  - Granger, Eldesia
AU  - Hall, Dylan
AU  - Gregorowicz, Andy
AU  - Gregorowicz, Andy
AU  - Neyarapally, George
AU  - Watson, Abigail
AU  - Eastman, Jeff
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Synthea? Novel Coronavirus (COVID-19) Model and Synthetic Data Set
T2  - Intelligence-Based Medicine
TI  - Synthea? Novel Coronavirus (COVID-19) Model and Synthetic Data Set
UR  - https://doi.org/10.1016/j.ibmed.2020.100007
ID  - 7793165
ER  - 

TY  - JOUR
AB  - This paper conceptualises practice in the space between and beyond Art &amp; Archaeology as a zone where disciplinary certainties and known practices are unsettled, expanded and re-cast We will outline our current thinking about heritage landscapes as places and temporalities for engagement in the practice of what Henk Slager calls the para-archive For us, landscape functions as a kind of living archive, however, following Jacques Derrida, we are sceptical of the privileged relation between archive, law and authority Therefore, in this paper we will think through our interdisciplinary research in the context of the development of creative para-archives, which facilitate new, affective ways of thinking and making by bringing together the previously unimagined Responding to the challenge of the SARS-CoV-2 discomfort zone, we seek to surface creative practices, activate archival disruptions and expand pedagogical approaches to the articulation of uncomfortable archival landscapes The pandemic has brought into sharp focus the need to re-conceptualise visions of space, experiences of place and archival practices During a virtual fieldtrip students accessed a range of materials from Scotland?s National Record of the Historic Environment We aimed to enable the co-design and co-production of a virtual fieldtrip, followed by discussions about our collective conceptualisations of landscapes of discomfort The archaeological fieldwork in the virtual realm provides a context for students to engage in desirology as a catalyst for deranging, re-associating and re-imagining the archive in creative ways
AU  - Wall, Gina
AU  - Hale, Alex
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Art & Archaeology: Uncomfortable Archival Landscapes
T2  - International Journal of Art & Design Education
TI  - Art & Archaeology: Uncomfortable Archival Landscapes
UR  - https://doi.org/10.1111/jade.12316
ID  - 7792873
ER  - 

TY  - JOUR
AB  - The current COVID-19 pandemic has prompted the urgent requirement for searching effective treatments since the implications are so huge globally as compared to the earlier pandemics. Momentarily, there has been no effective medicine for SARS-CoV-2 infection, and supportive care tends to be the most effective approach to treat COVID-19 patients. The rapidly growing awareness of SARS-CoV-2 virology offers a large number of possible drug targets. The World Health Organisation (WHO) is steadily updating the treatment protocol for COVID-19 based on the recent clinical trials. In the present review, we have summarised the possible mode of action, clinical evidence, consequences of the dexamethasone as a therapeutic agent against Covid-19. Currently, there are many corticosteroids tested in ongoing randomised trials. Dexamethasone could come as a lifesaving drug. Dexamethasone drug looks useful only in those patients who are already in a critical state. We might allow dexamethasone as a fascinating shot if the long-term health effects of Covid-19 recovered patients safeguard favourable clinical meanings. It is commonly accepted to reinforce approved drugs in the fight against newly emerging diseases such as COVID-19 as these drugs have established pharmacokinetic profiles and protection. The current focus should be on the development of novel proven therapeutics along with vaccines. High-quality, more extensive, rapid and collaborative randomised controlled trials, with more control groups, would be required to include conclusive evidence to ensure and evaluate what works.
AD  - College of Pharmacy, King Khalid University, Abha. Saudi Arabia.
College of Applied Medical Sciences, King Khalid University, Abha. Saudi Arabia.
Faculty of Pharmacy, Integral University, Lucknow. India.
Department of Pharmacology, School of Medicine, Maldives National University. Maldives.
AN  - 33023445
AU  - Wahab, S.
AU  - Ahmad, I.
AU  - Usmani, S.
AU  - Ahmad, M. P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.2174/1567201817666201006144008
DP  - NLM
ET  - 2020/10/08
J2  - Current drug delivery
KW  - Covid-19
Cytokine storm
Dexamethasone
Pandemic
Treatment
LA  - eng
N1  - 1875-5704
Wahab, Shadma
Ahmad, Irfan
Usmani, Shazia
Ahmad, Md Parwez
Journal Article
United Arab Emirates
Curr Drug Deliv. 2020 Oct 6. doi: 10.2174/1567201817666201006144008.
PY  - 2020
SN  - 1567-2018
ST  - Epidemiological Situation and Efficacy of Dexamethasone for the treatment planning of COVID-19: A perspective review
T2  - Current drug delivery
TI  - Epidemiological Situation and Efficacy of Dexamethasone for the treatment planning of COVID-19: A perspective review
ID  - 7790909
ER  - 

TY  - JOUR
AB  -: E-cigarette or vaping, product associated lung injury is a rampant public health issue with a total of 2807 reported hospitalized patients in the United States as of February 18, 2020. Limited data, non-specific symptoms, non-responsiveness to antibiotics, and the lack of a specific biomarker, make it a diagnosis of exclusion. Overlap of clinical and imaging findings with other ongoing respiratory illness (MERS, SARS and CoVid-19) poses a challenge in accurate diagnosis. We compiled 3 cases of patients hospitalized with confirmed vaping-associated lung injury and analyzed their imaging patterns, which revealed bilateral consolidation, ground-glass opacities and pleural effusions. We also reviewed the available literature on pathophysiology, imaging findings of EVALI and other respiratory illness.
AD  - Department of Radiology, University of Arkansas for Medical Sciences, Little Rock, AK (GKV, RP); Department of Internal Medicine, John H Stroger Cook County Hospital, Chicago, IL (NPB, IV, SR); CHI St. Vincent's Infirmary, Little Rock, AK (BB, LS).
AN  - 33021553
AU  - Vilanilam, G. K.
AU  - Purushothaman, R.
AU  - Baskaran, N. P.
AU  - Vohra, I.
AU  - Raghavan, S.
AU  - Bean, B.
AU  - Sajovitz, L.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1097/adm.0000000000000754
DP  - NLM
ET  - 2020/10/07
J2  - Journal of addiction medicine
LA  - eng
N1  - 1935-3227
Vilanilam, George Koshy
Purushothaman, Rangarajan
Baskaran, Naveen Prasath
Vohra, Ishaan
Raghavan, Sairam
Bean, Brian
Sajovitz, Lisa
Journal Article
United States
J Addict Med. 2020 Oct 5. doi: 10.1097/ADM.0000000000000754.
PY  - 2020
SN  - 1932-0620
ST  - Imaging in Vaping-associated Lung Injury: Beyond the Haze
T2  - Journal of addiction medicine
TI  - Imaging in Vaping-associated Lung Injury: Beyond the Haze
ID  - 7791022
ER  - 

TY  - JOUR
AU  - Vielitz, Arne
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A Safety Net for Patients in Times of COVID-19
T2  - Manuelle Therapie
TI  - A Safety Net for Patients in Times of COVID-19
UR  - https://doi.org/10.1055/a-1220-0817
ID  - 7793487
ER  - 

TY  - JOUR
AB  - BACKGROUND: Strong epidemiologic evidence has highlighted the role of pollution, on top of adverse climate features, as a novel cardiovascular risk factor. However, mechanistic proof that reducing pollution may be beneficial to prevent atherothrombotic events is limited. We aimed at appraising the impact of temporary traffic bans in a large metropolitan area on the risk of acute coronary syndromes. METHODS: Aggregate and anonymized data from 15 tertiary cardiac care centers were obtained detailing pre-coronarivus disease 2019 (COVID-19) daily cases of ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI), including those treated with percutaneous coronary intervention (PCI). Data on pollutants and climate were sought for the same days. Mixed level regression was used to compare the week before vs after the traffic ban (Fortnight analysis), the 3 days before vs after (Weekly analysis) and the Sunday before vs after (Sunday analysis). RESULTS: A total of 8 days of temporary traffic bans were included, occurring between 2017 and 2020, totaling 802 STEMI and 1196 NSTEMI in the Fortnight analysis, 382 STEMI and 585 in the Weekly analysis, and 148 STEMI and 210 NSTEMI in the Sunday analysis. Fortnight and Sunday analysis did not disclose a significant impact of traffic ban on STEMI or NSTEMI (all p0.05). Conversely, Weekly analysis showed non-significant changes for STEMI but a significant decrease in daily NSTEMI when comparing the 3 days before the traffic ban with the ban day (p=0.043), as well as the 3 days before vs the 3 days after the ban (p=0.025). No statistically significant effect of traffic ban was found at Fortnight, Weekly or Sunday analyses for daily mean concentrations of benzene, carbon monoxide, nitric oxide, nitrogen dioxide, ozone, sulfur dioxide, particulate matter (PM) 2.5 μm or PM 10 μm (all p0.05). However, minimum daily concentrations showed a significant reduction of ozone during the ban in comparison to the week preceding it (p=0.034), nitric oxide during the ban in comparison to the 3 days preceding it (p=0.046), and an increase in benzene during the ban in comparison to the Sunday before (p=0.039). CONCLUSIONS: Temporary traffic ban may favorably reduce coronary atherothrombotic events, and in particular NSTEMI, even if not globally and immediately impacting on environmental pollution. Further controlled studies are required to confirm and expand this hypothesis-generating results.
AD  - UOC UTIC, Emodinamica e Cardiologia, Ospedale S. Maria Goretti, Latina, Italy.
Division of Cardiology, S. Eugenio, Hospital, Rome, Italy.
Division of Cardiology, S. Spirito Hospital, Rome, Italy.
D ivision of Cardiology, G. B. Grassi, Hospital, Lido di Ostia, Rome, Italy.
Department of Clinical, Internal, Anesthesiology and Cardiovascular Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Chair of Cardiology, Tor Vergata University, Rome, Italy.
Interventional Cardiology Unit, San Pietro Fatebenefratelli Hospital, Rome, Italy.
Interventional Cardiology Unit, San Camillo Hospital, Rome, Italy.
Division of Cardiology, M. G. Vannini Hospital, Rome, Italy.
Department of, Cardiovascular Diseases, Sant'Andrea Hospital, Rome, Italy.
Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, Italy.
Division of Cardiology, Policlinico Casilino, Rome, Italy.
Division of Cardiology, S. Filippo, Hospital, Rome, Italy.
Division of Cardiology, Aurelia Hospital, Rome, Italy.
ARPA Lazio, Rome, Italy.
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.
IRCCS Neuromed, Pozzilli, Isernia, Italy.
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy - giuseppe.biondizoccai@uniroma1.it.
Mediterranea Cardiocentro, Naples, Italy.
AN  - 33021366
AU  - Versaci, F.
AU  - Gaspardone, A.
AU  - Danesi, A.
AU  - Ferranti, F.
AU  - Mancone, M.
AU  - Mariano, E.
AU  - Rotolo, F.
AU  - Musto, C.
AU  - Proietti, I.
AU  - Berni, A.
AU  - Trani, C.
AU  - Sergi, S. C.
AU  - Speciale, G.
AU  - Tanzilli, G.
AU  - Tomai, F.
AU  - Di Giosa, A.
AU  - Marchegiani, G.
AU  - Calcagno, S.
AU  - Romagnoli, E.
AU  - Frati, G.
AU  - Biondi-Zoccai, G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.23736/s0031-0808.20.04161-0
DP  - NLM
ET  - 2020/10/07
J2  - Panminerva medica
LA  - eng
N1  - 1827-1898
Versaci, Francesco
Gaspardone, Achille
Danesi, Alessandro
Ferranti, Fabio
Mancone, Massimo
Mariano, Enrica
Rotolo, Francesco
Musto, Carmine
Proietti, Igino
Berni, Andrea
Trani, Carlo
Sergi, Sonia C
Speciale, Giulio
Tanzilli, Gaetano
Tomai, Fabrizio
Di Giosa, Alessandro
Marchegiani, Giada
Calcagno, Simone
Romagnoli, Enrico
Frati, Giacomo
Biondi-Zoccai, Giuseppe
Journal Article
Italy
Panminerva Med. 2020 Oct 6. doi: 10.23736/S0031-0808.20.04161-0.
PY  - 2020
SN  - 0031-0808
ST  - Impact of temporary traffic bans on the risk of acute coronary syndromes in a large metropolitan area
T2  - Panminerva medica
TI  - Impact of temporary traffic bans on the risk of acute coronary syndromes in a large metropolitan area
ID  - 7791035
ER  - 

TY  - JOUR
AB  - COVID-19 is a global healthcare pandemic that is now growing through nations across the world. The role of radiology is crucial, and a variety of guidelines have been published regarding the role of imaging. These aim to protect healthcare workers (HCWs) and the general public from exposure, while preserving critical radiology operations and conserving personal protective equipment (PPE) and other critical care resources during the COVID-19 pandemic. Fleischner Society published guidelines on indications of imaging various settings. These guidelines take into account resource availability, pre-test probability, degree of symptoms and risk factors, which is crucial for decision-making regarding need and indications of imaging. Mitigating steps and alternative approaches should be considered to provide the best care for patients while protecting all HCWs. Owing to overlap of COVID-19 imaging findings with other pathologies, standardized reporting acquires importance for risk assessment and effective communication of suspicious findings. RSNA followed by Dutch Radiological Society (NVvR) have published guidelines on standardized CT reporting for COVID-19, which show excellent inter-observer variability. Standardized reporting can provide guidance and confidence to radiologists as well as increased clarity to physicians through reduced reporting variability. The article discusses the published recommendations and aims to make radiologists aware of the protocols and guidelines that need to be followed in this ongoing public health crisis for effective patient care while protecting HCWs and conserving resources.
AD  - All India Institute of Medical Sciences, Virbhadra Road, Rishikesh, India. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103
Post Graduate Institute of Medical Education and Research, Sector-12, Chandigarh, India. GRID: grid.415131.3. ISNI: 0000 0004 1767 2903
Government Medical College, Circular Road, Amritsar, India. GRID: grid.413222.4. ISNI: 0000 0004 1801 2595
AN  - 33024936
AU  - Vermani, S.
AU  - Kaushal, A.
AU  - Kaushal, J.
C1  - 10/7/2020
C2  - PMC7529467
DA  - Oct 2
DB  - PubMed
DO  - 10.1007/s42399-020-00554-z
DP  - NLM
ET  - 2020/10/08
J2  - SN comprehensive clinical medicine
KW  - Covid-19
Coronavirus
Imaging
Pandemics
Radiology
LA  - eng
N1  - 2523-8973
Vermani, Sanya
Kaushal, Aditya
Kaushal, Jessica
Journal Article
Review
Switzerland
SN Compr Clin Med. 2020 Oct 2:1-7. doi: 10.1007/s42399-020-00554-z.
PY  - 2020
SN  - 2523-8973
SP  - 1-7
ST  - COVID-19 and the Radiology Department: What We Know So Far
T2  - SN comprehensive clinical medicine
TI  - COVID-19 and the Radiology Department: What We Know So Far
ID  - 7790758
ER  - 

TY  - JOUR
AB  - PURPOSE: COVID-19 raises D-dimer (DD) levels even in the absence of pulmonary embolism (PE), resulting in an increase in computed tomography pulmonary angiogram (CTPA) requests. Our purpose is to determine whether there are differences between DD values in PE-positive and PE-negative COVID-19 patients and, if so, to establish a new cutoff value which accurately determines when a CTPA is needed. METHODS: This study retrospectively analyzed all COVID-19 patients who underwent a CTPA due to suspected PE between March 1 and April 30, 2020, at Ram�Qn y Cajal University Hospital, Madrid (Spain). DD level comparisons between PE-positive and PE-negative groups were made using Student's t test. The optimal DD cutoff value to predict PE risk in COVID-19 patients was calculated in the ROC curve. RESULTS: Two hundred forty-two patients were included in the study. One hundred fifty-one (62%) were men and the median age was 68 years (IQR 55-78). An increase of DD (median 3260; IQR 1203-9625 ng/mL) was detected in 205/242 (96%) patients. 73/242 (30%) of the patients were diagnosed with PE on CTPA. The DD median value was significantly higher (p �?001) in the PE-positive group (7872, IQR 3150-22,494 ng/mL) compared with the PE-negative group (2009, IQR 5675-15,705 ng/mL). The optimal cutoff value for DD to predict PE was 2903 ng/mL (AUC was 0.76 [CI 95% 0.69-0.83], sensitivity 81%). The overall mortality rate was 16% (39/242). CONCLUSION: A higher threshold (2903 ng/mL) for D-dimer could predict the risk of PE in COVID-19 patients with a sensitivity of 81%.
AD  - Radiology Department, Ram�Qn y Cajal University Hospital Ctra, de Colmenar Viejo km. 9,100, 28034, Madrid, Spain. sofi9417vd@gmail.com.
Radiology Department, Ram�Qn y Cajal University Hospital Ctra, de Colmenar Viejo km. 9,100, 28034, Madrid, Spain.
Radiology Department, Chest Radiology Section, Ram�Qn y Cajal University Hospital Ctra, de Colmenar Viejo km. 9,100, 28034, Madrid, Spain.
Radiology Department, Emergency Radiology Section, Ram�Qn y Cajal University Hospital Ctra, de Colmenar Viejo km. 9,100, 28034, Madrid, Spain.
AN  - 33025219
AU  - Ventura-D�Taz, S.
AU  - Quintana-Pérez, J. V.
AU  - Gil-Boronat, A.
AU  - Herrero-Huertas, M.
AU  - Gorospe-Sarasúa, L.
AU  - Montilla, J.
AU  - Acosta-Batlle, J.
AU  - Bl֙zquez-S֙nchez, J.
AU  - Vicente-B֙rtulos, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s10140-020-01859-1
DP  - NLM
ET  - 2020/10/08
J2  - Emergency radiology
KW  - Covid-19
Computed tomography pulmonary angiogram
D-dimer
Pulmonary embolism
Retrospective study
LA  - eng
N1  - 1438-1435
Ventura-D�Taz, Sof�Ta
Orcid: 0000-0002-6541-7910
Quintana-Pérez, Juan V
Gil-Boronat, Almudena
Herrero-Huertas, Marina
Gorospe-Sarasúa, Luis
Montilla, José
Acosta-Batlle, J�Qse
Bl֙zquez-S֙nchez, Javier
Vicente-B֙rtulos, Agustina
Journal Article
United States
Emerg Radiol. 2020 Oct 6. doi: 10.1007/s10140-020-01859-1.
PY  - 2020
SN  - 1070-3004
ST  - A higher D-dimer threshold for predicting pulmonary embolism in patients with COVID-19: a retrospective study
T2  - Emergency radiology
TI  - A higher D-dimer threshold for predicting pulmonary embolism in patients with COVID-19: a retrospective study
ID  - 7790718
ER  - 

TY  - JOUR
AB  - The newly emerged coronavirus (severe acute respiratory syndrome coronavirus 2 SARS-CoV-2) and the disease that it causes coronavirus disease 2019 (COVID-19) have changed the world we know. Yet, the origin and evolution of SARS-CoV-2 remain mostly vague. Many virulence factors and immune mechanisms contribute to the deteriorating effects on the organism during SARS-CoV-2 infection. Both humoral and cellular immune responses are involved in the pathophysiology of the disease, where the principal and effective immune response towards viral infection is the cell-mediated immunity. The clinical picture of COVID-19, which includes immune memory and reinfection, remains unclear and unpredictable. However, many hopes are put in developing an effective vaccine against the virus, and different therapeutic options have been implemented to find effective, even though not specific, treatment to the disease. We can assume that the interaction between the SARS-CoV-2 virus and the individual's immune system determines the onset and development of the disease significantly.
AD  - Department of Clinical Immunology, University Hospital Lozenetz, Sofia 1407, Bulgaria. tsvelikova@medfac.mu-sofia.bg.
Department of Infectious Diseases, Pazardzhik Multiprofile Hospital for Active Treatment, Pazardzhik 4400, Bulgaria.
Dental Faculty, Medical University of Plovdiv, Plovdiv 4002, Bulgaria.
Department of Epidemiology and Disaster Medicine, Medical University, Plovdiv, University Hospital "St George", Plovdiv 4002, Bulgaria.
AN  - 33024515
AU  - Velikova, T. V.
AU  - Kotsev, S. V.
AU  - Georgiev, D. S.
AU  - Batselova, H. M.
C1  - 10/7/2020
C2  - PMC7520644
DA  - Sep 27
DB  - PubMed
DO  - 10.4331/wjbc.v11.i2.14
DP  - NLM
ET  - 2020/10/08
IS  - 2
J2  - World journal of biological chemistry
KW  - Anti-SARS-CoV-2 antibodies
Covid-19
COVID-19 treatment
Immune memory
Plasma therapy
SARS-CoV-2
LA  - eng
N1  - Velikova, Tsvetelina Veselinova
Kotsev, Stanislav Vasilev
Georgiev, Daniel Stefanov
Batselova, Hristiana Momchilova
Journal Article
Review
United States
World J Biol Chem. 2020 Sep 27;11(2):14-29. doi: 10.4331/wjbc.v11.i2.14.
PY  - 2020
SN  - 1949-8454 (Print)
1949-8454
SP  - 14-29
ST  - Immunological aspects of COVID-19: What do we know?
T2  - World journal of biological chemistry
TI  - Immunological aspects of COVID-19: What do we know?
VL  - 11
ID  - 7790789
ER  - 

TY  - JOUR
AB  - As cases rise across western Europe, are second lockdowns inevitable and what should they look like? Adam Vaughan reports
AU  - Vaughan, Adam
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - How best to lockdown again
T2  - New Scientist
TI  - How best to lockdown again
UR  - https://doi.org/10.1016/S0262-4079(20)31731-0
ID  - 7792686
ER  - 

TY  - JOUR
AU  - Vandrevala, Tushna
AU  - Montague, Amy
AU  - Terry, Philip
AU  - Fielder, Mark
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - COVID-19, Coronavirus, testing, risk perception, public
PY  - 2020
ST  - Willingness of the UK Public to Volunteer for Testing in Relation to the COVID-19 Pandemic (preprint)
T2  - SSRN
TI  - Willingness of the UK Public to Volunteer for Testing in Relation to the COVID-19 Pandemic (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3675401
ID  - 7794797
ER  - 

TY  - JOUR
AU  - VanDoren, Peter
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - public health, COVID-19, coronavirus, pandemic, pandemic policy, pandemic response, public health officials, scientific advisory council, scientific recommendations
PY  - 2020
ST  - When and How We Should 'Trust the Science' (preprint)
T2  - SSRN
TI  - When and How We Should 'Trust the Science' (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3694665
ID  - 7794789
ER  - 

TY  - JOUR
AU  - van Leeuwen, Marco
AU  - Klerks, Yvonne
AU  - Bargeman, Bertine
AU  - Heslinga, Jasper
AU  - Bastiaansen, Marcel
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Leisure will not be locked down �?insights on leisure and COVID-19 from the Netherlands
T2  - World Leisure Journal
TI  - Leisure will not be locked down �?insights on leisure and COVID-19 from the Netherlands
UR  - https://doi.org/10.1080/16078055.2020.1825255
ID  - 7792951
ER  - 

TY  - JOUR
AD  - Department of Laboratory Medicine, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands.
Department of Intensive Care Medicine, Radboud University Medical Centre, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.
Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands.
Department of Intensive Care Medicine, Radboud University Medical Centre, Postbus 9101, 6500 HB, Nijmegen, The Netherlands. jeroen.schouten@radboudumc.nl.
Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500 HB, Nijmegen, The Netherlands. jeroen.schouten@radboudumc.nl.
AN  - 33023606
AU  - van Berkel, M.
AU  - Kox, M.
AU  - Frenzel, T.
AU  - Pickkers, P.
AU  - Schouten, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13054-020-03291-w
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Critical care (London, England)
KW  - Antimicrobial stewardship
Covid-19
Procalcitonin
LA  - eng
N1  - 1466-609x
van Berkel, Miranda
Kox, Matthijs
Frenzel, Tim
Pickkers, Peter
Schouten, Jeroen
Orcid: 0000-0001-9118-4420
RCI-COVID-19 study group
Journal Article
England
Crit Care. 2020 Oct 6;24(1):600. doi: 10.1186/s13054-020-03291-w.
PY  - 2020
SN  - 1364-8535
SP  - 600
ST  - Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?
T2  - Critical care (London, England)
TI  - Biomarkers for antimicrobial stewardship: a reappraisal in COVID-19 times?
VL  - 24
ID  - 7790899
ER  - 

TY  - JOUR
AB  - Problem When WHO declared COVID-19 “international�? it was important not to damage some critical patients who need emergency procedures like organ transplantation, due to end stage organ disease In 2003 SARS outbreak demonstrated the vulnerability of organ transplantation services o network Descritption If transplantation is required as a life-saving procedure, it can be conducted with appropriate risk infection assessment It is crucial during these emergencies to assess donor pool, as it is expected to decrease A crucial point is to organize and evaluate the surge capacity, in terms of understaffing and lack of supplies, especially in ICU The research methods were literature review using Pub Med, CDC, ECDC, WHO, TTS, searching as key words “SARS-CoV-2�? “COVID-19�? “transplantation�? “preparedness�?The analysis has been conducted between Feb 26th 2020 and March 5th 2020 Results As happened during SARS breakout in 2003, it is essential to establish a task force for crisis, currently updated and skilled for this particular management Preparedness should regard especially the adoption of donor safety assessment procedures, ICU capability, the availability of covid-19 test for all the donors, and the adoption of specific post-transplant care It is essential in this case establish preparedness in several points: education and training of the staff, practice drills, inspection of supplies, evaluation of surge capacity, relocation of patients Lessons SARS-CoV-2 imposed in public health to establish new protocols and guidelines, which should be regularly updated to be useful in other epidemics outbreaks or other emergency situation These protocols should focus on donor pool and ICU capability in order to carry on transplantation activities Key messages This outbreak has tested the resilience of the whole system by day-by-day updating for transplantation teams and preparedness of the staff involved in transplantation management During outbreak, seems to be useful a task force for crisis in order to support organ transplantation services
AU  - Valdi, G.
AU  - Varadi, G.
AU  - Panzera, A.
AU  - Parpinel, M.
AU  - Peressutti, R.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Preparedness for transplantation during COVID-19 outbreak: how to manage?
T2  - European Journal of Public Health
TI  - Preparedness for transplantation during COVID-19 outbreak: how to manage?
UR  - https://doi.org/10.1093/eurpub/ckaa166.607
ID  - 7792906
ER  - 

TY  - JOUR
AU  - Vajer, P.
AU  - Csenteri, O.
AU  - Szab�Q, J.
AU  - Tam֙s, F.
AU  - Kalabay, L.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - H֙ziorvosl֙s a COVID-19-j֙rv֙ny idején
T2  - Orv Hetil
TI  - H֙ziorvosl֙s a COVID-19-j֙rv֙ny idején
UR  - https://doi.org/10.1556/650.2020.31954
ID  - 7792782
ER  - 

TY  - JOUR
AB  - In this study, we characterize the impacts of COVID-19 on air pollution using NO(2) and Aerosol Optical Depth (AOD) from TROPOMI and MODIS satellite datasets for 41 cities in India. Specifically, our results suggested a 13% NO(2) reduction during the lockdown (March 25-May 3rd, 2020) compared to the pre-lockdown (January 1st-March 24th, 2020) period. Also, a 19% reduction in NO(2) was observed during the 2020-lockdown as compared to the same period during 2019. The top cities where NO(2) reduction occurred were New Delhi (61.74%), Delhi (60.37%), Bangalore (48.25%), Ahmedabad (46.20%), Nagpur (46.13%), Gandhinagar (45.64) and Mumbai (43.08%) with less reduction in coastal cities. The temporal analysis revealed a progressive decrease in NO(2) for all seven cities during the 2020 lockdown period. Results also suggested spatial differences, i.e., as the distance from the city center increased, the NO(2) levels decreased exponentially. In contrast, to the decreased NO(2) observed for most of the cities, we observed an increase in NO(2) for cities in Northeast India during the 2020 lockdown period and attribute it to vegetation fires. The NO(2) temporal patterns matched the AOD signal; however, the correlations were poor. Overall, our results highlight COVID-19 impacts on NO(2), and the results can inform pollution mitigation efforts across different cities of India.
AD  - NASA Marshall Space Flight Center, Huntsville, AL, 35811, USA. krishna.p.vadrevu@nasa.gov.
University of Alabama in Huntsville, Huntsville, AL, USA.
Smithsonian Conservation Biology Institute, Front Royal, VA, USA.
US Army Corps of Engineers, Alexandria, VA, USA.
Utkal University, Bhubaneswar, Odisha, India.
Tata Energy Research Institute (TERI) School of Advanced Studies, New Delhi, India.
University of Maryland, College Park, MD, USA.
AN  - 33024128
AU  - Vadrevu, K. P.
AU  - Eaturu, A.
AU  - Biswas, S.
AU  - Lasko, K.
AU  - Sahu, S.
AU  - Garg, J. K.
AU  - Justice, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-72271-5
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Vadrevu, Krishna Prasad
Eaturu, Aditya
Biswas, Sumalika
Lasko, Kristofer
Sahu, Saroj
Garg, J K
Justice, Chris
281945.02.58.03.01/NASA/NASA/United States
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16574. doi: 10.1038/s41598-020-72271-5.
PY  - 2020
SN  - 2045-2322
SP  - 16574
ST  - Spatial and temporal variations of air pollution over 41 cities of India during the COVID-19 lockdown period
T2  - Scientific reports
TI  - Spatial and temporal variations of air pollution over 41 cities of India during the COVID-19 lockdown period
VL  - 10
ID  - 7790838
ER  - 

TY  - JOUR
AB  - ABSTRACT A novel coronavirus, SARS-COV-2, related infection is thought to have originated in Wuhan, China, in November 2019 but spread rapidly to be declared a global pandemic by the WHO in March 2020 The patients typically present with fever and shortness of breath We describe a case of spontaneous pneumomediastinum at presentation as a complication of severe Covid-19 infection A 54 year old male patient with no history of smoking, asthma or other underlying chronic lung disease, presented to our emergency department with severe Covid-19 symptoms His chest x-ray and CT scan on arrival at the emergency department, and prior to any intervention, demonstrated severe bilateral Covid-19 pneumonia complicated by a pneumomediastinum The aetiology of the pneumomediastinum is thought to be a direct complication of severe covid-19 pneumonia in absence of any previous respiratory history or iatrogenic cause
AU  - Urigo, Carlo
AU  - Soin, Susanne
AU  - Sahu, Ajay
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - SPONTANEOUS PNEUMOMEDIASTINUM AS A COMPLICATION OF A COVID-19 RELATED PNEUMONIA: CASE REPORT AND REVIEW OF LITERATURE
T2  - Radiology Case Reports
TI  - SPONTANEOUS PNEUMOMEDIASTINUM AS A COMPLICATION OF A COVID-19 RELATED PNEUMONIA: CASE REPORT AND REVIEW OF LITERATURE
UR  - https://doi.org/10.1016/j.radcr.2020.09.052
ID  - 7793072
ER  - 

TY  - GEN
AN  - NCT04578236
AU  - University, Kafrelsheikh
C1  - 10/7/2020
DA  - November
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19
N1  - No Results Available
Combination Product: Aerosolized 13 cis retinoic acid plus Inhalation administration by nebulization captopril 25mg|Drug: Drug: Standard treatment Standard treatment
lung injury score|Transe membrane protease ,serine II (TMPRSS2) changes over time|Testosterone levels changes over time|Dihydrotestosterone(DHT) levels changes over time|Cholesterol levels changes over time|Angiotensin 1-7 (Ang 1-7) changes over time|Angiotensin 1-5 (Ang 1-5) changes over time|Renin changes over time|Aldosterone changes over time|Angiotensin-converting enzyme (ACE) changes over time|Time to first negative SARS-CoV-2 PCR in NP swap|All cause mortality rate|Ventilation free days|ICU free days
All
Phase 2
360
Other
Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
SARS
January 2021
PB  - https://ClinicalTrials.gov/show/NCT04578236
PY  - 2020
ST  - Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)
T2  - ClinicalTrials
TI  - Efficacy of Aerosol Combination Therapy of 13 Cis Retinoic Acid and Captopril for Treating Covid-19 Patients Via Indirect Inhibition of Transmembrane Protease, Serine 2 (TMPRSS2)
UR  - https://ClinicalTrials.gov/show/NCT04578236
ID  - 7794701
ER  - 

TY  - JOUR
AU  - Underner, M.
AU  - Perriot, J.
AU  - Peiffer, G.
AU  - Jaafari, N.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19, tuberculose et mortalité induite
T2  - Revue des Maladies Respiratoires
TI  - COVID-19, tuberculose et mortalité induite
UR  - https://doi.org/10.1016/j.rmr.2020.09.006
ID  - 7793059
ER  - 

TY  - JOUR
AB  - The present study aims to design stochastic intelligent computational heuristics for the numerical treatment of a nonlinear SITR system representing the dynamics of novel coronavirus disease 2019 (COVID-19) The mathematical SITR system using fractal parameters for COVID-19 dynamics is divided into four classes;that is, susceptible (S), infected (I), treatment (T), and recovered (R) The comprehensive details of each class along with the explanation of every parameter are provided, and the dynamics of novel COVID-19 are represented by calculating the solution of the mathematical SITR system using feed-forward artificial neural networks (FF-ANNs) trained with global search genetic algorithms (GAs) and speedy fine tuning by sequential quadratic programming (SQP)&amp;mdash;that is, an FF-ANN-GASQP scheme In the proposed FF-ANN-GASQP method, the objective function is formulated in the mean squared error sense using the approximate differential mapping of FF-ANNs for the SITR model, and learning of the networks is proficiently conducted with the integrated capabilities of GA and SQP The correctness, stability, and potential of the proposed FF-ANN-GASQP scheme for the four different cases are established through comparative assessment study from the results of numerical computing with Adams solver for single as well as multiple autonomous trials The results of statistical evaluations further authenticate the convergence and prospective accuracy of the FF-ANN-GASQP method
AU  - Umar, Muhammad
AU  - Sabir, Zulqurnain
AU  - Raja, Muhammad Asif Zahoor
AU  - Shoaib, Muhammad
AU  - Gupta, Manoj
AU  - S֙nchez, Yolanda Guerrero
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A Stochastic Intelligent Computing with Neuro-Evolution Heuristics for Nonlinear SITR System of Novel COVID-19 Dynamics
T2  - Symmetry
TI  - A Stochastic Intelligent Computing with Neuro-Evolution Heuristics for Nonlinear SITR System of Novel COVID-19 Dynamics
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813275
ID  - 7793329
ER  - 

TY  - JOUR
AB  - There were several studies about the psychiatric and mental health issues related to the severe adult respiratory syndrome (SARS) outbreak in 2003, however, the association between SARS and the overall risk of psychiatric disorders and suicides has, as yet, to be studied in Taiwan. The aim of this study is to examine as to whether SARS is associated with the risk of psychiatric disorders and suicide. A total of 285 patients with SARS and 2850 controls without SARS (1:10) matched for sex, age, insurance premium, comorbidities, residential regions, level of medical care, and index date were selected between February 25 and June 15, 2003 from the Inpatient Database Taiwan's National Health Insurance Research Database. During the 12-year follow-up, in which 79 in the SARS cohort and 340 in the control group developed psychiatric disorders or suicide (4047.41 vs. 1535.32 per 100,000 person-years). Fine and Gray's survival analysis revealed that the SARS cohort was associated with an increased risk of psychiatric disorders and suicide, and the adjusted subdistribution HR (sHR) was 2.805 (95% CI: 2.182-3.605, p �?.001) for psychiatric disorders and suicide. The SARS cohort was associated with anxiety, depression, sleep disorders, posttraumatic stress disorder/acute stress disorder (PTSD/ASD), and suicide. The sensitivity analysis revealed that the SARS group was associated with anxiety, depression, sleep disorders, PTSD/ASD, and suicide after the individuals with a diagnosis of psychiatric disorders and suicide were excluded within the first year, and with anxiety, depression, and sleep disorders, while those in the first five years were excluded. In conclusion, SARS was associated with the increased risk of psychiatric disorders and suicide.
AD  - Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Student Counseling Center, National Defense Medical Center, Taipei, Taiwan.
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
School of Public Health, National Defense Medical Center, Taipei, Taiwan.
Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan.
Department of Psychiatry, Tri-Service General Hospital, Song-Shan Branch, National Defense Medical Center, Taipei, Taiwan.
Division of Pulmonary and Critical Medicine, Department of Medicine, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan.
Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. chienwu@ndmctsgh.edu.tw.
School of Public Health, National Defense Medical Center, Taipei, Taiwan. chienwu@ndmctsgh.edu.tw.
Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan. chienwu@ndmctsgh.edu.tw.
Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan. chienwu@ndmctsgh.edu.tw.
AN  - 33024072
AU  - Tzeng, N. S.
AU  - Chung, C. H.
AU  - Chang, C. C.
AU  - Chang, H. A.
AU  - Kao, Y. C.
AU  - Chang, S. Y.
AU  - Chien, W. C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41398-020-01021-y
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Translational psychiatry
LA  - eng
N1  - 2158-3188
Tzeng, Nian-Sheng
Chung, Chi-Hsiang
Orcid: 0000-0002-4576-9900
Chang, Chuan-Chia
Chang, Hsin-An
Kao, Yu-Chen
Chang, Shan-Yueh
Chien, Wu-Chien
Orcid: 0000-0002-3286-0780
Journal Article
United States
Transl Psychiatry. 2020 Oct 6;10(1):339. doi: 10.1038/s41398-020-01021-y.
PY  - 2020
SN  - 2158-3188
SP  - 339
ST  - What could we learn from SARS when facing the mental health issues related to the COVID-19 outbreak? A nationwide cohort study in Taiwan
T2  - Translational psychiatry
TI  - What could we learn from SARS when facing the mental health issues related to the COVID-19 outbreak? A nationwide cohort study in Taiwan
VL  - 10
ID  - 7790848
ER  - 

TY  - JOUR
AU  - Turnquist, Casmir
AU  - Ryan, Br�Td M.
AU  - Horikawa, Izumi
AU  - Harris, Brent T.
AU  - Harris, Curtis C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Cytokine Storms in Cancer and COVID-19
T2  - Cancer Cell
TI  - Cytokine Storms in Cancer and COVID-19
UR  - https://doi.org/10.1016/j.ccell.2020.09.019
ID  - 7793216
ER  - 

TY  - JOUR
AB  - In the context of the COVID-19 pandemic and the state of emergency that the government of Spain declared, health service providers&#039; rapid adaptation of health services is of paramount importance to preserve access to and continuity of service delivery This commentary underscores the importance of ensuring a sufficient quantity of methadone take-home doses for patients to maximize their adherence to methadone maintenance treatment (MMT) during government-imposed lockdown restrictions and social distancing measures designed to curtail the spread of SARS-CoV-2 We evaluate the impact of COVID-19 on take-home medication (number of days provided) in a methadone clinic in Barcelona (Catalonia, Spain) We propose maintaining the take-home practices that we adopted in response to the pandemic, even after the pandemic has abated
AU  - Trujols, Joan
AU  - Larrabeiti, Antonio
AU  - Sànchez, Oriol
AU  - Madrid, Maite
AU  - De Andrés, Sandra
AU  - Duran-Sindreu, Santiago
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Increased flexibility in methadone take-home scheduling during the COVID-19 pandemic: Should this practice be incorporated into routine clinical care?
T2  - Journal of Substance Abuse Treatment
TI  - Increased flexibility in methadone take-home scheduling during the COVID-19 pandemic: Should this practice be incorporated into routine clinical care?
UR  - https://doi.org/10.1016/j.jsat.2020.108154
ID  - 7793114
ER  - 

TY  - JOUR
AB  - BACKGROUND: Prolonged nucleic acid conversion and false-negative results of real-time polymerase chain reaction (RT-PCR) might occur in COVID-19 patients rather than infection recurrence. PRESENTATION OF CASES: We reported four cases who had negative RT-PCR results, in addition to the last two consecutive negative results. Patient-1 had negative RT-PCR results twice (the 6th and 8th) from a total of 11 swabs. Patient-2 had negative RT-PCR results once (the 5th) from a total of 8 swabs. Patient-3 showed negative results of RT-PCR twice (the 4th and 6th) from a total of 11 swabs. Patient 4 had negative RT-PCR results twice (the 2nd and 10th) from a total of 14 swabs. DISCUSSION: The fluctuating trend of our RT-PCR results in our cases might be due to insufficient viral material in the specimen, laboratory errors during sampling, restrictions on sample transportation, or mutations in the primary and probe target regions in the SARS-CoV-2 genome. Several factors might affect the occurrence of prolonged nucleic acid conversion, including older age, comorbidities, such as diabetes and hypertension, and impaired immune function. CONCLUSION: Here, we confirmed the occurrence of prolonged nucleic acid conversion and the possibility of false negative RT-PCR results in COVID-19.
AN  - PMC7536520
AU  - Trisnawati, Ika
AU  - El Khair, Riat
AU  - Puspitarani, Dyah Ayu
AU  - Fauzi, Aditya Rifqi
AU  - Gunadi
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.amsu.2020.09.040
DP  - NLM
J2  - Ann Med Surg (Lond)
KW  - COVID-19
Case series
False negative of RT-PCR
Prolonged nucleic acid conversion
SARS-Cov-2
LA  - eng
N1  - PMC7536520[pmcid]
S2049-0801(20)30345-9[PII]
PY  - 2020
SN  - 2049-0801
ST  - Prolonged nucleic acid conversion and false-negative RT-PCR results in patients with COVID-19: A case series
T2  - Annals of Medicine and Surgery
TI  - Prolonged nucleic acid conversion and false-negative RT-PCR results in patients with COVID-19: A case series
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536520/
ID  - 7790671
ER  - 

TY  - JOUR
AB  - Since initial identification of severe acute respiratory syndrome coronavirus 2 in 2019, the virus has proved to be highly transmissible, resulting in a global pandemic with emerging reports of infected neonates. This report highlights a severe case of neonatal coronavirus disease 2019 with acute respiratory distress syndrome.
AD  - From the Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
Department of Pediatrics, Children's of Alabama, Birmingham, Alabama.
Division of Pediatric Rheumatology, Department of Pediatrics.
Division of Pediatric Critical Care, Department of Pediatrics.
Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama.
AN  - 33021595
AU  - Trieu, C.
AU  - Poole, C.
AU  - Cron, R. Q.
AU  - Hallman, M.
AU  - Rutledge, C.
AU  - Bliton, K.
AU  - Phillips, A.
AU  - Lawrence, M.
AU  - Boppana, S. B.
AU  - Pinninti, S.
C1  - 10/7/2020
DA  - Aug 12
DB  - PubMed
DO  - 10.1097/inf.0000000000002864
DP  - NLM
ET  - 2020/10/07
J2  - The Pediatric infectious disease journal
LA  - eng
N1  - 1532-0987
Trieu, Connie
Poole, Claudette
Cron, Randy Q
Hallman, Madhura
Rutledge, Chrystal
Bliton, Kyle
Phillips, Adeline
Lawrence, Maggie
Boppana, Suresh B
Pinninti, Swetha
Journal Article
United States
Pediatr Infect Dis J. 2020 Aug 12. doi: 10.1097/INF.0000000000002864.
PY  - 2020
SN  - 0891-3668
ST  - SEVERE NEONATAL CORONAVIRUS DISEASE 2019 PRESENTING AS ACUTE RESPIRATORY DISTRESS SYNDROME
T2  - Pediatric infectious disease journal
TI  - SEVERE NEONATAL CORONAVIRUS DISEASE 2019 PRESENTING AS ACUTE RESPIRATORY DISTRESS SYNDROME
ID  - 7791019
ER  - 

TY  - JOUR
AB  - To understand the real impact of COVID-19 on cancer patients, an entirely new data collection effort was initiated within the Thoracic Cancers International COVID-19 Collaboration (TERAVOLT) TERAVOLT reported high mortality related to COVID-19 infection in thoracic cancer patients and identified several negative prognostic factors In this commentary, we discuss the importance and limits of patient registries to support decision-making in thoracic cancer during the SARS-CoV-2 pandemic
AU  - Trama, Annalisa
AU  - Proto, Claudia
AU  - Whisenant, Jennifer G.
AU  - Torri, Valter
AU  - Cortellini, Alessio
AU  - Michielin, Olivier
AU  - Barlesi, Fabrice
AU  - Dingemans, Anne-Marie C.
AU  - Van Meerbeeck, Jan
AU  - Pancaldi, Vera
AU  - Mazieres, Julien
AU  - Soo, Ross A.
AU  - Leighl, Natasha B.
AU  - Peters, Solange
AU  - Wakelee, Heather
AU  - Horn, Leora
AU  - Hellmann, Matthew
AU  - Wong, Selina K.
AU  - Garassino, Marina Chiara
AU  - Baena, Javier
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Supporting Clinical Decision-Making, during the SARS-CoV-f2 Pandemic through a Global Research Commitment: The TERAVOLT Experience
T2  - Cancer Cell
TI  - Supporting Clinical Decision-Making, during the SARS-CoV-f2 Pandemic through a Global Research Commitment: The TERAVOLT Experience
UR  - https://doi.org/10.1016/j.ccell.2020.10.002
ID  - 7793215
ER  - 

TY  - JOUR
AB  - Serological detection of antibodies to SARS-CoV-2 is essential for establishing rates of seroconversion in populations, detection of seroconversion after vaccination, and for seeking evidence for a level of antibody that may be protective against COVID-19 disease. Several high-performance commercial tests have been described, but these require centralised laboratory facilities that are comparatively expensive, and therefore not available universally. Red cell agglutination tests have a long history in blood typing, and general serology through linkage of reporter molecules to the red cell surface. They do not require special equipment, are read by eye, have short development times, low cost and can be applied as a Point of Care Test (POCT). We describe a red cell agglutination test for the detection of antibodies to the SARS-CoV-2 receptor binding domain (RBD). We show that the Haemagglutination Test (HAT) has a sensitivity of 90% and specificity of 99% for detection of antibodies after a PCR diagnosed infection. The HAT can be titrated, detects rising titres in the first five days of hospital admission, correlates well with a commercial test that detects antibodies to the RBD, and can be applied as a point of care test. The developing reagent is composed of a previously described nanobody to a conserved glycophorin A epitope on red cells, linked to the RBD from SARS-CoV-2. It can be lyophilised for ease of shipping. We have scaled up production of this reagent to one gram, which is sufficient for ten million tests, at a cost of ~0.27 UK pence per test well. Aliquots of this reagent are ready to be supplied to qualified groups anywhere in the world that need to detect antibodies to SARS-CoV-2, but do not have the facilities for high throughput commercial tests.Competing Interest StatementThe authors have declared no competing interest.Funding StatementAT is funded by the Medical Research Council (MR/P021336/1), Townsend-Jeantet Charitable Trust (charity number 1011770) and the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant no. 2018-I2M-2-002). NG is funded by the Science Engineering Research Board, Department of Science and Technology, India. PCM is funded by the Wellcome Trust (grant ref 110110Z/15/Z). DR is supported by NIHR Oxford Biomedical Research Centre. National Institute for Health Research Biomedical Research Centre Funding Scheme (to G.R.S.), the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Science (CIFMS), China (grant number: 2018-I2M-2-002). G.R.S. is supported as a Wellcome Trust Senior Investigator (grant 095541/A/11/Z).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Oxfordshire Clinical Research Ethics Committee 08/H0606/107+5,NHS Blood and Transplant (NHSBT), ethics approval (NHSBT; RECOVERY [Cambridge East REC (ref: 20/EE/0101)] and REMAP-CAP [EudraCT 2015-002340-14],Sheffield REC, reference: 16/YH/0247]ISARIC/WHO, Clinical Characterisation Protocol for Severe Emerging Infections [Oxford REC C, reference 13/SC/0149], the Sepsis Immunomics project [Oxford REC C, reference:19/SC/0296]) and by the Scotland A Research Ethics Committee (Ref: 20/SS/0028,COVID-19 project New Delhi&#039;IPA/2020/000077&#039; Institutional Human Ethics Committee; Ref. no. - IHEC#128/20All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the stu y was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll the data and reagents are available on request.
AU  - Townsend, Alain
AU  - Rijal, Pramila
AU  - Xiao, Julie
AU  - Tan, Tiong Kit
AU  - Huang, Kuan-Ying A.
AU  - Schimanski, Lisa
AU  - Ho, Jiangdong
AU  - Gupta, Nimesh
AU  - Rahikainen, Rolle
AU  - Matthews, Philippa C.
AU  - Crook, Derrick
AU  - Hoosdally, Sarah
AU  - Street, Teresa
AU  - Rudkin, Justine
AU  - Stoesser, Nicole
AU  - Karpe, Fredrik
AU  - Neville, Matthew
AU  - Ploeg, Rutger
AU  - Oliveira, Marta
AU  - Roberts, David J.
AU  - Lamikanra, Abigail A.
AU  - Tsang, Hoi Pat
AU  - Bown, Abbie
AU  - Vipond, Richard
AU  - Mentzer, Alexander J.
AU  - Knight, Julian C.
AU  - Kwok, Andrew
AU  - Screaton, Gavin
AU  - Mongkolsapaya, Juthathip
AU  - Dejnirattisai, Wanwisa
AU  - Supasa, Piyada
AU  - Klenerman, Paul
AU  - Dold, Christina
AU  - Baillie, Kenneth
AU  - Moore, Shona C.
AU  - Openshaw, Peter J. M.
AU  - Semple, Malcolm G.
AU  - Turtle, Lance C. W.
AU  - Ainsworth, Mark
AU  - Allcock, Alice
AU  - Beer, Sally
AU  - Bibi, Sagida
AU  - Clutterbuck, Elixabeth
AU  - Espinosa, Alexis
AU  - Mendoza, Maria
AU  - Georgiou, Dominique
AU  - Lockett, Teresa
AU  - Martinez, Jose
AU  - Perez, Elena
AU  - Sanchez, Veronica
AU  - Scozzafava, Giuseppe
AU  - Sobrinodiaz, Alberto
AU  - Thraves, Hannah
AU  - Joly, Etienne
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205831
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205831
ST  - A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (preprint)
T2  - medRxiv
TI  - A haemagglutination test for rapid detection of antibodies to SARS-CoV-2 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.02.20205831.abstract
ID  - 7794773
ER  - 

TY  - JOUR
AB  - We aimed to determine the characteristics of coronavirus disease-2019 among the Iranian population In this study, we collected and analyzed the demographics, laboratory findings and outcomes of patients with COVID-19 who were admitted to Masih Daneshvari Hospital in Tehran, Iran between February 20, 2020 and April 2, 2020 Of 1061 patients, the median age was 55 years (interquartile range [IQR], 44-66 years) and 692 (65 2%) were male Among these, 129 (12 2%) patients died at some point during hospitalization in the ward or intensive care unit (ICU) From the remaining 932 survivors, 46 (5 0%) patients were admitted to the ICU and 886 (95 0%) patients were hospitalized in the ward Patients who died were significantly older than those hospitalized in the ward (p&amp;lt;0 001) The median absolute number of lymphocytes was 1 2 × 103 per microliter (IQR, 0 9-1 6 × 103 per microliter) and 708 (66 7%) patients had lymphopenia (absolute lymphocyte count &amp;lt;1500 per microliter) Among the laboratory tests, D-dimer, serum ferritin and albumin had the strongest correlation with mortality (r = 0 455, r = 0 412, r = -0 406, respectively;p-values &amp;lt;0 001) Conclusively, laboratory findings could provide useful information in regard to the management of patients with COVID-19
AU  - Toutkaboni, Mihan Pourabdollah
AU  - Askari, Elham
AU  - Khalili, Nastaran
AU  - Tabarsi, Payam
AU  - Jamaati, Hamidreza
AU  - Velayati, Ali Akbar
AU  - Dorudinia, Atosa
AU  - Rezaei, Mitrasadat
AU  - Nadji, Seyed Alireza
AU  - Mohamadnia, Abdolreza
AU  - Khalili, Neda
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Demographics, laboratory parameters and outcomes of 1061 patients with COVID-19: A report from Tehran, Iran
T2  - New Microbes and New Infections
TI  - Demographics, laboratory parameters and outcomes of 1061 patients with COVID-19: A report from Tehran, Iran
UR  - https://doi.org/10.1016/j.nmni.2020.100777
ID  - 7793085
ER  - 

TY  - JOUR
AB  - Summary The COVID-19 pandemic is an ongoing global challenge for public health systems Ultrasensitive and early identification of infection is critical to prevent widespread COVID-19 infection by presymptomatic and asymptomatic individuals, especially in the community and in-home settings We demonstrate a multiplexed, portable, wireless electrochemical platform for ultra-rapid detection of COVID-19: the SARS-CoV-2 RapidPlex It detects viral antigen nucleocapsid protein, IgM and IgG antibodies, as well as the inflammatory biomarker C-reactive protein, based on our mass-producible laser-engraved graphene electrodes We demonstrate ultrasensitive, highly selective, and rapid electrochemical detection in the physiologically relevant ranges We successfully evaluated the applicability of our SARS-CoV-2 RapidPlex platform with COVID-19 positive and negative blood and saliva samples Based on this pilot study, our multiplexed immunosensor platform may allow for high frequency at-home testing for COVID-19 telemedicine diagnosis and monitoring
AU  - Torrente-Rodr�Tguez, Rebeca M.
AU  - Lukas, Heather
AU  - Tu, Jiaobing
AU  - Min, Jihong
AU  - Yang, Yiran
AU  - Xu, Changhao
AU  - Rossiter, Harry B.
AU  - Gao, Wei
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - SARS-CoV-2 RapidPlex: A Graphene-based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring
T2  - Matter
TI  - SARS-CoV-2 RapidPlex: A Graphene-based Multiplexed Telemedicine Platform for Rapid and Low-Cost COVID-19 Diagnosis and Monitoring
UR  - https://doi.org/10.1016/j.matt.2020.09.027
ID  - 7793105
ER  - 

TY  - JOUR
AB  - Many employees unexpectedly were required to work from home during the COVID-19 pandemic of 2020 With this abrupt change came the challenge of blurred lines between career and personal life Lacking designated home office spaces, countless individuals had to create improvised work setups in living rooms, kitchens, bedrooms—wherever there was space Moreover, the closure of schools forced many working parents to attempt productivity while concurrently supervising their children As a result of these changes, numerous employees have experienced lower work productivity, lessened motivation, increased stress, and poorer mental health One approach that may help employees going through the challenges associated with working from home is mindfulness Mindfulness may be particularly beneficial as it can (1) help employees mentally disconnect from work when they need to;(2) improve individuals�?attention to work tasks and thereby improve their performance;and (3) allow workers to better manage screen fatigue In this installment of Work/Life Balance, we elaborate on how mindfulness may help employees deal with these work issues, explain how mindfulness can be cultivated, and provide a list of mindfulness techniques We also provide a set of recommendations for managers and team leaders responsible for their employees�?well-being and productivity
AU  - Toniolo-Barrios, Mariana
AU  - Pitt, Leyland
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Mindfulness and the challenges of working from home in times of crisis
T2  - Business Horizons
TI  - Mindfulness and the challenges of working from home in times of crisis
UR  - https://doi.org/10.1016/j.bushor.2020.09.004
ID  - 7793218
ER  - 

TY  - JOUR
AB  - The coronavirus crisis has damaged the U S economy This paper uses the stock returns of 125 sectors to investigate its impact It decomposes returns into components driven by sector-specific factors and by macroeconomic factors Idiosyncratic factors harmed industries such as airlines, aerospace, real estate, tourism, oil, brewers, retail apparel, and funerals There are thus large swaths of the economy whose recovery depends not on the macroeconomic environment but on controlling the pandemic Macroeconomic factors generated losses in industries such as production equipment, machinery, and electronic and electrical equipment Thus, reviving capital goods spending requires not just an end to the pandemic but also a macroeconomic recovery
AU  - Thorbecke, Willem
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Impact of the COVID-19 Pandemic on the U.S. Economy: Evidence from the Stock Market
T2  - Journal of Risk and Financial Management
TI  - The Impact of the COVID-19 Pandemic on the U.S. Economy: Evidence from the Stock Market
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813272
ID  - 7793330
ER  - 

TY  - JOUR
AB  - Introduction No studies have reported mental health symptom comparisons prior to and during COVID-19 in vulnerable medical populations Objective To compare anxiety and depression symptoms among people with a pre-existing medical condition and factors associated with changes Methods Pre-COVID-19 Scleroderma Patient-centered Intervention Network Cohort data were linked to COVID-19 data from April 2020 Multiple linear and logistic regression were used to assess factors associated with continuous change and ≥�? minimal clinically important difference (MCID) change for anxiety (PROMIS Anxiety 4a v1 0;MCID�?�? 0) and depression (Patient Health Questionnaire-8;MCID�?�? 0) symptoms, controlling for pre-COVID-19 levels Results Mean anxiety symptoms increased 4 9 points (95% confidence interval [CI] 4 0 to 5 7) Depression symptom change was negligible (0 3 points;95% CI -0 7 to 0 2) Compared to France (N�?�?59), adjusted anxiety symptom change scores were significantly higher in the United Kingdom (N�?�?0;3 3 points, 95% CI 0 9 to 5 6), United States (N�?�?28;2 5 points, 95% CI 0 7 to 4 2), and Canada (N�?�?8;1 9 points, 95% CI 0 1 to 3 8) Odds of �? MCID increase were 2 6 for the United Kingdom (95% CI 1 2 to 5 7) but not significant for the United States (1 6, 95% CI 0 9 to 2 9) or Canada (1 4, 95% CI 0 7 to 2 5) Older age and adequate financial resources were associated with less continuous anxiety increase Employment and shorter time since diagnosis were associated with lower odds of a ≥�? MCID increase Conclusions Anxiety symptoms, but not depression symptoms, increased dramatically during COVID-19 among people with a pre-existing medical condition
AU  - Thombs, Brett D.
AU  - Kwakkenbos, Linda
AU  - Henry, Richard S.
AU  - Carrier, Marie-Eve
AU  - Patten, Scott
AU  - Harb, Sami
AU  - Bourgeault, Angelica
AU  - Tao, Lydia
AU  - Bartlett, Susan J.
AU  - Mouthon, Luc
AU  - Varga, John
AU  - Benedetti, Andrea
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A scleroderma patient-centered intervention network (SPIN) cohort study
T2  - Journal of Psychosomatic Research
TI  - Changes in mental health symptoms from pre-COVID-19 to COVID-19 among participants with systemic sclerosis from four countries: A scleroderma patient-centered intervention network (SPIN) cohort study
UR  - https://doi.org/10.1016/j.jpsychores.2020.110262
ID  - 7793119
ER  - 

TY  - JOUR
AB  - Heterogeneous Fenton catalysts are emerging as excellent systems for applications related to water purification In this review, recent trends in the synthesis and application of heterogeneous Fenton catalysts for the abatement of organic pollutants and disinfection of microorganisms are discussed It is noted that as the complexity of cell wall increases, the resistance level towards various disinfectants increases and it requires either harsh conditions or longer exposure time for the complete disinfection In case of viruses, enveloped viruses (e g SARS-CoV-2) are found to be more susceptible to disinfectants than the non-enveloped viruses The introduction of plasmonic systems with the Fenton catalysts broaden the visible light absorption efficiency of the hybrid material, and incorporation of semiconductor material improves the rate of regeneration of Fe(II) from Fe(III) A special emphasis is given to the use of Fenton catalysts for antibacterial applications Composite materials of magnetite and ferrites remain a champion in this area because of their easy separation and reuse, owing to their magnetic properties Iron minerals supported on clay materials, perovskites, carbon materials, zeolites and metal-organic frameworks (MOFs) dramatically increase the catalytic degradation rate of contaminants by providing high surface area, good mechanical stability, and improved electron transfer Moreover, insights to the zero-valent iron and its capacity to remove a wide range of organic pollutants, heavy metals and bacterial contamination are also discussed Real world applications and the role of natural organic matter are summarised Parameter optimisation (e g light source, dosage of catalyst, concentration of H2O2 etc ), sustainable models for the reusability or recyclability of the catalyst and the theoretical understanding and mechanistic aspects of the photo-Fenton process are also explained Additionally, this review summarises the opportunities and future directions of research in the heterogeneous Fenton catalysis
AU  - Thomas, Nishanth
AU  - Dionysiou, Dionysios D.
AU  - Pillai, Suresh C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Heterogeneous Fenton Catalysts: A Review of Recent Advances
T2  - Journal of Hazardous Materials
TI  - Heterogeneous Fenton Catalysts: A Review of Recent Advances
UR  - https://doi.org/10.1016/j.jhazmat.2020.124082
ID  - 7793131
ER  - 

TY  - JOUR
AB  - The idea of a global orthodontic organization, the World Federation of Orthodontists (WFO), made up of national and regional orthodontic organizations, was realized in 1995 in San Francisco at the 4th International Orthodontic Congress that was held in conjunction with the 95th annual American Association of Orthodontists meeting. This umbrella organization strives to promote quality orthodontic care, practiced and delivered by orthodontic specialists in all parts of the world. In addition, it supports its member organizations with governing principles that promote appropriate membership criteria, qualified individual leadership participation, and long-term stability of the organization over time. In response to the Coronavirus Disease 2019 pandemic, the WFO has responded proactively and plans to augment its digital resources even further in the near future. This article describes the formation of the organization, the idea that germinated through the first three international orthodontic congresses, its workflow and membership criteria, the accountability and commitment it has toward its affiliates and individual members, and its plans for future years to come.
AD  - President, World Federation of Orthodontists, St. Louis, MO.
Secretary General, World Federation of Orthodontists, St. Louis, MO.
Vice-President, World Federation of Orthodontists, St. Louis, MO.
President Elect, World Federation of Orthodontists, St. Louis, MO. Electronic address: orthonik@gmail.com.
AN  - 33023729
AU  - Thom, A. R.
AU  - Graber, L. W.
AU  - Maplethorp, F. A.
AU  - Vaid, N. R.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.ejwf.2020.09.005
DP  - NLM
ET  - 2020/10/08
IS  - 3s
J2  - Journal of the World federation of orthodontists
KW  - Global organization
International Orthodontic Congress
WFO membership
World Federation of Orthodontists
World Orthodontic Health Day
LA  - eng
N1  - 2212-4438
Thom, Allan R
Graber, Lee W
Maplethorp, F Amanda
Vaid, Nikhilesh R
Journal Article
United States
J World Fed Orthod. 2020 Oct;9(3S):S3-S14. doi: 10.1016/j.ejwf.2020.09.005.
PY  - 2020
SN  - 2212-4438
SP  - S3-s14
ST  - World Federation of Orthodontists: An orthodontic umbrella organization coordinating activities and pooling resources
T2  - Journal of World federation of orthodontists
TI  - World Federation of Orthodontists: An orthodontic umbrella organization coordinating activities and pooling resources
VL  - 9
ID  - 7790883
ER  - 

TY  - JOUR
AB  - COVID-19 derives from infection with Coronavirus [severe acute respiratory syndrome (SARS)-CoV-2] and is associated with high morbidity and mortality due to release of a storm of pro-inflammatory cytokines and thrombogenic agents resulting in destruction of the lungs. Many reports indicate that a considerable number of patients who are positive for SARS-CoV-2 are asymptomatic or have mild symptoms. However, increasing evidence suggests that many such patients who either recovered from or had mild symptoms after COVID-19 exhibit diffuse, multiorgan, symptoms months after the infection. These symptoms include malaise, myalgias, chest tightness, brain fog and other neuropsychiatric symptoms that were originally reported in children and named Multisystem Inflammatory Syndrome (MIS-C). Now the US Center for Disease Control (CDC) announced the recognition of a similar condition in adults, named Multisystem Inflammatory Syndrome (MIS-A). The symptoms characterizing these conditions are very similar to those associated with Mast Cell Activation Syndrome (MCAS, US ICD-110 code D89.42-idiopathic mast cell activation syndrome). Hence, the possibility of MCAS should be evaluated in any patient with MIS and/or multisystem inflammatory symptoms. In either case, these syndromes should be addressed with liposomal formulation (in olive pomace oil) of the flavone luteolin (e.g. PureLut�] or FibroProtek�]) together with the antihistamine rupatadine, which also has anti-platelet activating factor (PAF) activity and inhibits mast cells that have been implicated in the pathogenesis of cytokine storms in COVID-19.
AD  - Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston. MA 02111, USA.
School of Graduate Biomedical Sciences, Tufts University School of Medicine, Boston, MA 02111, USA.
Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, MA 02111, USA.
Postgraduate Medical School, University of Chieti, Chieti 66013, Italy.
AN  - 33023287
AU  - Theoharides, T. C.
AU  - Conti, P.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.23812/20-edit3
DP  - NLM
ET  - 2020/10/08
IS  - 5
J2  - Journal of biological regulators and homeostatic agents
KW  - Covid-19
Mis-a
Mis-c
Multisystem Inflammatory Syndrome
SARS-CoV-2
cytokine storm
immunity
inflammation
mast-cell
LA  - eng
N1  - Theoharides, T C
Conti, P
Editorial
Italy
J Biol Regul Homeost Agents. 2020 Oct 5;34(5). doi: 10.23812/20-EDIT3.
PY  - 2020
SN  - 0393-974X (Print)
0393-974x
ST  - COVID-19 and Multisystem Inflammatory Syndrome, or is it mast cell activation syndrome?
T2  - Journal of biological regulators and homeostatic agents
TI  - COVID-19 and Multisystem Inflammatory Syndrome, or is it mast cell activation syndrome?
VL  - 34
ID  - 7790922
ER  - 

TY  - JOUR
AN  - 33022645
AU  - Tempero, M.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.6004/jnccn.2020.0049
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Journal of the National Comprehensive Cancer Network : JNCCN
LA  - eng
N1  - 1540-1413
Tempero, Margaret
Journal Article
United States
J Natl Compr Canc Netw. 2020 Oct 1;18(10):1291. doi: 10.6004/jnccn.2020.0049.
PY  - 2020
SN  - 1540-1405
SP  - 1291
ST  - Flirting With Disaster: COVID-19 and Cancer
T2  - Journal of National Comprehensive Cancer Network : JNCCN
TI  - Flirting With Disaster: COVID-19 and Cancer
VL  - 18
ID  - 7790953
ER  - 

TY  - JOUR
AB  - Introduction Laparoscopic cholecystectomy has become the gold standard for gallbladder disease Although gallbladder perforation and spilled gallstones during surgery are common complications, thoracic consequences are rare Presentation of case We describe a case of a pleural empyema developed in an immunosuppressed patient five months after laparoscopic cholecystectomy, as a result of spilled gallstones Decortication via video assisted thoracoscopy resulted in retrieval of stone remnants, biliary sludge and diagnosis of a diaphragmatic defect Discussion Iatrogenic perforation of the gallbladder is the most common complication after laparoscopic cholecystectomy Despite this, thoracic consequences derived from spilled gallstones are rare, but they represent significant morbidity Conclusion Thoracic complications after spilled gallstones are rare Documentation of iatrogenic perforation of the gallbladder and a high index of suspicious are fundamental to speed diagnosis and treatment
AU  - Tchercansky, Ariel Nicolas
AU  - Fernandez Alberti, Joaquin
AU  - Panzardi, Nicolas
AU  - Auvieux, Rodolfo
AU  - Buero, Agustin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Thoracic empyema after gallstone spillage in times of Covid
T2  - International Journal of Surgery Case Reports
TI  - Thoracic empyema after gallstone spillage in times of Covid
UR  - https://doi.org/10.1016/j.ijscr.2020.09.181
ID  - 7793158
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is accountable for the cause of coronavirus disease (COVID-19) that causes a major threat to humanity. As the spread of the virus is probably getting out of control on every day, the epidemic is now crossing the most dreadful phase. Idiopathic pulmonary fibrosis (IPF) is a risk factor for COVID-19 as patients with long-term lung injuries are more likely to suffer in the severity of the infection. Transcriptomic analyses of SARS-CoV-2 infection and IPF patients in lung epithelium cell datasets were selected to identify the synergistic effect of SARS-CoV-2 to IPF patients. Common genes were identified to find shared pathways and drug targets for IPF patients with COVID-19 infections. Using several enterprising Bioinformatics tools, protein-protein interactions (PPIs) network was designed. Hub genes and essential modules were detected based on the PPIs network. TF-genes and miRNA interaction with common differentially expressed genes and the activity of TFs are also identified. Functional analysis was performed using gene ontology terms and Kyoto Encyclopedia of Genes and Genomes pathway and found some shared associations that may cause the increased mortality of IPF patients for the SARS-CoV-2 infections. Drug molecules for the IPF were also suggested for the SARS-CoV-2 infections.
AD  - Department of Software Engineering, Daffodil International University.
Information and Communication Technology (ICT) at Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Department of Information and Communication Technology (ICT) at Mawlana Bhashani Science and Technology University, Tangail, Bangladesh.
Department of Information and Communication Technology, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh.
Shenyang University of Chemical Technology, China.
University of New South Wales, Australia.
AN  - 33024988
AU  - Taz, T. A.
AU  - Ahmed, K.
AU  - Paul, B. K.
AU  - Kawsar, M.
AU  - Aktar, N.
AU  - Mahmud, S. M. H.
AU  - Moni, M. A.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1093/bib/bbaa235
DP  - NLM
ET  - 2020/10/08
J2  - Briefings in bioinformatics
KW  - SARS-CoV-2
differentially expressed genes
drug molecule
gene ontology
hub gene
idiopathic pulmonary fibrosis
protein–protein interactions
LA  - eng
N1  - 1477-4054
Taz, Tasnimul Alam
Ahmed, Kawsar
Paul, Bikash Kumar
Kawsar, Md
Aktar, Nargis
Mahmud, S M Hasan
Moni, Mohammad Ali
Journal Article
England
Brief Bioinform. 2020 Oct 7:bbaa235. doi: 10.1093/bib/bbaa235.
PY  - 2020
SN  - 1467-5463
ST  - Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients
T2  - Briefings in bioinformatics
TI  - Network-based identification genetic effect of SARS-CoV-2 infections to Idiopathic pulmonary fibrosis (IPF) patients
ID  - 7790728
ER  - 

TY  - JOUR
AB  - COVID-19, caused by SARS-CoV-2, has resulted in a global pandemic recently. With no approved vaccination or treatment, governments around the world have issued guidance to their citizens to remain at home in efforts to control the spread of the disease. The goal of controlling the spread of the virus is to prevent strain on hospitals. In this paper, we focus on how non-invasive methods are being used to detect COVID-19 and assist healthcare workers in caring for COVID-19 patients. Early detection of COVID-19 can allow for early isolation to prevent further spread. This study outlines the advantages and disadvantages and a breakdown of the methods applied in the current state-of-the-art approaches. In addition, the paper highlights some future research directions, which need to be explored further to produce innovative technologies to control this pandemic.
AD  - James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, UK.
Centre for Intelligent Healthcare, Coventry University, Coventry CV1 5RW, UK.
AN  - 33023039
AU  - Taylor, W.
AU  - Abbasi, Q. H.
AU  - Dashtipour, K.
AU  - Ansari, S.
AU  - Shah, S. A.
AU  - Khalid, A.
AU  - Imran, M. A.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/s20195665
DP  - NLM
ET  - 2020/10/08
IS  - 19
J2  - Sensors (Basel, Switzerland)
KW  - Ai
Covid-19
Ml
Sars-Cov-2
disease diagnostics
population health
sensing
LA  - eng
N1  - 1424-8220
Taylor, William
Abbasi, Qammer H
Orcid: 0000-0002-7097-9969
Dashtipour, Kia
Orcid: 0000-0002-9651-6487
Ansari, Shuja
Shah, Syed Aziz
Khalid, Arslan
Imran, Muhammad Ali
Orcid: 0000-0003-4743-9136
EPSRC DTG EP/N509668/1 Eng/CENSIS UK/
EP/T021020/1/Scottish Funding Council/
EP/T021063/1/British Telecommunications/
Journal Article
Review
Switzerland
Sensors (Basel). 2020 Oct 3;20(19):E5665. doi: 10.3390/s20195665.
PY  - 2020
SN  - 1424-8220
ST  - A Review of the State of the Art in Non-Contact Sensing for COVID-19
T2  - Sensors (Basel, Switzerland)
TI  - A Review of the State of the Art in Non-Contact Sensing for COVID-19
VL  - 20
ID  - 7790929
ER  - 

TY  - JOUR
AB  - Colloquially known as coronavirus, the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2), that causes CoronaVirus Disease 2019 (COVID-19), has become a matter of grave concern for every country around the world The rapid growth of the pandemic has wreaked havoc and prompted the need for immediate reactions to curb the effects To manage the problems, many research in a variety of area of science have started studying the issue Artificial Intelligence is among the area of science that has found great applications in tackling the problem in many aspects Here, we perform an overview on the applications of AI in a variety of fields including diagnosis of the disease via different types of tests and symptoms, monitoring patients, identifying severity of a patient, processing covid-19 related imaging tests, epidemiology, pharmaceutical studies, etc The aim of this paper is to perform a comprehensive survey on the applications of AI in battling against the difficulties the outbreak has caused Thus we cover every way that AI approaches have been employed and to cover all the research until the writing of this paper We try organize the works in a way that overall picture is comprehensible Such a picture, although full of details, is very helpful in understand where AI sits in current pandemonium We also tried to conclude the paper with ideas on how the problems can be tackled in a better way and provide some suggestions for future works
AU  - Tayarani-N, Mohammad- H.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Applications of Artificial Intelligence in Battling Against Covid-19: A Literature Review
T2  - Chaos, Solitons & Fractals
TI  - Applications of Artificial Intelligence in Battling Against Covid-19: A Literature Review
UR  - https://doi.org/10.1016/j.chaos.2020.110338
ID  - 7793212
ER  - 

TY  - JOUR
AB  - At the end of 2019, a new kind of pneumonia which was proven to be supported by novel coronaviruses named SARS-CoV-2 emerges and it seems to be more complicate in its clinical course and management. Related researches have demonstrated that SARS-CoV-2 serves roles in respiratory, intestinal and neuronal diseases. Given the growing cases of COVID-19, analyzing the relevance between COVID-19 and fragile patients who suffer from bone destruction is entirely indispensable. Accordingly, the recapitulatory commentary is necessary to advance our knowledge on COVID-19 and orthopedics. In this article, we particularly clarify the possible relationship between the newly COVID-19 infection and bone lesions from the standpoints of dysimmunity and inflammatory storm.
AN  - PMC7536122
AU  - Tao, Huaqiang
AU  - Ge, Gaoran
AU  - Li, Wenming
AU  - Liang, Xiaolong
AU  - Wang, Hongzhi
AU  - Li, Ning
AU  - Sun, Houyi
AU  - Zhang, Wei
AU  - Geng, Dechun
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.mehy.2020.110332
DP  - NLM
J2  - Med Hypotheses
KW  - COVID-19
SARS-CoV-2
dysimmunity
inflammatory storm
bone lesions
LA  - eng
N1  - PMC7536122[pmcid]
S0306-9877(20)32973-X[PII]
PY  - 2020
SN  - 0306-9877
1532-2777
SP  - 110332
ST  - Dysimmunity and inflammatory storm: Watch out for bone lesions in COVID-19 infection
T2  - Medical Hypotheses
TI  - Dysimmunity and inflammatory storm: Watch out for bone lesions in COVID-19 infection
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536122/
ID  - 7790672
ER  - 

TY  - JOUR
AD  - New York, USA.
AN  - 33023878
AU  - Tanne, J. H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/bmj.m3897
DP  - NLM
ET  - 2020/10/08
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Tanne, Janice Hopkins
Journal Article
England
BMJ. 2020 Oct 6;371:m3897. doi: 10.1136/bmj.m3897.
PY  - 2020
SN  - 0959-8138
SP  - m3897
ST  - Covid-19: Trump returns to White House amid confusion over his illness and treatment
T2  - BMJ
TI  - Covid-19: Trump returns to White House amid confusion over his illness and treatment
VL  - 371
ID  - 7790869
ER  - 

TY  - JOUR
AB  - Introduction The data of immunosuppressive therapy management on solid organ transplant recipients with coronavirus disease 2019 are insufficient We report a kidney transplant recipient who developed coronavirus disease 2019 pneumonia, with successful management of low-dose mPSL Case presentation A 36-year-old man, who underwent living kidney transplantation 1 5 year prior, developed fever After 10 days, he developed dyspnea, and his blood oxygen levels decreased Computed tomography showed pulmonary ground-glass shadow on both lungs, and the coronavirus disease 2019 real-time polymerase chain reaction test was positive After reducing the immunosuppressive agents, the C-reactive protein levels continued elevating, and the pulmonary shadow spread Subsequently, low-dose methylprednisolone (40 mg/day) was administered for 4 days and his C-reactive protein and blood oxygen levels increased and improved, respectively The coronavirus disease 2019 real-time polymerase chain reaction test was negative and the pulmonary shadow disappeared Conclusion Low-dose methylprednisolone may prevent the development of severe coronavirus disease 2019
AU  - Tanaka, Ryo
AU  - Kakuta, Yoichi
AU  - Tsutahara, Koichi
AU  - Nakagawa, Masahiro
AU  - Ichimaru, Naotsugu
AU  - Sakaguchi, Katsuhiko
AU  - Kato, Taigo
AU  - Imamura, Ryoichi
AU  - Nonomura, Norio
AU  - Takao, Tetsuya
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low-dose methylprednisolon
T2  - IJU Case Reports
TI  - Successful recovery from coronavirus disease 2019 in a living kidney transplant recipient using low-dose methylprednisolon
UR  - https://doi.org/10.1002/iju5.12226
ID  - 7793311
ER  - 

TY  - JOUR
AD  - Yongtian Tina Tan, M.D., M.B.A., is is a third year pediatric resident at University of California San Francisco and a recent graduate of the Harvard M.D./M.B.A. program. Aaron S. Kesselheim, M.D., J.D., M.P.H., is Professor of Medicine at Harvard Medical School, a faculty member of the Division of Pharmacoepidemiology and Pharmacoeconomics in the Department of Medicine at Brigham and Women's Hospital, the Director of the Program on Regulation, Therapeutics, and Law (PORTAL), and a primary care physician. He is the Editor-in-Chief of the Journal of Law, Medicine & Ethics.
AN  - 33021179
AU  - Tan, Y. T.
AU  - Kesselheim, A. S.
C1  - 10/7/2020
DA  - Sep
DB  - PubMed
DO  - 10.1177/1073110520958889
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
LA  - eng
N1  - 1748-720x
Tan, Yongtian Tina
Kesselheim, Aaron S
Journal Article
United States
J Law Med Ethics. 2020 Sep;48(3):606-612. doi: 10.1177/1073110520958889.
PY  - 2020
SN  - 1073-1105
SP  - 606-612
ST  - Implementing U.S. Covid-19 Testing: Regulatory and Infrastructural Challenges
T2  - Journal of law, medicine & ethics : a journal of American Society of Law, Medicine & Ethics
TI  - Implementing U.S. Covid-19 Testing: Regulatory and Infrastructural Challenges
VL  - 48
ID  - 7791044
ER  - 

TY  - JOUR
AB  - ABSTRACT Objectives The strain on healthcare systems due to the COVID-19 pandemic has led to increased psychological distress among healthcare workers (HCWs) As this global crisis continues with little signs of abatement, we examine burnout and associated factors among HCWs Design Cross-sectional survey study Setting and Participants Doctors, nurses, allied health professionals, administrative and support staff in four public hospitals and one primary care service in Singapore 3 months after COVID-19 was declared a global pandemic Methods Study questionnaire captured demographic and workplace environment information and comprised three validated instruments, namely the Oldenberg Burnout Inventory (OLBI), Safety Attitudes Questionnaire (SAQ), and Hospital Anxiety and Depression Scale (HADS) Multivariate mixed model regression analyses were employed to evaluate independent associations of mean OLBI-Disengagement and -Exhaustion scores Further subgroup analysis was performed among redeployed HCWs Results Among 11,286 invited HCWs, 3,075 valid responses were received, giving an overall response rate of 27 2% Mean OLBI scores were 2 38 and 2 50 for Disengagement and Exhaustion respectively Burnout thresholds in Disengagement and Exhaustion were met by 79 7% and 75 3% of respondents respectively On multivariate regression analysis, Chinese or Malay ethnicity, HADS anxiety or depression scores �?, shifts lasting �? hours and being redeployed were significantly associated with higher OLBI mean scores, while high SAQ scores were significantly associated with lower scores Among redeployed HCWs, those redeployed to high-risk areas in a different facility (offsite) had lower burnout scores than those redeployed within their own work facility (onsite) A higher proportion of HCWs redeployed offsite assessed their training to be good or better compared to those redeployed onsite Conclusions and Implications Every level of the healthcare workforce is susceptible to high levels of burnout during this pandemic Modifiable workplace factors include adequate training, avoiding prolonged shifts �? hours and promoting safe working environments Mitigating strategies should target every level of the healthcare workforce including frontline and non-frontline staff Addressing and ameliorating burnout among HCWs should be a key priority for the sustainment of efforts to care for patients in the face of a prolonged pandemic
AU  - Tan, Benjamin Y. Q.
AU  - Abhiram, Kanneganti
AU  - Lim, Lucas J. H.
AU  - Tan, Melanie
AU  - Chua, Ying Xian
AU  - Tan, Lifeng
AU  - Sia, Ching Hui
AU  - Denning, Max
AU  - Goh, Ee Teng
AU  - Purkayastha, Sanjay
AU  - Kinross, James
AU  - Sim, Kang
AU  - Chan, Yiong Huak
AU  - Ooi, Shirley
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Burnout and Associated Factors Amongst Healthcare Workers in Singapore during the COVID-19 pandemic
T2  - Journal of American Medical Directors Association
TI  - Burnout and Associated Factors Amongst Healthcare Workers in Singapore during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.jamda.2020.09.035
ID  - 7793142
ER  - 

TY  - JOUR
AB  - The human leukocyte antigen (HLA) is a complex genetic system that encodes proteins which predominantly regulate immune/inflammatory processes It can be involved in a variety of immuno-inflammatory disorders ranging from infections to autoimmunity and cancers The HLA system is also suggested to be involved in neurodevelopment and neuroplasticity, especially through microglia regulation and synaptic pruning Consequently, this highly polymorphic gene region has recently emerged as a major player in the etiology of several major psychiatric disorders, such as schizophrenia, autism spectrum disorder and bipolar disorder and with less evidence for major depressive disorders and attention deficit hyperactivity disorder We thus review here the role of HLA genes in particular subgroups of psychiatric disorders and foresee their potential implication in future research In particular, given the prominent role that the HLA system plays in the regulation of viral infection, this review is particularly timely in the context of the Covid-19 pandemic
AU  - Tamouza, Ryad
AU  - Krishnamoorthy, Rajagopal
AU  - Leboyer, Marion
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Understanding the genetic contribution of the Human Leukocyte Antigen system to common major psychiatric disorders in a world pandemic context
T2  - Brain, Behavior, and Immunity
TI  - Understanding the genetic contribution of the Human Leukocyte Antigen system to common major psychiatric disorders in a world pandemic context
UR  - https://doi.org/10.1016/j.bbi.2020.09.033
ID  - 7793226
ER  - 

TY  - JOUR
AB  - Chloroquine and hydroxychloroquine are commonly used drugs in the treatment of malaria as well as chronic diseases, such as rheumatoid arthritis, and systemic lupus erythematosus. Although various reports on possible psychiatric side effects of these drugs exist, the nature and extent of these effects remain poorly understood. Moreover, the relevance of these drugs in the treatment of early stages of COVID-19 necessitates a careful estimation of their side effects. Here, we provide a systematic review of the psychiatric side effects associated with chloroquine and hydroxychloroquine. We used PubMed, Scopus, and Web of Science platforms to identify relevant literature published between 1962 and 2020. Search terms included chloroquine, hydroxychloroquine, psychiatry, psychosis, depression, anxiety, bipolar disorder, delirium, and psychotic disorders. Only case reports and clinical trials were included. All studies included records of psychiatric side effects induced by either chloroquine or hydroxychloroquine or both. Both retrospective and prospective, randomized as well as non-randomized population studies were included. Overall, the psychiatric side effects are dose- and sex-independent. The most common psychiatric side effects reported are increased speech output/ excessive talking, increased psychomotor activity, irritable mood, auditory hallucinations, delusion of grandiosity, and suicide attempts, likely due to brain intoxicationbe of chloroquine or hydroxychloroquine. The symptoms can develop in a few hours to 11 weeks after drug intake and are normally reversed within a week after the drug withdrawal. We conclude that CQ and HCQ have the potential to induce psychiatric side effects. This study calls for further investigation of psychiatric symptoms induced by these drugs in the short and long term.Competing Interest StatementThe authors have declared no competing interest.Funding StatementDr. Cao was supported in part by the Canada Research Chairs program, NARSAD Young Investigator Grant of The Brain &amp;amp; Behavior Research Foundation. Both Dr. Cao and Talarico F are funded by the Alberta Synergies in Alzheimers and Related Disorders (SynAD) program. Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This is a systematic review manuscript, so no ethics is required.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll studies included in this review are cited in the manuscript. No additional data were used.
AU  - Talarico, Fernanda
AU  - Chakravarty, Sucheta
AU  - Liu, Yang
AU  - Greenshaw, Angrew
AU  - Passos, Ives
AU  - Cao, Bo
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20207423
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20207423
ST  - Psychiatric side effects induced by chloroquine and hydroxychloroquine: a systematic review of case reports and population studies (preprint)
T2  - medRxiv
TI  - Psychiatric side effects induced by chloroquine and hydroxychloroquine: a systematic review of case reports and population studies (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.05.20207423.abstract
ID  - 7794709
ER  - 

TY  - JOUR
AD  - Shizuoka Medical Center, Shizuoka, Japan kfgth973@ybb.ne.jp.
Mount Sinai Beth Israel Hospital, New York City, New York, USA.
Easton Hospital, Easton, Pennsylvania, USA.
Shizuoka Medical Center, Shizuoka, Japan.
New York Presbyterian Hospital/Columbia University Medical Center, New York City, New York, USA.
AN  - 33023971
AU  - Takagi, H.
AU  - Kuno, T.
AU  - Yokoyama, Y.
AU  - Ueyama, H.
AU  - Matsushiro, T.
AU  - Hari, Y.
AU  - Ando, T.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/jech-2020-214820
DP  - NLM
ET  - 2020/10/08
J2  - Journal of epidemiology and community health
KW  - Economics
Epidemiology
Ethnicity
Infection
Statistics
LA  - eng
N1  - 1470-2738
Takagi, Hisato
Orcid: 0000-0002-5594-8072
Kuno, Toshiki
Orcid: 0000-0002-2487-8366
Yokoyama, Yujiro
Ueyama, Hiroki
Matsushiro, Takuya
Hari, Yosuke
Ando, Tomo
Letter
England
J Epidemiol Community Health. 2020 Oct 6:jech-2020-214820. doi: 10.1136/jech-2020-214820.
PY  - 2020
SN  - 0143-005x
ST  - Ethnicity/race and economics in COVID-19: meta-regression of data from counties in the New York metropolitan area
T2  - Journal of epidemiology and community health
TI  - Ethnicity/race and economics in COVID-19: meta-regression of data from counties in the New York metropolitan area
ID  - 7790857
ER  - 

TY  - JOUR
AB  - Purpose With clinical volumes decreased, radiologists volunteered to participate virtually in daily clinical rounds and provide communication between front-line physicians and COVID-19 patient families affected by restrictive hospital visitation policies The purpose of this survey-based assessment was to demonstrate the beneficial effects of radiologist engagement during this pandemic, and potentially in future crises if needed Methods Following the program’s completion, a survey consisting of 13 multiple choice and open-ended questions was distributed to the 69 radiologists who volunteered for a minimum of 7 days The survey focused on how the experience would change future practice, the nature of interaction with medical students and the motivation for volunteering The electronic medical record system identified the positive or suspected COVID-19 patients and the number of notes documenting family communication Results Sixty-nine radiologists signed or cosigned 7,027 notes Sixty of 69 (87 0%) radiologists responded to the survey All found the experience increased their understanding of COVID-19 and its effect on the health care system Overall, 59 6% agreed that participation would result in future change in communication with patients and their families Nearly all (98 1%) who worked with medical students agreed that their experience with medical students was rewarding A majority (82 7%) chose to participate as a way to provide service to the patient population Conclusion This program provided support to front-line inpatient teams while also positively affecting the radiologist participants If a similar situation arises in the future, this communication tool could be redeployed, especially with the collaboration of medical students
AU  - Taffel, Myles T.
AU  - Hochman, Katherine A.
AU  - Chhor, Chloe M.
AU  - Alaia, Erin F.
AU  - Borja, Maria J.
AU  - Sondhi, Jaya
AU  - Lala, Shailee V.
AU  - Tong, Angela
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Impact on Participants of Family Connect, a Novel Program Linking COVID-19 Inpatients�?Families with the Frontline Providers
T2  - Journal of American College of Radiology
TI  - Impact on Participants of Family Connect, a Novel Program Linking COVID-19 Inpatients�?Families with the Frontline Providers
UR  - https://doi.org/10.1016/j.jacr.2020.08.019
ID  - 7793144
ER  - 

TY  - JOUR
AB  - ABSTRACT Purpose The decision to attempt closed treatment on tibial shaft fractures can be challenging At our institution, we attempt treatment of nearly all closed, isolated tibial shaft fractures The purpose of this study was to report the results of 10 years of experience to develop a tool to identify patients for whom non-operative treatment of tibial shaft fractures may be a viable option Method This was a retrospective review of patients with tibial shaft fracture seen at a level 1 trauma center over 10 years Patients with closed, isolated injuries underwent sedation, closed reduction, long-leg casting, and outpatient follow-up Patients were converted to surgery for inability to obtain or maintain acceptable alignment or patient intolerance Radiographic characteristics and patient demographics were extracted Logistic regression analysis was used to develop a model to predict which patient and injury characteristics determined success of nonoperative treatment Results 334 patients were identified with isolated, closed tibial shaft fractures, who were reduced and treated in a long leg cast 234 patients (70%) converted to surgical treatment due to inability to maintain alignment, patient intolerance, and nonunion In a regression model, coronal/sagittal translation, sagittal angulation, fracture morphology, and smoking status were shown to be significant predictors of success of nonoperative treatment (p &amp;lt; 0 05) We developed a Tibial Operative Outcome Likelihood (TOOL) score designed to help predict success or failure of closed treatment The TOOL score can be used to identify a subsegment of patients with injuries amenable to closed treatment (38% of injuries) with a nonoperative success rate over 60% Conclusion Non-operative treatment of tibial shaft fractures is feasible, although there is a relatively high conversion rate to operative treatment However, it is possible to use injury characteristics to identify a cohort of patients with a higher chance of success with closed treatment, which is potentially useful in a resource-constrained setting or for patients who wish to avoid surgery Level of Evidence Prognostic Level 3
AU  - Swart, Eric
AU  - Lasceski, Chad
AU  - Latario, Luke
AU  - Jo, Jacob
AU  - Nguyen, UyenSa
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Modern Treatment of Tibial Shaft Fractures: Is There a Role Today for Closed Treatment?: Short Title: Non-operative treatment of tibia fractures
T2  - Injury
TI  - Modern Treatment of Tibial Shaft Fractures: Is There a Role Today for Closed Treatment?: Short Title: Non-operative treatment of tibia fractures
UR  - https://doi.org/10.1016/j.injury.2020.10.018
ID  - 7793152
ER  - 

TY  - JOUR
AD  - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City.
Department of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City.
AN  - 33022069
AU  - Sullivan, C. B.
AU  - Schwalje, A. T.
AU  - Jensen, M.
AU  - Li, L.
AU  - Dlouhy, B. J.
AU  - Greenlee, J. D.
AU  - Walsh, J. E.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1001/jamaoto.2020.3579
DP  - NLM
ET  - 2020/10/07
J2  - JAMA otolaryngology-- head & neck surgery
LA  - eng
N1  - 2168-619x
Sullivan, Christopher Blake
Schwalje, Adam T
Jensen, Megan
Li, Luyuan
Dlouhy, Brian J
Greenlee, Jeremy D
Walsh, Jarrett E
Journal Article
United States
JAMA Otolaryngol Head Neck Surg. 2020 Oct 1. doi: 10.1001/jamaoto.2020.3579.
PY  - 2020
SN  - 2168-6181
ST  - Cerebrospinal Fluid Leak After Nasal Swab Testing for Coronavirus Disease 2019
T2  - JAMA otolaryngology-- head & neck surgery
TI  - Cerebrospinal Fluid Leak After Nasal Swab Testing for Coronavirus Disease 2019
ID  - 7790983
ER  - 

TY  - JOUR
AB  - Objective The COVID-19 pandemic has forced healthcare providers worldwide to bring in changes in the way cancer patients are cared for Many cancer departments globally have brought in changes to their daily practice This article is about our experience of evolving “COVID 19 PROTOCOL�?devised in our department and taking a shape to suit a health care system with limited budget Materials and methods All the patient census &amp; details of department of surgical oncology, Royapettah cancer hospital, from month of March 2020 to July 2020, who were subjected to COVID protocol were compared to patient census of similar duration in immediate past five months of October 2019 to February 2020 The data from out-patient department, ward in-patient census and healthcare personnel data was analyzed Results There was a drop to 63 5% in OP census and 61 6% in IP census There was a drop to 64 5% in number of major cases operated during initial phases of COVID pandemic Health care workers were also infected with the COVID but cross infectivity can be checked if proper steps to adhere to an institutional protocol based on general measures of cleanliness are taken Conclusion Adherence to an institutional protocol based on compliance to general measures of masking, hand washing and social distancing plays a major role in minimizing disease spread The Royapettah COVID protocol, though in process of evolution, can be recommended for any health care center with limited resources
AU  - Subbiah, Shanmugam
AU  - Hussain, Syed Afroze
AU  - Samanth Kumar, M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Managing cancer during COVID pandemic �?Experience of a tertiary cancer care center
T2  - European Journal of Surgical Oncology
TI  - Managing cancer during COVID pandemic �?Experience of a tertiary cancer care center
UR  - https://doi.org/10.1016/j.ejso.2020.09.027
ID  - 7793184
ER  - 

TY  - JOUR
AN  - 33024338
AU  - Subbaraman, N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/d41586-020-02819-y
DP  - NLM
ET  - 2020/10/08
J2  - Nature
KW  - Diseases
Health care
Infection
Politics
SARS-CoV-2
LA  - eng
N1  - 1476-4687
Subbaraman, Nidhi
News
England
Nature. 2020 Oct 6. doi: 10.1038/d41586-020-02819-y.
PY  - 2020
SN  - 0028-0836
ST  - Contact tracing Trump's travels would require 'massive' effort
T2  - Nature
TI  - Contact tracing Trump's travels would require 'massive' effort
ID  - 7790821
ER  - 

TY  - JOUR
AB  - Opioid use disorder (OUD) is one of the most pressing public health problems in the United States and is highly prevalent among adolescents and young adults (AYAs). However, only a small percentage of AYAs with OUD ever receive treatment. Further, among those that do receive treatment, a substantial proportion of patients continue to struggle with OUD and many prematurely drop out of treatment. These challenges have only been heightened in the face of the coronavirus disease 2019 pandemic, but greater utilization of telehealth and mobile technologies by OUD patients may help counter these barriers, which ultimately may improve AYA OUD treatment post-pandemic. This viewpoint presents the perspective of a person in OUD recovery using online and mobile technology to support his own OUD recovery combined with thoughts from two clinicians supporting AYAs with OUD; their perspectives may provide insights to help counter COVID-19 related consequences and offer clues to improving AYA OUD treatment long-term.
AD  - Department of Biobehavioral Health, The Pennsylvania State University, Biobehavioral Health Building, University Park, US.
Division of Adolescent Medicine, Nationwide Children's Hospital, Columbus, US.
Department of Pediatrics, The Ohio State University, Columbus, US.
Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, US.
AN  - 33016885
AU  - Stull, S. W.
AU  - McKnight, E. R.
AU  - Bonny, A. E.
C1  - 10/7/2020
DA  - Sep 25
DB  - PubMed
DO  - 10.2196/23463
DP  - NLM
ET  - 2020/10/06
J2  - JMIR pediatrics and parenting
LA  - eng
N1  - 2561-6722
Stull, Samuel W
McKnight, Erin R
Bonny, Andrea E
Journal Article
Canada
JMIR Pediatr Parent. 2020 Sep 25. doi: 10.2196/23463.
PY  - 2020
SN  - 2561-6722
ST  - Patient and Clinician Perspectives on Adolescent Opioid Use Disorder Treatment During a Pandemic: One step back, but two forward?
T2  - JMIR pediatrics and parenting
TI  - Patient and Clinician Perspectives on Adolescent Opioid Use Disorder Treatment During a Pandemic: One step back, but two forward?
ID  - 7791265
ER  - 

TY  - JOUR
AB  - Background Concurrent non-pharmaceutical interventions have been implemented around the world to control Covid-19 transmission. Their general effect on reducing virus transmission is proven, but they can also be negative to mental health and economies, and transmission behaviours can also change in absence of mandated policies. Their relative impact on Covid-19 attributed mortality rates, enabling policy selection for maximal benefit with minimal disruption, is not well established. Methods We exploited variations in nine non-pharmaceutical interventions implemented in 130 countries (3250 observations) in two periods chosen to limit reverse causality: i) prior to first Covid-19 death (when policymakers could not possibly be reacting to deaths in their own country); and, ii) 14-days-post first Covid-19 death (when deaths were still low, on average). We examined associations with daily deaths per million in each subsequent 24-day period (the time between virus transmission and mortality) which could only be affected by the policy period. A mean score of strictness and timeliness was coded for each intervention. Days in each country were indexed in time by first reported Covid-19 death to proxy for virus transmission rate. Multivariable linear regression models of Covid-19 mortality rates on all concurrent interventions were adjusted for seasonality, potential confounders, and potential cross-country differences in their mortality definitions. Robustness was checked by removing countries with known data reporting issues and with non-linear, negative binomial, models. Results After adjusting for multiple concurrent interventions and confounders, and accounting for both timing and strictness of interventions, earlier and stricter school (-1.23 daily deaths per million, 95% CI -2.20 -0.27) and workplace closures (-0.26, 95% CI -0.46 -0.05) were associated with lower Covid-19 mortality rates. Only controlling for strictness international travel controls, and only controlling for timing later restrictions on gatherings, were also associated with lower Covid-19 mortality. Other interventions, such as stay-at-home orders or restrictions on public transport, were not significantly associated with differences in mortality rates across countries. Findings were robust across multiple statistical approaches. Conclusions Focusing on compulsory, particularly school closing, not voluntary reduction of social interactions with mandated policies appears to have been the most effective strategy to mitigate early Covid-19 mortality.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe authors received no specific funding for this work. JS was supported by an MRC Fellowship.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Not applicableAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe datasets analysed during the current study are available from: -Policy data: https://covidtracker.bsg.ox.ac.uk/ -Covid-19 mortality data: https://www.ecdc.europa.eu/en/publications-data/downloadtodays-data-geographic-distribution-covid-19-cases-worldwide https://c vidtracker.bsg.ox.ac.uk/https://www.ecdc.europa.eu/en/publications-data/downloadtodays-data-geographic-distribution-covid-19-cases-worldwide
AU  - Stokes, Jonathan
AU  - Turner, Alex James
AU  - Anselmi, Laura
AU  - Morciano, Marcello
AU  - Hone, Thomas
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206888
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206888
ST  - The relative effects of non-pharmaceutical interventions on early Covid-19 mortality: natural experiment in 130 countries (preprint)
T2  - medRxiv
TI  - The relative effects of non-pharmaceutical interventions on early Covid-19 mortality: natural experiment in 130 countries (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206888.abstract
ID  - 7794758
ER  - 

TY  - JOUR
AB  - A hegemon can destroy its international regimes, but what happens when it does not possess the capacity to reconstitute a regime to its liking? Drawing on structural power theory, our article examines President Nixon’s historic attacks on the Bretton Woods international monetary regime to help illuminate President Trump’s attacks on the World Trade Organisation (WTO) In both cases regime destruction was driven to a large extent by a desire to contain rivals: Europe for Nixon, China for Trump Drawing on original archival material, our case study analysis shows that while the United States possessed sufficient negative structural power to derail Bretton Woods, it lacked sufficient positive structural power to create the new monetary structure Nixon wanted Trump faces a similar dilemma: he can block the WTO regime, but cannot necessarily replace it with one to the United States�?liking China is too powerful and possesses too much structural power of its own to give up its WTO privileges without a fight After the Coronavirus pandemic, it is unlikely that China can prevent the United States from wrecking the WTO trade regime, but very likely it can block US attempts to create a successor regime tailored exclusively to US requirements
AU  - Stokes, Doug
AU  - Williamson, Martin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The United States, China and the WTO after Coronavirus
T2  - Chinese Journal Of International Politics
TI  - The United States, China and the WTO after Coronavirus
UR  - https://doi.org/10.1093/cjip/poaa013
ID  - 7792924
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has resulted in an increased need for ventilators. The potential to ventilate more than one patient with a single ventilator, a so-called split ventilator setup, provides an emergency solution. Our hypothesis is that ventilation can be individualized by adding a flow restrictor to limit tidal volumes, add PEEP, titrate FiO(2) and monitor ventilation. This way we could enhance optimization of patient safety and clinical applicability. We performed bench testing to test our hypothesis and identify limitations. We performed a bench testing in two test lungs: (1) determine lung compliance (2) determine volume, plateau pressure and PEEP, (3) illustrate individualization of airway pressures and tidal volume with a flow restrictor, (4a) illustrate that PEEP can be applied and individualized (4b) create and measure intrinsic PEEP (4c and d) determine PEEP as a function of flow restriction, (5) individualization of FiO(2). The lung compliance varied between 13 and 27 mL/cmH(2)O. Set ventilator settings could be applied and measured. Extrinsic PEEP can be applied except for settings with a large expiratory time. Volume and pressure regulation is possible between 70 and 39% flow restrictor valve closure. Flow restriction in the tested circuit had no effect on the other circuit or on intrinsic PEEP. FiO(2) could be modulated individually between 0.21 and 0.8 by gradually adjusting the additional flow, and minimal affecting FiO(2) in the other circuit. Tidal volumes, PEEP and FiO(2) can be individualized and monitored in a bench testing of a split ventilator. In vivo research is needed to further explore the clinical limitations and outcomes, making implementation possible as a last resort ventilation strategy.
AD  - Department of Emergency Medicine, AZ St-Dimpna, J-B Stessensstraat 2, 2440, Geel, Belgium. michielstiers@hotmail.com.
Department of Critical care Medicine and anesthesiology, AZ St-Dimpna, Geel, Belgium.
Applied Physics/Data Analytics, Vrije Universiteit Brussel, Pleinlaan 2, Brussels, Belgium.
Department of Neurology, AZ St-Dimpna, Geel, Belgium.
Faculty of Medicine and Health Sciences, University of Antwerp, Wilrijk, Belgium.
Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
AN  - 33025322
AU  - Stiers, M.
AU  - Mergeay, M.
AU  - Pinson, H.
AU  - Janssen, L.
AU  - Voets, E.
AU  - De Cauwer, H.
AU  - Schepens, T.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s10877-020-00596-7
DP  - NLM
ET  - 2020/10/08
J2  - Journal of clinical monitoring and computing
KW  - Ards
Bench testing
Covid-19
Individualized split ventilation
LA  - eng
N1  - 1573-2614
Stiers, Michiel
Orcid: 0000-0002-9175-8890
Mergeay, Matthias
Pinson, Hannah
Janssen, Luc
Voets, Evy
De Cauwer, Harald
Schepens, Tom
Journal Article
Netherlands
J Clin Monit Comput. 2020 Oct 6. doi: 10.1007/s10877-020-00596-7.
PY  - 2020
SN  - 1387-1307
ST  - Individualized mechanical ventilation in a shared ventilator setting: limits, safety and technical details
T2  - Journal of clinical monitoring and computing
TI  - Individualized mechanical ventilation in a shared ventilator setting: limits, safety and technical details
ID  - 7790712
ER  - 

TY  - JOUR
AB  - As of May 13, 2020, the number of confirmed SARS-CoV-2 (novel corona virus, COVID-19) infections has risen to 4 300 000 worldwide, with over 1 300 000 confirmed cases in the United States Various prediction models of spread indicate more hospitalization, increased ventilator use, and the shifting of medical resources to most efficiently serve the patient?s needs Additionally, mitigation strategies such as monitoring for symptoms, social distancing, safer at home, and the wearing of masks caused our institution to implement significant operational changes to our usual practice This included screening patients and staff for symptoms, rescheduling routine medical visits, postponing procedures, converting face-to-face visits to telephone or video visits, and changing visitor visit policies In this article, we describe the various ways we deployed empathic communication messaging and resources across the institution during the COVID-19 pandemic
AU  - Stevens, Sheila K.
AU  - Brustad, Rebecca
AU  - Gilbert, Lena
AU  - Houge, Benjamin
AU  - Milbrandt, Timothy
AU  - Munson, Karee
AU  - Packard, Jennifer
AU  - Werneburg, Brooke
AU  - Siddiqui, Mustaqeem A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Use of Empathic Communication During the COVID-19 Outbreak
T2  - Journal of Patient Experience
TI  - The Use of Empathic Communication During the COVID-19 Outbreak
UR  - https://doi.org/10.1177/2374373520962602
ID  - 7792804
ER  - 

TY  - JOUR
AB  - Schools serve an essential function for individuals with autism spectrum disorder (ASD) and complex needs However, school-based instruction may be interrupted due to pandemics, natural disasters, and school shootings, and as a result, schools are forced to stop traditional services and begin teaching students in their homes Fortunately, distance education strategies are available to mitigate brick and mortar interruptions When rural schools close, they face unique challenges, such as proximity to students, and technology limitations In this article, we describe strategies for teachers to develop instructional materials, communication supports, and behavioral supports We also describe how caregivers might provide support, and how to teach caregivers the skills necessary for effective support implementation
AU  - Stenhoff, Donald M.
AU  - Pennington, Robert C.
AU  - Tapp, Melissa C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Distance Education Support for Students With Autism Spectrum Disorder and Complex Needs During COVID-19 and School Closures
T2  - Rural Special Education Quarterly
TI  - Distance Education Support for Students With Autism Spectrum Disorder and Complex Needs During COVID-19 and School Closures
UR  - https://doi.org/10.1177/8756870520959658
ID  - 7792802
ER  - 

TY  - JOUR
AD  - Klinik für Gefäßchirurgie, Gefäßzentrum Barmherzige Brüder Regensburg, Krankenhaus Barmherzige Brüder Regensburg, Prüfeninger Str. 86, 93049 Regensburg, Deutschland. GRID: grid.469954.3. ISNI: 0000 0000 9321 0488
Klinik für Gefäßchirurgie und Endovaskuläre Chirurgie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Deutschland. GRID: grid.5253.1. ISNI: 0000 0001 0328 4908
AN  - 33024354
AU  - Steinbauer, M.
AU  - Böckler, D.
C1  - 10/7/2020
C2  - PMC7531063
DB  - PubMed
DO  - 10.1007/s00772-020-00705-5
DP  - NLM
ET  - 2020/10/08
IS  - 6
J2  - Gefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie
LA  - ger
N1  - Steinbauer, M
Böckler, D
Editorial
Germany
Gefasschirurgie. 2020;25(6):387-388. doi: 10.1007/s00772-020-00705-5. Epub 2020 Oct 2.
OP  - SARS-CoV-2.
PY  - 2020
SN  - 0948-7034 (Print)
0948-7034
SP  - 387-388
ST  - [SARS-CoV-2]
T2  - Gefasschirurgie : Zeitschrift fur vaskulare und endovaskulare Chirurgie : Organ der Deutschen und der Osterreichischen Gesellschaft fur Gefasschirurgie unter Mitarbeit der Schweizerischen Gesellschaft fur Gefasschirurgie
TI  - [SARS-CoV-2]
VL  - 25
ID  - 7790812
ER  - 

TY  - JOUR
AB  - During our annual leadership conference in October, we brought together the leaders of the practice specialities, common interest groups, regions, and councils for leadership training to help them not just as leaders within ASSP, but as leaders within their organizations. [...]last fall, long before the arrival of the pandemic, we demonstrated our ability to create virtual education opportunities by introducing Live Virtual Classroom, bringing virtual participants into our in-person classroom training and enabling safety professionals to receive all the benefits of face-to-face instruction from their home or office. Throughout the year, we continued to advocate publicly on many federal legislative and regulatory matters to bring a strong voice to these issues as a global leader for workplace safety.
AN  - 2448447734
AU  - Stegall, Diana
C1  - 10/7/2020
DA  - Oct 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; ProQuest Central
DP  - ProQuest Central
IS  - 10
KW  - Occupational Health And Safety
Interest groups
Success
Classrooms
Leadership
Councils
Federal regulations
Occupational safety
Pandemics
Professionals
Fiscal years
Training
Coronaviruses
COVID-19
LA  - English
N1  - Copyright - Copyright American Society of Safety Engineers Oct 2020
PY  - 2020
SN  - 00990027
SP  - 9-10
ST  - A MESSAGE FROM THE 2019-20 PRESIDENT
T2  - Professional Safety
TI  - A MESSAGE FROM THE 2019-20 PRESIDENT
UR  - https://www.proquest.com/docview/2448447734?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=unknown&sid=ProQ:ProQ%3Aabiglobal&atitle=A+MESSAGE+FROM+THE+2019-20+PRESIDENT&title=Professional+Safety&issn=00990027&date=2020-10-01&volume=65&issue=10&spage=9&au=Stegall%2C+Diana&isbn=&jtitle=Professional+Safety&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 65
ID  - 7789893
ER  - 

TY  - JOUR
AB  - The current COVID-19 pandemic has rapidly affected a large number of people across the world. In the US, New York and Massachusetts were two states significantly affected early on in the pandemic. Many individuals infected with COVID-19 require hospitalization and following discharge, a subset develop longer-term rehabilitation needs. To address the ongoing rehabilitation needs in this growing population, multidisciplinary teams at academic centers in NYC and Boston designed and implemented post-COVID outpatient clinical recovery programs. In this report, we describe the local development of the outpatient programs and characteristics of the initial patient cohort referred for evaluation. This article is protected by copyright. All rights reserved.
AD  - Spaulding Rehabilitation Hospital, 300 First Street Charlestown, MA, 02129.
VA Boston Healthcare System, 150 S Huntington Ave, Boston, MA, 02130.
Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115.
Massachusetts General Hospital, 55 Fruit Street, Boston, MA, 02114.
Columbia University Irving Medical Center, 180 Fort Washington, St 1-199, New York, NY, 10032.
Weill Cornell Medicine, 156 William Street, New York, NY, 10038.
Newton Wellesley Hospital, 159 Wells Avenue, Newton, MA, 02459.
AN  - 33025674
AU  - Steere, H. K.
AU  - Polich, G.
AU  - Silver, J. K.
AU  - Hameed, F.
AU  - Gellhorn, A. C.
AU  - Borg-Stein, J.
AU  - Schneider, J. C.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1002/pmrj.12506
DP  - NLM
ET  - 2020/10/08
J2  - PM & R : the journal of injury, function, and rehabilitation
KW  - Covid-19
Coronavirus
Occupational Therapy
Pandemics
Physical Therapy
Rehabilitation
SARS CoV-2
Speech Therapy
Telehealth
Telemedicine
LA  - eng
N1  - 1934-1563
Steere, Hannah K
Orcid: 0000-0002-4169-4139
Polich, Ginger
Silver, Julie K
Hameed, Farah
Gellhorn, Alfred C
Orcid: 0000-0002-6020-780x
Borg-Stein, Joanne
Schneider, Jeffrey C
Journal Article
United States
PM R. 2020 Oct 7. doi: 10.1002/pmrj.12506.
PY  - 2020
SN  - 1934-1482
ST  - Ambulatory Rehabilitation of Patients Hospitalized with SARS CoV-2 Infections: Early Pandemic Experience in New York City and Boston
T2  - PM & R : journal of injury, function, and rehabilitation
TI  - Ambulatory Rehabilitation of Patients Hospitalized with SARS CoV-2 Infections: Early Pandemic Experience in New York City and Boston
ID  - 7790687
ER  - 

TY  - JOUR
AU  - Srivastava, Anil K.
AU  - Mishra, Neeraj
AU  - Sethuraman, Lakshmanan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Covid-19 pandemic: The All India Occupational Therapists�?Association’s response to the challenges
T2  - World Federation of Occupational Therapists Bulletin
TI  - Covid-19 pandemic: The All India Occupational Therapists�?Association’s response to the challenges
UR  - https://doi.org/10.1080/14473828.2020.1822578
ID  - 7792957
ER  - 

TY  - JOUR
AB  - The challenge of autoethnography is using my personal experience to explore broader social and political themes and to find a subjective voice to make sense of the impact of the Covid 19 lockdown Using the optic of aging, I explore how I accommodated to quarantine life Sitting and letting the world swirl around me in my house, I explore the altered physical and mental spaces in which I lived Despite my own privileges, I have felt vulnerable and frightened but I have also felt angry and frustrated at the hubris and incompetence with which this crisis has been handled
AU  - Sreberny, Annabelle
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - My Room With a World View: Aging and the Paradoxes of Covid 19
T2  - Qualitative Inquiry
TI  - My Room With a World View: Aging and the Paradoxes of Covid 19
UR  - https://doi.org/10.1177/1077800420962489
ID  - 7792812
ER  - 

TY  - JOUR
AB  - BACKGROUND/AIM: Coronavirus 2019 disease (Covid-19) was first seen in December 2019 and afterwards it became a pandemic. Several systemic involvements have been reported in Covid-19 patients. In this study, it was aimed to investigate the cerebrovascular hemodynamics in patients with Covid-19. MATERIALS AND METHODS: The sample of this study was conducted on 20 patients hospitalized in our clinic diagnosed with Covid-19 via PCR modality and 20 healthy volunteers of similar age and sex. Bilateral middle cerebral arteries were investigated with Transcranial Doppler Ultrasonography. Basal serebral blood flow velocities and vasomotor reactivity rates were determined and compared as statistically. RESULTS: When patient and control groups were compared, the mean blood flow velocity was found to be higher in Covid-19 patients than the healthy volunteers and it was statistically significant (p = 0.00). The mean vasomotor reactivity rates values were found to be lower in Covid-19 group than the healthy group and also it was statistically significant (p = 0.00). CONCLUSION: An increase in cerebral basal blood velocity and a decrease in vasomotor reactivity rates in patients with Covid-19 can be considered as an indicator of dysfunction of cerebral hemodynamics in central nervous system and this can be evaluated as a result of endothelial dysfunction.
AN  - 33021761
AU  - Sonkaya, A. R.
AU  - ÖztÜrk, B.
AU  - KaradaŞ, Ö
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.3906/sag-2006-203
DP  - NLM
ET  - 2020/10/07
J2  - Turkish journal of medical sciences
KW  - Blood flow velocity
Covid-19
SARS-Cov-2
Vasomotor reactivity
LA  - eng
N1  - 1303-6165
Sonkaya, Alİ Riza
ÖztÜrk, Bİlgİn
KaradaŞ, Ömer
Journal Article
Turkey
Turk J Med Sci. 2020 Oct 6. doi: 10.3906/sag-2006-203.
PY  - 2020
SN  - 1300-0144
ST  - Cerebral hemodynamic alterations in patients with Covid-19
T2  - Turkish journal of medical sciences
TI  - Cerebral hemodynamic alterations in patients with Covid-19
ID  - 7791004
ER  - 

TY  - JOUR
AB  - This study investigated consumers�?information-avoidance behavior in the context of a public health emergency—the COVID-19 pandemic in China. Guided by the stimulus-organism-response paradigm, it proposes a model for exploring the effects of external stimuli (perceived threat and perceived information overload) related to COVID-19 on consumers�?internal states (sadness, anxiety, and cognitive dissonance) and their subsequent behavioral intentions to avoid health information and engage in preventive behaviors. With a survey sample (N = 721), we empirically examined the proposed model and tested the hypotheses. The results indicate that sadness, anxiety, and cognitive dissonance, which were a result of perceived threat and perceived information overload, had heterogeneous effects on information avoidance. Anxiety and cognitive dissonance increased information avoidance intention, while sadness decreased information avoidance intention. Moreover, information avoidance predicted a reluctance on the part of consumers to engage in preventive behaviors during the COVID-19 pandemic. These findings not only contribute to the information behavior literature and extend the concept of information avoidance to a public health emergency context, but also yield practical insights for global pandemic control.
AN  - PMC7536537
AU  - Song, Shijie
AU  - Yao, Xinlin
AU  - Wen, Nainan
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.ipm.2020.102407
DP  - NLM
ET  - 2020/10/06
IS  - 1
J2  - Inf Process Manag
KW  - Public health emergency
Information avoidance
Information overload
Sadness
Anxiety
Cognitive dissonance
S-O-R model
LA  - eng
N1  - PMC7536537[pmcid]
S0306-4573(20)30902-X[PII]
PY  - 2021
SN  - 0306-4573
SP  - 102407-102407
ST  - What motivates Chinese consumers to avoid information about the COVID-19 pandemic?: The perspective of the stimulus-organism-response model
T2  - Information Processing & Management
TI  - What motivates Chinese consumers to avoid information about the COVID-19 pandemic?: The perspective of the stimulus-organism-response model
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536537/
VL  - 58
ID  - 7790667
ER  - 

TY  - JOUR
AD  - Baylor College of Medicine, 3989, Pediatric Pulmonary Section, Houston, Texas, United States; mmsockri@texaschildrens.org.
Scripps Clinic and University of California, San Diego, California, United States.
UCSF, Pulmonary & Critical Care Medicine, San Francisco, California, United States.
United States.
Indiana University School of Medicine, 12250, Pulmonary and Critical Care, Indianapolis, Indiana, United States.
AN  - 33021812
AU  - Sockrider, M.
AU  - Jamil, S.
AU  - Santhosh, L.
AU  - Carlos, W. G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1164/rccm.2020C16
DP  - NLM
ET  - 2020/10/07
J2  - American journal of respiratory and critical care medicine
LA  - eng
N1  - 1535-4970
Sockrider, Marianna
Jamil, Shazia
Santhosh, Lekshmi
Carlos, W Graham
Journal Article
United States
Am J Respir Crit Care Med. 2020 Oct 6. doi: 10.1164/rccm.2020C16.
PY  - 2020
SN  - 1073-449x
ST  - COVID-19 Infection versus Influenza (Flu) and Other Respiratory Illnesses
T2  - American journal of respiratory and critical care medicine
TI  - COVID-19 Infection versus Influenza (Flu) and Other Respiratory Illnesses
ID  - 7791003
ER  - 

TY  - JOUR
AB  - The tools of digital health are facilitating a much needed paradigm shift to a more patient-centric health care delivery system, yet our healthcare infrastructure is firmly rooted in a 20th Century model which was not designed to receive medical data from outside the traditional medical environment COVID-19 has accelerated this adoption and illustrated the challenges that lie ahead as we make this shift The diverse ecosystem of digital health tools share one feature in common: they generate data which must be processed, triaged, acted upon and incorporated into the longitudinal electronic health record Critical abnormal findings must be identified and acted upon rapidly, while semi-urgent and non-critical data and trends may be reviewed within a less urgent timeline Clinically irrelevant findings, which presently comprise a significant percentage of the alerts, ideally would be removed to optimize the high cost, high value resource;i e , the clinicians�?attention and time We need to transform our established health care infrastructure, technologies and workflows to be able to safely, effectively and efficiently manage the vast quantities of data that these tools will generate This must include both new technologies from industry as well as expert consensus documents from medical specialty societies including the Heart Rhythm Society Ultimately, research will be fundamental to inform effective development and implementation of these tools
AU  - Slotwiner, David J.
AU  - Al-Khatib, Sana M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Digital Health in Electrophysiology and the COVID-19 Global Pandemic
T2  - Heart Rhythm O2
TI  - Digital Health in Electrophysiology and the COVID-19 Global Pandemic
UR  - https://doi.org/10.1016/j.hroo.2020.09.003
ID  - 7793168
ER  - 

TY  - JOUR
AB  - Pregnant women and new mothers experience numerous biases: they are inappropriately touched, less likely to be hired or promoted, paid less, and subjected to a host of stereotypes Pregnant women and mothers are perceived as warm and maternal, but also incompetent and uncommitted If they return to work, they are perceived as cold, but still incompetent, and uncommitted These stigmas worsen when pregnant women are heavier, as weight-based stigmas add additional biases This article explores the overlapping stigmas of pregnancy, motherhood, and weight in the workplace and higher education Each has implications for policies Addressing the stigmas for pregnant women and mothers will increase diversity in the workforce and higher education The COVID-19 pandemic brings additional pressures on pregnant women and mothers
AU  - Skorinko, Jeanine L. M.
AU  - Incollingo Rodriguez, Angela C.
AU  - Doyle, James K.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Overlapping Stigmas of Pregnancy, Motherhood, and Weight: Policy Implications for Employment and Higher Education
T2  - Policy Insights from Behavioral and Brain Sciences
TI  - Overlapping Stigmas of Pregnancy, Motherhood, and Weight: Policy Implications for Employment and Higher Education
UR  - https://doi.org/10.1177/2372732220943233
ID  - 7792806
ER  - 

TY  - JOUR
AB  - In December 2019, the novel COVID-19 virus spread from a cluster of pneumonia cases in Wuhan, China to every corner of the globe creating a worldwide pandemic pushing hospital systems past capacity and bringing economies worldwide to a halt The COVID-19 pandemic is unique in comparison to prior coronavirus epidemics in its superior ability to be spread by asymptomatic and pre-symptomatic patients allowing the virus to silently evade traditional symptoms-based screening approaches Countries have implemented cutting-edge digital solutions to enhance traditional contact tracing methodologies in combination with novel testing strategies to combat the virus with variable levels of success Despite having one of the most advanced and expensive health care systems in the world, the United States (U S ) response is arguably one of the world’s largest failures as it leads the globe in case number as well as deaths Until a successful vaccine can be broadly distributed, it is imperative the U S curbs the viral spread by rapidly developing a framework implementing both enhanced tracing and testing strategies balancing the needs of public health while respecting individual liberties This review will explore the role of technology augmented contact-based surveillance in tracking the outbreak in select countries in comparison to the current U S approach It will evaluate barriers in the US to implementing similar technologies focusing on privacy concerns and a lack of unified testing and tracing strategy Finally, it will explore strategies for rapidly scaling testing in a cost-effective manner
AU  - Skoll, D.
AU  - Miller, J. C.
AU  - Saxon, L. A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 Testing and Infection Surveillance: Is a Combined Digital Contact Tracing and Mass Testing Solution Feasible in the United States?
T2  - Cardiovascular Digital Health Journal
TI  - COVID-19 Testing and Infection Surveillance: Is a Combined Digital Contact Tracing and Mass Testing Solution Feasible in the United States?
UR  - https://doi.org/10.1016/j.cvdhj.2020.09.004
ID  - 7793193
ER  - 

TY  - JOUR
AD  - Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA. hskali@bwh.harvard.edu.
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. hskali@bwh.harvard.edu.
AN  - 33025475
AU  - Skali, H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s12350-020-02383-y
DP  - NLM
ET  - 2020/10/08
J2  - Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
LA  - eng
N1  - 1532-6551
Skali, Hicham
Editorial
United States
J Nucl Cardiol. 2020 Oct 6. doi: 10.1007/s12350-020-02383-y.
PY  - 2020
SN  - 1071-3581
ST  - The COVID-19 pandemic and nuclear cardiology: An opportunity to grow stronger?
T2  - Journal of nuclear cardiology : official publication of American Society of Nuclear Cardiology
TI  - The COVID-19 pandemic and nuclear cardiology: An opportunity to grow stronger?
ID  - 7790704
ER  - 

TY  - JOUR
AU  - Sivan, Atara
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Reflection on leisure during COVID-19
T2  - World Leisure Journal
TI  - Reflection on leisure during COVID-19
UR  - https://doi.org/10.1080/16078055.2020.1825260
ID  - 7792949
ER  - 

TY  - JOUR
AU  - Sivan, Atara
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Leisure in times of COVID-19: reflection on Hong Kong and Israel
T2  - World Leisure Journal
TI  - Leisure in times of COVID-19: reflection on Hong Kong and Israel
UR  - https://doi.org/10.1080/16078055.2020.1825268
ID  - 7792948
ER  - 

TY  - JOUR
AB  - Tight-fitting FFP3 facemasks are ideal respiratory protective equipment during aerosol generating procedures in Covid-19 environment, and require a Fit Test (FT) to assess mask-face seal competency. Facial hair is considered to be an impediment for achieving a competent seal. We are describing an under-mask beard cover called Singh Thattha technique which obtained a pass rate of 25/27 (92.6%) by qualitative and 5/5 (100%) by quantitative FT in full-bearded individuals. Sturdier versions of FFP3 were more effective. Individuals for whom shaving is not possible, the Singh Thattha technique could offer an effective solution to safely don respirator masks.
AD  - Manchester University Hospitals NHS Foundation Trust. Electronic address: Rajinder.Singh@mft.nhs.uk.
Alton Dental Centre, Hampshire.
Retired NHS GP.
St George's University Hospitals NHS Foundation Trust.
University of Bedfordshire.
NHS Walsall.
AN  - 33022336
AU  - Singh, R. P.
AU  - Safri, H. S.
AU  - Singh, S.
AU  - Alg, G. S.
AU  - Randhawa, G.
AU  - Gill, S. S.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.jhin.2020.09.034
DP  - NLM
ET  - 2020/10/07
J2  - The Journal of hospital infection
LA  - eng
N1  - 1532-2939
Singh, Rajinder Pal
Safri, Hardeep Singh
Singh, Sukhdev
Alg, Gaggandeep Singh
Randhawa, Gurch
Gill, Sukhpal Singh
Journal Article
England
J Hosp Infect. 2020 Oct 3:S0195-6701(20)30459-X. doi: 10.1016/j.jhin.2020.09.034.
PY  - 2020
SN  - 0195-6701
ST  - Bearded individuals can use an under-mask beard cover 'Singh Thattha' for donning respirator masks in Covid-19 patient care
T2  - Journal of hospital infection
TI  - Bearded individuals can use an under-mask beard cover 'Singh Thattha' for donning respirator masks in Covid-19 patient care
ID  - 7790965
ER  - 

TY  - JOUR
AB  - This study examines the impact of the COVID-19 outbreak on the stock markets of G-20 countries We use an event study methodology to measure abnormal returns (ARs) and panel data regression to explain the causes of ARs Our sample consists of indices in G-20 countries The observed window comprises 58 days post the COVID-19 outbreak news release in the international media, and the estimation window consists of 150 days before the event date We find statistically significant negative ARs in the four sub-event windows during the 58 days Negative ARs are significant for developing as well as developed countries The findings of this study reveal that cumulative average abnormal return (CAAR) from day 0 to day 43, ranging from ?0 70 per cent to ?42 69 per cent, is a consequence of increased panic in the stock markets resulting from an increased number of COVID-19 positive cases in the G-20 countries From day 43 to day 57, CAAR ranging from ?42 69 per cent to ?29 77 per cent indicates the recovery of stock markets after a major stock price correction due to COVID-19 Additionally, the results of panel data analysis confirm the recovery of stock markets from the negative impact of COVID-19
AU  - Singh, Bhanwar
AU  - Dhall, Rosy
AU  - Narang, Sahil
AU  - Rawat, Savita
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Outbreak of COVID-19 and Stock Market Responses: An Event Study and Panel Data Analysis for G-20 Countries
T2  - Global Business Review
TI  - The Outbreak of COVID-19 and Stock Market Responses: An Event Study and Panel Data Analysis for G-20 Countries
UR  - https://doi.org/10.1177/0972150920957274
ID  - 7792826
ER  - 

TY  - JOUR
AB  - Introduction In the spot of the new emerging COVID-19 pandemic and its major impact worldwide on day-to-day activities many rules had to be changed in order to fight this pandemic Lockdown started in Jordan and around the globe affecting several aspects of life including economy, education, entertainment, and government policies Regarding education, the priority was to ensure the safety and progress of the educational process Thus, new methods of teaching had to be applied using the online learning at Jordan University of Science and Technology (JUST), Faculty of Medicine This study was done to assess (1) Class Experience (2) Students and Lecturers&#039; Interaction (3) Online Learning Advantages &amp; Disadvantages (4) Students�?Preference Methods A cross sectional study was conducted Convenience sampling technique was used to collect the data from the participants using a survey composed of 18 questions on Google Forms platform A link was sent to the undergraduate medical students at the Jordan University of Science &amp; Technology via their e-learning accounts (n�?�?700) The form was available from May 22nd, 2020 to May 30th, 2020 for 8 days long Data analysis was done using SPSS V 23 Results 2212 out of 3700 students responded, (55 8%) of them were in the basic years and (44 2%) of them were in the clinical years (55 8%) of students started to take online lectures after 3 weeks (45 7%) used the hybrid teaching method (asynchronous and synchronous), (31 4%) used live classes, and 22 8% recorded classes Zoom was the most used platform (48 7%) and (57%) of clinical students and basic students express their interaction as bad, while the others had good and excellent interaction Maintaining social distance was the most advantage of online teaching, while poor technical setup and no direct contact were the most disadvantage, furthermore inability to have real clinical access was a significant problem for clinical students (p�?amp;lt;�?001) With reference to students�?preferences 75% of students were not pleased with their experience and 42% of students prefer to integrate online learning with traditional learning Conclusion Most medical students at JUST preferred the traditional face-to-face teaching method over the solo online teaching methods with recommendations to convert to a more integrated educational system Also, a well-established infrastructure should be done in involving online teaching
AU  - Sindiani, Amer Mahmoud
AU  - Obeidat, Nail
AU  - Alshdaifat, Eman
AU  - Elsalem, Lina
AU  - Alwani, Mustafa M.
AU  - Rawashdeh, Hasan
AU  - Fares, Ahmad S.
AU  - Alalawne, Tamara
AU  - Tawalbeh, Loai Issa
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Distance education during the COVID-19 outbreak: A cross-sectional study among medical students in North of Jordan
T2  - Annals of Medicine and Surgery
TI  - Distance education during the COVID-19 outbreak: A cross-sectional study among medical students in North of Jordan
UR  - https://doi.org/10.1016/j.amsu.2020.09.036
ID  - 7793246
ER  - 

TY  - JOUR
AB  - Emergence of the COVID-19 crisis has catalyzed rapid paradigm shifts throughout medicine. Even after the initial wave of the virus subsides, a wholesale return to the prior status quo is not prudent. As a specialty that values the proper application of new technology, radiation oncology should strive to be at the forefront of harnessing telehealth as an important tool to further optimize patient care. We remain cognizant that telehealth cannot and should not be a comprehensive replacement for in-person patient visits because it is not a one for one replacement, dependent on the intention of the visit and patient preference. However, we envision the opportunity for the virtual patient "room" where multidisciplinary care may take place from every specialty. How we adapt is not an inevitability, but instead, an opportunity to shape the ideal image of our new normal through the choices that we make. We have made great strides toward genuine multidisciplinary patient-centered care, but the continued use of telehealth and virtual visits can bring us closer to optimally arranging the spokes of the provider team members around the central hub of the patient as we progress down the road through treatment.
AD  - Depatment of Radiation Oncology, 25301H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
Virtual Health, 25301H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.
AN  - 33023342
AU  - Sim, A. J.
AU  - Redler, G.
AU  - Peacock, J.
AU  - Naso, C.
AU  - Wasserman, S.
AU  - McNitt, K. B.
AU  - Hoffe, S. E.
AU  - Johnstone, P. A. S.
AU  - Harrison, L. B.
AU  - Rosenberg, S. A.
C1  - 10/7/2020
DA  - Jan-Dec
DB  - PubMed
DO  - 10.1177/1073274820964800
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Cancer control : journal of the Moffitt Cancer Center
KW  - Covid-19
healthcare access
multidisciplinary care
patient-centered care
telehealth
LA  - eng
N1  - 1526-2359
Sim, Austin J
Orcid: 0000-0001-5523-4347
Redler, Gage
Peacock, Jeffrey
Naso, Cristina
Wasserman, Stuart
McNitt, Khadija B
Hoffe, Sarah E
Johnstone, Peter A S
Harrison, Louis B
Rosenberg, Stephen A
Journal Article
United States
Cancer Control. 2020 Jan-Dec;27(1):1073274820964800. doi: 10.1177/1073274820964800.
PY  - 2020
SN  - 1073-2748
SP  - 1073274820964800
ST  - Harnessing COVID-Driven Technical Innovations for Improved Multi-Disciplinary Cancer Care in the Post-COVID Era: The Virtual Patient Room
T2  - Cancer control : journal of Moffitt Cancer Center
TI  - Harnessing COVID-Driven Technical Innovations for Improved Multi-Disciplinary Cancer Care in the Post-COVID Era: The Virtual Patient Room
VL  - 27
ID  - 7790919
ER  - 

TY  - JOUR
AB  - The onset of the COVID-19 pandemic brought an unusual decrease in human activity associated with partial and total lockdowns Simultaneously, a series of wildlife sightings—mainly in urban areas—have been brought to public attention and often attributed to lockdown measures Here we report on a series of wild carnivore records, including threatened species, obtained through camera traps set in urban forests, campuses, suburbs, and peri-urban areas of two cities in Chile, during partial lockdown measures Our records are novel for Chile, a country where urban carnivore ecology is mostly unknown, and include the detection of four native carnivores, including the vulnerable güiña (Leopardus guigna) and the endangered southern river otter (Lontra provocax) These records also constitute a valuable baseline collected during lockdown measures in two cities of the Global South We emphasize, however, that these findings cannot be used to argue for or against an effect of lockdown measures on wildlife More generally, we call for caution in the interpretation of seemingly novel carnivore records during periods of lockdown and stress the value of international collaboration in evaluating the effects of the Anthropause on wildlife
AU  - Silva-Rodr�Tguez, Eduardo A.
AU  - G֙lvez, Nicol֙s Swan
AU  - George, J. F.
AU  - Cusack, Jeremy J.
AU  - Moreira-Arce, Dar�To
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Urban wildlife in times of COVID-19: what can we infer from carnivore sightings in urban areas?
T2  - Science of Total Environment
TI  - Urban wildlife in times of COVID-19: what can we infer from carnivore sightings in urban areas?
UR  - https://doi.org/10.1016/j.scitotenv.2020.142713
ID  - 7793051
ER  - 

TY  - JOUR
AD  - Biological & Biomedical Sciences, Yale University, New Haven, Connecticut, USA.
Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
AN  - 33023703
AU  - Siff, E. J.
AU  - Aghagoli, G.
AU  - Gallo Marin, B.
AU  - Tobin-Tyler, E.
AU  - Poitevien, P.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1017/s095026882000240x
DP  - NLM
ET  - 2020/10/08
J2  - Epidemiology and infection
LA  - eng
N1  - 1469-4409
Siff, Emily J
Orcid: 0000-0001-9111-5273
Aghagoli, Ghazal
Gallo Marin, Benjamin
Orcid: 0000-0003-4877-354x
Tobin-Tyler, Elizabeth
Poitevien, Patricia
Journal Article
England
Epidemiol Infect. 2020 Oct 7:1-16. doi: 10.1017/S095026882000240X.
PY  - 2020
SN  - 0950-2688
SP  - 1-16
ST  - SARS-CoV-2 Transmission: A Sociological Review
T2  - Epidemiology and infection
TI  - SARS-CoV-2 Transmission: A Sociological Review
ID  - 7790885
ER  - 

TY  - JOUR
AB  - [This corrects the article DOI: 10.1371/journal.pmed.1003244.].
AN  - 33022016
AU  - Siedner, M. J.
AU  - Harling, G.
AU  - Reynolds, Z.
AU  - Gilbert, R. F.
AU  - Haneuse, S.
AU  - Venkataramani, A. S.
AU  - Tsai, A. C.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1371/journal.pmed.1003376
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PLoS medicine
LA  - eng
N1  - 1549-1676
Siedner, Mark J
Harling, Guy
Reynolds, Zahra
Gilbert, Rebecca F
Haneuse, Sebastien
Venkataramani, Atheendar S
Tsai, Alexander C
Published Erratum
United States
PLoS Med. 2020 Oct 6;17(10):e1003376. doi: 10.1371/journal.pmed.1003376. eCollection 2020 Oct.
PY  - 2020
SN  - 1549-1277
SP  - e1003376
ST  - Correction: Social distancing to slow the US COVID-19 epidemic: Longitudinal pretest-posttest comparison group study
T2  - PLoS medicine
TI  - Correction: Social distancing to slow the US COVID-19 epidemic: Longitudinal pretest-posttest comparison group study
VL  - 17
ID  - 7790988
ER  - 

TY  - JOUR
AB  - BACKGROUND: COVID-19 pandemic has created unprecedented health and economic impact. Psychological stress, anxiety and depression are affecting not only COVID-19 patients but also health professionals, and general population. Fear of contracting COVID-19, forced restrictive social measures, and economic hardship are causing mental trauma. Nepal is a developing country from South Asia where the COVID-19 pandemic is still evolving. This online survey has been carried out to understand impact of COVID- 19 on mental health of Nepalese community dwellers. METHODS: The COVID-19 Peritraumatic Distress Index (CPDI) questionnaire adapted from the Shanghai Mental Health Centre was used for online data collection from 11 April-17 May 2020. Collected data were extracted to Microsoft excel-13 and imported and analyzed using SPSS (Statistical Package for Social Sciences) version-22. An initial univariate analysis was conducted for all variables to assess the distribution. Logistic regression analyses were done to estimate the odds ratios of relevant predicting variables. RESULTS: A total of 410 participants completed the self-rated questionnaires. Mean age of study participants was 34.8 ±�?1.7 years with male preponderance. 88.5% of the respondents were not in distress (score less than 28) while, 11% had mild to moderate distress and 0.5% had severe distress. The prevalence of distress is higher among age group �?5 years, female gender, and post-secondary education group. Health professional were more likely to get distressed. Respondents with post-secondary education had higher odds (OR�?�?.32; p�?�?.020) of developing distress as compared to respondents with secondary education or lower. CONCLUSION: There is lower rate of psychological distress in city dwellers and people with low education. Adequate intervention and evaluation into mental health awareness, and psychosocial support focused primarily on health care workers, female and elderly individuals is necessary.
AD  - Mangalbare Hospital, Morang, Nepal. medhan75@gmail.com.
Nepalese Army Institute of Health Sciences (NAIHS), Shree Birendra Hospital, Chhauni, Kathmandu, Nepal.
Gandhi International Mission Nepal, Kathmandu, Nepal.
Apex Hospital, Itahari, Nepal.
AN  - 33023563
AU  - Shrestha, D. B.
AU  - Thapa, B. B.
AU  - Katuwal, N.
AU  - Shrestha, B.
AU  - Pant, C.
AU  - Basnet, B.
AU  - Mandal, P.
AU  - Gurung, A.
AU  - Agrawal, A.
AU  - Rouniyar, R.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s12888-020-02904-6
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMC psychiatry
KW  - Covid-19
Mental health
Nepal
Pandemics psychological distress
LA  - eng
N1  - 1471-244x
Shrestha, Dhan Bahadur
Orcid: 0000-0002-8121-083x
Thapa, Bikash Bikram
Orcid: 0000-0001-7513-8854
Katuwal, Nagendra
Shrestha, Bikal
Pant, Chiranjibi
Basnet, Bina
Mandal, Pankaj
Gurung, Amol
Agrawal, Ankita
Rouniyar, Ramhari
Journal Article
England
BMC Psychiatry. 2020 Oct 6;20(1):491. doi: 10.1186/s12888-020-02904-6.
PY  - 2020
SN  - 1471-244x
SP  - 491
ST  - Psychological distress in Nepalese residents during COVID-19 pandemic: a community level survey
T2  - BMC psychiatry
TI  - Psychological distress in Nepalese residents during COVID-19 pandemic: a community level survey
VL  - 20
ID  - 7790902
ER  - 

TY  - JOUR
AB  - Objectives Studies on serologic responses following COVID-19 have been published primarily in individuals who are moderately or severely symptomatic, but there are few data from individuals who are mildly symptomatic or asymptomatic Methods We measured IgG, IgM, and IgA to the receptor-binding domain of SARS-CoV-2 by ELISA in mildly symptomatic (n�?�?08) and asymptomatic (n�?�?3) on days 1, 7, 14, and 30 following RT-PCR confirmation in Bangladesh, and compared with pre-pandemic samples, including healthy controls (n�?�?3) and individuals infected with other viruses (n�?�?9) Results Mildly symptomatic individuals developed IgM and IgA responses by day 14 in 72% and 83% of individuals, respectively, while 95% of individuals developed IgG response, and rose to 100% by day 30 In contrast, individuals infected with SARS-CoV-2 but who remained asymptomatic developed antibody responses significantly less frequently, with only 20% positive for IgA and 22% positive for IgM by day 14, and 45% positive for IgG by day 30 after infection Conclusions These results confirm immune responses are generated following COVID-19 who develop a mildly symptomatic illness However, those with the asymptomatic infection do not respond or have lower antibody levels These results will impact modeling needed for determining herd immunity generated by natural infection or vaccination
AU  - Shirin, Tahmina
AU  - Bhuiyan, Taufiqur Rahman
AU  - Charles, Richelle C.
AU  - Amin, Shaheena
AU  - Bhuiyan, Imran
AU  - Kawser, Zannat
AU  - Rahat, Asifuzaman
AU  - Alam, Ahmed Nawsher
AU  - Sultana, Sharmin
AU  - Aleem, Md Abdul
AU  - Khan, Manjur Hossain
AU  - Khan, Samsad Rabbani
AU  - LaRocque, Regina C.
AU  - Calderwood, Stephen B.
AU  - Ryan, Edward T.
AU  - Slater, Damien M.
AU  - Banu, Sayera
AU  - Clemens, John
AU  - Harris, Jason B.
AU  - Flora, Meerjady Sabrina
AU  - Qadri, Firdausi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh
T2  - International Journal of Infectious Diseases
TI  - Antibody responses after COVID-19 infection in patients who are mildly symptomatic or asymptomatic in Bangladesh
UR  - https://doi.org/10.1016/j.ijid.2020.09.1484
ID  - 7793159
ER  - 

TY  - JOUR
AB  - Objectives. To understand what levels of herd immunity are required in the COVID-19 pandemic, given spatial population heterogeneity, to best inform policy and action. Methods. Using a network of counties in the United States connected by transit data we considered a set of coupled differential equations for susceptible-infectious-removed populations. We calculated the classical herd immunity level plus a version reflecting the heterogeneity of connections in the network by running the model forward in time until the epidemic completed. Results. Necessary levels of herd immunity vary greatly from county to county. A population weighted average for the United States is 47.5% compared to a classically estimated level of 77.1%. Conclusions. Common thinking argues that the nation needs to achieve at least 60% herd immunity to emerge from the COVID-19 pandemic. Heterogeneity in contact structure and individual variation in infectivity, susceptibility, and resistance are key factors that reduce the disease-induced herd immunity levels to 34.2-47.5% in our models. Looking forward toward vaccination strategies, these results suggest we should consider not just who is vaccinated but where those vaccinations will do the most good.Competing Interest StatementThe authors have declared no competing interest.Funding Statementno external funding to reportAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This research is deemed exempt by the UnitedHealth Group IRBAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Yesall data is available via the New York Timeshttps://github.com/nytimes/covid-19-data
AU  - Sheils, Natalie Elizabeth
AU  - Lyng, Gregory D.
AU  - Berke, Ethan M.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20207100
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20207100
ST  - Updating Herd Immunity Models for the U.S. in 2020: Implications for the COVID-19 Response (preprint)
T2  - medRxiv
TI  - Updating Herd Immunity Models for the U.S. in 2020: Implications for the COVID-19 Response (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20207100.abstract
ID  - 7794740
ER  - 

TY  - JOUR
AB  - In December, 2019, a pathogen was identified and named as 2019 novel coronavirus (2019-nCoV). To prevent its spread, lockdowns were announced and working women had to perform dual roles: work from home and work for home. In the present study researchers aimed to assess mental and physical load on Indian women professionals during lockdown due to COVID-19. An online cross-sectional survey was carried out using a Google form. The questionnaire consisted of queries based on following domains: demographic details, awareness of COVID-19 pandemic, analysis of mental health of participants during lockdown, estimate of physical load for work from home, physical load due to house hold chores and overall effect on health. The sample was collected from 28(th) April to 12(th) May 2020 and 537 responses were recorded from women working from home as well as working for home through snowball sampling technique. Mental health was moderately and severely affected in 27.5% and 27% of participants respectively. 34.3% experienced great increase in physical load due to house hold chores during lockdown. 45.81% reported pain in neck and back region with 36.31% participants reported strain in their eyes sometimes. 15.08% and 8.37% had a tendency to over react in the present situation often and always respectively. The women performing work from home and work for home during the lock down are going through moderately increased physical and mental load. Their health is also affected by development of musculoskeletal problems.
AD  - Department of Neurological Physiotherapy, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Ambala, Haryana, India.
Department of Cardiopulmonary Physiotherapy, Maharishi Markandeshwar Institute of Physiotherapy and Rehabilitation, Maharishi Markandeshwar (Deemed to be University), Ambala, Haryana, India.
AN  - 33021925
AU  - Sharma, N.
AU  - Vaish, H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/07399332.2020.1825441
DP  - NLM
ET  - 2020/10/07
J2  - Health care for women international
LA  - eng
N1  - 1096-4665
Sharma, Nidhi
Orcid: 0000-0003-3999-1780
Vaish, Hina
Orcid: 0000-0001-6045-845x
Journal Article
England
Health Care Women Int. 2020 Oct 6:1-18. doi: 10.1080/07399332.2020.1825441.
PY  - 2020
SN  - 0739-9332
SP  - 1-18
ST  - Impact of COVID - 19 on mental health and physical load on women professionals: an online cross-sectional survey
T2  - Health care for women international
TI  - Impact of COVID - 19 on mental health and physical load on women professionals: an online cross-sectional survey
ID  - 7790995
ER  - 

TY  - JOUR
AB  - Background /Objective: There is a paucity of data on the management of gastrointestinal (GI) bleeding in patients with COVID-19 amid concerns about the risk of transmission during endoscopic procedures We aimed to study the outcomes of conservative treatment for GI bleeding in patients with COVID-19 Methods In this retrospective analysis, 24 of 1342 (1 8%) patients with COVID-19, presenting with GI bleeding from 22 April to 22 July 2020, were included Results The mean age of patients was 45 8�u12 7 years;17 (70 8%) were males;upper GI (UGI) bleeding: lower GI (LGI) 23:1 Twenty-two (91 6%) patients had evidence of cirrhosis- 21 presented with UGI bleeding while one had bleeding from hemorrhoids Two patients without cirrhosis were presumed to have non-variceal bleeding The medical therapy for UGI bleeding included vasoconstrictors-somatostatin in 17 (73 9%) and terlipressin in 4 (17 4%) patients All patients with UGI bleeding received proton pump inhibitors and antibiotics Packed red blood cells (PRBCs), fresh frozen plasma and platelets were transfused in 14 (60 9%), 3 (13 0%) and 3 (13 0%), respectively The median PRBCs transfused was 1 (0-3) unit(s) The initial control of UGI bleeding was achieved in all 23 patients and none required an emergency endoscopy At 5-day follow-up, none rebled or died Two patients later rebled, one had intermittent bleed due to gastric antral vascular ectasia, while another had rebleed 19 days after discharge Three (12 5%) cirrhosis patients succumbed to acute hypoxemic respiratory failure during hospital stay Conclusion Conservative management strategies including pharmacotherapy, restrictive transfusion strategy, and close hemodynamic monitoring can successfully manage GI bleeding in COVID-19 patients and reduce need for urgent endoscopy The decision for proceeding with endoscopy should be taken by a multidisciplinary team after consideration of the patient&#039;s condition, response to treatment, resources and the risks involved, on a case to case basis
AU  - Shalimar, D. M.
AU  - Vaishnav, Manas
AU  - Elhence, Anshuman
AU  - Kumar, Ramesh
AU  - Mohta, Srikant
AU  - Palle, Chandan
AU  - Kumar, Peeyush
AU  - Ranjan, Mukesh
AU  - Vajpai, Tanmay
AU  - Prasad, Shubham
AU  - Yegurla, Jatin
AU  - Dhooria, Anugrah
AU  - Banyal, Vikas
AU  - Agarwal, Samagra
AU  - Bansal, Rajat
AU  - Bhattacharjee, Sulagna
AU  - Aggarwal, Richa
AU  - Soni, Kapil Dev
AU  - Rudravaram, Swetha
AU  - Singh, Ashutosh Kumar
AU  - Altaf, Irfan
AU  - Choudekar, Avinash
AU  - Mahapatra, Soumya Jagannath
AU  - Gunjan, Deepak
AU  - Kedia, Saurabh
AU  - Makharia, Govind
AU  - Trikha, Anjan
AU  - Garg, Pramod
AU  - Saraya, Anoop
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Outcome of Conservative Therapy in COVID-19 Patients Presenting with Gastrointestinal Bleeding
T2  - Journal of Clinical and Experimental Hepatology
TI  - Outcome of Conservative Therapy in COVID-19 Patients Presenting with Gastrointestinal Bleeding
UR  - https://doi.org/10.1016/j.jceh.2020.09.007
ID  - 7793141
ER  - 

TY  - JOUR
AB  - Vaccination practices in Germany are driven by scientific developments and a complex regulatory environment. Some important developments in 2019/20 are described here: Work-related vaccination recommendations for measles, rubella, and chickenpox have been streamlined and expanded. In addition, measles vaccination or documentation of immunity is now mandatory for employment at and attendance of many institutions, specifically including day care centers and schools. Owing to the shift of pneumococcal serotypes since the introduction of conjugate vaccines the US ACIP no longer recommends these for the routine administration to healthy persons of older age. Reduced series of 2 or even 1 dose of an HPV vaccine may be sufficient, however definitive RCT data are not yet available. After years of development and clinical studies the first vaccine against Ebolavirus disease has been licensed by EMA in November and by FDA in December 2019. More than 150 SARS-CoV-2 vaccine candidates are being developed with massive financial support, several phase 1/2 trials have started. A licensed vaccine may actually be available in 2021 and thus dramatically faster compared to any other modern vaccine development.
AD  - Medizinische Klinik und Poliklinik IV, Sektion Klinische Infektiologie, Klinikum der Ludwig-Maximilians-Universität, München.
AN  - 33022727
AU  - Seybold, U.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1055/a-0982-8894
DP  - NLM
ET  - 2020/10/07
IS  - 20
J2  - Deutsche medizinische Wochenschrift (1946)
LA  - ger
N1  - 1439-4413
Seybold, Ulrich
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 2020 Oct;145(20):1464-1468. doi: 10.1055/a-0982-8894. Epub 2020 Oct 6.
OP  - Neues zu Impfungen bei Erwachsenen.
PY  - 2020
SN  - 0012-0472
SP  - 1464-1468
ST  - [Vaccines for adults: an update]
T2  - Deutsche medizinische Wochenschrift (1946)
TI  - [Vaccines for adults: an update]
VL  - 145
ID  - 7790951
ER  - 

TY  - JOUR
AN  - 33021445
AU  - Sert, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0194599820964728
DP  - NLM
ET  - 2020/10/07
J2  - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
LA  - eng
N1  - 1097-6817
Sert, Ahmet
Letter
England
Otolaryngol Head Neck Surg. 2020 Oct 6:194599820964728. doi: 10.1177/0194599820964728.
PY  - 2020
SN  - 0194-5998
SP  - 194599820964728
ST  - A New Syndrome and Kawasaki Disease Associated With SARS-CoV-2 in Otolaryngology Practice
T2  - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
TI  - A New Syndrome and Kawasaki Disease Associated With SARS-CoV-2 in Otolaryngology Practice
ID  - 7791030
ER  - 

TY  - JOUR
AB  - A safe and effective vaccine that can provide herd immunity against severe acute respiratory syndrome coronavirus (SARS-CoV-2) is urgently needed to stop the spread of this virus among humans. Many human viral vaccines are live, attenuated forms of viruses that elicit humoral and cellular immunity. Here, we describe a cold-adapted live-attenuated vaccine (SARS-CoV-2/human/Korea/CNUHV03-CA22 ��C/2020) developed by gradually adapting the growth of SARS-CoV-2 from 37 ��C to 22 ��C in Vero cells. This vaccine can be potentially administered to humans as a nasal spray. Its single dose strongly induced neutralising antibodies (titre  640), cellular immunity, and mucosal IgA antibodies in intranasally immunised K18-hACE2 mice, which are very susceptible to SARS-CoV-2 and SARS-CoV infections. The one-dose vaccinated mice were completely protected from SARS-CoV-2 infection and did not show body weight loss, death, or the presence of virus in tissues, such as the nasal turbinates, brain, lungs, and kidneys. These results demonstrate that the cold-adapted live attenuated SARS-CoV-2 vaccine we have developed may be a candidate SARS-CoV-2 vaccine for humans.
AD  - Laboratory of Influenza Research, College of Veterinary Medicine, Daejeon 34134, Korea.
Institute of Influenza Virus, Chungnam National University, Daejeon 34134, Korea.
AN  - 33022950
AU  - Seo, S. H.
AU  - Jang, Y.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/vaccines8040584
DP  - NLM
ET  - 2020/10/08
IS  - 4
J2  - Vaccines
KW  - SARS-CoV-2
cold adaptation
live attenuated vaccine
LA  - eng
N1  - Seo, Sang Heui
Orcid: 0000-0001-9639-8786
Jang, Yunyueng
Orcid: 0000-0001-5616-6999
Journal Article
Switzerland
Vaccines (Basel). 2020 Oct 3;8(4):E584. doi: 10.3390/vaccines8040584.
PY  - 2020
SN  - 2076-393X (Print)
2076-393x
ST  - Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection
T2  - Vaccines
TI  - Cold-Adapted Live Attenuated SARS-Cov-2 Vaccine Completely Protects Human ACE2 Transgenic Mice from SARS-Cov-2 Infection
VL  - 8
ID  - 7790932
ER  - 

TY  - JOUR
AB  - In the novel coronavirus (COVID-19) pandemic, preventive medicine has taken center stage, as there is no vaccine or specific antiviral drug regime used to treat patients. Public health authorities and governments are recommending the practice of social distancing and hand hygiene. Hands are a common vector for the transmission of infection, and frequent face touching is extremely common among the public. We developed and applied a new method to prevent face touching which is of utmost importance to break its cycle and subsequent inoculation of the virus through mucous membranes, thus reducing the risk of transmission of COVID-19. HOW TO CITE THIS ARTICLE: Senthilkumaran S, Arathisenthil SV, Meenakshisundaram R, Thirumalaikolundusubramanian P. Not Touching the Face is Harder Than It Sounds: Need for an Intervention. Indian J Crit Care Med 2020;24(8):662-663.
AD  - Department of Emergency and Critical Care, Manian Medical Centre, Erode, Tamil Nadu, India.
Department of Dentistry, Manian Medical Centre, Erode, Tamil Nadu, India.
Department of Internal Medicine, Trichy SRM Medical College Hospital and Research Centre, Irungalur, Trichy, Tamil Nadu, India.
AN  - 33024371
AU  - Senthilkumaran, S.
AU  - Arathisenthil, S. V.
AU  - Meenakshisundaram, R.
AU  - Thirumalaikolundusubramanian, P.
C1  - 10/7/2020
C2  - PMC7519609
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23527
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Covid-19
Infection control practices
Prevention
LA  - eng
N1  - Senthilkumaran, Subramanian
Arathisenthil, S V
Meenakshisundaram, Ramachandran
Thirumalaikolundusubramanian, Ponniah
Journal Article
India
Indian J Crit Care Med. 2020 Aug;24(8):662-663. doi: 10.5005/jp-journals-10071-23527.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 662-663
ST  - Not Touching the Face is Harder Than It Sounds: Need for an Intervention
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - Not Touching the Face is Harder Than It Sounds: Need for an Intervention
VL  - 24
ID  - 7790807
ER  - 

TY  - JOUR
AD  - From the Gazi University Faculty of Medicine, Department of Radiology, Mevlana Bulvar�\ No:29 06560 Yenimahalle, Ankara, Turkey.
AN  - 33021896
AU  - Şendur, H. N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1148/radiol.2020203627
DP  - NLM
ET  - 2020/10/07
J2  - Radiology
LA  - eng
N1  - 1527-1315
Şendur, Halit Nahit
Orcid: 0000-0003-1690-2538
Letter
United States
Radiology. 2020 Oct 6:203627. doi: 10.1148/radiol.2020203627.
PY  - 2020
SN  - 0033-8419
SP  - 203627
ST  - Debate of Chest CT and RT-PCR Test for the Diagnosis of COVID-19
T2  - Radiology
TI  - Debate of Chest CT and RT-PCR Test for the Diagnosis of COVID-19
ID  - 7790997
ER  - 

TY  - JOUR
AB  - Seven members of the Coronaviridae family infect humans, but only three (SARS-CoV, SARS-CoV-2 and MERS-CoV) cause severe disease with a high case fatality rate. Using in silico analyses (machine learning techniques and comparative genomics), several features associated to coronavirus pathogenicity have been recently proposed, including a potential increase in the strength of a predicted novel nuclear export signal (NES) motif in the nucleocapsid protein. Here, we have used a well-established nuclear export assay to experimentally establish whether the recently proposed nucleocapsid NESs are capable of mediating nuclear export, and to evaluate if their activity correlates with coronavirus pathogenicity. The six NES motifs tested were functional in our assay, but displayed wide differences in export activity. Importantly, these differences in NES strength were not related to strain pathogenicity. Rather, we found that the NESs of the strains belonging to the genus Alphacoronavirus were markedly stronger than the NESs of the strains belonging to the genus Betacoronavirus. We conclude that, while some of the genomic features recently identified in silico could be crucial contributors to coronavirus pathogenicity, this does not appear to be the case of nucleocapsid NES activity, as it is more closely related to coronavirus genus than to pathogenic capacity.Competing Interest StatementThe authors have declared no competing interest.
AU  - Sendino, Maria
AU  - Omaetxebarria, Miren Josu
AU  - Rodriguez, Jose A.
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.328138
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.328138
ST  - The strength of a NES motif in the nucleocapsid protein of human coronaviruses is related to genus, but not to pathogenic capacity (preprint)
T2  - bioRxiv
TI  - The strength of a NES motif in the nucleocapsid protein of human coronaviruses is related to genus, but not to pathogenic capacity (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.328138.abstract
ID  - 7794719
ER  - 

TY  - JOUR
AB  - Objective The purpose of this study was to assess parent satisfaction with the management of ketogenic diet therapies (KDTs) through telemedicine using WhatsApp as the main tool Methods Parent satisfaction was longitudinally evaluated through questionnaires The survey was developed with Google Questionnaire forms and sent via WhatsApp The questionnaire consisted of 13 items concerning the management of KDTs using telemedicine in the context of the coronavirus disease 2019 (COVID-19) pandemic Our population of patients has limited financial resources and low levels of education Given that many families did not have either computers or WIFI, or any other access to information or communication technology, WhatsApp was chosen as a tool as it was available on the cell phones of all families and the professionals Results Our survey showed that 96 3% of the parents were satisfied with the management of KDTs through telemedicine The main benefits observed were the possibility of continuing treatment during the COVID-19 pandemic and the ease of accessing the professional team from the comfort of their home Overall, 72 2% of the families would recommend using telemedicine for KDTs in any situation regardless of the pandemic None of the families reported that they would recommend against treatment by telemedicine The availability of a social support network (parents WhatsApp group) coordinated by professionals from the KDT team was considered to be useful by most respondents (90%) Conclusions Our study suggests that management of children with DRE on KDTs through telemedicine is feasible, well accepted by the families, and probably as safe as conventional medicine WhatsApp may be an interesting telemedicine tool to start and maintain KDTs
AU  - Semprino, Marcos
AU  - Fasulo, Lorena
AU  - Fortini, Sebastian
AU  - Martorell Molina, Catalina Isabel
AU  - Gonz֙lez, Lara
AU  - Ramos, Paola Alejandra
AU  - Mart�Tnez, Carolina
AU  - Caraballo, Roberto
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Telemedicine, drug-resistant epilepsy, and ketogenic dietary therapies: A patient survey of a pediatric remote-care program during the COVID-19 pandemic
T2  - Epilepsy & Behavior
TI  - Telemedicine, drug-resistant epilepsy, and ketogenic dietary therapies: A patient survey of a pediatric remote-care program during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.yebeh.2020.107493
ID  - 7793038
ER  - 

TY  - JOUR
AU  - Seelhammer, Troy G.
AU  - Plack, Daniel
AU  - Lal, Amos
AU  - Nabzdyk, Christoph G. S.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 and ECMO: An Unhappy Marriage of Endothelial Dysfunction and Hemostatic Derangements
T2  - Journal of Cardiothoracic and Vascular Anesthesia
TI  - COVID-19 and ECMO: An Unhappy Marriage of Endothelial Dysfunction and Hemostatic Derangements
UR  - https://doi.org/10.1053/j.jvca.2020.09.132
ID  - 7792994
ER  - 

TY  - JOUR
AB  - The chapters are bookended by K. Latte's 1935 monograph, offering a lengthy treatment of Sallust's style, influences and context (by far the longest entry in the volume, at 60 pages), and P.J. Osmond's 1995 study of Sallust's reception in Renaissance political thought. The selection and organisation of the chapters is sensible and balanced, and the editors are to be commended for undertaking the difficult task of paring down the body of work on Sallust in a way that does the Latin author justice and will sow the seeds of much future study and research. In today's world, when the practice and role of history is so contested �?think of the conflicts surrounding controversial monuments, what material is included in and excluded from school history textbooks, and the bias and partisanship of those who write history �? the editors stress that Sallust's importance extends far beyond his Latin style and literary influences, or his interpretation of the causes of the decline of the Roman Republic. The chapter is wide-ranging and, instead of merely providing a summary or a selection of proof-texts of Sallust references in various Renaissance authors, offers a close analysis of the ways in which political thought changed over the course of the Renaissance and how Sallust was brought to bear to bolster at one time republicanism and at another monarchy.
AD  - University of New Brunswick ; University of New Brunswick
AN  - 2448558941
AU  - Sears, Matthew A.
C1  - 10/7/2020
DA  - Oct 2020
2020-10-06
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1017/S0009840X20000591
DP  - ProQuest Central
IS  - 2
KW  - Classical Studies
Writers
Historians
Partisanship
Medieval period
Politics
COVID-19
United States--US
LA  - English
N1  - Name - Oxford University Press
Copyright - Copyright © The Classical Association 2020
SubjectsTermNotLitGenreText - United States--US
PY  - 2020
SN  - 0009840X
SP  - 381-383
ST  - SCHOLARSHIP ON SALLUST: Sallust. Oxford Readings in Classical Studies. Pp. xii + 494, ills. Oxford: Oxford University Press, 2020. Cased, �n100, US$130. ISBN: 978-0-19-879098-3
T2  - Classical Review
TI  - SCHOLARSHIP ON SALLUST: Sallust. Oxford Readings in Classical Studies. Pp. xii + 494, ills. Oxford: Oxford University Press, 2020. Cased, �n100, US$130. ISBN: 978-0-19-879098-3
UR  - https://www.proquest.com/docview/2448558941?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aartshumanities&atitle=SCHOLARSHIP+ON+SALLUST%3A+Sallust.+Oxford+Readings+in+Classical+Studies.+Pp.+xii+%2B+494%2C+ills.+Oxford%3A+Oxford+University+Press%2C+2020.+Cased%2C+%26pound%3B100%2C+US%24130.+ISBN%3A+978-0-19-879098-3+.&title=The+Classical+Review&issn=0009840X&date=2020-10-01&volume=70&issue=2&spage=381&au=Sears%2C+Matthew+A&isbn=&jtitle=The+Classical+Review&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1017%2FS0009840X20000591
VL  - 70
ID  - 7789885
ER  - 

TY  - JOUR
AD  - Department of Gastroenterology and Hepatology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Department of Medical Humanities, Julius Center, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands.
AN  - 33025718
AU  - Schuitenmaker, J. M.
AU  - Oude Nijhuis, R. A. B.
AU  - Bredenoord, A. L.
AU  - Fockens, P.
AU  - Bredenoord, A. J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/nmo.14011
DP  - NLM
ET  - 2020/10/08
J2  - Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
LA  - eng
N1  - 1365-2982
Schuitenmaker, Jeroen M
Orcid: 0000-0002-1213-3551
Oude Nijhuis, Renske A B
Orcid: 0000-0003-3678-2019
Bredenoord, Annelien L
Orcid: 0000-0002-7542-8963
Fockens, Paul
Orcid: 0000-0002-2382-0672
Bredenoord, Albert J
Orcid: 0000-0001-5918-2062
Journal Article
England
Neurogastroenterol Motil. 2020 Oct 6:e14011. doi: 10.1111/nmo.14011.
PY  - 2020
SN  - 1350-1925
SP  - e14011
ST  - Investigator initiated research in times of COVID-19: Let's go digital!
T2  - Neurogastroenterology and motility : official journal of European Gastrointestinal Motility Society
TI  - Investigator initiated research in times of COVID-19: Let's go digital!
ID  - 7790684
ER  - 

TY  - JOUR
AB  - On August 24, 2020, the Centers for Disease Control and Prevention (CDC) updated its website to highlight that asymptomatic individuals, even those with exposure to a COVID-19 positive contact, do not necessarily need to be tested unless they have medical conditions associated with increased risk of severe illness from COVID-19. The CDC subsequently updated its guidance on September 19, 2020 to support testing of asymptomatic persons, including close contacts of persons with documented SARS-CoV-2 infection. In this editorial, the American Society for Microbiology Clinical and Public Health Microbiology Committee's Subcommittee on Laboratory Practices comments on testing of asymptomatic individuals relative to current medical knowledge of the virus and mitigation measures. Specific points are provided concerning such testing when undertaking contact tracing and routine surveillance. Limitations to consider when testing asymptomatic persons are covered, including the need to prioritize testing of contacts of positive COVID-19 cases. We urge the CDC to consult with primary stakeholders of COVID-19 testing when making such impactful changes in testing guidance.
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Public Health Laboratories, LA County Department of Public Health, Downey, CA.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT.
Department of Laboratory Medicine, Yale School of Medicine, West Haven, CT.
Pathology and Laboratory Medicine, VA Connecticut Health Care, West Haven, CT.
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Department of Pathology, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC.
Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA.
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC. Editor, Journal of Clinical Microbiology. Melissa.Miller@unchealth.unc.edu.
AN  - 33023910
AU  - Schuetz, A. N.
AU  - Hemarajata, P.
AU  - Mehta, N.
AU  - Campbell, S.
AU  - Mitchell, S.
AU  - Palavecino, E.
AU  - Butler-Wu, S.
AU  - Miller, M. B.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1128/jcm.02563-20
DP  - NLM
ET  - 2020/10/08
J2  - Journal of clinical microbiology
LA  - eng
N1  - 1098-660x
Schuetz, Audrey N
Orcid: 0000-0002-5837-270x
Hemarajata, Peera
Mehta, Ninad
Orcid: 0000-0002-9956-1849
Campbell, Sheldon
Mitchell, Stephanie
Orcid: 0000-0002-1777-7591
Palavecino, Elizabeth
Butler-Wu, Susan
Orcid: 0000-0001-5372-8706
Miller, Melissa B
Editorial
United States
J Clin Microbiol. 2020 Oct 6:JCM.02563-20. doi: 10.1128/JCM.02563-20.
PY  - 2020
SN  - 0095-1137
ST  - When Should Asymptomatic Persons Be Tested for COVID-19?
T2  - Journal of clinical microbiology
TI  - When Should Asymptomatic Persons Be Tested for COVID-19?
ID  - 7790864
ER  - 

TY  - JOUR
AB  - Two mathematical models of the COVID-19 dynamics are considered as the health system in some country consists in a network of regional hospital centers The first macroscopic model for the virus dynamics at the level of the general population of the country is derived from a standard SIR model The second local model refers to a single node of the health system network, i e it models the flows of patients with a smaller granularity at the level of a regional hospital care center for COVID-19 infected patients Daily (low cost) data are easily collected at this level, and are worked out for a fast evaluation of the local health status thanks to control systems methods Precisely, the identifiability of the parameters of the hospital model is proven and thanks to the availability of clinical data, essential characteristics of the local health status are identified Those parameters are meaningful not only to alert on some increase of the infection, but also to assess the efficiency of the therapy and health policy
AU  - Scharbarg, Emeric
AU  - Moog, Claude H.
AU  - Mauduit, Nicolas
AU  - Califano, Claudia
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves
T2  - Annual Reviews in Control
TI  - From the hospital scale to nationwide: observability and identification of models for the COVID-19 epidemic waves
UR  - https://doi.org/10.1016/j.arcontrol.2020.09.007
ID  - 7793229
ER  - 

TY  - JOUR
AB  - The current Covid-19 Pandemic caused by the highly contagious SARS-CoV-2 virus has proven extremely difficult to prevent or control. Currently there are few treatment options and very few long-lasting disinfectants available to prevent the spread. While masks and protective clothing and social distancing may offer some protection, their use has not always halted or slowed the spread. Several vaccines are currently undergoing testing; however there is still a critical need to provide new methods for inactivating the virus before it can spread and infect humans. In the present study we examined the inactivation of SARS-CoV-2 by synthetic conjugated polymers and oligomers developed in our laboratories as antimicrobials for bacteria, fungi and non-enveloped viruses. Our results show that we can obtain highly effective light induced inactivation with several of these oligomers and polymers including irradiation with near-UV and visible light. With both the oligomers and polymers, we can reach several logs of inactivation with relatively short irradiation times. Our results suggest several applications involving the incorporation of these materials in wipes, sprays, masks and clothing and other Personal Protection Equipment (PPE) that can be useful in preventing infections and the spreading of this deadly virus and future outbreaks from similar viruses.Competing Interest StatementK. Schanze and D. Whitten have an interest in BioSafe, LLC which has licensed conjugated polymers and oligomers for use as antimicrobials.Funding StatementWork was supported in part by the following sources of funding: NIH grant 1K22AI141680-01A1 Welch Foundation Grant Grant AX-0045-20110629 None of the authors received payment for any aspect of the work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No IRB approval was needed for the study.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData can be provided upon request.
AU  - Schanze, Kirk S.
AU  - Whitten, David G.
AU  - Kell, Alison M.
AU  - Chi, Eva Y.
AU  - Ista, Linnea K.
AU  - Monge, Florencia A.
AU  - Jagadesan, Pradeepkumar
AU  - Bondu, Virginie
AU  - Donabedian, Patrick L.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.09.29.20204164
DP  - medRxiv
PY  - 2020
SP  - 2020.09.29.20204164
ST  - Highly Effective Inactivation of SARS-CoV-2 by Conjugated Polymers and Oligomers (preprint)
T2  - medRxiv
TI  - Highly Effective Inactivation of SARS-CoV-2 by Conjugated Polymers and Oligomers (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.09.29.20204164.abstract
ID  - 7794728
ER  - 

TY  - JOUR
AB  - Scham conveys that in mid-Mar 2020, events, priorities and attitudes are changing at a dizzying speed. Everything is eclipsed by fear and apprehension regarding the coronavirus. Even before the virus took front and center, the rapid reversal in the political fortunes of Bernie Sanders and Joe Biden as a result of the South Carolina primary on Feb 29 and Super Tuesday on Mar 3 meant that most Democrats (though by no means all) accepted that they would almost certainly be relying on Joe Biden to defeat Donald Trump in the November elections, which is their overwhelming priority. Under these circumstances, the "Deal of the Century" seems farther than ancient history; rather, it feels like it took place in another universe. The fact that another (apparently inconclusive) Israeli election was held on Mar 2 was barely a blip for most of those outside the comparatively small circle of dedicated and passionate Israel-watchers. Benny Gantz's appointment to try to form a new Israeli government received only a brief mention in the news after the extensive coverage of the coronavirus crisis.
AD  - University of Maryland ; University of Maryland
AN  - 2448460092
AU  - Scham, Paul
C1  - 10/7/2020
DA  - 2020
2020-10-05
DB  - ProQuest Central
DP  - ProQuest Central
IS  - 1/2
KW  - History--History Of The Near East
Military aid
Anxiety
Appointment
Universe
Policy reform
Political parties
News
Policy making
Peace negotiations
Attitudes
Candidates
Coronaviruses
Appointments
Jews
Elections
Ancient history
Biden, Joseph R Jr
United States--US
Warren, Elizabeth
Israel
LA  - English
N1  - Name - Congress; Democratic Party
Copyright - Copyright Middle East Publications 2020
People - Warren, Elizabeth; Biden, Joseph R Jr
SubjectsTermNotLitGenreText - United States--US; Israel; Warren, Elizabeth; Biden, Joseph R Jr
PY  - 2020
SN  - 07931395
SP  - 121-126
ST  - American Reaction to Trump's "Dealof the Century": Can U.s. Policy Change?
T2  - Palestine - Israel Journal of Politics, Economics, and Culture
TI  - American Reaction to Trump's "Dealof the Century": Can U.s. Policy Change?
UR  - https://www.proquest.com/docview/2448460092?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=unknown&sid=ProQ:ProQ%3Aabiglobal&atitle=American+Reaction+to+Trump%27s+%26quot%3BDealof+the+Century%26quot%3B%3A+Can+U.s.+Policy+Change%3F&title=Palestine+-+Israel+Journal+of+Politics%2C+Economics%2C+and+Culture&issn=07931395&date=2020-01-01&volume=25&issue=1%2F2&spage=121&au=Scham%2C+Paul&isbn=&jtitle=Palestine+-+Israel+Journal+of+Politics%2C+Economics%2C+and+Culture&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 25
ID  - 7789904
ER  - 

TY  - JOUR
AB  - AIM: To describe the neuroradiological changes in patients with coronavirus disease 2019 (COVID-19). MATERIALS AND METHODS: A retrospective review was undertaken of 3,403 patients who were confirmed positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and admitted to Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK between 1 March 2020 and 31 May 2020, and who underwent neuroimaging. Abnormal brain imaging was evaluated in detail and various imaging patterns on magnetic resonance imaging MRI were identified. RESULTS: Of the 3,403 patients with COVID-19, 167 (4.9%) had neurological signs or symptoms warranting neuroimaging. The most common indications were delirium (44/167, 26%), focal neurology (37/167, 22%), and altered consciousness (34/167, 20%). Neuroimaging showed abnormalities in 23% of patients, with MRI being abnormal in 20 patients and computed tomography (CT) in 18 patients. The most consistent neuroradiological finding was microhaemorrhage with a predilection for the splenium of the corpus callosum (12/20, 60%) followed by acute or subacute infarct (5/20, 25%), watershed white matter hyperintensities (4/20, 20%), and susceptibility changes on susceptibility-weighted imaging (SWI) in the superficial veins (3/20, 15%), acute haemorrhagic necrotising encephalopathy (2/20, 10%), large parenchymal haemorrhage (2/20, 10%), subarachnoid haemorrhage (1/20, 5%), hypoxic-ischaemic changes (1/20, 5%), and acute disseminated encephalomyelitis (ADEM)-like changes (1/20, 5%). CONCLUSION: Various imaging patterns on MRI were observed including acute haemorrhagic necrotising encephalopathy, white matter hyperintensities, hypoxic-ischaemic changes, ADEM-like changes, and stroke. Microhaemorrhages were the most common findings. Prolonged hypoxaemia, consumption coagulopathy, and endothelial disruption are the likely pathological drivers and reflect disease severity in this patient cohort.
AD  - Department of Neuroradiology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; University of Birmingham, Birmingham, UK. Electronic address: Vijay.Sawlani@uhb.nhs.uk.
Department of Neurology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
University of Birmingham, Birmingham, UK; Department of Neurology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Department of Neuroradiology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; University of Birmingham, Birmingham, UK.
Department of Neuroradiology, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, Queen Square, London, UK.
University of Birmingham, Birmingham, UK; Department of Intensive Care, Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
AN  - 33023738
AU  - Sawlani, V.
AU  - Scotton, S.
AU  - Jacob, S.
AU  - Nader, K.
AU  - Jen, J. P.
AU  - Patel, M.
AU  - Gokani, K.
AU  - Denno, P.
AU  - Thaller, M.
AU  - Englezou, C.
AU  - Janjua, U.
AU  - Bowen, M.
AU  - Hoskote, C.
AU  - Veenith, T.
AU  - Hassan-Smith, G.
C1  - 10/7/2020
DA  - Sep 15
DB  - PubMed
DO  - 10.1016/j.crad.2020.09.002
DP  - NLM
ET  - 2020/10/08
J2  - Clinical radiology
LA  - eng
N1  - 1365-229x
Sawlani, V
Scotton, S
Jacob, S
Nader, K
Jen, J P
Patel, M
Gokani, K
Denno, P
Thaller, M
Englezou, C
Janjua, U
Bowen, M
Hoskote, C
Veenith, T
Hassan-Smith, G
Journal Article
England
Clin Radiol. 2020 Sep 15:S0009-9260(20)30392-5. doi: 10.1016/j.crad.2020.09.002.
PY  - 2020
SN  - 0009-9260
ST  - COVID-19-related intracranial imaging findings: a large single-centre experience
T2  - Clinical radiology
TI  - COVID-19-related intracranial imaging findings: a large single-centre experience
ID  - 7790882
ER  - 

TY  - JOUR
AB  - Background: SARS-CoV-2 is found in conjunctival swabs and tears of COVID-19 patients. However, the presence of SARS-CoV-2 has not been detected in the human eye to date. We undertook this study to analyze the prevalence of SARS-CoV-2 in human post-mortem ocular tissues. Methods: The expression of SARS-CoV-2 RNA was assessed by RT-PCR in corneal and scleral tissues from 33 surgical-intended donors who were eliminated from a surgical use per Eye Bank Association of America (EBAA) donor screening guidelines or medical director review or positive COVID-19 test. Ocular levels of SARS-CoV-2 RNA (RT-PCR), Envelope and Spike proteins (immunohistochemistry) and anti-SARS-CoV-2 IgG and IgM antibodies (ELISA) in blood were evaluated in 10 COVID-19 donors. Findings: Of 132 ocular tissues from 33 surgical-intended donors, the positivity rate for SARS-CoV-2 RNA was ~13% (17/132). Of 10 COVID-19 donors, six had PCR positive post-mortem nasopharyngeal swabs whereas eight exhibited positive post-mortem anti-SARS-CoV-2 IgG levels. Among 20 eyes recovered from 10 COVID-19 donors: three conjunctival, one anterior corneal, five posterior corneal, and three vitreous swabs tested positive for SARS-CoV-2 RNA. SARS-CoV-2 spike and envelope proteins were detected in epithelial layer of the corneas that were procured without Povidone-Iodine (PVP-I) disinfection. Interpretations: Our study showed a small but noteworthy prevalence of SARS-CoV-2 in ocular tissues from COVID-19 donors. These findings underscore the criticality of donor screening guidelines, post-mortem nasopharyngeal PCR testing and PVP-I disinfection protocol to eliminate any tissue harboring SARS-CoV-2 being used for corneal transplantation.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by research grants from the Eye Bank Association of America and National Eye Institute (AK EY027381 EY026964) and National Institute of Allergy and Infectious Diseases (AK AI135583 AI140033).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was performed in compliance with the Declaration of Helsinki and Eye Bank Association of America (EBAA) and Food and Drug Administration (FDA) regulations. Consent for research was obtained prior to procurement from each donor family. The University of Michigan medical school institutional review board (IRBMED) determined that this study does not fit the definition of human subjects research requiring IRB approval. Laboratory experiments from this study were approved by the Institutional Biosafety Committee (IBC) at the Wayne State University (IBC# 20-04-2164). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesWe (investigators) have access to all the data represented in this manuscript.
AU  - Sawant, Onkar B.
AU  - Singh, Sneha
AU  - Wright, Robert Emery
AU  - Jones, Kayla M.
AU  - Titus, Michael S.
AU  - Dennis, Eugene
AU  - Hicks, Eric
AU  - Majmudar, Parag A.
AU  - Kumar, Ashok
AU  - Mian, Shahzad I.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20201574
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20201574
ST  - Prevalence of SARS-CoV-2 in human post-mortem ocular tissues (preprint)
T2  - medRxiv
TI  - Prevalence of SARS-CoV-2 in human post-mortem ocular tissues (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20201574.abstract
ID  - 7794733
ER  - 

TY  - JOUR
AB  - Diagnosis of SARS-COV-2 infection (COVID-19) is currently based on detection of the viral RNA in nasopharyngeal swab samples by reverse transcription polymerase chain reaction (RT-PCR). However, sampling via nasopharyngeal swabs frequently provokes sneezing or coughing, which results in increased risk of the viral dissemination and environmental contamination. Furthermore, the sensitivity associated with the PCR tests s limited to 60%-70%, which is mainly attributable to technical deficiency in sampling. Given that the disease is transmitted via exhaled aerosol and droplets, and that the exhaled breath condensate (EBC) is the established modality for sampling exhaled aerosol, detection of the viral RNA in EBC is a promising approach for safe and efficient diagnosis of the disease. Subjects are those patients who are diagnosed with COVID-19 by positive nasopharyngeal swab PCR test and admitted to Saitama Medical Center, Japan. EBC samples will be collected using an R-tube(�]) or R-tubeVent(�]) device. Collected EBC samples will be introduced into a nucleic acid purifier. The purified nucleic acids will undergo amplification through RT-PCR for detection and quantification of SARS-COV-2 RNA. To date we have collected eight samples from seven subjects. Among them, two samples from two subjects tested positive for SARS-COV-2 RNA by the RT-PCR. Reflecting the second wave of COVID-19 prevalence in Japan, new admissions of COVID-19 patients to the Saitama Medical Center are increasing, and we are expecting to collect at least 50 EBC samples from 25 patients before the end of this year.
AD  - Center for Advanced Emergency Medicine and Critical Care, Saitama Medical Center, Kawagoe, Japan.
AN  - 33021206
AU  - Sawano, M.
AU  - Takeshita, K.
AU  - Ohno, H.
AU  - Oka, H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1088/1752-7163/abb99b
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Journal of breath research
LA  - eng
N1  - 1752-7163
Sawano, Makoto
Takeshita, Kyousuke
Ohno, Hideaki
Oka, Hideaki
Journal Article
England
J Breath Res. 2020 Oct 6;14(4):042003. doi: 10.1088/1752-7163/abb99b.
PY  - 2020
SN  - 1752-7155
SP  - 042003
ST  - A short perspective on a COVID-19 clinical study: 'diagnosis of COVID-19 by RT-PCR using exhale breath condensate samples'
T2  - Journal of breath research
TI  - A short perspective on a COVID-19 clinical study: 'diagnosis of COVID-19 by RT-PCR using exhale breath condensate samples'
VL  - 14
ID  - 7791042
ER  - 

TY  - JOUR
AU  - Sawada, Morio
AU  - Waratani, Miyoko
AU  - Fujiwara, Yoichiro
AU  - Okubo, Tomoharu
AU  - Kondoh, Eiji
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Prevalence of SARS-CoV-2 among pregnant women in Kyoto, Japan: Is universal screening for SARS-CoV-2 before delivery necessary?
T2  - Hypertension Research in Pregnancy
TI  - Prevalence of SARS-CoV-2 among pregnant women in Kyoto, Japan: Is universal screening for SARS-CoV-2 before delivery necessary?
UR  - https://doi.org/10.14390/jsshp.HRP2020-015
ID  - 7792721
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic represents a worldwide threat to mental health. To optimize the allocation of health care resources, research on specific vulnerability factors, such as health anxiety, intolerance of uncertainty, and distress (in)tolerance, and particularly their effect on the time course of SARS-CoV-2 related anxiety appears crucial for supporting high risk groups suffering from elevated mental distress during the pandemic. N = 887 participants (78.4% female; M(age) = 38.15, SD = 17.04) completed an online survey in Germany (April to mid-May 2020), comprising measures of SARS-CoV-2 related anxiety, health anxiety, safety and preventive behavior, intolerance of uncertainty, and distress intolerance. Higher levels of health anxiety pre and during COVID-19 were associated with an initially intensified increase (b = 1.10, p  0.001), but later on a more rapid dampening (b = -0.18, p  0.001) of SARS-CoV-2 related anxiety. SARS-CoV-2 related preventive behavior was intensified by both pre (b = 0.06, p = 0.01) and during (b = 0.15, p  0.001) COVID-19 health anxiety, while reassurance behavior only was associated with health anxiety during COVID-19 (b = 0.14, p  0.001). Distress intolerance and intolerance of uncertainty did not moderate the relationship between health anxiety and SARS-CoV-2 related anxiety and behavior. The results suggest detrimental effects of health anxiety on the emotional and behavioral response to virus outbreaks.
AD  - Department of Clinical Psychology, Psychotherapy, and Experimental Psychopathology, Johannes Gutenberg-University of Mainz, Wallstraße 3, 55122 Mainz, Germany.
AN  - 33022993
AU  - Sauer, K. S.
AU  - Jungmann, S. M.
AU  - Witthöft, M.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/ijerph17197241
DP  - NLM
ET  - 2020/10/08
IS  - 19
J2  - International journal of environmental research and public health
KW  - Covid-19
distress tolerance
health anxiety
intolerance of uncertainty
safety behaviors
virus anxiety
LA  - eng
N1  - 1660-4601
Sauer, Karoline S
Jungmann, Stefanie M
Witthöft, Michael
Orcid: 0000-0002-4928-4222
Journal Article
Switzerland
Int J Environ Res Public Health. 2020 Oct 3;17(19):E7241. doi: 10.3390/ijerph17197241.
PY  - 2020
SN  - 1660-4601
ST  - Emotional and Behavioral Consequences of the COVID-19 Pandemic: The Role of Health Anxiety, Intolerance of Uncertainty, and Distress (In)Tolerance
T2  - International journal of environmental research and public health
TI  - Emotional and Behavioral Consequences of the COVID-19 Pandemic: The Role of Health Anxiety, Intolerance of Uncertainty, and Distress (In)Tolerance
VL  - 17
ID  - 7790931
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The rapid emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in an increased mortality rate across the globe. However, the underlying mechanism of SARS-CoV-2 altering human immune response is still elusive. The existing literature on miRNA mediated pathogenesis of RNA virus viz. Dengue virus, West Nile virus, etc. raises a suspicion that miRNA encoded by SARS-CoV-2 might facilitate virus replication and regulate the host's gene expression at the post-transcriptional level. METHODS: We investigated this possibility via computational prediction of putative miRNAs encoded by the SARS-CoV-2 genome using a novel systematic pipeline that predicts putative mature-miRNA and their targeted genes transcripts. To trace down if viral-miRNAs targeted the genes critical to the immune pathway, we assessed whether mature miRNA transcripts exhibit effective hybridization with the 3'UTR region of human gene transcripts. Conversely, we also tried to study human miRNA-mediated viral gene regulation to get insight into the miRNA mediated offense and defense mechanism of viruses and their host organisms in too. RESULTS: Our analysis led us to shortlist six putative miRNAs that target, majorly, genes related to cell proliferation/differentiation/signaling, and senescence. Nonetheless, they also target immune-related genes that directly/indirectly orchestrate immune pathways like TNF (Tumor Necrosis Factor) signaling and Chemokine signaling pathways putatively serving as the nucleus to cytokine storms. CONCLUSION: Besides, these six miRNAs were found to conserved so far across 80 complete genomes of SARS-CoV-2 (NCBI Virus, last assessed 12 April 2020) including Indian strains that are also targeted by 7 human miRNAs and can, therefore, be exploited to develop MicroRNA-Attenuated Vaccines.
AD  - Department of Biotechnology, Noida Institute of Engineering and Technology (NIET), Greater Noida,. India.
Institute of Clinical Medicine, University of Eastern Finland, Kuopio,. Finland.
Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida,. India.
Department of Applied Physics, Aalto University, Espoo,. Finland.
Novel Global Community Educational Foundation,. Australia.
AN  - 33023438
AU  - Satyam, R.
AU  - Bhardwaj, T.
AU  - Goel, S.
AU  - Jha, N. K.
AU  - Jha, S. K.
AU  - Nand, P.
AU  - Ruokolainen, J.
AU  - Kamal, M. A.
AU  - Kesari, K. K.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.2174/1381612826999201001200529
DP  - NLM
ET  - 2020/10/08
J2  - Current pharmaceutical design
KW  - Cytokine storm
Functional annotation
SARS-CoV-2
pathway analysis
systems biology
targetome
LA  - eng
N1  - 1873-4286
Satyam, Rohit
Bhardwaj, Tulika
Goel, Sachin
Jha, Niraj Kumar
Jha, Saurabh Kumar
Nand, Parma
Ruokolainen, Janne
Kamal, Mohammad Amjad
Kesari, Kavindra Kumar
Journal Article
United Arab Emirates
Curr Pharm Des. 2020 Oct 1. doi: 10.2174/1381612826999201001200529.
PY  - 2020
SN  - 1381-6128
ST  - miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis
T2  - Current pharmaceutical design
TI  - miRNAs in SARS-CoV 2: A Spoke in the Wheel of Pathogenesis
ID  - 7790911
ER  - 

TY  - JOUR
AU  - Satyam, Abhigyan
AU  - Tsokos, George C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Curb the complement to cure COVID
T2  - Clinical Immunology
TI  - Curb the complement to cure COVID
UR  - https://doi.org/10.1016/j.clim.2020.108603
ID  - 7793204
ER  - 

TY  - JOUR
AB  - Aim The coronavirus disease 2019 (COVID-19) pandemic has created significant challenges to healthcare globally, necessitating rapid restructuring of service provision. This questionnaire survey was conducted amongst adult heart failure (HF) patients in the United Kingdom (UK), to understand the impact of COVID-19 upon HF services. Methods and Results The survey was conducted by the Pumping Marvellous Foundation (PMF), a UK HF patient charity. Survey Monkey was used to disseminate the questionnaire in the PMF online patient group and in 10 UK hospitals (out-patient hospital and community HF clinics). 1050 responses were collected (693/1050-66% women); 55% (579/1050) were aged over 60 years. Anxiety level was significantly higher regarding COVID19 (mean 7+/-2.5 on anxiety scale of 0 to 10) compared to anxiety regarding HF (6.1+/-2.4; p&amp;lt;0.001). Anxiety was higher amongst patients aged &amp;lt;/=60 years about HF (6.3+/-2.2 versus 5.9+/-2.5 in those aged &amp;gt;60 years; p=0.005) and COVID-19 (7.3+/-2.3 versus 6.7+/-2.6 those aged &amp;gt;60 years; p&amp;lt;0.001). 65% respondents (686/1050) reported disruption to HF appointments (cancellation or postponement) during the lockdown period. 37% reported disruption to medication prescription services and 34% reported inability to access their HF teams promptly. 32% expressed reluctance to attend hospital (25% stated they would only attend hospital if there was no alternative and 7% stated that they would not attend hospital at all). Conclusions The COVID-19 pandemic has caused significant anxiety amongst HF patients regarding COVID-19 and HF. Cancellation or postponement of scheduled clinic appointments, investigations, procedures, prescription and monitoring services were implicated as sources of anxiety.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding was receivedAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:All necessary ethical guidelines have been followed. Institutional ethics approval obtained from the advisory board of the Patient-Led Charity Pumping Marvellous Foundation and the audit and research department at Liverpool University Hospitals NHS Foundation TrustAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesRaw data were generated at the Pumping Marvellous Foundation by analysis of data from https://www.surveymonkey.co.uk/r/K2DSBPZ. Derived data supporting the findings of this study are available from the corresponding author [RS] on requesthttps://www.surveymonkey.co.uk/r/K2DSBPZ
AU  - Sankaranarayanan, Rajiv
AU  - Hartshorne-Evans, Nick
AU  - Redmond-Lyon, Sam
AU  - Wilson, Jill
AU  - Essa, Hani
AU  - Gray, Alastair
AU  - Clayton, Louise
AU  - Barton, Carys
AU  - Ahmed, Fozia Z.
AU  - Cunnington, Colin
AU  - Satchithananda, Duwarakan
AU  - Murphy, Clare
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20205328
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20205328
ST  - The Impact of COVID-19 on the Management of Heart Failure -A United Kingdom Patient Questionnaire Study (preprint)
T2  - medRxiv
TI  - The Impact of COVID-19 on the Management of Heart Failure -A United Kingdom Patient Questionnaire Study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20205328.abstract
ID  - 7794772
ER  - 

TY  - JOUR
AU  - Sanchez, Julian
AU  - Feeney, Matthew
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - public health, GPS data, cell data, decentralized data retention methods, pandemic, epidemic, COVID-19, coronavirus, PII, Personally Identifiable Information, government benefits, lawmakers, federal support
PY  - 2020
ST  - Protect Privacy When Contact Tracing (preprint)
T2  - SSRN
TI  - Protect Privacy When Contact Tracing (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3694685
ID  - 7794788
ER  - 

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVE: Very low birthweight (VLBW) infants are highly susceptible to respiratory infections. Information about prevalence of viral respiratory infections (VRIs) in neonatal intensive care unit (NICU) is scarce. Recent evidence suggests short-term and long-term impact of VRI in morbidity of VLBW infants. The goal of this study is to conduct a VRI surveillance in VLBW infants during NICU admission to address the prevalence, type of viruses and associated clinical features. METHODS: Prospective observational cohort study on infants below 32 gestational weeks admitted to a tertiary NICU during a 2-year period. Respiratory virus detection (influenza, parainfluenza, rhinovirus (hRV), enterovirus, respiratory syncytial virus, metapneumovirus, coronavirus, bocavirus and adenovirus) was performed by real time multiplex PCR assays in nasopharyngeal aspirates (NPAs), within the first 72 hours after birth and weekly, until discharge. Additional samples were taken if clinically indicated. RESULTS: 147 out of 224 eligible infants were enrolled. At least one positive NPA was found in 38% of the study cohort. Main viruses identified were hRV (58%) and adenovirus (31%). Among the 56 infants with positive NPA, 26 showed non-specific respiratory features in 58% (increased respiratory workload, tachypnoea, apnoea) or typical cold features in 38% (rhinorrhea, cough, fever), at least in one episode. Antibiotics were prescribed in 29% of cases. Positive infants showed higher rates of bronchopulmonary dysplasia (BPD), need for supplemental oxygen and mechanical ventilation, and had longer hospital stay. Cox regression analysis found BPD as an independent risk factor for viral infection (p0.001) and symptomatic VRI (p0.04). CONCLUSIONS: Systematic surveillance in VLBW infants reports VRI is frequent, particularly by hRV. Asymptomatic infection is highly prevalent which is critical in the face of establishing appropriate preventive strategies. Infants with BPD are especially vulnerable to such infections.
AD  - Neonatology Department, IdiPaz Foundation, La Paz University Hospital, Madrid, Spain.
Pediatric Infectious Diseases Department, IdiPaz Foundation, La Paz University Hospital, Madrid, Spain.
Respiratory Virus and Influenza Unit, National Center of Microbiology, Madrid, Spain.
AN  - 33024832
AU  - S֙nchez Garc�Ta, L.
AU  - Calvo, C.
AU  - Casas, I.
AU  - Pozo, F.
AU  - Pellicer, A.
C1  - 10/7/2020
C2  - PMC7513636
DB  - PubMed
DO  - 10.1136/bmjpo-2020-000661
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMJ paediatrics open
KW  - infectious diseases
neonatology
respiratory
virology
LA  - eng
N1  - 2399-9772
S֙nchez Garc�Ta, Laura
Orcid: 0000-0001-7416-3951
Calvo, Cristina
Casas, Inmaculada
Pozo, Francisco
Pellicer, Adelina
Journal Article
England
BMJ Paediatr Open. 2020 Sep 22;4(1):e000661. doi: 10.1136/bmjpo-2020-000661. eCollection 2020.
PY  - 2020
SN  - 2399-9772
SP  - e000661
ST  - Viral respiratory infections in very low birthweight infants at neonatal intensive care unit: prospective observational study
T2  - BMJ paediatrics open
TI  - Viral respiratory infections in very low birthweight infants at neonatal intensive care unit: prospective observational study
VL  - 4
ID  - 7790765
ER  - 

TY  - JOUR
AD  - Emergency Physician, Dandenong Hospital, Monash Health, VIC, Australia.
Adjunct Lecturer, School of clinical science, Monash University, VIC, Australia.
Emergency Physician and Director, Dandenong Hospital, Monash Health, VIC, Australia.
AN  - 33025672
AU  - Sam, K. M.
AU  - Soden, F.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/1742-6723.13662
DP  - NLM
ET  - 2020/10/08
J2  - Emergency medicine Australasia : EMA
LA  - eng
N1  - 1742-6723
Sam, Khin Moe
Orcid: 0000-0001-8029-2506
Soden, Frank
Letter
Australia
Emerg Med Australas. 2020 Oct 6. doi: 10.1111/1742-6723.13662.
PY  - 2020
SN  - 1742-6723
ST  - Delivering effective mortality and morbidity meetings in a Victorian urban district Emergency Department under COVID-19 restrictions - a futuristic approach?
T2  - Emergency medicine Australasia : EMA
TI  - Delivering effective mortality and morbidity meetings in a Victorian urban district Emergency Department under COVID-19 restrictions - a futuristic approach?
ID  - 7790688
ER  - 

TY  - JOUR
AU  - Salum, Giovanni A.
AU  - Spanemberg, Lucas
AU  - Hartmann de Souza, L�Tvia Harzheim
AU  - Erno, Teixeira
AU  - Danielle, S.
AU  - Simioni, André R.
AU  - Motta, Luis Souza
AU  - Kristensen, Christian H.
AU  - de Abreu Costa, Marianna
AU  - Pio de Almeida Fleck, Marcelo
AU  - Manfro, Gisele G.
AU  - Dreher, Carolina Blaya
AU  - Teodoro, Maria Dilma
AU  - Marques, Maximiliano das Chagas
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Letter to the Editor: Training Mental Health Professionals to provide support in Brief Telepsychotherapy and Telepsychiatry for Health Workers in the SARS-CoV-2 Pandemic
T2  - Journal of Psychiatric Research
TI  - Letter to the Editor: Training Mental Health Professionals to provide support in Brief Telepsychotherapy and Telepsychiatry for Health Workers in the SARS-CoV-2 Pandemic
UR  - https://doi.org/10.1016/j.jpsychires.2020.09.036
ID  - 7793120
ER  - 

TY  - JOUR
AB  - The global COVID-19 pandemic is causing unprecedented job loss and financial strain. It is unclear how those most directly experiencing economic impacts may seek assistance from disparate safety net programs. To identify self-reported economic hardship and enrollment in major safety net programs before and early in the COVID-19 pandemic, we compared individuals with COVID-19 related employment or earnings reduction with other individuals. We created a set of questions related to COVID-19 economic impact that was added to a cross-sectional, nationally representative online survey of American adults (age �?8, English-speaking) in the AmeriSpeak panel fielded from April 23-27, 2020. All analyses were weighted to account for survey non-response and known oversampling probabilities. We calculated unadjusted bivariate differences, comparing people with and without COVID-19 employment and earnings reductions with other individuals. Our study looked primarily at awareness and enrollment in seven major safety net programs before and since the pandemic (Medicaid, health insurance marketplaces/exchanges, unemployment insurance, food pantries/free meals, housing/renters assistance, SNAP, and TANF). Overall, 28.1% of all individuals experienced an employment reduction (job loss or reduced earnings). Prior to the pandemic, 39.0% of the sample was enrolled in �? safety net program, and 50.0% of individuals who subsequently experienced COVID-19 employment reduction were enrolled in at least one safety net program. Those who experienced COVID-19 employment reduction versus those who did not were significantly more likely to have applied or enrolled in �? program (45.9% versus 11.7%, p0.001) and also significantly more likely to specifically have enrolled in unemployment insurance (29.4% versus 5.4%, p  .001) and SNAP (16.8% versus 2.8%, p = 0.028). The economic devastation from COVID-19 increases the importance of a robust safety net.
AD  - Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America.
Division of Health Policy and Management, University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America.
State Health Access Data Assistance Center (SHADAC), University of Minnesota School of Public Health, Minneapolis, Minnesota, United States of America.
AN  - 33022013
AU  - Saloner, B.
AU  - Gollust, S. E.
AU  - Planalp, C.
AU  - Blewett, L. A.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240080
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Saloner, Brendan
Gollust, Sarah E
Planalp, Colin
Blewett, Lynn A
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0240080. doi: 10.1371/journal.pone.0240080. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240080
ST  - Access and enrollment in safety net programs in the wake of COVID-19: A national cross-sectional survey
T2  - PloS one
TI  - Access and enrollment in safety net programs in the wake of COVID-19: A national cross-sectional survey
VL  - 15
ID  - 7790991
ER  - 

TY  - JOUR
AB  - Efficient therapeutic strategies are needed to counter the COVID-19 pandemic, caused by the SARS-CoV-2 virus. In a context where specific vaccines are not yet available, the containment of the pandemic would be facilitated with efficient prophylaxis. We screened several clinical trials repositories and platforms in search of the prophylactic strategies being investigated against COVID-19 in July 2020. Up to July 5, 2020, only one clinical trial result was published, although we found 112 clinical trial protocols targeting medical workers (n=70, 63%), patients relatives (n=20, 18%) or individuals at risk of severe COVID-19 (n=14, 13%). (Hydroxy)chloroquine was the most frequently evaluated treatment (n=69, 62%), before BCG vaccine (n=12, 11%), this followed by numerous antivirals and immune enhancers. Ninety-eight (88%) clinical trials were randomized with a median of planned inclusions of 530 (IQR 258-1299). Both pre- and post-exposure prophylaxes are investigated.
AD  - École Normale Supérieure de Paris, 45 Rue D'Ulm, 75005 Paris, France; Department of Human Medicine, Faculty of Health, Witten-Herdecke University, 58453 Witten, Germany. Electronic address: erwan.sallard@ens.psl.eu.
Université de Paris, IAME, INSERM, F-75018 Paris, France.
Université de Paris, IAME, INSERM, F-75018 Paris, France; Assistance Publique - Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, 75018 Paris, France.
Université de Paris, IAME, INSERM, F-75018 Paris, France; Assistance Publique - Hôpitaux de Paris, Bichat-Claude Bernard University Hospital, 75018 Paris, France; National Institute for Health Research Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Imperial College London, London, UK.
AN  - 33022293
AU  - Sallard, E.
AU  - Belhadi, D.
AU  - Lescure, F. X.
AU  - Yazdanpanah, Y.
AU  - Peiffer-Smadja, N.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.medmal.2020.09.013
DP  - NLM
ET  - 2020/10/07
J2  - Medecine et maladies infectieuses
KW  - Covid-19
SARS-CoV-2
prophylaxis
repurposed chemotherapy
LA  - eng
N1  - 1769-6690
Sallard, Erwan
Belhadi, Drifa
Lescure, François-Xavier
Yazdanpanah, Yazdan
Peiffer-Smadja, Nathan
Journal Article
Review
France
Med Mal Infect. 2020 Oct 3:S0399-077X(20)30711-3. doi: 10.1016/j.medmal.2020.09.013.
PY  - 2020
SN  - 0399-077x
ST  - Clinical trial protocols of repurposed prophylaxis for COVID-19: a review
T2  - Medecine et maladies infectieuses
TI  - Clinical trial protocols of repurposed prophylaxis for COVID-19: a review
ID  - 7790968
ER  - 

TY  - JOUR
AB  - Prompt identification of the clinical status and severity of COVID-19 can be a challenge in the emergency department (ED), as the clinical severity of the disease is variable, real-time reverse-transcription PCR (RT-PCR) results may not be immediately available, and imaging findings appear approximately 10 days after the onset of symptoms. There is currently no set of simple, readily available and fast battery of tests that can be used in the ED as prognostic factors. The purpose was to study laboratory test results in patients with COVID-19 at hospital emergency admission and to evaluate the results in non-survivors and their potential prognostic value. A profile of laboratory markers was agreed with the ED providers based on the International Federation of Clinical Chemistry and Laboratory Medicine recommendation of its usefulness, which was made in 218 patients with COVID-19. Non-survivors were significantly older, and the percentage of patients with pathological values of creatinine, albumin, lactate dehydrogenase (LDH), C reactive protein, prothrombin time, D-dimer, and arterial blood gas, PaO(2)/FIO(2) and satO2/FIO(2) indices were significantly higher among the patients with COVID-19 who died than those who survived. Patients who died also presented higher neutrophil counts. Among all studied tests, albumin and LDH were independent prognostic factors for death. The results of the study show pathology in nine laboratory markers in patients with COVID-19 admitted in the ED, valuable findings to take into consideration for its prompt identification when there is no immediate availability of RT-PCR results.
AD  - Clinical Laboratory, Hospital Universitari San Juan de Alicante, Sant Joan d'Alacant, Spain salinas_mar@gva.es.
Department of Biochemistry and Molecular Pathology, Faculty of Medicine, Miguel Hernandez University of Elche, Sant Joan D'Alacant, Spain.
Clinical Laboratory, Hospital Universitari San Juan de Alicante, Sant Joan d'Alacant, Spain.
Department of Clinical Medicine, Faculty of Medicine, Miguel Hernandez University of Elche, Sant Joan D'Alacant, Spain.
Radiology Department, University of Missouri Columbia Health Care, Columbia, Missouri, USA.
AN  - 33023942
AU  - Salinas, M.
AU  - Blasco, Á
AU  - Santo-Quiles, A.
AU  - Lopez-Garrigos, M.
AU  - Flores, E.
AU  - Leiva-Salinas, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/jclinpath-2020-206865
DP  - NLM
ET  - 2020/10/08
J2  - Journal of clinical pathology
KW  - blood proteins
chemistry
clinical
diagnostic techniques and procedures
infections
medical laboratory science
LA  - eng
N1  - 1472-4146
Salinas, Maria
Orcid: 0000-0003-3420-5509
Blasco, Álvaro
Santo-Quiles, Ana
Lopez-Garrigos, Maite
Flores, Emilio
Leiva-Salinas, Carlos
Journal Article
England
J Clin Pathol. 2020 Oct 6:jclinpath-2020-206865. doi: 10.1136/jclinpath-2020-206865.
PY  - 2020
SN  - 0021-9746
ST  - Laboratory parameters in patients with COVID-19 on first emergency admission is different in non-survivors: albumin and lactate dehydrogenase as risk factors
T2  - Journal of clinical pathology
TI  - Laboratory parameters in patients with COVID-19 on first emergency admission is different in non-survivors: albumin and lactate dehydrogenase as risk factors
ID  - 7790859
ER  - 

TY  - JOUR
AB  - The emergence of a new coronavirus, in around late December 2019 which had first been reported in Wuhan, China has now developed into a massive threat to global public health. The World Health Organization (WHO) has named the disease caused by the virus as COVID-19 and the virus which is the culprit was renamed from the initial novel respiratory 2019 coronavirus to SARS-CoV-2. The person-to-person transmission of this virus is ongoing despite drastic public health mitigation measures such as social distancing and movement restrictions implemented in most countries. Understanding the source of such an infectious pathogen is crucial to develop a means of avoiding transmission and further to develop therapeutic drugs and vaccines. To identify the etiological source of a novel human pathogen is a dynamic process that needs comprehensive and extensive scientific validations, such as observed in the Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and human immunodeficiency virus (HIV) cases. In this context, this review is devoted to understanding the taxonomic characteristics of SARS-CoV-2 and HIV. Herein, we discuss the emergence and molecular mechanisms of both viral infections. Nevertheless, no vaccine or therapeutic drug is yet to be approved for the treatment of SARS-CoV-2, although it is highly likely that new effective medications that target the virus specifically will take years to establish. Therefore, this review reflects the latest repurpose of existing antiviral therapeutic drug choices available to combat SARS-CoV-2.
AN  - PMC7536551
AU  - Saleemi, Mansab Ali
AU  - Ahmad, Bilal
AU  - Benchoula, Khaled
AU  - Vohra, Muhammad Sufyan
AU  - Mea, Hing Jian
AU  - Chong, Pei Pei
AU  - Palanisamy, Navindra Kumari
AU  - Wong, Eng Hwa
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.meegid.2020.104583
DP  - NLM
J2  - Infect Genet Evol
KW  - COVID-19
HIV
Origin and taxonomy
Molecular mechanisms
Potential therapeutics
LA  - eng
N1  - PMC7536551[pmcid]
S1567-1348(20)30414-7[PII]
PY  - 2020
SN  - 1567-1348
1567-7257
SP  - 104583
ST  - Emergence and molecular mechanisms of SARS-CoV-2 and HIV to target host cells and potential therapeutics
T2  - Infection, Genetics and Evolution
TI  - Emergence and molecular mechanisms of SARS-CoV-2 and HIV to target host cells and potential therapeutics
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536551/
ID  - 7790670
ER  - 

TY  - JOUR
AB  - In the last months, a rapidly increasing number of people have been infected with severe acute respiratory syndrome coronavirus 2, the virus causing coronavirus disease 2019 (COVID-19). Due to the risk of cross-infections, the number of visits and injections was dramatically reduced in the last months, and the time between visits has been rescheduled from every 15 to 45 min, significantly impairing the total number of available visits. Although continuity of care has been allowed, a series of measures to diminish the risk of contamination need to be adopted until the end of this pandemic outbreak, which may persist until the development of an effective vaccine. For these reasons, we have introduced a new treatment regimen that is aimed at reducing the number of in-person visits and achieving continuity of treatment. This regimen is named "Triple and Plan" (TriPla). The main advantage of the TriPla regimen is to reduce the number of visits of patients in comparison to the pro re nata and treat and extend regimen. Using the TriPla regimen, the risk of contamination would be reduced. Furthermore, by reducing the number of scheduled visits, physicians could guarantee an adequate number of examinations for each patient, lengthening the interval between visits, and reducing the risk of cross-infections.
AD  - School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Division of head and neck, Ophthalmology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Ophthalmology, Department of Surgical, Medical, Molecular Pathology and of Critical Area, University of Pisa, Pisa, Italy.
AN  - 33023326
AU  - Sacconi, R.
AU  - Borrelli, E.
AU  - Vella, G.
AU  - Querques, L.
AU  - Prascina, F.
AU  - Zucchiatti, I.
AU  - Bandello, F.
AU  - Querques, G.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1177/1120672120963448
DP  - NLM
ET  - 2020/10/08
J2  - European journal of ophthalmology
KW  - Retina
age-related macular degeneration
retina - medical therapies
retinal pathology/research
techniques of retinal examination
LA  - eng
N1  - 1724-6016
Sacconi, Riccardo
Borrelli, Enrico
Vella, Giovanna
Querques, Lea
Prascina, Francesco
Orcid: 0000-0003-3238-9682
Zucchiatti, Ilaria
Bandello, Francesco
Querques, Giuseppe
Orcid: 0000-0002-3292-9581
Editorial
United States
Eur J Ophthalmol. 2020 Oct 7:1120672120963448. doi: 10.1177/1120672120963448.
PY  - 2020
SN  - 1120-6721
SP  - 1120672120963448
ST  - TriPla Regimen: A new treatment approach for patients with neovascular age-related macular degeneration in the COVID-19 "era"
T2  - European journal of ophthalmology
TI  - TriPla Regimen: A new treatment approach for patients with neovascular age-related macular degeneration in the COVID-19 "era"
ID  - 7790921
ER  - 

TY  - JOUR
AB  - Background: Understanding people, physicians, and healthcare workers&#039; knowledge, attitude, and practices (KAPs) can help to achieve the outcomes of planned behavior. The aim of this study was to investigate and synthesize the current evidence on KAPs regarding COVID-19. Methods: We conducted a systematic search on PubMed/LitCovid, Scopus, and Web of Sciences databases for papers in the English language only, up to 1 Jul 2020. We used the Joanna Briggs Institute (JBI) checklist developed for cross-sectional studies to appraise the quality of the included studies. All stages of the review conducted by two independent reviewers and potential discrepancies solved with a consultation with a third reviewer. We reported the result as number and percentage. PROSPERO registration code: (CRD42020186755). Results: Fifty-two studies encompassing 49786 participants were included in this review. 45.76% of the participants were male. The mean age of the participants was 32.6 years. 44.2% of the included studies were scored as good quality, 46.2% as fair quality, and remaining (9.6%) as low quality. 30.76% examined all three components of the KAPs model. The knowledge component was reported as good, fair, and poor in 59%, 34%, and 7%, respectively. Of the studies that examined the attitude component, 82% reported a positive attitude, 11% a fairly positive attitude, and 7% a negative attitude. For the practice component, 52% reported good practice, 44% fair practice, and 4% poor practice. Conclusion: This systematic review showed that the overall KAP components in the included studies were at an acceptable level. In general, knowledge was at a good level, the attitude was positive and practice was at a fairly good level. Using an integrated international system can help better evaluate these components and compare them between countries.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNoneAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Our research recived an ethical code from Birjand University of Medical SciencesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll relevant data exist in the manuscript.
AU  - Saadatjoo, Saeede
AU  - Miri, Maryam
AU  - Hassanipour, Soheil
AU  - Ameri, Hosein
AU  - Arab-Zozani, Morteza
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206094
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206094
ST  - A systematic review of the knowledge, attitudes, and practices of physicians, health workers, and the general population about Coronavirus disease 2019 (COVID-19) (preprint)
T2  - medRxiv
TI  - A systematic review of the knowledge, attitudes, and practices of physicians, health workers, and the general population about Coronavirus disease 2019 (COVID-19) (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206094.abstract
ID  - 7794767
ER  - 

TY  - JOUR
AB  - Rationale Prediction of patients at risk for mortality can help triage patients and assist in resource allocation Objectives Develop and evaluate a machine learning-based algorithm which accurately predicts mortality in COVID-19, pneumonia, and mechanically ventilated patients Methods Retrospective study of 53,001 total ICU patients, including 9166 patients with pneumonia and 25,895 mechanically ventilated patients, performed on the MIMIC dataset An additional retrospective analysis was performed on a community hospital dataset containing 114 patients positive for SARS-COV-2 by PCR test The outcome of interest was in-hospital patient mortality Results When trained and tested on the MIMIC dataset, the XGBoost predictor obtained area under the receiver operating characteristic (AUROC) values of 0 82, 0 81, 0 77, and 0 75 for mortality prediction on mechanically ventilated patients at 12-, 24-, 48-, and 72- hour windows, respectively, and AUROCs of 0 87, 0 78, 0 77, and 0 734 for mortality prediction on pneumonia patients at 12-, 24-, 48-, and 72- hour windows, respectively The predictor outperformed the qSOFA, MEWS and CURB-65 risk scores at all prediction windows When tested on the community hospital dataset, the predictor obtained AUROCs of 0 91, 0 90, 0 86, and 0 87 for mortality prediction on COVID-19 patients at 12-, 24-, 48-, and 72- hour windows, respectively, outperforming the qSOFA, MEWS and CURB-65 risk scores at all prediction windows Conclusions This machine learning-based algorithm is a useful predictive tool for anticipating patient mortality at clinically useful, and is capable of accurate mortality prediction for mechanically ventilated patients as well as those diagnosed with pneumonia and COVID-19
AU  - Ryan, Logan
AU  - Lam, Carson
AU  - Mataraso, Samson
AU  - Allen, Angier
AU  - Green-Saxena, Abigail
AU  - Pellegrini, Emily
AU  - Hoffman, Jana
AU  - Barton, Christopher
AU  - McCoy, Andrea
AU  - Das, Ritankar
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Mortality prediction model for the triage of COVID-19, pneumonia, and mechanically ventilated ICU patients: A retrospective study
T2  - Annals of Medicine and Surgery
TI  - Mortality prediction model for the triage of COVID-19, pneumonia, and mechanically ventilated ICU patients: A retrospective study
UR  - https://doi.org/10.1016/j.amsu.2020.09.044
ID  - 7793244
ER  - 

TY  - JOUR
AB  - BACKGROUND: The prevalence of kidney involvement during SARS-CoV-2 infection has been reported to be high. Nevertheless, data are lacking about the determinants of acute kidney injury (AKI) and the combined effect of chronic kidney disease (CKD) and AKI in COVID-19 patients. METHODS: We collected data on patient demographics, comorbidities, chronic medications, vital signs, baseline laboratory test results and in-hospital treatment in patients with COVID-19 consecutively admitted to our Institution. Chronic kidney disease was defined as eGFR �?0 mL/min per 1.73 m(2) or proteinuria at urinalysis within 180 days prior to hospital admission. AKI was defined according to KDIGO criteria. The primary and secondary outcomes were the development of AKI and death. RESULTS: Of 777 patients eligible for the study, acute kidney injury developed in 176 (22.6%). Of these, 79 (45%) showed an acute worsening of a preexisting CKD, and 21 (12%) required kidney replacement therapy. Independent associates of AKI were chronic kidney disease, C-reactive protein (CRP) and ventilation support. Among patients with acute kidney injury, 111 died (63%) and its occurrence increased the risk of death by 60% (HR 1.60 [95% IC 1.21-2.49] p�?�?.002) independently of potential confounding factors including hypertension, preexisting kidney damage, and comorbidities. Patients with AKI showed a significantly higher rate of deaths attributed to bleeding compared to CKD and the whole population (7.5 vs 1.5 vs 3.5%, respectively). CONCLUSION: Awareness of kidney function, both preexisting CKD and development of acute kidney injury, may help to identify those patients at increased risk of death.
AD  - Department of Internal Medicine, Clinica Nefrologica Dialisi e Trapianto, University of Genoa, Hospital Policlinico San Martino, IRCCS, Viale Benedetto XV, 16132, Genoa, Italy.
Department of Health Sciences, Infectious Diseases Clinic, University of Genoa, Hospital Policlinico San Martino-IRCCS, Genoa, Italy.
Department of Internal Medicine, Clinica Nefrologica Dialisi e Trapianto, University of Genoa, Hospital Policlinico San Martino, IRCCS, Viale Benedetto XV, 16132, Genoa, Italy. francesca.viazzi@unige.it.
AN  - 33025516
AU  - Russo, E.
AU  - Esposito, P.
AU  - Taramasso, L.
AU  - Magnasco, L.
AU  - Saio, M.
AU  - Briano, F.
AU  - Russo, C.
AU  - Dettori, S.
AU  - Vena, A.
AU  - Di Biagio, A.
AU  - Garibotto, G.
AU  - Bassetti, M.
AU  - Viazzi, F.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s40620-020-00875-1
DP  - NLM
ET  - 2020/10/08
J2  - Journal of nephrology
KW  - Acute kidney injury
Covid-19
Chronic kidney disease
Mortality
Proteinuria
LA  - eng
N1  - 1724-6059
Russo, Elisa
Esposito, Pasquale
Taramasso, Lucia
Magnasco, Laura
Saio, Michela
Briano, Federica
Russo, Chiara
Dettori, Silvia
Vena, Antonio
Di Biagio, Antonio
Garibotto, Giacomo
Bassetti, Matteo
Viazzi, Francesca
Orcid: 0000-0003-4219-7043
GECOVID working group
Journal Article
Italy
J Nephrol. 2020 Oct 6. doi: 10.1007/s40620-020-00875-1.
PY  - 2020
SN  - 1121-8428
ST  - Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy
T2  - Journal of nephrology
TI  - Kidney disease and all-cause mortality in patients with COVID-19 hospitalized in Genoa, Northern Italy
ID  - 7790699
ER  - 

TY  - JOUR
AU  - Rubaii, Nadia
AU  - Whigham, Kerry
AU  - Appe, Susan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The public administration imperative of applying an atrocity prevention lens to COVID-19 responses: Leveraging the global pandemic for positive structural change and greater social equity
T2  - Administrative Theory & Praxis
TI  - The public administration imperative of applying an atrocity prevention lens to COVID-19 responses: Leveraging the global pandemic for positive structural change and greater social equity
UR  - https://doi.org/10.1080/10841806.2020.1829260
ID  - 7792964
ER  - 

TY  - JOUR
AB  - The pandemic has highlighted the complexity of public health measures and their side effects, the intricacy of the underlying health, social and political phenomena at play as well as their specificity for marginalized minority communities. Based on this experience, this commentary suggests that it would be relevant in the future to develop consultation mechanisms that take into account the entire population, including marginalized minority groups, in order to better inform decision-making processes in times of pandemic. In a context of fluid crisis, any consultation process must take into account the limits of what is possible and mourn the comprehensiveness in favour of repeated iterations of dialogue, mediation and decision-making. This means creating conditions favourable to the consideration of the most vulnerable people and groups' voices by public authorities. In order to prepare for the next crises, it is necessary to develop strong links between public institutions and communities, both of majorities and minorities, in order to define the mechanisms favouring the emergence of truly inclusive public health, taking into account the physical, mental and social health of the population.
AD  - Division de psychiatrie sociale et culturelle, Université McGill, CLSC Parc-Extension, 7085 Hutchison, Bureau 204.2, Montréal, QC, H3N 1Y9, Canada. cecile.rousseau@mcgill.ca.
Center for Refugee Studies, York University, Toronto, Canada.
Sherpa University Institute, Montreal, Canada.
Résidente en psychiatrie (R3), McGill University, Montreal, Canada.
AN  - 33021729
AU  - Rousseau, C.
AU  - Jaimes, A.
AU  - El-Majzoub, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.17269/s41997-020-00422-2
DP  - NLM
ET  - 2020/10/07
J2  - Canadian journal of public health = Revue canadienne de sante publique
KW  - Covid-19
Communities
Minorities
Pandemic
Public safety
LA  - eng
N1  - 1920-7476
Rousseau, Cécile
Orcid: 0000-0002-6533-6774
Jaimes, Annie
El-Majzoub, Salam
Journal Article
Switzerland
Can J Public Health. 2020 Oct 6. doi: 10.17269/s41997-020-00422-2.
PY  - 2020
SN  - 0008-4263
ST  - Pandémie et communautés minoritaires marginalisées : vers une approche inclusive en santé publique?
T2  - Canadian journal of public health = Revue canadienne de sante publique
TI  - Pandémie et communautés minoritaires marginalisées : vers une approche inclusive en santé publique?
ID  - 7791007
ER  - 

TY  - JOUR
AB  - PURPOSE: SARS-COV-2 is a pathogenic agent belonging to the coronavirus family, responsible for the current global world pandemic. Angiotensin-converting enzyme 2 (ACE-2) is the receptor for cellular entry of SARS-CoV-2. ACE-2 is a type I transmembrane metallo-carboxypeptidase involved in the Renin-Angiotensin pathway. By analyzing two independent databases, ACE-2 was identified in several human tissues including the thyroid. Although some cases of COVID-19-related subacute thyroiditis were recently described, direct proof for the expression of the ACE-2 mRNA in thyroid cells is still lacking. Aim of the present study was to investigate by RT-PCR whether the mRNA encoding for ACE-2 is present in human thyroid cells. METHODS: RT-PCR was performed on in vitro ex vivo study on thyroid tissue samples (15 patients undergoing thyroidectomy for benign thyroid nodules) and primary thyroid cell cultures. RESULTS: The ACE-2 mRNA was detected in all surgical thyroid tissue samples (n�?�?5). Compared with two reporter genes (GAPDH: 0.052 ±�?.0026 Cycles(-1); β-actin: 0.044 ±�?.0025 Cycles(-1); ACE-2: 0.035 ±�?.0024 Cycles(-1)), the mean level of transcript expression for ACE-2 mRNA was abundant. The expression of ACE-2 mRNA in follicular cells was confirmed by analyzing primary cultures of thyroid cells, which expressed the ACE-2 mRNA at levels similar to tissues. CONCLUSIONS: The results of the present study demonstrate that the mRNA encoding for the ACE-2 receptor is expressed in thyroid follicular cells, making them a potential target for SARS-COV-2 entry. Future clinical studies in patients with COVID-19 will be required for increase our understanding of the thyroid repercussions of SARS-CoV-2 infection.
AD  - Laboratory for Endocrine Disruptors, Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, PV, Italy.
Department of Internal Medicine and Therapeutics, University of Pavia, Via S. Maugeri 4, 27100, Pavia, PV, Italy.
Unit of Molecular Cardiology, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, Italy.
Department of General and Minimally Invasive Surgery, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, PV, Italy.
Unit of Pathology, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, PV, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, 56124, Pisa, PI, Italy.
Laboratory for Endocrine Disruptors, Unit of Internal Medicine and Endocrinology, Istituti Clinici Scientifici Maugeri IRCCS, 27100, Pavia, PV, Italy. luca.chiovato@icsmaugeri.it.
Department of Internal Medicine and Therapeutics, University of Pavia, Via S. Maugeri 4, 27100, Pavia, PV, Italy. luca.chiovato@icsmaugeri.it.
AN  - 33025553
AU  - Rotondi, M.
AU  - Coperchini, F.
AU  - Ricci, G.
AU  - Denegri, M.
AU  - Croce, L.
AU  - Ngnitejeu, S. T.
AU  - Villani, L.
AU  - Magri, F.
AU  - Latrofa, F.
AU  - Chiovato, L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s40618-020-01436-w
DP  - NLM
ET  - 2020/10/08
J2  - Journal of endocrinological investigation
KW  - Ace-2
Covid-19
Sars-cov-2
Thyrocytes
Thyroid
LA  - eng
N1  - 1720-8386
Rotondi, M
Coperchini, F
Ricci, G
Denegri, M
Croce, L
Ngnitejeu, S T
Villani, L
Magri, F
Latrofa, F
Chiovato, L
Orcid: 0000-0002-9279-9424
Journal Article
Italy
J Endocrinol Invest. 2020 Oct 6. doi: 10.1007/s40618-020-01436-w.
PY  - 2020
SN  - 0391-4097
ST  - Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis
T2  - Journal of endocrinological investigation
TI  - Detection of SARS-COV-2 receptor ACE-2 mRNA in thyroid cells: a clue for COVID-19-related subacute thyroiditis
ID  - 7790694
ER  - 

TY  - JOUR
AB  - COVID-19 is an illness caused by a novel coronavirus that has rapidly escalated into a global pandemic leading to an urgent medical effort to better characterize this disease biologically, clinically and by imaging. In this review, we present the current approach to imaging of COVID-19 pneumonia. We focus on the appropriate utilization of thoracic imaging modalities to guide clinical management. We will also describe radiologic findings that are considered typical, atypical and generally not compatible with of COVID-19 infection. Further, we review imaging examples of COVID-19 imaging mimics, such as organizing pneumonia, eosinophilic pneumonia and other viral infections.
AD  - University of Pennsylvania Perelman School of Medicine, 14640, Radiology, Philadelphia, Pennsylvania, United States; leonid.roshkovan@pennmedicine.upenn.edu.
University of Pennsylvania Perelman School of Medicine, 14640, Radiology, Philadelphia, Pennsylvania, United States.
University of Pennsylvania Perelman School of Medicine, 14640, Emergency Medicine, Philadelphia, Pennsylvania, United States.
University of Pennsylvania Perelman School of Medicine, 14640, Pulmonary, Allergy and Critical Care , Philadelphia, Pennsylvania, United States.
AN  - 33022182
AU  - Roshkovan, L.
AU  - Chatterjee, N.
AU  - Galperin-Aizenberg, M.
AU  - Gupta, N.
AU  - Shah, R.
AU  - Barbosa, E. M., Jr.
AU  - Simpson, S.
AU  - Cook, T.
AU  - Nachiappan, A.
AU  - Knollmann, F.
AU  - Litt, H.
AU  - Desjardins, B.
AU  - Jha, S.
AU  - Panebianco, N.
AU  - Baston, C.
AU  - Thompson, J. C.
AU  - Katz, S. I.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1513/AnnalsATS.202006-600CME
DP  - NLM
ET  - 2020/10/07
J2  - Annals of the American Thoracic Society
LA  - eng
N1  - 2325-6621
Roshkovan, Leonid
Chatterjee, Neil
Galperin-Aizenberg, Maya
Gupta, Narainder
Shah, Rosita
Barbosa, Eduardo Mortani Jr
Simpson, Scott
Cook, Tessa
Nachiappan, Arun
Knollmann, Friedrich
Litt, Harold
Desjardins, Benoit
Jha, Saurabh
Panebianco, Nova
Baston, Cameron
Thompson, Jeffrey C
Katz, Sharyn I
Journal Article
United States
Ann Am Thorac Soc. 2020 Oct 6. doi: 10.1513/AnnalsATS.202006-600CME.
PY  - 2020
SN  - 2325-6621
ST  - The Role of Imaging in the Management of Suspected or Known COVID-19 Pneumonia: A Multidisciplinary Perspective
T2  - Annals of American Thoracic Society
TI  - The Role of Imaging in the Management of Suspected or Known COVID-19 Pneumonia: A Multidisciplinary Perspective
ID  - 7790977
ER  - 

TY  - JOUR
AB  - Earlier this year, Spain took center stage in the emerging health crisis due to the SARS-CoV-2 pandemic On 14 March 2020, a state of alarm was declared to manage this health crisis The contribution of nursing professionals to sustainability of the system during this health crisis has been vital, not only in specialized care but, in a more understated way, in primary care The objective of the present study was to describe the perceptions and lived experiences of primary care nurses during the COVID-19 health emergency A qualitative study taking a phenomenological approach was carried out, triangulating data collected through non-participant observations, eight in-depth interviews, and two discussion groups with community nurses and case managers A total sample of 20 key informants was obtained during the month of May, 2020 The key informants expressed strong positive perceptions of the recognition received from service users and satisfaction when acknowledging that they have been an important source of emotional support Informants identify the importance of their work in sustaining the system, particularly outlining team cohesion and communication, whilst also evaluating the empowering position in which service users and society itself has put them
AU  - Rojas-Ocaña, Mar�Ta Jesús Araujo-Hern֙ndez Miriam
AU  - Romero-Castillo, Roc�To Rom֙n-Mata Silvia San
AU  - Garc�Ta-Navarro, E. Begoña
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Nursing as a Sustainability Factor of the Health System during the COVID-19 Pandemic: A Qualitative Study
T2  - Sustainability
TI  - Nursing as a Sustainability Factor of the Health System during the COVID-19 Pandemic: A Qualitative Study
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813256
ID  - 7793337
ER  - 

TY  - JOUR
AB  - During the Covid19 pandemic there has been much discussion about in-hospital procedures that may generate aerosols. One such procedure, that has led to confusion and concern, is nebulisation of children. In this paper, we discuss the evidence around whether nebulisation procedures generate aerosols, and offer strategies around nebulisation of children with asthma.
AU  - Rodr�Tguez-Mart�Tnez, Carlos E.
AU  - Sinha, Ian P.
AU  - Whittaker, Elizabeth
AU  - Nagakumar, Prasad
AU  - Fernandes, Ricardo M.
C1  - 10/7/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - en
PY  - 2020
SP  - 1-2
ST  - Nebulization procedures for children with unknown viral status during the COVID-19 pandemic
T2  - Journal of Asthma
TI  - Nebulization procedures for children with unknown viral status during the COVID-19 pandemic
UR  - https://dx.doi.org/10.1080/02770903.2020.1827418
ID  - 7793378
ER  - 

TY  - JOUR
AD  - Pediatric Cardiology Department of Puerta del Mar University Hospital, Cadiz, Spain.
Biomedical Research & Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital, University of Cadiz, Spain.
Pediatric Nephrology Department of Puerta del Mar University Hospital, Cadiz, Spain.
AN  - 33021387
AU  - Rodriguez-Gonzalez, M.
AU  - A, A. Perez-Reviriego
AU  - Castellano-Martinez, A.
C1  - 10/7/2020
DA  - Sep
DB  - PubMed
DO  - 10.2217/bmm-2020-0232
DP  - NLM
ET  - 2020/10/07
IS  - 13
J2  - Biomarkers in medicine
KW  - Covid-19
NT-proBNP
cardiac biomarkers
heart failure
myocardial dysfunction
myocardial injury
myocardial strain
pulmonary hypertension
troponin
LA  - eng
N1  - 1752-0371
Rodriguez-Gonzalez, Moises
Orcid: 0000-0002-5587-435x
A Perez-Reviriego, Alvaro
Castellano-Martinez, Ana
Editorial
England
Biomark Med. 2020 Sep;14(13):1183-1187. doi: 10.2217/bmm-2020-0232.
PY  - 2020
SN  - 1752-0363
SP  - 1183-1187
ST  - Current role of cardiac biomarkers in extra-cardiac diseases in children
T2  - Biomarkers in medicine
TI  - Current role of cardiac biomarkers in extra-cardiac diseases in children
VL  - 14
ID  - 7791033
ER  - 

TY  - JOUR
AB  - Understanding how SARS-CoV-2 spreads within the respiratory tract is important to define the parameters controlling the severity of COVID-19. We examined the functional and structural consequences of SARS-CoV-2 infection in a reconstituted human bronchial epithelium model. SARS-CoV-2 replication caused a transient decrease in epithelial barrier function and disruption of tight junctions, though viral particle crossing remained limited. Rather, SARS-CoV-2 replication led to a rapid loss of the ciliary layer, characterized at the ultrastructural level by axoneme loss and misorientation of remaining basal bodies. The motile cilia function was compromised, as measured in a mucociliary clearance assay. Epithelial defense mechanisms, including basal cell mobilization and interferon-lambda induction, ramped up only after the initiation of cilia damage. Analysis of SARS-CoV-2 infection in Syrian hamsters further demonstrated the loss of motile cilia in vivo. This study identifies cilia damage as a pathogenic mechanism that could facilitate SARS-CoV-2 spread to the deeper lung parenchyma.Competing Interest StatementThe authors have declared no competing interest.
AU  - Robinot, Rémy
AU  - Hubert, Mathieu
AU  - Dias de Melo, Guilherme
AU  - Lazarini, Françoise
AU  - Bruel, Timothée
AU  - Smith, Nikaïa
AU  - Levallois, Sylvain
AU  - Larrous, Florence
AU  - Fernandes, Julien
AU  - Gellenoncourt, Stacy
AU  - Rigaud, Stéphane
AU  - Gorgette, Olivier
AU  - Thouvenot, Catherine
AU  - Trébeau, Céline
AU  - Dumenil, Guillaume
AU  - Mallet, Adeline
AU  - Gobaa, Samy
AU  - Etournay, Raphaël
AU  - Lledo, Pierre-Marie
AU  - Lecuit, Marc
AU  - Bourhy, Hervé
AU  - Duffy, Darragh
AU  - Michel, Vincent
AU  - Schwartz, Olivier
AU  - Chakrabarti, Lisa A.
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.328369
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.328369
ST  - SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance (preprint)
T2  - bioRxiv
TI  - SARS-CoV-2 infection damages airway motile cilia and impairs mucociliary clearance (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.328369.abstract
ID  - 7794716
ER  - 

TY  - JOUR
AD  - Anesthesiology and Critical Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
Pathophysiology of Injury-Induced Immunosuppression (Pi3, EA 7426), Université Claude Bernard Lyon 1, Lyon, France.
Health Data Department, Hospices Civils de Lyon, Lyon, France.
Health Services and Performance Research Lab (HeSPeR, EA 7425), Université Claude Bernard Lyon 1, Lyon, France.
Health Data Department, Hospices Civils de Lyon, Lyon, France. antoineduclos@yahoo.fr.
Health Services and Performance Research Lab (HeSPeR, EA 7425), Université Claude Bernard Lyon 1, Lyon, France. antoineduclos@yahoo.fr.
AN  - 33021683
AU  - Rimmelé, T.
AU  - Pascal, L.
AU  - Polazzi, S.
AU  - Duclos, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00134-020-06249-2
DP  - NLM
ET  - 2020/10/07
J2  - Intensive care medicine
LA  - eng
N1  - 1432-1238
Rimmelé, Thomas
Pascal, Léa
Polazzi, Stéphanie
Duclos, Antoine
Orcid: 0000-0002-8915-4203
Letter
United States
Intensive Care Med. 2020 Oct 6. doi: 10.1007/s00134-020-06249-2.
PY  - 2020
SN  - 0342-4642
ST  - Organizational aspects of care associated with mortality in critically ill COVID-19 patients
T2  - Intensive care medicine
TI  - Organizational aspects of care associated with mortality in critically ill COVID-19 patients
ID  - 7791013
ER  - 

TY  - JOUR
AB  - Decisions about the initiation, continuation and termination of life-supporting treatments are a permanent challenge in intensive care units (ICUs). Decisions should be based on patient preferences and the medical indication. The medical indication is mainly the result of an assessment of the patient's prognosis and the applicable therapeutic options. Factors influencing the short term prognosis are mostly the severity of the acute leading disease, the number and severity of other organ failures and the response to initial treatment. Long term prognosis is dominated by the severity and number of comorbidities, age and the resulting frailty. Because in many patients all these informations are not available at the time of admission, in these cases a time-limited trial is often justified to gather all this information before a decision is made. These principles of decision making can also applied to situations in which ICU-capacities are limited (e. g. COVID-19 pandemic).
AD  - Internistische Intensivstation, Universitätsklinikum Tübingen, Tübingen, Deutschland.
Institut für Ethik, Geschichte und Theorie der Medizin, Ludwig-Maximilians-Universität München, München, Deutschland.
Sektion Nieren- und Hochdruckkrankheiten, Medizinische Klinik IV, Diabetologie, Endokrinologie und Nephrologie, Universitätsklinikum Tübingen, Tübingen, Deutschland.
AN  - 33022728
AU  - Riessen, R.
AU  - Haap, M.
AU  - Marckmann, G.
AU  - Mahling, M.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1055/a-1216-7614
DP  - NLM
ET  - 2020/10/07
IS  - 20
J2  - Deutsche medizinische Wochenschrift (1946)
LA  - ger
N1  - 1439-4413
Riessen, Reimer
Haap, Michael
Marckmann, Georg
Mahling, Moritz
English Abstract
Journal Article
Germany
Dtsch Med Wochenschr. 2020 Oct;145(20):1470-1475. doi: 10.1055/a-1216-7614. Epub 2020 Oct 6.
OP  - Rationale Therapieentscheidungen bei Intensivpatienten.
PY  - 2020
SN  - 0012-0472
SP  - 1470-1475
ST  - [Rational therapeutic decisions in intensive care patients]
T2  - Deutsche medizinische Wochenschrift (1946)
TI  - [Rational therapeutic decisions in intensive care patients]
VL  - 145
ID  - 7790950
ER  - 

TY  - JOUR
AB  - The challenge of learning a new concept, object, or a new medical disease recognition without receiving any examples beforehand is called Zero-Shot Learning (ZSL) One of the major issues in deep learning based methodologies such as in Medical Imaging and other real-world applications is the requirement of large annotated datasets prepared by clinicians or experts to train the model ZSL is known for having minimal human intervention by relying only on previously known or trained concepts plus currently existing auxiliary information This is ever-growing research for the cases where we have very limited or no annotated datasets available and the detection/recognition system has human-like characteristics in learning new concepts This makes the ZSL applicable in many real-world scenarios, from unknown object detection in autonomous vehicles to medical imaging and unforeseen diseases such as COVID-19 Chest X-Ray (CXR) based diagnosis In this review paper, we introduce a novel and broaden solution called Few/one-shot learning, and present the definition of the ZSL problem as an extreme case of the few-shot learning We review over fundamentals and the challenging steps of Zero-Shot Learning, including state-of-the-art categories of solutions, as well as our recommended solution, motivations behind each approach, their advantages over each category to guide both clinicians and AI researchers to proceed with the best techniques and practices based on their applications Inspired from different settings and extensions, we then review through different datasets inducing medical and non-medical images, the variety of splits, and the evaluation protocols proposed so far Finally, we discuss the recent applications and future directions of ZSL We aim to convey a useful intuition through this paper towards the goal of handling complex learning tasks more similar to the way humans learn We mainly focus on two applications in the current modern yet challenging era: coping with an early and fast diagnosis of COVID-19 cases, and also encouraging the readers to develop other similar AI-based automated detection/recognition systems using ZSL
AU  - Rezaei, Mahdi
AU  - Shahidi, Mahsa
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Zero-Shot Learning and its Applications from Autonomous Vehicles to COVID-19 Diagnosis: A Review
T2  - Intelligence-Based Medicine
TI  - Zero-Shot Learning and its Applications from Autonomous Vehicles to COVID-19 Diagnosis: A Review
UR  - https://doi.org/10.1016/j.ibmed.2020.100005
ID  - 7793166
ER  - 

TY  - JOUR
AB  - Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), presents with a broad range of symptoms. Existing COVID-19 case definitions were developed from early reports of severely ill, primarily hospitalized, patients. Symptom-based case definitions that guide public health surveillance and individual patient management in the community must be optimized for COVID-19 pandemic control. Methods: We collected daily symptom diaries and performed RT-PCR on respiratory specimens over a 14-day period in 185 community members exposed to a household contact with COVID-19 in the Milwaukee, Wisconsin and Salt Lake City, Utah metropolitan areas. We interpreted the discriminatory performance (sensitivity, specificity, predictive values, F-1 score, Youden&#039;s index, and prevalence estimation) of individual symptoms and common case definitions according to two principal surveillance applications (i.e., individual screening and case counting). We also constructed novel case definitions using an exhaustive search with over 73 million symptom combinations and calculated bias-corrected and accelerated bootstrap confidence intervals stratified by children versus adults. Findings: Common COVID-19 case definitions generally showed high sensitivity (86-96%) but low positive predictive value (PPV) (36-49%; F-1 score 52-63) in this community cohort. The top performing novel symptom combinations included taste or smell dysfunction. They also improved the balance of sensitivity and PPV (F-1 score 78-80) and reduced the number of false positive symptom screens. Performance indicators were generally lower for children (&amp;lt;18 years of age). Interpretation: Existing COVID-19 case definitions appropriately screened in community members with COVID-19. However, they led to many false positive symptom screens and poorly estimated community prevalence. Absent unlimited, timely testing capacity, more accurate case definitions may help focus public health resources. Novel symptom combinations incorporating taste or smell dysfunction as a primary component better balanced sensitivity and specificity. Case definitions tailored specifically for children versus adults should be further explored.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis research was wholly supported by the U.S. Centers for Disease Control and Prevention. The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the U.S. Centers for Disease Control and Prevention/the Agency for Toxic Substances and Disease Registry.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This protocol was reviewed by the Associate Director for Science of the 2019 Novel Coronavirus Response and the activity was deemed nonresearch as part of the COVID-19 public health response. This is the CDC process for ethics review; the authors had no role in this decision. The activity was conducted consistent with applicable federal law and CDC policy. See e.g., 45 C.F.R. part 46, 21 C.F.R. part 56; 42 U.S.C. 241(d);5 U.S.C. 552a; 44 U.S.C. 3501 et seq.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the elevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesDe-identified data and analytic scripts in R and Python are publicly available through a GitHub repository: https://github.com/scotthlee/covid-casedefs.https://github.com/scotthlee/covid-casedefs
AU  - Reses, Hannah E.
AU  - Fajans, Mark
AU  - Lee, Scott H.
AU  - Heilig, Charles M.
AU  - Chu, Victoria T.
AU  - Thornburg, Natalie J.
AU  - Christensen, Kim
AU  - Bhattacharyya, Sanjib
AU  - Fry, Alicia
AU  - Hall, Aron J.
AU  - Tate, Jacqueline E.
AU  - Kirking, Hannah L.
AU  - Nabity, Scott A.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20195479
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20195479
ST  - Performance of Existing and Novel Surveillance Case Definitions for COVID-19 in the Community (preprint)
T2  - medRxiv
TI  - Performance of Existing and Novel Surveillance Case Definitions for COVID-19 in the Community (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.02.20195479.abstract
ID  - 7794744
ER  - 

TY  - JOUR
AB  - BACKGROUND: Since the beginning of the outbreak, the COVID-19 pandemic has caused an increased demand for psychosocial support for patients, their family members, and healthcare workers. Concurrently, possibilities to provide this support have been hindered. Quarantine, social isolation, and SARS-CoV�? infections represent new and severe stressors that have to be addressed with innovative psychosocial care. OBJECTIVE AND METHOD: This article describes the COVID-19 psychosocial first aid concept at the University Hospital Munich (LMU Klinikum) developed by an interdisciplinary team of psychiatric, psychological, spiritual care, psycho-oncological, and palliative care specialists. RESULTS: A new psychosocial first aid model has been implemented for COVID-19 inpatients, family members, and hospital staff consisting of five elements. CONCLUSION: The concept integrates innovative and sustainable ideas, e.g. telemedicine-based approaches and highlights the importance of multidisciplinary collaboration to cope with challenges in the healthcare system.
AD  - Klinik für Psychiatrie und Psychotherapie, LMU Klinikum, Nußbaumstraße 7, 80336, München, Deutschland. Matthias.reinhard@med.uni-muenchen.de.
Klinik für Psychiatrie und Psychotherapie, LMU Klinikum, Nußbaumstraße 7, 80336, München, Deutschland.
Medizinische Klinik und Poliklinik III, LMU Klinikum, München, Deutschland.
Seelsorge, LMU Klinikum, München, Deutschland.
Klinik und Poliklinik für Palliativmedizin, LMU Klinikum, München, Deutschland.
Zentrale Notaufnahme, LMU Klinikum, München, Deutschland.
Neurologische Klinik und Poliklinik, LMU Klinikum, München, Deutschland.
Klinik für Allgemeine, Viszeral, Transplantations- Gefäß- und Thoraxchirurgie, LMU Klinikum, München, Deutschland.
AN  - 33025071
AU  - Reinhard, M. A.
AU  - Burkhardt, G.
AU  - Grosse-Wentrup, F.
AU  - Eser-Valerie, D.
AU  - Mumm, F. H. A.
AU  - Barnikol-Oettler, B.
AU  - Bausewein, C.
AU  - von Bergwelt-Baildon, M.
AU  - Klein, M.
AU  - Falkai, P.
AU  - Jauch, K. W.
AU  - Adorjan, K.
AU  - Padberg, F.
AU  - Hoch, E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00115-020-01014-8
DP  - NLM
ET  - 2020/10/08
J2  - Der Nervenarzt
KW  - COVID-19 pandemic
Interdisciplinarity
Psychological first aid
Psychosocial care
Video-based psychotherapy
LA  - ger
N1  - 1433-0407
Reinhard, Matthias A
Burkhardt, Gerrit
Grosse-Wentrup, Fabienne
Eser-Valerie, Daniela
Mumm, Friederike H A
Barnikol-Oettler, Bernhard
Bausewein, Claudia
von Bergwelt-Baildon, Michael
Klein, Matthias
Falkai, Peter
Jauch, Karl-Walter
Adorjan, Kristina
Padberg, Frank
Hoch, Eva
English Abstract
Journal Article
Review
Germany
Nervenarzt. 2020 Oct 6. doi: 10.1007/s00115-020-01014-8.
OP  - Psychosoziale Unterstützung während der COVID-19-Pandemie: interdisziplinäres Versorgungskonzept an einem Universitätsklinikum.
PY  - 2020
SN  - 0028-2804
ST  - [Psychosocial support during the COVID-19 pandemic: interdisciplinary concept of care at a university hospital]
T2  - Der Nervenarzt
TI  - [Psychosocial support during the COVID-19 pandemic: interdisciplinary concept of care at a university hospital]
ID  - 7790724
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis revealed multiple independent sources of introductions of SARS-CoV-2 into Turkey and a close relationship to the isolates from Saudi Arabia.
AD  - Department of Botany, Rawalpindi Women University, Rawalpindi, Pakistan. shaziarehman7@gmail.com.
Department of Botany, Govt. Gordon College Rawalpindi, Rawalpindi, Pakistan. shaziarehman7@gmail.com.
Department of Plant Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.
Department of Botany, GDC Khanpur, Haripur, Pakistan.
University Institute of Biochemistry and Biotechnology, PMAS-UAAR, Rawalpindi, Pakistan.
AN  - 33025199
AU  - Rehman, S.
AU  - Mahmood, T.
AU  - Aziz, E.
AU  - Batool, R.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00705-020-04830-0
DP  - NLM
ET  - 2020/10/08
J2  - Archives of virology
LA  - eng
N1  - 1432-8798
Rehman, Shazia
Orcid: 0000-0003-1435-6166
Mahmood, Tariq
Aziz, Ejaz
Batool, Riffat
Journal Article
Austria
Arch Virol. 2020 Oct 6. doi: 10.1007/s00705-020-04830-0.
PY  - 2020
SN  - 0304-8608
ST  - Identification of novel mutations in SARS-COV-2 isolates from Turkey
T2  - Archives of virology
TI  - Identification of novel mutations in SARS-COV-2 isolates from Turkey
ID  - 7790722
ER  - 

TY  - JOUR
AB  - ABSTRACT Aedes aegypti (Linn ) and Aedes albopictus (Skuse) are widespread vector mosquitoes responsible for the transmission of various disease-causing viruses to human including dengue virus (DENV) India is endemic for dengue disease and both of these vector mosquitoes are well established throughout India Since, Aedes mosquitoes breeds in containers, WHO recommends to do a regular immature surveillance and implement appropriate control measures Owing to the current COVID-19 pandemic, most of the countries have implemented continuous shutdown/lockdown, which affected the routine Aedes surveillance and vector control measures In India, the first nation-wide lockdown was implemented on 24th, March 2020 As of now, Government of India has extended the lockdown till 30th, June 2020 In the present study, two rounds of Aedes surveillance was carried out in two localities of Bangalore City (urban) of Karnataka State, India during the COVID-19 lockdown days and results were compared with pre- lockdown surveillance data to assess the impact of lockdown on Aedes larval indices, breeding habitats and dengue vector control programme The recorded house index (HI) and Breteau index (BI) were 6 6 and 9 3 in K P Agrahara and 4 0 and 5 3 in Palace Guttahalli during pre-lockdown survey The house index (HI) and Breteau index (BI) were found to be increased to 26 6 and 34 6 in K P Agrahara and 21 3 and 28 0 in Palace Guttahalli during the COVID-19 lockdown second survey Aedes immature density has drastically increased in both the localities due to temporarily discontinued Aedes surveillance, larval control activities like source reduction and anti-larval measures during COVID-19 lockdown The high indices show that the dengue virus transmission will be increasing in the coming days The results highly recommend to implement the Aedes vector control programme with limited health staffs following the physical distance and other protectives measures to prevent dengue outbreaks
AU  - Reegan, Appadurai Daniel
AU  - Gandhi, Munusamy Rajiv
AU  - Asharaja, Antony Cruz
AU  - Devi, Chitra
AU  - Shanthakumar, Shanmugam Perumal
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 lockdown: Impact assessment on Aedes larval indices, breeding habitats, effects on vector control programme and prevention of dengue outbreaks
T2  - Heliyon
TI  - COVID-19 lockdown: Impact assessment on Aedes larval indices, breeding habitats, effects on vector control programme and prevention of dengue outbreaks
UR  - https://doi.org/10.1016/j.heliyon.2020.e05181
ID  - 7793170
ER  - 

TY  - JOUR
AU  - Reade, J. James
AU  - Schreyer, Dominik
AU  - Singleton, Carl
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Stadium attendance demand during the COVID-19 crisis: early empirical evidence from Belarus
T2  - Applied Economics Letters
TI  - Stadium attendance demand during the COVID-19 crisis: early empirical evidence from Belarus
UR  - https://doi.org/10.1080/13504851.2020.1830933
ID  - 7792962
ER  - 

TY  - JOUR
AB  - Objective: Worldwide countries are experiencing viral load in their population, leading to potential infectivity of asymptomatic COVID-19. Current systematic review and meta-analysis aimed to investigate the role of asymptomatic infection worldwide reported in family-cluster, adults, children, health care workers, and travelers. Design: Online literature search (PubMed, Google Scholar, medRixv, and BioRixv) was accomplished using standard Boolean operators, studies published till 07th June 2020. Setting: Studies were included from case reports, short communication, and retrospective to cover sufficient asymptomatic COVID-19 transmission reported. Participants: Familial-clusters, adults, children, health care workers, and travelers. Results: We observed asymptomatic transmission among familial-cluster, adults, children, health care workers, and travelers with a proportion of 32% 37%, 26%, 6%, and 32%, respectively. This study observed an overall proportion of 31% (95%CI: 0.19-0.44) with heterogeneity of I2 (97.28%, p=&amp;lt;0.001) among all asymptomatic populations mentioned in this study. Among children and healthcare workers, this study showed no heterogeneity; to overcome the interpretation from a fixed model, the random effect model was also applied to estimate the average distribution across studies included in the meta-analysis. Conclusion: We found and suggest the rigorous epidemiological history, early isolation, social distancing, and increased quarantine period (at least 28 days) after screening asymptomatic cases as well as their close contacts for chest CT scan even after their negative nucleic acid testing to minimize the spread among the community. This systematic review and meta-analysis support asymptomatic COVID-19 transmission between person to person depending on the variation of virus incubation period among individuals. Children especially, school-going aged &amp;lt;18 years, need to be monitored and prevention strategy, e.g., chest CT and social distancing required to prevent the community transmission of COVID-19 in asymptomatic mode.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNAAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Not requiredAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesNo additional data available.
AU  - Ravindra, Khaiwal
AU  - Malik, Vivek Singh
AU  - Padhi, Bijaya K.
AU  - Goel, Sonu
AU  - Gupta, Madhu
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.06.20207597
DP  - medRxiv
PY  - 2020
SP  - 2020.10.06.20207597
ST  - Consideration for the asymptomatic transmission of COVID-19: Systematic Review and Meta-Analysis (preprint)
T2  - medRxiv
TI  - Consideration for the asymptomatic transmission of COVID-19: Systematic Review and Meta-Analysis (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.06.20207597.abstract
ID  - 7794727
ER  - 

TY  - JOUR
AB  - Importance: Particulate respirators such as N95 masks are an essential component of personal protective equipment (PPE) for front-line workers. This study describes a rapid and effective UVC irradiation system that would facilitate the safe re-use of N95 respirators and provides supporting information for deploying UVC for decontamination of SARS-CoV-2 during the COVID19 pandemic. Objective: To assess the inactivation potential of the proposed UVC germicidal device as a function of time by using 3M 8211 - N95 particulate respirators inoculated with SARS-CoV-2. Design: A germicidal UVC device to deliver tailored UVC dose was developed and snippets (2.5cm2) of the 3M-N95 respirator were inoculated with 106 plaque-forming units (PFU) of SARS-CoV-2 and were UV irradiated. Different exposure times were tested (0-164 seconds) by fixing the distance between the lamp (10 cm) and the mask while providing an exposure of at least 5.43 mWcm-2. Setting: The current work is broadly applicable for healthcare-settings, particularly during a pandemic such as COVID-19. Participants: Not applicable. Main Outcome(s) and Measure(s): Primary measure of outcome was titration of infectious virus recovered from virus-inoculated respirator pieces after UVC exposure. Other measures included the method validation of the irradiation protocol, using lentiviruses (biosafety level-2 agent) and establishment of the germicidal UVC exposure protocol. Results: An average of 4.38x103 PFUml-1(SD 772.68) was recovered from untreated masks while 4.44x102 PFUml-1(SD 203.67), 4.00x102 PFUml-1(SD 115.47), 1.56x102 PFUml-1(SD 76.98) and 4.44x101 PFUml-1(SD 76.98) was recovered in exposures 2s,6s,18s and 54 seconds per side respectively. The germicidal device output and positioning was monitored and a minimum output of 5.43 mWcm-2 was maintained. Infectious SARS-CoV-2 was not detected by plaque assays (minimal level of detection is 67 PFUml-1) on N95 respirator snippets when irradiated for 120s per side or longer suggesting 3.5 log reduction in 240 seconds of irradiation. Conclusions and Relevance: A scalable germicidal UVC device to deliver tailored UVC dose for rapid decontamination of SARS-CoV-2 was developed. UVC germicidal irradiation of N95 snippets inoculated with SARS-CoV-2 for 120s per side resulted in 100% (3.5 log in total) reduction of virus. These data support the reuse of N95 particle-filtrate apparatus upon irradiation with UVC and supports use of UVC-based decontamination of SARS-CoV-2 virus during the COVID19 pandemic.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis research was partly funded by CRIP (Center for Research for Influenza Pathogenesis), a NIAID supported Center of Excellence for Influenza Research and Surveillance (CEIRS, contract # HHSN272201400008C); by the generous support of the JPB Foundation, the Open Philanthropy Project (research grant 2020-215611 (5384)), anonymous donors to AG-S, funds from Rensselaer Polytechnic Institute and NIH (5UL1TR001433).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The reported finding did not involve research on human subjects.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting hecklist(s) and other pertinent material as supplementary files, if applicable.YesData can be made available through email request to the corresponding author, Dr. Priti Balchandani.
AU  - Rathnasinghe, Raveen
AU  - Karlicek, Robert F.
AU  - Schotsaert, Michael
AU  - Koffas, Mattheos A.
AU  - Arduini, Brigitte
AU  - Jangra, Sonia
AU  - Wang, Bowen
AU  - Davis, Jason L.
AU  - Alnaggar, Mohammed
AU  - Costa, Anthony
AU  - Vincent, Richard
AU  - Garcia-Sastre, Adolfo
AU  - Vashishth, Deepak
AU  - Balchandani, Priti
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206953
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206953
ST  - Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultra-violet C (UVC) irradiation device (preprint)
T2  - medRxiv
TI  - Scalable, effective, and rapid decontamination of SARS-CoV-2 contaminated N95 respirators using germicidal ultra-violet C (UVC) irradiation device (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206953.abstract
ID  - 7794734
ER  - 

TY  - JOUR
AB  - INTRODUCTION: A novel coronavirus named severe acute respiratory syndrome coronavirus 2, was first reported in Wuhan, China, in December 2019. The virus, known as COVID-19, is recognized as a potentially life-threatening disease by causing severe respiratory disease. Since this virus has not previously been detected in humans, there is a paucity of information regarding its effects on humans. In addition, only limited or no information exists about its impact during pregnancy. CASE PRESENTATION: In the present case study, we report the death of a neonate born to a 32-year-old mother with coronavirus disease 2019 in Ilam, Iran, with Kurdish ethnicity. We report the infection and death of a neonate in Iran with a chest X-ray (CXR) marked abnormality 2 hours after birth demonstrating coronavirus disease 2019 disease. The neonate was born by elective cesarean section, the fetal health was assessed using fetal heart rate and a non-stress test before the birth, and there was no evidence of fetal distress. All the above-mentioned facts and radiographic abnormalities suggested that coronavirus disease 2019 is involved. CONCLUSIONS: In this case study, we report the death of a neonate born to a mother with coronavirus disease 2019, 11 hours after birth. There is a paucity of data on the vertical transmission and the adverse maternal-fetal consequences of this disease, so vertical transmission from mother to child remains to be confirmed.
AD  - Department of Obstetrics and Gynecology, Medical School, Ilam University of Medical Sciences, Ilam, Iran.
Department of Midwifery, School of Nursing & Midwifery, Ilam University of Medical Sciences, Ilam, Iran. nasibe.sharifi@yahoo.com.
Department of Midwifery, Faculty of Nursing and Midwifery Islamic Azad University, Tabriz Branch, Tabriz, Iran.
Department of Pediatrics, Medical School, Ilam University of Medical Sciences, Ilam, Iran.
Department of Internal Medicine, Medical School, Ilam University of Medical Sciences, Ilam, Iran.
AN  - 33023635
AU  - Rashidian, T.
AU  - Sharifi, N.
AU  - Fathnezhad-Kazemi, A.
AU  - Mirzamrajani, F.
AU  - Nourollahi, S.
AU  - Ghaysouri, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13256-020-02519-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Journal of medical case reports
KW  - Coronavirus 19
Infant death
Mother-to-child transmissions
Novel coronavirus
LA  - eng
N1  - 1752-1947
Rashidian, Tayebeh
Sharifi, Nasibeh
Fathnezhad-Kazemi, Azita
Mirzamrajani, Fatemeh
Nourollahi, Sajad
Ghaysouri, Abas
Journal Article
England
J Med Case Rep. 2020 Oct 6;14(1):186. doi: 10.1186/s13256-020-02519-1.
PY  - 2020
SN  - 1752-1947
SP  - 186
ST  - Death of a neonate with suspected coronavirus disease 2019 born to a mother with coronavirus disease 2019 in Iran: a case report
T2  - Journal of medical case reports
TI  - Death of a neonate with suspected coronavirus disease 2019 born to a mother with coronavirus disease 2019 in Iran: a case report
VL  - 14
ID  - 7790897
ER  - 

TY  - JOUR
AB  - Background Studies have reported significant reduction in acute myocardial infarction (AMI) related hospitalizations during the COVID19 pandemic. However, whether these trends are associated with increased incidence of Out of Hospital Cardiac Arrest (OHCA) in this population is unknown. Methods and Results AMI hospitalizations with OHCA during the COVID19 period (1(st) February-14(th) May 2020) from the Myocardial Ischaemia National Audit Project and British Cardiovascular Intervention Society datasets were analysed. Temporal trends were assessed using Poisson models with equivalent pre-COVID19 period (1(st) February-14(th) May 2019) as reference. AMI hospitalizations during COVID19 period were reduced by more than 50% (n=20,310 vs n=9,325). OHCA was more prevalent during the COVID-19 period compared with the pre-COVID period (5.6% vs. 3.6%), with a 56% increase in the incidence of OHCA (incidence rate ratio: 1.56, 95%CI 1.39-1.74). OHCA patients during COVID19 period were likely to be older, female, of Asian ethnicity and more likely to present with STEMI. The overall rates of invasive coronary angiography (58.4% vs. 71.6%, p0.001) were significantly lower amongst the OHCA during COVID19 period with increased time to reperfusion (mean 2.1 hours vs. 1.1 hours, p=0.05) in STEMI. The adjusted in-hospital mortality probability increased from 27.7% in February 2020 to 35.8% in May 2020 in the COVID19 group (p 0.001). Conclusions In this national cohort of hospitalized AMI patients, we observed a significant rise in incidence of OHCA during COVID period paralleled with reduced access to guidelines recommended care and increased in-hospital mortality.
AD  - Keele Cardiovascular Research Group Institute for Prognosis Research School of Primary Care Keele University.
Department of Cardiology Royal Stoke Hospital Stoke-on-Trent UK.
Leeds Institute for Data Analytics University of Leeds Leeds UK.
Leeds Institute for Cardiovascular and Metabolic Medicine University of Leeds Leeds UK.
Leeds Teaching Hospitals NHS Trust Leeds UK.
Coronary Research Group University Hospital Southampton & Faculty of Medicine, University of Southampton UK.
Department of Cardiology Queen Elizabeth Hospital Birmingham Birmingham UK.
National Institute for Cardiovascular Outcomes Research Barts Health NHS Trust London UK.
Barts Heart Centre Queen Mary University London UK.
Royal Brompton & Harefield Hospitals and Imperial College London UK.
Center for Molecular Cardiology University of Zurich Switzerland.
University of Manchester, Division of Population Health, Health Services Research and Primary Care Manchester UK.
NHS Digital Leeds UK.
Institute of Cardiovascular Sciences University College London London UK.
Department of Medicine Thomas Jefferson University Philadelphia PA USA.
AN  - 33023348
AU  - Rashid, M.
AU  - Gale, C. P.
AU  - Curzen, N.
AU  - Ludman, P.
AU  - De Belder, M.
AU  - Timmis, A.
AU  - Mohamed, M. O.
AU  - Lüscher, T. F.
AU  - Hains, J.
AU  - Wu, J.
AU  - Shoaib, A.
AU  - Kontopantelis, E.
AU  - Roebuck, C.
AU  - Denwood, T.
AU  - Deanfield, J.
AU  - Mamas, M. A.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1161/jaha.120.018379
DP  - NLM
ET  - 2020/10/08
J2  - Journal of the American Heart Association
KW  - Covid19
Incidence
Out of hospital cardiac arrest
acute myocardial infarction
mortality
LA  - eng
N1  - 2047-9980
Rashid, Muhammad
Gale, Chris P
Curzen, Nick
Ludman, Peter
De Belder, Mark
Timmis, Adam
Mohamed, Mohamed O
Lüscher, Thomas F
Hains, Julian
Wu, Jianhua
Shoaib, Ahmad
Kontopantelis, Evangelos
Roebuck, Chris
Denwood, Tom
Deanfield, John
Mamas, Mamas A
Journal Article
England
J Am Heart Assoc. 2020 Oct 7:e018379. doi: 10.1161/JAHA.120.018379.
PY  - 2020
SN  - 2047-9980
SP  - e018379
ST  - Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England
T2  - Journal of American Heart Association
TI  - Impact of COVID19 Pandemic on the Incidence and Management of Out of Hospital Cardiac Arrest in Patients Presenting with Acute Myocardial Infarction in England
ID  - 7790917
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the urgent need to rapidly develop therapeutic strategies for such emerging viruses without effective vaccines or drugs. Here, we report a decoy nanoparticle against COVID-19 through a powerful two-step neutralization approach: virus neutralization in the first step followed by cytokine neutralization in the second step. The nanodecoy, made by fusing cellular membrane nanovesicles derived from human monocytes and genetically engineered cells stably expressing angiotensin converting enzyme II (ACE2) receptors, possesses an antigenic exterior the same as source cells. By competing with host cells for virus binding, these nanodecoys effectively protect host cells from the infection of pseudoviruses and authentic SARS-CoV-2. Moreover, relying on abundant cytokine receptors on the surface, the nanodecoys efficiently bind and neutralize inflammatory cytokines including interleukin 6 (IL-6) and granulocyte-macrophage colony-stimulating factor (GM-CSF), and significantly suppress immune disorder and lung injury in an acute pneumonia mouse model. Our work presents a simple, safe, and robust antiviral nanotechnology for ongoing COVID-19 and future potential epidemics.
AD  - Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892.
Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Institute of Medical Microbiology, Jinan University, 510632 Guangzhou, China.
State Key Laboratory of Virology, College of Life Sciences, Wuhan University, 430072 Wuhan, China.
School of Physics and Technology, Wuhan University, 430072 Wuhan, China.
Biosafety Level 3 Laboratory, Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China; lul@fudan.edu.cn yhxie@fudan.edu.cn shibojiang@fudan.edu.cn chen9647@gmail.com.
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, MD 20892; lul@fudan.edu.cn yhxie@fudan.edu.cn shibojiang@fudan.edu.cn chen9647@gmail.com.
AN  - 33024017
AU  - Rao, L.
AU  - Xia, S.
AU  - Xu, W.
AU  - Tian, R.
AU  - Yu, G.
AU  - Gu, C.
AU  - Pan, P.
AU  - Meng, Q. F.
AU  - Cai, X.
AU  - Qu, D.
AU  - Lu, L.
AU  - Xie, Y.
AU  - Jiang, S.
AU  - Chen, X.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1073/pnas.2014352117
DP  - NLM
ET  - 2020/10/08
J2  - Proceedings of the National Academy of Sciences of the United States of America
KW  - Covid-19
SARS-CoV-2
cell membrane vesicle
cytokine storm
nanodecoy
this study.
LA  - eng
N1  - 1091-6490
Rao, Lang
Orcid: 0000-0001-5010-0729
Xia, Shuai
Xu, Wei
Tian, Rui
Yu, Guocan
Gu, Chenjian
Pan, Pan
Meng, Qian-Fang
Cai, Xia
Qu, Di
Lu, Lu
Orcid: 0000-0002-2255-0391
Xie, Youhua
Jiang, Shibo
Chen, Xiaoyuan
Orcid: 0000-0002-9622-0870
Journal Article
United States
Proc Natl Acad Sci U S A. 2020 Oct 6:202014352. doi: 10.1073/pnas.2014352117.
PY  - 2020
SN  - 0027-8424
ST  - Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines
T2  - Proceedings of National Academy of Sciences of United States of America
TI  - Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines
ID  - 7790852
ER  - 

TY  - JOUR
AD  - Department of Internal Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY.
Department of Emergency Medicine, Metropolitan Hospital Center, Valhalla, NY.
Department of Cardiology, New York Medical College and Westchester Medical Center, Valhalla, NY.
AN  - 33021529
AU  - Ranchal, P.
AU  - Yates, E.
AU  - Gupta, R.
AU  - Aronow, W. S.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1097/mjt.0000000000001273
DP  - NLM
ET  - 2020/10/07
J2  - American journal of therapeutics
LA  - eng
N1  - 1536-3686
Ranchal, Purva
Yates, Evan
Gupta, Rahul
Aronow, Wilbert S
Journal Article
United States
Am J Ther. 2020 Oct 1. doi: 10.1097/MJT.0000000000001273.
PY  - 2020
SN  - 1075-2765
ST  - Tocilizumab-Associated Bowel Perforation in SARS-CoV-2 Infection
T2  - American journal of therapeutics
TI  - Tocilizumab-Associated Bowel Perforation in SARS-CoV-2 Infection
ID  - 7791023
ER  - 

TY  - JOUR
AB  - The present work proposes a surrogate method for understanding and analyzing the replication of SARS CoV-2 through fractal and inertia moment (IM) analysis of cell culture images at different stages. The fractal analysis of images of cell culture, calculated by the box-counting and power spectral density methods, reflect the stages of virus infection, leading to the replication of the virus RNA and damaging the host cell. The linear increase of IM value reveals not only the proliferation of SARS CoV-2 by replication but also damage to the host cell with time. Thus, the work shows the possibility of fractal analysis and IM measurement for understanding the dynamics of the virus infection.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNO FUNDINGAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NOT APPLICABLEAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data that support the findings of this study are available from the corresponding author upon reasonable request.
AU  - Raj, Vimal
AU  - Sreejyothi, S.
AU  - Swapna, M. S.
AU  - Sankararaman, S.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206185
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206185
ST  - Fractal and inertia moment analysis of SARS CoV-2 proliferation through replication (preprint)
T2  - medRxiv
TI  - Fractal and inertia moment analysis of SARS CoV-2 proliferation through replication (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206185.abstract
ID  - 7794768
ER  - 

TY  - JOUR
AB  - The emergency department (ED) is one of the busiest facilities in a hospital, and it is frequently described as a bottleneck that limits space and structures, jeopardising surge capacity during Major Incidents and Disasters (MIDs) and pandemics such as the COVID 19 outbreak One remedy to facilitate surge capacity is to establish an Urgent Care Centre (UCC), i e , a secondary ED, co-located and in close collaboration with an ED This study investigates the outcome of treatment in an ED versus a UCC in terms of length of stay (LOS), time to physician (TTP) and use of medical services If it was possible to make these parameters equal to or even less than the ED, UCCs could be used as supplementary units to the ED, improving sustainability The results show reduced waiting times at the UCC, both in terms of TTP and LOS In conclusion, creating a primary care-like facility in close proximity to the hospitals may not only relieve overcrowding of the hospital&amp;rsquo;s ED in peacetime, but it may also provide an opportunity for use during MIDs and pandemics to facilitate the victims of the incident and society as a whole
AU  - Raidla, Annelie
AU  - Darro, Katrin
AU  - Carlson, Tobias
AU  - Khorram-Manesh, Amir
AU  - Berlin, Johan
AU  - Carlström, Eric
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Outcomes of Establishing an Urgent Care Centre in the Same Location as an Emergency Department
T2  - Sustainability
TI  - Outcomes of Establishing an Urgent Care Centre in the Same Location as an Emergency Department
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813254
ID  - 7793338
ER  - 

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVE: The incubation period of COVID-19 helps to determine the optimal duration of the quarantine and inform predictive models of incidence curves. Several emerging studies have produced varying results; this systematic review aims to provide a more accurate estimate of the incubation period of COVID-19. METHODS: For this systematic review, a literature search was conducted using Pubmed, Scopus/EMBASE, and the Cochrane Library databases, covering all observational and experimental studies reporting the incubation period and published from 1 January 2020 to 21 March 2020.We estimated the mean and 95th percentile of the incubation period using meta-analysis, taking into account between-study heterogeneity, and the analysis with moderator variables. RESULTS: We included seven studies (N= 792) in the meta-analysis. The heterogeneity (I(2) 83.0%, p 0.001)was significantly decreased when we included the study quality and the statistical model used as moderator variables (I(2) 15%). The mean incubation period ranged from 5.6 (95%CI: 5.2 to 6.0) to 6.7 days (95% CI: 6.0 to 7.4) according to the statistical model. The 95(th) percentile was 12.5 days when the mean age of patients was 60 years, increasing 1 day for every 10 years. CONCLUSION: Based on the published data reporting the incubation period of COVID-19, the mean time between exposure and onset of clinical symptoms depended on the statistical model used, and the 95th percentile depended on the mean age of the patients. It is advisable to record sex and age when collecting data in order to analyze possible differential patterns.
AD  - Departamento de Medicina Cl�Tnica, Universidad Miguel Hern֙ndez de Elche, San Juan de Alicante, España.
Departamento de Neumolog�Ta, Universidad Hospital de San Juan de Alicante, San Juan de Alicante, España.
Departamento de Enfermedades Infecciosas, Universidad Hospital de Elche, Elche, España.
AN  - 33024342
AU  - Quesada, J. A.
AU  - L�Qpez-Pineda, A.
AU  - Gil-Guillén, V. F.
AU  - Arriero-Mar�Tn, J. M.
AU  - Gutiérrez, F.
AU  - Carratala-Munuera, C.
C1  - 10/7/2020
C2  - PMC7528969
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.rce.2020.08.005
DP  - NLM
ET  - 2020/10/08
J2  - Revista clinica espanola
KW  - Coronavirus
Infectious Disease Incubation Period
Public Health
LA  - spa
N1  - 1578-1860
Quesada, J A
L�Qpez-Pineda, A
Gil-Guillén, V F
Arriero-Mar�Tn, J M
Gutiérrez, F
Carratala-Munuera, C
English Abstract
Journal Article
Review
Spain
Rev Clin Esp. 2020 Oct 1. doi: 10.1016/j.rce.2020.08.005.
OP  - Per�Todo de incubaci�Qn de la COVID-19: revisi�Qn sistem֙tica y metaan֙lisis.
PY  - 2020
SN  - 0014-2565
ST  - [Incubation period of COVID-19: A systematic review and meta-analysis]
T2  - Revista clinica espanola
TI  - [Incubation period of COVID-19: A systematic review and meta-analysis]
ID  - 7790819
ER  - 

TY  - JOUR
AB  - Suicide is one of the top 20 leading causes of death worldwide. With the rapid spreading of coronavirus disease 2019 (COVID-19) crisis around the world, suicide cases induced by the COVID-19 pandemic have been reported in many countries. Individuals with suspected and confirmed COVID-19 infection, frontline healthcare workers, bereaved families, elders, children, and adolescents are vulnerable populations who might be at elevated suicide risk. In this micro-review, a systematic search through PubMed was performed for a comprehensive investigation of suicide risk factors during the pandemic. On this basis, we put forward considerations and advice for preventing pandemic related suicide, including staying socially connected through online platform or apps during period of quarantine, reducing unemployment, dispelling rumors and misinformation in time, and maintaining evidenced-based management of psychiatric symptoms. More importantly, early detection and timely intervention of individuals with psychiatric disorders and suicide behaviors will be effective to reduce the number of suicides, with specific measurements of using validated scales to perform regular suicide risk screening, improving the availability of mental health services, and providing appropriate and evidence-based interventions for individuals in demand. Policy makers, psychiatrists, psychologists, and other healthcare professionals need to collaborate to control the possible suicide events during the COVID-19 pandemic and future possible crisis.
AD  - Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China.
National Institute on Drug Dependence, Peking University, Beijing, China.
AN  - 33022901
AU  - Que, J.
AU  - Yuan, K.
AU  - Gong, Y.
AU  - Meng, S.
AU  - Bao, Y.
AU  - Lu, L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/npr2.12141
DP  - NLM
ET  - 2020/10/07
J2  - Neuropsychopharmacology reports
KW  - Covid-19
infectious disease
suicide prevention
LA  - eng
N1  - 2574-173x
Que, Jianyu
Orcid: 0000-0003-0660-5134
Yuan, Kai
Gong, Yimiao
Meng, Shiqiu
Bao, Yanping
Lu, Lin
81761128036/National Natural Science Foundation of China/
BMU2020HKYZX008/Special Research Fund of PKUHSC for Prevention and Control of COVID-19/
Journal Article
Review
United States
Neuropsychopharmacol Rep. 2020 Oct 6. doi: 10.1002/npr2.12141.
PY  - 2020
SN  - 2574-173x
ST  - Raising awareness of suicide prevention during the COVID-19 pandemic
T2  - Neuropsychopharmacology reports
TI  - Raising awareness of suicide prevention during the COVID-19 pandemic
ID  - 7790935
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic and the move to telemedicine for office-based opioid treatment have made the practice of routine urine drug tests (UDT) obsolete In this commentary we discuss how COVID-19 has demonstrated the limited usefulness and possible harms of routine UDT We propose that practitioners should stop using routine UDT and instead use targeted UDT, paired with clinical reasoning, as part of a patient-centered approach to care
AU  - Pytell, Jarratt D.
AU  - Rastegar, Darius A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Down the drain: Reconsidering routine urine drug testing during the COVID-19 pandemic
T2  - Journal of Substance Abuse Treatment
TI  - Down the drain: Reconsidering routine urine drug testing during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.jsat.2020.108155
ID  - 7793113
ER  - 

TY  - JOUR
AB  - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human respiratory viral infection that has rapidly progressed into a pandemic, causing significant morbidity and mortality. Blood clotting disorders and acute respiratory failure have surfaced as the major complications among the severe cases of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection. Remarkably, more than 70% of deaths related to COVID-19 are attributed to clotting-associated complications such as pulmonary embolism, strokes and multi-organ failure. These vascular complications have been confirmed by autopsy. This study summarizes the current understanding and explains the possible mechanisms of the blood clotting disorder, emphasizing the role of (1) hypoxia-related activation of coagulation factors like tissue factor, a significant player in triggering coagulation cascade, (2) cytokine storm and activation of neutrophils and the release of neutrophil extracellular traps and (3) immobility and ICU related risk factors.
AD  - Department of Pharmacology Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
Departments of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
AN  - 33022790
AU  - Pujhari, S.
AU  - Paul, S.
AU  - Ahluwalia, J.
AU  - Rasgon, J. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/rmv.2177
DP  - NLM
ET  - 2020/10/07
J2  - Reviews in medical virology
KW  - Covid-19
Il-6
SARS-CoV-2
cytokine storm
pulmonary embolism
thrombosis
LA  - eng
N1  - 1099-1654
Pujhari, Sujit
Orcid: 0000-0001-5856-5328
Paul, Sanjeeta
Ahluwalia, Jasmina
Rasgon, Jason L
Orcid: 0000-0002-4050-8429
Journal Article
England
Rev Med Virol. 2020 Oct 6:e2177. doi: 10.1002/rmv.2177.
PY  - 2020
SN  - 1052-9276
SP  - e2177
ST  - Clotting disorder in severe acute respiratory syndrome coronavirus 2
T2  - Reviews in medical virology
TI  - Clotting disorder in severe acute respiratory syndrome coronavirus 2
ID  - 7790943
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major global concern. Several SARS-CoV-2 gene mutations have been reported. In the current study associations between SARS-CoV-2 gene variation and exposure history during the first wave of the outbreak in Thailand between January and May 2020 were investigated. Forty samples were collected at different time points during the outbreak, and parts of the SARS-CoV-2 genome sequence were used to assess genomic variation patterns. The phylogenetics of the 40 samples were clustered into L, GH, GR, O and T types. T types were predominant in Bangkok during the first local outbreak centered at a boxing stadium and entertainment venues in March 2020. Imported cases were infected with various types, including L, GH, GR and O. In southern Thailand introductions of different genotypes were identified at different times. No clinical parameters were significantly associated with differences in genotype. The results indicated local transmission (type T, Spike protein (A829T)) and imported cases (types L, GH, GR and O) during the first wave in Thailand. Genetic and epidemiological data may contribute to national policy formulation, transmission tracking and the implementation of measures to control viral spread.
AD  - Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Department of Microbiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Institute for Urban Disease Control and Prevention, Department of Disease Control, Ministry of Public Health, Bangkok, Thailand.
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Division of Academic Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. Yong.P@chula.ac.th.
AN  - 33024144
AU  - Puenpa, J.
AU  - Suwannakarn, K.
AU  - Chansaenroj, J.
AU  - Nilyanimit, P.
AU  - Yorsaeng, R.
AU  - Auphimai, C.
AU  - Kitphati, R.
AU  - Mungaomklang, A.
AU  - Kongklieng, A.
AU  - Chirathaworn, C.
AU  - Wanlapakorn, N.
AU  - Poovorawan, Y.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73554-7
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Puenpa, Jiratchaya
Suwannakarn, Kamol
Chansaenroj, Jira
Nilyanimit, Pornjarim
Yorsaeng, Ritthideach
Auphimai, Chompoonut
Kitphati, Rungrueng
Mungaomklang, Anek
Kongklieng, Amornmas
Chirathaworn, Chintana
Wanlapakorn, Nasamon
Poovorawan, Yong
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16602. doi: 10.1038/s41598-020-73554-7.
PY  - 2020
SN  - 2045-2322
SP  - 16602
ST  - Molecular epidemiology of the first wave of severe acute respiratory syndrome coronavirus 2 infection in Thailand in 2020
T2  - Scientific reports
TI  - Molecular epidemiology of the first wave of severe acute respiratory syndrome coronavirus 2 infection in Thailand in 2020
VL  - 10
ID  - 7790837
ER  - 

TY  - JOUR
AB  - BACKGROUND In-depth investigations of the safety and immunogenicity of inactivated SARS-CoV-2 vaccines are needed. METHOD In a phase I randomized, double-blinded, and placebo-controlled trial involving 192 healthy adults 18-59 years of age, two injections of three different doses (50 EU, 100 EU and 150 EU) of an inactivated SARS-CoV-2 vaccine or the placebo were administered intramuscularly with a 2- or 4-week interval between the injections. The safety and immunogenicity of the vaccine were evaluated within 28 days. FINDING In this study, 191 subjects assigned to three doses groups or the placebo group completed the 28-day trial. There were 44 adverse reactions within the 28 days, most commonly mild pain and redness at the injection site or slight fatigue, and no abnormal variations were observed in 48 cytokines in the serum samples of immunized subjects. The serum samples diluted from 1:32 to 1:4096 and incubated with the virus did not show antibody-dependent enhancement effects (ADEs) with regard to human natural killer cells, macrophages or dendritic cells. At day 14, the seroconversion rates had reached 92%, 100% and 96% with geometric mean titers (GMTs) of 18.0, 54.5 and 37.1, and at day 28, the seroconversion rates had reached 80%, 96% and 92% with GMTs of 10.6, 15.4 and 19.6in 0, 14 and 0, 28 procedures, respectively. Seroconversion was associated with the synchronous upregulation of ELISA antibodies against the S protein, N protein and virion and a cytotoxic T lymphocyte (CTL) response. Transcriptome analysis shaped the genetic diversity of immune response induced by the vaccine. INTERPRETATION In a population aged 18-59 years, this inactivated SARS-CoV-2 vaccine was safe and immunogenic.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT04412538Funding StatementThis work was supported by National Key R&amp;amp;D Program of China (2020YFC0849700), the Program of Chinese Academy of Medicine Science and the Major science and technology special projects of Yunnan Province.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study protocol was reviewed and approved by the Ethics Committee of the West China Second University Hospital, Sichuan University.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data were available.The raw microarray data were submitted to the National Genomics Data Center (NGDC) and are available (PRJCA003531).
AU  - Pu, Jing
AU  - Yu, Qin
AU  - Yin, Zhifang
AU  - Zhang, Ying
AU  - Li, Xueqi
AU  - Li, Dandan
AU  - Chen, Hongbo
AU  - Long, Runxiang
AU  - Zhao, Zhimei
AU  - Mou, Tangwei
AU  - Zhao, Heng
AU  - Feng, Shiyin
AU  - Xie, Zhongping
AU  - Wang, Lichun
AU  - He, Zhanlong
AU  - Liao, Yun
AU  - Fan, Shengtao
AU  - Yin, Qiongzhou
AU  - Jiang, Ruiju
AU  - Wang, Jianfeng
AU  - Zhang, Lingli
AU  - Li, Jing
AU  - Zheng, Huiwen
AU  - Cui, Pingfang
AU  - Jiang, Guorun
AU  - Guo, Lei
AU  - Xu, Mingjue
AU  - Yang, Huijuan
AU  - Lu, Shan
AU  - Wang, Xuanyi
AU  - Gao, Yang
AU  - Xu, Xingli
AU  - Cai, Linrui
AU  - Zhou, Jian
AU  - Yu, Li
AU  - Chen, Zhuo
AU  - Hong, Chao
AU  - Du, Dan
AU  - Zhao, Hongling
AU  - Li, Yan
AU  - Ma, Kaili
AU  - Ma, Yunfei
AU  - Liu, Donglan
AU  - Yao, Shibao
AU  - Li, Changgui
AU  - Che, Yanchun
AU  - Liu, Longding
AU  - Li, Qihan
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.09.27.20189548
DP  - medRxiv
PY  - 2020
SP  - 2020.09.27.20189548
ST  - An in-depth investigation of the safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (preprint)
T2  - medRxiv
TI  - An in-depth investigation of the safety and immunogenicity of an inactivated SARS-CoV-2 vaccine (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.09.27.20189548.abstract
ID  - 7794724
ER  - 

TY  - JOUR
AB  - Summary As COVID-19 spreads worldwide, governments have been implementing a wide range of measures to contain it, from movement restrictions to economy-wide shutdowns Understanding their impacts is essential to support better policies for countries still experiencing outbreaks or in case of emergence of subsequent pandemic waves Here we show that the cumulative decline in electricity consumption within the five months following the stay-home orders ranges between 3-12% in the most affected EU countries and USA states, except Florida that shows no significant impact Whereas Italy, France, Spain, California, Austria and New York have recovered baseline consumption by the end of July, Great Britain and Germany remain below baseline levels We also show that the relationship between measures stringency and daily decline in electricity consumption is nonlinear These results illustrate the severity of the crisis across countries and can support further research on the effect of specific measures
AU  - Prol, Javier L�Qpez O.
AU  - Sungmin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Impact of COVID-19 measures on short-term electricity consumption in the most affected EU countries and USA states
T2  - iScience
TI  - Impact of COVID-19 measures on short-term electricity consumption in the most affected EU countries and USA states
UR  - https://doi.org/10.1016/j.isci.2020.101639
ID  - 7793149
ER  - 

TY  - JOUR
AB  - Introduction Hydroxychloroquine (HCQ) has shown efficacy against COVID-19 in some but not all studies We hypothesized that systematic review would show HCQ to be: effective against COVID-19, more effective when used earlier, not associated with worsening, and safe Methods We searched PubMed, Cochrane, EmBase, Google Scholar, and Google for all reports on hydroxychloroquine as a treatment for COVID-19 patients This included pre-prints and preliminary reports on larger COVID-19 studies We examined the studies for efficacy, time of administration and safety Results HCQ was found consistently effective against COVID-19 when used early, in the outpatient setting It was found overall effective also including inpatient studies No unbiased study found worse outcomes with HCQ use No mortality or serious safety adverse event was found Conclusions HCQ is consistently effective against COVID-19 when used early in the outpatient setting, it is overall effective against COVID-19, it has not produced worsening, it is safe
AU  - Prodromos, Chadwick
AU  - Rumschlag, Tobias
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Hydroxychloroquine is effective, and consistently so used early, for Covid-19: A systematic review
T2  - New Microbes and New Infections
TI  - Hydroxychloroquine is effective, and consistently so used early, for Covid-19: A systematic review
UR  - https://doi.org/10.1016/j.nmni.2020.100776
ID  - 7793086
ER  - 

TY  - JOUR
AB  - The objective of this study was to analyze how small and medium enterprises (SMEs) cope with environmental changes due to the COVID-19 pandemic by pursuing the business model transformation with the support of digital technologies To achieve the objective, this study used a multiple case study design with qualitative analysis to examine the data obtained from interviews, observation, and field visits Seven manufacturing SMEs from Indonesia were selected using a theoretical sampling technique, with the purpose of achieving some degree of variation to allow us to undertake replication logic Our analysis demonstrates that SMEs adopt a different degree of digital transformations, which can be summarized into three paths, depending on the firms&amp;rsquo;contextual factors First, SMEs with a high level of digital maturity who respond to the challenges by accelerating the transition toward digitalized firms;second, SMEs experiencing liquidity issues but a low level of digital maturity who decide to digitalize the sales function only;and, third, the SMEs that have very limited digital literacy but are supported by a high level of social capital This last group of firms solves the challenges by finding partners who possess excellent digital capabilities The qualitative case study method allows us to conduct in-depth and detailed analysis, but has thin generalizability To address this limitation, future research can use a survey covering various industries to test the proposed theory that has resulted from this study, so that the generalizability can be assured
AU  - Priyono, Anjar
AU  - Moin, Abdul
AU  - Putri, Vera Nur Aini Oktaviani
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Identifying Digital Transformation Paths in the Business Model of SMEs during the COVID-19 Pandemic
T2  - Journal of Open Innovation: Technology, Market, and Complexity
TI  - Identifying Digital Transformation Paths in the Business Model of SMEs during the COVID-19 Pandemic
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813252
ID  - 7793339
ER  - 

TY  - JOUR
AB  - COVID-19 has forced GME programs and medical students to make last-minute adjustments in the resident selection process.
AN  - 33023279
AU  - Price, S.
C1  - 10/7/2020
DA  - Sep 1
DB  - PubMed
DP  - NLM
ET  - 2020/10/08
IS  - 9
J2  - Texas medicine
LA  - eng
N1  - 1938-3223
Price, Sean
Journal Article
United States
Tex Med. 2020 Sep 1;116(9):34-36.
PY  - 2020
SN  - 0040-4470
SP  - 34-36
ST  - A Perfect Match? COVID-19 Forces GME Programs, Med Students to Adjust Resident Selection Process
T2  - Texas medicine
TI  - A Perfect Match? COVID-19 Forces GME Programs, Med Students to Adjust Resident Selection Process
VL  - 116
ID  - 7790926
ER  - 

TY  - JOUR
AB  - COVID-19 reveals longstanding health inequities among minority patients.
AN  - 33023280
AU  - Price, S.
C1  - 10/7/2020
DA  - Sep 1
DB  - PubMed
DP  - NLM
ET  - 2020/10/08
IS  - 9
J2  - Texas medicine
LA  - eng
N1  - 1938-3223
Price, Sean
Journal Article
United States
Tex Med. 2020 Sep 1;116(9):18-23.
PY  - 2020
SN  - 0040-4470
SP  - 18-23
ST  - An Unfortunate Legacy: COVID-19 Reveals Long-Standing Health Inequities
T2  - Texas medicine
TI  - An Unfortunate Legacy: COVID-19 Reveals Long-Standing Health Inequities
VL  - 116
ID  - 7790925
ER  - 

TY  - JOUR
AB  - Catching COVID-19 helped family physician Tim Martindale, MD, find new ways to help his patients.
AN  - 33023281
AU  - Price, S.
C1  - 10/7/2020
DA  - Sep 1
DB  - PubMed
DP  - NLM
ET  - 2020/10/08
IS  - 9
J2  - Texas medicine
LA  - eng
N1  - 1938-3223
Price, Sean
Journal Article
United States
Tex Med. 2020 Sep 1;116(9):30-33.
PY  - 2020
SN  - 0040-4470
SP  - 30-33
ST  - 'This Makes Me Feel More Alive': Catching COVID-19 Helped Physician Find New Ways to Help Patients
T2  - Texas medicine
TI  - 'This Makes Me Feel More Alive': Catching COVID-19 Helped Physician Find New Ways to Help Patients
VL  - 116
ID  - 7790924
ER  - 

TY  - JOUR
AU  - Presant, C. A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Highlights from a Virtual ASCO 2020
T2  - Oncology Issues
TI  - Highlights from a Virtual ASCO 2020
UR  - https://doi.org/10.1080/10463356.2020.1796093
ID  - 7792972
ER  - 

TY  - JOUR
AU  - Prendecki, Maria
AU  - Clarke, Candice
AU  - Medjeral-Thomas, Nicholas
AU  - McAdoo, Stephen P.
AU  - Sandhu, Eleanor
AU  - Peters, James E.
AU  - Thomas, David C.
AU  - Willicombe, Michelle
AU  - Botto, Marina
AU  - Pickering, Matthew C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Temporal changes in complement activation in haemodialysis patients with COVID-19 as a predictor of disease progression
T2  - Clinical Kidney Journal
TI  - Temporal changes in complement activation in haemodialysis patients with COVID-19 as a predictor of disease progression
UR  - https://doi.org/10.1093/ckj/sfaa192
ID  - 7792923
ER  - 

TY  - JOUR
AB  - The pulmonary manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 (COVID-19) are well known. The literature on neurological manifestations and complications in patients with COVID-19 has been increasing but is still sparse. At present, there are only a few reported case reports and clinical studies on neurological manifestations of COVID-19, of which ischemic stroke is one of the most common ones. Coagulopathy and vascular endothelial dysfunction have been proposed as the complications of COVID-19 which can ultimately lead to ischemic stroke. In this case report, we present a case of multifocal ischemic stroke in a patient with COVID-19. This patient had persistent encephalopathy and dysarthria after recovering from hypoxic respiratory failure and subsequently developed ischemic stroke in multiple vascular territories during hospital admission.
AN  - PMC7536517
AU  - Prasad, Apoorv
AU  - Kataria, Saurabh
AU  - Srivastava, Samiksha
AU  - Lakhani, Dhairya A.
AU  - Sriwastava, Shitiz
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.clinimag.2020.09.010
DP  - NLM
J2  - Clin Imaging
KW  - COVID-19, coronavirus disease 2019
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
ATS/IDSA, American Thoracic Society and Infectious Disease Society of America
CT, computed tomography
RT PCR, reverse transcription polymerase chain reaction
L, liters
μl, microliters
MRI, magnetic resonance imaging
ng, nanogram
BUN, blood urea nitrogen
CRP, C-reactive protein
aPTT, activated partial thromboplastin time
DWI, diffusion weighted image
ADC, apparent diffusion coefficient
FLAIR, fluid attenuated inversion recovery
SWI, susceptible weighted imaging
Coronavirus disease 2019
COVID-19
Embolic stroke
Severe acute respiratory syndrome coronavirus 2
SARS-CoV-2
Stroke
MRI brain
LA  - eng
N1  - PMC7536517[pmcid]
S0899-7071(20)30352-1[PII]
PY  - 2020
SN  - 0899-7071
1873-4499
ST  - Multiple embolic stroke on magnetic resonance imaging brain in a COVID-19 case with persistent encephalopathy
T2  - Clinical Imaging
TI  - Multiple embolic stroke on magnetic resonance imaging brain in a COVID-19 case with persistent encephalopathy
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536517/
ID  - 7790661
ER  - 

TY  - JOUR
AB  - Recently in China, a novel coronavirus outbreak took place which caused pneumonia-like symptoms. This coronavirus belongs to the family of SARS and MERS and causes respiratory system disease known as COVID-19. At present we use polymerase chain reaction (PCR) based molecular biology methods for the detection of coronavirus. Other than these PCR based methods, some improved methods also exist such as microarray-based techniques, Real time-quantitative PCR, CRISPR-Cas13 based tools but almost all of the available methods have advantages and disadvantages. There are many limitations associated with this method and hence there is a need for a fast, more sensitive, and specific diagnostic tool which can detect a greater number of samples in less time. Here we have summarised currently available nucleic acid-based diagnostic methods for the detection of coronavirus and the need for developing a better technique for a fast and sensitive detection of coronavirus infections. Nucleic acid based detection tool for SARS-CoV-2.
AD  - Department of Medical Laboratory Sciences, Lovely Professional University, Punjab, 144411, India. prabhakar.iitm@gmail.com.
Department of Medical Laboratory Sciences, Lovely Professional University, Punjab, 144411, India.
AN  - 33025503
AU  - Prabhakar, P. K.
AU  - Lakhanpal, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11033-020-05889-3
DP  - NLM
ET  - 2020/10/08
J2  - Molecular biology reports
KW  - Amplification
Covid-19
Coronavirus
Microarray
Nucleic acid detection
qRT-PCR
LA  - eng
N1  - 1573-4978
Prabhakar, Pranav Kumar
Orcid: 0000-0001-8130-1822
Lakhanpal, Jyoti
Journal Article
Review
Netherlands
Mol Biol Rep. 2020 Oct 6. doi: 10.1007/s11033-020-05889-3.
PY  - 2020
SN  - 0301-4851
ST  - Recent advances in the nucleic acid-based diagnostic tool for coronavirus
T2  - Molecular biology reports
TI  - Recent advances in the nucleic acid-based diagnostic tool for coronavirus
ID  - 7790701
ER  - 

TY  - JOUR
AN  - 33024337
AU  - Pourret, O.
AU  - Saillet, E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/d41586-020-02823-2
DP  - NLM
ET  - 2020/10/08
J2  - Nature
KW  - Education
Media formats
SARS-CoV-2
LA  - eng
N1  - 1476-4687
Pourret, Olivier
Saillet, Elodie
News
England
Nature. 2020 Oct 6. doi: 10.1038/d41586-020-02823-2.
PY  - 2020
SN  - 0028-0836
ST  - Wear your mask, but think about deaf students
T2  - Nature
TI  - Wear your mask, but think about deaf students
ID  - 7790822
ER  - 

TY  - JOUR
AD  - Skin Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clinical Research Development Unit, Shohada-e Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AN  - 33021332
AU  - Pourani, M. R.
AU  - Nasiri, S.
AU  - Abdollahimajd, F.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/dth.14367
DP  - NLM
ET  - 2020/10/07
J2  - Dermatologic therapy
KW  - Covid-19
Contact urticaria
Coronavirus
Healthcare workers
LA  - eng
N1  - 1529-8019
Pourani, Mohammad Reza
Orcid: 0000-0003-3222-7528
Nasiri, Soheila
Abdollahimajd, Fahimeh
Orcid: 0000-0002-9463-0665
Letter
United States
Dermatol Ther. 2020 Oct 6:e14367. doi: 10.1111/dth.14367.
PY  - 2020
SN  - 1396-0296
SP  - e14367
ST  - Prevalence of hand contact urticaria and related risk factors among healthcare workers (HCWs) during the COVID-19 pandemic: a self-reported assessment
T2  - Dermatologic therapy
TI  - Prevalence of hand contact urticaria and related risk factors among healthcare workers (HCWs) during the COVID-19 pandemic: a self-reported assessment
ID  - 7791039
ER  - 

TY  - JOUR
AB  - The dynamics of COVID-19 is investigated with regard to complex contributions of the omitted factors For this purpose, we use a fractional order SEIR model which allows us to calculate the number of infections considering the chaotic contributions into susceptible, exposed, infectious and removed number of individuals We check our model on Wuhan, China-2019 and South Korea underlying the importance of the chaotic contribution, and then we extend it to Italy and the USA Results are of great guiding significance to promote evidence-based decisions and policy
AU  - Postavaru, O.
AU  - Anton, S. R.
AU  - Toma, A.
C1  - 10/7/2020
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
ST  - COVID-19 pandemic and chaos theory
T2  - Mathematics and Computers in Simulation
TI  - COVID-19 pandemic and chaos theory
UR  - https://doi.org/10.1016/j.matcom.2020.09.029
ID  - 7793107
ER  - 

TY  - JOUR
AD  - Aerospace Medical Association, Alexandria, Virginia.
International Airline Medical Association, Alexandria, Virginia.
International Air Transport Association (IATA), Geneva, Switzerland.
AN  - 33022035
AU  - Pombal, R.
AU  - Hosegood, I.
AU  - Powell, D.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1001/jama.2020.19108
DP  - NLM
ET  - 2020/10/07
J2  - Jama
LA  - eng
N1  - 1538-3598
Pombal, Rui
Hosegood, Ian
Powell, David
Journal Article
United States
JAMA. 2020 Oct 1. doi: 10.1001/jama.2020.19108.
PY  - 2020
SN  - 0098-7484
ST  - Risk of COVID-19 During Air Travel
T2  - Jama
TI  - Risk of COVID-19 During Air Travel
ID  - 7790985
ER  - 

TY  - JOUR
AB  - Computer Tomography (CT) imaging of the chest is a valid diagnosis tool to detect COVID-19 promptly and to control the spread of the disease In this work we propose a light Convolutional Neural Network (CNN) design, based on the model of the SqueezeNet, for the efficient discrimination of COVID-19 CT images with respect to other community-acquired pneumonia and/or healthy CT images The architecture allows to an accuracy of 85 03% with an improvement of about 3 2% in the first dataset arrangement and of about 2 1% in the second dataset arrangement The obtained gain, though of low entity, can be really important in medical diagnosis and, in particular, for Covid-19 scenario Also the average classification time on a high-end workstation, 1 25 seconds, is very competitive with respect to that of more complex CNN designs, 13 41 seconds, witch require pre-processing The proposed CNN can be executed on medium-end laptop without GPU acceleration in 7 81 seconds: this is impossible for methods requiring GPU acceleration The performance of the method can be further improved with efficient pre-processing strategies for witch GPU acceleration is not necessary
AU  - Polsinelli, Matteo
AU  - Cinque, Luigi
AU  - Placidi, Giuseppe
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A Light CNN for detecting COVID-19 from CT scans of the chest
T2  - Pattern Recognition Letters
TI  - A Light CNN for detecting COVID-19 from CT scans of the chest
UR  - https://doi.org/10.1016/j.patrec.2020.10.001
ID  - 7793082
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic continues to ravage the world, with the United States being highly affected. A vaccine provides the best hope for a permanent solution to controlling the pandemic. However, to be effective, a vaccine must be accepted and used by a large majority of the population. The aim of this study was to understand the attitudes towards and obstacles facing vaccination with a potential COVID-19 vaccine. To measure these attitudes a survey was administered to 316 respondents across the United States by a survey corporation. Structural equation modeling was used to analyze the relationships of several factors with attitudes toward potential COVID-19 vaccination. Prior vaccine usage and attitudes predicted attitudes towards COVID-19 vaccination. Assessment of the severity of COVID-19 for the United States was also predictive. Approximately 68% of all respondents were supportive of being vaccinated for COVID-19, but side effects, efficacy and length of testing remained concerns. Longer testing, increased efficacy and development in the United States were significantly associated with increased vaccine acceptance. Messages promoting COVID-19 vaccination should seek to alleviate the concerns of those who are already vaccine-hesitant. Messaging directed at the benefits of vaccination for the United States as a country would address the second predictive factor. Enough time should be taken to allay concerns about both short- and long-term side effects before a vaccine is released.
AD  - Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA.
Department of Biology, Brigham Young University, Provo, UT 84602, USA.
AN  - 33022917
AU  - Pogue, K.
AU  - Jensen, J. L.
AU  - Stancil, C. K.
AU  - Ferguson, D. G.
AU  - Hughes, S. J.
AU  - Mello, E. J.
AU  - Burgess, R.
AU  - Berges, B. K.
AU  - Quaye, A.
AU  - Poole, B. D.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/vaccines8040582
DP  - NLM
ET  - 2020/10/08
IS  - 4
J2  - Vaccines
KW  - Covid-19
SARS-CoV-2
vaccine attitudes
vaccine development
vaccine hesitancy
of the study
in the collection, analyses, or interpretation of data
in the writing
of the manuscript, or in the decision to publish the results.
LA  - eng
N1  - Pogue, Kendall
Jensen, Jamie L
Stancil, Carter K
Ferguson, Daniel G
Hughes, Savannah J
Mello, Emily J
Burgess, Ryan
Berges, Bradford K
Quaye, Abraham
Poole, Brian D
Journal Article
Switzerland
Vaccines (Basel). 2020 Oct 3;8(4):E582. doi: 10.3390/vaccines8040582.
PY  - 2020
SN  - 2076-393X (Print)
2076-393x
ST  - Influences on Attitudes Regarding Potential COVID-19 Vaccination in the United States
T2  - Vaccines
TI  - Influences on Attitudes Regarding Potential COVID-19 Vaccination in the United States
VL  - 8
ID  - 7790933
ER  - 

TY  - JOUR
AB  - In contrast to blood and urine samples, breath is invisible and ubiquitous in the environment. Different precautions are now necessary beyond the usual 'Universal Precautions'. In the era of COVID-19, breath (especially the aerosol fraction) can no longer be considered as harmless in the clinic or laboratory. As Journal of Breath Research is a primary resource for breath-related research, we (the editors) are presently developing safety guidance applicable to all breath research , not just for those projects that involve known COVID-19 infected subjects. We are starting this process by implementing requirements on reporting safety precautions in research papers and notes. This editorial announces that authors of all new submissions to JBR henceforth must state clearly the procedures undertaken for assuring laboratory and clinical safety, much like the existing requirements for disclosing Ethics Committee or Institutional Review Board protocols for studies on human subjects. In the following, we additionally make some recommendations based on best practices drawn from our experience and input from the JBR Editorial Board.
AD  - Editor-in-Chief, Journal of Breath Research.
AN  - 33021207
AU  - Pleil, J. D.
AU  - Beauchamp, J. D.
AU  - Dweik, R. A.
AU  - Risby, T. H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1088/1752-7163/abb99a
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Journal of breath research
LA  - eng
N1  - 1752-7163
Pleil, Joachim D
Beauchamp, Jonathan D
Dweik, Raed A
Risby, Terence H
Journal Article
England
J Breath Res. 2020 Oct 6;14(4):040202. doi: 10.1088/1752-7163/abb99a.
PY  - 2020
SN  - 1752-7155
SP  - 040202
ST  - Breath research in times of a global pandemic and beyond: the game changer
T2  - Journal of breath research
TI  - Breath research in times of a global pandemic and beyond: the game changer
VL  - 14
ID  - 7791041
ER  - 

TY  - JOUR
AB  - Background In Italy, the National surveillance of all SARS-CoV-2 laboratory-confirmed cases was established on 27 February 2020, building on a previously existing laboratory network focused on suspected and confirmed COVID-19 severe respiratory infections Methods The integrated epidemiological and microbiological surveillance systematically collects and analyzes information on all SARS-CoV-2 confirmed cases Regional reference laboratories analyze samples, inform Local Health Authorities of the results and coordinate data flow between cases, hospitals and GPs Regions provide data through a web interface connected to a dedicated IT platform or by sending a dataset The Infectious Diseases Department at Istituto Superiore di Sanità processes and analyzes data, producing reports on a daily and weekly basis, as well as indicator analyses based on the monitoring of “phase 2�?(post-lockdown) Moreover, mathematical models are constructed daily on these data Results Since the beginning of the epidemic, the surveillance system recorded 238 901 COVID-19 cases and 33 369 deaths on 19-6 Main challenges were the coordination of different actors, hampered by the decentralization of health to the Regions, and data interpretation due to the delay in the detection of cases and deaths Besides the COVID-19 surveillance, we planned ad hoc studies and periodic surveys: health care workers, long term care facilities, clusters and red zones, health system resilience monitoring Conclusions COVID-19 surveillance is an essential tool to inform the public about the epidemic trend and provide support to public health response We urge upon all relevant stakeholders a reflection on important issues such as defining ethical boundaries for data scavenging during emergencies, how existing laws on data protection could affect record linkage among different existing datasets to assess diseases and other variables for correlation, or which ethical approaches on open data would apply to our setting Key messages A strong and adequately funded public health system in place allows an efficient response in times of epidemics both in terms of data collection and public health response, policy and decisions COVID-19 epidemic showed us all the limits of a regionalized health system which was not entirely coordinated between periphery and central institutions
AU  - Pezzotti, P.
AU  - Punzo, O.
AU  - Bella, A.
AU  - Del Manso, M.
AU  - Urdiales, A. M.
AU  - Fabiani, M.
AU  - Ciervo, A.
AU  - Andrianou, X.
AU  - Riccardo, F.
AU  - Stefanelli, P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The challenges of the outbreak: the Italian COVID-19 integrated surveillance system
T2  - European Journal of Public Health
TI  - The challenges of the outbreak: the Italian COVID-19 integrated surveillance system
UR  - https://doi.org/10.1093/eurpub/ckaa165.356
ID  - 7792913
ER  - 

TY  - JOUR
AB  - Résumé Objectifs: Le coronavirus SARS-CoV-2 mis en évidence en fin d’année 2019 en Chine a atteint tous les continents, avec plus de 28 millions de cas déclarés dont plus de 920�?00 déc؈s au 17/9/2020 Le plus souvent à l’origine d’un syndrome infectieux bénin, associant à différents degrés des symptômes (fi؈vre, toux, myalgies, céphalées et éventuels troubles digestifs), voire totalement asymptomatique, le SARS-CoV-2 peut �^tre à l’origine de pathologies pulmonaires graves et parfois de déc؈s Méthode: Au vu de l’évolution de l’épidémie, le Coll؈ge National Des Gynécologues Obstétriciens Français a décidé de mettre à jours les avis émis précédemment Pour cela, le m�^me groupe d’experts, a été sollicité avec réalisation d’une revue de la littérature et prise en compte des avis de la Direction Générale de la Santé, la Haute Autorité de Santé, du Haut Conseil de Santé Publique Résultats: Les données pendant la grossesse sont plus nombreuses et plus précises Les données publiées semblent montrer que les symptômes chez la femmes enceintes sont les m�^mes que ceux de la population générale et qu’un sur risque existe chez la femme enceinte particuli؈rement au troisi؈me trimestre Un cas de transmission materno-fœtale intra utérine a été formellement identifié Une prématurité induite et des cas de détresses respiratoires chez les nouveau-nés de m؈res infectées ont été décrits Conclusion: A la lumi؈re des nouvelles données, nous proposons une actualisation des recommandations de prise en charge Ces propositions peuvent encore évoluer avec l’avancée de la pandémie et de potentielles nouvelles connaissances chez la femme enceinte Objectives: The coronavirus SARS-CoV-2 identified late 2019 in China had spread across all continents In the majority of cases, patients have mild symptoms (fever, cough, myalgia, headache, some digestive disorders) or are asymptomatic, however it can cause serious lung diseases and lead to death On September 2020, over 28 million people have been infected with over 920,000 deaths Methods: In view of the evolution of the epidemic the French National College of Obstetricians and Gynecologists has decided to update the recommendations previously issued To do this, the same group of experts was called upon to carry out a review of the literature and take into account the opinions of the General Directorate of Health (DGS), the “Haute Autorité de Santé�?(HAS) and the “Haut Conseil de santé Publique�?(HCSP) Results: The data on consequences during pregnancy have accumulated The symptoms in pregnant women appear to be similar to those of the general population, but an increased risk of respiratory distress exists in pregnant women especially in the third trimester A case of intrauterine maternal-fetal transmission has been clearly identified Induced prematurity and cases of respiratory distress in newborns of infected mothers have been described Conclusion: In light of the new data, we propose updated recommendations These proposals may continue to evolve in view of the pandemic and of advances in studies in pregnant women
AU  - Peyronnet, Violaine
AU  - Sibiude, Jeanne
AU  - Huissoud, Cyril
AU  - Lescure, François-Xavier Lucet
AU  - Jean-Christophe, Mandelbrot
AU  - Laurent, Nisand
AU  - Israel, Belaish-Allart
AU  - Joëlle, Vayssi؈re Christophe
AU  - Yazpandanah, Yazdan
AU  - Luton, Dominique
AU  - Picone, Olivier
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Infection par le SARS-CoV-2 chez les femmes enceintes. Actualisation de l’état des connaissances et de la proposition de prise en charge. CNGOF
T2  - Gynécologie Obstétrique Fertilité & Sénologie 
TI  - Infection par le SARS-CoV-2 chez les femmes enceintes. Actualisation de l’état des connaissances et de la proposition de prise en charge. CNGOF
UR  - https://doi.org/10.1016/j.gofs.2020.10.001
ID  - 7793173
ER  - 

TY  - JOUR
AB  - The WHO has highlighted the technical challenges of assessing immunity status, cautioning against immunity passports Similarly, the ECDC indicated that “current scientific knowledge that exists on the immunological response to SARS-CoV-2 (quality, quantity and duration of human antibodies) or the available testing methods (laboratory based and point-of-care)�?does not support their use Accordingly, the European Commission has emphasised the risks compulsory testing, noting that “border control [is not] an effective measure to limit the transmission of the virus, while the Council of Europe raises awareness of the interference of SARS-CoV-2 measures on human rights, underlining that “the major social, political and legal challenge facing our Member States will be their ability to respond to this crisis effectively, whilst ensuring that the measures they take do not undermine our genuine long-term interest in safeguarding Europe&#039;s founding values of human rights, democracy and the rule of law�?
AU  - Petelos, E.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Public health law and COVID-19: Human rights and global health security
T2  - European Journal of Public Health
TI  - Public health law and COVID-19: Human rights and global health security
UR  - https://doi.org/10.1093/eurpub/ckaa165.501
ID  - 7792911
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) has spread worldwide, resulting in significant morbidity and mortality Histopathological findings are essential in understanding its pathogenesis and we present our findings from postmortem core needle biopsies in an attempt to share information that may shed some light on this severe pandemic Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sof�Ta Hospital (Madrid) were studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry Results were compared with other reported cases All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described The histopathology of organs affected by COVID-19 is vital to the understanding of this disease and its sequelae Resumen Hallazgos patol�Qgicos multi-org֙nicos asociados a COVID-19 a través de biopsias con aguja gruesa postmortem y revisi�Qn de la literatura actual La enfermedad de coronavirus 2019 (COVID-19) ha afectado de forma mundial causando intensa morbimortalidad Los hallazgos patol�Qgicos son claves para entender su patogénesis A través de biopsias con aguja gruesa postmortem, intentamos responder a las inc�Qgnitas que giran en torno a la severidad de ésta infecci�Qn Se enviaron muestras de cuatro pacientes COVID-19 positivos al servicio de Anatom�Ta Patol�Qgica del Hospital Infanta Sof�Ta (Madrid) en los meses de Abril y Mayo 2020 Se estudiaron a través de distintas técnicas y los resultados se compararon con la literatura, buscando similitudes y peculiaridades Todos los pacientes ten�Tan un diagn�Qstico de neumon�Ta Las biopsias mostraron daño pulmonar en la mayor�Ta El resto de �Qrganos estudiados fueron: coraz�Qn, h�Tgado, bazo y riñ�Qn Se encontraron caracter�Tsticas distintivas en muchos, las cuales fueron descritas exhaustivamente En conclusi�Qn, el an֙lisis microsc�Qpico de �Qrganos afectados por COVID-19 es importante para comprender ésta enfermedad y sus posibles consecuencias
AU  - Pessolani, Tais Gonz֙lez Fern֙ndez de Legaria Marta Muñ�Qz Apell֙niz Margarita Elices
AU  - Moreno, Silvia Salinas
AU  - Cortés, Mar�Ta del Mar Lorido S֙nchez Sagrario Garc�Ta
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Multi-organ pathological findings associated with COVID-19 in postmortem needle core biopsies in four patients and a review of the current literature (Hallazgos patol�Qgicos multi-org֙nicos asociados a COVID-19 a través de biopsias con aguja gruesa postmortem y revisi�Qn de la literatura actual)
T2  - Revista Española de Patolog�Ta
TI  - Multi-organ pathological findings associated with COVID-19 in postmortem needle core biopsies in four patients and a review of the current literature (Hallazgos patol�Qgicos multi-org֙nicos asociados a COVID-19 a través de biopsias con aguja gruesa postmortem y revisi�Qn de la literatura actual)
UR  - https://doi.org/10.1016/j.patol.2020.09.003
ID  - 7793083
ER  - 

TY  - JOUR
AB  - BACKGROUND: Classic epidemic curves - counts of daily events or cumulative events over time -emphasise temporal changes in the growth or size of epidemic outbreaks. Like any graph, these curves have limitations: they are impractical for comparisons of large and small outbreaks or of asynchronous outbreaks, and they do not display the relative growth rate of the epidemic. Our aim was to propose two additional graphical displays for the monitoring of epidemic outbreaks that overcome these limitations. METHODS: The first graph shows the growth of the epidemic as a function of its size; specifically, the logarithm of new cases on a given day, N(t), is plotted against the logarithm of cumulative cases C(t). Logarithm transformations facilitate comparisons of outbreaks of different sizes, and the lack of a time scale overcomes the need to establish a starting time for each outbreak. Notably, on this graph, exponential growth corresponds to a straight line with a slope equal to one. The second graph represents the logarithm of the relative rate of growth of the epidemic over time; specifically, log(10)(N(t)/C(t-1)) is plotted against time (t) since the 25th event. We applied these methods to daily death counts attributed to COVID-19 in selected countries, reported up to June 5, 2020. RESULTS: In most countries, the log(N) over log(C) plots showed initially a near-linear increase in COVID-19 deaths, followed by a sharp downturn. They enabled comparisons of small and large outbreaks (e.g., Switzerland vs UK), and identified outbreaks that were still growing at near-exponential rates (e.g., Brazil or India). The plots of log(10)(N(t)/C(t-1)) over time showed a near-linear decrease (on a log scale) of the relative growth rate of most COVID-19 epidemics, and identified countries in which this decrease failed to set in in the early weeks (e.g., USA) or abated late in the outbreak (e.g., Portugal or Russia). CONCLUSIONS: The plot of log(N) over log(C) displays simultaneously the growth and size of an epidemic, and allows easy identification of exponential growth. The plot of the logarithm of the relative growth rate over time highlights an essential parameter of epidemic outbreaks.
AD  - Division of clinical epidemiology, Geneva University Hospitals, and Faculty of medicine, University of Geneva, Geneva, Switzerland. thomas.perneger@hcuge.ch.
Teem Photonics, 61 Chemin du Vieux Ch�^ne, 38240, Meylan, France.
Neel Institute, Université Grenoble Alpes, Grenoble, France.
Institute of Environmental Geosciences, Université Grenoble Alpes, Grenoble, France.
Division of clinical epidemiology, Geneva University Hospitals, and Faculty of medicine, University of Geneva, Geneva, Switzerland.
AN  - 33023505
AU  - Perneger, T.
AU  - Kevorkian, A.
AU  - Grenet, T.
AU  - Gallée, H.
AU  - Gayet-Ageron, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s12874-020-01122-8
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMC medical research methodology
KW  - Covid-19
Epidemic curve
Growth rate
LA  - eng
N1  - 1471-2288
Perneger, Thomas
Orcid: 0000-0001-5667-0968
Kevorkian, Antoine
Grenet, Thierry
Gallée, Hubert
Gayet-Ageron, Ang؈le
Journal Article
England
BMC Med Res Methodol. 2020 Oct 6;20(1):248. doi: 10.1186/s12874-020-01122-8.
PY  - 2020
SN  - 1471-2288
SP  - 248
ST  - Alternative graphical displays for the monitoring of epidemic outbreaks, with application to COVID-19 mortality
T2  - BMC medical research methodology
TI  - Alternative graphical displays for the monitoring of epidemic outbreaks, with application to COVID-19 mortality
VL  - 20
ID  - 7790906
ER  - 

TY  - JOUR
AN  - 33024333
AU  - Peeples, L.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1038/d41586-020-02801-8
DP  - NLM
ET  - 2020/10/08
IS  - 7828
J2  - Nature
KW  - Diseases
Epidemiology
Fluid dynamics
SARS-CoV-2
LA  - eng
N1  - 1476-4687
Peeples, Lynne
News
England
Nature. 2020 Oct;586(7828):186-189. doi: 10.1038/d41586-020-02801-8.
PY  - 2020
SN  - 0028-0836
SP  - 186-189
ST  - Face masks: what the data say
T2  - Nature
TI  - Face masks: what the data say
VL  - 586
ID  - 7790823
ER  - 

TY  - GEN
AN  - NCT04578210
AU  - Paz, Instituto de Investigaci�Qn Hospital Universitario La
AU  - Madrid, Universidad Autonoma de
AU  - Elche, Universidad Miguel Hernandez de
AU  - BioCruces, Asociaci�Qn Instituto de Investigaci�Qn Sanitaria
AU  - Valenciana, Fundaci�Qn para el Fomento de la Investigaci�Qn Sanitaria y Biomédica de la Comunitat
C1  - 10/7/2020
DA  - September 4
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Corona Virus Infection
N1  - No Results Available
Biological: T memory cells and NK cells
Occurrence of DLTs in all patients during the study treatment, until 21 days after cell infusion and the MTD
All
Phase 1|Phase 2
58
Other
Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Treatment
RELEASE
March 2021
PB  - https://ClinicalTrials.gov/show/NCT04578210
PY  - 2020
ST  - release
T2  - ClinicalTrials
TI  - Safety Infusion of NatuRal KillEr celLs or MEmory T Cells as Adoptive Therapy in COVID-19 pnEumonia or Lymphopenia (WHO)
UR  - https://ClinicalTrials.gov/show/NCT04578210
ID  - 7794704
ER  - 

TY  - JOUR
AD  - School of Health and Related Research, University of Sheffield, Sheffield S1 4DA, UK.
AN  - 33023934
AU  - Payne, N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/bmj.m3889
DP  - NLM
ET  - 2020/10/08
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Payne, Nick
Letter
England
BMJ. 2020 Oct 6;371:m3889. doi: 10.1136/bmj.m3889.
PY  - 2020
SN  - 0959-8138
SP  - m3889
ST  - Covid-19 elimination: consider population level effects of vaccine
T2  - BMJ
TI  - Covid-19 elimination: consider population level effects of vaccine
VL  - 371
ID  - 7790861
ER  - 

TY  - JOUR
AB  - The key aspects to be discussed by this panelist are the role of vaccines in the support of globalization and the life style of global village, and the current status of coronavirus vaccines and future challenges of implementation
AU  - Pavlakis, G.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Vaccines in support of globalisation: the current status of coronavirus and future implementation challenges
T2  - European Journal of Public Health
TI  - Vaccines in support of globalisation: the current status of coronavirus and future implementation challenges
UR  - https://doi.org/10.1093/eurpub/ckaa165.499
ID  - 7792912
ER  - 

TY  - JOUR
AB  - I analyze a simplified SIR model developed from a paper written by Gyan Bhanot and Charles de Lisi in May of 2020 to find the successes and limitations of their predictions. In particular, I study the predicted cases and deaths fitted to data from March and its potential application to data in September. The data is observed to fit the model as predicted until around 150 days after December 31, 2019, after which many countries lift their lockdowns and begin to reopen. A plateau in cases followed by an increase approximately 1.5 months after is also observed. In terms of deaths, the data fits the shape of the model, but the model mostly underestimates the death toll after around 160 days. An analysis of the residuals is provided to locate the precise date of the departure of each country from its accepted data estimates and test each data point to its predicted value using a Z-test to determine whether each observation can fit the given model. The observed behavior is matched to policy measures taken in each country to attach an explanation to these observations. I notice that an international reopening results in a sharp increase in cases, and aim to plot this new growth in cases and predict when the pandemic will end for each country.Competing Interest StatementThe authors have declared no competing interest.Funding StatementnoneAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:noneAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data used in this paper were all derived from public sources. Links to these data are included in the paper. The main data source is taken from https://ourworldindata.org/coronavirus-source-data. The R code used to analyze the data along with all data files will be provided on request - email: jaypatwardhan3@gmail.com.
AU  - Patwardhan, Jay
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206359
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206359
ST  - PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMIC AFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL (preprint)
T2  - medRxiv
TI  - PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMIC AFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206359.abstract
ID  - 7794739
ER  - 

TY  - JOUR
AB  - The year 2020 brought the news of the emergence of a new respiratory disease (COVID-19) from Wuhan, China The disease is now a global pandemic and is caused by a virus named SARS-CoV-2 by international bodies Important viral transmission sources include human contact, respiratory droplets and aerosols, and through contact with contaminated objects However, viral shedding in feces and urine by COVID-19-afflicted patients raises concerns about SARS-CoV-2 entering aquatic systems Recently, targeted SARS-CoV-2 genome fragments have been successfully detected in wastewater, sewage sludge and river waters around the world Wastewater-based epidemiology (WBE) studies can provide early detection and assessment of COVID-19 transmission and the growth of active cases within given wastewater catchment areas WEB surveillance&#039;s ability to detect the growth of cases was demonstrated Was this science applied throughout the world as this pandemic spread throughout the globe? Wastewater treatment efficacy for SARS-CoV-2 removal and risk assessments associated with treated water are reported Disinfection strategies using chemical disinfectants, heat and radiation for deactivating and destroying SARS-CoV-2 are explained Analytical methods of SARS-CoV-2 detection are covered This review provides a more complete overview of the present status of SARS-CoV-2 and its consequences in aquatic systems So far, WBE programs have not yet served to provide the early alerts to authorities that they have the potential to achieve This would be desirable in order to activate broad public health measures at earlier stages of local and regional stages of transmission
AU  - Patel, Manvendra
AU  - Chaubey, Abhishek Kumar
AU  - Pittman, Charles U.
AU  - Mlsna, Todd
AU  - Mohan, Dinesh
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Coronavirus (SARS-CoV-2) in the Environment: Occurrence, Persistence, Analysis in Aquatic Systems and Possible Management
T2  - Science of Total Environment
TI  - Coronavirus (SARS-CoV-2) in the Environment: Occurrence, Persistence, Analysis in Aquatic Systems and Possible Management
UR  - https://doi.org/10.1016/j.scitotenv.2020.142698
ID  - 7793052
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019, is a respiratory virus primarily transmitted person to person through inhalation of droplets or aerosols, laden with viral particles. However, as recent studies have shown, virions can remain infectious for up to 72 h on surfaces, which can lead to transmission through contact. Thus, a comprehensive study was conducted to determine the efficiency of protocols to recover SARS-CoV-2 from surfaces in built environments. This end-to-end (E2E) study showed that the effective combination for monitoring SARS-CoV-2 on surfaces includes using an Isohelix swab collection tool, DNA/RNA Shield as a preservative, an automated system for RNA extraction, and reverse transcriptase quantitative PCR (RT-qPCR) as the detection assay. Using this E2E approach, this study showed that, in some cases, noninfectious viral fragments of SARS-CoV-2 persisted on surfaces for as long as 8 days even after bleach treatment. Additionally, debris associated with specific built environment surfaces appeared to inhibit and negatively impact the recovery of RNA; Amerstat demonstrated the highest inhibition (90%) when challenged with an inactivated viral control. Overall, it was determined that this E2E protocol required a minimum of 1,000 viral particles per 25 cm(2) to successfully detect virus from test surfaces. Despite our findings of viral fragment longevity on surfaces, when this method was employed to evaluate 368 samples collected from various built environmental surfaces, all samples tested negative, indicating that the surfaces were either void of virus or below the detection limit of the assay.IMPORTANCE The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (the virus responsible for coronavirus disease 2019 [COVID-19]) pandemic has led to a global slowdown with far-reaching financial and social impacts. The SARS-CoV-2 respiratory virus is primarily transmitted from person to person through inhalation of infected droplets or aerosols. However, some studies have shown that virions can remain infectious on surfaces for days and can lead to human infection from contact with infected surfaces. Thus, a comprehensive study was conducted to determine the efficiency of protocols to recover SARS-CoV-2 from surfaces in built environments. This end-to-end study showed that the effective combination for monitoring SARS-CoV-2 on surfaces required a minimum of 1,000 viral particles per 25 cm(2) to successfully detect virus from surfaces. This comprehensive study can provide valuable information regarding surface monitoring of various materials as well as the capacity to retain viral RNA and allow for effective disinfection.
AD  - NASA Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA.
Vermont Integrative Genomics Resource, Larner College of Medicine, The University of Vermont, Burlington, Vermont, USA.
ZIN Technologies Inc., Middleburg Heights, Ohio, USA.
Biotia, New York, New York, USA.
SUNY Downstate Health Sciences University, Brooklyn, New York, USA.
Weill Medical College of Cornell University, New York, New York, USA.
Institute of Medical Virology and Epidemiology of Viral Diseases, University Hospital, Tubingen, Germany.
NASA Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, USA kasthuri.j.venkateswaran@jpl.nasa.gov.
AN  - 33024053
AU  - Parker, C. W.
AU  - Singh, N.
AU  - Tighe, S.
AU  - Blachowicz, A.
AU  - Wood, J. M.
AU  - Seuylemezian, A.
AU  - Vaishampayan, P.
AU  - Urbaniak, C.
AU  - Hendrickson, R.
AU  - Laaguiby, P.
AU  - Clark, K.
AU  - Clement, B. G.
AU  - O'Hara, N. B.
AU  - Couto-Rodriguez, M.
AU  - Bezdan, D.
AU  - Mason, C. E.
AU  - Venkateswaran, K.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1128/mSystems.00771-20
DP  - NLM
ET  - 2020/10/08
IS  - 5
J2  - mSystems
KW  - Covid-19
Lamp
RT-qPCR
SARS-CoV-2
built environments
coronavirus
end-to-end
fomites
high-touch surface
surface sampling
LA  - eng
N1  - Parker, Ceth W
Orcid: 0000-0002-4328-490x
Singh, Nitin
Orcid: 0000-0001-5344-1190
Tighe, Scott
Orcid: 0000-0002-3988-0741
Blachowicz, Adriana
Orcid: 0000-0001-9027-5670
Wood, Jason M
Orcid: 0000-0002-0847-4695
Seuylemezian, Arman
Vaishampayan, Parag
Urbaniak, Camilla
Hendrickson, Ryan
Laaguiby, Pheobe
Clark, Kevin
Clement, Brian G
Orcid: 0000-0003-4591-014x
O'Hara, Niamh B
Couto-Rodriguez, Mara
Bezdan, Daniela
Mason, Christopher E
Venkateswaran, Kasthuri
Orcid: 0000-0002-6742-0873
Journal Article
United States
mSystems. 2020 Oct 6;5(5):e00771-20. doi: 10.1128/mSystems.00771-20.
PY  - 2020
SN  - 2379-5077 (Print)
2379-5077
ST  - End-to-End Protocol for the Detection of SARS-CoV-2 from Built Environments
T2  - mSystems
TI  - End-to-End Protocol for the Detection of SARS-CoV-2 from Built Environments
VL  - 5
ID  - 7790851
ER  - 

TY  - JOUR
AU  - Parisi, Simone
AU  - Borrelli, Richard
AU  - Bianchi, Sabina
AU  - Fusaro, Enrico
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Viral arthritis and COVID-19
T2  - Lancet Rheumatology
TI  - Viral arthritis and COVID-19
UR  - https://doi.org/10.1016/S2665-9913(20)30348-9
ID  - 7793006
ER  - 

TY  - GEN
AN  - NCT04578509
AU  - Paris, Assistance Publique - Hôpitaux de
C1  - 10/7/2020
DA  - October
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - SARS-CoV-2 Infection|COVID-19
N1  - No Results Available
Diagnostic Test: Nasopharyngeal swab|Diagnostic Test: Saliva sample|Other: Data collection
Positivity of RT-PCR on nasopharyngeal swab for the SARS-CoV-2 virus|Positivity of RT-PCR on saliva sample for the SARS-CoV-2 virus|Positivity of new detection approach on saliva sample for the SARS-CoV-2 virus|Practicability to samples|Practicability to premises|Practicability to interpretation|Practicability to render time|IgG Antibody detection in saliva|IgM Antibody detection in saliva|IgA Antibody detection in saliva|Patient tolerance of the salivary self-sampling|Operator tolerance of the salivary self-sampling|Cost of each approach
All
2750
Other
Observational Model: Cohort|Time Perspective: Prospective
APHP200960|2020-A02431-38
June 2021
PB  - https://ClinicalTrials.gov/show/NCT04578509
PY  - 2020
ST  - salicov
T2  - ClinicalTrials
TI  - Evaluation of a Screening Program for SARS-CoV-2 Infection in the General Population Based on the Use of New Detection Approaches or for Diagnostic Orientation on Saliva
UR  - https://ClinicalTrials.gov/show/NCT04578509
ID  - 7794695
ER  - 

TY  - JOUR
AB  - This study aims to discuss the prevalence of COVID-19 in U.S, Italy, Spain , France and China, where the virus spreads most rapidly and causes tragic outcomes. Thereafter, we present new insights of existence and uniqueness solutions of the 2019-nCoV models via fractional and fractal-fractional operators by using fixed point methods.
AN  - PMC7536175
AU  - Panda, Sumati Kumari
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.rinp.2020.103433
DP  - NLM
J2  - Results Phys
KW  - Fractional integral for Mittag-Leffler kernel
Fractal-fractional integral for Mittag-Leffler kernel
Fixed point
2019-nCoV model
LA  - eng
N1  - PMC7536175[pmcid]
S2211-3797(20)31899-4[PII]
PY  - 2020
SN  - 2211-3797
SP  - 103433
ST  - Applying fixed point methods and fractional operators in the modelling of novel coronavirus 2019-nCoV/SARS-CoV-2
T2  - Results in Physics
TI  - Applying fixed point methods and fractional operators in the modelling of novel coronavirus 2019-nCoV/SARS-CoV-2
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536175/
ID  - 7790658
ER  - 

TY  - JOUR
AB  - In this paper, a novel piezoelectric sensor is presented for patient&#039;s breath monitoring applications Breath rate monitoring is important especially for the new coronavirus patients In this work, a piezoelectric sensor is designed in the form of a vertex-attached triangular beam made of Polyvinylidene fluoride (PVDF) and Polydimethylsiloxane (PDMS) It exploits chest displacement to distinguish breathing vibrations The device shape and dimensions have been designed for low frequency operation The output respiration signal is amplified using a low power charge amplifier circuit The sensor can be placed in a vest and fastened as a belt, or be attached to the chest by a tape A low pass filter is used to eliminate the noise from the environment and body movement Among the most important features are high accuracy, low resonance frequency to distinguish chest movement, low weight, low cost, portability, and reliability Simulation of the designed sensor using COMSOL shows output voltage of 1 V at breathing frequency of 0 2 Hz
AU  - Panahi, Amir
AU  - Hassanzadeh, Alireza
AU  - Moulavi, Ali
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Design of a low Cost, double triangle, piezoelectric sensor for respiratory monitoring applications
T2  - Sensing and Bio-Sensing Research
TI  - Design of a low Cost, double triangle, piezoelectric sensor for respiratory monitoring applications
UR  - https://doi.org/10.1016/j.sbsr.2020.100378
ID  - 7793054
ER  - 

TY  - JOUR
AB  - Background SARS-CoV-2 (COVID-19) utilizes the angiotensin converting enzyme-2 (ACE-2) receptor to enter human cells. Angiotensin converting enzyme inhibitors (ACEI) and angiotensin II receptor antagonists (ARB) are associated with ACE-2 upregulation. We hypothesized that antecedent use of ACEI/ARB may be associated with mortality in COVID-19. Methods and Results We used the Coracle registry, which contains data of hospitalized COVID-19 patients in 4 regions of Italy, and restricted analyses to those �?50 years of age. The primary outcome was in-hospital mortality. Among these 781 acutely ill patients, 133 (17.0%) used an ARB and 171 (21.9%) used an ACEI. While neither sex nor smoking status differed by user groups, patients on ACEI/ARB tended to be older and more likely to have hypertension, diabetes mellitus, and congestive heart failure. The overall mortality rate was 15.1% (118/781) and increased with age (P(Trend)  0.0001). The crude odds ratios (ORs) for death for ACEI users and ARB users were 0.98, 95% confidence interval (CI): 0.60-1.60, p=0.9333, and 1.13, 95% CI: 0.67-1.91, p=0.6385, respectively. After adjusting for age, hypertension, diabetes mellitus, and congestive heart failure, antecedent ACEI administration was associated with reduced mortality (OR: 0.55, 95% CI: 0.31-0.98, p=0.0436); a similar, but weaker trend was observed for ARB administration (OR: 0.58, 95% CI: 0.32-1.07, p=0.0796). Conclusions In those aged �?0 years hospitalized with COVID-19, antecedent use of ACEI was independently associated with reduced risk of inpatient death. Our findings suggest the protective role of renin-angiotensin-aldosterone system inhibition in patients with high cardiovascular risk affected by COVID-19.
AD  - Cardiovascular Diseases Unit Department of Medical Sciences AOUS Le Scotte Hospital University of Siena Siena Italy.
Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences Sapienza, University of Rome Roma Italy.
Cardiology, Department of Medical Science University of Turin Città della Salute e Della Scienza Le Molinette Hospital Torino Torino Italy.
Section Head Electrophysiology and Cardiac Pacing Azienda Ospedaliera - Polo Universitario - "Luigi Sacco" Milano Italy.
Interventional Cardiology and Cardiac Surgery Unit Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo Alessandria Italy.
Cardiology Division Regina Montis Regalis Hospital Mondovì Cuneo Italy.
Division of Internal Medicine Department of Medical Sciences University of Turin Turin Italy.
Interventional Cardiology Department of Internal Medicine ASSST Nord Milano E Bassini Hospital Cisanello Balsamo Milan Italy.
Cardiovascular Disease Unit Department of Internal Medicine University of Milano Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy.
Infectious Disease Department of Medical Sciences University of Torino AOU Città della salute e della Scienza Torino Italy.
Cardiology Division Ospedale Maggiore of Crema Crema Italy.
Intensive Care University of Pavia Fondation IRCCS Policlinico San Matteo Pavia Italy.
Respiratory Unit and Adult Cystic Fibrosis Center Department of Internal Medicine University of Milano Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico Milano Italy.
Baylor University Medical Center Dallas TX.
Baylor Scott and White Heart and Vascular Hospital Dallas TX.
Baylor Heart and Vascular Institute Dallas TX.
AN  - 33023356
AU  - Palazzuoli, A.
AU  - Mancone, M.
AU  - De Ferrari, G. M.
AU  - Forleo, G.
AU  - Secco, G. G.
AU  - Ruocco, G. M.
AU  - D'Ascenzo, F.
AU  - Monticone, S.
AU  - Paggi, A.
AU  - Vicenzi, M.
AU  - Palazzo, A. G.
AU  - Landolina, M.
AU  - Taravelli, E.
AU  - Tavazzi, G.
AU  - Blasi, F.
AU  - Infusino, F.
AU  - Fedele, F.
AU  - De Rosa, F. G.
AU  - Emmett, M.
AU  - Schussler, J. M.
AU  - Tecson, K. M.
AU  - McCullough, P. A.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1161/jaha.120.017364
DP  - NLM
ET  - 2020/10/08
J2  - Journal of the American Heart Association
KW  - SARS‐CoV�? (COVID�?9)
angiotensin converting enzyme inhibitor
angiotensin converting enzyme�?
hospitalization
mortality
renin‐angiotensin converting enzyme inhibitor
LA  - eng
N1  - 2047-9980
Palazzuoli, Alberto
Mancone, Massimo
De Ferrari, Gaetano M
Forleo, Giovanni
Secco, Gioel G
Ruocco, Gaetano M
D'Ascenzo, Fabrizio
Monticone, Silvia
Paggi, Anita
Vicenzi, Marco
Palazzo, Anna G
Landolina, Maurizio
Taravelli, Erika
Tavazzi, Guido
Blasi, Francesco
Infusino, Fabio
Fedele, Francesco
De Rosa, Francesco G
Emmett, Michael
Schussler, Jeffrey M
Tecson, Kristen M
McCullough, Peter A
Journal Article
England
J Am Heart Assoc. 2020 Oct 7:e017364. doi: 10.1161/JAHA.120.017364.
PY  - 2020
SN  - 2047-9980
SP  - e017364
ST  - Antecedent Administration of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Antagonists and Survival After Hospitalization for SARS-CoV-2 (COVID-19)
T2  - Journal of American Heart Association
TI  - Antecedent Administration of Angiotensin Converting Enzyme Inhibitors or Angiotensin II Receptor Antagonists and Survival After Hospitalization for SARS-CoV-2 (COVID-19)
ID  - 7790915
ER  - 

TY  - JOUR
AB  - Brazil has 896,917 Indigenous individuals distributed among 505 Indigenous lands. There are 274 different Indigenous languages within 305 Indigenous ethnic groups. The Indigenous population is susceptible to pandemics, especially to the current pandemic of COVID-19, which has spread rapidly. In Brazil, after the first COVID-19-confirmed Indigenous case on 05th June 2020, more 420 suspected cases, 1727 confirmed cases being 934 active cases, 715 cases with clinical cure, and 70 cases of death were accounted through the first week of June. The number of cases is underestimated, according to the Special Secretariat for Indigenous Health (SESAI) database, since the deaths are due to respiratory failure, possibly caused by COVID-19, but not confirmed. The first COVID-19-caused death was a 15-year-old Indigenous Yanomami teenage from Roraima State without known previous diseases history and/or comorbidities. In the present study, the importance of social isolation, especially for Indigenous people who are more vulnerable to the COVID-19, was highlighted by the identification of the infection community. An Indigenous of the Kokama ethnicity was infected after coming in contact with a Medical Doctor who was infected with the disease. Later, it was noticed that both, Indigenous and doctor, were responsible for COVID-19's transmission to 43 other Indigenous individuals (30 in Alto Rio Solimões and 13 in Parintis), causing possibly other confirmed deaths. The impact of COVID-19 for Indigenous population might be an unprecedented tragedy, and the government in Brazil must take emergency measures as the social isolation.
AD  - Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University, Avenida São Francisco de Assis, 218. Jardim São José, Bragança Paulista, 12916-000, São Paulo, Brazil.
Laboratory of Human and Medical Genetics, São Francisco University, Avenida São Francisco de Assis, 218. Jardim São José, Bragança Paulista, São Paulo, 12916-900, Brazil.
Laboratory of Cell and Molecular Tumor Biology and Bioactive Compounds, São Francisco University, Avenida São Francisco de Assis, 218. Jardim São José, Bragança Paulista, 12916-000, São Paulo, Brazil. fernandolimamarson@hotmail.com.
Laboratory of Human and Medical Genetics, São Francisco University, Avenida São Francisco de Assis, 218. Jardim São José, Bragança Paulista, São Paulo, 12916-900, Brazil. fernandolimamarson@hotmail.com.
AN  - 33025421
AU  - Palamim, C. V. C.
AU  - Ortega, M. M.
AU  - Marson, F. A. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s40615-020-00885-6
DP  - NLM
ET  - 2020/10/08
J2  - Journal of racial and ethnic health disparities
KW  - Brazil
Covid-19
Coronavirus
Health care
Indigenous
Indigenous population
SARS-CoV-2
Social science
LA  - eng
N1  - 2196-8837
Palamim, Camila Vantini Capasso
Orcid: 0000-0001-6825-1154
Ortega, Manoela Marques
Orcid: 0000-0002-7896-6142
Marson, Fernando Augusto Lima
Orcid: 0000-0003-4955-4234
Journal Article
Switzerland
J Racial Ethn Health Disparities. 2020 Oct 6. doi: 10.1007/s40615-020-00885-6.
PY  - 2020
SN  - 2196-8837
ST  - COVID-19 in the Indigenous Population of Brazil
T2  - Journal of racial and ethnic health disparities
TI  - COVID-19 in the Indigenous Population of Brazil
ID  - 7790707
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The coronavirus disease (COVID-19) pandemic has changed routine clinical practice worldwide with major impacts on the provision of care and treatment for stroke patients. METHODS: This retrospective observational study included all patients admitted to the Royal Stoke University Hospital in Stoke-on-Trent, UK, with a stroke or transient ischaemic attack between March 15th and April 14th, 2020 (COVID). Patient demographics, characteristics of the stroke, treatment details and logistics were compared with patients admitted in the corresponding weeks in the year before (2019). RESULTS: There was a 39.5% (n�?�?01 vs n�?�?67) reduction in admissions in the COVID cohort compared with 2019 with more severe strokes (median National Institutes of Health Stroke Scale (NIHSS) 7 vs 4, p�?�?.02), and fewer strokes with no visible acute pathology (21.8 vs 37.1%, p�?�?.01) on computed tomography. There was no statistically significant difference in the rates of thrombolysis (10.9 vs 13.2%, p�?�?.72) and/or thrombectomy (5.9 vs 4.8%, p�?�?.90) and no statistically significant difference in time from stroke onset to arrival at hospital (734 vs 576 min, p�?�?.34), door-to-needle time for thrombolysis (54 vs 64 min, p�?�?.43) and door-to-thrombectomy time (181 vs 445 min, p�?�?.72). Thirty-day mortality was not significantly higher in the COVID year (10.9 vs 8.9%, p�?�?.77). None of the 7 stroke patients infected with COVID-19 died. CONCLUSIONS: During the COVID-19 pandemic, the number of stroke admissions fell, and stroke severity increased. There was no statistically significant change in the delivery of thrombolysis and mechanical thrombectomy and no increase in mortality.
AD  - Neurosciences, Royal Stoke University Hospital, Stoke-on-Trent, UK. nishita.padmanabhan@uhnm.nhs.uk.
Faculty of Medicine and Health Sciences, Keele University, Staffordshire, UK. nishita.padmanabhan@uhnm.nhs.uk.
Neurosciences, Royal Stoke University Hospital, Stoke-on-Trent, UK.
Statistics and Mathematical Modelling, Department of Molecular Genetics, Erasmus MC, Rotterdam, Netherlands.
Faculty of Medicine and Health Sciences, Keele University, Staffordshire, UK.
AN  - 33021704
AU  - Padmanabhan, N.
AU  - Natarajan, I.
AU  - Gunston, R.
AU  - Raseta, M.
AU  - Roffe, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s10072-020-04775-x
DP  - NLM
ET  - 2020/10/07
J2  - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
KW  - Covid-19
Infarct
Mortality
Stroke
Thrombectomy
Thrombolysis
LA  - eng
N1  - 1590-3478
Padmanabhan, Nishita
Orcid: 0000-0001-6234-7980
Natarajan, Indira
Gunston, Rachel
Raseta, Marko
Roffe, Christine
Journal Article
Italy
Neurol Sci. 2020 Oct 6. doi: 10.1007/s10072-020-04775-x.
PY  - 2020
SN  - 1590-1874
ST  - Impact of COVID-19 on stroke admissions, treatments, and outcomes at a comprehensive stroke centre in the United Kingdom
T2  - Neurological sciences : official journal of Italian Neurological Society and of Italian Society of Clinical Neurophysiology
TI  - Impact of COVID-19 on stroke admissions, treatments, and outcomes at a comprehensive stroke centre in the United Kingdom
ID  - 7791011
ER  - 

TY  - JOUR
AU  - Ozaras, Resat
AU  - Ozdogru, Ibrahim
AU  - Yilmaz, Ahmet Atilla
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Covid-19 Re-Infection: First Report from Turkey
T2  - New Microbes and New Infections
TI  - Covid-19 Re-Infection: First Report from Turkey
UR  - https://doi.org/10.1016/j.nmni.2020.100774
ID  - 7793087
ER  - 

TY  - JOUR
AU  - Oyer, R. A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - ACCC, With an Assist
T2  - Oncology Issues
TI  - ACCC, With an Assist
UR  - https://doi.org/10.1080/10463356.2020.1809866
ID  - 7792969
ER  - 

TY  - JOUR
AU  - Oxenham, John
AU  - Currie, Michael-James
AU  - van der Merwe, Charl
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 Price Gouging Cases in South Africa: Short-term Market Dynamics with Long-term Implications for Excessive Pricing Cases
T2  - Journal of European Competition Law & Practice
TI  - COVID-19 Price Gouging Cases in South Africa: Short-term Market Dynamics with Long-term Implications for Excessive Pricing Cases
UR  - https://doi.org/10.1093/jeclap/lpaa070
ID  - 7792898
ER  - 

TY  - JOUR
AU  - Ovchinnikov, Sergei
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Penitentiary System of Russia during the COVID-19 Pandemic: A Global Challenge and Initial Results
T2  - Victims & Offenders
TI  - The Penitentiary System of Russia during the COVID-19 Pandemic: A Global Challenge and Initial Results
UR  - https://doi.org/10.1080/15564886.2020.1826377
ID  - 7792953
ER  - 

TY  - JOUR
AB  - PURPOSE: To describe a case of inflammatory chorioretinopathy and Adie's syndrome possibly associated with COVID-19. METHODS: Observational case report. RESULTS: A 51-year-old woman developed fever, cough, and headache followed by retro-ocular pain and reading impairment. She tested positive for SARS-COV-2 infection by qualitative real-time reverse-transcriptase-polymerase-chain-reaction. The slit-lamp and funduscopic exam revealed abnormal pupillary response and yellowish creamy deep chorioretinal lesions, which were not present in previous examinations. Instillation of pilocarpine demonstrated denervation supersensitivity, and it was suggestive of bilateral Adie tonic pupil. A comprehensive work-up ruled out other systemic, autoimmune, or infectious diseases. CONCLUSIONS: This case illustrates the possible association between multifocal chorioretinitis and Adie's syndrome, and the SARS-COV-2 infection in humans. Further investigation of virus infectivity specifically within ocular tissues has to be conducted.
AD  - Department of Ophthalmology, Hospital Universitari Doctor Peset , Valencia, Spain.
Department of Rheumatology, Hospital Universitari Doctor Peset , Valencia, Spain.
AN  - 33021422
AU  - Ortiz-Seller, A.
AU  - Mart�Tnez Costa, L.
AU  - Hern֙ndez-Pons, A.
AU  - Valls Pascual, E.
AU  - Solves Alemany, A.
AU  - Albert-Fort, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/09273948.2020.1817497
DP  - NLM
ET  - 2020/10/07
J2  - Ocular immunology and inflammation
KW  - Adie’s pupil
Covid-19
inflammatory chorioretinopathy
multimodal imaging
ophthalmic manifestation
LA  - eng
N1  - 1744-5078
Ortiz-Seller, Amparo
Orcid: 0000-0003-0200-1667
Mart�Tnez Costa, Luc�Ta
Hern֙ndez-Pons, Antonio
Orcid: 0000-0003-4104-7780
Valls Pascual, Elia
Solves Alemany, Alicia
Albert-Fort, Mara
Journal Article
England
Ocul Immunol Inflamm. 2020 Oct 6:1-5. doi: 10.1080/09273948.2020.1817497.
PY  - 2020
SN  - 0927-3948
SP  - 1-5
ST  - Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19)
T2  - Ocular immunology and inflammation
TI  - Ophthalmic and Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 (COVID-19)
ID  - 7791031
ER  - 

TY  - JOUR
AB  - As the second wave of coronavirus disease 2019 (COVID-19) is well under way around the world, the optimal therapeutic approach that addresses virus replication and hyperinflammation leading to tissue injury remains elusive This issue of Clinical Kidney Journal provides further evidence of complement activation involvement in COVID-19 Taking advantage of the unique repeat access to chronic haemodialysis patients, the differential time course of C3 and C5 activation in relation to inflammation and severity of disease have been characterized This further points to complement as a therapeutic target Indeed, clinical trials targeting diverse components of complement are ongoing However, a unique case of COVID-19 in a patient with pre-existent atypical haemolytic syndrome on chronic eculizumab therapy suggests that even early eculizumab may fail to prevent disease progression to a severe stage Finally, preclinical studies in endotoxaemia, another hyperinflammation syndrome characterized by lung and kidney injury, suggest that cilastatin, an inexpensive drug already in clinical use, may provide tissue protection against hyperinflammation in COVID-19
AU  - Ortiz, Alberto
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Complement and protection from tissue injury in COVID-19
T2  - Clinical Kidney Journal
TI  - Complement and protection from tissue injury in COVID-19
UR  - https://doi.org/10.1093/ckj/sfaa196
ID  - 7792922
ER  - 

TY  - JOUR
AB  - As the world recovers from the lockdown imposed by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) pandemic, returning to shared indoor spaces is considered a formidable risk. It is now clear that transmission of SARS-CoV-2 is driven by respiratory microdroplets expelled by infected persons, which can become suspended in the air. Several layering technologies are being explored to mitigate indoor transmission in the hopes of re-opening business, schools and transportation systems. Here we coupled the water adsorptive and photocatalytic capacity of novel Metal Organic Frameworks (MOFs) to demonstrate the capture and inactivation of SARS-CoV-2. Discussion is given on the methods of analysis and the differences between the photocatalytic activity of several MOFs, and the difference between MOF induced photocatalysis and ultra violet photolysis of SARS-CoV-2. Our results are intended to provide support to industry looking for alternative methods secure indoor spaces.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding obtained.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No IRB necessaryAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data generated or analysed during this study are included in this paper. Material characterization information including the crystallinity raw data is available via contributing authors.
AU  - Ornstein, Jason Mathew
AU  - Ozdemir, Ray
AU  - Boehme, Anne
AU  - Serre, Christian
AU  - Nouar, Farid
AU  - Santarpia, Joshua
AU  - Herrera, Vicki L.
AU  - Ackerman, Daniel N.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.01.20204214
DP  - medRxiv
PY  - 2020
SP  - 2020.10.01.20204214
ST  - SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis (preprint)
T2  - medRxiv
TI  - SARS-CoV-2 Inactivation Potential of Metal Organic Framework Induced Photocatalysis (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.01.20204214.abstract
ID  - 7794726
ER  - 

TY  - JOUR
AB  - Objective To determine whether location-linked anaesthesiology calculator mobile application (app) data can serve as a qualitative proxy for global surgical case volumes and therefore monitor the impact of the coronavirus disease 2019 (COVID-19) pandemic. Methods We collected data provided by users of the mobile app "Anesthesiologist" during 1 October 2018-30 June 2020. We analysed these using RStudio and generated 7-day moving-average app use plots. We calculated country-level reductions in app use as a percentage of baseline. We obtained data on COVID-19 case counts from the European Centre for Disease Prevention and Control. We plotted changing app use and COVID-19 case counts for several countries and regions. Findings A total of 100 099 app users within 214 countries and territories provided data. We observed that app use was reduced during holidays, weekends and at night, correlating with expected fluctuations in surgical volume. We observed that the onset of the pandemic prompted substantial reductions in app use. We noted strong cross-correlation between COVID-19 case count and reductions in app use in low- and middle-income countries, but not in high-income countries. Of the 112 countries and territories with non-zero app use during baseline and during the pandemic, we calculated a median reduction in app use to 73.6% of baseline. Conclusion App data provide a proxy for surgical case volumes, and can therefore be used as a real-time monitor of the impact of COVID-19 on surgical capacity. We have created a dashboard for ongoing visualization of these data, allowing policy-makers to direct resources to areas of greatest need. (English) [ABSTRACT FROM AUTHOR]
Objetivo Determinar si los datos de las aplicaciones m�Qviles para calcular la anestesia asociada a la localizaci�Qn pueden servir como un sustituto cualitativo para evaluar la cantidad de intervenciones quirúrgicas a nivel mundial y, por lo tanto, para medir el impacto de la pandemia de la enfermedad del coronavirus 2019 (COVID-19) en esas intervenciones. Métodos Se recopilaron los datos que suministraron los usuarios de la aplicaci�Qn m�Qvil �JAnestesi�Qlogo�� durante el periodo comprendido entre el 1.o de octubre de 2018 y el 30 de junio de 2020. Se analizaron a través de RStudio y se gener�Q un gr֙fico de uso de la aplicaci�Qn con un promedio variable de 7 d�Tas. Se calcularon las reducciones a nivel de pa�Ts en el uso de la aplicaci�Qn como un porcentaje de valor basal. Se obtuvieron datos sobre el recuento de los casos de la COVID-19 del Centro Europeo para la Prevenci�Qn y el Control de las Enfermedades. Se trazaron gr֙ficos sobre el cambio en el uso de las aplicaciones y el recuento de casos de la COVID-19 en varios pa�Tses y regiones. Resultados Un total de 100 099 usuarios de la aplicaci�Qn en 214 pa�Tses y territorios suministraron datos. Se observ�Q que el uso de la aplicaci�Qn se redujo durante los d�Tas festivos, los fines de semana y por las noches, en correlaci�Qn con las fluctuaciones previstas de la cantidad de intervenciones quirúrgicas. Se observ�Q que el inicio de la pandemia gener�Q reducciones sustanciales en el uso de la aplicaci�Qn. Se registr�Q una fuerte correlaci�Qn cruzada entre el recuento de los casos de la COVID-19 y las reducciones en el uso de la aplicaci�Qn en los pa�Tses de ingresos bajos y medios, pero no en los pa�Tses de ingresos altos. De los 112 pa�Tses y territorios que no usaron la aplicaci�Qn durante el momento basal y durante la pandemia, se calcul�Q una reducci�Qn mediana en el uso de la aplicaci�Qn hasta el 73,6 % del valor basal. Conclusi�Qn Los datos de la aplicaci�Qn representan indicadores de la cantidad de intervenciones quirúrgicas y, por lo tanto, se pueden usar para medir en tiempo real el impacto de la COVID-19 en la capacidad quirúrgica. Se ha elaborado un tablero para visualizar estos datos de forma continua, lo que permite a los responsables de formular las pol�Tticas asignar recursos a las ֙reas de mayor necesidad. (Spanish) [ABSTRACT FROM AUTHOR]
Objectif Déterminer si les données provenant d'applications mobiles de calcul dédiées à l'anesthésie et munies d'une fonction de géolocalisation peuvent servir de substitut en vue d'évaluer le nombre d'interventions chirurgicales dans le monde et, par conséquent, de mesurer l'impact de la pandémie de maladie à coronavirus 2019 (COVID-19) sur ces interventions. Méthodes Nous avons récolté les données fournies par les utilisateurs de l'application mobile �JAnesthesiologist�� entre le 1er octobre 2018 et le 30 juin 2020. Nous les avons analysées à l'aide du logiciel RStudio et avons généré des graphiques représentant la moyenne mobile d'utilisation de l'application sur une période de 7 jours. Nous avons calculé les baisses d'utilisation de l'application au niveau national en guise de pourcentage de référence. Nous nous sommes procuré les informations concernant le nombre de cas de COVID-19 aupr؈s du Centre européen de prévention et de contrôle des maladies. Enfin, nous avons représenté sous forme de graphique les variations d'utilisation de l'application ainsi que l'évolution du nombre de cas de COVID-19 dans une série de pays et régions. Résultats Au total, 100 099 utilisateurs originaires de 214 pays et régions nous ont communiqué leurs données. Nous avons observé une diminution dans l'utilisation de l'application durant les vacances, les week-ends et la nuit, ce qui correspond aux fluctuations prévues en mati؈re de volume d'interventions. Nous avons également constaté que l'apparition de la pandémie avait entraîné une baisse considérable de l'utilisation de l'application. Nous avons noté une importante corrélation croisée entre le nombre de cas de COVID-19 et cette baisse d'utilisation dans les pays à faible et moyen revenu, mais pas dans les pays à haut revenu. Sur les 112 pays et régions affichant une utilisation non nulle de l'application pendant la période de référence et pendant la pandémie, nous avons calculé une réduction médiane de 73,6%. Conclusion Les données provenant de l'application fournissent des informations indirectes qui servent à déterminer le nombre d'interventions chirurgicales, et peuvent donc �^tre employées pour suivre en temps réel l'impact de la COVID-19 sur la capacité chirurgicale. Nous avons créé un tableau de bord pour visualiser ces données en continu, ce qui permet aux législateurs d'attribuer des ressources aux secteurs qui en ont le plus besoin. (French) [ABSTRACT FROM AUTHOR]
Це�xь О�\ре��е�xить, мо�Cут �xи ��анные моби�xьно�Cо �\ри�xожения �aа�xь�aу�xятора анестезио�xо�Cии с �\ри�{яз�aой �a место�\о�xожению с�xужить �aачест�{енным �\о�aазате�xем �C�xоба�xьных объемо�{ хирур�Cичес�aих о�\ераций и, с�xе��о�{ате�xьно, отс�xежи�{ать �{�xияние �\ан��емии �aорона�{ирусно�Cо забо�xе�{ания 2019 �C. (COVID-19). Мето��ы А�{торы собра�xи ��анные, �\ре��оста�{�xенные �\о�xьзо�{ате�xями моби�xьно�Cо �\ри�xожения �JАнестезио�xо�C�� �{ �\ерио�� с 1 о�aтября 2018 �C. �\о 30 июня 2020 �C. �fти ��анные бы�xи �\роана�xизиро�{аны с �\омощью �\ро�Cраммы RStudio, и �\о ним бы�xи �\остроены �Cрафи�aи ис�\о�xьзо�{ания �\ри�xожения ���xя с�aо�xьзящих сре��них �\о�aазаний за 7 ��ней. Со�aращение ис�\о�xьзо�{ания �\ри�xожения на уро�{не страны бы�xо рассчитано �{ �{и��е �\роценто�{ от исхо��но�Cо уро�{ня. Данные о �aо�xичест�{е с�xучае�{ COVID-19 а�{торы �\о�xучи�xи из Е�{ро�\ейс�aо�Cо центра �\о �aонтро�xю и �\рофи�xа�aти�aе забо�xе�{аний. А�{торы соста�{и�xи �Cрафи�a изменения ис�\о�xьзо�{ания �\ри�xожения �{ за�{исимости от �aо�xичест�{а с�xучае�{ COVID-19 ���xя нес�aо�xь�aих стран и ре�Cионо�{. Резу�xьтаты Данные бы�xи �\о�xучены от 100 099 �\о�xьзо�{ате�xей �\ри�xожения из 214 стран и территорий. Бы�xо отмечено, что ис�\о�xьзо�{ание �\ри�xожения со�aраща�xось �{ �\раз��ничные ��ни, �{ыхо��ные ��ни и ночью, что соотносится с ожи��аемыми �aо�xебаниями объема хирур�Cичес�aих о�\ераций. Та�aже бы�xо отмечено, что нача�xо �\ан��емии �\ри�{е�xо �a значите�xьному со�aращению ис�\о�xьзо�{ания �\ри�xожения. А�{торы наб�xю��а�xи си�xьную �{заимную �aорре�xяцию меж��у �aо�xичест�{ом с�xучае�{ COVID-19 и со�aращением ис�\о�xьзо�{ания �\ри�xожения �{ странах с низ�aим и сре��ним уро�{нем ��охо��а, но не �{ странах с �{ысо�aим уро�{нем ��охо��а. По ��анным ���xя 112 стран и территорий с нену�xе�{ым ис�\о�xьзо�{анием �\ри�xожения �{о �{ремя исхо��но�Cо уро�{ня и �{о �{ремя �\ан��емии ме��ианное со�aращение ис�\о�xьзо�{ания �\ри�xожения соста�{и�xо ��о 73,6% от исхо��но�Cо уро�{ня. Вы�{о�� Данные �\ри�xожения с�xужат �aос�{енной оцен�aой �aо�xичест�{а �\ро�{о��имых хирур�Cичес�aих о�\ераций и, с�xе��о�{ате�xьно, мо�Cут ис�\о�xьзо�{аться �{ �aачест�{е сре��ст�{а мониторин�Cа �{оз��ейст�{ия COVID-19 на хирур�Cичес�aий �\отенциа�x �{ режиме реа�xьно�Cо �{ремени. А�{торы соз��а�xи �\ане�xь ин��и�aаторо�{ ���xя не�\реры�{ной �{изуа�xизации этих ��анных, �aоторая �\оз�{о�xяет �xицам, формирующим �\о�xити�aу, на�\ра�{�xять ресурсы �{ об�xасти, �C��е �\отребности я�{�xяются наибо�xее острыми. (Russian) [ABSTRACT FROM AUTHOR]
目的 ���定定位麻醉学计���器�U�d��应用�E�序�Q�以下简 �U�应用）数据是否可以作�ؓ全球外科手术量的定�?替代指标�Q�从而监��?2019 �q�全球流行病冠状病毒 (COVID-19) 产生的媄响�?�Ҏ�� 我们攉����?2018 �q?10 �?1 日至 2020 �q?6 �?30 日期��_���U�d��应用�E�序麻醉�?(Anesthesiologist) 用户 的��用数据。我们利�?Rstudio 分析�q�些数据�Q��ƈ�l?制出 7 天内使用应用的移动��^均曲�U�图。我们计��?出国家或地区应用使用人数削减数量占基准值的癑ֈ� 比。我们从�Ƨ洲疄���预防控制中心了解到新型冠状病 毒肺炎病例数。我们绘制了一些国家和地区应用使用 人数和新型冠状病毒肺炎病例数量变化图�?�l�果 214 个国家和地区共有 100,099 名应用用��h���?了数据。我们发玎ͼ�应用使用人数在节假日、周末和 晚间有所减少�Q�这与外�U�手术量的预期�L动有养I���?们还观察刎ͼ�全球性流行病爆发��D��应用使用人数�?�q�度下降。我们也注意刎ͼ�在中低收入国�Ӟ��新型�?状病毒肺炎病例与应用使用人数减少存在很强的互�?��x��，而在高收入国家则不存在。基准线和全球性流 行病爆发期间�Q�应用��用�h数非零的 112 个国家和�?��Z���Q�我们得出其中位��C��降到基准�U�的 73.6%�?�l�论 应用数据可以作�ؓ外科手术台次的替代指标，�?此可用来实时监测新型冠状病毒肺炎对外�U�手术量�?影响。我们设计了一个��A表盘�Q�以便不间断地提供可 视化数据�Q�从而决�{�者可���资源集中于最需要的地区�?(Chinese) [ABSTRACT FROM AUTHOR]
Copyright of Bulletin of the World Health Organization is the property of World Health Organization and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146242038
AU  - O'Reilly-Shah, Vikas N.
AU  - Van Cleve, Wil
AU  - Long, Dustin R.
AU  - Moll, Vanessa
AU  - Evans, Faye M.
AU  - Sunshine, Jacob E.
AU  - Kassebaum, Nicholas J.
AU  - Harrison, Ewen M.
AU  - Jabaley, Craig S.
C1  - 10/7/2020
DB  - a9h
DO  - 10.2471/BLT.20.264044
DP  - EBSCOhost
IS  - 10
M3  - Article
N1  - O'Reilly-Shah, Vikas N. 1; Email Address: voreill@uw.edu Van Cleve, Wil 2 Long, Dustin R. 1 Moll, Vanessa 3 Evans, Faye M. 4 Sunshine, Jacob E. 1 Kassebaum, Nicholas J. 2 Harrison, Ewen M. 5 Jabaley, Craig S. 6; Affiliation: 1: Department of Anesthesiology & Pain Medicine, University of Washington School of Medicine, RR450, 1959 NE Pacific St, Seattle, Washington 98195, United States of America (USA) 2: Institute for Health Metrics and Evaluation, University of Washington, Seattle, USA 3: Institute of Anesthesiology, University Hospital Zurich, Zurich, Switzerland 4: Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston, USA 5: Usher Institute, University of Edinburgh, Edinburgh, Scotland, United Kingdom 6: Department of Anesthesiology, Emory University School of Medicine, Atlanta, USA; Source Info: Oct2020, Vol. 98 Issue 10, p671; Number of Pages: 12p; Document Type: Article
PY  - 2020
SN  - 00429686
SP  - 671-682
ST  - Impact of COVID-19 response on global surgical volumes: an ongoing observational study
T2  - Bulletin of the World Health Organization
TI  - Impact of COVID-19 response on global surgical volumes: an ongoing observational study
TT  - دصرلا لىع ةمئاق ةلصاوتم ةسارد :ةيلماعلا ةحارلجا ماجحأ لىع 19 ديفوكل ة��اجتسلاا يرثأت.

UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146242038&site=ehost-live
VL  - 98
ID  - 7789308
ER  - 

TY  - JOUR
AD  - Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, Portland, OR, USA.
School of Medicine Department of Neurology, Oregon Health and Sciences University, Portland, OR, USA.
Oregon Institute of Occupational Health Sciences, Oregon Health and Sciences University, Portland, OR, USA. bowlesn@ohsu.edu.
AN  - 33021713
AU  - Ordaz-Johnson, O. H.
AU  - Croff, R. L.
AU  - Robinson, L. D.
AU  - Shea, S. A.
AU  - Bowles, N. P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11606-020-06259-2
DP  - NLM
ET  - 2020/10/07
J2  - Journal of general internal medicine
LA  - eng
N1  - 1525-1497
Ordaz-Johnson, Omar H
Croff, Raina L
Robinson, LaTroy D
Shea, Steven A
Bowles, Nicole P
Orcid: 0000-0003-3729-7082
UL1TR000128/Oregon Clinical and Translational Research Institute/
KL2TR002370/Oregon Clinical and Translational Research Institute/
R01 HL142064/HL/NHLBI NIH HHS/United States
Letter
United States
J Gen Intern Med. 2020 Oct 6. doi: 10.1007/s11606-020-06259-2.
PY  - 2020
SN  - 0884-8734
ST  - More Than a Statistic: a Qualitative Study of COVID-19 Treatment and Prevention Optimization for Black Americans
T2  - Journal of general internal medicine
TI  - More Than a Statistic: a Qualitative Study of COVID-19 Treatment and Prevention Optimization for Black Americans
ID  - 7791010
ER  - 

TY  - JOUR
AB  - BACKGROUND: In March 2020, the UK Intercollegiate General Surgery Guidance on COVID-19 recommended that patients undergoing emergency abdominal CT should have a complementary CT chest for COVID-19 screening. PURPOSE: To establish if complementary CT chest was performed as recommended, and if CT chest influenced surgical intervention decision. To assess detection rate of COVID-19 on CT and its correlation with RT-PCR swab results. To determine if COVID-19 changes is reliably detected within the lung bases which are usually imaged in standard abdominal CT. METHODS: Patients with acute abdominal symptoms presenting to a single institution between 1st and 30th April 2020 who had abdominal CT and complementary CT chest were retrospectively extracted from Computerised Radiology Information System. CT COVID-19 changes were categorised according to British Society of Thoracic Radiology reporting guidance. Patient demographics (age and gender), RT-PCR swab results and management pathway (conservative or intervention) were recorded from electronic patient records. Statistical analyses were performed to evaluate any significant association between variables. p values �?.05 were regarded as statistically significant. RESULTS: Compliancy rate in performing complementary CT chest was 92.5% (148/160). Thirty-five patients (35/148,23.6%) underwent intervention during admission. There was no significant association (p�?�?.9085) between acquisition of CT chest and management pathway (conservative vs intervention). CT chest had 57% sensitivity (CI 18.41% to 90.1%) and 100% specificity (CI 92% to 100%) in COVID-19 diagnosis. Three of ten patients who had classic COVID-19 changes on CT chest did not have corresponding changes in lung bases. CONCLUSION: Compliance with performing complementary CT chest in acute abdomen patients for COVID-19 screening was high and it did not influence subsequent surgical or interventional management.
AN  - PMC7536516
AU  - Ooi, M. W. X.
AU  - Liong, S. Y.
AU  - Baguley, N.
AU  - Sharman, A.
AU  - Tuck, J.
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.clinimag.2020.09.009
DP  - NLM
J2  - Clin Imaging
KW  - Coronavirus
COVID-19
Screening
Acute abdomen
Management
COVID-19, SARS-CoV-2 disease 2019
CRIS, Computerised Radiology Information System
BSTI, British Society of Thoracic Radiology
RCR, Royal College of Radiologists
RT-PCR, reverse transcriptase polymerase chain reaction
EPR, electronic patient record
LA  - eng
N1  - PMC7536516[pmcid]
S0899-7071(20)30353-3[PII]
PY  - 2020
SN  - 0899-7071
1873-4499
ST  - Role of complementary Ct chest in patients presenting with acute abdominal symptoms during covid-19 pandemic: a UK experience
T2  - Clinical Imaging
TI  - Role of complementary Ct chest in patients presenting with acute abdominal symptoms during covid-19 pandemic: a UK experience
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536516/
ID  - 7790665
ER  - 

TY  - JOUR
AB  - Among Italy, Spain, and Japan, the age distributions of COVID-19 mortality show only small variation even though the number of deaths per country shows large variation. To understand the determinant for this situation, we constructed a mathematical model describing the transmission dynamics and natural history of COVID-19 and analyzed the dataset of mortality in Italy, Spain, and Japan. We estimated the parameter which describes the age-dependency of susceptibility by fitting the model to reported data, including the effect of change in contact patterns during the epidemics of COVID-19, and the fraction of symptomatic infections. Our study revealed that if the mortality rate or the fraction of symptomatic infections among all COVID-19 cases does not depend on age, then unrealistically different age-dependencies of susceptibilities against COVID-19 infections between Italy, Japan, and Spain are required to explain the similar age distribution of mortality but different basic reproduction numbers (R(0)). Variation of susceptibility by age itself cannot explain the robust age distribution in mortality by COVID-19 infections in those three countries, however it does suggest that the age-dependencies of (i) the mortality rate and (ii) the fraction of symptomatic infections among all COVID-19 cases determine the age distribution of mortality by COVID-19.
AD  - Research Center for Zoonosis Control, Hokkaido University, Kita-20 Nishi-10, Kita-Ku, Sapporo, Hokkaido, 001-0020, Japan. omori@czc.hokudai.ac.jp.
Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Department of Physics and Mathematics, Aoyama Gakuin University, Tokyo, Japan.
AN  - 33024235
AU  - Omori, R.
AU  - Matsuyama, R.
AU  - Nakata, Y.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73777-8
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Omori, Ryosuke
Matsuyama, Ryota
Nakata, Yukihiko
19K20393/Japan Society for the Promotion of Science/
16K20976/Japan Society for the Promotion of Science/
JPMJCR1413/Core Research for Evolutional Science and Technology/
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16642. doi: 10.1038/s41598-020-73777-8.
PY  - 2020
SN  - 2045-2322
SP  - 16642
ST  - The age distribution of mortality from novel coronavirus disease (COVID-19) suggests no large difference of susceptibility by age
T2  - Scientific reports
TI  - The age distribution of mortality from novel coronavirus disease (COVID-19) suggests no large difference of susceptibility by age
VL  - 10
ID  - 7790831
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has generated an enormous amount of data, providing a unique opportunity for modeling and analysis. In this paper, we present a data-informed approach for building stochastic compartmental models that is grounded in the Markovian processes underlying these models. Our initial data analyses reveal that the SIRD model -- susceptiple (S), infected (I), recovered (R), and death (D) -- is not consistent with the data. In particular, the transition times expressed in the dataset do not obey exponential distributions, implying that there exist unmodeled (hidden) states. We make use of the available epidemiological data to inform the location of these hidden states, allowing us to develop an augmented compartmental model which includes states for hospitalization (H) and end of infectious viral shedding (V). Using the proposed model, we characterize delay distributions analytically and match model parameters to empirical quantities in the data to obtain a good model fit. Insights from an epidemiological perspective are presented, as well as their implications for mitigation and control strategies.Competing Interest StatementThe authors have declared no competing interest.Funding StatementResearch supported in part by the C3.ai Digital Transformation Institute sponsored by C3.ai Inc. and the Microsoft Corporation, in part by the Jump ARCHES endowment through the Health Care Engineering Systems Center of the University of Illinois at Urbana-Champaign, and in part by the National Science Foundation grant NSF-ECCS 20-32321.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Only the publicly available data were used in this study. Therefore, an IRB review was not required.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data referred in this study are collected from publicly available resources. Centers for Disease Control and Prevention, COVID-19 Case Surveillance Public Use Data, https://data.cdc.gov/Case-Surveillance/COVID-19-Case-Surveillance-Public-Use-Data/vbim-akqf/data, 2020. M. Kraemer, Epidemiological data from the nCoV-2019 outbreak: Early descriptions from publicly available data, https://virological.org/t/epidemiological-data-from-the-ncov-2019-outbreak-early-descriptions-from-publicly-available-data/337, 2020. midas network, COVID-19, https://github.com/midas-network/COVID-19/blob/master/data/cases/global/line_listings_imperial_college/international_cases_2020_08_02.csv, 2020. Y. Xu, COVID19 inpatient cases data, https://doi.org/10.6084/m9.figshare.12195735.v3, 2020. ThisIsIsaac,Data-Science-for-COVID-19, https://github.com/ThisIsIsaac/Data-Science-for-COVID-19/blob/master/Covid19_Dataset/patients.csv, 2020. mrc ide,COVID19_CFR_submission,https://github.com/ mrc-ide/COVID19_CFR_submission/blob/master/data/deaths_integrated_with_linelist_17feb.csv, 2020. Public line list and summaries of the COVID-19 outbreak in South Korea, https://github.com/parksw3/COVID19-Korea/blob/master/COVID19-Korea-2020-04-06.xlsx, 2020. Novel Coronavirus 2019 time series data on cases, https://github.com/datasets/covid-19, 2020. I. Dorigatti, L. Okell, A. Cori, N. Ima , M. Baguelin, S. Bhatia, A. Boonyasiri, Z. Cucunuba, G. Cuomo-Dannenburg, R. FitzJohn et al., Report 4: Severity of 2019-novel coronavirus (nCoV), Imperial College London, London, 2020.
AU  - Olmez, Sukru Yagiz
AU  - Mori, Jameson
AU  - Miehling, Erik
AU  - Basar, Tamer
AU  - Smith, Rebecca Lee
AU  - West, Matthew
AU  - Mehta, Prashant
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206250
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206250
ST  - A Data-Informed Approach for Analysis, Validation, and Identification of COVID-19 Models (preprint)
T2  - medRxiv
TI  - A Data-Informed Approach for Analysis, Validation, and Identification of COVID-19 Models (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206250.1.abstract
ID  - 7794738
ER  - 

TY  - JOUR
AB  - AIMS: Hospitalised patients with COVID-19 have a variable incidence of acute kidney injury (AKI) according to studies from different nationalities. The present systematic review and meta-analysis describes the incidence of AKI, need for renal replacement therapy (RRT) and mortality among patients with COVID-19-associated AKI. METHODS: We systematically searched electronic database PubMed, SCOPUS and Web of Science to identify English articles published until 25 May 2020. In case of significant heterogeneity, the meta-analyses were conducted assuming a random-effects model. RESULTS: From 746 screened publications, we selected 21 observational studies with 15 536 patients with COVID-19 for random-effects model meta-analyses. The overall incidence of AKI was 12.3% (95% CI 7.3% to 20.0%) and 77% of patients with AKI were critically ill (95% CI 58.9% to 89.0%). The mortality among patients with AKI was 67% (95% CI 39.8% to 86.2%) and the risk of death was 13 times higher compared with patients without AKI (OR=13.3; 95% CI 6.1 to 29.2). Patients with COVID-19-associated AKI needed for RRT in 23.4% of cases (95% CI 12.6% to 39.4%) and those cases had high mortality (89%-100%). CONCLUSION: The present study evidenced an incidence of COVID-19-associated AKI higher than previous meta-analysis. The majority of patients affected by AKI were critically ill and mortality rate among AKI cases was high. Thus, it is extremely important for health systems to be aware about the impact of AKI on patients' outcomes in order to establish proper screening, prevention of additional damage to the kidneys and adequate renal support when needed.
AD  - Keizo Azami Immunopathology Laboratory, Universidade Federal de Pernambuco, Recife, Brazil camilabarbosalyra@hotmail.com.
Department of Nephrology, Universidade Federal de Pernambuco, Recife, Brazil.
Keizo Azami Immunopathology Laboratory, Universidade Federal de Pernambuco, Recife, Brazil.
Department of Oceanography, Universidade Federal de Pernambuco, Recife, Brazil.
Department of Genetics, Universidade Federal de Pernambuco, Recife, Brazil.
AN  - 33023941
AU  - Oliveira, C. B.
AU  - Lima, C. A. D.
AU  - Vajgel, G.
AU  - Campos Coelho, A. V.
AU  - Sandrin-Garcia, P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/jclinpath-2020-207023
DP  - NLM
ET  - 2020/10/08
J2  - Journal of clinical pathology
KW  - death
epidemiology
kidney
viruses
LA  - eng
N1  - 1472-4146
Oliveira, Camila Barbosa
Orcid: 0000-0003-2080-923x
Lima, Camilla Albertina Dantas
Vajgel, Gisele
Campos Coelho, Antonio Victor
Orcid: 0000-0003-2143-9701
Sandrin-Garcia, Paula
Journal Article
England
J Clin Pathol. 2020 Oct 6:jclinpath-2020-207023. doi: 10.1136/jclinpath-2020-207023.
PY  - 2020
SN  - 0021-9746
ST  - High burden of acute kidney injury in COVID-19 pandemic: systematic review and meta-analysis
T2  - Journal of clinical pathology
TI  - High burden of acute kidney injury in COVID-19 pandemic: systematic review and meta-analysis
ID  - 7790860
ER  - 

TY  - JOUR
AB  - Stimulation and generation of T and B cell mediated long-term immune response is essential for the curbing of a deadly virus such as SAR-CoV-2 Immunoinformatics approach in vaccine design takes advantage of antigenic and non-allergenic epitopes present on the spike glycoprotein of SARS-CoV-2 to elicit immune responses T cells and B cells epitopes were predicted, and the selected residues were subjected to allergenicity, antigenicity and toxicity screening which were linked by appropriate linkers to form a multi-epitope subunit vaccine The physiochemical properties of the vaccine construct was analyzed and the molecular weight, molecular formula, theoretical isoelectric point value, half-life, solubility score, instability index, aliphatic index and GRAVY were predicted The vaccine structure was constructed, refined, validated, and disulfide engineered to get the best model Molecular binding simulation and molecular dynamics simulation were carried out to predict the stability and binding affinity of the vaccine construct with TLRs Codon acclimatization and in silico cloning were performed to confirm the vaccine expression and potency Results obtained indicated that this novel vaccine candidate is non-toxic, capable of initiating the immunogenic response and will not induce an allergic reaction The highest binding energy was observed in TLR 4 (-1398 1) and the least is TLR 2 (-1479 6) The steady rise in Th (helper) cell population with memory development was noticed and IFN-g was provoked after simulation At this point, the vaccine candidate awaits animal trial to validate its efficacy and safety for use in the prevention of the novel COVID-19 infections
AU  - Oladipo, Elijah Kolawole
AU  - Ajayi, Ayodeji Folorunsho
AU  - Ariyo, Olumuyiwa Elijah
AU  - Onile, Samson Olugbenga
AU  - Jimah, Esther Moradeyo
AU  - Ezediuno, Odinakaose Louis
AU  - Adebayo, Oluwadunsin Iyanuoluwa
AU  - Adebayo, Emmanuel Tayo
AU  - Odeyemi, Aduragbemi Noah
AU  - Oyeleke, Marvellous Oluwaseun
AU  - Oyewole, Moyosoluwa Precious
AU  - Oguntomi, Ayomide Samuel
AU  - Akindiya, Olawumi Elizabeth
AU  - Olamoyegun, Bunmi Olayemi
AU  - Aremu, Victoria Oyetayo
AU  - Arowosaye, Abiola O.
AU  - Aboderin, Dorcas Olubunmi
AU  - Bello, B. Habibat
AU  - Senbadejo, Y. Tosin
AU  - Awoyelu, Elukunbi Hilda
AU  - Oladipo, Adio Abayomi
AU  - Oladipo, Bukola Bisola
AU  - Ajayi, Lydia Oluwatoyin
AU  - Majolagbe, Olusola Nathaniel
AU  - Oyawoye, Olubukola Monisola
AU  - Oloke, Julius Kola
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - EXPLORING SURFACE GLYCOPROTEIN TO DESIGN MULTI-EPITOPE VACCINE AGAINST COVID-19
T2  - Informatics in Medicine Unlocked
TI  - EXPLORING SURFACE GLYCOPROTEIN TO DESIGN MULTI-EPITOPE VACCINE AGAINST COVID-19
UR  - https://doi.org/10.1016/j.imu.2020.100438
ID  - 7793155
ER  - 

TY  - GEN
AN  - NCT04577534
AU  - Oksi, Jarmo
AU  - Hospital, Turku University
C1  - 10/7/2020
DA  - August 14
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19
N1  - No Results Available
Drug: iv Tocillizumab (TCZ)
Clinical status at day 28|Time to clinical improvement|Time to decline of at least 2 categories|Incidence of mechanical and/or non-invasive ventilation|Number of ventilator-free days to day 28|Organ failure free days to day 28|Incidence of ICU stay|Duration of ICU stay|Time to clinical failure|SAPS II|CCI|APACHE II|SOFA 6|Mortality rate|Time to hospital discharge or "ready for discharge"|Duration of supplemental oxygen
All
Phase 3
90
Other
Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: None (Open Label)|Primary Purpose: Treatment
EudraCT 2020-002039-31|2020-002039-31|T124/2020|KLnro 36/2020|dnro 68/06.00.01/2020
December 31, 2021
PB  - https://ClinicalTrials.gov/show/NCT04577534
PY  - 2020
ST  - covidstorm
T2  - ClinicalTrials
TI  - COVID-19: Salvage TOcilizumab as a Rescue Measure
UR  - https://ClinicalTrials.gov/show/NCT04577534
ID  - 7794693
ER  - 

TY  - JOUR
AU  - Oketa, Atsushi
AU  - Okayasu, Natsuki
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Survey report of the influences of the new coronavirus in the morning market of Katsuura City
T2  - International Journal of Human Culture Studies
TI  - Survey report of the influences of the new coronavirus in the morning market of Katsuura City
UR  - https://doi.org/10.9748/hcs.2020.630
ID  - 7792727
ER  - 

TY  - JOUR
AB  - Introduction and objectives The Interventional Cardiology Association of the Spanish Society of Cardiology (ACI-SEC) presents its annual report on the activity for 2019 Methods All Spanish centers with a catheterization laboratory were invited to participate Data were introduced online and analyzed by an external company together with the Steering Committee of the ACI-SEC Results A total of 119 centers participated (83 public, 36 private) In all, there were 165124 diagnostic studies (4 7% more than in 2018) The use of pressure wire and intravascular ultrasound increased by 20% and that of optical coherence tomography by 8 4% The number of percutaneous coronary interventions (PCI) rose by 4 5% (75 819 procedures) Of these, 22529 were performed in the acute myocardial infarction setting, with 91 8% being primary PCI (6 3% increase) The mean number of primary PCIs per million inhabitants increased to 439 Among PCIs, access was radial in 88 3% There were 4281 transcatheter aortic valve implantations (21 0% increase), with an average of 90 9 per million inhabitants Mitral valve repair also rose by 17 4% (n=385), left atrial appendage closure by 43 0% (n=921) and patent foramen ovale closure by 38 1% (n=710) Conclusions In 2019, the use of intracoronary diagnostic techniques increased, as did that of diagnostic and therapeutic coronary procedures, mainly in primary PCI Of particular note was the marked increase in the number of transcatheter aortic valve implantations, as well as in the number of mitral valve repairs and left atrial appendage and patent foramen ovale closure procedures Resumen Introducci�Qn y objetivos La Asociaci�Qn de Cardiolog�Ta Intervencionista de la Sociedad Española de Cardiolog�Ta (ACI-SEC) presenta su informe anual de actividad de 2019 Métodos Se invit�Q a participar a todos los centros españoles con laboratorio de hemodin֙mica La recogida de datos se realiz�Q telem֙ticamente y una empresa externa, junto con los miembros de la ACI-SEC, llev�Q a cabo su an֙lisis Resultados Participaron 119 centros (83 públicos y 36 privados) Se realizaron 165 124 estudios diagn�Qsticos (el 4,7% m֙s que en 2018) La gu�Ta de presi�Qn y la ecograf�Ta intracoronaria crecieron un 20% y la tomograf�Ta de coherencia �Qptica, un 8,4% El intervencionismo coronario aument�Q un 4,5%, con 75 819 procedimientos De ellos, 22 529 en el infarto agudo de miocardio, con el 91,8% de angioplastias primarias (el 6,3% m֙s que en 2018) La media de angioplastias primarias por mill�Qn de habitantes creci�Q a 439 El acceso fue radial en el 88,3% de los procedimientos intervencionistas Se practicaron 4 281 implantes percut֙neos de v֙lvula a�Qrtica (el 21,0% m֙s que en 2018), con una media de 90,9 por mill�Qn de habitantes La reparaci�Qn percut֙nea mitral también creci�Q un 17,4% (385 procedimientos);el cierre de orejuela, un 43,0% (n=921) y el foramen oval permeable, un 38,1% (n=710) Conclusiones En 2019 se produjo un incremento del uso de técnicas de diagn�Qstico intracoronarias y prodecimientos diagn�Qsticos y terapéuticos coronarios, fundamentalmente en la angioplastia primaria En intervencionismo estructural, destaca el fuerte ascenso del número de implantes percut֙neos de v֙lvula a�Qrtica, as�T como de procedimientos de reparaci�Qn mitral, cierre de orejuela y foramen oval permeable
AU  - Ojeda, Soledad
AU  - Romaguera, Rafael
AU  - Cruz-Gonz֙lez, Ignacio
AU  - Moreno, Raúl
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Spanish Cardiac Catheterization and Coronary Intervention Registry. 29th Official Report of the Interventional Cardiology Association of the Spanish Society of Cardiology (1990-2019)
T2  - Revista Española de Cardiolog�Ta (English Edition)
TI  - Spanish Cardiac Catheterization and Coronary Intervention Registry. 29th Official Report of the Interventional Cardiology Association of the Spanish Society of Cardiology (1990-2019)
UR  - https://doi.org/10.1016/j.rec.2020.09.005
ID  - 7793068
ER  - 

TY  - JOUR
AB  - We demonstrate that universal scaling behavior is observed in the current corona virus (SARS-CoV-2) spread, the COVID-19 pandemic, in various countries We analyze the numbers of infected people who tested positive (cases) in selected eleven countries (Japan, USA, Russia, Brazil, China, Italy, Indonesia, Spain, South Korea, UK, and Sweden) By using the double exponential function called the Gompertz function, fG(x) = exp(–e–x), the number of cases is well described as N(t) = N0fG(��(t �?t0)), where N0, �� and t0 are the final number of cases, the damping rate of the infection probability and the peak time of the daily number of new cases, dN(t)/dt, respectively The scaled data of cases in most of the analyzed countries are found to collapse onto a common scaling function fG(x) with x = ��(t �?t0) being the scaling variable in the range of fG(x) �u 0 05 The recently proposed indicator so-called the K value, the increasing rate of cases in one week, is also found to show universal behavior The mechanism for the Gompertz function to appear is discussed from the time dependence of the produced pion numbers in nucleus-nucleus collisions, which is also found to be described by the Gompertz function
AU  - Ohnishi, Akira
AU  - Namekawa, Yusuke
AU  - Fukui, Tokuro
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Universality in COVID-19 spread in view of the Gompertz function
T2  - Progress of Theoretical and Experimental Physics
TI  - Universality in COVID-19 spread in view of the Gompertz function
UR  - https://doi.org/10.1093/ptep/ptaa148
ID  - 7792895
ER  - 

TY  - JOUR
AB  - This study describes the development of a novel assay for SARS-CoV-2 identification using LC-MS/MS analysis. A multi-step procedure for the rational down-selection of a set of markers has leaded to the discovery of six SARS-CoV-2 specific and sensitive markers, enabling the reliable identification of the virus. A rapid and simple assay was developed, successfully applied to clinical nasopharyngeal samples. The assay may potentially serve as a complementary approach for SARS-CoV-2 identification.
AU  - Ofir, Schuster
AU  - Anat, Zvi
AU  - Osnat, Rosen
AU  - Hagit, Achdout
AU  - Amir, Ben-Shmuel
AU  - Ohad, Shifman
AU  - Shmuel, Yitzhaki
AU  - Orly, Laskar
AU  - Liron, Feldberg
C1  - 10/7/2020
DB  - chemRxiv
DO  - 10.26434/chemrxiv.13055873.v2
DP  - chemRxiv
KW  - SARS-CoV-2
identification method
LC-MS/MS
Spike
Nucleoprotein
marker
PY  - 2020
ST  - Specific and Rapid SARS-CoV-2 Identification Based on LC-MS/MS Analysis (preprint)
T2  - chemRxiv
TI  - Specific and Rapid SARS-CoV-2 Identification Based on LC-MS/MS Analysis (preprint)
UR  - https://chemrxiv.org/articles/preprint/Specific_and_Rapid_SARS-CoV-2_Identification_Based_on_LC-MS_MS_Analysis/13055873
ID  - 7794785
ER  - 

TY  - JOUR
AU  - Oeda, Shinichi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Impact of the Corona (COVID-19) Related Crisis on the Future of School Education
T2  - Journal of JSEE
TI  - The Impact of the Corona (COVID-19) Related Crisis on the Future of School Education
UR  - https://doi.org/10.4307/jsee.68.5_88
ID  - 7792749
ER  - 

TY  - JOUR
AU  - Oakes, G.
AU  - Jeffrey, J.
AU  - Pardhan, A.
AU  - Tang, J.
AU  - Jhaveri, R.
AU  - Leung, J.
AU  - Rahal, M.
AU  - Natarajan, M.
AU  - Woodward, G.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - USING CORHEALTH CARDIAC REGISTRY DATA TO MONITOR AND COMPARE CARDIAC ACTIVITY ACROSS ONTARIO IN REAL TIME DURING THE COVID-19 PANDEMIC
T2  - Canadian Journal of Cardiology
TI  - USING CORHEALTH CARDIAC REGISTRY DATA TO MONITOR AND COMPARE CARDIAC ACTIVITY ACROSS ONTARIO IN REAL TIME DURING THE COVID-19 PANDEMIC
UR  - https://doi.org/10.1016/j.cjca.2020.07.173
ID  - 7793208
ER  - 

TY  - JOUR
AU  - O’Rourke, Marian
AU  - Maguire, Catherine
AU  - Tanner, Liz
AU  - Mullineux, Judith Catherine
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Testing partnership and preparedness in Northern Ireland during COVID-19
T2  - Social Work Education
TI  - Testing partnership and preparedness in Northern Ireland during COVID-19
UR  - https://doi.org/10.1080/02615479.2020.1825664
ID  - 7792983
ER  - 

TY  - JOUR
AB  - Multiplexing has been highlighted to save on costs, increase sample throughput, and maximize on the number of targets that can be sensitively detected within a small sample. With the ongoing SARS-CoV-2 pandemic, different articles have been published highlighting the superiority of droplet digital PCR (ddPCR) over the gold reverse transcription PCR (RT-PCR) in SARS-CoV-2 detection. However, few studies have been reported on developing multiplex ddPCR assays for SARS-CoV-2 detection and their performance. In this study, we developed simplex (1 target), duplex (2 targets), triplex probe mix (3 targets), and fourplex (4 targets) assays based on a two color ddPCR system for SARS-CoV-2 detection. Results showed that the fourplex assay had the similar limits of detection and accuracy to the lower multiplex assays. Analyzing 94 clinical isolates demonstrated that the ddPCR triplex probe mix assay had better sensitivity than the RT-qPCR assay. Additionally, the ddPCR multiplex assay showed that remdesivir could inhibit the growth of SARS-CoV-2 in vitro while another testing drug couldn&#039;t. Conclusively, our research shows that developing multiplex ddPCR assays is possible by combing probe mix and amplitude based multiplexing, which will help in developing multiplexed ddPCR assays for different SARS-CoV-2 applications.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis research was funded by the Megaproject of Infectious Disease Control from Ministry of Health of China, grant number 2017ZX10302301-005 and Sino-Africa Joint Research Center, grant number SAJC201605Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below: Wuhan Institute of Virology (WHIOV) is among the labs and institutes approved by China CDC of Wuhan city to conduct research on SARS-CoV-2 and detect COVID-19 from clinical samples. Research on developing new diagnostic techniques for COVID-19 using clinical samples has also been approved by the ethical committee of Wuhan Institute of Virology (2020FCA001). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesNo external data was used. All data is included in the manuscript
AU  - Nyaruaba, Raphael
AU  - Li, Changchang
AU  - Mwaliko, Caroline
AU  - Mwau, Matilu
AU  - Odiwuor, Nelson
AU  - Muturi, Elishiba
AU  - Muema, Caroline
AU  - Xiong, Jin
AU  - Li, Junhua
AU  - Yu, Junping
AU  - Wei, Hongping
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20207506
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20207506
ST  - Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing (preprint)
T2  - medRxiv
TI  - Developing multiplex ddPCR assays for SARS-CoV-2 detection based on probe mix and amplitude based multiplexing (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.05.20207506.abstract
ID  - 7794714
ER  - 

TY  - JOUR
AU  - Noy, Ilan
AU  - Doan, Nguyen
AU  - Taupo, Tauisi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The economic risk from COVID-19 in Pacific Island countries: very few infections but lots of pain
T2  - New Zealand Economic Papers
TI  - The economic risk from COVID-19 in Pacific Island countries: very few infections but lots of pain
UR  - https://doi.org/10.1080/00779954.2020.1827016
ID  - 7792987
ER  - 

TY  - JOUR
AU  - Norrlöf, Carla
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Is covid-19 a liberal democratic curse? Risks for liberal international order
T2  - Cambridge Review of International Affairs
TI  - Is covid-19 a liberal democratic curse? Risks for liberal international order
UR  - https://doi.org/10.1080/09557571.2020.1812529
ID  - 7792973
ER  - 

TY  - JOUR
AU  - Norman, C.
AU  - Ragad, L.
AU  - Nagarajakumar, A.
AU  - Irshad, H.
AU  - Uhercik, M.
AU  - Giono, I.
AU  - Doddi, S.
AU  - Kasem, A.
AU  - Sinha, P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - 528 Poster - Impact of COVID-19 on Breast clinic follow ups �?a new way forward?
T2  - European Journal of Cancer
TI  - 528 Poster - Impact of COVID-19 on Breast clinic follow ups �?a new way forward?
UR  - https://doi.org/10.1016/S0959-8049(20)30831-5
ID  - 7793016
ER  - 

TY  - JOUR
AU  - Noor, L.
AU  - Horn, S.
AU  - Shin, H.
AU  - Turner, E. J.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - 560 Poster - Breast referral management and outcome during COVID 19 Pandemic �?A UK experience
T2  - European Journal of Cancer
TI  - 560 Poster - Breast referral management and outcome during COVID 19 Pandemic �?A UK experience
UR  - https://doi.org/10.1016/S0959-8049(20)30862-5
ID  - 7793014
ER  - 

TY  - JOUR
AN  - 33024330
AU  - Nkengasong, J. N.
AU  - Ndembi, N.
AU  - Tshangela, A.
AU  - Raji, T.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1038/d41586-020-02774-8
DP  - NLM
ET  - 2020/10/08
IS  - 7828
J2  - Nature
KW  - Developing world
Government
SARS-CoV-2
Vaccines
LA  - eng
N1  - 1476-4687
Nkengasong, John N
Ndembi, Nicaise
Tshangela, Akhona
Raji, Tajudeen
News
England
Nature. 2020 Oct;586(7828):197-199. doi: 10.1038/d41586-020-02774-8.
PY  - 2020
SN  - 0028-0836
SP  - 197-199
ST  - COVID-19 vaccines: how to ensure Africa has access
T2  - Nature
TI  - COVID-19 vaccines: how to ensure Africa has access
VL  - 586
ID  - 7790825
ER  - 

TY  - JOUR
AB  - Patients with COVID-19 often need therapeutic interventions that are considered high aerosol-generating procedures. These are either being performed by healthcare providers with potentially inadequate personal protective equipment or the procedures are being delayed until patients clear their viral load. Both scenarios are suboptimal. We present a simple, cost-effective method of creating a portable negative pressure environment using equipment that is found in most hospitals to better protect healthcare providers and to facilitate more timely care for patients with COVID-19.
AD  - Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, Massachusetts, USA.
Tufts University School of Medicine, Boston, Massachusetts, USA.
Surgery, Tufts Medical Center, Boston, Massachusetts, USA.
Anesthesiology and Perioperative Medicine, Tufts Medical Center, Boston, Massachusetts, USA squraishi@tuftsmedicalcenter.org.
AN  - 33023899
AU  - Nilson, J.
AU  - Bugaev, N.
AU  - Sekhar, P.
AU  - Hojman, H.
AU  - Gonzalez-Ciccarelli, L.
AU  - Quraishi, S. A.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1136/bmjresp-2020-000653
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMJ open respiratory research
KW  - respiratory infection
viral infection
LA  - eng
N1  - 2052-4439
Nilson, James
Bugaev, Nikolay
Sekhar, Pavan
Hojman, Haracio
Gonzalez-Ciccarelli, Luis
Quraishi, Sadeq A
Journal Article
Review
England
BMJ Open Respir Res. 2020 Oct;7(1):e000653. doi: 10.1136/bmjresp-2020-000653.
PY  - 2020
SN  - 2052-4439
ST  - Portable negative pressure environment to protect staff during aerosol-generating procedures in patients with COVID-19
T2  - BMJ open respiratory research
TI  - Portable negative pressure environment to protect staff during aerosol-generating procedures in patients with COVID-19
VL  - 7
ID  - 7790866
ER  - 

TY  - JOUR
AB  - BACKGROUND: Immunosuppressed patients, including individuals with organ transplantation, have been among susceptible groups with regard to COVID-19, on the other hand pediatric patients more commonly undergo a mild clinical course after acquiring COVID-19. To the best of the authors knowledge, to this date very little data exists on COVID-19 in a pediatric patient with liver transplantation. CASE PRESENTATION: We report a three year-old boy who had liver transplantation at 18 months old. He was admitted due to dyspnea with impression of acute respiratory distress syndrome and was then transferred to the intensive care unit. Chest X-ray at admission showed bilateral infiltration. Vancomycin, meropenem, azithromycin, voriconazole and co-trimoxazole were started from the first day of admission. On day 4 of admission, with suspicion of COVID-19, hydroxychloroquine, lopinavir/ritonavir and oseltamivir were added to the antibiotic regimen. PCR was positive for COVID-19. The patient developed multi-organ failure and died on day 6 of admission. CONCLUSIONS: For pediatric patients with organ transplantations, extreme caution should be taken, to limit and prevent their contact with COVID-19 during the outbreak, as these patients are highly susceptible to severe forms of the disease.
AD  - Shiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz Transplant Center, Abu Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. saba_gh_m@ymail.com.
Hepatology and Nutrition Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AN  - 33023552
AU  - Nikoupour, H.
AU  - Kazemi, K.
AU  - Arasteh, P.
AU  - Ghazimoghadam, S.
AU  - Eghlimi, H.
AU  - Dara, N.
AU  - Gholami, S.
AU  - Nikeghbalian, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s12893-020-00878-6
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMC surgery
KW  - COVID-19, liver
Pediatric
Transplantation
LA  - eng
N1  - 1471-2482
Nikoupour, Hamed
Kazemi, Kourosh
Arasteh, Peyman
Ghazimoghadam, Saba
Eghlimi, Hesameddin
Dara, Naghi
Gholami, Siavash
Nikeghbalian, Saman
Journal Article
England
BMC Surg. 2020 Oct 6;20(1):224. doi: 10.1186/s12893-020-00878-6.
PY  - 2020
SN  - 1471-2482
SP  - 224
ST  - Pediatric liver transplantation and COVID-19: a case report
T2  - BMC surgery
TI  - Pediatric liver transplantation and COVID-19: a case report
VL  - 20
ID  - 7790904
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic had a significant effect in urban mobility, while essential changes are being observed in travelers&amp;rsquo;behavior Travelers in many cases shifted to other transport modes, especially walking and cycling, for minimizing the risk of infection This study attempts to investigate the impact that COVID-19 had on travelers&amp;rsquo;perceptions towards bike-sharing systems and whether the pandemic could result in a greater or lesser share of trips that are being conducted through shared bikes For that reason, a questionnaire survey was carried out in the city of Thessaloniki, Greece, and the responses of 223 people were analyzed statistically The results of the analysis show that COVID-19 will not affect significantly the number of people using bike-sharing for their trips However, for a proportion of people, bike-sharing is now more attractive Moreover, the results indicate that bike-sharing is now more likely to become a more preferable mobility option for people who were previously commuting with private cars as passengers (not as drivers) and people who were already registered users in a bike-sharing system The results also provide evidence about the importance of safety towards COVID-19 for engaging more users in bike-sharing, in order to provide them with a safe mobility option and contribute to the city&amp;rsquo;s resilience and sustainability
AU  - Nikiforiadis, Andreas
AU  - Ayfantopoulou, Georgia
AU  - Stamelou, Afroditi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Assessing the Impact of COVID-19 on Bike-Sharing Usage: The Case of Thessaloniki, Greece
T2  - Sustainability
TI  - Assessing the Impact of COVID-19 on Bike-Sharing Usage: The Case of Thessaloniki, Greece
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813244
ID  - 7793343
ER  - 

TY  - JOUR
AB  - Correct and reliable identification of SARS-CoV-2 in COVID-19 suspected patients is essential for diagnosis Respiratory samples should always be tested with real-time PCR for SARS-CoV-2 In addition, blood samples have been tested, but without consistent results and therefore the added value of this sample type is unknown The aim of this study was to determine the prevalence of SARS-CoV-2 by real-time PCR in blood samples obtained from PCR-proven COVID-19 patients and in addition to elaborate on the potential use of blood for diagnostics In this single center study, blood samples drawn from patients at the emergency department with proven COVID-19 infection based on a positive SARS-CoV-2 PCR in respiratory samples were tested for the presence of SARS-CoV-2 Samples from 118 patients were selected, of which 102 could be included in the study (median age was 65 (IQR 10), 65 7% men) In six (5 9%) of the tested samples, SARS-CoV-2 was identified by real-time PCR In conclusion, SARS-CoV-2 can be detected by real-time PCR in plasma samples from patients with proven COVID-19, but only in a minority of the patients Plasma should therefore not be used as primary sample in an acute phase setting to identify SARS-CoV-2 infection These findings are important to complete the knowledge on possible sample types to test to diagnose COVID-19
AU  - Nijhuis, R. H. T.
AU  - Russcher, A.
AU  - de Jong, G. J.
AU  - Jong, E.
AU  - Herder, G. J. M.
AU  - Remijn, J. A.
AU  - Verweij, S. P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Low prevalence of SARS-CoV-2 in plasma of COVID-19 patients presenting to the emergency department
T2  - Journal of Clinical Virology
TI  - Low prevalence of SARS-CoV-2 in plasma of COVID-19 patients presenting to the emergency department
UR  - https://doi.org/10.1016/j.jcv.2020.104655
ID  - 7793134
ER  - 

TY  - JOUR
AB  - This article is a report from an experience about a work developed by Farm֙cia Universit֙ria at UFRJ (FU-UFRJ) during the nCov-19 pandemic period. The aim of this work was to describe its contribution in the production of antiseptic supplies used to prevent contagion by the new coronavirus. The work routine at the pharmacy has been changed to allow the implementation of local workflow during the pandemic, and to adapt the protection rules to meet the safety measures. FU-UFRJ started to manipulate two antiseptic formulations: 70% ethyl alcohol and gel alcohol, which are included in the National Form, manufacturing around 100 L of these formulations, weekly, to donate to different health units. The experience enabled the adaptation to emergency health standards, planning and meaningful guidance to pharmacists and technicians to attend clinics at university hospitals, vaccination center and UFRJ city hall, in order to facilitate the access to adequate hand hygiene to the population.
AD  - Instituto de Macrom�Qleculas, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Farm֙cia Universit֙ria, Faculdade de Farm֙cia, Centro de Ci�^ncias da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
LACMAC, Faculdade de Farm֙cia, Centro de Ci�^ncias da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Farm֙cia Universit֙ria, Faculdade de Farm֙cia, Centro de Ci�^ncias da Saúde, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil. Electronic address: ricci@pharma.ufrj.br.
AN  - 33023831
AU  - Nigro, F.
AU  - Tavares, M.
AU  - Sato de Souza de Bustamante Monteiro, M.
AU  - Toma, H. K.
AU  - Faria de Freitas, Z. M.
AU  - de Abreu Gar�Qfalo, D.
AU  - Geraldes Bordalo Mont֙Alverne, M. A.
AU  - Barros Dos Passos, M. M.
AU  - Pereira Dos Santos, E.
AU  - Ricci-Júnior, E.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.sapharm.2020.09.016
DP  - NLM
ET  - 2020/10/08
J2  - Research in social & administrative pharmacy : RSAP
KW  - Actions against Covid-19
Compounding pharmacy
Coronavirus
Gels antiseptics
LA  - eng
N1  - 1934-8150
Nigro, Fiammetta
Tavares, Melanie
Sato de Souza de Bustamante Monteiro, Mariana
Toma, Helena Keiko
Faria de Freitas, Zaida Maria
de Abreu Gar�Qfalo, Denise
Geraldes Bordalo Mont֙Alverne, Maria Amélia
Barros Dos Passos, M֙rcia Maria
Pereira Dos Santos, Elisabete
Ricci-Júnior, Eduardo
Journal Article
United States
Res Social Adm Pharm. 2020 Oct 1:S1551-7411(20)31115-3. doi: 10.1016/j.sapharm.2020.09.016.
PY  - 2020
SN  - 1551-7411
ST  - Changes in workflow to a University Pharmacy to facilitate compounding and distribution of antiseptics for use against COVID-19
T2  - Research in social & administrative pharmacy : RSAP
TI  - Changes in workflow to a University Pharmacy to facilitate compounding and distribution of antiseptics for use against COVID-19
ID  - 7790874
ER  - 

TY  - JOUR
AU  - Nguyen, Oanh Thi Kim
AU  - Balakrishnan, Varsha Devi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - International students in Australia �?during and after COVID-19
T2  - Higher Education Research & Development
TI  - International students in Australia �?during and after COVID-19
UR  - https://doi.org/10.1080/07294360.2020.1825346
ID  - 7792979
ER  - 

TY  - JOUR
AB  - Public health emergency of SARS-CoV-2 has facilitated diagnostic testing as a related medical countermeasure against COVID-19 outbreak. Numerous serologic antibody tests have become available through an expedited federal emergency use only process. This paper highlights the analytical characteristic of an ELISA based assay by AnshLabs and three random access immunoassay (RAIA) by DiaSorin, Roche, and Abbott that have been approved for emergency use authorization (EUA), at a tertiary academic center in a low disease-prevalence area. The AnshLabs gave higher estimates of sero-prevalence, over the three RAIA methods. For positive results, AnshLabs had 93.3% and 100% agreement with DiaSorin or Abbott and Roche respectively. For negative results, AnshLabs had 74.3% and 78.3% agreement with DiaSorin and Roche or Abbott respectively. All discrepant samples that were positive by AnshLabs and negative by RAIA tested positive by all-in-one step SARS-CoV-2 Total (COV2T) assay performed on the automated Siemens Advia Centaur XPT analyzer. None of these methods, however, are useful in early diagnosis of SARS-CoV-2.
AD  - Department of Pathology, Baylor Scott and White Health, Temple, Texas, United States of America.
Health Texas Provider Network, Baylor Scott and White Health, Dallas, Texas, United States of America.
AN  - 33022019
AU  - Nguyen, N. N.
AU  - Mutnal, M. B.
AU  - Gomez, R. R.
AU  - Pham, H. N.
AU  - Nguyen, L. T.
AU  - Koss, W.
AU  - Rao, A.
AU  - Arroliga, A. C.
AU  - Wang, L.
AU  - Wang, D.
AU  - Hua, Y.
AU  - Powell, P. R.
AU  - Chen, L.
AU  - McCormack, C. C.
AU  - Linz, W. J.
AU  - Mohammad, A. A.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240076
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Nguyen, Nguyen N
Orcid: 0000-0002-9362-1994
Mutnal, Manohar B
Gomez, Richard R
Pham, Huy N
Nguyen, Lam T
Koss, William
Rao, Arundhati
Arroliga, Alejandro C
Wang, Liping
Wang, Dapeng
Hua, Yinan
Powell, Priscilla R
Chen, Li
McCormack, Colin C
Linz, Walter J
Mohammad, Amin A
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0240076. doi: 10.1371/journal.pone.0240076. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240076
ST  - Correlation of ELISA method with three other automated serological tests for the detection of anti-SARS-CoV-2 antibodies
T2  - PloS one
TI  - Correlation of ELISA method with three other automated serological tests for the detection of anti-SARS-CoV-2 antibodies
VL  - 15
ID  - 7790987
ER  - 

TY  - JOUR
AB  - The emergence of severe acute respiratory syndrome (SARS) in Wuhan (china) named as corona virus disease 19(covid-19) caused by the novel corona virus SARS-CoV-2 has caused hundreds of thousands of mortalities across the world ,while the mortality rate is in millions, leading it to be declared as a global pandemic. Numerous research activities are undergoing to reveal the disease and etiological features of covid-19. In this review, some of the interesting aspects of covid-19 are discussed, that includes, the origin of the SARS-CoV-2, clinical manifestation, treatment and future aspects of the disease.
AD  - Department of microbiology and Molecular Genetics, University of the Punjab, Lahore. Pakistan.
AN  - 33023459
AU  - Nawaz, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.2174/1871526520666201006163641
DP  - NLM
ET  - 2020/10/08
J2  - Infectious disorders drug targets
KW  - Ards
Covid-19
SARS-CoV-2
Transmission
Treatment
origin
LA  - eng
N1  - 2212-3989
Nawaz, Shahid
Journal Article
United Arab Emirates
Infect Disord Drug Targets. 2020 Oct 6. doi: 10.2174/1871526520666201006163641.
PY  - 2020
SN  - 1871-5265
ST  - Covid-19, SARS -CoV-2, Origin, transmission and treatment aspects, a brief review
T2  - Infectious disorders drug targets
TI  - Covid-19, SARS -CoV-2, Origin, transmission and treatment aspects, a brief review
ID  - 7790908
ER  - 

TY  - JOUR
AD  - Division of Hospital Medicine, Department of Medicine, University of California, San Francisco, CA, USA. sirisha.narayana@ucsf.edu.
Section of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, CT, USA.
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Medicine, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Division of General Internal Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Medical College of Wisconsin, Milwaukee, WI, USA.
Office of Faculty Affairs, University of Massachusetts Medical School-Baystate, Springfield, MA, USA.
AN  - 33021718
AU  - Narayana, S.
AU  - Roy, B.
AU  - Merriam, S.
AU  - Yecies, E.
AU  - Lee, R. S.
AU  - Mitchell, J. L.
AU  - Gottlieb, A. S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11606-020-06269-0
DP  - NLM
ET  - 2020/10/07
J2  - Journal of general internal medicine
LA  - eng
N1  - 1525-1497
Narayana, Sirisha
Orcid: 0000-0003-1642-7132
Roy, Brita
Merriam, Sarah
Yecies, Emmanuelle
Lee, Rita S
Mitchell, Julie L
Gottlieb, Amy S
, on behalf of the Society of General Internal Medicine’s Women and Medicine Commission
Editorial
United States
J Gen Intern Med. 2020 Oct 6. doi: 10.1007/s11606-020-06269-0.
PY  - 2020
SN  - 0884-8734
ST  - Minding the Gap: Organizational Strategies to Promote Gender Equity in Academic Medicine During the COVID-19 Pandemic
T2  - Journal of general internal medicine
TI  - Minding the Gap: Organizational Strategies to Promote Gender Equity in Academic Medicine During the COVID-19 Pandemic
ID  - 7791008
ER  - 

TY  - JOUR
AU  - Nanda, Tavish
AU  - Chen, Royce W. S.
AU  - Cioffi, George A.
AU  - Liebmann, Jeffrey M.
C1  - 10/7/2020
DA  - 2020/08
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 9
LA  - en
PY  - 2020
SP  - 723-725
ST  - Academia in Quarantine
T2  - Journal of Glaucoma
TI  - Academia in Quarantine
UR  - https://dx.doi.org/10.1097/IJG.0000000000001633
VL  - 29
ID  - 7793377
ER  - 

TY  - JOUR
AN  - 33021351
AU  - Nadolny, K.
AU  - Ładny, J. R.
AU  - Zyśko, D.
AU  - Gałązkowski, R.
AU  - Gąsior, M.
AU  - Kraska, W.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.33963/kp.15632
DP  - NLM
ET  - 2020/10/07
J2  - Kardiologia polska
LA  - eng
N1  - 1897-4279
Nadolny, Klaudiusz
Ładny, Jerzy R
Zyśko, Dorota
Gałązkowski, Robert
Gąsior, Mariusz
Kraska, Waldemar
Journal Article
Poland
Kardiol Pol. 2020 Oct 5. doi: 10.33963/KP.15632.
PY  - 2020
SN  - 0022-9032
ST  - Interventions of emergency medical teams in Poland during the SARS-CoV-2 pandemic
T2  - Kardiologia polska
TI  - Interventions of emergency medical teams in Poland during the SARS-CoV-2 pandemic
ID  - 7791037
ER  - 

TY  - JOUR
AB  - BACKGROUND: COVID-19 epidemic has paralleled with the so called infodemic, where countless pieces of information have been disseminated on putative risk factors for COVID-19. Among those, emerged the notion that people suffering from autoimmune diseases (AIDs) have a higher risk of SARS-CoV-2 infection. METHODS: The cohort included all COVID-19 cases residents in the Agency for Health Protection (AHP) of Milan that, from the beginning of the outbreak, developed a web-based platform that traced positive and negative cases as well as related contacts. AIDs subjects were defined ad having one the following autoimmune disease: rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, Sjogren disease, ankylosing spondylitis, myasthenia gravis, Hashimoto's disease, acquired autoimmune hemolytic anemia, and psoriatic arthritis. To investigate whether AID subjects are at increased risk of SARS-CoV-2 infection, and whether they have worse prognosis than AIDs-free subjects once infected, we performed a combined analysis of a test-negative design case-control study, a case-control with test-positive as cases, and one with test-negative as cases (CC-NEG). RESULTS: During the outbreak, the Milan AHP endured, up to April 27th 2020, 20,364 test-positive and 34,697 test-negative subjects. We found no association between AIDs and being positive to COVID-19, but a statistically significant association between AIDs and being negative to COVID-19 in the CC-NEG. If, as likely, test-negative subjects underwent testing because of respiratory infection symptoms, these results imply that autoimmune diseases may be a risk factor for respiratory infections in general (including COVID-19), but they are not a specific risk factor for COVID-19. Furthermore, when infected by SARS-CoV-2, AIDs subjects did not have a worse prognosis compared to non-AIDs subjects. Results highlighted a potential unbalance in the testing campaign, which may be correlated to the characteristics of the tested person, leading specific frail population to be particularly tested. CONCLUSIONS: Lack of availability of sound scientific knowledge inevitably lead unreliable news to spread over the population, preventing people to disentangle them form reliable information. Even if additional studies are needed to replicate and strengthen our results, these findings represent initial evidence to derive recommendations based on actual data for subjects with autoimmune diseases.
AD  - Epidemiology Unit, Agency for Health Protection of Milan, Corso Italia 19, 20122, Milan, Italy.
Epidemiology Unit, Agency for Health Protection of Milan, Corso Italia 19, 20122, Milan, Italy. agrusso@ats-milano.it.
AN  - 33023649
AU  - Murtas, R.
AU  - Andreano, A.
AU  - Gervasi, F.
AU  - Guido, D.
AU  - Consolazio, D.
AU  - Tunesi, S.
AU  - Andreoni, L.
AU  - Greco, M. T.
AU  - Gattoni, M. E.
AU  - Sandrini, M.
AU  - Riussi, A.
AU  - Russo, A. G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13317-020-00141-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Auto- immunity highlights
KW  - Autoimmune diseases
Covid-19
Test-negative design
LA  - eng
N1  - Murtas, Rossella
Andreano, Anita
Gervasi, Federico
Guido, Davide
Consolazio, David
Tunesi, Sara
Andreoni, Laura
Greco, Maria Teresa
Gattoni, Maria Elena
Sandrini, Monica
Riussi, Antonio
Russo, Antonio Giampiero
Orcid: 0000-0002-5681-5861
Journal Article
England
Auto Immun Highlights. 2020 Oct 6;11(1):15. doi: 10.1186/s13317-020-00141-1.
PY  - 2020
SN  - 2038-0305 (Print)
2038-0305
SP  - 15
ST  - Association between autoimmune diseases and COVID-19 as assessed in both a test-negative case-control and population case-control design
T2  - Auto- immunity highlights
TI  - Association between autoimmune diseases and COVID-19 as assessed in both a test-negative case-control and population case-control design
VL  - 11
ID  - 7790894
ER  - 

TY  - JOUR
AB  - OBJECTIVE: This study aimed to evaluate the performance, before and during the COVID-19 pandemic, of the case definition of suspected influenza used in community surveillance in Mexico. METHODS: A cross-sectional analysis of a cohort study took place and cases fulfilling the suspected case criteria (n = 20,511), and with laboratory-conclusive evidence (quantitative real-time polymerase chain reaction) to confirm or discard influenza virus infection, were analyzed. RESULTS: A high sensitivity and modest specificity were documented, and this later decreased during the COVID-19 outbreak, as well as its diagnostic accuracy. However, no significant differences were observed in the Area Under the Receiver Operating Characteristics among the analyzed periods. CONCLUSIONS: The evaluated case definition remains to be a cost-effective alternative to identify patients who may benefit from influenza-specific antiviral drugs, even during the COVID-19 global outbreak.
AD  - Departamento de Epidemiolog�Ta, Unidad de Medicina Familiar No. 19, Instituto Mexicano del Seguro Social, Colima, México.
Facultad de Ciencias, Universidad de Colima, Colima, México.
AN  - 33024341
AU  - Murillo-Zamora, E.
AU  - Hern֙ndez-Su֙rez, C.
C1  - 10/7/2020
C2  - PMC7528731
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.rce.2020.09.001
DP  - NLM
ET  - 2020/10/08
J2  - Revista clinica espanola
KW  - Covid-19
Influenza
Mexico
Pandemics
ROC Curve
LA  - spa
N1  - 1578-1860
Murillo-Zamora, E
Hern֙ndez-Su֙rez, C
Case Reports
English Abstract
Spain
Rev Clin Esp. 2020 Oct 1. doi: 10.1016/j.rce.2020.09.001.
OP  - Desempeño de la definici�Qn de caso sospechoso de influenza antes y durante la pandemia por COVID-19.
PY  - 2020
SN  - 0014-2565
ST  - [Performance of the case definition of suspected influenza before and during the COVID-19 pandemic]
T2  - Revista clinica espanola
TI  - [Performance of the case definition of suspected influenza before and during the COVID-19 pandemic]
ID  - 7790820
ER  - 

TY  - JOUR
AD  - Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA.
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA.
Horae Gene Therapy Center, University of Massachusetts Medical School, Worcester, MA, USA. guangping.gao@umassmed.edu.
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA. guangping.gao@umassmed.edu.
Li Weibo Institute for Rare Diseases Research, University of Massachusetts Medical School, Worcester, MA, USA. guangping.gao@umassmed.edu.
AN  - 33024086
AU  - Muhuri, M.
AU  - Gao, G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41392-020-00317-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
Muhuri, Manish
Gao, Guangping
Journal Article
England
Signal Transduct Target Ther. 2020 Oct 6;5(1):222. doi: 10.1038/s41392-020-00317-1.
PY  - 2020
SN  - 2059-3635
SP  - 222
ST  - Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic
T2  - Signal transduction and targeted therapy
TI  - Is smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic
VL  - 5
ID  - 7790844
ER  - 

TY  - JOUR
AB  - Objectives: To assess the transmission dynamics and the health systems burden of COVID-19 using an Agent Based Modeling (ABM) approach using a synthetic population. Study design: The study used a synthetic population with 31,738,240 agents representing 90.67 percent of the overall population of Telangana state, India as per 2011 Census of India. Lockdown phases as per Indian scenario considering the effects of post-lockdown, use of control measures and immunity on secondary infections were studied. District-level localized parameters were assigned to agents as local models prove to be much helpful for policymakers. Methods: The counts of people in different health states were measured separately for each district of Telangana. The model was run for 365 days and six scenarios with varying proportions of people using control measures (100%, 75% and 50%) and varying immunity periods of recovered patients (90 and 180 days). Results: Results indicate that the peak values were attained soon after the lockdown was lifted. The risk estimates indicate that protection factor values are higher when more proportion of people adopt control measures such as use of face mask and social distancing. Population Attributable Risk values measured longitudinally indicated higher values like 60.41% and 47.18% when 75 percent of people followed control measures during lockdowns. Conclusions: ABM approach helps to analyze grassroot details compared to compartmental models. Risk estimates allows the policymakers to determine the protection offered, its strength and percentage of population shielded by use of control measures.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis is an unfunded research activity.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NAAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesPython code and detailed resutls have all been provided in the below link.https://osf.io/3nxby/?view_only=96320e1dd7f048318294898ccd657275
AU  - Ms, Narassima
AU  - Jammy, Guru Rajesh
AU  - A, Sankarshana
AU  - Pant, Rashmi
AU  - Sp, Anbuudayasankar
AU  - Choudhury, Lincoln
AU  - Yeldandi, Vijay
AU  - Singh, Shubham
AU  - John, Denny
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206177
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206177
ST  - An Agent Based Model for assessing spread and health systems burden for COVID-19 using a synthetic population in Telangana state, India (preprint)
T2  - medRxiv
TI  - An Agent Based Model for assessing spread and health systems burden for COVID-19 using a synthetic population in Telangana state, India (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206177.abstract
ID  - 7794735
ER  - 

TY  - JOUR
AB  - [...]CDC reports that this industry has one of the highest rates of suicide of any occupation (Peterson et al., 2018). Action surrounding this component of well-being is a critical piece to fostering a safe and healthy workforce and to helping contractors manage overall risk while containing workers' compensation costs. Take Effective Actions It is essential to give all managers the training they need to identify mental health problems and play a constructive role.
AN  - 2448457166
AU  - Morton, Bruce
C1  - 10/7/2020
DA  - Oct 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; ProQuest Central
DP  - ProQuest Central
IS  - 10
KW  - Occupational Health And Safety
Health problems
Construction
Risk management
Mental health
Mental disorders
Suicide
Mental health care
Employees
Pandemics
Workers' compensation
Stigma
Injuries
Contractors
COVID-19
Coronaviruses
LA  - English
N1  - Copyright - Copyright American Society of Safety Engineers Oct 2020
PY  - 2020
SN  - 00990027
SP  - 24-25
ST  - COVID-19: ONE MORE REASON TO TAKE MENTAL HEALTH SERIOUSLY
T2  - Professional Safety
TI  - COVID-19: ONE MORE REASON TO TAKE MENTAL HEALTH SERIOUSLY
UR  - https://www.proquest.com/docview/2448457166?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=COVID-19%3A+ONE+MORE+REASON+TO+TAKE+MENTAL+HEALTH+SERIOUSLY&title=Professional+Safety&issn=00990027&date=2020-10-01&volume=65&issue=10&spage=24&au=Morton%2C+Bruce&isbn=&jtitle=Professional+Safety&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 65
ID  - 7789892
ER  - 

TY  - JOUR
AB  - Background: Given the current SARS-CoV-2 pandemic and the occurrence of a second wave, assessing the burden of disease among health care workers (HCWs) is crucial. We aim to document the prevalence of SARS-CoV-2 and the seroprevalence of anti-SARS-CoV-2 IgG among HCWs in Belgian hospitals, and to study potential risk factors for the infection in order to guide infection prevention and control (IPC) measures in healthcare institutions. Methods: We performed a cross-sectional analysis of the baseline results (April 22 - April 26) of an ongoing cohort study. All staff who were present in the hospital during the sampling period and whose profession involved contact with patients were eligible. Fourteen hospitals across Belgium and 50 HCW per hospital were randomly selected. RT-qPCR was performed to detect SARS-CoV-2 RNA on nasopharyngeal swabs, and a semi-quantitative IgG ELISA was used to detect anti-SARS-CoV-2 antibodies in sera. Individual characteristics likely to be associated with seropositivity were collected using an online questionnaire. Findings: 698 participants completed the questionnaire; 80.8% were women, median age was 39.5, and 58.5% were nurses. Samples were collected on all 699 participants. The weighted anti-SARS-CoV-2 IgG seroprevalence was 7.7% (95%CI, 4.7%-12.2%), while 1.1% (95%CI, 0.4%-3.0%) of PCR results were positive. Unprotected contact with a confirmed case was the only factor associated with seropositivity (PR 2.16, 95% CI, 1.4-3.2). Interpretation: Most Belgian HCW did not show evidence of SARS-CoV-2 infection by late April 2020, and unprotected contact was the most important risk factor. This confirms the importance of widespread availability of protective equipment and use of adequate IPC measures in hospital settings.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialClinicalTrials.gov Identifier: NCT04373889Funding StatementThis study was funded by Sciensano, the Belgian institute of public health, Brussels, Belgium. Sciensano was involved in all stages of the study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Ethical approval was granted by the Medical Ethics Committee of the University Hospital Ghent on the 8th of April 2020 (reference: B6702020000036).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesDue to confidentiality agreements, supporting data cannot be made openly available.
AU  - Mortgat, Laure
AU  - Barbezange, Cyril
AU  - Fischer, Natalie
AU  - Heyndrickx, Leo
AU  - Hutse, Veronik
AU  - Thomas, Isabelle
AU  - Vuylsteke, Bea
AU  - Arien, Kevin
AU  - Desombere, Isabelle
AU  - Duysburgh, Els
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20204545
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20204545
ST  - SARS-CoV-2 Prevalence and Seroprevalence among Healthcare Workers in Belgian Hospitals: Baseline Results of a Prospective Cohort Study (preprint)
T2  - medRxiv
TI  - SARS-CoV-2 Prevalence and Seroprevalence among Healthcare Workers in Belgian Hospitals: Baseline Results of a Prospective Cohort Study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20204545.abstract
ID  - 7794748
ER  - 

TY  - JOUR
AU  - Morote-Jayacc, Pilar V.
AU  - Sandoval, Kenyo D.
AU  - Moreno-Molina, Melissa
AU  - Taype-Rondan, Álvaro
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Estudios de salud mental en estudiantes de Medicina en el contexto de la COVID-19
T2  - Revista Colombiana de Psiquiatr�Ta
TI  - Estudios de salud mental en estudiantes de Medicina en el contexto de la COVID-19
UR  - https://doi.org/10.1016/j.rcp.2020.07.005
ID  - 7793070
ER  - 

TY  - JOUR
AB  - Background: The imperative for physical distancing during the coronavirus disease 2019 (COVID-19) pandemic may deteriorate physical and mental health. We aimed at summarizing the strength of evidence in the published literature on the association of social isolation and loneliness with physical and mental health. Methods: We conducted a systematic search in April 2020 to identify meta-analyses using the Medline, PsycINFO, and Web of Science databases. The search strategy included terms of social isolation, loneliness, living alone, and meta-analysis. Eligible meta-analyses needed to report any sort of association between an indicator of social isolation and any physical or mental health outcome. The findings were summarized in a narrative synthesis. Results: Twenty-five meta-analyses met our criteria, of which 10 focused on physical health and 15 on mental health outcomes. A total of more than 3 million individuals had participated in the 692 primary studies. The results suggest that social isolation is associated with chronic physical symptoms, frailty, coronary heart disease, malnutrition, hospital readmission, reduced vaccine uptake, early mortality, depression, social anxiety, psychosis, cognitive impairment in later life, and suicidal ideation. Conclusions: The existing evidence clearly indicates that social isolation is associated with a range of poor physical and mental health outcomes. A potential negative impact on these outcomes needs to be considered in future decisions on physical distancing measures.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding received.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This umbrella review of published meta-analyses did not require ethical approval.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data generated or analysed during this study are included in this article.
AU  - Morina, Nexhmedin
AU  - Kip, Ahlke
AU  - Hoppen, Thole H.
AU  - Priebe, Stefan
AU  - Meyer, Thomas
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.06.20207571
DP  - medRxiv
PY  - 2020
SP  - 2020.10.06.20207571
ST  - A potential impact of physical distancing on physical and mental health. A rapid narrative umbrella review of meta-analyses on the link between social isolation and health (preprint)
T2  - medRxiv
TI  - A potential impact of physical distancing on physical and mental health. A rapid narrative umbrella review of meta-analyses on the link between social isolation and health (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.06.20207571.abstract
ID  - 7794708
ER  - 

TY  - JOUR
AB  - Two vital challenges facing the world are global inequality and global climate change Solutions to both these problems are urgently needed, but, given current policies, they can potentially conflict with each other The United Nations has set 17 Sustainable Development Goals (SDGs) to be met by 2030 Even in 2019, the world was not on track for many SDGs, but the 2020 coronavirus pandemic has made their timely attainment even less likely Similarly, atmospheric carbon dioxide concentrations have continued to rise, even in the first half of 2020 Clearly, present approaches to solving both problems are not working This paper suggests several non-mainstream approaches that have the potential to address both challenges A prerequisite is deep reductions in fossil fuel energy Possible policies to achieve this include major cuts in air and car travel, shifts to a vegetarian diet, a global carbon tax and transitioning to some form of universal basic income
AU  - Moriarty, Patrick
AU  - Honnery, Damon
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - New Approaches for Ecological and Social Sustainability in a Post-Pandemic World
T2  - World
TI  - New Approaches for Ecological and Social Sustainability in a Post-Pandemic World
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813243
ID  - 7793344
ER  - 

TY  - JOUR
AB  - No specific therapy is available for COVID-19 We report the effectiveness and adverse effects of triple therapy with hydroxychloroquine, azithromycin, and ciclesonide for COVID-19 pneumonia The patient’s clinical condition improved within 5 days in response to therapy
AU  - Mori, Nobuaki
AU  - Katayama, Mitsuya
AU  - Nukaga, Shigenari
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Triple therapy with hydroxychloroquine, azithromycin, and ciclesonide for COVID-19 pneumonia
T2  - Journal of Microbiology, Immunology and Infection
TI  - Triple therapy with hydroxychloroquine, azithromycin, and ciclesonide for COVID-19 pneumonia
UR  - https://doi.org/10.1016/j.jmii.2020.09.003
ID  - 7793125
ER  - 

TY  - JOUR
AB  - The interactions between antibodies, SARS-CoV-2 and immune cells contribute to the pathogenesis of COVID-19 and protective immunity. To understand the differences between antibody responses in mild versus severe cases of COVID-19, we analyzed the B cell responses in patients 1.5 months post SARS-CoV-2 infection. Severe and not mild infection correlated with high titers of IgG against Spike receptor binding domain (RBD) that were capable of viral inhibition. B cell receptor (BCR) sequencing revealed two VH genes, VH3-38 and VH3-53, that were enriched during severe infection. Of the 22 antibodies cloned from two severe donors, six exhibited potent neutralization against live SARS-CoV-2, and inhibited syncytia formation. Using peptide libraries, competition ELISA and RBD mutagenesis, we mapped the epitopes of the neutralizing antibodies (nAbs) to three different sites on the Spike. Finally, we used combinations of nAbs targeting different immune-sites to efficiently block SARS-CoV-2 infection. Analysis of 49 healthy BCR repertoires revealed that the nAbs germline VHJH precursors comprise up to 2.7% of all VHJHs. We demonstrate that severe COVID-19 is associated with unique BCR signatures and multi-clonal neutralizing responses that are relatively frequent in the population. Moreover, our data support the use of combination antibody therapy to prevent and treat COVID-19.Competing Interest StatementThe authors have declared no competing interest.
AU  - Mor, Michael
AU  - Werbner, Michal
AU  - Alter, Joel
AU  - Safra, Modi
AU  - Chomsky, Elad
AU  - Hada-Neeman, Smadar
AU  - Polonsky, Ksenia
AU  - Nowell, Cameron
AU  - Clark, Alex
AU  - Roitburd-Berman, Anna
AU  - Ben-Shalom, Noam
AU  - Navon, Michal
AU  - Rafael, Dor
AU  - Sharim, Hila
AU  - Kiner, Evgeny
AU  - Griffis, Eric
AU  - Gershoni, Jonathan M.
AU  - Kobiler, Oren
AU  - Leibel, Sandra Lawrynowicz
AU  - Zimhony, Oren
AU  - Carlin, Aaron F.
AU  - Yaari, Gur
AU  - Dassau, Moshe
AU  - Gal-Tanamy, Meital
AU  - Hagin, David
AU  - Croker, Ben A.
AU  - Freund, Natalia
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.323634
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.323634
ST  - Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors (preprint)
T2  - bioRxiv
TI  - Multi-Clonal Live SARS-CoV-2 In Vitro Neutralization by Antibodies Isolated from Severe COVID-19 Convalescent Donors (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.323634.abstract
ID  - 7794720
ER  - 

TY  - JOUR
AD  - Hedena Health, London Road, Headington, Oxford, OX3 9JA, UK.
AN  - 33024545
AU  - Moos, B.
C1  - 10/7/2020
C2  - PMC7512477
DB  - PubMed
DP  - NLM
ET  - 2020/10/08
J2  - Journal of venom research
LA  - eng
N1  - Moos, Bethany
Journal Article
England
J Venom Res. 2020 Jul 15;10:30-31. eCollection 2020.
PY  - 2020
SN  - 2044-0324 (Print)
SP  - 30-31
ST  - Snakebite in the wake of COVID-19 - what's next?
T2  - Journal of venom research
TI  - Snakebite in the wake of COVID-19 - what's next?
VL  - 10
ID  - 7790787
ER  - 

TY  - JOUR
AB  - The Covid-19 pandemic has affected not only the health of populations but also their everyday social practices, transformed by orienting to risks of contagion and to health prevention discourses This paper emanates from a project investigating the impact of Covid-19 on human sociality and more particularly the situated and embodied organization of social interactions It discusses how Covid-19 impacts the design of ordinary actions in social interaction, how this is made publicly accountable by the participants orienting to the pandemic in formatting their actions and in responding to the actions of others Adopting an ethnomethodological and conversation analytic perspective, the analyses focus on a particular social activity: paying The organization of payments in shops and services has been affected by the pandemic, not only by official regulations, favoring some modes of payment over others, but also in how sellers and customers situatedly adapt their practices to imperatives of prevention On the basis of a rich corpus of video-recorded data, which spans from the pandemic?s prodromes to and after its peak, we show how money transfer is methodically achieved ? imposed, negotiated, and readjusted ? while variously taking into account possible risks of contagion Thus, we show not only how pandemics affect social interaction, and how prevention is incarnated in social actions, but also how, in turn, situated solutions implemented by people during the pandemic reveal fundamental features of human action
AU  - Mondada, Lorenza
AU  - Bänninger, Julia
AU  - Bouaouina, Sofian A.
AU  - Gauthier, Guillaume
AU  - Hänggi, Philipp
AU  - Koda, Mizuki
AU  - Svensson, Hanna
AU  - Tekin, Burak S.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Doing paying during the Covid-19 pandemic
T2  - Discourse Studies
TI  - Doing paying during the Covid-19 pandemic
UR  - https://doi.org/10.1177/1461445620950860
ID  - 7792809
ER  - 

TY  - JOUR
AU  - Mohammed El Tabaa, Manar
AU  - Mohammed El Tabaa, Maram
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Corrigendum to “Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost�?[Biochem. Pharmacol. 178 (2020) 114057]
T2  - Biochemical Pharmacology
TI  - Corrigendum to “Targeting Neprilysin (NEP) pathways: A potential new hope to defeat COVID-19 ghost�?[Biochem. Pharmacol. 178 (2020) 114057]
UR  - https://doi.org/10.1016/j.bcp.2020.114249
ID  - 7793224
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Most reports on the declining incidence of myocardial infarction (MI) during the COVID-19 have either been anecdotal, survey results or geographically limited to areas with lockdowns. We examined the incidence of MI during the COVID-19 pandemic in Sweden, which has remained an open society with a different public health approach fighting COVID-19. METHODS: We assessed the incidence rate (IR) as well as the incidence rate ratios (IRRs) of all MI referred for coronary angiography in Sweden using the nationwide Swedish Coronary Angiography and Angioplasty Registry (SCAAR), during the COVID-19 pandemic in Sweden (1 March 2020-7 May 2020) in relation to the same days 2015-2019. RESULTS: A total of 2443 MIs were referred for coronary angiography during the COVID-19 pandemic resulting in an IR 36 MIs/day (204 MIs/100�?00 per year) compared with 15 213 MIs during the reference period with an IR of 45 MIs/day (254 MIs/100�?00 per year) resulting in IRR of 0.80, 95% CI (0.74 to 0.86), p0.001. Results were consistent in all investigated patient subgroups, indicating no change in patient category seeking cardiac care. Kaplan-Meier event rates for 7-day case fatality were 439 (2.3%) compared with 37 (2.9%) (HR: 0.81, 95% CI (0.58 to 1.13), p=0.21). Time to percutaneous coronary intervention (PCI) was shorter during the pandemic and PCI was equally performed, indicating no change in quality of care during the pandemic. CONCLUSION: The COVID-19 pandemic has significantly reduced the incidence of MI referred for invasive treatment strategy. No differences in overall short-term case fatality or quality of care indicators were observed.
AD  - Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden.
Department of Cardiology, Linköping University, Linköping, Sweden.
Department of Medicine, Växjö Hospital, Växjö, Sweden.
Department of Cardiology, Department of Molecular and Clinical Medicine, Department of Cardiology, Sahlgrenska University Hospital, Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden.
Department of Cardiology, Östersund Hospital, Östersund, Sweden.
Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
Department of Medical Sciences and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
Department of Internal Medicine, Västmanlands Sjuk, Lund, Sweden.
Division of Cardiovascular Medicine, Department of Clinical Sciences, Karolinska Institutet, Danderyd University Hospital, Stockolm, Sweden.
Dvision of Cardiology, Department of Clinical Science and Education, Karolinska Institute, Södersjukhuset, Stockholm, Sweden.
Department of Clinical Physiology, Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden.
Department of Cardiology, Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden david.erlinge@gmail.com.
AN  - 33023905
AU  - Mohammad, M. A.
AU  - Koul, S.
AU  - Olivecrona, G. K.
AU  - G�ttberg, M.
AU  - Tydén, P.
AU  - Rydberg, E.
AU  - Scherstén, F.
AU  - Alfredsson, J.
AU  - Vasko, P.
AU  - Omerovic, E.
AU  - Angerås, O.
AU  - Fröbert, O.
AU  - Calais, F.
AU  - Völz, S.
AU  - Ulvenstam, A.
AU  - Venetsanos, D.
AU  - Yndigegn, T.
AU  - Oldgren, J.
AU  - Sarno, G.
AU  - Grimfjärd, P.
AU  - Persson, J.
AU  - Witt, N.
AU  - Ostenfeld, E.
AU  - Lindahl, B.
AU  - James, S. K.
AU  - Erlinge, D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/heartjnl-2020-317685
DP  - NLM
ET  - 2020/10/08
J2  - Heart (British Cardiac Society)
KW  - acute myocardial infarction
epidemiology
LA  - eng
N1  - 1468-201x
Mohammad, Moman A
Orcid: 0000-0003-4242-9801
Koul, Sasha
Olivecrona, Göran K
G�ttberg, Matthias
Tydén, Patrik
Rydberg, Erik
Scherstén, Fredrik
Alfredsson, Joakim
Vasko, Peter
Omerovic, Elmir
Angerås, Oskar
Fröbert, Ole
Orcid: 0000-0002-5846-345x
Calais, Fredrik
Völz, Sebastian
Ulvenstam, Anders
Venetsanos, Dimitrios
Orcid: 0000-0001-5263-875x
Yndigegn, Troels
Oldgren, Jonas
Sarno, Giovanna
Grimfjärd, Per
Persson, Jonas
Witt, Nils
Ostenfeld, Ellen
Lindahl, Bertil
James, Stefan K
Erlinge, David
Journal Article
England
Heart. 2020 Oct 6:heartjnl-2020-317685. doi: 10.1136/heartjnl-2020-317685.
PY  - 2020
SN  - 1355-6037
ST  - Incidence and outcome of myocardial infarction treated with percutaneous coronary intervention during COVID-19 pandemic
T2  - Heart (British Cardiac Society)
TI  - Incidence and outcome of myocardial infarction treated with percutaneous coronary intervention during COVID-19 pandemic
ID  - 7790865
ER  - 

TY  - JOUR
AB  - Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, has spread throughout the world Coagulation dysfunction is one of the major causes of death in patients with severe COVID-19 Several recent observations in Algeria and elsewhere maintain that a pulmonary embolism is frequent in patients with COVID-19 with a high incidence in intensive care In addition, other studies have shown that many deceased patients have diagnostic criteria for disseminated intravascular coagulation (DIC) set by the International Society of Hemostasis and Thrombosis (ISTH) The office of the Algerian Society of Transfusion and Hemobiology composed of hemostasis and blood transfusion experts from Algerian hospitals on the epidemic front line have established a consensus on the issue through 4 axes: Indication of thromboprophylaxis, monitoring of hemostasis, indications of transfusion in the event of Disseminated Intravascular Coagulation (DIC) and anticoagulant treatment after discharge
AU  - Mohamed, Chekkal
AU  - Tahra, Deba
AU  - Soraya, Hadjali
AU  - Hassiba, Lamara
AU  - Hanifa, Oulaa
AU  - Karima, Zouai
AU  - Ghania, Hariti
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Prevention and treatment of COVID-19-associated hypercoagulability: recommendations of the Algerian society of transfusion and hemobiology
T2  - Transfusion Clinique et Biologique
TI  - Prevention and treatment of COVID-19-associated hypercoagulability: recommendations of the Algerian society of transfusion and hemobiology
UR  - https://doi.org/10.1016/j.tracli.2020.09.004
ID  - 7793046
ER  - 

TY  - JOUR
AU  - Mobrick, Mustafa
C1  - 10/7/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 2
LA  - it
PY  - 2020
SP  - 65-68
ST  - Negoziare il periodo successivo al Covid19: sostenere le comunità di pratica
T2  - Prof Inferm
TI  - Negoziare il periodo successivo al Covid19: sostenere le comunità di pratica
TT  - [Negotiating the Post Covid19 Period: Making the Case for Communities of Practice].
UR  - https://dx.doi.org/10.7429/pi.2020.732065
VL  - 73
ID  - 7794111
ER  - 

TY  - JOUR
AB  - BACKGROUND: Due to spread and impact of COVID-19 in the world and Turkey lead to fear, stress and anxiety in individuals. This trend is increasing more especially in pregnant women at risk as they are concerned about the safety of themselves and the fetus. AIM: In our study, concerns, problems and attitudes of pregnant women related to diseases in the pandemic process will be determined by detailed discussions based on their individual experience, and by increasing the awareness of midwives and nurses about what pregnant women experience in this process. METHODS: Content analysis is used as qualitative study pattern. Due to the social isolation rules during the coronavirus pandemic, interviews with pregnant women were planned to be held via mobile phone. The study was completed with 15 pregnant women. RESULTS: As a result of the content analysis of the interviews, 3 main themes and 11 sub-themes were identified. The identified themes were as following: (1) not understanding the seriousness and fear of the unknown, (2) coronavirus pandemic and disruption of the routine prenatal care (3) disrupted routines and social lives. Each theme was necessarily discussed separately. CONCLUSION: The results of the study show that coronavirus pandemic has a significant potential for creating anxiety, adversity and fear, which has a negative emotional effect on pregnant people. It will be useful to provide awareness for midwives and nurses not only about the physical health of pregnant women, but also their mental health, and to cooperate with mental health experts if necessary.
AD  - Eskisehir Osmangazi University, Faculty of Health Sciences, Nursing Department, Eskisehir, Turkey. Electronic address: bmizrak@ogu.edu.tr.
Eskisehir Osmangazi University, Faculty of Health Sciences, Midwifery Department, Eskisehir, Turkey.
AN  - 33023829
AU  - Mizrak Sahin, B.
AU  - Kabakci, E. N.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.wombi.2020.09.022
DP  - NLM
ET  - 2020/10/08
J2  - Women and birth : journal of the Australian College of Midwives
KW  - Attitude
Covid-19
Concerns
Experiences
Pregnancy
Turkey
LA  - eng
N1  - 1878-1799
Mizrak Sahin, Berrak
Kabakci, Esra Nur
Journal Article
Netherlands
Women Birth. 2020 Oct 1:S1871-5192(20)30340-1. doi: 10.1016/j.wombi.2020.09.022.
PY  - 2020
SN  - 1871-5192
ST  - The experiences of pregnant women during the COVID-19 pandemic in Turkey: A qualitative study
T2  - Women and birth : journal of Australian College of Midwives
TI  - The experiences of pregnant women during the COVID-19 pandemic in Turkey: A qualitative study
ID  - 7790875
ER  - 

TY  - JOUR
AU  - Mirante, Vincenzo Giorgio
AU  - Mazzi, Giorgio
AU  - Bevivino, Gerolamo
AU  - Parmeggiani, Francesca
AU  - Iori, Giorgio
AU  - Sassatelli, Romano
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - How an endoscopy unit changed and was partially converted into an ICU during COVID-19 emergency in a tertiary referral hospital of Northern Italy
T2  - Digestive and Liver Disease
TI  - How an endoscopy unit changed and was partially converted into an ICU during COVID-19 emergency in a tertiary referral hospital of Northern Italy
UR  - https://doi.org/10.1016/j.dld.2020.09.029
ID  - 7793190
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Diabetes may unfavorably influence the outcome of coronavirus disease 19 (COVID-19), but the determinants of this effect are still poorly understood. In this monocentric study, we aimed at evaluating the impact of type 2 diabetes, comorbidities, plasma glucose levels, and antidiabetes medications on the survival of COVID-19 patients. RESEARCH DESIGN AND METHODS: This was a case series involving 387 COVID-19 patients admitted to a single center in the region of Lombardy, the epicenter of the severe acute respiratory syndrome coronavirus 2 pandemic in Italy, between 20 February and 9 April 2020. Medical history, pharmacological treatments, laboratory findings, and clinical outcomes of patients without diabetes and patients with type 2 diabetes were compared. Cox proportional hazards analysis was applied to investigate risk factors associated with mortality. RESULTS: Our samples included 90 patients (23.3%) with type 2 diabetes, who displayed double the mortality rate of subjects without diabetes (42.3% vs. 21.7%, P  0.001). In spite of this, after correction for age and sex, risk of mortality was significantly associated with a history of hypertension (adjusted hazard ratio [aHR] 1.84, 95% CI 1.15-2.95; P = 0.011), coronary artery disease (aHR 1.56, 95% CI 1.04-2.35; P = 0.031), chronic kidney disease (aHR 2.07, 95% CI 1.27-3.38; P = 0.003), stroke (aHR 2.09, 95% CI 1.23-3.55; P = 0.006), and cancer (aHR 1.57, 95% CI 1.08-2.42; P = 0.04) but not with type 2 diabetes (P = 0.170). In patients with diabetes, elevated plasma glucose (aHR 1.22, 95% CI 1.04-1.44, per mmol/L; P = 0.015) and IL-6 levels at admission (aHR 2.47, 95% CI 1.28-4.78, per 1-SD increase; P = 0.007) as well as treatments with insulin (aHR 3.05, 95% CI 1.57-5.95; P = 0.001) and β-blockers (aHR 3.20, 95% CI 1.50-6.60; P = 0.001) were independently associated with increased mortality, whereas the use of dipeptidyl peptidase 4 inhibitors was significantly and independently associated with a lower risk of mortality (aHR 0.13, 95% CI 0.02-0.92; P = 0.042). CONCLUSIONS: Plasma glucose levels at admission and antidiabetes drugs may influence the survival of COVID-19 patients affected by type 2 diabetes.
AD  - Endocrinology and Diabetology Unit, Humanitas Clinical and Research Center, IRCCS, Milan, Italy marco.mirani@humanitas.it.
Endocrinology and Diabetology Unit, Humanitas Clinical and Research Center, IRCCS, Milan, Italy.
Biostatistics Unit, Humanitas Clinical and Research Center, IRCCS, Milan, Italy.
Department of Biomedical Sciences, Humanitas University, Milan, Italy.
AN  - 33023989
AU  - Mirani, M.
AU  - Favacchio, G.
AU  - Carrone, F.
AU  - Betella, N.
AU  - Biamonte, E.
AU  - Morenghi, E.
AU  - Mazziotti, G.
AU  - Lania, A. G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.2337/dc20-1340
DP  - NLM
ET  - 2020/10/08
J2  - Diabetes care
LA  - eng
N1  - 1935-5548
Mirani, Marco
Favacchio, Giuseppe
Orcid: 0000-0002-4187-5378
Carrone, Flaminia
Betella, Nazarena
Biamonte, Emilia
Morenghi, Emanuela
Mazziotti, Gherardo
Lania, Andrea Gerardo
Journal Article
United States
Diabetes Care. 2020 Oct 6:dc201340. doi: 10.2337/dc20-1340.
PY  - 2020
SN  - 0149-5992
ST  - Impact of Comorbidities and Glycemia at Admission and Dipeptidyl Peptidase 4 Inhibitors in Patients With Type 2 Diabetes With COVID-19: A Case Series From an Academic Hospital in Lombardy, Italy
T2  - Diabetes care
TI  - Impact of Comorbidities and Glycemia at Admission and Dipeptidyl Peptidase 4 Inhibitors in Patients With Type 2 Diabetes With COVID-19: A Case Series From an Academic Hospital in Lombardy, Italy
ID  - 7790855
ER  - 

TY  - JOUR
AU  - Mintz, J.
AU  - Huntley, K.
AU  - Wahood, W.
AU  - Raine, S.
AU  - Hardigan, P.
AU  - Haffizulla, F.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Early Government Interventions are Correlated to Lower Peak COVID-19 Outcomes
T2  - Annals of Epidemiology
TI  - Early Government Interventions are Correlated to Lower Peak COVID-19 Outcomes
UR  - https://doi.org/10.1016/j.annepidem.2020.08.036
ID  - 7793233
ER  - 

TY  - JOUR
AB  - We aimed to determine the hospitalization rate and average days spent at home in a population of assisted living (AL) residents served by a home-based primary care (HBPC) practice during the COVID-19 pandemic We provided on-site HBPC to 1,699 AL residents and calculated hospitalization rate and days spent at home The AL population had a mean age of 84 �u 10?years and 73% were female The mean hospitalization rate was 449 admissions per 1,000?per year, and there was wide variation among AL communities AL residents spent a mean of 358?days at home per year, and the average days spent at home varied during the COVID-19 pandemic Use of these measures may help AL articulate its value proposition by enabling seniors with complex health needs to live in community settings for as many days as possible
AU  - Mills, William R.
AU  - Buccola, Janet M.
AU  - Roosa, Jamie
AU  - Lemin, Lisa
AU  - Cappelli, Lynn
AU  - Schraer, Belinda
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Variation in Value-Based Outcome Measures Among Assisted Living Communities Served by a Home-Based Primary Care Practice During COVID-19
T2  - Home Health Care Management & Practice
TI  - Variation in Value-Based Outcome Measures Among Assisted Living Communities Served by a Home-Based Primary Care Practice During COVID-19
UR  - https://doi.org/10.1177/1084822320963094
ID  - 7792811
ER  - 

TY  - JOUR
AB  - BACKGROUND: Isolation space must be expanded during pandemics involving airborne transmission. Little to no work has been done to establish optimal design strategies and implementation plans to ease surge capacity and expand isolation capacity over long periods in congregate living facilities. The COVID-19 pandemic has an airborne transmission component and requires isolation, which is difficult to accomplish in skilled nursing facilities. PURPOSE: In this study we designed, implemented, and validated an isolation space at a skilled nursing facility in Lancaster, PA. The overall goal was to minimize disease transmission between residents and staff within the facility. BASIC PROCEDURES: We created an isolation space by modifying an existing HVAC system of the SNF. We measured pressure on-site and performed computational fluid dynamics and Lagrangian particle-based modeling to test containment and possible transmission extent given the isolation space is considered negative rather than individual rooms. MAIN FINDINGS: Pressure data shows the isolation space maintained an average (standard deviation) hourly value of -2.3 Pa (0.12 Pa) pressure differential between it and the external hallway connected to the rest of the facility. No transmission of SARS-CoV-2 between residents isolated to the space occurred, nor did any transmission to the staff or other residents occur. The isolation space was successfully implemented and, as of writing, continues to be operational through the pandemic.
AD  - Mechanical Engineering, Environmental Engineering Program, University of Colorado Boulder, Boulder, Colorado, United States of America. Electronic address: shelly.miller@colorado.edu.
Mechanical Engineering, Environmental Engineering Program, University of Colorado Boulder, Boulder, Colorado, United States of America.
Well Living Lab, Rochester, Minnesota, United States of America; Mayo Clinic, General Internal Medicine, Rochester, Minnesota, United States of America.
The College of Business and Leadership, Eastern University, St. Davids, Pennsylvania, United States of America.
AN  - 33022331
AU  - Miller, S.
AU  - Mukherjee, D.
AU  - Wilson, J.
AU  - Clements, N.
AU  - Steiner, C.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.ajic.2020.09.014
DP  - NLM
ET  - 2020/10/07
J2  - American journal of infection control
KW  - aerosol transmission
airborne transmission
congregate living facilities
engineering controls
surge capacity
LA  - eng
N1  - 1527-3296
Miller, Shelly
Mukherjee, Debanjan
Wilson, Joseph
Clements, Nicholas
Steiner, Cedric
Journal Article
United States
Am J Infect Control. 2020 Oct 3:S0196-6553(20)30894-4. doi: 10.1016/j.ajic.2020.09.014.
PY  - 2020
SN  - 0196-6553
ST  - Implementing a Negative Pressure Isolation Space within a Skilled Nursing Facility to Control SARS-CoV-2 Transmission
T2  - American journal of infection control
TI  - Implementing a Negative Pressure Isolation Space within a Skilled Nursing Facility to Control SARS-CoV-2 Transmission
ID  - 7790966
ER  - 

TY  - JOUR
AB  - The scope of health information and health care services available online is rapidly expanding. At the same time, COVID-19 is causing vulnerable elders to reconsider in-person provider visits. In that context, recently published research by Y. Mizrachi et al. examining obstacles to the use of online health services (OHS) among adults age 50 and up takes on new importance. An iconic Israeli song begins, "Will you hear my voice?" (Hebrew Songs. Zemer Nugeh (Hatishmah Koli), 2020). What makes Mizrachi et al.'s findings particularly intriguing, despite several caveats, is the manner in which they demonstrated a commitment to genuinely listen to individual voices. The researchers spoke "openly and bluntly" with interviewees as peers and were rewarded with "specific, well-defined and applicable answers with the potential to be used." The most striking findings came in candid answers that went beyond the factors intrinsic to the online offerings and addressed important factors in what regular Internet users often refer to as IRL ("in real life"), such as support from family. The necessity of avoiding preconceptions about the most effective manner to engage patients underscores the importance of patient and family advisory councils (PFACs). PFACs, increasingly being adopted by health care organizations globally, provide an ongoing ability to listen and respond to the "patient voice." Effectively addressing obstacles to older adults' use of the full range of online health resources will require the involvement not just of health plans and government, but also of voluntary organizations, providers, families and others integral to users' offline "real lives." Sustained, focused listening must be a central part of that effort.
AD  - Northwestern University Feinberg School of Medicine, Chicago, IL, USA and Health Quality Advisors LLC, Highland Park, IL, USA. m-millenson@northwestern.edu.
AN  - 33023660
AU  - Millenson, M. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13584-020-00408-y
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Israel journal of health policy research
KW  - Covid-19
Consumerism
Digital exclusion
HMOs
Internet health
Older adults
Online health services
Patient and family advisory councils (PFACs)
Patient engagement
Patient portals
Patient-centered care
LA  - eng
N1  - 2045-4015
Millenson, Michael L
Orcid: 0000-0001-8364-1927
Journal Article
England
Isr J Health Policy Res. 2020 Oct 6;9(1):51. doi: 10.1186/s13584-020-00408-y.
PY  - 2020
SN  - 2045-4015
SP  - 51
ST  - "Will you hear my voice?": to engage older patients online, listen to them about their lives offline
T2  - Israel journal of health policy research
TI  - "Will you hear my voice?": to engage older patients online, listen to them about their lives offline
VL  - 9
ID  - 7790893
ER  - 

TY  - JOUR
AB  - L’épidémie due au coronavirus, qui a contraint la population au confinement pendant deux mois, a eu un impact sur la pratique des professionnels de santé, et notamment sur celle des sages-femmes Les grossesses n’ont pas attendu la fin de la crise sanitaire pour se mettre en route ou arriver à leur terme, et la santé génésique des patientes a d�] �^tre préservée La téléconsultation a permis de maintenir le contact avec les femmes désireuses d’obtenir une grossesse, de la poursuivre ou non, et d’assurer leur surveillance et leur prise en charge, malgré les distances Teleconsultation, a new tool for midwifery practice coronavirus epidemic that forced the population into a two-month lockdown has had an impact on the practice of health professionals and particularly on that of midwives Pregnancies did not wait for the end of the health crisis to start or reach term, and the reproductive health of patients had to be preserved The teleconsultation made it possible to maintain contact with women who wished to become pregnant, whether or not to go on with the pregnancy, and to ensure their monitoring and care, despite the distances involved
AU  - Migeon, Pierre-Antoine
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - La téléconsultation, un nouvel outil pour la pratique sage-femme
T2  - Sages-Femmes
TI  - La téléconsultation, un nouvel outil pour la pratique sage-femme
UR  - https://doi.org/10.1016/j.sagf.2020.07.005
ID  - 7793056
ER  - 

TY  - JOUR
AB  - COVID19 challenges every dimension of public health systems, from research and health care treatment to public communication, coercive mechanisms such as quarantine, and respect for individual rights This round table has 3 key objectives: To understand patterns in responses across countries, and in particular the different ways that authoritarian and democratic regimes responded;To identify comparative lessons for understanding the European experience from other high-income health systems;To draw conclusions about the politics of effective public health intervention and likely lessons of COVID19 Burris will present on how although initial control efforts took the form of travel restrictions, quarantine and isolation, sustained human-to-human community transmission of COVID-19 in the United States pushed authorities to move from these traditional tools to the challenge of promoting social distancing behavior and managing a surge in demand for health care These challenges posed new and urgent questions of practical regulation and distributive justice as underlying social disparities created differing levels of vulnerability This presentation reviews the first six months of the response in the US from a legal and social justice standpoint, focusing on issues of equity Fafard will analyze the communications role of senior public health officials during the COVID-19 outbreak in five countries;their public messaging across a range of media platforms, including how they deal with misinformation;and the extent to which members of the public receive, understand, and trust this messaging Kavanagh will discuss how relative democratic and autocratic political institutions have influenced early responses to the novel coronavirus outbreak Using evidence from process tracing in China, Iran, the United States, South Korea, and Italy, this presentation evaluates the hypothesis advanced or implied by many global public health officials that authoritarian governments have an advantage in disease response Peralta will discuss how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic highlighted the heterogeneity in the measured used for containment and mitigation by governments Where authoritarian states, that theoretically have more policy options for containment and mitigation, have an advantage in an epidemic event remains unclear This presentation will compare measures taken by governments and health authorities in five selected authoritarian states and five democracies and evaluate the capacity of epidemic containment Willison will highlight how political elites in the United States define public health threats;how partisanship and party competition define public health responses, including expenditure and coordination;and how party and media elites draw on established tensions in American politics to frame outbreaks in ways advantageous to the parties Key messages We will focus on similarities and differences in responses to COVID-19 around the world, highlight effective measures, and reflect on lessons learned in the first few months of this novel coronavirus We will draw attention to issues of human rights and health equity among government responses
AU  - Michigan, Organised by University of
AU  - Chair persons: Elizabeth J King - Usa, Scott Greer U. S. A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - 6.A. Round table: Protecting borders and preparing for a pandemic: responses around the world to COVID19
T2  - European Journal of Public Health
TI  - 6.A. Round table: Protecting borders and preparing for a pandemic: responses around the world to COVID19
UR  - https://doi.org/10.1093/eurpub/ckaa165.283
ID  - 7792917
ER  - 

TY  - JOUR
AB  - The pandemic is creating unprecedented demand for mental health support for young people. While schools often facilitate mental health support for their students, the demands for online teaching and the uncertainty created by the pandemic make traditional delivery of support through schools challenging. Technology provides a potential way forward. We have developed a digital ecosystem, HABITS, that can be integrated into school and healthcare systems. This has allowed us to deploy specific evidence-based interventions directly, and through schools, to students and to parents in New Zealand during the current pandemic. Chatbot architecture is particularly suited to rapid iteration to provide specific information while apps can provide more generalised support. While technology can provide some solutions, it is important to be aware of the potential to increase current inequities, with those facing the greatest challenges to health and well-being, also least able to afford the resources to access digital interventions. Development of an integrated and equitable digital system will take time and collaboration.
AD  - Department of Psychological Medicine, University of Auckland, Auckland, New Zealand.
School of Health, Victoria University of Wellington, Wellington, New Zealand.
School of Computer Science, University of Auckland, Auckland, New Zealand.
AN  - 33025729
AU  - Merry, S. N.
AU  - Cargo, T.
AU  - Christie, G.
AU  - Donkin, L.
AU  - Hetrick, S.
AU  - Fleming, T.
AU  - Holt-Quick, C.
AU  - Hopkins, S.
AU  - Stasiak, K.
AU  - Warren, J.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1111/camh.12429
DP  - NLM
ET  - 2020/10/08
J2  - Child and adolescent mental health
LA  - eng
N1  - Merry, Sally N
Orcid: 0000-0002-8281-1573
Cargo, Tania
Christie, Grant
Donkin, Liesje
Hetrick, Sarah
Fleming, Terry
Holt-Quick, Chester
Hopkins, Sarah
Orcid: 0000-0002-4705-5362
Stasiak, Karolina
Warren, Jim
Ministry of Business Innovation and Employment New Zealand/
Cure Kids/
Journal Article
England
Child Adolesc Ment Health. 2020 Oct 7. doi: 10.1111/camh.12429.
PY  - 2020
SN  - 1475-357X (Print)
1475-357x
ST  - Debate: Supporting the mental health of school students in the COVID-19 pandemic in New Zealand - a digital ecosystem approach
T2  - Child and adolescent mental health
TI  - Debate: Supporting the mental health of school students in the COVID-19 pandemic in New Zealand - a digital ecosystem approach
ID  - 7790682
ER  - 

TY  - JOUR
AN  - PMC7536125
AU  - Melikov, Arsen K.
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.buildenv.2020.107336
DP  - NLM
J2  - Build Environ
LA  - eng
N1  - PMC7536125[pmcid]
S0360-1323(20)30705-8[PII]
PY  - 2020
SN  - 0360-1323
1873-684X
SP  - 107336
ST  - COVID-19: Reduction of airborne transmission needs paradigm shift in ventilation
T2  - Building and Environment
TI  - COVID-19: Reduction of airborne transmission needs paradigm shift in ventilation
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536125/
ID  - 7790680
ER  - 

TY  - JOUR
AB  - The tourism industry faces multiple changes (economic crises, climate change, technology innovation�?. Because of this vulnerability, as evidenced by the COVID-19 pandemic, the study of hotel resilience is a key issue for the survival and competitiveness of organisations and destinations. Therefore, this paper proposes a holistic model to measure organisational resilience. To that end, it aims to analyse the determinants of organisational resilience, i.e. predictors of resilience (strategy and change), and to assess how they contribute to hotel resilience and performance. Firstly, the hotel context in the Canary Islands is examined to identify the level of impact, frequency and predictability of each type of change. Secondly, scales development and validation were conducted. Finally, the proposed model is validated. Findings confirm that the strategy and change dimensions have a considerable effect on hotel resilience, which positively influences hotel performance. Discussion provides hotel managers with guidelines to improve organisational resilience and performance.
AD  - Universidad de Las Palmas de Gran Canaria, Spain.
AN  - 33024657
AU  - Meli֙n-Alzola, L.
AU  - Fern֙ndez-Monroy, M.
AU  - Hidalgo-Peñate, M.
C1  - 10/7/2020
C2  - PMC7529406
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.tmp.2020.100747
DP  - NLM
ET  - 2020/10/08
J2  - Tourism management perspectives
KW  - Change
Crisis
Hotel
Performance
Resilience
Tourism
Vulnerability
LA  - eng
N1  - 2211-9744
Meli֙n-Alzola, Luc�Ta
Fern֙ndez-Monroy, Margarita
Hidalgo-Peñate, Marisa
Journal Article
England
Tour Manag Perspect. 2020 Oct;36:100747. doi: 10.1016/j.tmp.2020.100747. Epub 2020 Oct 1.
PY  - 2020
SN  - 2211-9736
SP  - 100747
ST  - Hotels in contexts of uncertainty: Measuring organisational resilience
T2  - Tourism management perspectives
TI  - Hotels in contexts of uncertainty: Measuring organisational resilience
VL  - 36
ID  - 7790779
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To develop a score to predict the need for intensive care unit (ICU) admission in Covid-19. MATERIALS AND METHODS: We assessed patients admitted to a Covid-19 center in Mexico. Patients were segregated into a group that required ICU admission, and a group that never required ICU admission. By logistic regression, we derived predictive models including clinical, laboratory, and imaging findings. The ABC-GOALS was constructed and compared to other scores. RESULTS: We included 329 and 240 patients in the development and validation cohorts, respectively. Onehundred- fifteen patients from each cohort required ICU admission. The clinical (ABC-GOALSc), clinical+laboratory (ABC-GOALScl), clinical+laboratory+image (ABC-GOALSclx) models area under the curve were 0.79 (95%CI=0.74-0.83) and 0.77 (95%CI=0.71-0.83), 0.86 (95%CI=0.82-0.90) and 0.87 (95%CI=0.83-0.92), 0.88 (95%CI=0.84-0.92) and 0.86 (95%CI=0.81-0.90), in the development and validation cohorts, respectively. The ABC-GOALScl and ABC-GOALSclxoutperformed other Covid-19 and pneumonia predictive scores. CONCLUSIONS: ABC-GOALS is a tool to timely predict the need for admission to ICU in Covid-19.
AD  - Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrici�Qn Salvador Zubir֙n. Mexico City, Mexico.
Department of Critical Care Medicine, Instituto Nacional de Cancerolog�Ta. Mexico City, Mexico.
Emergency Department, Instituto Nacional de Ciencias Médicas y Nutrici�Qn Salvador Zubir֙n. Mexico City, Mexico.
AN  - 33021362
AU  - Mej�Ta-Vilet, J. M.
AU  - C�Qrdova-S֙nchez, B. M.
AU  - Fern֙ndez-Camargo, D. A.
AU  - Méndez-Pérez, R. A.
AU  - Morales-Buenrostro, L. E.
AU  - Hern֙ndez-Gilsoul, T.
C1  - 10/7/2020
DA  - Oct 10
DB  - PubMed
DO  - 10.21149/11684
DP  - NLM
ET  - 2020/10/07
J2  - Salud publica de Mexico
KW  - Covid-19
coronavirus
intensive care
pandemic
prediction
of interests.
LA  - eng
N1  - 1606-7916
Mej�Ta-Vilet, Juan M
C�Qrdova-S֙nchez, Bertha M
Fern֙ndez-Camargo, Dheni A
Méndez-Pérez, R Angélica
Morales-Buenrostro, Luis E
Hern֙ndez-Gilsoul, Thierry
Journal Article
Mexico
Salud Publica Mex. 2020 Oct 10. doi: 10.21149/11684.
OP  - Puntaje de riesgo para predecir el ingreso a una unidad de cuidados intensivos en pacientes con Covid-19: puntaje ABC-GOALS.
PY  - 2020
SN  - 0036-3634
ST  - A risk score to predict admission to the intensive care unit in patients with Covid-19: the ABC-GOALS score
T2  - Salud publica de Mexico
TI  - A risk score to predict admission to the intensive care unit in patients with Covid-19: the ABC-GOALS score
ID  - 7791036
ER  - 

TY  - JOUR
AD  - Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India.
Department of Pediatrics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, 110002, India. pallavi86.delhi@gmail.com.
Department of Microbiology, Kalawati Saran Children's Hospital & Lady Hardinge Medical Hospital, New Delhi, India.
AN  - 33025514
AU  - Meena, P.
AU  - Pallavi
AU  - Mishra, D.
AU  - Jhamb, U.
AU  - Aggarwal, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s12098-020-03509-3
DP  - NLM
ET  - 2020/10/08
J2  - Indian journal of pediatrics
LA  - eng
N1  - 0973-7693
Meena, Priyanka
Pallavi
Mishra, Devendra
Jhamb, Urmila
Aggarwal, Meenakshi
Letter
India
Indian J Pediatr. 2020 Oct 6. doi: 10.1007/s12098-020-03509-3.
PY  - 2020
SN  - 0019-5456
ST  - Low-Dose Dexamethasone Following IVIG in Pediatric Inflammatory Multisystem Syndrome in Temporal Association with COVID-19 (PIMS-TC)
T2  - Indian journal of pediatrics
TI  - Low-Dose Dexamethasone Following IVIG in Pediatric Inflammatory Multisystem Syndrome in Temporal Association with COVID-19 (PIMS-TC)
ID  - 7790700
ER  - 

TY  - GEN
AN  - NCT04578158
AU  - Medical, Liaquat University of
AU  - Sciences, Health
AU  - Bicocca, University of Milano
AU  - Pavia, University of
AU  - Sciences, Dow University of Health
AU  - Oxford, University of
C1  - 10/7/2020
DA  - October 26
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - covid-19
N1  - No Results Available
Drug: Remdesivir|Dietary Supplement: Quercetin Phytosome
Survival time|Length of stay in hospital|Days of mechanical ventilation|Blood parameters according to the protocol described above|Blood gas analysis|Radiological imaging|PaO2|Heart rate|Respiratory rate|Quality of life questionnaire|Number and dose of other drugs used
All
Phase 2
200
Other
Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
LUMHS/REC/894
April 25, 2021
PB  - https://ClinicalTrials.gov/show/NCT04578158
PY  - 2020
ST  - Trial to Study the Adjuvant Benefits of Quercetin Phytosome in Patients With COVID-19
T2  - ClinicalTrials
TI  - Trial to Study the Adjuvant Benefits of Quercetin Phytosome in Patients With COVID-19
UR  - https://ClinicalTrials.gov/show/NCT04578158
ID  - 7794691
ER  - 

TY  - JOUR
AB  - Summary The contribution of CD4+ T cells to protective or pathogenic immune responses to SARS-CoV-2 infection remains unknown Here, we present single-cell transcriptomic analysis of &amp;gt;100,000 viral antigen-reactive CD4+ T cells from 40 COVID-19 patients In hospitalized patients compared to non-hospitalized patients, we found increased proportions of cytotoxic follicular helper (TFH) cells and cytotoxic T helper cells (CD4-CTLs) responding to SARS-CoV-2, and reduced proportion of SARS-CoV-2-reactive regulatory T cells (TREG) Importantly, in hospitalized COVID-19 patients, a strong cytotoxic TFH response was observed early in the illness which correlated negatively with antibody levels to SARS-CoV-2 spike protein Polyfunctional T helper (TH)1 and TH17 cell subsets were underrepresented in the repertoire of SARS-CoV-2-reactive CD4+ T cells compared to influenza-reactive CD4+ T cells Together, our analyses provide insights into the gene expression patterns of SARS-CoV-2-reactive CD4+ T cells in distinct disease severities
AU  - Meckiff, Benjamin J.
AU  - Ram�Trez-Su֙stegui, Ciro
AU  - Fajardo, Vicente
AU  - Chee, Serena J.
AU  - Kusnadi, Anthony
AU  - Simon, Hayley
AU  - Eschweiler, Simon
AU  - Grifoni, Alba
AU  - Pelosi, Emanuela
AU  - Weiskopf, Daniela
AU  - Sette, Alessandro
AU  - Ay, Ferhat
AU  - Seumois, Grégory Ottensmeier
AU  - Christian, H.
AU  - Vijayanand, Pandurangan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
T2  - Cell
TI  - Imbalance of regulatory and cytotoxic SARS-CoV-2-reactive CD4+ T cells in COVID-19
UR  - https://doi.org/10.1016/j.cell.2020.10.001
ID  - 7793213
ER  - 

TY  - JOUR
AD  - Chris O'Brien Lifehouse, Camperdown, New South Wales, Australia.
AN  - 33021868
AU  - McNeil, C. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1200/jco.20.02405
DP  - NLM
ET  - 2020/10/07
J2  - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
LA  - eng
N1  - 1527-7755
McNeil, Catriona M
Journal Article
United States
J Clin Oncol. 2020 Oct 6:JCO2002405. doi: 10.1200/JCO.20.02405.
PY  - 2020
SN  - 0732-183x
SP  - Jco2002405
ST  - Coronavirus Farewell
T2  - Journal of clinical oncology : official journal of American Society of Clinical Oncology
TI  - Coronavirus Farewell
ID  - 7790999
ER  - 

TY  - JOUR
AU  - McFadden, Paula
AU  - Russ, Erics
AU  - Blakeman, Paul
AU  - Kirwin, Gloria
AU  - Anand, Janet
AU  - Lähteinen, Sanna
AU  - Baugerud, Gunn Astrid
AU  - Tham, Pia
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 impact on social work admissions and education in seven international universities
T2  - Social Work Education
TI  - COVID-19 impact on social work admissions and education in seven international universities
UR  - https://doi.org/10.1080/02615479.2020.1829582
ID  - 7792982
ER  - 

TY  - JOUR
AD  - Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Department of Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. nicolas.vabret@mssm.edu.
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. nicolas.vabret@mssm.edu.
AN  - 33024071
AU  - McClain, C. B.
AU  - Vabret, N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41392-020-00335-z
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
McClain, Christopher B
Orcid: 0000-0002-8246-4639
Vabret, Nicolas
Journal Article
England
Signal Transduct Target Ther. 2020 Oct 6;5(1):223. doi: 10.1038/s41392-020-00335-z.
PY  - 2020
SN  - 2059-3635
SP  - 223
ST  - SARS-CoV-2: the many pros of targeting PLpro
T2  - Signal transduction and targeted therapy
TI  - SARS-CoV-2: the many pros of targeting PLpro
VL  - 5
ID  - 7790849
ER  - 

TY  - JOUR
AB  - The purpose of this study was to investigate student satisfaction and perceived clinical reasoning and learning using a computer-based simulation platform that incorporates case-based learning principles The simulation was used to replace a previously scheduled face-to-face clinical rotation which was cancelled due to COVID-19 A descriptive design was used to implement the Satisfaction with Simulation Experience Scale (SSES) with students (n = 27) following each a low fidelity (paper cases) and high fidelity (Simucase&amp;trade;) simulation A comparison of the SSES data following paper cases and simulation scenarios indicated statistically significant increases in Debrief and Reflection (p = 0 008) and Clinical Reasoning (p = 0 043), suggesting that students develop in-depth reflection, reasoning, and clinical abilities as they progress through their simulated experience
AU  - Mattila, Amy
AU  - Martin, Retta M.
AU  - DeIuliis, Elizabeth D.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Simulated Fieldwork: A Virtual Approach to Clinical Education
T2  - Education Sciences
TI  - Simulated Fieldwork: A Virtual Approach to Clinical Education
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813239
ID  - 7793347
ER  - 

TY  - JOUR
AN  - PMC7536544
AU  - Matsuda, Elaine M.
AU  - Santos, Sinvaldo Alves dos
AU  - Castejon, Marcia Jorge
AU  - Ahagon, Cintia Mayumi
AU  - Campos, Ivana Barros de
AU  - Br�Tgido, Lu�Ts Fernando de Macedo
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.bjid.2020.09.002
DP  - NLM
J2  - Braz J Infect Dis
LA  - eng
N1  - PMC7536544[pmcid]
S1413-8670(20)30142-2[PII]
PY  - 2020
SN  - 1413-8670
1678-4391
ST  - COVID-19 in children: a case report of Multisystem Inflammatory Syndrome (MIS-C) in São Paulo, Brazil
T2  - Brazilian Journal of Infectious Diseases
TI  - COVID-19 in children: a case report of Multisystem Inflammatory Syndrome (MIS-C) in São Paulo, Brazil
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536544/
ID  - 7790679
ER  - 

TY  - JOUR
AB  - Summary Background Prominent clinical symptoms of COVID-19 include CNS manifestations However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, gains access to the CNS and whether it causes neuropathological changes We investigated the brain tissue of patients who died from COVID-19 for glial responses, inflammatory changes, and the presence of SARS-CoV-2 in the CNS Methods In this post-mortem case series, we investigated the neuropathological features in the brains of patients who died between March 13 and April 24, 2020, in Hamburg, Germany Inclusion criteria comprised a positive test for SARS-CoV-2 by quantitative RT-PCR (qRT-PCR) and availability of adequate samples We did a neuropathological workup including histological staining and immunohistochemical staining for activated astrocytes, activated microglia, and cytotoxic T lymphocytes in the olfactory bulb, basal ganglia, brainstem, and cerebellum Additionally, we investigated the presence and localisation of SARS-CoV-2 by qRT-PCR and by immunohistochemistry in selected patients and brain regions Findings 43 patients were included in our study Patients died in hospitals, nursing homes, or at home, and were aged between 51 years and 94 years (median 76 years [IQR 70�?6]) We detected fresh territorial ischaemic lesions in six (14%) patients 37 (86%) patients had astrogliosis in all assessed regions Activation of microglia and infiltration by cytotoxic T lymphocytes was most pronounced in the brainstem and cerebellum, and meningeal cytotoxic T lymphocyte infiltration was seen in 34 (79%) patients SARS-CoV-2 could be detected in the brains of 21 (53%) of 40 examined patients, with SARS-CoV-2 viral proteins found in cranial nerves originating from the lower brainstem and in isolated cells of the brainstem The presence of SARS-CoV-2 in the CNS was not associated with the severity of neuropathological changes Interpretation In general, neuropathological changes in patients with COVID-19 seem to be mild, with pronounced neuroinflammatory changes in the brainstem being the most common finding There was no evidence for CNS damage directly caused by SARS-CoV-2 The generalisability of these findings needs to be validated in future studies as the number of cases and availability of clinical data were low and no age-matched and sex-matched controls were included Funding German Research Foundation, Federal State of Hamburg, EU (eRARE), German Center for Infection Research (DZIF)
AU  - Matschke, Jakob
AU  - Lütgehetmann, Marc
AU  - Hagel, Christian
AU  - Sperhake, Jan P.
AU  - Schröder, Ann Sophie
AU  - Edler, Carolin
AU  - Mushumba, Herbert
AU  - Fitzek, Antonia
AU  - Allweiss, Lena
AU  - Dandri, Maura
AU  - Dottermusch, Matthias
AU  - Heinemann, Axel
AU  - Pfefferle, Susanne
AU  - Schwabenland, Marius
AU  - Sumner Magruder, Daniel
AU  - Bonn, Stefan
AU  - Prinz, Marco
AU  - Gerloff, Christian
AU  - Püschel, Klaus
AU  - Krasemann, Susanne
AU  - Aepfelbacher, Martin
AU  - Glatzel, Markus
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
T2  - Lancet Neurology
TI  - Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
UR  - https://doi.org/10.1016/S1474-4422(20)30308-2
ID  - 7793011
ER  - 

TY  - JOUR
AB  - Faced with the COVID-19 pandemic, many countries both in Europe and across the world implemented strict stay-at-home orders. These measures helped to slow the spread of the coronavirus but also led to increased mental and physical health issues for the domestically confined population, including an increase in the occurrence of intimate partner violence (IPV) in many countries. IPV is defined as behavior that inflicts physical, psychological, or sexual harm within an intimate relationship. We believe that as radiologists, we can make a difference by being cognizant of this condition, raising an alert when appropriate and treating suspected victims with care and empathy. The aim of this Special Report is to raise awareness of IPV among radiologists and to suggest strategies by which to identify and support IPV victims. KEY POINTS: �?The COVID-19 pandemic led to a marked increase in the number of intimate partner violence (IPV) cases, potentially leading to increased emergency department visits and radiological examinations. �?Most IPV-related fractures affect the face, fingers, and upper trunk, and may easily be misinterpreted as routine trauma. �?Radiologists should carefully review the medical history of suspicious cases, discuss the suspicion with the referring physician, and proactively engage in a private conversation with the patient, pointing to actionable resources for IPV victims.
AD  - John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA. smatoori@seas.harvard.edu.
Institute of Radiology and Nuclear Medicine and Cancer Center St. Anna Klinik Luzern, Hirslanden Klinik St. Anna, Lucerne, Switzerland. smatoori@seas.harvard.edu.
Department of Radiology, Paracelsus Medical University, Salzburg, Austria. smatoori@seas.harvard.edu.
Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Community Health Intervention and Prevention Programs, Brigham and Women's Hospital, Boston, MA, USA.
Institute of Radiology and Nuclear Medicine and Cancer Center St. Anna Klinik Luzern, Hirslanden Klinik St. Anna, Lucerne, Switzerland.
Clinical Research Group, Klus Apotheke Zurich, Zurich, Switzerland.
Clinic of Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Department of Radiology, Paracelsus Medical University, Salzburg, Austria.
Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR, China.
Department of Radiology, Royal Marsden Hospital, Sutton, UK.
Institute of Radiology and Nuclear Medicine and Cancer Center St. Anna Klinik Luzern, Hirslanden Klinik St. Anna, Lucerne, Switzerland. andreas.gutzeit@hirslanden.ch.
Department of Radiology, Paracelsus Medical University, Salzburg, Austria. andreas.gutzeit@hirslanden.ch.
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland. andreas.gutzeit@hirslanden.ch.
AN  - 33021703
AU  - Matoori, S.
AU  - Khurana, B.
AU  - Balcom, M. C.
AU  - Froehlich, J. M.
AU  - Janssen, S.
AU  - Forstner, R.
AU  - King, A. D.
AU  - Koh, D. M.
AU  - Gutzeit, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00330-020-07332-4
DP  - NLM
ET  - 2020/10/07
J2  - European radiology
KW  - Coronavirus
Domestic violence
Intimate partner violence
Radiology
Wounds and injuries
LA  - eng
N1  - 1432-1084
Matoori, Simon
Orcid: 0000-0002-1559-0950
Khurana, Bharti
Balcom, Marta Chadwick
Froehlich, Johannes M
Janssen, Sonja
Forstner, Rosemarie
King, Ann D
Koh, Dow-Mu
Gutzeit, Andreas
Journal Article
Germany
Eur Radiol. 2020 Oct 6. doi: 10.1007/s00330-020-07332-4.
PY  - 2020
SN  - 0938-7994
ST  - Addressing intimate partner violence during the COVID-19 pandemic and beyond: how radiologists can make a difference
T2  - European radiology
TI  - Addressing intimate partner violence during the COVID-19 pandemic and beyond: how radiologists can make a difference
ID  - 7791012
ER  - 

TY  - JOUR
AB  - In the present work, an extensive QSAR (Quantitative Structure Activity Relationships) analysis of a series of peptide-type SARS-CoV main protease (MPro) inhibitors following the OECD guidelines has been accomplished The analysis was aimed to identify salient and concealed structural features that govern the MPro inhibitory activity of peptide-type compounds The QSAR analysis is based on a dataset of sixty-two peptide-type compounds which resulted in the generation of statistically robust and highly predictive multiple models All the developed models were validated extensively and satisfy the threshold values for many statistical parameters (for e g R2�?�? 80�? 82, Q2loo�?�? 74�? 77, Q2LMO�?�? 66�? 67) The developed QSAR models identified number of sp2 hybridized Oxygen atoms within seven bonds from aromatic Carbon atoms, the presence of Carbon and Nitrogen atoms at a topological distance of 3 and other interrelations of atom pairs as important pharmacophoric features Hence, the present QSAR models have a good balance of Qualitative (Descriptive QSARs) and Quantitative (Predictive QSARs) approaches, therefore useful for future modifications of peptide-type compounds for anti- SARS-CoV activity
AU  - Masand, Vijay H.
AU  - Akasapu, Siddhartha
AU  - Gandhi, Ajaykumar
AU  - Rastija, Vesna
AU  - Patil, Meghshyam K.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Structure features of peptide-type SARS-CoV main protease inhibitors: Quantitative structure activity relationship study
T2  - Chemometrics and Intelligent Laboratory Systems
TI  - Structure features of peptide-type SARS-CoV main protease inhibitors: Quantitative structure activity relationship study
UR  - https://doi.org/10.1016/j.chemolab.2020.104172
ID  - 7793210
ER  - 

TY  - JOUR
AB  - Background /Methods: To examine the status of cardiac rehabilitation programs (CRPs) during COVID-19, a web-based questionnaire was completed by CRP managers from April 23rd-May 14th 2020 Results Overall, 114 representatives of 144 CRPs (79 1% of Canadian programs) responded Of respondents, 41 2% (n=47) reported CRP closure;primary reasons were staff redeployment and facility closure (41% of 51 responses, both) Redeployment occurred in open-CRPs and closed-CRPs (30�u34% and 47�u38% of employees respectively;p= 05) and reduced hours in 17 8�u31% and 22 5�u33% of remaining employees;p= 56 Of open-CRPs, 84 8% accepted referrals for medically high-risk patients pre-COVID-19;falling to only 43 5% during-COVID-19;p80% by phone and/or e-mail Any tele-rehabilitation (one-to-one/group) was also used by 32 7% and 43 5% of CRPs to deliver exercise and education respectively (mostly one-to-one) Resource barriers cited by open- and closed-CRPs were related to technology;no tele-rehabilitation, lack of equipment and patient access (35% of all barriers) while 25 3% of barriers were owing to greater demands on staff time Conclusion Within 2-months of COVID-19 being declared a pandemic, 41 2% of CRPs were closed and almost half of employees redeployed Less time-efficient one-to-one models of remote care mostly by phone/e-mail were adopted Vulnerable populations were disproportionately affected becoming ineligible owing to safety concerns Strategies to open closed-CRPs, admitting high risk/vulnerable populations, and offering group-based tele-rehabilitation should be a national priority Brief Summary An increase in patients with complex cardiac conditions referred to cardiac rehabilitation programs (CRPs) is expected given delayed treatment and cardiac involvement related to COVID-19 Yet, ∼half of employees were redeployed and 41% of Canadian CRPs closed There was a marked decrease in open-CRPs accepting referrals for high medical-risk and vulnerable patients Developing policy that provides strategies to open closed-CRPs, admitting high risk/vulnerable populations, and offering group-based tele-rehabilitation should be a national priority
AU  - Marzolini, Susan
AU  - Ghisi, Gabriela Melo
AU  - Hébert, Andrée-Anne Ahden
AU  - Shobhit, Oh
AU  - Paul
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Cardiac Rehabilitation in Canada during COVID-19
T2  - CJC Open
TI  - Cardiac Rehabilitation in Canada during COVID-19
UR  - https://doi.org/10.1016/j.cjco.2020.09.021
ID  - 7793205
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect animals, however, the whole range of potential hosts is still unknown This work makes an assessment of wildlife susceptibility to SARS-CoV-2 by analyzing the similarities of Angiotensin Converting Enzyme 2 (ACE2) and Transmembrane Protease, Serine 2 (TMPRSS2) —both recognized as receptors and protease for coronavirus spike protein�?and the genetic variation of the viral protein spike in the recognition sites The sequences from different mammals, birds, reptiles, and amphibians, and the sequence from SARS-CoV-2 S protein were obtained from the GenBank Comparisons of aligned sequences were made by selecting amino acids residues of ACE2, TMPRSS2 and S protein;phylogenetic trees were reconstructed using the same sequences The species susceptibility was ranked by substituting the values of amino acid residues for both proteins Our results ranked primates at the top, but surprisingly, just below are carnivores, cetaceans and wild rodents, showing a relatively high potential risk, as opposed to lab rodents that are typically mammals at lower risk Most of the sequences from birds, reptiles and amphibians occupied the lowest ranges in the analyses Models and phylogenetic trees outputs showed the species that are more prone to getting infected with SARS-CoV-2 Interestingly, during this short pandemic period, a high haplotypic variation was observed in the RBD of the viral S protein, suggesting new risks for other hosts Our findings are consistent with other published results reporting laboratory and natural infections in different species Finally, urgent measures of wildlife monitoring are needed regarding SARS-CoV-2, as well as measures for avoiding or limiting human contact with wildlife, and precautionary measures to protect wildlife workers and researchers;monitoring disposal of waste and sewage than can potentially affect the environment, and designing protocols for dealing with the outbreak
AU  - Mart�Tnez-Hern֙ndez, Fernando
AU  - Isaak-Delgado, Ana Belem
AU  - Alfonso-Toledo, Jorge Alberto
AU  - Muñoz-Garc�Ta, Claudia Irais
AU  - Villalobos, Guiehdani
AU  - Aréchiga-Ceballos, Nidia
AU  - Rend�Qn-Franco, Emilio
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Assessing the SARS-CoV-2 threat to wildlife: Potential risk to a broad range of mammals
T2  - Perspectives in Ecology and Conservation
TI  - Assessing the SARS-CoV-2 threat to wildlife: Potential risk to a broad range of mammals
UR  - https://doi.org/10.1016/j.pecon.2020.09.008
ID  - 7793081
ER  - 

TY  - JOUR
AB  - In 5 months of COVID isolation, living out of a suitcase in temporary housing, countless fractal patterns emerged I can?t say if I created these patterns by looking for them, or that I know the whole world by looking at a grain of sand The truth of the matter is that it feels like the key for massive scale change is just in front of us, but slipping from our grasp As we move through these days, weeks, and months, we have very little time before the difference recedes again I address this matter of concern as a matter of method in performative grounded theory piece
AU  - Markham, Annette N.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Pattern Recognition: Using Rocks, Wind, Water, Anxiety, and Doom Scrolling in a Slow Apocalypse (to Learn More About Methods for Changing the World)
T2  - Qualitative Inquiry
TI  - Pattern Recognition: Using Rocks, Wind, Water, Anxiety, and Doom Scrolling in a Slow Apocalypse (to Learn More About Methods for Changing the World)
UR  - https://doi.org/10.1177/1077800420960191
ID  - 7792813
ER  - 

TY  - JOUR
AB  - BACKGROUND: Chronic liver disease (CLD) and cirrhosis are associated with immune dysregulation leading to concerns that these patients may be at risk of adverse outcomes following SARS-CoV-2 infection. However, the impact of COVID-19 among patients with pre-existing liver disease remains ill-defined. METHODS: Data for CLD patients with SARS-CoV-2 were collected by two international registries. Comparisons were made with non-CLD patients with SARS-CoV-2 from a UK hospital network. RESULTS: Between 25th March and 8th July 2020, 745 CLD patients were reported from 29 countries including 386 with cirrhosis and 359 without. Mortality was 32% in patients with cirrhosis compared with 8% in those without (p0.001). Mortality in cirrhosis patients increased according to Child-Turcotte-Pugh class (CTP-A (19%), CTP-B (35%), CTP-C (51%)) and the main cause of death was respiratory failure (71%). After adjusting for baseline characteristics, factors associated with death in the total CLD cohort were age (OR 1.02; 1.01�?.04), CTP-A (OR 1.90; 1.03�?.52), CTP-B (OR 4.14; 2.4�?.65), CTP-C cirrhosis (OR 9.32; 4.80�?8.08) and alcohol related liver disease (ALD) (OR 1.79; 1.03�?.13). When comparing CLD versus non-CLD (n=620) in propensity-score-matched analysis there were significant increases in mortality with CTP-B +20.0% (8.8%�?1.3%) and CTP-C cirrhosis +38.1% (27.1%�?9.2%). Acute hepatic decompensation occurred in 46% of patients with cirrhosis, of which 21% had no respiratory symptoms. 50% of those with hepatic decompensation had acute-on-chronic liver failure. CONCLUSIONS: This is the largest reported cohort of CLD and cirrhosis patients with SARS-CoV-2 infection to date. We demonstrate that baseline liver disease stage and ALD are independent risk factor for death from COVID-19. These data have important implications for the risk stratification of patients with CLD across the globe during the COVID-19 pandemic.
AN  - PMC7536538
AU  - Marjot, Thomas
AU  - Moon, Andrew M.
AU  - Cook, Jonathan A.
AU  - Abd-Elsalam, Sherief
AU  - Aloman, Costica
AU  - Armstrong, Matthew J.
AU  - Pose, Elisa
AU  - Brenner, Erica J.
AU  - Cargill, Tamsin
AU  - Catana, Maria-Andreea
AU  - Dhanasekaran, Renumathy
AU  - Eshraghian, Ahad
AU  - Garc�Ta-Ju֙rez, Ignacio
AU  - Gill, Upkar S.
AU  - Jones, Patricia D.
AU  - Kennedy, James
AU  - Marshall, Aileen
AU  - Matthews, Charmaine
AU  - Mells, George
AU  - Mercer, Carolyn
AU  - Perumalswami, Ponni V.
AU  - Avitabile, Emma
AU  - Qi, Xialong
AU  - Su, Feng
AU  - Ufere, Nneka N.
AU  - Wong, Yu Jun
AU  - Zheng, Ming-Hua
AU  - Barnes, Eleanor
AU  - Barritt, Alfred S. I. V.
AU  - Webb, Gwilym J.
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.jhep.2020.09.024
DP  - NLM
J2  - J Hepatol
KW  - SARS-CoV-2
COVID-19
chronic liver disease
cirrhosis
acute-on-chronic liver failure
LA  - eng
N1  - PMC7536538[pmcid]
S0168-8278(20)33667-9[PII]
PY  - 2020
SN  - 0168-8278
1600-0641
ST  - Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study
T2  - Journal of Hepatology
TI  - Outcomes following SARS-CoV-2 infection in patients with chronic liver disease: an international registry study
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536538/
ID  - 7790675
ER  - 

TY  - JOUR
AU  - Marino, Achille
AU  - Romano, Micol
AU  - Gattinara, Maurizio
AU  - Cimaz, Rolando
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Patients with juvenile idiopathic arthritis on TNF inhibitors exposed to COVID-19 family members
T2  - Seminars in Arthritis and Rheumatism
TI  - Patients with juvenile idiopathic arthritis on TNF inhibitors exposed to COVID-19 family members
UR  - https://doi.org/10.1016/j.semarthrit.2020.09.012
ID  - 7793049
ER  - 

TY  - JOUR
AB  - The current SARS-CoV-2 outbreak leads to a growing need of point-of-care thoracic imaging that is compatible with isolation settings and infection prevention precautions. We retrospectively reviewed 17 COVID-19 patients who received point-of-care lung ultrasound imaging in our isolation unit. Lung ultrasound was able to detect interstitial lung disease effectively; severe cases showed bilaterally distributed B-Lines with or without consolidations; one case showed bilateral pleural plaques. Corresponding to CT scans, interstitial involvement is accurately depicted as B-Lines on lung ultrasound. Lung ultrasound might be suitable for detecting interstitial involvement in a bedside setting under high security isolation precautions.
AD  - Faculty of Medicine, J. W. Goethe University, Theodor-Stern-Kai 7 (H33 C), 60590 Frankfurt am Main, Germany. GRID: grid.7839.5. ISNI: 0000 0004 1936 9721
Department for Infectious Diseases, Centre of Internal Medicine II, University Hospital Frankfurt, Theodor-Stern-Kai 7 (H68-2), 60590 Frankfurt am Main, Germany. GRID: grid.411088.4. ISNI: 0000 0004 0578 8220
Institute of Diagnostic and Interventional Radiology, University Hospital Frankfurt, Theodor-Stern-Kai 7 (H23 C), 60590 Frankfurt am Main, Germany. GRID: grid.411088.4. ISNI: 0000 0004 0578 8220
Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Frankfurt, Theodor-Stern-Kai 7 (H23 C), 60590 Frankfurt am Main, Germany. GRID: grid.411088.4. ISNI: 0000 0004 0578 8220
AN  - 33024935
AU  - Marggrander, D. T.
AU  - Borgans, F.
AU  - Jacobi, V.
AU  - Neb, H.
AU  - Wolf, T.
C1  - 10/7/2020
C2  - PMC7529355
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s42399-020-00553-0
DP  - NLM
ET  - 2020/10/08
J2  - SN comprehensive clinical medicine
KW  - Covid-19
Interstitial pneumonia
Lung ultrasound
SARS-CoV-2
LA  - eng
N1  - 2523-8973
Marggrander, Daniel T
Orcid: 0000-0002-3473-2862
Borgans, Frauke
Jacobi, Volkmar
Neb, Holger
Wolf, Timo
Journal Article
Switzerland
SN Compr Clin Med. 2020 Oct 1:1-7. doi: 10.1007/s42399-020-00553-0.
PY  - 2020
SN  - 2523-8973
SP  - 1-7
ST  - Lung Ultrasound Findings in Patients with COVID-19
T2  - SN comprehensive clinical medicine
TI  - Lung Ultrasound Findings in Patients with COVID-19
ID  - 7790759
ER  - 

TY  - JOUR
AB  - A survey on 5115 beekeepers and 121 patients treated with bee venom by an apitherapy clinic in the Hubei province, the epicenter of COVID-19 in China, reported that none of the beekeepers developed symptoms associated with COVID-19, the new and devastating pandemic. The hypothesis that immunity to bee venom could have a preventive effect was expressed and the authors of the Chinese survey suggested that the next step should be animal experiments on monkeys. We believed that before starting such studies, a second independent survey should verify the findings and define the hypothesis more clearly. Thus we asked all German beekeepers to complete an assessment form which would summarize their experiences with COVID-19. In contrast to the Chinese study we found that two beekeepers had died from a SARS-CoV-2 infection and forty-five were affected. The reaction to bee stings (none; mild swelling; severe swelling) correlated with the perceived severity of the SARS-CoV-2-infection-associated symptoms - exhaustion and sore throat. Beekeepers comorbidity correlated with problems with breathing at rest, fever, and diarrhea. Our results did not confirm the findings of the Chinese study. However, since the antiviral effects of bee venom have been found in several studies, we cannot exclude that there could be a direct preventive or alleviating effect when bee venom is administered during the infection.
AN  - PMC7536547
AU  - Männle, Heidrun
AU  - Hübner, Jutta
AU  - Münstedt, Karsten
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.toxicon.2020.10.004
DP  - NLM
ET  - 2020/10/06
J2  - Toxicon
KW  - COVID-19
Bee venom
Beekeeper
SARS-CoV-2
LA  - eng
N1  - PMC7536547[pmcid]
S0041-0101(20)30408-6[PII]
PY  - 2020
SN  - 0041-0101
1879-3150
SP  - 279-284
ST  - Beekeepers who tolerate bee stings are not protected against SARS-CoV-2 infections
T2  - Toxicon
TI  - Beekeepers who tolerate bee stings are not protected against SARS-CoV-2 infections
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536547/
VL  - 187
ID  - 7790669
ER  - 

TY  - JOUR
AU  - Mandal, Amit K. J.
AU  - Kho, Jason
AU  - Ioannou, Adam
AU  - Van den Abbeele, Koenraad
AU  - Missouris, Constantinos G.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Covid-19 and in situ pulmonary artery thrombosis
T2  - Respiratory Medicine
TI  - Covid-19 and in situ pulmonary artery thrombosis
UR  - https://doi.org/10.1016/j.rmed.2020.106176
ID  - 7793060
ER  - 

TY  - JOUR
AU  - Mamun, Mohammed
AU  - Sakib, Najmuj
AU  - Gozal, David
AU  - Bhuiyan, A. K. M. Israfil
AU  - Hossain, Sahadat
AU  - Bodrud-Doza, Md
AU  - Al Mamun, Firoj
AU  - Hosen, Ismail
AU  - Abdullah, Abu Hasnat
AU  - Sarker, Md Abedin
AU  - Rayhan, Istiak
AU  - Sikder, Md Tajuddin
AU  - Muhit, Mohammad
AU  - Lin, Chung-Ying
AU  - Griffiths, Mark D.
AU  - Pakpour, Amir H.
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - COVID-19
Depression
Suicidal ideation
Psychological impact
Bangladeshi people
PY  - 2020
ST  - The Psychological Consequences of COVID-19 Pandemic Lockdown in Bangladesh: A Population-Based Study (preprint)
T2  - SSRN
TI  - The Psychological Consequences of COVID-19 Pandemic Lockdown in Bangladesh: A Population-Based Study (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3674077
ID  - 7794799
ER  - 

TY  - JOUR
AB  - As COVID 19 continues to spread throughout the United States, there has been a search for policies to both prevent individual infections, to slow the spread of the virus in general, and to mitigate the economic impact of the pandemic. Masks have proven to be a cost-effective measure in all regards, and as such some state governments have begun to mandate their use. However, while the efficacy of masks has been demonstrated, the efficacy of public policies which mandate the use of masks has not been demonstrated. This paper compares the rates of mask use in counties as defined by state policy. It is found that state mandates are strongly correlated with higher rates of mask use, and that mandating use by all individuals in public spaces is more effective than a less comprehensive mandate for mask use by all public facing employees.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNoneAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Publicly available open source data: https://github.com/nytimes/covid-19-data/blob/master/LICENSE https://github.com/USCOVIDpolicy/COVID-19-US-State-Policy-DatabaseAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesRe-analysis of previously reported survey in light of state mask policies.https://github.com/nytimes/covid-19-data/blob/master/mask-use/README.mdhttps://docs.google.com/spreadsheets/d/1zu9qEWI8PsOI_i8nI_S29HDGHlIp2lfVMsGxpQ5tvAQ/edit#gid=973655443
AU  - Maloney, Michael J.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206326
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206326
ST  - Comparative policy analysis of face mask mandates during COVID 19 pandemic on rate of mask use in the United States (preprint)
T2  - medRxiv
TI  - Comparative policy analysis of face mask mandates during COVID 19 pandemic on rate of mask use in the United States (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206326.abstract
ID  - 7794757
ER  - 

TY  - JOUR
AU  - Malekoff, Andrew
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - From the editor: pandemic stories from India
T2  - Social Work with Groups
TI  - From the editor: pandemic stories from India
UR  - https://doi.org/10.1080/01609513.2021.1829856
ID  - 7792684
ER  - 

TY  - JOUR
AB  - Covid-19 first occurred in Wuhan, China in December 2019. Subsequently, the virus spread throughout the world and as of June 2020 the total number of confirmed cases are above 4.7 million with over 315,000 deaths. Machine learning algorithms built on radiography images can be used as a decision support mechanism to aid radiologists to speed up the diagnostic process. The aim of this work is to conduct a critical analysis to investigate the applicability of convolutional neural networks (CNNs) for the purpose of COVID-19 detection in chest X-ray images and highlight the issues of using CNN directly on the whole image. To accomplish this task, we use 12-off-the-shelf CNN architectures in transfer learning mode on 3 publicly available chest X-ray databases together with proposing a shallow CNN architecture in which we train it from scratch. Chest X-ray images are fed into CNN models without any preprocessing to replicate researches used chest X-rays in this manner. Then a qualitative investigation performed to inspect the decisions made by CNNs using a technique known as class activation maps (CAM). Using CAMs, one can map the activations contributed to the decision of CNNs back to the original image to visualize the most discriminating region(s) on the input image. We conclude that CNN decisions should not be taken into consideration, despite their high classification accuracy, until clinicians can visually inspect and approve the region(s) of the input image used by CNNs that lead to its prediction.
AD  - Department of Computer Science and Information Technology, College of Science, Salahaddin University, Erbil, Kurdistan Region, Iraq.
Department of Software Engineering, Faculty of Engineering, Koya University, Koya KOY45, Kurdistan Region, Iraq.
Independent Researcher, Toronto, ON, Canada.
Oxford Drug Design, Oxford Centre for Innovation, New Road, Oxford, OX1 1BY, UK. aras.asaad@oxforddrugdesign.com.
AN  - 33025386
AU  - Majeed, T.
AU  - Rashid, R.
AU  - Ali, D.
AU  - Asaad, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s13246-020-00934-8
DP  - NLM
ET  - 2020/10/08
J2  - Physical and engineering sciences in medicine
KW  - Covid-19
Class activation maps
Convolutional neural network
Coronavirus
Deep learning
LA  - eng
N1  - 2662-4737
Majeed, Taban
Rashid, Rasber
Ali, Dashti
Asaad, Aras
Orcid: 0000-0001-9578-8838
Journal Article
Switzerland
Phys Eng Sci Med. 2020 Oct 6. doi: 10.1007/s13246-020-00934-8.
PY  - 2020
SN  - 2662-4729
ST  - Issues associated with deploying CNN transfer learning to detect COVID-19 from chest X-rays
T2  - Physical and engineering sciences in medicine
TI  - Issues associated with deploying CNN transfer learning to detect COVID-19 from chest X-rays
ID  - 7790709
ER  - 

TY  - JOUR
AB  - Background: Quantifying antibody reactivity to SARS-CoV-2 antigens may help understand its effect on COVID-19 severity at the population level. This antibody reactivity may be particularly prevalent among childcare providers, including pediatric health care workers (HCW) who may be more exposed to circulating coronaviruses. Methods: Cross-sectional study that included adults in the Vancouver area in British Columbia (BC), Canada, between May 17 and June 19, 2020. A novel 10-plex antibody assay (IgG) was used to measure antibody reactivity against the spike protein from circulating coronaviruses (229E, NL63, OC43, and HKU1), SARS-CoV, and four SARS-CoV-2 antigens. Seroreactivity from previous viral exposure was ascertained using this assay, and by measuring total SARS-CoV-2 IgG/M/A antibodies against a recombinant spike (S1) protein using a commercial CLIA assay. Findings: Among 276 participants (71% HCW), three showed evidence of direct viral exposure, yielding an adjusted seroprevalence of 0.6% [95%CI 0.2 to 3.1%], with no difference between HCW and non-HCW, or between paediatric and adult HCW. Among the remaining 273 unexposed individuals, 7.3% [95%CI 4.5% to 11.1%], 48.7 [95%CI 42.7% to 54.8%] and 82.4% [95%CI 77.4% to 86.7%] showed antibody reactivity against SARS-CoV-2 RBD, N or Spike proteins, respectively. This reactivity was evenly distributed as a function of age, sex or between paediatric and adult HCW, and partly correlated with reactivity to circulating coronaviruses (Spearman; range: 0.147 to 0.513 for significant correlation after false-discovery rate adjustment at 5%). Interpretation: A substantial proportion of individuals in this population showed antibody reactivity against SARS-CoV-2 antigens despite low serological evidence of SARS-CoV-2 exposure.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialThis study is not a clinical trialFunding StatementThis study was supported by unrestricted grant funding to PML and an Intramural Research Program of the Vaccine Research Centre (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH). The funders did not play a role in the design, planning, execution, analysis or publication of the study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was approved by the University of British Columbia Children&#039;s &amp;amp; Women&#039;s Research Ethic Board (H20-01205).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesNon-identifying metadata will be provided (in process); participant specific demographic data may be made available later, or to external investigators upon request, if can be agreed by participants and after obtaining permissions from relevant institutional ethics review boards...
AU  - Majdoubi, Abdelilah
AU  - Oconnell, Sarah E.
AU  - Michalski, Christina
AU  - Dada, Sarah
AU  - Narparla, Sandeep
AU  - Gelinas, Jean
AU  - Mehta, Disha
AU  - Cheung, Claire
AU  - Basappa, Manjula
AU  - Gorges, Matthias
AU  - Barakauska, Vilte E.
AU  - Goldfarb, David M.
AU  - Douek, Daniel
AU  - McDermott, Adrian B.
AU  - Lavoie, Pascal
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206664
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206664
ST  - Antibody reactivity to SARS-CoV-2 in adults from the Vancouver metropolitan area, Canada (preprint)
T2  - medRxiv
TI  - Antibody reactivity to SARS-CoV-2 in adults from the Vancouver metropolitan area, Canada (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.05.20206664.abstract
ID  - 7794705
ER  - 

TY  - JOUR
AD  - The BMJ.
AN  - 33023893
AU  - Mahase, E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/bmj.m3891
DP  - NLM
ET  - 2020/10/08
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Mahase, Elisabeth
Journal Article
England
BMJ. 2020 Oct 6;371:m3891. doi: 10.1136/bmj.m3891.
PY  - 2020
SN  - 0959-8138
SP  - m3891
ST  - Covid-19: Only half of 16�?00 patients missed from England's official figures have been contacted
T2  - BMJ
TI  - Covid-19: Only half of 16�?00 patients missed from England's official figures have been contacted
VL  - 371
ID  - 7790867
ER  - 

TY  - JOUR
AB  - The researchers said their findings “may be particularly relevant during the covid-19 pandemic, as patients and clinicians weigh the benefits and risks of each approach, considering individual characteristics, preferences, and circumstances.�?In guidance for the triage of emergency general surgery patients during the pandemic, published in March,2 the American College of Surgeons said antibiotics could be considered for uncomplicated appendicitis, “based on the surgeon’s judgment and the patient’s condition.�?The authors listed a number of limitations of the study, including that, as only 90 day follow-up data was included, the study “underrepresents recurrence and long term complications.�?
AN  - 2448515366
AU  - Mahase, Elisabeth
C1  - 10/7/2020
DA  - 2020 Oct 05
2020-10-06
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1136/bmj.m3870
DP  - ProQuest Central
KW  - Medical Sciences
Patients
Appendicitis
Surgery
Antibiotics
Pandemics
Medical research
COVID-19
Coronaviruses
Appendectomy
LA  - English
N1  - Name - American College of Surgeons
Copyright - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go tohttp://group.bmj.com/group/rights-licensing/permissions2020BMJ
PY  - 2020
ST  - Antibiotics are as good as surgery for appendicitis, study reports
T2  - BMJ
TI  - Antibiotics are as good as surgery for appendicitis, study reports
UR  - https://www.proquest.com/docview/2448515366?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Asciencejournals&atitle=Antibiotics+are+as+good+as+surgery+for+appendicitis%2C+study+reports&title=BMJ+%3A+British+Medical+Journal+%28Online%29&issn=&date=2020-10-05&volume=371&issue=&spage=&au=Mahase%2C+Elisabeth&isbn=&jtitle=BMJ+%3A+British+Medical+Journal+%28Online%29&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1136%2Fbmj.m3870
VL  - 371
ID  - 7789882
ER  - 

TY  - JOUR
AB  - INTRODUCTION: COVID-19 has been declared a pandemic by the World Health Organization (WHO). Many of the COVID-19 patients develop acute respiratory distress syndrome (ARDS) and require ventilatory support based on their severity for which conventional strategies are being used along with few newer strategies. We conducted this multicenter survey to know the physician's current ventilation strategies adopted for the care of COVID-19 patients. MATERIALS AND METHODS: The survey was conducted after taking the ethical committee clearance. The web-based multicenter, cross-sectional questionnaire study was sent to physicians, who were involved in the management of COVID-19 patients. The questionnaire was segregated into three parts: part one consisted of general information and consent form, part two was concerned regarding demographic characteristics, and part three was concerned about their practices and strategies for ventilation of COVID-19 patients. RESULTS: A total of 223 responders replied for the questionnaire; 190 participated in the study saying that they are involved in the management of COVID-19 patients. The answers to the questionnaires were expressed as a percentage of total responses. 86% of the respondents said they have a designated intensive care unit (ICU) and 89% of the responders said they have an intubation/extubation protocol for suspect/confirmed COVID-19 patients. The responses of junior residents (JRs), senior residents (SRs), assistant professors/junior consultants, and professors/consultants were analyzed separately, and a few significant differences were observed. 39% of JRs were aware of prone ventilation as the most effective rescue ventilation strategy compared to 69% of consultants/professors. Extracorporeal membranous oxygenation (ECMO) strategy was also more significant in consultants/professors (40%) vs JRs (12%). The responders were also diverged based on medical college and corporate hospitals, and their responses were noted. Most commonly, responders in the corporate hospitals had a facility to ventilate COVID-19 patients in a negative pressure isolation facility compared to a nonnegative pressure room isolation facility in medical colleges. CONCLUSION: Most of the responders were practicing ventilation strategies in a standard manner. JRs need to undergo further training in a few aspects of the ventilatory management, and also, they need to update themselves with newer treatment modalities as they keep evolving. Medical colleges are providing at par facility compared to corporate hospitals except for few advance care facilities. CLINICAL SIGNIFICANCE: This study highlights the current practice of ventilatory management of COVID-19 patients, which is satisfactory. The survey can be used to develop study tools, to educate resident doctors, to further improve quality of care of critical COVID-19 patients. HOW TO CITE THIS ARTICLE: Maddani SS, Deepa HC, Rao S, Chaudhuri S. A Multicenter Cross-sectional Questionnaire-based Study to know the Practices and Strategies of Ventilatory Management of COVID-19 Patients among the Treating Physicians. Indian J Crit Care Med 2020;24(8):643-648.
AD  - Department of Critical Care Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.
AN  - 33024368
AU  - Maddani, S. S.
AU  - Deepa, H. C.
AU  - Rao, S.
AU  - Chaudhuri, S.
C1  - 10/7/2020
C2  - PMC7519590
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23516
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Covid-19
Endotracheal intubation
Intensive care unit
Ventilation management
LA  - eng
N1  - Maddani, Sagar S
Deepa, Hunasaghatta Chandrappa
Rao, Shwethapriya
Chaudhuri, Souvik
Journal Article
India
Indian J Crit Care Med. 2020 Aug;24(8):643-648. doi: 10.5005/jp-journals-10071-23516.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 643-648
ST  - A Multicenter Cross-sectional Questionnaire-based Study to Know the Practices and Strategies of Ventilatory Management of COVID-19 Patients among the Treating Physicians
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - A Multicenter Cross-sectional Questionnaire-based Study to Know the Practices and Strategies of Ventilatory Management of COVID-19 Patients among the Treating Physicians
VL  - 24
ID  - 7790808
ER  - 

TY  - JOUR
AB  - The global coronavirus disease 2019 (COVID-19) will exacerbate the negative health outcomes associated with the concurrent opioid overdose crisis in North America COVID-19 brings unique challenges for practitioners who provide opioid use disorder (OUD) care The majority of overdose deaths in the Canadian province of British Columbia occur in housing environments Some supportive housing environments in Vancouver, British Columbia, have on-site primary care and substance use disorder treatment clinics Some of these housing environments also include supervised consumption services These housing environments needed to make adjustments to their care to adhere to COVID-19 physical distancing measures Such adjustments included a pandemic withdrawal management program to provide patients with a pharmaceutical grade alternative to the toxic illicit drug supply, which allow patients to avoid the heightened overdose risk while using illicit drugs alone or potentially exposing themselves to COVID-19 while using drugs in a group setting Other modifications to the OUD care continuum included modified supervised injection spaces to adhere to physical distancing, the use of personal protective equipment for overdose response, virtual platforms for clinical encounters, writing longer prescriptions, and providing take-home doses to promote opioid agonist treatment retention These strategies aim to mitigate indoor overdose risk while also addressing COVID-19 risks
AU  - MacKinnon, Laura
AU  - Soc�Tas, M. Eugenia
AU  - Bardwell, Geoff
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 and overdose prevention: Challenges and opportunities for clinical practice in housing settings
T2  - Journal of Substance Abuse Treatment
TI  - COVID-19 and overdose prevention: Challenges and opportunities for clinical practice in housing settings
UR  - https://doi.org/10.1016/j.jsat.2020.108153
ID  - 7793115
ER  - 

TY  - JOUR
AB  - What is already known about this topic?

Community mitigation measures can help slow the spread of COVID-19.

What is added by this report?

The number of COVID-19 cases in Arizona stabilized and then decreased after sustained implementation and enforcement of statewide and locally enhanced mitigation measures, beginning approximately 2 weeks after implementation and enforcement of mask mandates and enhanced sanitations practices began on June 17; further decreases were observed during July 13–August 7, after statewide limitations and closures of certain services and businesses.

What are the implications for public health practice?

Widespread implementation and enforcement of sustained community mitigation measures, including mask wearing, informed by state and local officials�?continual data monitoring and collaboration can help prevent transmission of SARS-CoV-2 and decrease the numbers of COVID-19 cases.
AU  - M. Shayne Gallaway, PhD1, 2; Jessica Rigler, MPH1; Susan Robinson, MPH1; Kristen Herrick, MPH1; Eugene Livar, MD1; Kenneth K. Komatsu, MPH1; Shane Brady, MPH1; Jennifer Cunico1; Cara M. Christ, MD
C1  - 10/7/2020
DB  - Centers for Disease Control and Prevention
DP  - Centers for Disease Control and Prevention
IS  - early release
PY  - 2020
ST  - Trends in COVID-19 Incidence After Implementation of Mitigation Measures �?Arizona, January 22–August 7, 2020
T2  - MMWR Morbidity and Mortality Weekly Report
TI  - Trends in COVID-19 Incidence After Implementation of Mitigation Measures �?Arizona, January 22–August 7, 2020
UR  - http://www.cy118119.com/mmwr/volumes/69/wr/mm6940e3.htm?s_cid=mm6940e3_w
VL  - 69
ID  - 7794690
ER  - 

TY  - JOUR
AB  - Objectives: To develop a novel multiple cross displacement amplification (MCDA) assay for COVID-19 and compare its speed and sensitivity to existing loop-mediated isothermal amplification (LAMP) and real-time PCR (RT-PCR) methods. Methods: Two MCDA assays targeting the SARS-CoV-2 N gene and ORF1ab was designed. The fastest time to detection and sensitivity of MCDA was compared to LAMP and RT-PCR using 7 DNA standards and transcribed RNA. Results: For the N gene, MCDA was consistently faster than LAMP and RT-PCR by 10 and 20 minutes, respectively with a fastest time to detection of 5.2 minutes. RT-PCR had the highest sensitivity with a limit of detection of 100 copies/reaction compared with MCDA (1000 copies/reaction) and LAMP (5000/reaction). For ORF1ab, MCDA and LAMP had similar speed with fastest time to detection at 9.7 and 8.4 minutes, respectively. LAMP was more sensitive for ORF1ab detection with 500 copies/reaction compared to MCDA (5000 copies/reaction). Conclusions: Different nucleic acid amplification methods provide different advantages. MCDA is the fastest nucleic acid amplification method for COVID-19 while RT-PCR is still the most sensitive. These advantages should be considered when determining the most suitable nucleic acid amplification methods for different applications.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by a UNSW school research grant.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This research does not include clinical samples therefore no oversight approval was required.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data is provided in the manuscript and/or in the supplementary materials.
AU  - Luu, Laurence Don Wai
AU  - Payne, Michael J.
AU  - Zhang, Xiaomei
AU  - Luo, Lijuan
AU  - Lan, Ruiting
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206193
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206193
ST  - Development and comparison of a novel multiple cross displacement amplification (MCDA) assay with other nucleic acid amplification methods for SARS-CoV-2 detection (preprint)
T2  - medRxiv
TI  - Development and comparison of a novel multiple cross displacement amplification (MCDA) assay with other nucleic acid amplification methods for SARS-CoV-2 detection (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206193.abstract
ID  - 7794756
ER  - 

TY  - JOUR
AB  - The SARS-CoV-2 nucleocapsid (N) protein is the most immunogenic of the structural proteins and plays essential roles in several stages of the virus lifecycle. It is comprised of two major structural domains: the RNA binding domain, which interacts with viral and host RNA, and the oligomerization domain which assembles to form the viral core. Here, we investigate the assembly state and RNA binding properties of the full-length nucleocapsid protein using native mass spectrometry. We find that dimers, and not monomers, of full-length N protein bind RNA, implying that dimers are the functional unit of ribonucleoprotein assembly. In addition, we find that N protein binds RNA with a preference for GGG motifs which are known to form short stem loop structures. Unexpectedly, we found that N undergoes autoproteolytic processing within the linker region, separating the two major domains. This process results in the formation of at least five proteoforms that we sequenced using electron transfer dissociation, higher-energy collision induced dissociation and corroborated by peptide mapping. The cleavage sites identified are in highly conserved regions leading us to consider the potential roles of the resulting proteoforms. We found that monomers of N-terminal proteoforms bind RNA with the same preference for GGG motifs and that the oligomeric state of a C-terminal proteoform (N156-419) is sensitive to pH. We used mass spectrometry to show that N binds to a monoclonal antibody raised against full-length N. No antibody interactions were detected for N proteoforms without C-terminal residues, therefore locating antigenic regions towards the C-terminus. We then tested interactions of the proteoforms with the immunophilin cyclophilin A, a key component in coronavirus replication. We found that N1-209 and N1-273 bind directly to cyclophilin A, an interaction that is abolished by the approved immunosuppressant drug cyclosporin A. We propose that the proteoforms generated via autoproteolysis evade antibody detection through removal of the antigenic C-terminus and facilitate interactions with structured RNA or cyclophilin thereby enabling the virus to proliferate.Competing Interest StatementThe authors have declared no competing interest.
AU  - Lutomski, Corinne A.
AU  - El-Baba, Tarick J.
AU  - Bolla, Jani R.
AU  - Robinson, Carol V.
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.328112
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.328112
ST  - Autoproteolytic Products of the SARS-CoV-2 Nucleocapsid Protein are Primed for Antibody Evasion and Virus Proliferation (preprint)
T2  - bioRxiv
TI  - Autoproteolytic Products of the SARS-CoV-2 Nucleocapsid Protein are Primed for Antibody Evasion and Virus Proliferation (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.328112.abstract
ID  - 7794722
ER  - 

TY  - JOUR
AB  - Background: The World Health Organization has identified contact tracing and isolation (CTI) as a key strategy to slow transmission of SARS-CoV-2. Structured agent-based models (ABMs) provide a means to investigate the efficacy of such strategies in heterogeneous populations and to explore the impact of factors such as changes in test turnaround times (TaT). Methods: We developed a structured ABM to simulate key SARS-CoV-2 transmission and Covid-19 disease progression dynamics in populations of 10,000 agents. We ran 10,000 simulations of each of three scenarios: (1) No CTI with a TaT of two days, (2) CTI with a TaT of two days, and (3) CTI with a TaT of eight days. We conducted a secondary analysis in which TaT values were varied from two to 11. The primary outcome for all analyses was mean total infections. Results: CTI reduced the mean number of infections from 5,577 to 4,157 (a relative reduction of 25.5%) when TaT was held steady at two days. CTI with a TaT of eight days resulted in a mean of 5,163 infections (a relative reduction of 7.4% compared to no CTI and a TaT of two days). In the secondary analysis, every additional day added to the TaT increased the total number of infections - with the greatest increase in infections between four and five days, and the smallest increase between ten and eleven days. Conclusions: In a structured ABM that simulates key dynamics of Covid-19 transmission and disease progression, CTI results in a substantial reduction in the mean number of total infections. The benefit is greater with shorter TaT times, but remained substantial even with TaTs of eight days. The results suggest that CTI may play a critical role in reducing the size of outbreaks and that TaTs should be kept as short as possible in order to maximise this benefit.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding received.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NAAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll code and data are available on GitHub.
AU  - Low, Marcus O.
AU  - Geffen, Nathan
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.06.20207761
DP  - medRxiv
PY  - 2020
SP  - 2020.10.06.20207761
ST  - Contact tracing and isolation reduces Covid-19 incidence in a structured agent-based model (preprint)
T2  - medRxiv
TI  - Contact tracing and isolation reduces Covid-19 incidence in a structured agent-based model (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.06.20207761.abstract
ID  - 7794712
ER  - 

TY  - JOUR
AB  - Health disparity refers to systematic differences in health outcomes between groups and communities based on socioeconomic isolation. In the USA, health disparities among minority groups, especially African Americans, limit their access to quality medical care and other beneficial resources and services. Presently, the novel coronavirus (COVID-19) highlights the extreme healthcare challenges that exist in the African American and other minority communities in the USA. African Americans are dying at a rate nearly four times higher than the national average. With inadequate access to quality healthcare, viable resources, and information, COVID-19 will continue to have a disastrous effect on African American communities. This communication provides a brief overview of the health inequalities resulting in African Americans dying disproportionately during the COVID-19 pandemic.
AD  - University of Nevada Las Vegas, Las Vegas, NV, USA. louisjea@unlv.nevada.edu.
Homestead Middle School, Homestead, FL, USA.
Nevada Division of Public and Behavioral Health, Carson City, NV, USA.
Florida International University, Miami, FL, USA.
Florida State University, Tallahassee, FL, USA.
AN  - 33025419
AU  - Louis-Jean, J.
AU  - Cenat, K.
AU  - Njoku, C. V.
AU  - Angelo, J.
AU  - Sanon, D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s40615-020-00879-4
DP  - NLM
ET  - 2020/10/08
J2  - Journal of racial and ethnic health disparities
KW  - African American
Coronavirus
Health disparity
Socioeconomic
LA  - eng
N1  - 2196-8837
Louis-Jean, James
Orcid: 0000-0002-7711-0967
Cenat, Kenney
Njoku, Chidinma V
Angelo, James
Sanon, Debbie
Journal Article
Switzerland
J Racial Ethn Health Disparities. 2020 Oct 6. doi: 10.1007/s40615-020-00879-4.
PY  - 2020
SN  - 2196-8837
ST  - Coronavirus (COVID-19) and Racial Disparities: a Perspective Analysis
T2  - Journal of racial and ethnic health disparities
TI  - Coronavirus (COVID-19) and Racial Disparities: a Perspective Analysis
ID  - 7790708
ER  - 

TY  - JOUR
AB  - Spirituality has been a part of nursing for many centuries and represents an essential value for people, including nurses and patients Cumulative evidence points to the positive contribution of spiritually on health and wellbeing However, there is little clarity about what spirituality means The literature reveals that nurses have ascribed a diversity of interpretations to spirituality However, no studies have investigated how registered nurses construct their understanding of spirituality using a critical discourse analysis approach Therefore, the aim of this study was to uncover how registered nurses construct their understanding of spirituality using a critical discourse analysis approach Twenty registered nurses from a non-denominational public hospital and a faith-based private hospital were interviewed about their understanding of spirituality and practice of spiritual care A critical discourse analysis approach was used in the examination of the interview texts to uncover underlying social and power features Links were made between the linguistic features the registered nurses used in their interviews and the broader social context of the study Three discourses emerged from the interview texts These include constructing spirituality through personal religious beliefs discourse, holistic discourse and empathetic care discourse The findings of this study have implications for nurse education and policy makers
AU  - Louise Cooper, Katherine
AU  - Luck, Lauretta
AU  - Chang, Esther
AU  - Dixon, Kathleen
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - What is the practice of spiritual care? A critical discourse analysis of registered nurses�?understanding of spirituality
T2  - Nursing Inquiry
TI  - What is the practice of spiritual care? A critical discourse analysis of registered nurses�?understanding of spirituality
UR  - https://doi.org/10.1111/nin.12385
ID  - 7792869
ER  - 

TY  - GEN
AB  - The evaluated SARS-CoV-2 antigen rapid fluorescence immunoassays reliably identified patients within the first 5 days of symptom onset, when respiratory secretions carried high viral loads. This high performance suggests that these tests might play an important role for future PCR-independent strategies to detect early or infective cases.
AU  - Lorena, Porte
AU  - Paulette, Legarraga
AU  - Mirentxu, Iruretagoyena
AU  - Valeska, Vollrath
AU  - Gabriel, Pizarro
AU  - JosÃ© Manuel, Munita
AU  - Rafael, Araos
AU  - Thomas, Weitzel
C1  - 10/7/2020
DB  - PREPRINT-MEDRXIV
DO  - 10.1101/2020.10.04.20206466
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
ST  - Rapid SARS-CoV-2 antigen detection by immunofluorescence - a new tool to detect infectivity
TI  - Rapid SARS-CoV-2 antigen detection by immunofluorescence - a new tool to detect infectivity
UR  - https://medrxiv.org/cgi/content/short/2020.10.04.20206466
ID  - 7793401
ER  - 

TY  - JOUR
AB  - Background: Surveillance of COVID infection and isolation of infected individuals is one of the available tools to control the spread of SAR-CoV-2. Asymptomatic and pre symptomatic are responsible for substantial transmission. RNA or antigen tests are necessary to identify non-symptomatic individuals. We tested the feasibility of using samples pooling offering different collection alternatives (swab/throat wash/saliva) to volunteers of a public health institute. Methods: We evaluated pool samples from both reconstituted (frozen material from tested samples) and a prospective collection of asymptomatic volunteers. Some collections were paired for comparison. Pooled and some individual samples were extracted with QIAamp Viral RNA Mini Kit (Qiagen, USA) and/or Lucigen Quick Extract DNA extraction solution (BioSearch, USA) and submitted to rtCCR using (Allplex, Seegene, Korea). Results: A total of 240 samples from 130 new collections and 37 samples with known result were evaluated. Pool CT was generally higher than individual samples. Lucigen extraction showed higher CT, including false negative results for samples with high CT at Qiagen extraction. Paired Swab and TW samples showed comparable results. No volunteer from negative pools reported any symptom in the 2-3 days after collection. Conclusions: Clinical samples pooling to detect SARS-CoV-2 RNA is feasible and an economical way to test for COVID-19, especially in surveillance strategies targeting more infectiousness, higher viremia individuals. The use of Lucigen reagents show lower sensibility that may lead to false negative results with lower viremia samples. Combining throat wash with saliva may provide and interesting alternative for auto collection, but more comparative work is needed.Competing Interest StatementThe authors have declared no competing interest.Clinical Trialthe study is part of a surveillance initiative to provide test to health care workers and it is ot a clinical trialFunding StatementThe project was mostly supported by institutional funds.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:approved by the institutional ethical committe CEPIAL CAAE 31924420.8.0000.0059All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data presented is available for consultation
AU  - Lopes, Giselle Ibette Silva Lopez
AU  - Carmona, Rita de Cassia Compagnoli
AU  - Silva, Valeria Oliveira
AU  - Ahagon, Cintia Mayumi
AU  - do Prado, Lincoln Spinazola
AU  - dos Santos, Fabiana Cristina Pereira
AU  - da Silva, Daniela Bernardes Borges
AU  - Ribeiro, Wiliam Nery
AU  - Matshuda, Elaine Monteiro
AU  - Cilli, Auldrey
AU  - Afonso, Ana Maria Sardinha
AU  - Pinho, Margarete Aparecida Benaga
AU  - Timnetsky, Maria do Carmo Sampaio Tavare
AU  - Brigido, Luis Fernando de Macedo
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20205872
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20205872
ST  - SARS-CoV-2 RNA detection using pooling of self-collected samples: Simple protocols may foster asymptomatic surveillance (preprint)
T2  - medRxiv
TI  - SARS-CoV-2 RNA detection using pooling of self-collected samples: Simple protocols may foster asymptomatic surveillance (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.05.20205872.abstract
ID  - 7794706
ER  - 

TY  - JOUR
AB  - Abstract Objective Severe COVID-19 has been anecdotally associated with high insulin requirements. It has been proposed that this may be driven by a direct diabetogenic effect of the virus that is unique to SARS-CoV-2, but evidence to support this is limited. To explore this, we compared insulin requirements in patients with severe COVID-19 and non-COVID-19 viral pneumonitis. Research Design Retrospective cohort study of patients with severe COVID-19 admitted to our intensive care unit between March and June 2020. A historical control cohort of non-COVID-19 viral pneumonitis patients was identified from routinely collected audit data. Results Insulin requirements were similar in patients with COVID-19 and non-COVID-19 viral pneumonitis after adjustment for pre-existing diabetes and severity of respiratory failure. Conclusions In this single center study, we could not find evidence of a unique diabetogenic effect of COVID-19. We suggest that high insulin requirements in this disease relate to its propensity to cause severe respiratory failure in patients with pre-existing metabolic disease.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNot registered as study was a retrospective analysis of routinely collected dataFunding StatementSL is supported by a National Institute of Health Research Academic Clinical Fellowship. ACM is supported by a Clinical Research Career Development Fellowship from the Wellcome Trust (WT 2055214/Z/16/Z)Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:As a retrospective analysis of anonymized, routinely collected data the requirement for ethical committee review and consent was waived by the National Health Service Health Research Authority, the evaluation was registered with the responsible healthcare organization (Cambridge University Hospitals NHS Foundation Trust). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesFully anonymised data is available on request to the corresponding author.
AU  - Lockhart, Sam
AU  - Griffiths, Harry
AU  - Petrisor, Bogdan
AU  - Usman, Ammara
AU  - Calvo-Latorre, Julia
AU  - Heales, Laura
AU  - Bansiya, Vishakha
AU  - Mahroof, Razeen
AU  - Conway Morris, Andrew
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206284
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206284
ST  - The excess insulin requirement in severe COVID-19 compared to non-COVID-19 viral pneumonitis is related to the severity of respiratory failure and pre-existing diabetes (preprint)
T2  - medRxiv
TI  - The excess insulin requirement in severe COVID-19 compared to non-COVID-19 viral pneumonitis is related to the severity of respiratory failure and pre-existing diabetes (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206284.abstract
ID  - 7794747
ER  - 

TY  - JOUR
AD  - Sociedad Española de Anestesiolog�Ta-Reanimaci�Qn y Terapéutica del Dolor (SEDAR), España; Hospital Universitari Doctor Peset, Valencia, España. Electronic address: juanvllau@gmail.com.
Sociedad Española de Anestesiolog�Ta-Reanimaci�Qn y Terapéutica del Dolor (SEDAR), España; Hospital Universitari i Polit؈cnic La Fe, Valencia, España.
Sociedad Española de Anestesiolog�Ta-Reanimaci�Qn y Terapéutica del Dolor (SEDAR), España; Fundaci�Q Puigver, Barcelona, España.
Sociedad Española de Anestesiolog�Ta-Reanimaci�Qn y Terapéutica del Dolor (SEDAR), España; Cl�Tnica Universidad de Navarra, Pamplona, España.
Sociedad Española de Anestesiolog�Ta-Reanimaci�Qn y Terapéutica del Dolor (SEDAR), España; Hospital Universitario Miguel Servet, Zaragoza, España.
Sociedad Española de Anestesiolog�Ta-Reanimaci�Qn y Terapéutica del Dolor (SEDAR), España; Hospital Universitario Virgen de la Victoria, M֙laga, España.
Sociedad Española de Medicina Intensiva, Cr�Ttica y de Unidades Coronarias (SEMICYUC), España; Hospital Universitario La Paz-Carlos III, Madrid, España.
Sociedad Española de Medicina Intensiva, Cr�Ttica y de Unidades Coronarias (SEMICYUC), España; Hospital Universitario Son Espases, Palma de Mallorca, España.
Sociedad Española de Medicina Intensiva, Cr�Ttica y de Unidades Coronarias (SEMICYUC), España; Hospital Universitario de Burgos, Burgos, España.
Sociedad Española de Medicina Intensiva, Cr�Ttica y de Unidades Coronarias (SEMICYUC), España; Hospital Cl�Tnico Universitario, Valencia, España.
Sociedad Española de Medicina Intensiva, Cr�Ttica y de Unidades Coronarias (SEMICYUC), España; Hospital Germans Trias i Pujol, Badalona, España.
AN  - 33023765
AU  - Llau, J. V.
AU  - Ferrandis, R.
AU  - Sierra, P.
AU  - Hidalgo, F.
AU  - Cassinello, C.
AU  - G�Qmez-Luque, A.
AU  - Quintana, M.
AU  - Amezaga, R.
AU  - Geroi, M.
AU  - Serrano, A.
AU  - Marcos, P.
C1  - 10/7/2020
DA  - Sep 6
DB  - PubMed
DO  - 10.1016/j.medin.2020.08.007
DP  - NLM
ET  - 2020/10/08
J2  - Medicina intensiva
LA  - eng
spa
N1  - 1578-6749
Llau, J V
Ferrandis, R
Sierra, P
Hidalgo, F
Cassinello, C
G�Qmez-Luque, A
Quintana, M
Amezaga, R
Geroi, M
Serrano, A
Marcos, P
Letter
Spain
Med Intensiva. 2020 Sep 6:S0210-5691(20)30272-2. doi: 10.1016/j.medin.2020.08.007.
OP  - Consenso SEDAR-SEMICYUC sobre el manejo de las alteraciones de la hemostasia en los pacientes COVID-19 graves.
PY  - 2020
SN  - 0210-5691
ST  - SEDAR-SEMICYUC consensus on the management of haemostasis disorders in severe COVID-19 patients
T2  - Medicina intensiva
TI  - SEDAR-SEMICYUC consensus on the management of haemostasis disorders in severe COVID-19 patients
ID  - 7790880
ER  - 

TY  - JOUR
AB  - Summary Background People living in group situations or with dementia are more vulnerable to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Older people and those with multimorbidity have higher mortality if they become infected than the general population However, no systematic study exists of COVID-19-related outcomes in older inpatients in psychiatric units, who comprise people from these high-risk groups We aimed to describe the period prevalence, demographics, symptoms (and asymptomatic cases), management, and survival outcomes of COVID-19 in the older inpatient psychiatric population and people with young-onset dementia in five National Health Service Trusts in London, UK, from March 1 to April 30, 2020 Methods In this retrospective observational study, we collected demographic data, mental health diagnoses, clinical diagnosis of COVID-19, symptoms, management, and COVID-19-related outcome data of inpatients aged 65 years or older or with dementia who were already inpatients or admitted as inpatients to five London mental health Trusts between March 1 and April 30, 2020, and information about available COVID-19-related resources (ie, testing and personal protective equipment) Patients were determined to have COVID-19 if they had a positive SARS-CoV-2 PCR test, or had relevant symptoms indicative of COVID-19, as determined by their treating physician We calculated period prevalence of COVID-19 and analysed patients�?characteristics, treatments, and outcomes Findings Of 344 inpatients, 131 (38%) were diagnosed with COVID-19 during the study period (period prevalence 38% [95% CI 33�?3]) The mean age of patients who had COVID-19 was 75·3 years (SD 8·2);68 (52%) were women and 47 (36%) from ethnic minority groups 16 (12%) of 131 patients were asymptomatic and 121 (92%) had one or more disease-related comorbidity 108 (82%) patients were compulsorily detained 74 (56%) patients had dementia, of whom 13 (18%) had young-onset dementia On average, sites received COVID-19 testing kits 4·5 days after the first clinical COVID-19 presentation 19 (15%) patients diagnosed with COVID-19 died during the study period, and their deaths were determined to be COVID-19 related Interpretation Patients in psychiatric inpatient settings who were admitted without known SARS-CoV-2 infection had a high risk of infection with SARS-CoV-2 compared with those in the community and had a higher proportion of deaths from COVID-19 than in the community Implementation of the long-standing policy of parity of esteem for mental health and planning for future COVID-19 waves in psychiatric hospitals is urgent Funding None
AU  - Livingston, Gill
AU  - Rostamipour, Hossein
AU  - Gallagher, Paul
AU  - Kalafatis, Chris
AU  - Shastri, Abhishek
AU  - Huzzey, Lauren
AU  - Liu, Kathy
AU  - Sommerlad, Andrew
AU  - Marston, Louise
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Prevalence, management, and outcomes of SARS-CoV-2 infections in older people and those with dementia in mental health wards in London, UK: a retrospective observational study
T2  - Lancet Psychiatry
TI  - Prevalence, management, and outcomes of SARS-CoV-2 infections in older people and those with dementia in mental health wards in London, UK: a retrospective observational study
UR  - https://doi.org/10.1016/S2215-0366(20)30434-X
ID  - 7793007
ER  - 

TY  - JOUR
AB  - Millions of people are helping scientists understand the new coronavirus without leaving their homes, finds Layal Liverpool
AU  - Liverpool, Layal
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Put your computer to work
T2  - New Scientist
TI  - Put your computer to work
UR  - https://doi.org/10.1016/S0262-4079(20)31762-0
ID  - 7793018
ER  - 

TY  - JOUR
AB  - Background The coronavirus disease 2019 (COVID-19) is an emerged respiratory infectious disease with kidney injury as a part of the clinical complications However, the dynamic change of kidney function and its association with COVID-19 prognosis are largely unknown Methods In this multicenter retrospective cohort study, we analyzed clinical characteristics, medical history, laboratory tests, and treatment data of 12,413 COVID-19 patients The patient cohort was stratified according to the severity of the outcome into three groups: non-severe, severe, and death Findings The prevalence of elevated blood urea nitrogen (BUN), elevated serum creatinine (Scr), and decreased blood uric acid (BUA) at admission was 6 29%, 5 22%, 11 66%, respectively The trajectories showed elevation of BUN level and Scr level, as well as a reduction of BUA level during 28 days after admission in death cases Increased all-cause mortality risk was associated with elevated baseline levels of BUN and Scr, and decreased level of BUA Conclusion The dynamic changes of the three kidney function markers were associated with different severity and poor prognosis of COVID-19 patients BUN showed close association and high potential for predicting adverse outcomes in COVID-19 patients for severity stratification and triage
AU  - Liu, Ye-Mao
AU  - Xie, Jing
AU  - Chen, Ming-Ming
AU  - Zhang, Xiao
AU  - Cheng, Xu
AU  - Li, Haomiao
AU  - Zhou, Feng
AU  - Qin, Juan-Juan
AU  - Lei, Fang
AU  - Chen, Ze
AU  - Lin, Lijin
AU  - Yang, Chengzhang
AU  - Mao, Weiming
AU  - Chen, Guohua
AU  - Lu, Haofeng
AU  - Xia, Xigang
AU  - Wang, Daihong
AU  - Liao, Xiaofeng
AU  - Yang, Jun
AU  - Huang, Xiaodong
AU  - Zhang, Bing-Hong
AU  - Yuan, Yufeng
AU  - Cai, Jingjing
AU  - Zhang, Xiao-Jing
AU  - Wang, Yibin
AU  - Zhang, Xin
AU  - She, Zhi-Gang
AU  - Li, Hongliang
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Kidney function indicators predict adverse outcomes of COVID-19
T2  - Med
TI  - Kidney function indicators predict adverse outcomes of COVID-19
UR  - https://doi.org/10.1016/j.medj.2020.09.001
ID  - 7793098
ER  - 

TY  - JOUR
AB  - In this study, we established a simple and practical tool for early identification of potentially high-risk individuals among elderly COVID-19 patients. Included were 2106 laboratory-confirmed COVID-19 patients aged 60 years and above in 30 provinces of mainland China. Using discrimination (the area under the receiver-operator characteristic curve [AUC]) and calibration (Hosmer-Lemeshow goodness-of-fit test and calibration plots), a nomogram for predicting critically ill cases was developed, and its performance was examined using an internal validation cohort (444 patients) and external cohort (770 patients). The proportion of critically ill patients was 11.8% (248/2106). The most common symptoms at the onset of illness were fever (66.6%), cough (34.1%), fatigue (23.3%), and expectoration (23.6%). Older age, history of chronic obstructive pulmonary disease, fever, fatigue, shortness of breath, and lymphocyte percentage lower than 20% at admission were associated with increased risk of becoming critically ill. The AUCs for the six-variable-based nomogram were 0.77 (95% CI: 0.73-0.82), 0.73 (95% CI: 0.67-0.79), and 0.77 (95% CI: 0.71-0.83) in the development, internal validation, and external validation cohorts, respectively. This six-variable-based nomogram could potentially serve as a practical and reliable tool for early identification of elderly COVID-19 patients at high risk of becoming critically ill.
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Research Center of Clinical Epidemiology, Peking University Third Hospital, Beijing, China.
Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
Centre for Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
AN  - 33024057
AU  - Liu, J.
AU  - Tao, L.
AU  - Gao, Z.
AU  - Jiang, R.
AU  - Liu, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.18632/aging.103716
DP  - NLM
ET  - 2020/10/08
J2  - Aging
KW  - Covid-19
coronavirus disease
critically ill
elderly patients
prediction model
LA  - eng
N1  - 1945-4589
Liu, Jue
Tao, Liyuan
Gao, Zhancheng
Jiang, Rongmeng
Liu, Min
Journal Article
United States
Aging (Albany NY). 2020 Oct 6;12. doi: 10.18632/aging.103716.
PY  - 2020
SN  - 1945-4589
ST  - Development and validation of a prediction model for early identification of critically ill elderly COVID-19 patients
T2  - Aging
TI  - Development and validation of a prediction model for early identification of critically ill elderly COVID-19 patients
VL  - 12
ID  - 7790850
ER  - 

TY  - JOUR
AB  - Immunity is a multifaceted phenomenon. For T cell-mediated memory responses to SARS-CoV-2, it is relevant to consider their impact both on COVID-19 disease severity and on viral spread in a population. Here, we reflect on the immunological and epidemiological aspects and implications of pre-existing cross-reactive immune memory to SARS-CoV-2, which largely originates from previous exposure to circulating common cold coronaviruses. We propose four immunological scenarios for the impact of cross-reactive CD4(+) memory T cells on COVID-19 severity and viral transmission. For each scenario, we discuss its implications for the dynamics of herd immunity and on projections of the global impact of SARS-CoV-2 on the human population, and assess its plausibility. In sum, we argue that key potential impacts of cross-reactive T cell memory are already incorporated into epidemiological models based on data of transmission dynamics, particularly with regard to their implications for herd immunity. The implications of immunological processes on other aspects of SARS-CoV-2 epidemiology are worthy of future study.
AD  - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. mlipsitc@hsph.harvard.edu.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. ygrad@hsph.harvard.edu.
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA. alex@lji.org.
Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA. alex@lji.org.
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI), La Jolla, CA, USA. shane@lji.org.
Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), La Jolla, CA, USA. shane@lji.org.
AN  - 33024281
AU  - Lipsitch, M.
AU  - Grad, Y. H.
AU  - Sette, A.
AU  - Crotty, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41577-020-00460-4
DP  - NLM
ET  - 2020/10/08
J2  - Nature reviews. Immunology
LA  - eng
N1  - 1474-1741
Lipsitch, Marc
Orcid: 0000-0003-1504-9213
Grad, Yonatan H
Sette, Alessandro
Crotty, Shane
Orcid: 0000-0002-6484-6262
Journal Article
Review
England
Nat Rev Immunol. 2020 Oct 6. doi: 10.1038/s41577-020-00460-4.
PY  - 2020
SN  - 1474-1733
ST  - Cross-reactive memory T cells and herd immunity to SARS-CoV-2
T2  - Nature reviews Immunology
TI  - Cross-reactive memory T cells and herd immunity to SARS-CoV-2
ID  - 7790828
ER  - 

TY  - JOUR
AB  - This study investigates associations between central aspects of social capital (social trust, group affiliations, civic engagement, confidence in state institutions), income inequality (Gini index for income), and COVID-19 mortality in 84 countries included in different time waves of the World Values Survey (WVS) (Elgar et al , 2020) Comments: First, infectious diseases are either patterned according to socioeconomic status (SES), determined by e g habitus, nutrition and crowded housing or clustering, or not according to SES Second, the focus on economic inequality measured as income inequality (Gini index) should be complemented with measures of wealth inequality (Gini index for wealth), following the globalization process with tax exempted multinational companies Third, the aspects of social capital were measured in different time waves of the World Values Survey (WVS) for different countries, which is a weakness because trust and other aspects of social capital vary over time and depend on specific events and social and economic trends
AU  - Lindström, Martin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A commentary on “The trouble with trust: Time-series analysis of social capital, income inequality, and COVID-19 deaths in 84 countries�?
T2  - Social Science & Medicine
TI  - A commentary on “The trouble with trust: Time-series analysis of social capital, income inequality, and COVID-19 deaths in 84 countries�?
UR  - https://doi.org/10.1016/j.socscimed.2020.113386
ID  - 7793048
ER  - 

TY  - JOUR
AB  - Face masks are recommended to reduce community transmission of SARS CoV 2. One of the primary benefits of face masks and other coverings is as source control devices to reduce the expulsion of respiratory aerosols during coughing, breathing, and speaking. Face shields have been proposed as an alternative to face masks, but information about face shields as source control devices is limited. We used a cough aerosol simulator with a headform to propel small aerosol particles (0 to 7 μm) into different face coverings. An N95 respirator blocked 99% of the cough aerosol, a procedure mask blocked 59%, a 3-ply cloth face mask blocked 51%, and a polyester neck gaiter blocked 47% as a single layer and 60% when folded into a double layer. In contrast, the face shield blocked 2% of the cough aerosol. Our results suggest that face masks and neck gaiters are preferable to face shields as source control devices for cough aerosols.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis research was funded by the National Institute for Occupational Safety and Health (NIOSH), US Centers for Disease Control and Prevention (CDC).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No IRB approval requiredAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesExperimental data is available upon request.
AU  - Lindsley, William G.
AU  - Blachere, Francoise M.
AU  - Law, Brandon F.
AU  - Beezhold, Donald H.
AU  - Noti, John D.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20207241
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20207241
ST  - Efficacy of face masks, neck gaiters and face shields for reducing the expulsion of simulated cough-generated aerosols (preprint)
T2  - medRxiv
TI  - Efficacy of face masks, neck gaiters and face shields for reducing the expulsion of simulated cough-generated aerosols (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.05.20207241.abstract
ID  - 7794713
ER  - 

TY  - JOUR
AB  - Background: Living conditions in homeless shelters may facilitate the transmission of COVID-19. Social determinants and pre-existing health conditions place homeless people at increased risk of severe disease. Described outbreaks in homeless shelters resulted in high proportions of infected residents and staff members. In addition to other infection prevention strategies, regular shelter-wide (universal) testing for COVID-19 may be valuable, depending on the level of community transmission and when resources permit. Methods: This was a prospective feasibility cohort study to evaluate universal testing for COVID-19 at a homeless shelter with 106 beds in Berlin, Germany. Co-researchers were recruited from the shelter staff. A PCR analysis of saliva or self-collected nasal/oral swab was performed weekly over a period of 3 weeks in July 2020. Acceptability and implementation barriers were analyzed by process evaluation using mixed methods including evaluation sheets, focus group discussion and a structured questionnaire. Results: Ninety-three out of 124 (75%) residents were approached to participate in the study. Fifty-one out of the 93 residents (54.8%) gave written informed consent. High retention rates (88.9% - 93.6%) of a weekly respiratory specimen were reached, but repeated collection attempts, as well as assistance were required. A self-collected nasal/oral swab was considered easier and more hygienic to collect than a saliva specimen. No resident was tested positive. Language barriers were the main reason for non-participation. Flexibility of sample collection schedules, the use of video and audio materials, and concise written information were the main recommendations of the co-researchers for future implementation. Conclusion: Voluntary universal testing for COVID-19 is feasible in homeless shelters. Universal testing of high-risk facilities will require flexible approaches, considering the level of the community transmission, the available resources, and the local recommendations. Lack of human resources and laboratory capacity may be a major barrier for implementation of universal testing, requiring adapted approaches compared to standard individual testing. Assisted self-collection of specimens and barrier free communication may facilitate implementation in homeless shelters. Program planning must consider needs and life situation of homeless people, and guarantee confidentiality and autonomy.Competing Interest StatementTK reports to have received honoraria outside of the topic of this study from Total, Newsenselab, Lilly and The BMJ. All other authors have declared no conflicts of interest.Funding StatementThis study was funded by the German Network of University Medicine. The German Network of University Medicine had no role in the design and conduct of the study, analysis, interpretation of data, or in writing of the manuscript.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was approved by the ethics committee of the Charite-Universitatsmedizin (No.: EA4/141/20).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe datasets generated and/or an lyzed during the current study are not publicly available due containing information that could compromise the privacy/consent of the shelter residents but are available from the corresponding author on reasonable request.
AU  - Lindner, Andreas K.
AU  - Sarma, Navina
AU  - Rust, Luise Marie
AU  - Hellmund, Theresa
AU  - Krasovski-Nikiforovs, Svetlana
AU  - Wintel, Mia
AU  - Klaes, Sarah M.
AU  - Hoerig, Merle
AU  - Monert, Sophia
AU  - Schwarzer, Rolf
AU  - Edelmann, Anke
AU  - Equihua Martinez, Gabriela
AU  - Mockenhaupt, Frank P.
AU  - Kurth, Tobias
AU  - Seybold, Joachim
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20205401
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20205401
ST  - Monitoring for COVID-19 by universal testing in a homeless shelter in Germany: a prospective feasibility cohort study (preprint)
T2  - medRxiv
TI  - Monitoring for COVID-19 by universal testing in a homeless shelter in Germany: a prospective feasibility cohort study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20205401.abstract
ID  - 7794749
ER  - 

TY  - JOUR
AB  - PURPOSE: To report bilateral follicular conjunctivitis in two confirmed Coronavirus (COVID-19) patients with the presence of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens. PARTICIPANTS AND METHODS: Two unrelated patients with confirmed SARS-CoV-2 infection and bilateral acute conjunctivitis were examined. Conjunctival swabs were assessed for the presence of SARS-CoV-2 by quantitative real-time polymerase chain reaction (RT-PCR) and viral culture. RESULTS: Both patients developed eye redness 3 days after the onset of COVID-19 symptoms. Slit lamp examination showed bilateral acute follicular conjunctivitis, which was resolved within 6 days. RT-PCR demonstrated the presence of viral RNA in conjunctival specimens from both eyes, which was unrelated to viral RNA from throat swabs. CONCLUSION: SARS-CoV-2 may cause ocular manifestations such as viral conjunctivitis. Conjunctival sampling may be useful for infected patients with conjunctivitis and fever. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection.
AD  - National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore, Singapore.
Tan Tock Seng Hospital , Singapore.
National Centre for Infectious Diseases , Singapore, Singapore.
Programme in Emerging Infectious Diseases, Duke-NUS Medical School , Singapore, Singapore.
Lee Kong Chian School of Medicine , Singapore, Singapore.
Yong Loo Lin School of Medicine , Singapore, Singapore.
Moorfields Eye Hospital, NHS Foundation Trust , London, UK.
AN  - 33021847
AU  - Lim, L. W.
AU  - Tan, G. S.
AU  - Yong, V.
AU  - Anderson, D. E.
AU  - Lye, D. C.
AU  - Young, B.
AU  - Agrawal, R.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/09273948.2020.1821901
DP  - NLM
ET  - 2020/10/07
J2  - Ocular immunology and inflammation
KW  - Covid-19
Conjunctivitis
Coronavirus
Sars-cov2
LA  - eng
N1  - 1744-5078
Lim, Louis W
Tan, Glorijoy S
Yong, Vernon
Anderson, Danielle E
Orcid: 0000-0003-4791-5024
Lye, David C
Young, Barnaby
Agrawal, Rupesh
Orcid: 0000-0002-6662-5850
Journal Article
England
Ocul Immunol Inflamm. 2020 Oct 6:1-5. doi: 10.1080/09273948.2020.1821901.
PY  - 2020
SN  - 0927-3948
SP  - 1-5
ST  - Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections
T2  - Ocular immunology and inflammation
TI  - Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections
ID  - 7791001
ER  - 

TY  - JOUR
AB  - During the COVID-19 pandemic, social distancing measures have made in-person mutual help groups inaccessible to many individuals struggling with substance use disorders (SUDs) Prior to the pandemic, stakeholders in our community had sponsored a program to train volunteers to facilitate local Self-Management and Recovery Training (SMART Recovery) groups As a result, the community established seven weekly SMART Recovery groups, which more than 200 community members attended In March 2020, the community discontinued these groups due to the COVID-19 pandemic To provide SMART Recovery during social distancing, we developed a one-on-one phone-in service for people with SUDs and addictions: the SMART Recovery Line (SMARTline) In this paper, we share our experience training volunteers to facilitate SMART Recovery groups and SMARTline As a result of our experience, we have learned to: (1) establish plans in advance to migrate services from face-to-face settings to remote platforms;(2) consider remote platforms that are easily accessible to the greatest number of individuals;(3) include as many stakeholders in the planning process as possible;(4) consider recruiting volunteers to help in the provision of services, especially since many people want to help fellow community members during crises;and (5) anticipate and prepare for crises well before they occur
AU  - Liese, Bruce S.
AU  - Monley, Corey M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Providing addiction services during a pandemic: Lessons learned from COVID-19
T2  - Journal of Substance Abuse Treatment
TI  - Providing addiction services during a pandemic: Lessons learned from COVID-19
UR  - https://doi.org/10.1016/j.jsat.2020.108156
ID  - 7793112
ER  - 

TY  - JOUR
AB  - Current outbreaks of SARS-CoV-2 are threatening the health care systems of several countries around the world. The control of SARS-CoV-2 epidemics currently relies on non-pharmaceutical interventions, such as social distancing, teleworking, mouth masks and contact tracing. However, as pre-symptomatic transmission remains an important driver of the epidemic, contact tracing efforts struggle to fully control SARS-CoV-2 epidemics. Therefore, in this work, we investigate to what extent the use of universal testing, i.e., an approach in which we screen the entire population, can be utilized to mitigate this epidemic. To this end, we rely on PCR test pooling of individuals that belong to the same households, to allow the for a universal testing procedure that is feasible with the current testing capacity. We evaluate two isolation strategies: on the one hand pool isolation, where we isolate all individuals that belong to a positive PCR test pool, and on the other hand individual isolation, where we determine which of the individuals that belong to the positive PCR pool are positive, through an additional testing step. We evaluate this universal testing approach in the STRIDE individual-based epidemiological model in the context of the Belgian COVID-19 epidemic. As the organisation of universal testing will be challenging, we discuss the different aspects related to sample extraction and PCR testing, to demonstrate the feasibility of universal testing when a decentralized testing approach is used. We show through simulation, that weekly universal testing is able to control the epidemic, even when much of the contact reductions are relieved. Finally, our model shows that, the use of universal testing in combination with stringent contact reductions, could be considered as a strategy to eradicate the virus.Competing Interest StatementBesides his employment at the Hasselt University, JV is part of the investment team of Bioqube Ventures. Bioqube Ventures was not involved in this work, nor does it prosper financially as a result of the current study. The other authors declare that they have no competing interests.Funding StatementLW, TV and NH gratefully acknowledge support from the Fonds voor Wetenschappelijk Onderzoek (FWO) (post-doctoral fellowship 1234620N, doctoral fellowship 1S47617N, and RESTORE project - G0G2920N). This work also received funding from the European Research Council (ERC) under the European Union&#039;s Horizon 2020 research and innovation program (NH, AT: grant number 682540 - TransMID project; NH, PL: grant number 101003688 - EpiPose project). AT acknowledges support from the special research fund of the University of Antwerp. The resources and services used in this work were provided by the VSC (Flemish Supercomputer Center), funded by the Research Foundation - Flanders (FWO) and the Flemish Government. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NAAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe source code for the sim lation model is freely (GPLv3) available on GitHub (universal branch): https://github.com/lwillem/stride. This work generates no new data, except for simulation results, which can be generated from the simulation model source code. All of the data used in our simulation model is mentioned in the reference section.
AU  - Libin, Pieter Jules Karel
AU  - Willem, Lander
AU  - Verstraeten, Timothy
AU  - Torneri, Andrea
AU  - Vanderlocht, Joris
AU  - Hens, Niel
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20205765
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20205765
ST  - Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics (preprint)
T2  - medRxiv
TI  - Assessing the feasibility and effectiveness of household-pooled universal testing to control COVID-19 epidemics (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20205765.abstract
ID  - 7794752
ER  - 

TY  - JOUR
AB  - COVID-19 raised tension both within China and internationally. Here, we used mathematical modeling to predict the trend of patient diagnosis outside China in future, with the aim of easing anxiety regarding the emergent situation. According to all diagnosis number from WHO website and combining with the transmission mode of infectious diseases, the mathematical model was fitted to predict future trend of outbreak. Daily diagnosis numbers from countries outside China were downloaded from WHO situation reports. The data used for this analysis were collected from January 21, 2020 and currently end at February 28, 2020. A simple regression model was developed based on these numbers, as follows: [Formula: see text], where [Formula: see text] is the total diagnosed patient till the i-th day and t=1 at February 1, 2020. Based on this model, we estimate that there were approximately 34 undetected founder patients at the beginning of the spread of COVID-19 outside China. The global trend was approximately exponential, with an increase rate of 10-fold every 19 days. Through establishment of this model, we call for worldwide strong public health actions, with reference to the experiences learned from China and Singapore.
AD  - Ministry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, China.
Institute for Six-sector Economy, Fudan University, Shanghai, China.
Ministry of Education Key Laboratory of Contemporary Anthropology, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai, China lijin@fudan.edu.cn wangyi_fudan@fudan.edu.cn.
Research Institute of Data Sciences, Fudan University, Shanghai, China.
AN  - 33023916
AU  - Li, Y.
AU  - Liang, M.
AU  - Yin, X.
AU  - Liu, X.
AU  - Hao, M.
AU  - Hu, Z.
AU  - Wang, Y.
AU  - Jin, L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/jim-2020-001491
DP  - NLM
ET  - 2020/10/08
J2  - Journal of investigative medicine : the official publication of the American Federation for Clinical Research
KW  - disease management
absence of any commercial or financial relationships that could be construed as a
potential conflict of interest.
LA  - eng
N1  - 1708-8267
Li, Yi
Liang, Meng
Yin, Xianhong
Orcid: 0000-0002-4021-1617
Liu, Xiaoyu
Hao, Meng
Hu, Zixin
Wang, Yi
Jin, Li
Journal Article
England
J Investig Med. 2020 Oct 6:jim-2020-001491. doi: 10.1136/jim-2020-001491.
PY  - 2020
SN  - 1081-5589
ST  - COVID-19 epidemic outside China: 34 founders and exponential growth
T2  - Journal of investigative medicine : official publication of American Federation for Clinical Research
TI  - COVID-19 epidemic outside China: 34 founders and exponential growth
ID  - 7790862
ER  - 

TY  - JOUR
AB  - The clinical manifestations of COVID-19 are mainly respiratory symptoms, but some patients present with cardiovascular system disease such as palpitations and shortness of breath as the first or secondary symptoms. In this paper, we describe the characteristics of SARS-CoV�? and its functional receptor angiotensin-converting enzyme 2 (ACE2). Furthermore, we explore the impact of virus-induced myocardial damage, decreased ACE2 activity, immune imbalance, hypoxemia, and heart damage caused by antiviral drugs.
AD  - Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, 430065, Wuhan, China.
Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, 430065, Wuhan, China. wangqiang@wust.edu.cn.
Institute of Infection, Immunology and Tumor Microenvironment, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Medical College, Wuhan University of Science and Technology, 430065, Wuhan, China. xiaoliu99611@163.com.
AN  - 33025029
AU  - Li, M.
AU  - Chen, S.
AU  - Xiang, X.
AU  - Wang, Q.
AU  - Liu, X.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00059-020-04989-x
DP  - NLM
ET  - 2020/10/08
J2  - Herz
KW  - Angiotensin-converting enzyme 2
Cardiovascular system
Mechanisms
Review
SARS-CoV-2
LA  - eng
N1  - 1615-6692
Li, Mingzhe
Chen, Siyang
Xiang, Xiaochen
Wang, Qiang
Liu, Xiaoliu
Journal Article
Review
Germany
Herz. 2020 Oct 6. doi: 10.1007/s00059-020-04989-x.
OP  - Effekte von SARS-CoV-2 und seinem funktionalen Rezeptor ACE2 auf das Herz-Kreislauf-System.
PY  - 2020
SN  - 0340-9937
ST  - Effects of SARS-CoV-2 and its functional receptor ACE2 on the cardiovascular system
T2  - Herz
TI  - Effects of SARS-CoV-2 and its functional receptor ACE2 on the cardiovascular system
ID  - 7790726
ER  - 

TY  - JOUR
AB  - The pandemic of the coronavirus disease (COVID-19) poses a huge challenge all countries, since no one is well prepared for it To be better prepared for future pandemics, we evaluated association between the internet search data with reported COVID-19 cases to verify whether it could become an early indicator for emerging epidemic After the keyword filtering and Index composition, we found that there were close correlations between Composite Index and suspected cases for COVID-19 (r�?�? 921, P�?amp;lt;�? 05) The Search Index was applied for the Autoregressive Integrated Moving Average with Exogenous Variables (ARIMAX) model to quantify the relationship Compared with the model based on surveillance data only, the ARIMAX model had smaller Akaike Information Criterion (AIC�?�?03 51) and the most accurate predictive values Overall, the Internet search data could serve as a convenient indicator for predicting the epidemic and to monitor its trends
AU  - Li, Kang
AU  - Liang, Yanling
AU  - Li, Jianjun
AU  - Liu, Meiliang
AU  - Feng, Yi
AU  - Shao, Yiming
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Internet search data could Be used as novel indicator for assessing COVID-19 epidemic
T2  - Infectious Disease Modelling
TI  - Internet search data could Be used as novel indicator for assessing COVID-19 epidemic
UR  - https://doi.org/10.1016/j.idm.2020.10.001
ID  - 7793164
ER  - 

TY  - JOUR
AB  - Change is required to ensure effective care during and after covid-19
AN  - 2448515793
AU  - Levene, Louis S.
AU  - Seidu, Samuel
AU  - Greenhalgh, Trish
AU  - Khunti, Kamlesh
C1  - 10/7/2020
DA  - 2020 Oct 05
2020-10-06
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1136/bmj.m3793
DP  - ProQuest Central
KW  - Medical Sciences
COVID-19
Telemedicine
Coronaviruses
Point of care testing
Mortality
Pandemics
England
LA  - English
N1  - Copyright - This article is made freely available for use in accordance with BMJ's website terms and conditions for the duration of the covid-19 pandemic or until otherwise determined by BMJ. You may use, download and print the article for any lawful, non-commercial purpose (including text and data mining) provided that all copyright notices and trade marks are retained. https://bmj.com/coronavirus/usage?
SubjectsTermNotLitGenreText - England
PY  - 2020
ST  - Pandemic threatens primary care for long term conditions
T2  - BMJ
TI  - Pandemic threatens primary care for long term conditions
UR  - https://www.proquest.com/docview/2448515793?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=unknown&sid=ProQ:ProQ%3Asciencejournals&atitle=Pandemic+threatens+primary+care+for+long+term+conditions&title=BMJ+%3A+British+Medical+Journal+%28Online%29&issn=&date=2020-10-05&volume=371&issue=&spage=&au=Levene%2C+Louis+S%3BSeidu%2C+Samuel%3BGreenhalgh%2C+Trish%3BKhunti%2C+Kamlesh&isbn=&jtitle=BMJ+%3A+British+Medical+Journal+%28Online%29&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1136%2Fbmj.m3793
VL  - 371
ID  - 7789879
ER  - 

TY  - JOUR
AB  - COVID-19 is an infection caused by the SARS-CoV-2 virus, initially identified in the city of Wuhan, China, in December 2019. Since then, the virus has spread to the continents, causing a major pandemic. The impacts of this pandemic on the education of human anatomy interfere in at least two aspects: (1) receiving and managing anatomical specimens in anatomy laboratories and (2) adaptations for classes on remote virtual teaching. Therefore, this study reviewed and discussed the legal and bioethical aspects, considering the scenario of a South American Country, aiming to stimulate the debate on these two relevant themes in the international community. Because of the COVID-19 pandemic and the impossibility of mass testing, anatomists and other workers in the field must deal with the risk of receiving bodies infected with SARS-CoV-2. In this situation, additional care measures in biosafety practices are essential to protect the staff. Such measures are: the bodies must be preserved by the perfusion of formaldehyde or other fixative solutions; embalming must be performed in ventilated rooms with a good air exhaust system; to avoid excessive manipulation of bodies and procedures such as pulmonary insufflation or craniotomy; and proper use of personal protective equipment, including lab coat, gloves and masks. As for exposure of body images in online classes, this review showed that there are no legal impediments to this end. However, anatomists must adopt measures aimed at protecting the memory of the deceased, such as using secure digital platforms with restricted access; family authorization/consent and student awareness.
AD  - Universidade Federal de Alagoas, Maceio, Alagoas, Brazil. Electronic address: george.lemos@icbs.ufal.br.
Universidade Federal de Alagoas, Maceio, Alagoas, Brazil.
AN  - 33022405
AU  - Lemos, G. A.
AU  - Araújo, D. N.
AU  - de Lima, F. J. C.
AU  - Bispo, R. F. M.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.aanat.2020.151608
DP  - NLM
ET  - 2020/10/07
J2  - Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft
KW  - Anatomy
Biosafety
Covid-19
Education
SARS-CoV-2
LA  - eng
N1  - 1618-0402
Lemos, George Azevedo
Araújo, Diego Neves
de Lima, Fernando José Camello
Bispo, Rodrigo Freitas Monte
Journal Article
Germany
Ann Anat. 2020 Oct 3:151608. doi: 10.1016/j.aanat.2020.151608.
PY  - 2020
SN  - 0940-9602
SP  - 151608
ST  - Human anatomy education and management of anatomic specimens during and after COVID-19 pandemic: Ethical, legal and biosafety aspects
T2  - Annals of anatomy = Anatomischer Anzeiger : official organ of Anatomische Gesellschaft
TI  - Human anatomy education and management of anatomic specimens during and after COVID-19 pandemic: Ethical, legal and biosafety aspects
ID  - 7790963
ER  - 

TY  - JOUR
AB  - At the end of 2019, a new highly virulent coronavirus known under the name SARS-CoV-2 emerged as a human pathogen One key feature of SARS-CoV-2 is the presence of an enigmatic insertion in the spike glycoprotein gene representing a novel multibasic S1/S2 protease cleavage site The proteolytic cleavage of the spike at this site is essential for viral entry into host cells However, it has been systematically abrogated in structural studies in order to stabilize the spike in the prefusion state In this study, multi-microsecond molecular dynamics simulations and ab initio modeling were leveraged to gain insights into the structures and dynamics of the loop containing the S1/S2 protease cleavage site They unveiled distinct conformations, formations of short helices and interactions of the loop with neighboring glycans that could potentially regulate the accessibility of the cleavage site to proteases and its processing In most conformations, this loop protrudes from the spike, thus representing an attractive SARS-CoV-2 specific therapeutic target
AU  - Lemmin, Thomas
AU  - Kalbermatter, David
AU  - Harder, Daniel
AU  - Plattet, Philippe
AU  - Fotiadis, Dimitrios
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein
T2  - Journal of Structural Biology: X
TI  - Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein
UR  - https://doi.org/10.1016/j.yjsbx.2020.100038
ID  - 7793037
ER  - 

TY  - JOUR
AB  - Background Whereas 5,415 Intensive Care Unit (ICU) beds were initially available, 7,148 COVID-19 patients were hospitalised in the ICU at the peak of the outbreak The present study reports how the French Health Care system created temporary ICU beds to avoid being overwhelmed Methods All French ICUs were contacted for answering a questionnaire focusing on the available beds and health care providers before and during the outbreak Results From 336 institutions with ICUs before the outbreak, 315 (94%) participated, covering 5,054/5,531 (91%) ICU beds During the outbreak, 4,806 new ICU beds (+95% increase) were created from Acute Care Unit (ACU, 2,283), Post Anaesthetic Care Unit and Operating Theatre (PACU &amp; OT, 1,522), other units (374) or real build-up of new ICU beds (627), respectively At the peak of the outbreak, 9,860, 1,982 and 3,089 ICU, ACU and PACU beds were made available Before the outbreak, 3,548 physicians (2,224 critical care anaesthesiologists, 898 intensivists and 275 from other specialties, 151 paediatrics), 1,785 residents, 11,023 nurses and 6,763 nursing auxiliaries worked in established ICUs During the outbreak, 2,524 physicians, 715 residents, 7,722 nurses and 3,043 nursing auxiliaries supplemented the usual staff in all ICUs A total number of 3,212 new ventilators were added to the 5,997 initially available in ICU Conclusion During the COVID-19 outbreak, the French Health Care system created 4,806 ICU beds (+ 95% increase from baseline), essentially by transforming beds from ACUs and PACUs Collaboration between intensivists, critical care anaesthesiologists, emergency physicians as well as the mobilisation of nursing staff were primordial in this context
AU  - Lefrant, Jean-Yves
AU  - Fischer, Marc-Olivier
AU  - Potier, Hugo
AU  - Degryse, Cécile Jaber
AU  - Samir, Muller
AU  - Laurent, Pottecher
AU  - Julien, Charboneau
AU  - Hél؈ne, Meaudre
AU  - Eric, Lanot
AU  - Pierre, Bruckert
AU  - Vincent, Plaud
AU  - Benoît, Dureuil
AU  - Bertrand, Samain
AU  - Emmanuel, Bouaziz
AU  - Hervé, Ecoffey Claude
AU  - Capdevila, Xavier
AU  - Lammens, Stéphane Bonnet
AU  - Vincent, Prevost
AU  - Fabrice, Aussant
AU  - Philippe, Merouani
AU  - Karim, Alaoui
AU  - Samir Sidiki, Kalfon
AU  - Pierre, Mfam
AU  - Willy-Serge, Oilleau
AU  - Jean-Ferréol, Moussa
AU  - Mouhamed, Arab
AU  - Osama Abou, Fellahi
AU  - Jean-Luc, Suzanne
AU  - Stéphanie, Coucoravas
AU  - Jérémy, Espitalier
AU  - Fabien, Bavozet
AU  - Florent, Fermier
AU  - Brice, Vincent
AU  - Jean-François, Ouchikhe
AU  - Abdelali, Herbland
AU  - Alexandre, Godde
AU  - Fréféric, Frasca
AU  - Denis, Desebe
AU  - Oliver, Riu
AU  - Béatrice, Faure
AU  - Henri, Hurel
AU  - Dominique, Bedos
AU  - Jean-Pierre, Lefevres-Scelles
AU  - Antoine, Hayon
AU  - Jan, Chanques
AU  - Gérald, Boutonnet
AU  - Mathieu, Pasquier
AU  - Pierre, Audibert
AU  - Gérard, Mertes
AU  - Paul Michel, Losser
AU  - Marie Reine, Collange
AU  - Olivier, Pottecher
AU  - Thierry, Aubrun
AU  - Frédéric, Payen
AU  - Jean François, Albaladejo
AU  - Pierre, Bouzat
AU  - Pierre, Ichaï Carole Leone
AU  - Marc, Bruder
AU  - Nicolas, Velly
AU  - Lionel, Fourcade
AU  - Olivier, Biais
AU  - Matthieu, Ouattara
AU  - Alexandre, Debaene
AU  - Bertrand, Fizelier
AU  - Claire Dahyot, Asehnoune
AU  - Karim, Lasocki
AU  - Sigismond, Roquilly
AU  - Antoine, Tavernier
AU  - Benoit, Kipnis
AU  - Eric, Lorne
AU  - Emmanuel, Bouhemad
AU  - Belaid, Dupont
AU  - Hervé, Morel Jérome Molliex
AU  - Serge, Beuret
AU  - Pascal, Constantin
AU  - Jean-Michel, Gayat
AU  - Etienne, Mebazaa
AU  - Alexandre, Schoeffler
AU  - Mathieu, Mateu
AU  - Philippe, Verdier
AU  - Philippe
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A National Healthcare Response to Intensive Care Bed Requirements during the COVID-19 Outbreak in France
T2  - Anaesthesia Critical Care & Pain Medicine
TI  - A National Healthcare Response to Intensive Care Bed Requirements during the COVID-19 Outbreak in France
UR  - https://doi.org/10.1016/j.accpm.2020.09.007
ID  - 7793261
ER  - 

TY  - JOUR
AB  - In the middle of the COVID-19 pandemic, I came to think about the role of my identity in my scholarship Drawing on liminality as a conceptual apparatus, this autoethnography displays multiple layers of the self, that is, thresholding, passing, and daydreaming Moving everyday encounters into parts of discourses, I consider how the self is always in full of uncertainty, wandering, rather than being fixed I end with reflecting on the writing process: autoethnographic writing has been continual process to capture multiple liminal moments into a patchwork;it becomes possible by distancing the observing-self from the observed-self, however temporal those are
AU  - Lee, Sun Young
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Now as a Liminal Space, Writing as a Patchwork: Autoethnographic Reflections on the Self in the Middle of the Pandemic
T2  - Qualitative Inquiry
TI  - Now as a Liminal Space, Writing as a Patchwork: Autoethnographic Reflections on the Self in the Middle of the Pandemic
UR  - https://doi.org/10.1177/1077800420960181
ID  - 7792814
ER  - 

TY  - JOUR
AB  - Background: Accurate diagnosis in patients with suspected coronavirus disease 2019 (COVID-19) is essential to guide treatment and limit spread of the virus. The combined nasal and throat swab is used widely, but its diagnostic performance is uncertain. Methods: In a prospective, multi-centre, cohort study conducted in secondary and tertiary care hospitals in Scotland, we evaluated the combined nasal and throat swab with reverse transcriptase-polymerase chain reaction (RT-PCR) for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in consecutive patients admitted to hospital with suspected COVID-19. Diagnostic performance of the index and serial tests was evaluated for a primary outcome of confirmed or probable COVID-19, and a secondary outcome of confirmed COVID-19 on serial testing. The diagnosis was adjudicated by a panel, who recorded clinical, laboratory and radiological features blinded to the test results. Results: We enrolled 1,369 consecutive patients (68 [53-80] years, 47% women) who underwent a total of 3,822 tests (median 2 [1-3] tests per patient). The primary outcome occurred in 36% (496/1,369), of whom 65% (323/496) and 35% (173/496) had confirmed and probable COVID-19, respectively. The index test was positive in 255/496 (51%) patients with the primary outcome, giving a sensitivity and specificity of 51.4% (95% confidence interval [CI] 48.8 to 54.1%) and 99.5% (95% CI 99.0 to 99.8%). Sensitivity increased in those undergoing 2, 3 or 4 tests to 60.1% (95% CI 56.7 to 63.4%), 68.3% (95% CI 64.0 to 72.3%) and 77.6% (95% CI 72.7 to 81.9%), respectively. The sensitivity of the index test was 78.9% (95% CI 74.4 to 83.2%) for the secondary outcome of confirmed COVID-19 on serial testing. Conclusions: In patients admitted to hospital, a single combined nasal and throat swab with RT-PCR for SARS-CoV-2 has excellent specificity, but limited diagnostic sensitivity for COVID-19. Diagnostic performance is significantly improved by repeated testing.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis study was funded by a British Heart Foundation (BHF) Research Excellence Award (RE/18/6134217). DataLochTM is funded by the University of Edinburgh, and the UK and Scottish Governments as part of the Data Driven Innovation in Health &amp;amp; Social Care programme. AA is supported by a Clinical Lectureship from the Chief Scientist Office (PCL/18/05). KL and NLM are supported by a Clinical Research Training Fellowship (FS/18/25/33454) and the Butler Senior Clinical Research Fellowship (FS/16/14/32023) from the British Heart Foundation, respectively. DD is supported by the Medical Research Council (MR/N013166/1). ARC is supported by a Starter Grant for Clinical Lecturers from the Academy of Medical Sciences (SGL021\1075).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was performed with approval of the local Research Ethics Committee and delegated Caldicott Guardian for the National Health Service (NHS) Lothian Health Board, in accordance with the Declaration of Helsinki.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if ap licable.YesAll data were collected from the patient record and national registries, deidentified and linked in a data repository (DataLochTM, Edinburgh, United Kingdom) within a secure safe haven.
AU  - Lee, Kuan Ken
AU  - Doudesis, Dimitrios
AU  - Ross, Daniella
AU  - Bularga, Anda
AU  - MacKintosh, Claire
AU  - Koch, Oliver
AU  - Johannessen, Ingolfur
AU  - Templeton, Kate
AU  - Jenks, Sara
AU  - Chapman, Andrew
AU  - Shah, Anoop
AU  - Anand, Atul
AU  - Perry, Meghan
AU  - Mills, Nicholas L.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206243
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206243
ST  - Diagnostic performance of the combined nasal and throat swab in patients admitted to hospital with suspected COVID-19 (preprint)
T2  - medRxiv
TI  - Diagnostic performance of the combined nasal and throat swab in patients admitted to hospital with suspected COVID-19 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206243.abstract
ID  - 7794750
ER  - 

TY  - JOUR
AB  - It is expected that the coronavirus disease 2019 (COVID-19) pandemic will leave large deficits in the budgets of many jurisdictions Funding for other treatments, in particular new treatments, may become more constrained than previously expected Therefore, a robust health technology assessment (HTA) system is vital Many clinical trials carried out during the pandemic may have been temporarily halted, while others may have had to change their protocols Even trials that continue as normal may experience external changes as other aspects of the healthcare service may not be available to the patients in the trial, or the patients themselves may contract COVID-19 Consequently, many limitations are likely to arise in the provision of robust HTAs, which could have profound consequences on the availability of new treatments Therefore, the National Centre for Pharmacoeconomics Review Group wishes to discuss these issues and make recommendations for applicants submitting to HTA agencies, in ample time for these HTAs to be prepared and assessed We discuss how the pandemic may affect the estimation of the treatment effect, costs, life-years, utilities, discontinuation rates, and methods of evidence synthesis and extrapolation In particular, we note that trials conducted during the pandemic will be subject to a higher degree of uncertainty than before It is vital that applicants clearly identify any parameters that may be affected by the pandemic These parameters will require considerably more scenario and sensitivity analyses to account for this increase in uncertainty
AU  - Leahy, Joy
AU  - Hickey, Conor
AU  - McConnell, David
AU  - Cassidy, Owen
AU  - Trela-Larsen, Lea
AU  - Barry, Michael
AU  - Tilson, Lesley
AU  - McCullagh, Laura
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Coronavirus Disease 2019: Considerations for Health Technology Assessment From the National Centre for Pharmacoeconomics Review Group
T2  - Value in Health
TI  - Coronavirus Disease 2019: Considerations for Health Technology Assessment From the National Centre for Pharmacoeconomics Review Group
UR  - https://doi.org/10.1016/j.jval.2020.09.003
ID  - 7793109
ER  - 

TY  - JOUR
AB  - Daily covid-19 cases are rising across Europe, but is that just because countries are performing more tests? Michael Le Page investigates
AU  - Le Page, Michael
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Europe braces again
T2  - New Scientist
TI  - Europe braces again
UR  - https://doi.org/10.1016/S0262-4079(20)31730-9
ID  - 7793019
ER  - 

TY  - JOUR
AB  - BACKGROUND: Understanding public perceptions of government responses to COVID-19 may foster improved public cooperation. Trust in government and population risk of exposure may influence public perception of the response. Other population-level characteristics, such as country socio-economic development, COVID-19 morbidity and mortality, and degree of democratic government, may influence perception. METHODS AND FINDINGS: We developed a novel ten-item instrument that asks respondents to rate key aspects of their government's response to the pandemic (COVID-SCORE). We examined whether the results varied by gender, age group, education level, and monthly income. We also examined the internal and external validity of the index using appropriate predefined variables. To test for dimensionality of the results, we used a principal component analysis (PCA) for the ten survey items. We found that Cronbach's alpha was 0.92 and that the first component of the PCA explained 60% of variance with the remaining factors having eigenvalues below 1, strongly indicating that the tool is both reliable and unidimensional. Based on responses from 13,426 people randomly selected from the general population in 19 countries, the mean national scores ranged from 35.76 (Ecuador) to 80.48 (China) out of a maximum of 100 points. Heterogeneity in responses was observed across age, gender, education and income with the greatest amount of heterogeneity observed between countries. National scores correlated with respondents' reported levels of trust in government and with country-level COVID-19 mortality rates. CONCLUSIONS: The COVID-SCORE survey instrument demonstrated satisfactory validity. It may help governments more effectively engage constituents in current and future efforts to control COVID-19. Additional country-specific assessment should be undertaken to measure trends over time and the public perceptions of key aspects of government responses in other countries.
AD  - Barcelona Institute for Global Health (ISGlobal), Hospital Cl�Tnic, University of Barcelona, Barcelona, Spain.
Graduate School of Public Health & Health Policy, City University of New York (CUNY), New York, New York, United States of America.
Department of Social and Political Science, Bocconi University, Milan, Italy.
University of Global Health Equity, Kigali, Rwanda.
Emerson College, Boston, Massachusetts, United States of America.
London School of Hygiene and Tropical Medicine, London, United Kingdom.
Department of Health Metrics Sciences, University of Washington, Seattle, Washington, United States of America.
AN  - 33022023
AU  - Lazarus, J. V.
AU  - Ratzan, S.
AU  - Palayew, A.
AU  - Billari, F. C.
AU  - Binagwaho, A.
AU  - Kimball, S.
AU  - Larson, H. J.
AU  - Melegaro, A.
AU  - Rabin, K.
AU  - White, T. M.
AU  - El-Mohandes, A.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240011
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Lazarus, Jeffrey V
Orcid: 0000-0001-9618-2299
Ratzan, Scott
Palayew, Adam
Billari, Francesco C
Binagwaho, Agnes
Orcid: 0000-0002-6779-3151
Kimball, Spencer
Larson, Heidi J
Melegaro, Alessia
Rabin, Kenneth
White, Trenton M
El-Mohandes, Ayman
Orcid: 0000-0001-9538-9220
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0240011. doi: 10.1371/journal.pone.0240011. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240011
ST  - COVID-SCORE: A global survey to assess public perceptions of government responses to COVID-19 (COVID-SCORE-10)
T2  - PloS one
TI  - COVID-SCORE: A global survey to assess public perceptions of government responses to COVID-19 (COVID-SCORE-10)
VL  - 15
ID  - 7790986
ER  - 

TY  - JOUR
AB  - There is a debate in Argentina about the effectiveness of mandatory lockdown measures in containing COVID-19 that lasts five months making it one of the longest in the World. The population effort to comply the lockdown has been decreasing over time given the economic and social costs that it entails. We contributes by analyzing the Argentinian case through information of mobility and contagion given answers to recurrent questions on these topics. This paper aims to fill the gap in the literature by assessing the effects of lockdown measures and the regional relaxation on the numbers of rate of new infections. We also respond to issues of internal political discussion on regional contagion and the effect of marches and unexpected crowd events.We use pool, fixed and random effects panel data modeling and Granger causality tests identifying relations between mobility and contagion. Our results show that lockdown in Argentina has been effective in reducing the mobility but not in way that reduces the rate of contagion. Strict lockdown seems to be effective in short periods of time and by extend it without complementary measures loss effectiveness. Contagion rate seems to be discretely displaced in time and resurging amidst slowly increasing in mobility.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding was received.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:I confirm that all relevant ethical guidelines have been followed.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData is available at the DOI address below.https://doi.org/10.13140/RG.2.2.35693.61922
AU  - Larrosa, Juan M. C.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20203232
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20203232
ST  - Sars-Cov-2 in Argentina: Lockdown, Mobility, and Contagion (preprint)
T2  - medRxiv
TI  - Sars-Cov-2 in Argentina: Lockdown, Mobility, and Contagion (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20203232.abstract
ID  - 7794762
ER  - 

TY  - JOUR
AB  - COVID-19 has highlighted an opportunity for medical professionals to engage in online Public Engagement with Science (PES). Currently a popular platform for PES is Reddit. Reddit provides an Ask Me Anything (AMA) format for subject matter experts to answer questions asked by the public. On March 11, 2020, from 2:00 to 4:00pm EST, two Emergency Department physicians from Massachusetts General Hospital hosted an AMA session on coronavirus. We retroactively conducted an analysis of the questions and answers from this AMA session in order to better understand the public's concerns around coronavirus and identify future opportunities for medical experts to leverage the Reddit AMA format in communicating with the general public. Results suggested that participants sought not only to obtain information, but to engage in discussion, and did so with each other in the absence of expert responses. The majority of bi-directional discussion occurred between participants. Due to the volume of questions and ratio of experts to participants, not all questions were answered. More posts provided facts or opinions, than posts that providing resources or requesting resources.
AD  - Clinical, Educational and Health Psychology Department, University College London, London, United Kingdom.
Kansas City University of Medicine and Biosciences, Kansas City, Missouri, United States of America.
Rocky Vista University College of Medicine, Parker, Colorado, United States of America.
Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
Center for Innovation in Digital HealthCare, Massachusetts General Hospital, Boston, Massachusetts, United States of America.
AN  - 33021985
AU  - Lai, D.
AU  - Wang, D.
AU  - Calvano, J.
AU  - Raja, A. S.
AU  - He, S.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240326
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Lai, Deborah
Wang, Daniel
Orcid: 0000-0003-3488-7052
Calvano, Joshua
Raja, Ali S
He, Shuhan
Orcid: 0000-0002-9902-5077
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0240326. doi: 10.1371/journal.pone.0240326. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240326
ST  - Addressing immediate public coronavirus (COVID-19) concerns through social media: Utilizing Reddit's AMA as a framework for Public Engagement with Science
T2  - PloS one
TI  - Addressing immediate public coronavirus (COVID-19) concerns through social media: Utilizing Reddit's AMA as a framework for Public Engagement with Science
VL  - 15
ID  - 7790993
ER  - 

TY  - JOUR
AB  - OBJECTIVE: The role of renin-angiotensin-aldosterone system (RAAS) blockers during the coronavirus disease 2019 (COVID-19) pandemic is a matter of controversies. Studies based on in-hospital exposure have suggested a beneficial effect of these drugs, unlike those based on chronic exposure. We aimed to analyse RAAS blocker prescription before and during hospital stay in patients with COVID-19, and the corresponding outcomes, to explain these discrepant results. METHODS: In a retrospective cohort study conducted in 347 patients hospitalized for COVID-19 (Bichat Hospital, Paris, France, 23 January-29 April 2020), RAAS blocker exposure, as well as timing and reason for treatment modifications, were collected. The association between exposure and mortality within 30 days of hospital admission was analysed using logistic regression analysis adjusted for age, sex, and comorbidities. RESULTS: Median age was 61 [interquartile range, 51-72] years, 209 (60%) were male, 169 (49%) had a history of treated hypertension, and 117 (34%) received a RAAS blocker prior to hospitalization. RAAS blockers were discontinued within the first 7 days of hospital admission in 33% of previously treated patients (mostly driven by severity of the disease), with a corresponding mortality rate of 33%. Mortality was 8% when treatment was maintained or introduced, and 12% in patients never exposed. Adjusted odds ratios for association between exposure and mortality were 0.62 (95% confidence interval 0.25-1.48) based on chronic exposure and 0.25 (0.09-0.65) based on in-hospital exposure. CONCLUSION: A 'healthy user-sick stopper' bias influences RAAS blocker prescription after hospital admission for COVID-19, and explains the seemingly favourable outcome associated with in-hospital treatment.
AD  - Physiology Department, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital.
INSERM, IAME, UMR 1137, Université de Paris.
Biostatistics, Epidemiology and Clinical Research Department, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital.
Infectious and Tropical Diseases Department, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard University Hospital.
Inserm U1149, Centre for Research on Inflammation, Université de Paris, Paris, France.
AN  - 33021511
AU  - Lahens, A.
AU  - Mullaert, J.
AU  - Gressens, S.
AU  - Gault, N.
AU  - Flamant, M.
AU  - Deconinck, L.
AU  - Joly, V.
AU  - Yazdanpanah, Y.
AU  - Lescure, F. X.
AU  - Vidal-Petiot, E.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1097/hjh.0000000000002658
DP  - NLM
ET  - 2020/10/07
J2  - Journal of hypertension
LA  - eng
N1  - 1473-5598
Lahens, Alexandre
Mullaert, Jimmy
Gressens, Simon
Gault, Nathalie
Flamant, Martin
Deconinck, Laur؈ne
Joly, Véronique
Yazdanpanah, Yazdan
Lescure, François-Xavier
Vidal-Petiot, Emmanuelle
Journal Article
England
J Hypertens. 2020 Oct 5. doi: 10.1097/HJH.0000000000002658.
PY  - 2020
SN  - 0263-6352
ST  - Association between renin-angiotensin-aldosterone system blockers and outcome in coronavirus disease 2019: analysing in-hospital exposure generates a biased seemingly protective effect of treatment
T2  - Journal of hypertension
TI  - Association between renin-angiotensin-aldosterone system blockers and outcome in coronavirus disease 2019: analysing in-hospital exposure generates a biased seemingly protective effect of treatment
ID  - 7791025
ER  - 

TY  - JOUR
AB  - PURPOSE: According to the European Public Health Authority guidance for ending isolation in the context of COVID-19, a convalescent healthcare worker (HCW) can end their isolation at home and resume work upon clinical improvement and two negative RT-PCR tests from respiratory specimens obtained at 24-h intervals at least 8 days after the onset of symptoms. However, convalescent HCWs may shed SARS-CoV-2 viral RNA for prolonged periods. METHODS: 40 healthy HCWs off work because of ongoing positive RT-PCR results in combined nasopharyngeal (NP) and oropharyngeal (OP) swabs following SARS-CoV-2 infection were invited to participate in this study. These HCWs had been in self-isolation because of a PCR-confirmed SARS-CoV-2 infection. NP and OP swabs as well as a blood sample were collected from each participant. RT-PCR and virus isolation was performed with each swab sample and serum neutralization test as well as two different ELISA tests were performed on all serum samples. RESULTS: No viable virions could be detected in any of 29 nasopharyngeal and 29 oropharyngeal swabs taken from 15 long-time carriers. We found SARSCoV- 2 RNA in 14/29 nasopharyngeal and 10/29 oropharyngeal swabs obtained from screening 15 HCWs with previous COVID-19 up to 55 days after symptom onset. Six (40%) of the 15 initially positive HCWs converted to negative and later reverted to positive again according to their medical records. All but one HCW, a healthy volunteer banned from work, showed the presence of neutralizing antibodies in concomitantly taken blood samples. Late threshold cycle (Ct) values in RT-PCR [mean 37.4; median 37.3; range 30.8-41.7] and the lack of virus growth in cell culture indicate that despite the positive PCR results no infectivity remained. CONCLUSION: We recommend lifting isolation if the RT-PCR Ct-value of a naso- or oropharyngeal swab sample is over 30. Positive results obtained from genes targeted with Ct-values  30 correspond to non-viable/noninfectious particles that are still detected by RT-PCR. In case of Ct-values lower than 30, a blood sample from the patient should be tested for the presence of neutralizing antibodies. If positive, non-infectiousness can also be assumed.
AD  - 4th Medical Department with Infectious Diseases and Tropical Medicine, Kaiser Franz Josef Hospital, 1100, Vienna, Austria. hermann.laferl@gesundheitsverbund.at.
4th Medical Department with Infectious Diseases and Tropical Medicine, Kaiser Franz Josef Hospital, 1100, Vienna, Austria.
Austrian Agency for Health and Food Safety (AGES), Institute for Veterinary Disease Control Mödling, 2340, Mödling, Austria.
AN  - 33025521
AU  - Laferl, H.
AU  - Kelani, H.
AU  - Seitz, T.
AU  - Holzer, B.
AU  - Zimpernik, I.
AU  - Steinrigl, A.
AU  - Schmoll, F.
AU  - Wenisch, C.
AU  - Allerberger, F.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s15010-020-01530-4
DP  - NLM
ET  - 2020/10/08
J2  - Infection
KW  - Covid-19
Health care worker
Infectiousness
Isolation
Sars-cv-2
LA  - eng
N1  - 1439-0973
Laferl, H
Kelani, H
Seitz, T
Orcid: 0000-0003-0484-2240
Holzer, B
Zimpernik, I
Steinrigl, A
Schmoll, F
Wenisch, C
Allerberger, F
Journal Article
Germany
Infection. 2020 Oct 6. doi: 10.1007/s15010-020-01530-4.
PY  - 2020
SN  - 0300-8126
ST  - An approach to lifting self-isolation for health care workers with prolonged shedding of SARS-CoV-2 RNA
T2  - Infection
TI  - An approach to lifting self-isolation for health care workers with prolonged shedding of SARS-CoV-2 RNA
ID  - 7790698
ER  - 

TY  - JOUR
AB  - Black, Hispanic, and Indigenous persons in the United States have an increased risk of SARS-CoV-2 infection and death from COVID-19, due to persistent social inequities. The magnitude of the disparity is unclear, however, because race/ethnicity information is often missing in surveillance data. In this study, we quantified the burden of SARS-CoV-2 infection, hospitalization, and case fatality rates in an urban county by racial/ethnic group using combined race/ethnicity imputation and quantitative bias-adjustment for misclassification. After bias-adjustment, the magnitude of the absolute racial/ethnic disparity, measured as the difference in infection rates between classified Black and Hispanic persons compared to classified White persons, increased 1.3-fold and 1.6-fold respectively. These results highlight that complete case analyses may underestimate absolute disparities in infection rates. Collecting race/ethnicity information at time of testing is optimal. However, when data are missing, combined imputation and bias-adjustment improves estimates of the racial/ethnic disparities in the COVID-19 burden.
AN  - 33024980
AU  - Labgold, K.
AU  - Hamid, S.
AU  - Shah, S.
AU  - Gandhi, N. R.
AU  - Chamberlain, A.
AU  - Khan, F.
AU  - Khan, S.
AU  - Smith, S.
AU  - Williams, S.
AU  - Lash, T. L.
AU  - Collin, L. J.
C1  - 10/7/2020
C2  - PMC7536882
DA  - Oct 2
DB  - PubMed
DO  - 10.1101/2020.09.30.20203315
DP  - NLM
ET  - 2020/10/08
J2  - medRxiv : the preprint server for health sciences
LA  - eng
N1  - Labgold, Katie
Hamid, Sarah
Shah, Sarita
Gandhi, Neel R
Chamberlain, Allison
Khan, Fazle
Khan, Shamimul
Smith, Sasha
Williams, Steve
Lash, Timothy Lee
Collin, Lindsay J
Preprint
United States
medRxiv. 2020 Oct 2:2020.09.30.20203315. doi: 10.1101/2020.09.30.20203315. Preprint.
PY  - 2020
ST  - Measuring the missing: greater racial and ethnic disparities in COVID-19 burden after accounting for missing race/ethnicity data
T2  - medRxiv : preprint server for health sciences
TI  - Measuring the missing: greater racial and ethnic disparities in COVID-19 burden after accounting for missing race/ethnicity data
ID  - 7790734
ER  - 

TY  - JOUR
AB  - AIM: To use ultraviolet (UV) radiations in an indigenous method for sterilization of respirators for reuse during COVID-19 outbreak. BACKGROUND: COVID-19 outbreak has infected more than 200 countries. In India, till now, more than 100,000 cases have been reported. Healthcare workers are at high risk of developing infections being in the frontline of taking care of COVDI-19 cases. The demands of personal protective equipment (PPE) are increasing, but the same is not matched with supply due to various reasons. In such scenarios, reusing respirators and face shields is an alternative. UV radiations have quick action and are able to preserve the quality of respirators. We have developed a UV box for surface sterilization of respirators with an intention to reuse. TECHNIQUE: A thermocol box was taken from the central drug store and was fitted with two UV tubes of 254 nm wavelength procured from local service center of water purifiers. The position of the two tubes was such that one was near the base while other was fixed at the top. An aluminum mesh frame was placed in the middle of the box to act as a platform. The roof of the box was converted into a lid. The effectiveness of assembly was tested using culture of Escherichia coli and Staphylococcus aureus. In addition, a biological indicator tube containing test strip with spores of Bacillus atrophaeus was also exposed to UV light for a predefined duration, which did not show any color change after incubation for 48 hours. CONCLUSION: Our prototype assembly with supported efficacy from microbiological tests is an option for use of UV light within available resources for disinfection and reuse of scarce supplies of personal protective equipment. CLINICAL SIGNIFICANCE: UV box can help in meeting the demand supply deficit for respirators, face shields, and goggles that are paramount for the protection of HCW. HOW TO CITE THIS ARTICLE: Kumar P, Chaudhry D, Parmar A, Tyagi D, BG Manjunath, Singh PK. Ultraviolet Box: An Innovative In-house Use of Ultraviolet Irradiation for Conservation of Respirators in COVID-19 Pandemic. Indian J Crit Care Med 2020;24(8):713-715.
AD  - Department of Anaesthesiology and Critical Care, Pt Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
Department of Pulmonary and Critical Care Medicine, Pt Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
Department of Microbiology, Pt Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences, Rohtak, Haryana, India.
AN  - 33024381
AU  - Kumar, P.
AU  - Chaudhry, D.
AU  - Parmar, A.
AU  - Tyagi, D.
AU  - Manjunath, B. G.
AU  - Singh, P. K.
C1  - 10/7/2020
C2  - PMC7519598
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23534
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Covid 19
N95 respirators
Sars-cov-2
UV radiation
LA  - eng
N1  - Kumar, Prashant
Chaudhry, Dhruva
Parmar, Aparna
Tyagi, Diksha
Manjunath, B G
Singh, Pawan Kumar
Journal Article
India
Indian J Crit Care Med. 2020 Aug;24(8):713-715. doi: 10.5005/jp-journals-10071-23534.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 713-715
ST  - Ultraviolet Box: An Innovative In-house Use of Ultraviolet Irradiation for Conservation of Respirators in COVID-19 Pandemic
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - Ultraviolet Box: An Innovative In-house Use of Ultraviolet Irradiation for Conservation of Respirators in COVID-19 Pandemic
VL  - 24
ID  - 7790805
ER  - 

TY  - JOUR
AB  - Globally, telepsychiatry has been around since the 1950s It is in the COVID era that it has gained the relevance and much-needed momentum amongst mental health care professionals Given the restrictions imposed by the global lockdown owing to the fear of contracting the virus, the ease of access and safety offered by telepsychiatry makes it both appealing and ?the new normal ? Despite some hesitation from mental health professionals, there is adequate research to support the role of telehealth services in the management of various mental health disorders As with any formal system, the practice of telepsychiatry is regulated by professional guidelines to show the way forward to both health provider and seeker The manuscript examines the ways telepsychiatry is redefining our virtual conduct It emphasizes the evolving ?netiquette? needed to navigate online consultations It also elucidates the challenges faced by health professionals, and possible ways of maneuvering and circumventing the same Telepsychiatry, a dynamic process which is interactive and personalized, adds a third dimension to the practice of modern medicine It is here to stay So, it is not a question of ?if? instead ?how soon? we can adapt to and get conversant with this revolutionary mode of connection, communication, and consultation, which will make all the difference
AU  - Kumar, Mohan Sunil
AU  - Krishnamurthy, Sharmitha
AU  - Dhruve, Nitya
AU  - Somashekar, Bettahalasoor
AU  - Gowda, Mahesh R.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Telepsychiatry Netiquette: Connect, Communicate and Consult
T2  - Indian Journal of Psychological Medicine
TI  - Telepsychiatry Netiquette: Connect, Communicate and Consult
UR  - https://doi.org/10.1177/0253717620958170
ID  - 7792837
ER  - 

TY  - JOUR
AB  - The coronavirus disease (COVID-19) pandemic has affected nearly all nations globally. The highly contagious nature of the disease puts the healthcare workers at high risk of acquiring infection, especially while handling airway and performing aerosol-generating procedures. The Indian Society of Critical Care Medicine, through this position paper, aims to provide guidance for safe airway management to all healthcare workers dealing with airway in COVID-19 patients. HOW TO CITE THIS ARTICLE: Praveen Kumar G, Kulkarni AP, Govil D, Dixit SB, Chaudhry D, Samavedam S, et al. Airway Management and Related Procedures in Critically Ill COVID-19 Patients: Position Statement of the Indian Society of Critical Care Medicine. Indian J Crit Care Med 2020;24(8):630-642.
AD  - Institute of Critical Care and Anesthesia, Medanta-the Medicity, Gurugram, Haryana, India.
Division of Critical Care Medicine, Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Mumbai, Maharashtra, India.
Department of Critical Care, Sanjeevan and MJM Hospital, Pune, Maharashtra, India.
Department of Pulmonary and Critical Care Medicine, University of Health Sciences, Rohtak, Haryana, India.
Department of Critical Care, Virinchi Hospital, Hyderabad, Telangana, India.
Department of Neuro Trauma Unit, Grant Medical Foundation, Pune, Maharashtra, India.
Division of Critical Care, CARE Hospitals, Hyderabad, Telangana, India.
Institute of Critical Care, Calcutta Medical Research Institute, Kolkata, West Bengal, India.
AN  - 33024367
AU  - Kumar, G. P.
AU  - Kulkarni, A. P.
AU  - Govil, D.
AU  - Dixit, S. B.
AU  - Chaudhry, D.
AU  - Samavedam, S.
AU  - Zirpe, K. G.
AU  - Gopal, P. B.
AU  - Kar, A.
C1  - 10/7/2020
C2  - PMC7519615
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23471
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Aerosol
Airway
Covid-19
Droplets
Extubation
Intubation
Nebulization
Tracheostomy
Videolaryngoscopy
LA  - eng
N1  - Kumar, G Praveen
Kulkarni, Atul P
Govil, Deepak
Dixit, Subhal B
Chaudhry, Dhruva
Samavedam, Srinivas
Zirpe, Kapil G
Gopal, Palepu Bn
Kar, Arindam
Journal Article
India
Indian J Crit Care Med. 2020 Aug;24(8):630-642. doi: 10.5005/jp-journals-10071-23471.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 630-642
ST  - Airway Management and Related Procedures in Critically Ill COVID-19 Patients: Position Statement of the Indian Society of Critical Care Medicine
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - Airway Management and Related Procedures in Critically Ill COVID-19 Patients: Position Statement of the Indian Society of Critical Care Medicine
VL  - 24
ID  - 7790809
ER  - 

TY  - JOUR
AB  - BACKGROUND: �?COVID-19 caused by SARS-CoV-2 leads to myriad range of organ involvement including liver dysfunction. AIM: To analyse the liver function in patients with COVID-19 and their association with respect to age, sex, severity of disease and clinical features. MATERIALS AND METHODS: This study was a cross-sectional study done at Rajendra Institute of Medical Sciences, Ranchi. 91 patients admitted with confirmed SARS-CoV-2 infection were included in this study and divided into asymptomatic, mild, moderate and severe groups. Liver function tests were compared among different severity groups. RESULTS: Of 91 patients with COVID-19, 70 (76.9%) had abnormal liver function. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin levels was 1�? × ULN in 33(36.3%), 34(37.3%), 12(13.2%), 6(6.6%) cases and 2 × ULN in 20(22%), 18(19.8%), 7(7.7%) and 2 (2.2%) cases respectively. Mean AST and ALP levels among different severity groups of COVID-19 was statistically significant (p �?.05) whereas mean ALT and total bilirubin levels was statistically non-significant (p �?.05). There was no statistical difference between males and females with regard to abnormal liver function. Liver injury was seen in 64.3% cases of hypertension and 73.3% cases of diabetes. Fever, myalgia, headache and breathlessness were found to be correlated significantly with severity of disease. CONCLUSION: Liver injury is common in SARS-CoV-2 infection and is more prevalent in the severe disease group. Aspartate transaminase and alkaline phosphatase are better indicators of covid-19 induced liver injury than alanine transaminase and total bilirubin.
AN  - PMC7536590
AU  - Kumar, Abhishek
AU  - Kumar, Piyush
AU  - Dungdung, Ajit
AU  - Kumar Gupta, Anitesh
AU  - Anurag, Aditya
AU  - Kumar, Abhinav
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.dsx.2020.10.001
DP  - NLM
J2  - Diabetes Metab Syndr
KW  - COVID-19
SARS-CoV-2
Liver dysfunction
Clinical profile
ALT,  Alanine transaminase
AST, �? Aspartate transaminase
, ALP, �? Alkaline phosphatase
, ULN, = Upper limit of normal
, COVID-19, �? coronavirus disease-19
, SARS-CoV-2, = Severe acute respiratory syndrome-coronavirus-2
, IQR, �? interquartile range
LA  - eng
N1  - PMC7536590[pmcid]
S1871-4021(20)30389-1[PII]
PY  - 2020
SN  - 1871-4021
1878-0334
ST  - Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients
T2  - Diabetes & Metabolic Syndrome
TI  - Pattern of liver function and clinical profile in COVID-19: A cross-sectional study of 91 patients
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536590/
ID  - 7790666
ER  - 

TY  - JOUR
AB  - The current coronavirus pandemic is imposing unpreceded challenges to the practice of pediatric gastroenterology. These are highlighted in their impact on performing aerosol-generating endoscopy procedures and the need to accommodate longer room turnaround time for disinfection, ensuring appropriate and consistent safety measures for patients, staff and providers, and emphasizing the importance for screening patients for active coronavirus disease (COVID) infection before endoscopy when possible. Pediatric patients are less likely to exhibit severe COVID-related symptoms so survey-based screening would not be a sensitive measure to identify patients with active infections. To address the restrictions of patients coming for face to face clinic encounters, there has been rapid expansion of telehealth services in a very short time period with several difficulties encountered. To survive these challenges, pediatric gastroenterology practices need to adapt and accept flexibility in clinical operations with ongoing commitment to safety for patients and healthcare workers.
AD  - Department of Pediatrics, Central Michigan University/Covenant Medical Center, Saginaw, MI 48602, United States. jkriem@gmail.com.
Division of Pediatric Gastroenterology, University of Iowa Children's Hospital, Iowa, IA 52242, United States.
AN  - 33024391
AU  - Kriem, J.
AU  - Rahhal, R.
C1  - 10/7/2020
C2  - PMC7520606
DA  - Sep 28
DB  - PubMed
DO  - 10.3748/wjg.v26.i36.5387
DP  - NLM
ET  - 2020/10/08
IS  - 36
J2  - World journal of gastroenterology
KW  - Coronavirus
Endoscopy
Gastroenterology
Pandemic
Pediatric
Screening
Telehealth
LA  - eng
N1  - 2219-2840
Kriem, Jamal
Rahhal, Riad
Journal Article
Review
United States
World J Gastroenterol. 2020 Sep 28;26(36):5387-5394. doi: 10.3748/wjg.v26.i36.5387.
PY  - 2020
SN  - 1007-9327
SP  - 5387-5394
ST  - COVID-19 pandemic and challenges in pediatric gastroenterology practice
T2  - World journal of gastroenterology
TI  - COVID-19 pandemic and challenges in pediatric gastroenterology practice
VL  - 26
ID  - 7790803
ER  - 

TY  - JOUR
AB  - Coronaviruses infect many different species including humans. The last two decades have seen three zoonotic coronaviruses with SARS-CoV-2 causing a pandemic in 2020. Coronaviral non-structural proteins (nsp) built up the replication-transcription complex (RTC). Nsp7 and nsp8 interact with and regulate the RNA-dependent RNA-polymerase and other enzymes in the RTC. However, the structural plasticity of nsp7+8 complex has been under debate. Here, we present the framework of nsp7+8 complex stoichiometry and topology based on a native mass spectrometry and complementary biophysical techniques of nsp7+8 complexes from seven coronaviruses in the genera Alpha - and Betacoronavirus including SARS-CoV-2. Their complexes cluster into three groups, which systematically form either heterotrimers or heterotetramers or both, exhibiting distinct topologies. Moreover, even at high protein concentrations mainly heterotetramers are observed for SARS-CoV-2 nsp7+8. From these results, the different assembly paths can be pinpointed to specific residues and an assembly model is proposed.
AN  - 33024972
AU  - Krichel, B.
AU  - Bylapudi, G.
AU  - Schmidt, C.
AU  - Blanchet, C.
AU  - Schubert, R.
AU  - Brings, L.
AU  - Koehler, M.
AU  - Zenobi, R.
AU  - Svergun, D.
AU  - Lorenzen, K.
AU  - Madhugiri, R.
AU  - Ziebuhr, J.
AU  - Uetrecht, C.
C1  - 10/7/2020
C2  - PMC7536876
DA  - Sep 30
DB  - PubMed
DO  - 10.1101/2020.09.30.320762
DP  - NLM
ET  - 2020/10/08
J2  - bioRxiv : the preprint server for biology
LA  - eng
N1  - Krichel, Boris
Bylapudi, Ganesh
Schmidt, Christina
Blanchet, Clement
Schubert, Robin
Brings, Lea
Koehler, Martin
Zenobi, Renato
Svergun, Dmitri
Lorenzen, Kristina
Madhugiri, Ramakanth
Ziebuhr, John
Uetrecht, Charlotte
Orcid: 0000-0002-1991-7922
Preprint
United States
bioRxiv. 2020 Sep 30:2020.09.30.320762. doi: 10.1101/2020.09.30.320762. Preprint.
PY  - 2020
ST  - Hallmarks of Alpha - and Betacoronavirus non-structural protein 7+8 complexes
T2  - bioRxiv : preprint server for biology
TI  - Hallmarks of Alpha - and Betacoronavirus non-structural protein 7+8 complexes
ID  - 7790742
ER  - 

TY  - JOUR
AD  - German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Department of Pediatric Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
German Center for Neurodegenerative Diseases (DZNE), Berlin, Germany. harald.pruess@dzne.de.
Department of Neurology and Experimental Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany. harald.pruess@dzne.de.
AN  - 33024283
AU  - Kreye, J.
AU  - Reincke, S. M.
AU  - Prüss, H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41577-020-00458-y
DP  - NLM
ET  - 2020/10/08
J2  - Nature reviews. Immunology
LA  - eng
N1  - 1474-1741
Kreye, Jakob
Reincke, S Momsen
Prüss, Harald
Orcid: 0000-0002-8283-7976
Journal Article
England
Nat Rev Immunol. 2020 Oct 6. doi: 10.1038/s41577-020-00458-y.
PY  - 2020
SN  - 1474-1733
ST  - Do cross-reactive antibodies cause neuropathology in COVID-19?
T2  - Nature reviews Immunology
TI  - Do cross-reactive antibodies cause neuropathology in COVID-19?
ID  - 7790827
ER  - 

TY  - JOUR
AB  - Why are existing global governance structures “not fit for purpose�?when it comes to addressing complex global catastrophic risks (CGCRs) such as climate breakdown, ecosystem collapse, or parasitic artificial general intelligence? This article argues that a deeper appreciation of these risks as complex—as opposed to complicated—is vital to an effective global governance response It joins other IR scholarship seeking to invigorate a rigorous research agenda on complex system dynamics within world politics, highlighting the value of complexity theory, not simply as a contextual descriptor, but as a conceptual toolkit to inform CGCR governance research and action Taking seriously the implications of “restricted complexity,�?it interrogates why the legacy governing toolkit—the assumptions, heuristics, models, and practices conventionally employed to solve international collective action problems—are unlikely to suffice It further draws laterally upon design science to offer a novel design model for governing complex systems, with broad application across global policy domains A case study of the COVID-19 pandemic response illustrates the importance of supplementing inherited “complicated�?governance system design and practices with design principles explicitly oriented to working with complexity, rather than against it We contend that IR scholars and practitioners must update old ways of thinking in light of a complexification of the discipline Such a shift involves both revisiting the design logics underlying how we build global governance structures, as well as pursuing a generative research agenda more capable of responding adequately to instability, surprise, and extraordinary change
AU  - Kreienkamp, Julia
AU  - Pegram, Tom
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Governing Complexity: Design Principles for the Governance of Complex Global Catastrophic Risks
T2  - International Studies Review
TI  - Governing Complexity: Design Principles for the Governance of Complex Global Catastrophic Risks
UR  - https://doi.org/10.1093/isr/viaa074
ID  - 7792901
ER  - 

TY  - JOUR
AU  - Kregting, L.
AU  - Kaljouw, S.
AU  - de Jonge, L.
AU  - Jansen, E. E. L.
AU  - Peterse, E. F. P.
AU  - Heijnsdijk, E. A. M.
AU  - van Ravesteyn, N. T.
AU  - Lansdorp-Vogelaar, I.
AU  - de Kok, I. M. C. M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - 24 - Effects of cancer screening restart strategies after COVID-19 disruption
T2  - European Journal of Cancer
TI  - 24 - Effects of cancer screening restart strategies after COVID-19 disruption
UR  - https://doi.org/10.1016/S0959-8049(20)30561-X
ID  - 7793017
ER  - 

TY  - JOUR
AB  - In 2017, the National Association of School Psychologists described tele-assessment as the least researched area of telehealth This became problematic in 2020 when COVID-19 curtailed the administration of face-to-face assessments Publishers began to offer computer-adapted tele-assessment methods for tests that had only previously been administered in person Recommendations for adapted tele-assessment practice had to be developed with little empirical data The current study analyzed recommendations from entities including professional organizations, test publishers, and governmental offices The samples for each were small, but the findings were noteworthy Test publishers were unanimous in recommending the use of their face-to-face assessments through adapted tele-assessment methods (either with or without caution) Governmental agencies were more likely to recommend not using adapted tele-assessment methods or to use these methods with caution Finally, professional organizations were almost unanimous in their recommendations to use adapted tele-assessment but to do so with caution In addition to deviations in the types of recommendations provided, entities varied in how the information was distributed About one-fifth (23 5%) of all entities surveyed provided no recommendations at all About 45% of the remaining entities provided recommendations on their Web sites The rest provided information through shared documents, online toolkits, peer-reviewed journals, and emails Implications for the field of psychology?s future crisis management planning are discussed in response to these findings
AU  - Krach, Shelley Kathleen
AU  - Paskiewicz, Tracy L.
AU  - Monk, Malaya M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Testing Our Children When the World Shuts Down: Analyzing Recommendations for Adapted Tele-Assessment during COVID-19
T2  - Journal of Psychoeducational Assessment
TI  - Testing Our Children When the World Shuts Down: Analyzing Recommendations for Adapted Tele-Assessment during COVID-19
UR  - https://doi.org/10.1177/0734282920962839
ID  - 7792832
ER  - 

TY  - JOUR
AU  - Kordshakeri, Parnian
AU  - Fazeli, Ehsan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - How the COVID-19 pandemic highlights the lack of accessible public spaces in Tehran
T2  - Cities & Health
TI  - How the COVID-19 pandemic highlights the lack of accessible public spaces in Tehran
UR  - https://doi.org/10.1080/23748834.2020.1817690
ID  - 7792938
ER  - 

TY  - JOUR
AU  - Kong, Y. J.
AU  - Shaver, L. G.
AU  - Shi, F. Y.
AU  - Yang, L. X.
AU  - Zhang, W. G.
AU  - Wei, X. L.
AU  - Wang, Yiran
AU  - Wang, P. P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Belief and Usage of Traditional Chinese Medicine as Preventative Measure against COVID-19 Infection During the Pandemic among Chinese Immigrants in Canada
T2  - Annals of Epidemiology
TI  - Belief and Usage of Traditional Chinese Medicine as Preventative Measure against COVID-19 Infection During the Pandemic among Chinese Immigrants in Canada
UR  - https://doi.org/10.1016/j.annepidem.2020.08.027
ID  - 7793234
ER  - 

TY  - JOUR
AB  - The two panelists will elaborate on &#039;four practical problems and six ethical objections&#039;, which add up to one very bad idea, i e , the &#039;immunity passport&#039; Such an idea is equal to restricting movement on the basis of biology threatens freedom, fairness and public health Lessons from previous pandemics will be examined in the context of current measures being deployed, assessing practical and ethical aspects For example, false negatives in people with few antibodies leading to immune individuals being incorrectly labelled as not immune or not having access to testing to demonstrate immunity Additionally, the case of healthcare workers will be examined considering feasibility of testing, but also in terms of discrimination and stigma Another aspect to be explored in detail is monitoring and how it erodes privacy, with the main aim of immunity passport controlling movement Documentation systems are already presenting a serious risk to privacy, with China announcing the QR-code tracking systems is likely to stay in place after the pandemic ends
AU  - Kofler, N.
AU  - Baylis, F.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Examining ‘immunity passports�?from an ethics perspective �?ten reasons why they are bad idea
T2  - European Journal of Public Health
TI  - Examining ‘immunity passports�?from an ethics perspective �?ten reasons why they are bad idea
UR  - https://doi.org/10.1093/eurpub/ckaa165.498
ID  - 7792682
ER  - 

TY  - JOUR
AB  - The incubation period of SARS-CoV-2 is rarely greater than 14 days. We report a patient with hypogammaglobulinemia who developed SARS-CoV-2 infection with a confirmed incubation period of at least 21 days. These findings raise concern for a prolonged presymptomatic transmission phase, necessitating a longer quarantine duration in this patient population.
AD  - Department of Internal Medicine, Section of Infectious Diseases, University of California Davis, Davis, CA, USA.
Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, CT, USA.
Departments of Immunobiology and Cell Biology, Yale University School of Medicine, New Haven, CT.
AN  - 33023685
AU  - Koff, A.
AU  - Laurent-Rolle, M.
AU  - Hsu, J. C.
AU  - Malinis, M.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1017/ice.2020.1239
DP  - NLM
ET  - 2020/10/08
J2  - Infection control and hospital epidemiology
KW  - Covid-19
SARS-CoV-2
immunosuppressed host
incubation period
LA  - eng
N1  - 1559-6834
Koff, Alan
Orcid: 0000-0003-1229-7860
Laurent-Rolle, Maudry
Orcid: 0000-0002-1446-0142
Hsu, Jack Chun-Chieh
Malinis, Maricar
Orcid: 0000-0002-5720-9994
Journal Article
United States
Infect Control Hosp Epidemiol. 2020 Oct 7:1-10. doi: 10.1017/ice.2020.1239.
PY  - 2020
SN  - 0899-823x
SP  - 1-10
ST  - Prolonged incubation of SARS-CoV-2 in a Patient on Rituximab Therapy
T2  - Infection control and hospital epidemiology
TI  - Prolonged incubation of SARS-CoV-2 in a Patient on Rituximab Therapy
ID  - 7790887
ER  - 

TY  - JOUR
AU  - Koenen, Melissa
AU  - Balvert, Marleen
AU  - Brekelmans, R. C. M.
AU  - Fleuren, Hein
AU  - Stienen, Valentijn
AU  - Wagenaar, Joris
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - SARS-CoV-2, Simulation model, Epidemiologic, Virus and disease progression characteristics
PY  - 2020
ST  - Forecasting the Spread of Sars-Cov-2 is Inherently Ambiguous Given the Current State of Virus Research (preprint)
T2  - SSRN
TI  - Forecasting the Spread of Sars-Cov-2 is Inherently Ambiguous Given the Current State of Virus Research (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3702170
ID  - 7794793
ER  - 

TY  - JOUR
AB  - What did NICE say? NICE’s summary, which looked specifically at emerging evidence on the role of vitamin D in relation to covid-19, concluded that there is currently no evidence to support supplements reducing the risk or severity of covid-19.2 The Scientific Advisory Commission on Nutrition also studied whether vitamin D supplementation could reduce the risk of acute respiratory tract infections other than covid-19, and concluded that the jury was still out.3 Any more bones you can throw me? Adrian Martineau has updated his 2017 BMJ4 meta-analysis of vitamin D’s effects on respiratory tract infections, which is currently on a preprint server and not yet peer reviewed.5 He told The BMJ, “The antiviral and anti-inflammatory actions of vitamin D make it an interesting candidate for prevention of viral respiratory infections. In Scotland the government has similar advice for times when �?-15 minutes of unprotected Scottish sun exposure�?is not possible.6 1 Torjesen I. Evidence does not support vitamin D for reducing respiratory infections, reviews conclude.
AN  - 2448515540
AU  - Kmietowicz, Zosia
C1  - 10/7/2020
DA  - 2020 Oct 05
2020-10-06
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1136/bmj.m3872
DP  - ProQuest Central
KW  - Medical Sciences
Infections
Dietary supplements
Respiratory tract diseases
COVID-19
Supplementation
Coronaviruses
Vitamin D
Reviews
Systematic review
Meta-analysis
Inflammation
LA  - English
N1  - Copyright - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go tohttp://group.bmj.com/group/rights-licensing/permissions2020BMJ
PY  - 2020
ST  - Sixty seconds on . . . vitamin D
T2  - BMJ
TI  - Sixty seconds on . . . vitamin D
UR  - https://www.proquest.com/docview/2448515540?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Asciencejournals&atitle=Sixty+seconds+on+.+.+.+vitamin+D&title=BMJ+%3A+British+Medical+Journal+%28Online%29&issn=&date=2020-10-05&volume=371&issue=&spage=&au=Kmietowicz%2C+Zosia&isbn=&jtitle=BMJ+%3A+British+Medical+Journal+%28Online%29&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1136%2Fbmj.m3872
VL  - 371
ID  - 7789881
ER  - 

TY  - JOUR
AB  - The spike protein of the SARS-CoV-2 interacts with angiotensin converting enzyme 2 (ACE2) and enters the host cell by receptor-mediated endocytosis. Concomitantly, evidence is pointing to the involvement of additional host cell receptors, such as integrins. The cytoplasmic tails of ACE2 and integrin beta3 contain a plethora of predicted binding motifs. Here, we confirm the functionality of some of these motifs through affinity measurements. The class I PDZ binding motif in the ACE2 cytoplasmic tail binds the first PDZ domain of the scaffold protein NHERF3. The clathrin-adaptor subunit AP2 Mu2 interacts with an endocytic motif in the ACE2 with low affinity and the interaction is abolished by phosphorylation of Tyr781. Furthermore, the C-terminal region of integrin beta3 contains a LC3-interacting region, and its interaction with ATG8 domains is enhanced by phosphorylation. Together, our data provides possible molecular links between host cell receptors and endocytosis and autophagyCompeting Interest StatementThe authors have declared no competing interest.
AU  - Kliche, Johanna
AU  - Ali, Muhammad
AU  - Ivarsson, Ylva
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.327742
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.327742
ST  - Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to endocytosis and autophagy (preprint)
T2  - bioRxiv
TI  - Cytoplasmic short linear motifs in ACE2 and integrin beta3 link SARS-CoV-2 host cell receptors to endocytosis and autophagy (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.327742.abstract
ID  - 7794717
ER  - 

TY  - JOUR
AU  - Kirkland, P. D.
AU  - Frost, M. J.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The impact of viral transport media on PCR assay results for the detection of nucleic acid from SARS-CoV-2
T2  - Pathology
TI  - The impact of viral transport media on PCR assay results for the detection of nucleic acid from SARS-CoV-2
UR  - https://doi.org/10.1016/j.pathol.2020.09.013
ID  - 7793084
ER  - 

TY  - JOUR
AB  - In the UK, one in two people will develop cancer during their lifetimes and radiotherapy (RT) plays a key role in effective treatment. High energy proton beam therapy commenced in the UK National Health Service in 2018. Heavier charged particles have potential advantages over protons by delivering more dose in the Bragg peak, with a sharper penumbra, lower oxygen dependence and increased biological effectiveness. However, they also require more costly equipment including larger gantries to deliver the treatment. There are significant uncertainties in the modelling of relative biological effectiveness and the effects of the fragmentation tail which can deliver dose beyond the Bragg peak. These effects need to be carefully considered especially in relation to long-term outcomes.In 2019, a group of clinicians, clinical scientists, engineers, physical and life scientists from academia and industry, together with funding agency stakeholders, met to consider how the UK should address new technologies for RT, especially the use of heavier charged particles such as helium and carbon and new modes of delivery such as FLASH and spatially fractionated radiotherapy (SFRT).There was unanimous agreement that the UK should develop a facility for heavier charged particle therapy, perhaps constituting a new National Ion Research Centre to enable research using protons and heavier charged particles. Discussion followed on the scale and features, including which ions should be included, from protons through helium, boron, and lithium to carbon, and even oxygen. The consensus view was that any facility intended to treat patients must be located in a hospital setting while providing dedicated research space for physics, preclinical biology and clinical research with beam lines designed for both in vitro and in vivo research. The facility should to be able to investigate and deliver both ultra-high dose rate FLASH RT and SFRT (GRID, minibeams etc.). Discussion included a number of accelerator design options and whether gantries were required. Other potential collaborations might be exploited, including with space agencies, electronics and global communications industries and the nuclear industry.In preparation for clinical delivery, there may be opportunities to send patients overseas (for (12)C or (4)He ion therapy) using the model of the National Health Service (NHS) Proton Overseas Programme and to look at potential national clinical trials which include heavier ions, FLASH or SFRT. This could be accomplished under the auspices of NCRI CTRad (National Cancer Research Institute, Clinical and Translational Radiotherapy Research Working Group).The initiative should be a community approach, involving all interested parties with a vision that combines discovery science, a translational research capability and a clinical treatment facility. Barriers to the project and ways to overcome them were discussed. Finally, a set of different scenarios of features with different costs and timelines was constructed, with consideration given to the funding environment (prer-Covid-19) and need for cross-funder collaboration.
AD  - Division of Cancer Sciences, University of Manchester, Manchester Cancer Research Centre, Manchester Academic Health Science Centre, Manchester, United Kingdom.
The Christie NHS Foundation Trust, University of Manchester, Manchester, UK.
University of Manchester/Cockcroft Institute, Manchester, United Kingdom.
Christie Medical Physics and Engineering, The Christie NHS Foundation Trust, Manchester, UK.
NHS England National Clinical Lead Proton Beam Therapy, Leeds Cancer Centre, Leeds Teaching Hospitals Trust, Leeds, UK.
St James's Institute of Oncology, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
Department of Medical Physics, University Hospital Birmingham, Birmingham, Edgbaston, UK.
AN  - 33021102
AU  - Kirkby, K. J.
AU  - Kirkby, N. F.
AU  - Burnet, N. G.
AU  - Owen, H.
AU  - Mackay, R. I.
AU  - Crellin, A.
AU  - Green, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1259/bjr.20200247
DP  - NLM
ET  - 2020/10/07
J2  - The British journal of radiology
LA  - eng
N1  - 1748-880x
Kirkby, Karen Joy
Orcid: 0000-0002-0901-210x
Kirkby, Norman Francis
Burnet, Neil Gunn
Owen, Hywel
Mackay, Ranald Iain
Crellin, Adrian
Green, Stuart
Journal Article
England
Br J Radiol. 2020 Oct 6:20200247. doi: 10.1259/bjr.20200247.
PY  - 2020
SN  - 0007-1285
SP  - 20200247
ST  - Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer
T2  - British journal of radiology
TI  - Heavy charged particle beam therapy and related new radiotherapy technologies: The clinical potential, physics and technical developments required to deliver benefit for patients with cancer
ID  - 7791050
ER  - 

TY  - JOUR
AU  - Kidane, Biniam
AU  - Levin, Daniel P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Identification and Resolution of Asymptomatic Coronavirus Disease 2019 Pneumonitis and Colitis: Serial Assessment of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Evaluation of Lung Cancer
T2  - Journal of Thoracic Oncology
TI  - Identification and Resolution of Asymptomatic Coronavirus Disease 2019 Pneumonitis and Colitis: Serial Assessment of Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography for Evaluation of Lung Cancer
UR  - https://doi.org/10.1016/j.jtho.2020.09.004
ID  - 7793110
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has disrupted the lives of people worldwide In this study, we assessed the burden of stress during the pandemic and its relationship with eating practices in a national random sample of American adults Data were collected using an online survey and the participants were asked about their demographic characteristics, perceived stress, and eating practices in April 2020 Compared to their counterparts, average stress scores were statistically significantly higher for racial and ethnic minority individuals, those who were employed part-time, were single, lived in the Midwest, and were &amp;le;35 years of age More than one-tenth of the participants reported practicing more unhealthy eating practices during the pandemic lockdowns: fasting (16%), restricting eating (20%), skipping meals (25%), and overeating (39%) Concerning the overall perception of diet, nearly a third reported that their diet had worsened during the pandemic (31%) In adjusted and unadjusted analyses after controlling for demographic characteristics, stress scores were statistically significantly higher for those engaging in unhealthy eating practices and those who reported that their diet had worsened Policymakers and public health practitioners should redouble their efforts in preventing morbidity and premature mortality by implementing interventions that address the multiple detrimental stressors of the COVID-19 pandemic
AU  - Khubchandani, Jagdish
AU  - Kandiah, Jayanthi
AU  - Saiki, Diana
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The COVID-19 Pandemic, Stress, and Eating Practices in the United States
T2  - European Journal of Investigation in Health, Psychology and Education
TI  - The COVID-19 Pandemic, Stress, and Eating Practices in the United States
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813222
ID  - 7793353
ER  - 

TY  - JOUR
AB  - BACKGROUND: Burnout, a state of physical and emotional exhaustion, in healthcare workers (HCWs) is a major concern. The prevalence of burnout, due to COVID-19 pandemic in India, is unknown. We therefore conducted this survey. MATERIALS AND METHODS: A questionnaire-based survey using Copenhagen Burnout Inventory was carried out among HCWs looking after COVID-19 patients. Questionnaire was sent to the HCWs, using WhatsApp Messenger, and voluntary participation was sought. We received responses from 2026 HCWs. Burnout was assessed in personal, work, and client-related (COVID-19 pandemic-related) domains. Burnout was defined at a cut-off score of 50 for each domain. RESULTS: The prevalence of personal burnout was 44.6% (903), work-related burn-out was only 26.9% (544), while greater than half of the respondents (1,069, 52.8%) had pandemic-related burnout. Younger respondents (21-30 years) had higher personal and work-related burnout. The prevalence of personal and work-related burnout was significantly (p  0.01) higher among females. The doctors were 1.64 times, and the support staff were 5 times more likely to experience pandemic-related burnout. CONCLUSION: There is a significant prevalence of burnout during the COVID-19 pandemic among HCWs, in particular, doctors and support staff. Female respondents had higher prevalence. We suggest that the management should be proactive and supportive in improving working conditions and providing assurance to the HCWs. The long-term effects of the current pandemic need to be assessed later. HOW TO CITE THIS ARTICLE: Khasne RW, Dhakulkar BS, Mahajan HC, Kulkarni AP. Burnout among Healthcare Workers during COVID-19 Pandemic in India: Results of a Questionnaire-based Survey. Indian J Crit Care Med 2020;24(8):664-671.
AD  - Department of Critical Care Medicine, Ashoka Medicover Hospital, Wadala, Nashik, Maharashtra, India.
Department of Anesthesiology, Ashoka Medicover Hospital, Wadala, Nashik, Maharashtra, India.
Division of Critical Care Medicine, Department of Anesthesia, Critical Care and Pain, Tata Memorial Hospital, Homi Bhabha National Institute, Parel (E), Mumbai, Maharashtra, India.
AN  - 33024372
AU  - Khasne, R. W.
AU  - Dhakulkar, B. S.
AU  - Mahajan, H. C.
AU  - Kulkarni, A. P.
C1  - 10/7/2020
C2  - PMC7519601
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23518
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Burnout
COVID-19 pandemic
Copenhagen burnout inventory
Mental health
LA  - eng
N1  - Khasne, Ruchira W
Dhakulkar, Bhagyashree S
Mahajan, Hitendra C
Kulkarni, Atul P
Journal Article
India
Indian J Crit Care Med. 2020 Aug;24(8):664-671. doi: 10.5005/jp-journals-10071-23518.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 664-671
ST  - Burnout among Healthcare Workers during COVID-19 Pandemic in India: Results of a Questionnaire-based Survey
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - Burnout among Healthcare Workers during COVID-19 Pandemic in India: Results of a Questionnaire-based Survey
VL  - 24
ID  - 7790806
ER  - 

TY  - JOUR
AB  - Current scenario depicts that world has been clenched by COVID-19 pandemic Inevitably, public health and safety measures could be undertaken in order to dwindle the infection threat and mortality Moreover, to overcome the global menace and drawing out world from moribund stage, there is an exigency for social distancing and quarantines Since December, 2019, coronavirus, SARS-CoV-2 (COVID-19) have came into existence and up till now world is still in the state of shock At this point of time, COVID-19 has entered perilous phase, creating havoc among individuals, and this has been directly implied due to enhanced globalisation and ability of the virus to acclimatize at all conditions The unabated transmission is due to lack of drugs, vaccines and therapeutics against this viral outbreak But research is still underway to formulate the vaccines or drugs by this means, as scientific communities are continuously working to unravel the pharmacologically active compounds that might offer a new insight for curbing infections and pandemics Therefore, the topical COVID-19 situation highlights an immediate need for effective therapeutics against SARS-CoV-2 Towards this effort, the present review discusses the vital concepts related to COVID-19, in terms of its origin, transmission, clinical aspects and diagnosis However, here, we have formulated the novel concept hitherto, ancient means of traditional medicines or herbal plants to beat this pandemic
AU  - Khanna, Kanika
AU  - Kohli, Sukhmeen Kaur
AU  - Kaur, Ravdeep
AU  - Bhardwaj, Abhay
AU  - Bhardwaj, Vinay
AU  - Ohri, Puja
AU  - Sharma, Anket
AU  - Ahmad, Ajaz
AU  - Bhardwaj, Renu
AU  - Ahmad, Parvaiz
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Herbal Immune-boosters: Substantial Warriors of Pandemic Covid-19 Battle
T2  - Phytomedicine
TI  - Herbal Immune-boosters: Substantial Warriors of Pandemic Covid-19 Battle
UR  - https://doi.org/10.1016/j.phymed.2020.153361
ID  - 7793078
ER  - 

TY  - JOUR
AB  - BACKGROUND: Patients with red eyes frequently present to general practitioners (GPs). Although infrequent, some patients with COVID-19 may present with features typical of viral conjunctivitis. SARS-CoV-2 is expressed at a low rate in tears, which may be a source of infection to GPs caring for patients at high risk of COVID�?9. OBJECTIVE: The aims of this article are to outline: 1) ophthalmic complications of SARS-CoV-2 infection, 2) triage and management of patients with potential COVID-19 conjunctivitis, and 3) triage and management of patients with red eyes during the current COVID-19 pandemic. DISCUSSION: It is important that GPs: 1) have a high index of suspicion that patients with apparently typical viral conjunctivitis may have an uncommon presentation of COVID-19 illness, 2) develop appropriate telephone triage systems to reduce patient consultations, and 3) foster relationships with their ophthalmologist and optometrist colleagues who can provide phone advice, guidance on treatment initiation and definitive care when necessary.
AD  - MBBS, FRCOphth, FRANZCO, MD, Chair of Public Health Committee, The Royal Australian and New Zealand College of Ophthalmologists, NSW; Clinical Senior Lecturer, University of Western Australia, WA; Consultant Ophthalmologist, Royal Perth Hospital, WA.
PhD, FRANZCO, Clinical Associate Professor of Ophthalmology, Department of Surgery (Ophthalmology), University of Melbourne, Vic.
AN  - 33015681
AU  - Khan, J.
AU  - Mack, H. G.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.31128/ajgp-04-20-5356
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Australian journal of general practice
LA  - eng
N1  - 2208-7958
Khan, Jane
Mack, Heather G
Journal Article
Australia
Aust J Gen Pract. 2020 Oct;49(10):656-661. doi: 10.31128/AJGP-04-20-5356.
PY  - 2020
SP  - 656-661
ST  - Management of conjunctivitis and other causes of red eye during the COVID-19 pandemic
T2  - Australian journal of general practice
TI  - Management of conjunctivitis and other causes of red eye during the COVID-19 pandemic
VL  - 49
ID  - 7791353
ER  - 

TY  - JOUR
AB  - Background NCIT are non-invasive devices for fever screening in children However, evidence of their accuracy for fever screening in adults is lacking This study aimed to compare the accuracy of non-contact infrared thermometers (NCIT) with temporal artery thermometers (TAT) in an adult hospital Methods A prospective observational study was conducted on a convenience sample of non-infectious inpatients in two Australian hospitals NCIT and TAT devices were used to collect body temperature recordings Participant characteristics included age, gender, skin colour, highest temperature and antipyretic medications recorded in last 24-hours Results In 265 patients, a mean difference of �u0 26��C was recorded between the NCIT (36 64��C) and the reference TAT (36 90��C) temperature devices Bland-Altman analysis showed that NCIT and TAT temperatures were closely aligned at temperatures 37 5��C NCIT had low sensitivity (16 13%) at temperatures �?7 5��C An AUROC score of 0 67 (SD 0 05) demonstrated poor accuracy of the NCIT device at temperatures �?7 5��C Conclusion This is the first study to compare accuracy of NCIT thermometers to TAT in adult patients Although mass fever screening is currently underway using NCIT, these results indicate that the NCIT may not be the most accurate device for fever mass screening during a pandemic
AU  - Khan, Dr Shahrukh
AU  - Saultry, Ms Bridey
AU  - Adams, Dr Scott
AU  - Kouzani, Dr Abbas Z.
AU  - Decker, Ms Kelly
AU  - Digby, Dr Robin
AU  - Bucknall, Alfred Deakin Professor Tracey
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Comparative accuracy testing of non-contact infrared thermometers and temporal artery thermometers in an adult hospital setting
T2  - American Journal of Infection Control
TI  - Comparative accuracy testing of non-contact infrared thermometers and temporal artery thermometers in an adult hospital setting
UR  - https://doi.org/10.1016/j.ajic.2020.09.012
ID  - 7792689
ER  - 

TY  - JOUR
AU  - Khalil, Asma
AU  - von Dadelszen, Peter
AU  - Kalafat, Erkan
AU  - Sebghati, Mercede
AU  - Ladhani, Shamez
AU  - Ugwumadu, Austin
AU  - Draycott, Tim
AU  - Brien, Pat
AU  - Magee, Laura
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Change in obstetric attendance and activities during the COVID-19 pandemic
T2  - Lancet Infectious Diseases
TI  - Change in obstetric attendance and activities during the COVID-19 pandemic
UR  - https://doi.org/10.1016/S1473-3099(20)30779-9
ID  - 7793012
ER  - 

TY  - JOUR
AB  - Standardized patients (SPs) are laypersons trained to portray patients, family members, and others in a consistent, measurable manner to teach and assess healthcare students, and to provide practice for emotionally and medically challenging cases. SP methodology has been studied with practicing genetic counselors; however, there is minimal empirical evidence characterizing its use in genetic counseling (GC) education. The Accreditation Council for Genetic Counseling (ACGC) Standards of Accreditation for Graduate Programs in Genetic Counseling include SP sessions as one way to achieve up to 20% of the 50 participatory cases required for graduation. The purpose of the current project was to determine the scope, frequency, and timing of SP methodology in ACGC-accredited programs to establish baseline usage, which happened prior to the SARS-CoV-2 pandemic. A 40-item investigator-created survey was developed to document the scope and frequency of SP use among programs. The survey was distributed through the Association of Genetic Counseling Program Directors' (AGCPD) listserv to 43 accredited and 6 programs under development. Surveys were analyzed from 25 accredited programs (response rate = 58%). Seventeen of these programs report inclusion of SP methodology in the curricula (68%), of which 13 report working with an established SP program. SPs are used predominantly for role-plays (70.6%), individualized instruction and remediation (29.4%), and for other reasons such as lecture demonstration, final examinations, practicing skills, and assessing students' goals. Sixteen of the participating programs use SPs to give GC students experience disclosing positive test results. Other details vary among the GC programs including the use of trained SPs, volunteer or paid SPs, actors with and without SP training, or GC students acting as patients. This study demonstrates that GC program SP experiences differ, but are largely viewed as valuable by the programs. Many GC programs report using SP encounters to create multiple opportunities for students to practice and refine clinical skills similar to SPs in medical school.
AD  - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Perelman School of Medicine, Standardized Patient Program, University of Pennsylvania, PA, USA.
Department of Psychology, Elizabethtown College, Elizabethtown, PA, USA.
Department of Genetic Counseling, Arcadia University Genetic Counseling Graduate Program, Glenside, PA, USA.
AN  - 33025686
AU  - Kessler, L. J.
AU  - LaMarra, D.
AU  - MacFarlane, I. M.
AU  - Heller, M.
AU  - Valverde, K. D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/jgc4.1335
DP  - NLM
ET  - 2020/10/08
J2  - Journal of genetic counseling
KW  - education
genetic counseling
standardized patients
supervision
LA  - eng
N1  - 1573-3599
Kessler, Lisa Jay
LaMarra, Denise
MacFarlane, Ian M
Heller, Melissa
Valverde, Kathleen D
Journal Article
United States
J Genet Couns. 2020 Oct 6. doi: 10.1002/jgc4.1335.
PY  - 2020
SN  - 1059-7700
ST  - Characterizing standardized patients and genetic counseling graduate education
T2  - Journal of genetic counseling
TI  - Characterizing standardized patients and genetic counseling graduate education
ID  - 7790686
ER  - 

TY  - JOUR
AB  - As of 15 August 2020, Coronavirus disease 2019 (COVID-19) has been reported in 21 million people world-wide and is responsible for more than 750,000 deaths. The occurrence of acute kidney injury (AKI) in patients hospitalized with COVID-19 has been reported to be as high as 43%. This is comparable to AKI in other forms of pneumonia requiring hospitalization, as well as in non-infectious conditions like cardiac surgery. The impact of AKI on COVID-19 outcomes is difficult to assess at present but, similar to other forms of sepsis, AKI is strongly associated with hospital mortality. Indeed, mortality is reported to be very low in COVID-19 patients without AKI. Given that AKI contributes to fluid and acid-base imbalances, compromises immune response and may impair resolution of inflammation, it seems likely that AKI contributes to mortality in these patients. The pathophysiologic mechanisms of AKI in COVID-19 are thought to be multifactorial including systemic immune and inflammatory responses induced by viral infection, systemic tissue hypoxia, reduced renal perfusion, endothelial damage and direct epithelial infection with Severe Acute Respiratory Syndrome Coronavirus 2. Mitochondria play a central role in the metabolic deregulation in the adaptive response to the systemic inflammation and are also found to be vital in response to both direct viral damage and tissue reperfusion. These stress conditions are associated with increased glycolysis and reduced fatty acid oxidation. Thus, there is a strong rationale to target AKI for therapy in COVID-19. Furthermore, many approaches that have been developed for other etiologies of AKI such as sepsis, inflammation and ischemia-reperfusion, have relevance in the treatment of COVID-19 AKI and could be rapidly pivoted to this new disease.
AD  - Department of Critical Care Medicine, The Center for Critical Care Nephology, University of Pittsburgh School of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Medical and Development, Astellas Pharma Inc., Tokyo, Japan.
Mitobridge, An Astellas Company, Cambridge, MA, USA.
AN  - 33022712
AU  - Kellum, J. A.
AU  - van Till, J. W. O.
AU  - Mulligan, G.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1093/ndt/gfaa231
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
KW  - Aki
Covid-19
mitochondria
mortality
sepsis
LA  - eng
N1  - 1460-2385
Kellum, John A
van Till, J W Olivier
Mulligan, George
Journal Article
England
Nephrol Dial Transplant. 2020 Oct 1;35(10):1652-1662. doi: 10.1093/ndt/gfaa231.
PY  - 2020
SN  - 0931-0509
SP  - 1652-1662
ST  - Targeting acute kidney injury in COVID-19
T2  - Nephrology, dialysis, transplantation : official publication of European Dialysis and Transplant Association - European Renal Association
TI  - Targeting acute kidney injury in COVID-19
VL  - 35
ID  - 7790952
ER  - 

TY  - JOUR
AB  - Fermented products are mainly produced at the household level and consumed as stable foods by local people, and sold on local markets;majority of them are unknown by up-market population Recently, public information on potential health benefits of fermented products increased the demand for them and consumers�?willingness to pay, especially during COVID-19 Integration of these products to the global market is essential for food security, sustainable production, success of the food market, and the economy of the country However, pre- and post-processing contamination and product inconsistency constitute a major challenge to the market value of traditional food products The Failure Mode and Effect Analysis (FMEA) was applied for quantification of risk analysis of ten traditional fermented beverages that majority of them are virtually less well known outside of the specific regions of Turkey Generally speaking, high risk priority numbers, (RPN�?20), were commonly observed in majority of productions since they were using intensive human handling, applying obsolete technologies, and employing people that have no food processing and hygiene training It is concluded that improving a technology and integration of local peoplecentered, knowledge-based support programs were required for sustainable production of these products Comprehensive real data collected from visits to farms located in different regions of Turkey over six years were used for the analysis Results from this study may help manufacturers from different parts of the world in producing safer fermented beverages that share common ingredients, equipment, and manufacturing stages
AU  - Kavsara, Hasan Kaan
AU  - Ozilgen, Sibel
AU  - Dagdeviren, Musa
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Safeguarding Grandma’s Fermented Beverage Recipes for Food Security: Food Safety Challenges
T2  - International Journal of Gastronomy and Food Science
TI  - Safeguarding Grandma’s Fermented Beverage Recipes for Food Security: Food Safety Challenges
UR  - https://doi.org/10.1016/j.ijgfs.2020.100266
ID  - 7793163
ER  - 

TY  - JOUR
AU  - Kaur, Parminder
AU  - Patel, Prem
AU  - Singh, Balraj
AU  - Guragai, Nirmal
AU  - Vasudev, Rahul
AU  - Virk, Hartaj S.
AU  - Shamoon, Fayez
AU  - Bikkina, Mahesh
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - ST-Segment Elevation in Patients with COVID-19—A late Complication
T2  - American Journal of Medical Sciences
TI  - ST-Segment Elevation in Patients with COVID-19—A late Complication
UR  - https://doi.org/10.1016/j.amjms.2020.09.019
ID  - 7793247
ER  - 

TY  - JOUR
AB  - BACKGROUND: The novel coronavirus disease 2019 (COVID-19) infected over 5 million United States (US) residents resulting in more than 180,000 deaths by August 2020. To mitigate transmission, most states ordered shelter-in-place orders in March and reopening strategies varied. OBJECTIVE: To estimate excess COVID-19 cases and deaths after reopening compared with trends prior to reopening for two groups of states: (1) states with an evidence-based reopening strategy, defined as reopening indoor dining after implementing a statewide mask mandate, and (2) states reopening indoor dining rooms before implementing a statewide mask mandate. DESIGN: Interrupted time series quasi-experimental study design applied to publicly available secondary data. PARTICIPANTS: Fifty United States and the District of Columbia. INTERVENTIONS: Reopening indoor dining rooms before or after implementing a statewide mask mandate. MAIN MEASURES: Outcomes included daily cumulative COVID-19 cases and deaths for each state. KEY RESULTS: On average, the number of excess cases per 100,000 residents in states reopening without masks is ten times the number in states reopening with masks after 8 weeks (643.1 cases; 95% confidence interval (CI)�?�?06.9, 879.2 and 62.9 cases; CI�?�?2.6, 113.1, respectively). Excess cases after 6 weeks could have been reduced by 90% from 576,371 to 63,062 and excess deaths reduced by 80% from 22,851 to 4858 had states implemented mask mandates prior to reopening. Over 50,000 excess deaths were prevented within 6 weeks in 13 states that implemented mask mandates prior to reopening. CONCLUSIONS: Additional mitigation measures such as mask use counteract the potential growth in COVID-19 cases and deaths due to reopening businesses. This study contributes to the growing evidence that mask usage is essential for mitigating community transmission of COVID-19. States should delay further reopening until mask mandates are fully implemented, and enforcement by local businesses will be critical for preventing potential future closures.
AD  - Margolis Center for Health Policy, Duke University, Durham, NC, USA. Brystana.kaufman@duke.edu.
Population Health Sciences, Duke University, Durham, NC, USA. Brystana.kaufman@duke.edu.
Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Medical Center, Durham, NC, USA. Brystana.kaufman@duke.edu.
Margolis Center for Health Policy, Duke University, Durham, NC, USA.
Population Health Sciences, Duke University, Durham, NC, USA.
Center of Innovation to Accelerate Discovery and Practice Transformation (ADAPT), Durham VA Medical Center, Durham, NC, USA.
Division of General Internal Medicine, Department of Medicine, Duke University, Durham, NC, USA.
AN  - 33021717
AU  - Kaufman, B. G.
AU  - Whitaker, R.
AU  - Lederer, N. M.
AU  - Lewis, V. A.
AU  - McClellan, M. B.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11606-020-06277-0
DP  - NLM
ET  - 2020/10/07
J2  - Journal of general internal medicine
LA  - eng
N1  - 1525-1497
Kaufman, Brystana G
Orcid: 0000-0001-6553-0406
Whitaker, Rebecca
Lederer, Nirosha Mahendraratnam
Lewis, Valerie A
McClellan, Mark B
Journal Article
United States
J Gen Intern Med. 2020 Oct 6. doi: 10.1007/s11606-020-06277-0.
PY  - 2020
SN  - 0884-8734
ST  - Comparing Associations of State Reopening Strategies with COVID-19 Burden
T2  - Journal of general internal medicine
TI  - Comparing Associations of State Reopening Strategies with COVID-19 Burden
ID  - 7791009
ER  - 

TY  - JOUR
AB  - Although the preparedness to health emergencies of biological, chemical, environmental and unknown origin across the Europe is at high level, gaps do exist across the EU Member States and European countries The previous coronavirus epidemic, SARS in 2002, showed that countries responded largely individually to this emerging threat EU wide, joint responses were not taken SARS epidemic showed that strengthening of the common EU efforts was needed Many actions were taken, and since 2013 the European Commission Decision 1082/2013/EU on serious cross-border threats to health has provided a framework to improve preparedness and to strengthen the response capacities in Europe to health threats SHARP Joint Action is a 3-year collaborative action of 26 countries and 61 partners, co-funded by the EC and coordinated by the Finnish Institute for Health and Welfare, Finland, and co-coordinated by Robert Koch Institute, Germany and National Institute of Infectious Diseases Lazzaro Spallanzani, Italy SHARP started it&#039;s actions in June 2019, and it aims to strengthen implementation of the International Health Regulations (IHR) and the Decision 1082/2013/EU SHARP consists of ten work packages covering core public health capacities, including: IHR core capacity strengthening and assessment, preparedness and response planning, training, laboratory preparedness and responsiveness, chemical safety and threats, and case management, infection prevention and control preparedness Through this cross-sectoral approach, SHARP supports the Member States and partner countries in strengthening their capacities In response to the COVID-19 outbreak, SHARP has also supported the EC and the Member States, and especially work packages for laboratory preparedness and responsiveness (WP7) and for case management and infection prevention and control preparedness (WP10) were activated The activities regarding laboratory preparedness and response have been coordinated with the ECDC Key messages SHARP Joint Action strengthens the implementation of Decision 1082/2013/EU on serious cross-border threats to health and the implementation of International Health Regulations in the EU SHARP improves preparedness and response to serious cross-border threats to health, and resilience of the health systems at national, EU and regional level
AU  - Katz, A.
AU  - Karvonen, O.
AU  - Di Caro, A.
AU  - Vairo, F.
AU  - Ippolito, G.
AU  - Grunow, R.
AU  - Jacob, D.
AU  - Salminen, M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - SHARP Joint Action �?Strengthening International Health Regulations and preparedness in the EU
T2  - European Journal of Public Health
TI  - SHARP Joint Action �?Strengthening International Health Regulations and preparedness in the EU
UR  - https://doi.org/10.1093/eurpub/ckaa166.606
ID  - 7792907
ER  - 

TY  - JOUR
AB  - The aim of this paper is the generation of a time-series based statistical data-driven procedure in order to track an outbreak At first are used univariate time series models in order to predict the evolution of the reported cases Moreover, are considered combinations of the models in order to provide more accurate and robust results Additionally, statistical probability distributions are considered in order to generate future scenarios Final step is the build and use of an epidemiological model (tSIR) and the calculation of an epidemiological ratio (R0) for estimating the termination of the outbreak The time series models include Exponential Smoothing and ARIMA approaches from the classical models, also Feed-Forward Artificial Neural Networks and Multivariate Adaptive Regression Splines from the machine learning toolbox Combinations include simple mean, Newbolt-Granger and Bates-Granger approaches Finally, the tSIR model and the R0 ratio are used for estimating the spread and the reversion of the pandhemic The suggested procedure is used to track the COVID-19 epidemic in Greece This epidemic has appeared in China in December 2019 and has been widespread since then to all over the world Greece is the center of this empirical study as is considered an early successful paradigm of resistance against the virus
AU  - Katris, Christos
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A Time Series-Based Statistical Approach for Outbreak Spread Forecasting: Application of COVID-19 in Greece
T2  - Expert Systems with Applications
TI  - A Time Series-Based Statistical Approach for Outbreak Spread Forecasting: Application of COVID-19 in Greece
UR  - https://doi.org/10.1016/j.eswa.2020.114077
ID  - 7793179
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has caused teachers and students to abandon their physical classrooms and move into emergency distance education (EDE) settings Thus, sustaining the quality in education has become a challenge during this transitional period Within this context, the aim of this study was to explore the impact of EDE on language skills development (reading, writing, listening, and speaking) of Turkish pre-service teachers of English as a foreign language (EFL) In this qualitative study, data were gathered from 118 pre-service EFL teachers about the advantages and disadvantages of EDE for their language skills development Thematic analysis was used as a research design, and nine themes emerged for both advantages and disadvantages The most important two themes for both categories are content and implementation of online courses and teacher&amp;rsquo;s role This study pinpointed the eminence of these two themes, for if they are emphasized enough and handled efficiently, they play a huge role in developing language skills The themes and sub-themes generated through thematic analysis showed the advantages and disadvantages of EDE for each skill in detail and also proved that EDE was most advantageous for writing skill and least advantageous for speaking skill The participants stated that, since writing skill was constantly used for almost all homework, assignments and projects, that skill was nurtured the most Nevertheless, speaking skill was ignored during online courses, and writing became the new mode of communication by replacing speaking The outcome of the present study encourages preparedness for EDE against a possible second wave Thus, the study is hoped to pave the way for anticipating issues and developing solutions for EDE contexts to preserve sustainability in higher education
AU  - Karataş, Tuçe Öztürk Tuncer
AU  - Hülya
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Sustaining Language Skills Development of Pre-Service EFL Teachers despite the COVID-19 Interruption: A Case of Emergency Distance Education
T2  - Sustainability
TI  - Sustaining Language Skills Development of Pre-Service EFL Teachers despite the COVID-19 Interruption: A Case of Emergency Distance Education
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813219
ID  - 7793354
ER  - 

TY  - JOUR
AB  - BACKGROUND: Covid-19 associated coagulopathy (CAC) is associated with prothrombotic state and thromboembolism. However, true incidence of thromboembolic events is difficult to determine in the ICU setting. The aim of our study was to investigate the cumulative incidence of thromboembolic events in Covid-19 patients needing intensive care unit (ICU) admission and assessing the utility of point of care ultrasound (POCUS) to screen for and diagnose lower extremity deep venous thrombosis (DVT). METHODS: We conducted a prospective observational study between April 22nd and May 26th, 2020 where all adult patients with the diagnosis of Covid-19 pneumonia admitted to 8 ICUs of Montefiore Medical Center were included. POCUS exam was performed on all patients at day 1 of ICU admission and at day 7 and 14 after the first exam. RESULTS: The primary outcome was to study the cumulative incidence of thromboembolic events in Covid-19 patients needing ICU admission. A total of 107 patients were included. All patients got POCUS exam on day 1 in the ICU, 62% got day 7 and 41% got day 14 exam. POCUS diagnosed 17 lower extremity DVTs on day 1, 3 new on day 7 and 1 new on day 14. Forty patients developed 52 thromboembolic events, with the rate of 37.3%. We found a high 45-day cumulative incidence of thromboembolic events of 37% and a high 45-day cumulative incidence of lower and upper extremity DVT of 21% and 10% respectively. Twelve (30%) patients had failure of therapeutic anticoagulation. Occurrence of a thromboembolic event was not associated with a higher risk of mortality (HR 1.08, p value = .81). CONCLUSIONS: Covid-19 patients in ICU have a high cumulative incidence of thromboembolic events, but not associated with higher mortality. POCUS is an excellent tool to help screen and diagnose DVT during a pandemic.
AD  - Division of Critical Care Medicine, Department of Internal Medicine, 2013Montefiore Medical Center, Bronx, NY, USA.
Department of Epidemiology and Population Health, 2006Albert Einstein College of Medicine, Bronx, NY, USA.
Division of Critical Care Medicine, Division of Pulmonary Medicine, Department of Internal Medicine, Montefiore Medical Center, Bronx, NY, USA.
AN  - 33021131
AU  - Kapoor, S.
AU  - Chand, S.
AU  - Dieiev, V.
AU  - Fazzari, M.
AU  - Tanner, T.
AU  - Lewandowski, D. C.
AU  - Nalla, A.
AU  - Abdulfattah, O.
AU  - Aboodi, M. S.
AU  - Shiloh, A. L.
AU  - Gong, M. N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0885066620964392
DP  - NLM
ET  - 2020/10/07
J2  - Journal of intensive care medicine
KW  - Covid-19
Icu
Pocus
incidence
mortality
thrombosis
LA  - eng
N1  - 1525-1489
Kapoor, Sumit
Orcid: 0000-0002-5683-3445
Chand, Sudham
Dieiev, Vladyslav
Fazzari, Melissa
Tanner, Tristan
Lewandowski, David C
Nalla, Anil
Abdulfattah, Omar
Orcid: 0000-0002-7092-3631
Aboodi, Michael S
Shiloh, Ariel L
Gong, Michelle N
Journal Article
United States
J Intensive Care Med. 2020 Oct 6:885066620964392. doi: 10.1177/0885066620964392.
PY  - 2020
SN  - 0885-0666
SP  - 885066620964392
ST  - Thromboembolic Events and Role of Point of Care Ultrasound in Hospitalized Covid-19 Patients Needing Intensive Care Unit Admission
T2  - Journal of intensive care medicine
TI  - Thromboembolic Events and Role of Point of Care Ultrasound in Hospitalized Covid-19 Patients Needing Intensive Care Unit Admission
ID  - 7791049
ER  - 

TY  - JOUR
AU  - Kaplan, Jason G.
AU  - Kanwal, Arjun
AU  - Malek, Ryan
AU  - Dickey, John Q.
AU  - Keirn, Richard
AU  - Zweig, Bryan
AU  - Minter, David
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 resulting in bilateral pulmonary emboli and a right ventricular thrombus: association or causation? A case report
T2  - European Heart Journal - Case Reports
TI  - COVID-19 resulting in bilateral pulmonary emboli and a right ventricular thrombus: association or causation? A case report
UR  - https://doi.org/10.1093/ehjcr/ytaa276
ID  - 7792921
ER  - 

TY  - JOUR
AB  - COVID-19 has affected the internal migrants in India badly When the government announced a lockdown with a 4-hour notice, millions of these migrants, who were a part of the vast unorganized labor force to be found in urban areas, were left stranded In our article, we analyze the structural factors that underpin this crisis We argue that the migrant crisis that unfolded in the urban areas has its roots in India?s embrace of globalization, the rise of capitalistic agriculture, and the increasing casualization of labor work in the urban labor markets
AU  - Kandikuppa, Sandeep
AU  - Gupta, Pallavi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Capitalist agriculture and the creation of the circular migrant: Understanding COVID-19’s impact on internal migrants in India
T2  - Human Geography
TI  - Capitalist agriculture and the creation of the circular migrant: Understanding COVID-19’s impact on internal migrants in India
UR  - https://doi.org/10.1177/1942778620963543
ID  - 7792808
ER  - 

TY  - JOUR
AB  - BACKGROUND: Coagulopathy and thromboembolic events are common in Covid-19 patients and are poor prognostic factors. Controversy exists regarding the potential of anticoagulation (AC) to reduce mortality and incidence of thromboembolic events in Covid-19 patients. The current systematic review and meta-analysis investigated the association between anticoagulants and mortality in adult hospitalized COVID-19 patients using the available published non-randomized studies. METHODS: Google Scholar, PubMed, Scopus, the Cochrane Library and Clinical Trials.gov were searched for relevant studies. A meta-analysis of adjusted and unadjusted estimates was performed. The relative risk was used as a measure of effect. The random-effects model was used to pool estimates using the generic inverse variance method. RESULTS: Sixteen studies were included in the quantitative data synthesis. Results showed a statistically significant association between AC and mortality (RR = 0.56, 95% CI 0.36; 0.92, p = 0.02). Both therapeutic (Relative risk [RR] = 0.4, 95% CI 0.27; 0.57) and prophylactic AC (RR = 0.54, 95% CI 0.41; 0.71) were associated with lower risk of mortality. Pre-admission AC was not associated with mortality (RR = 0.84, 95% CI 0.49; 1.43, p  0.05) while prophylactic AC was associated with higher risk of mortality compared to therapeutic AC (RR = 1.58, 95% CI 1.34; 1.87, p  0.001). CONCLUSION: Findings support the association of AC with mortality in Covid-19 patients. The results, synthesized from mostly low-quality studies, show that prophylactic and therapeutic AC might reduce mortality in Covid-19 patients. Findings suggest that therapeutic doses might be associated with better survival compared to prophylactic doses.
AD  - Clinical Pharmacy Department, College of Pharmacy, Cairo University, Cairo, Egypt.
AN  - 33022834
AU  - Kamel, A. M.
AU  - Sobhy, M.
AU  - Magdy, N.
AU  - Sabry, N.
AU  - Farid, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/rmv.2180
DP  - NLM
ET  - 2020/10/07
J2  - Reviews in medical virology
KW  - Covid-19
anticoagulants
meta-analysis
mortality
systematic review
thromboprophylaxis
LA  - eng
N1  - 1099-1654
Kamel, Ahmed M
Orcid: 0000-0002-3791-5998
Sobhy, Mona
Magdy, Nada
Sabry, Nirmeen
Farid, Samar
Journal Article
Review
England
Rev Med Virol. 2020 Oct 6:e2180. doi: 10.1002/rmv.2180.
PY  - 2020
SN  - 1052-9276
SP  - e2180
ST  - Anticoagulation outcomes in hospitalized Covid-19 patients: A systematic review and meta-analysis of case-control and cohort studies
T2  - Reviews in medical virology
TI  - Anticoagulation outcomes in hospitalized Covid-19 patients: A systematic review and meta-analysis of case-control and cohort studies
ID  - 7790938
ER  - 

TY  - JOUR
AU  - Kamal, Arif H.
AU  - Casarett, David J.
AU  - Meier, Diane E.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Compassion in a Crisis: The Role of Palliative Care During the COVID-19 Pandemic
T2  - Mayo Clinic Proceedings
TI  - Compassion in a Crisis: The Role of Palliative Care During the COVID-19 Pandemic
UR  - https://doi.org/10.1016/j.mayocp.2020.08.032
ID  - 7793103
ER  - 

TY  - JOUR
AB  - Letter to the Editor.
AN  - 33021757
AU  - Kahraman, F.
AU  - Özkara, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.3906/sag-2009-159
DP  - NLM
ET  - 2020/10/07
J2  - Turkish journal of medical sciences
KW  - Covid-19
Turkey
scientific research
transmission
LA  - eng
N1  - 1303-6165
Kahraman, Fatİh
Özkara, Adem
Journal Article
Turkey
Turk J Med Sci. 2020 Oct 6. doi: 10.3906/sag-2009-159.
PY  - 2020
SN  - 1300-0144
ST  - COVID-19 transmission sources, management, and scientific research in Turkey
T2  - Turkish journal of medical sciences
TI  - COVID-19 transmission sources, management, and scientific research in Turkey
ID  - 7791005
ER  - 

TY  - JOUR
AB  - The coronavirus COVID-19 is affecting 213 countries and territories around the world Iran was one of the first affected countries by this virus Isfahan, as the third most populated province of Iran, experienced a noticeable epidemic The prediction of epidemic size, peak value, and peak time can help policymakers in correct decisions In this study, deep learning is selected as a powerful tool for forecasting this epidemic in Isfahan A combination of effective Social Determinant of Health (SDH) and the occurrences of COVID-19 data are used as spatiotemporal input by using time-series information from different locations Different models are utilized, and the best performance is found to be for a tailored type of long short-term memory (LSTM) This new method incorporates mutual effect of all classes (confirmed/ death / recovered) in predication process The future trajectory of the outbreak in Isfahan is forecasted with the proposed model The paper demonstrates the positive effect of adding SDHs in pandemic prediction Furthermore, the effectiveness of different SDHs is discussed, and the most effective terms are introduced The method expresses high ability in both short- and long- term forecasting of the outbreak The model proves that in predicting one class (like the number of confirmed cases), the effect of other accompanying numbers (like death and recovered cases) cannot be ignored In conclusion, the superiorities of this model (particularity the long term predication ability) turn it into a reliable tool for helping the health decision makers
AU  - Kafieh, Rahele
AU  - Saeedizadeh, Narges
AU  - Arian, Roya
AU  - Amini, Zahra
AU  - Serej, Nasim Dadashi
AU  - Vaezi, Atefeh
AU  - Javanmard, Shaghayegh Haghjooy
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Isfahan and Covid-19: Deep Spatiotemporal Representation
T2  - Chaos, Solitons & Fractals
TI  - Isfahan and Covid-19: Deep Spatiotemporal Representation
UR  - https://doi.org/10.1016/j.chaos.2020.110339
ID  - 7793211
ER  - 

TY  - JOUR
AB  - Rationale and Objectives: Quantify changes in total and by-subspecialty radiology workload due to deferring non-urgent services during the initial COVID-19 pandemic, and describe operational strategies implemented due to shifts in priority Materials and Methods: This retrospective, Institutional Review Board-exempt, study was performed 2/3/2020-4/19/2020 at a large academic medical center During March 9-15 (intervention period), non-urgent outpatient service deferments began 5-week periods pre- (baseline) and post-intervention (COVID) were defined Primary outcomes were radiology volume (reports per day) overall and in eleven subspecialty divisions Linear regression assessed relationship between baseline vs COVID volumes stratified by division Secondary outcomes included changes in relative value units (RVUs), inpatient and outpatient volumes Results: There were 62,791 baseline reports vs 23,369 during COVID;a 60% overall precipitous volume decrease (p75% volume decrease Total RVUs decreased 60% (71,186 baseline;28,476 COVID) Both outpatient and inpatient report volumes decreased;72% (41,115 baseline;11,326 COVID) and 43% (12,626 baseline vs 6,845 COVID), respectively In labor pool tracking data, 21 8% (162/744) total radiology employees were reassigned to other hospital duties during the intervention period Conclusion: Precipitous radiology workload reductions impacted subspecialty divisions with marked variation Data-driven operational decisions during COVID-19 assisted workflow and staffing assignment changes Ongoing adjustments will be needed as healthcare systems transition operations to a ‘new normal�?
AU  - JunziShi, Giess
AU  - Catherine, S.
AU  - Martin, Tyler
AU  - Lemaire, Karen A.
AU  - Curley, Patrick J.
AU  - Bay, Camden
AU  - Mayo-Smith, William W.
AU  - Boland, Giles W.
AU  - Khorasani, Ramin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Radiology workload changes during the COVID-19 pandemic: implications for staff redeployment
T2  - Academic Radiology
TI  - Radiology workload changes during the COVID-19 pandemic: implications for staff redeployment
UR  - https://doi.org/10.1016/j.acra.2020.09.008
ID  - 7793260
ER  - 

TY  - JOUR
AB  - Despite its overwhelming clinical importance, the SARS-CoV-2 gene set remains unresolved, hindering dissection of COVID-19 biology. Here, we use comparative genomics to provide a high-confidence protein-coding gene set, characterize protein-level and nucleotide-level evolutionary constraint, and prioritize functional mutations from the ongoing COVID-19 pandemic. We select 44 complete Sarbecovirus genomes at evolutionary distances ideally-suited for protein-coding and non-coding element identification, create whole-genome alignments, and quantify protein-coding evolutionary signatures and overlapping constraint. We find strong protein-coding signatures for all named genes and for 3a, 6, 7a, 7b, 8, 9b, and also ORF3c, a novel alternate-frame gene. By contrast, ORF10, and overlapping-ORFs 9c, 3b, and 3d lack protein-coding signatures or convincing experimental evidence and are not protein-coding. Furthermore, we show no other protein-coding genes remain to be discovered. Cross-strain and within-strain evolutionary pressures largely agree at the gene, amino-acid, and nucleotide levels, with some notable exceptions, including fewer-than-expected mutations in nsp3 and Spike subunit S1, and more-than-expected mutations in Nucleocapsid. The latter also shows a cluster of amino-acid-changing variants in otherwise-conserved residues in a predicted B-cell epitope, which may indicate positive selection for immune avoidance. Several Spike-protein mutations, including D614G, which has been associated with increased transmission, disrupt otherwise-perfectly-conserved amino acids, and could be novel adaptations to human hosts. The resulting high-confidence gene set and evolutionary-history annotations provide valuable resources and insights on COVID-19 biology, mutations, and evolution.
AN  - 33024961
AU  - Jungreis, I.
AU  - Sealfon, R.
AU  - Kellis, M.
C1  - 10/7/2020
C2  - PMC7536840
DA  - Oct 1
DB  - PubMed
DO  - 10.21203/rs.3.rs-80345/v1
DP  - NLM
ET  - 2020/10/08
J2  - Research square
LA  - eng
N1  - Jungreis, Irwin
Orcid: 0000-0002-3197-5367
Sealfon, Rachel
Kellis, Manolis
Orcid: 0000-0001-7113-9630
Preprint
United States
Res Sq. 2020 Oct 1:rs.3.rs-80345. doi: 10.21203/rs.3.rs-80345/v1. Preprint.
PY  - 2020
ST  - SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
T2  - Research square
TI  - SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes
ID  - 7790753
ER  - 

TY  - JOUR
AB  - The combination of COVID-19 and the Fourth Industrial Revolution has brought an unprecedented new normal, which has affected all aspects of human life, including religious activities As a consequence, church mission and different ministries have found themselves more dependent on media Furthermore, the convergent digital technology continually develops augmented reality and virtual reality, in which churches are planted and continue to carry out their mission and ministries Although virtual reality churches are new mission frontiers in the digital age, there are several theological issues from the conventional perspective of church ministry and mission This paper aims to address the controversial theological issues and reflect on them from an ecclesiological perspective to explore a theological possibility to overcome the issues and to justify their mission and ministries in virtual reality
AU  - Jun, Guichun
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Virtual Reality Church as a New Mission Frontier in the Metaverse: Exploring Theological Controversies and Missional Potential of Virtual Reality Church
T2  - Transformation
TI  - Virtual Reality Church as a New Mission Frontier in the Metaverse: Exploring Theological Controversies and Missional Potential of Virtual Reality Church
UR  - https://doi.org/10.1177/0265378820963155
ID  - 7792836
ER  - 

TY  - JOUR
AB  - Background: American Indians (AIs) live with historical trauma, or the cumulative emotional and psychological wounding that is passed from one generation to the next in response to the loss of lives and culture Psychological consequences of historical trauma may contribute to health disparities Purpose: Here, we investigate whether historical trauma predicts changes in psychological stress associated with the onset of the COVID-19 pandemic in AI adults Based on the stress-sensitization theory, we hypothesize that greater historical trauma will predict greater increases in levels of psychological stress from before the onset of the pandemic to after Method: Our analytic sample consisted of 205 AI adults We measured historical trauma and levels of psychological stress before and after the onset of the pandemic Results: Using hierarchical regression models controlling for age, biological sex, income, symptoms of depression and anxiety, psychological stress at Time 1, COVID-19 specific stress, and childhood trauma, we found that greater historical trauma preceding the pandemic predicted greater increases in psychological stress (β�?�? 38, t�?�? 17 p�?amp;lt;�?01, ΔR2�?�? 12), and levels of social support interacted with historical trauma to predict changes in psychological stress (β�? −0 19, t�? −3 34, p�?�?001, ΔR2�?�? 04) The relationship between historical trauma and changes in stress was significant for individuals with low levels of social support Conclusions: Historical trauma may contribute to AI mental health disparities, through heightened psychological stress responses to life stressors and social support appears to moderate this relationship
AU  - John-Henderson, Neha A.
AU  - Ginty, Annie T.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Historical Trauma and social support as predictors of psychological stress responses in American Indian adults during the COVID-19 pandemic
T2  - Journal of Psychosomatic Research
TI  - Historical Trauma and social support as predictors of psychological stress responses in American Indian adults during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.jpsychores.2020.110263
ID  - 7793118
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 is responsible for COVID-19, resulting in the largest pandemic in over a hundred years. After examining the molecular structures and activities of hepatitis C viral inhibitors and comparing hepatitis C virus and coronavirus replication, we previously postulated that the FDA-approved hepatitis C drug EPCLUSA (Sofosbuvir/Velpatasvir) might inhibit SARS-CoV-2. We subsequently demonstrated that Sofosbuvir triphosphate is incorporated by the relatively low fidelity SARS-CoV and SARS-CoV-2 RNA-dependent RNA polymerases (RdRps), serving as an immediate polymerase reaction terminator, but not by a host-like high fidelity DNA polymerase. Other investigators have since demonstrated the ability of Sofosbuvir to inhibit SARS-CoV-2 replication in lung and brain cells; additionally, COVID-19 clinical trials with EPCLUSA and with Sofosbuvir plus Daclatasvir have been initiated in several countries. SARS-CoV-2 has an exonuclease-based proofreader to maintain the viral genome integrity. Any effective antiviral targeting the SARS-CoV-2 RdRp must display a certain level of resistance to this proofreading activity. We report here that Sofosbuvir terminated RNA resists removal by the exonuclease to a substantially higher extent than RNA terminated by Remdesivir, another drug being used as a COVID-19 therapeutic. These results offer a molecular basis supporting the current use of Sofosbuvir in combination with other drugs in COVID-19 clinical trials.
AD  - Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA.
Department of Chemistry, Columbia University, New York, NY, 10027, USA.
Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA.
Center for Genome Technology and Biomolecular Engineering, Columbia University, New York, NY, 10027, USA. dj222@columbia.edu.
Department of Chemical Engineering, Columbia University, New York, NY, 10027, USA. dj222@columbia.edu.
Department of Molecular Pharmacology and Therapeutics, Columbia University, New York, NY, 10032, USA. dj222@columbia.edu.
AN  - 33024223
AU  - Jockusch, S.
AU  - Tao, C.
AU  - Li, X.
AU  - Chien, M.
AU  - Kumar, S.
AU  - Morozova, I.
AU  - Kalachikov, S.
AU  - Russo, J. J.
AU  - Ju, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73641-9
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Jockusch, Steffen
Tao, Chuanjuan
Li, Xiaoxu
Chien, Minchen
Kumar, Shiv
Morozova, Irina
Kalachikov, Sergey
Russo, James J
Ju, Jingyue
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16577. doi: 10.1038/s41598-020-73641-9.
PY  - 2020
SN  - 2045-2322
SP  - 16577
ST  - Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir
T2  - Scientific reports
TI  - Sofosbuvir terminated RNA is more resistant to SARS-CoV-2 proofreader than RNA terminated by Remdesivir
VL  - 10
ID  - 7790832
ER  - 

TY  - JOUR
AB  - Importance. The addition of a serological testing could reduce the overall testing costs of a PCR-based SARS-CoV-2 testing reopening plan for colleges/universities in the United States, without compromising the efficacy of the testing plan. Objectives. To determine whether a college/university reopening SARS-CoV-2 testing plan that includes serological testing can be cost-saving compared to a PCR-only testing. Design, Setting, and Participants: We assessed costs of serological testing in addition to PCR testing under various scenarios of university sizes (2000, 10,000, and 40,000) and epidemic conditions (initial antibody prevalence 2.5-15%; cumulative SARS-CoV-2 incidence during the school year 5-30%) of SARS-CoV-2 in the United States. We estimated total testing costs and relative percentage of cost-savings of different screening (i.e. targeted/ universal) and testing (i.e. in-sourcing/out-sourcing) scenarios between September 2020-May 2021. Main Outcomes and Measures: Testing costs of serological testing and PCR testing, Relative percentage of cost saving by including serology testing in addition to PCR testing. Results: Including baseline serology testing alongside routine regular PCR testing can reduce total test volumes and related costs throughout the school year. While the total testing cost is likely much lower if regular PCR testing is insourced compared to outsourced ($5 million vs $34 million for university size 10,000), including serologic testing could achieve the up to 20% cost-savings relative to PCR testing alone. The insourcing of serological testing when PCR testing is insourced can achieve greater cost-savings under high initial antibody prevalence (&amp;gt;5%) and cumulative incidence throughout the school year (&amp;gt;10%) at medium and large sized universities. If PCR testing is outsourced, however, the inclusion of serological testing becomes always preferred in most university sizes and epidemic conditions. Conclusions and Relevance: While regular PCR testing alone is the preferred strategy for containing epidemics, including serology testing may help achieve cost-savings if outbreaks are anticipated, or if baseline seropositivity is high.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding support for this study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Neither ethical approval nor informed consent was required for this analysis which did not involve human subjects research.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData consisted of model output and parameters from existing literature. Data available upon request from corresponding author.
AU  - Jo, Youngji
AU  - Singh, Ruby
AU  - Rao, Gabriella
AU  - Galea, Sandro
AU  - Nichols, Brooke E.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206680
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206680
ST  - Serological testing in addition to PCR screening for the re-opening of American colleges and universities: potential for cost-savings without compromising pandemic mitigation (preprint)
T2  - medRxiv
TI  - Serological testing in addition to PCR screening for the re-opening of American colleges and universities: potential for cost-savings without compromising pandemic mitigation (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206680.abstract
ID  - 7794761
ER  - 

TY  - JOUR
AD  - Department of Endocrinology and Nutrition, University Hospital of La Princesa, Madrid, Spain.
Department of Endocrinology and Nutrition, Hospital Arnau de Vilanova, Valencia, Spain.
Department of Endocrinology and Nutrition, University Hospital of La Princesa, Madrid, Spain. monica.marazuela@salud.madrid.org.
AN  - 33025554
AU  - Jiménez-Blanco, S.
AU  - Pla-Peris, B.
AU  - Marazuela, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s40618-020-01440-0
DP  - NLM
ET  - 2020/10/08
J2  - Journal of endocrinological investigation
LA  - eng
N1  - 1720-8386
Jiménez-Blanco, S
Pla-Peris, B
Marazuela, M
Orcid: 0000-0002-6266-2961
Letter
Italy
J Endocrinol Invest. 2020 Oct 6. doi: 10.1007/s40618-020-01440-0.
PY  - 2020
SN  - 0391-4097
ST  - COVID-19: a cause of recurrent Graves' hyperthyroidism?
T2  - Journal of endocrinological investigation
TI  - COVID-19: a cause of recurrent Graves' hyperthyroidism?
ID  - 7790693
ER  - 

TY  - JOUR
AB  - Heat treatment denatures viral proteins that comprise the virion, making virus incapable of infecting a host. Coronavirus (CoV) virions contain single-stranded RNA genomes with a lipid envelope and 4 proteins, 3 of which are associated with the lipid envelope and thus are thought to be easily denatured by heat or surfactant-type chemicals. Prior studies have shown that a temperature of as low as 75 oC and treatment duration of 15 min can effectively inactivate CoV. The applicability of a CoV heat inactivation method greatly depends on the length of time of a heat treatment and the temperature needed to inactivate the virus. With the goal of finding conditions where sub-second heat exposure of CoV can sufficiently inactivate CoV, we designed and developed a simple system that can measure sub-second heat inactivation of CoV. The system is composed of capillary stainless-steel tubing immersed in a temperature-controlled oil bath followed by an ice bath, through which virus solution can be flowed at various speeds. Flowing virus solution at different speeds, along with a real-time temperature monitoring system, allows the virus to be accurately exposed to a desired temperature for various durations of time. Using mouse hepatitis virus (MHV), a beta-coronavirus, as a model system, we identified that 85.2 oC for 0.48 s exposure is sufficient to obtain &amp;gt; 5 Log10 reduction in viral titer (starting titer: 5 x 107 PFU/mL), and that when exposed to 83.4 oC for 0.95 s, the virus was completely inactivated (zero titer, &amp;gt; 6 Log10 reduction).
AU  - Jiang, Yuqian
AU  - Zhang, Han
AU  - Wippold, Jose A.
AU  - Gupta, Jyotsana
AU  - Dai, Jing
AU  - de Figueiredo, Paul
AU  - Leibowitz, Julian L.
AU  - Han, Arum
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.05.327528
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.05.327528
ST  - Sub-second heat inactivation of coronavirus (preprint)
T2  - bioRxiv
TI  - Sub-second heat inactivation of coronavirus (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.05.327528.abstract
ID  - 7794715
ER  - 

TY  - JOUR
AB  - This study examined the difficulties of running online physical education classes in the context of coronavirus disease 2019 (COVID-19) and used the findings to develop an efficient operation plan to address these difficulties Six middle and high school physical education teachers participated;three were experts in online physical education and active in the Korea Council School Physical Education Promotion, and three were recommended teachers making efforts to improve the online classes offered by the Korea Ministry of Education A qualitative case study method employing phenomenological procedures to collect and analyze the data was used The difficulties of operating middle and high school online physical education classes for the first time included (1) the monotony of the classes within their limited environmental conditions and limited educational content that did not adequately convey the value of physical education, (2) trial-and-error methods applied nationwide, resulting from a lack of expertise in operating online physical education classes, and (3) very limited evaluation guidelines proposed by the Korea Ministry of Education, which made systematic evaluation with online methods impossible To address the identified problems and facilitate the efficient operation of online physical education classes, changes in strategic learning methods are needed to understand online physical education characteristics and thereby better communicate the value of physical education It is also necessary to cultivate teaching expertise through sharing online physical education classes, where collaboration among physical education teachers is central In addition, evaluation processes should be less formal to encourage active student participation
AU  - Jeong, Hyun-Chul
AU  - So, Wi-Young
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Difficulties of Online Physical Education Classes in Middle and High School and an Efficient Operation Plan to Address Them
T2  - International Journal of Environmental Research and Public Health
TI  - Difficulties of Online Physical Education Classes in Middle and High School and an Efficient Operation Plan to Address Them
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813217
ID  - 7793355
ER  - 

TY  - GEN
AB  - I analyze a simplified SIR model developed from a paper written by Gyan Bhanot and Charles de Lisi in May of 2020 to find the successes and limitations of their predictions. In particular, I study the predicted cases and deaths fitted to data from March and its potential application to data in September. The data is observed to fit the model as predicted until around 150 days after December 31, 2019, after which many countries lift their lockdowns and begin to reopen. A plateau in cases followed by an increase approximately 1.5 months after is also observed. In terms of deaths, the data fits the shape of the model, but the model mostly underestimates the death toll after around 160 days. An analysis of the residuals is provided to locate the precise date of the departure of each country from its accepted data estimates and test each data point to its predicted value using a Z-test to determine whether each observation can fit the given model. The observed behavior is matched to policy measures taken in each country to attach an explanation to these observations. I notice that an international reopening results in a sharp increase in cases, and aim to plot this new growth in cases and predict when the pandemic will end for each country.
AU  - Jay, Patwardhan
C1  - 10/7/2020
DB  - PREPRINT-MEDRXIV
DO  - 10.1101/2020.10.03.20206359
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
ST  - PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL
TI  - PREDICTIONS FOR EUROPE FOR THE COVID-19 PANDEMICAFTER LOCKDOWN WAS LIFTED USING AN SIR MODEL
UR  - https://medrxiv.org/cgi/content/short/2020.10.03.20206359
ID  - 7793418
ER  - 

TY  - JOUR
AU  - Jaumdally, Hannah
AU  - Salih, Marwah
AU  - Jabir, Ahmed A. L.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Commentary on ‘inimical effects of COVID-19 on surgical residency: Correspondence�?
T2  - Annals of Medicine and Surgery
TI  - Commentary on ‘inimical effects of COVID-19 on surgical residency: Correspondence�?
UR  - https://doi.org/10.1016/j.amsu.2020.09.039
ID  - 7793245
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (Covid-19), caused by SARS-CoV-2, exerts far-reaching effects on public health and socioeconomic welfare. The majority of infected individuals have mild to moderate symptoms but a significant proportion develops respiratory failure due to pneumonia. Thrombosis is another frequent manifestation of Covid-19 that contributes to poor outcomes. Vitamin K plays a crucial role in activation of both pro- and anticlotting factors in the liver, and the activation of extrahepatically synthesised protein S which seems to be important in local thrombosis prevention. However, the role of vitamin K extends beyond coagulation. Matrix Gla protein (MGP) is a vitamin K-dependent inhibitor of soft tissue calcification and elastic fibre degradation. Severe extrahepatic vitamin K insufficiency was recently demonstrated in Covid-19 patients, with high inactive MGP levels correlating with elastic fibre degradation rates. This suggests that insufficient vitamin K-dependent MGP activation leaves elastic fibres unprotected against SARS-CoV-2 induced proteolysis. In contrast to MGP, Covid-19 patients have normal levels of activated factor II, in line with previous observations that vitamin K is preferentially transported to the liver for activation of procoagulant factors. We therefore expect that vitamin K-dependent endothelial protein S activation is also compromised, which would be compatible with enhanced thrombogenicity. Taking these data together, we propose a mechanism of pneumonia-induced vitamin K depletion, leading to a decrease in activated MGP and protein S, aggravating pulmonary damage and coagulopathy, respectively. Intervention trials should be conducted to assess whether vitamin K administration plays a role in prevention and treatment of severe Covid-19.
AD  - Department of Pulmonary Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Department of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
Department of Respiratory Diseases, University Hospitals Leuven, Belgium.
AN  - 33023681
AU  - Janssen, R.
AU  - Visser, M. P. J.
AU  - Dofferhoff, A. S. M.
AU  - Vermeer, C.
AU  - Janssens, W.
AU  - Walk, J.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1017/s0007114520003979
DP  - NLM
ET  - 2020/10/08
J2  - The British journal of nutrition
LA  - eng
N1  - 1475-2662
Janssen, Rob
Orcid: 0000-0001-9085-3194
Visser, Margot P J
Dofferhoff, Anton S M
Vermeer, Cees
Janssens, Wim
Walk, Jona
Journal Article
England
Br J Nutr. 2020 Oct 7:1-25. doi: 10.1017/S0007114520003979.
PY  - 2020
SN  - 0007-1145
SP  - 1-25
ST  - Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Covid-19
T2  - British journal of nutrition
TI  - Vitamin K metabolism as the potential missing link between lung damage and thromboembolism in Covid-19
ID  - 7790888
ER  - 

TY  - JOUR
AB  - OBJECTIVES: Primary objectives �?To assess the time from randomisation until an improvement within 84 days defined as two points on a seven point ordinal scale or live discharge from the hospital in high-risk patients (group 1 to group 4) with SARS-CoV-2 infection requiring hospital admission by infusion of plasma from subjects after convalescence of SARS-CoV-2 infection or standard of care. Secondary objectives �?To assess overall survival, and the overall survival rate at 28 56 and 84 days. �?To assess SARS-CoV-2 viral clearance and load as well as antibody titres. �?To assess the percentage of patients that required mechanical ventilation. �?To assess time from randomisation until discharge. TRIAL DESIGN: Randomised, open-label, multicenter phase II trial, designed to assess the clinical outcome of SARS-CoV-2 disease in high-risk patients (group 1 to group 4) following treatment with anti-SARS-CoV-2 convalescent plasma or standard of care. PARTICIPANTS: High-risk patients 18 years of age hospitalized with SARS-CoV-2 infection in 10-15 university medical centres will be included. High-risk is defined as SARS-CoV-2 positive infection with Oxygen saturation at �?94% at ambient air with additional risk features as categorised in 4 groups: �?Group 1, pre-existing or concurrent hematological malignancy and/or active cancer therapy (incl. chemotherapy, radiotherapy, surgery) within the last 24 months or less. �?Group 2, chronic immunosuppression not meeting the criteria of group 1. �?Group 3, age �?50 - 75 years meeting neither the criteria of group 1 nor group 2 and at least one of these criteria: Lymphopenia  0.8 x G/l and/or D-dimer  1μg/mL. �?Group 4, age �?75 years meeting neither the criteria of group 1 nor group 2. Observation time for all patients is expected to be at least 3 months after entry into the study. Patients receive convalescent plasma for two days (day 1 and day 2) or standard of care. For patients in the standard arm, cross over is allowed from day 10 in case of not improving or worsening clinical condition. Nose/throat swabs for determination of viral load are collected at day 0 and day 1 (before first CP administration) and subsequently at day 2, 3, 5, 7, 10, 14, 28 or until discharge. Serum for SARS-Cov-2 diagnostic is collected at baseline and subsequently at day 3, 7, 14 and once during the follow-up period (between day 35 and day 84). There is a regular follow-up of 3 months. All discharged patients are followed by regular phone calls. All visits, time points and study assessments are summarized in the Trial Schedule (see full protocol Table 1). All participating trial sites will be supplied with study specific visit worksheets that list all assessments and procedures to be completed at each visit. All findings including clinical and laboratory data are documented by the investigator or an authorized member of the study team in the patient's medical record and in the electronic case report forms (eCRFs). INTERVENTION AND COMPARATOR: This trial will analyze the effects of convalescent plasma from recovered subjects with SARS-CoV-2 antibodies in high-risk patients with SARS-CoV-2 infection. Patients at high risk for a poor outcome due to underlying disease, age or condition as listed above are eligible for enrollment. In addition, eligible patients have a confirmed SARS-CoV-2 infection and O(2) saturation �?94% while breathing ambient air. Patients are randomised to receive (experimental arm) or not receive (standard arm) convalescent plasma in two bags (238 - 337 ml plasma each) from different donors (day 1, day 2). A cross over from the standard arm into the experimental arm is possible after day 10 in case of not improving or worsening clinical condition. MAIN OUTCOMES: Primary endpoints: The main purpose of the study is to assess the time from randomisation until an improvement within 84 days defined as two points on a seven-point ordinal scale or live discharge from the hospital in high-risk patients (group 1 to group 4) with SARS-CoV-2 infection requiring hospital admission by infusion of plasma from subjects after convalescence of a SARS-CoV-2 infection or standard of care. Secondary endpoints: �?Overall survival, defined as the time from randomisation until death from any cause 28-day, 56-day and 84-day overall survival rates. �?SARS-CoV-2 viral clearance and load as well as antibody titres. �?Requirement mechanical ventilation at any time during hospital stay (yes/no). �?Time until discharge from randomisation. �?Viral load, changes in antibody titers and cytokine profiles are analysed in an exploratory manner using paired non-parametric tests (before - after treatment). RANDOMISATION: Upon confirmation of eligibility (patients must meet all inclusion criteria and must not meet exclusion criteria described in section 5.3 and 5.4 of the full protocol), the clinical site must contact a centralized internet randomization system ( https://randomizer.at/ ). Patients are randomized using block randomisation to one of the two arms, experimental arm or standard arm, in a 1:1 ratio considering a stratification according to the 4 risk groups (see Participants). BLINDING (MASKING): The study is open-label, no blinding will be performed. NUMBERS TO BE RANDOMISED (SAMPLE SIZE): A total number of 174 patients is required for the entire trial, n=87 per group. TRIAL STATUS: Protocol version 1.2 dated 09/07/2020. A recruitment period of approximately 9 months and an overall study duration of approximately 12 months is anticipated. Recruitment of patients starts in the third quarter of 2020. The study duration of an individual patient is planned to be 3 months. After finishing all study-relevant procedures, therapy, and follow-up period, the patient is followed in terms of routine care and treated if necessary. Total trial duration: 18 months Duration of the clinical phase: 12 months First patient first visit (FPFV): 3(rd) Quarter 2020 Last patient first visit (LPFV): 2(nd) Quarter 2021 Last patient last visit (LPLV): 3(rd) Quarter 2021 Trial Report completed: 4(th) Quarter 2021 TRIAL REGISTRATION: EudraCT Number: 2020-001632-10, https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001632-10/DE , registered on 04/04/2020. FULL PROTOCOL: The full protocol is attached as an additional file, accessible from the Trials website (Additional file 1). In the interest in expediting dissemination of this material, the familiar formatting has been eliminated; this Letter serves as a summary of the key elements of the full protocol. The study protocol has been reported in accordance with the Standard Protocol Items: Recommendations for Clinical Interventional Trials (SPIRIT) guidelines (Additional file 2). The eCRF is attached (Additional file 3).
AD  - Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany. maike.janssen@med.uni-heidelberg.de.
Department of Internal Medicine V, Heidelberg University Hospital, Heidelberg, Germany.
NCT-Trial Center, National Center of Tumor Diseases, Heidelberg University Hospital and German Cancer Research Center, Heidelberg, Germany.
Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Division of Tropical Medicine, Department of Infectious Diseases, Heidelberg University Hospital, Heidelberg, Germany.
Division of Infectious Diseases, University Hospital Frankfurt, Frankfurt, Germany.
University Hospital Dresden, Dresden, Germany.
Charité University Medicine, Berlin, Germany.
Department of Infectious Diseases, Molecular Virology, Heidelberg University Hospital, Heidelberg, Germany.
Department of Infectious Diseases, Virology, Heidelberg University Hospital, Heidelberg, Germany.
Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany.
Institute for Clinical Transfusion Medicine and Cell Therapy Heidelberg, Heidelberg, Germany.
Department of Anaesthesiology, Heidelberg University Hospital, Heidelberg, Germany.
Department of Internal Medicine IV, Heidelberg University Hospital, Heidelberg, Germany.
AN  - 33023671
AU  - Janssen, M.
AU  - Schäkel, U.
AU  - Djuka Fokou, C.
AU  - Krisam, J.
AU  - Stermann, J.
AU  - Kriegsmann, K.
AU  - Haberbosch, I.
AU  - Novotny, J. P.
AU  - Weber, S.
AU  - Vehreschild, M.
AU  - Bornhäuser, M.
AU  - Bullinger, L.
AU  - Schmitt, M.
AU  - Liebregts, T.
AU  - Dreger, P.
AU  - Lorenz, H. M.
AU  - Plaszczyca, A.
AU  - Bartenschlager, R.
AU  - Müller, B.
AU  - Kräusslich, H. G.
AU  - Halama, N.
AU  - Jäger, D.
AU  - Schlenk, R. F.
AU  - Leo, A.
AU  - Meuer, S.
AU  - Weigand, M. A.
AU  - Motsch, J.
AU  - Merle, U.
AU  - Denkinger, C. M.
AU  - Müller-Tidow, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13063-020-04735-y
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Trials
KW  - Covid-19
Randomised controlled trial
convalescent plasma
early application
high-risk patients with severe disease
protocol
LA  - eng
N1  - 1745-6215
Janssen, Maike
Schäkel, Ulrike
Djuka Fokou, Carine
Krisam, Johannes
Stermann, Jacek
Kriegsmann, Katharina
Haberbosch, Isabella
Novotny, Jan Philipp
Weber, Stefan
Vehreschild, Maria
Bornhäuser, Martin
Bullinger, Lars
Schmitt, Michael
Liebregts, Tobias
Dreger, Peter
Lorenz, Hanns-Martin
Plaszczyca, Anna
Bartenschlager, Ralf
Müller, Barbara
Kräusslich, Hans-Georg
Halama, Niels
Jäger, Dirk
Schlenk, Richard F
Leo, Albrecht
Meuer, Stefan
Weigand, Markus A
Motsch, Johann
Merle, Uta
Denkinger, Claudia M
Müller-Tidow, Carsten
01ki20152/bmbf/
Letter
England
Trials. 2020 Oct 6;21(1):828. doi: 10.1186/s13063-020-04735-y.
PY  - 2020
SN  - 1745-6215
SP  - 828
ST  - A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial
T2  - Trials
TI  - A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease (RECOVER): A structured summary of a study protocol for a randomised controlled trial
VL  - 21
ID  - 7790890
ER  - 

TY  - JOUR
AU  - Ishmatov, Alexander
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - airborne transmission
air pollution
SARS-CoV-2
COVID-19
aerosol
PY  - 2020
ST  - Virus-Laden Particles and Particulate Matter (Air Pollutants) with Viruses Attached: Terminology Matters �?Short Report. How Rumors that Air Pollutants Spread SARS-CoV-2 Are Born (preprint)
T2  - SSRN
TI  - Virus-Laden Particles and Particulate Matter (Air Pollutants) with Viruses Attached: Terminology Matters �?Short Report. How Rumors that Air Pollutants Spread SARS-CoV-2 Are Born (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3703004
ID  - 7794792
ER  - 

TY  - JOUR
AB  - Immediately post-production, commercially available bioshell calcium oxide (BiSCaO) water is colorless, transparent, and strongly alkaline (pH 12 8), and is known to possess deodorizing properties and broad microbicidal activity However, BiSCaO Water may represent a serious safety risk to the living body, given the strong alkalinity This study aimed to investigate the safety of BiSCaO Water for use as an antiseptic/disinfectant despite concerns regarding its high alkalinity The change over time in pH of BiSCaO Water was measured during air contact (stirring BiSCaO Water in ambient air) When sprayed on metal, plastic, wood piece, paper, and skin surfaces, the pH of BiSCaO Water decreased rapidly, providing a white powder coating upon drying Scanning electron microscopy images, energy dispersive X-ray elemental mapping, and X-ray diffractograms showed that the dried powder residues of BiSCaO Water were composed primarily of calcium carbonate These results suggested that BiSCaO Water is a potent reagent that may overcome the obstacles of being strongly alkaline, making this material appropriate for use in disinfection against pathogenic microbes
AU  - Ishihara, Masayuki
AU  - Hata, Yuuki
AU  - Hiruma, Sumiyo
AU  - Takayama, Tomohiro
AU  - Nakamura, Shingo
AU  - Sato, Yoko
AU  - Ando, Naoko
AU  - Fukuda, Koichi
AU  - Murakami, Kaoru
AU  - Yokoe, Hidetaka
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Safety of Concentrated Bioshell Calcium Oxide Water Application for Surface and Skin Disinfections against Pathogenic Microbes
T2  - Molecules
TI  - Safety of Concentrated Bioshell Calcium Oxide Water Application for Surface and Skin Disinfections against Pathogenic Microbes
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-814954
ID  - 7792690
ER  - 

TY  - JOUR
AD  - Infectious Diseases & Clinical Ethics, Children's Hospital at Westmead, Sydney, New South Wales, Australia.
Clinical Ethics, Sydney Children's Hospital Network, Sydney, New South Wales, Australia.
AN  - 33025660
AU  - Isaacs, D.
AU  - Priesz, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/jpc.15164
DP  - NLM
ET  - 2020/10/08
J2  - Journal of paediatrics and child health
LA  - eng
N1  - 1440-1754
Isaacs, David
Orcid: 0000-0002-9593-7378
Priesz, Anne
Orcid: 0000-0003-4331-1434
Editorial
Australia
J Paediatr Child Health. 2020 Oct 6. doi: 10.1111/jpc.15164.
PY  - 2020
SN  - 1034-4810
ST  - COVID-19 and the metaphor of war
T2  - Journal of paediatrics and child health
TI  - COVID-19 and the metaphor of war
ID  - 7790689
ER  - 

TY  - JOUR
AB  - Big Data occupies an important place in the prediction of diseases that happen due to climate change In each aspect of human life, the weather plays a major role It directly affects human society or human life Because of an extreme weather condition creates various diseases among humans Such as Vector-borne diseases (Malaria, dengue and chikungunya fever), Water-borne diseases (Cholera, Typhoid), Air-borne diseases (Chicken Pox, influenza and small Pox) and Food-borne diseases (Diarrhoea and Salmonella) etc This survey presents an overview for a climate variable such as extreme temperature, precipitation, humidity and how unexpected climate conditions can affect the disease and living organism
AU  - Indhumathi, K.
AU  - Sathesh Kumar, K.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A review on prediction of seasonal diseases based on climate change using big data
T2  - Materials Today: Proceedings
TI  - A review on prediction of seasonal diseases based on climate change using big data
UR  - https://doi.org/10.1016/j.matpr.2020.08.517
ID  - 7792688
ER  - 

TY  - JOUR
AB  - Some coronavirus disease 2019 (COVID-19) patients develop rapidly progressive acute respiratory distress syndrome and require veno-venous extracorporeal membrane oxygenation (VV ECMO) A previous study recommended the transfer of ECMO patients to ECMO centers However, because of the pandemic, a limited number of ECMO centers are available for patient transfer The safe long-distance interhospital transport of these patients is a concern To minimize transportation time, helicopter use is a suitable choice We report the first case of a COVID-19 patient on VV ECMO, transferred to our ECMO center by helicopter A 45-year-old man with rheumatoid arthritis history, treated with immunosuppressants, presented with fever and sore throat He was diagnosed with COVID-19 following a positive severe acute respiratory syndrome coronavirus 2 polymerase chain reaction test result and was subsequently prescribed favipiravir However, his respiratory failure progressively worsened On day 10 of hospitalization at the previous hospital, he was intubated, and we received a request for ECMO transport on the next day The ECMO team, who wore personal protective equipment (N95 respirators, gloves, gowns, and face shields), initiated VV ECMO in the referring hospital and safely transported the patient by helicopter The flight time was 7 min He was admitted to the intensive care unit of our hospital and received tocilizumab He was discharged on hospital day 31 with no significant sequelae In this case report, we discuss important factors for the safe and appropriate interhospital transportation of COVID-19 patients on ECMO as well as staff and patient safety during helicopter transportation
AU  - Imaeda, Taro
AU  - Hattori, Noriyuki
AU  - Abe, Ryuzo
AU  - Iwase, Shinya
AU  - Saito, Daiki
AU  - Koizumi, Kazuhisa
AU  - Chaisirin, Wansiri
AU  - Taniguchi, Toshibumi
AU  - Nakada, Taka-aki
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Interhospital transportation of a COVID-19 patient undergoing veno-venous extracorporeal membrane oxygenation by helicopter
T2  - American Journal of Emergency Medicine
TI  - Interhospital transportation of a COVID-19 patient undergoing veno-venous extracorporeal membrane oxygenation by helicopter
UR  - https://doi.org/10.1016/j.ajem.2020.09.089
ID  - 7793253
ER  - 

TY  - JOUR
AD  - Arrhythmology Department, Maria Cecilia Hospital, Cotignola (RA), Italy.
Clinical research, BIOTRONIK Italia S.p.a., Vimodrone (MI), Italy.
AN  - 33021400
AU  - Iacopino, S.
AU  - Placentino, F.
AU  - Colella, J.
AU  - Pesce, F.
AU  - Pardeo, A.
AU  - Filannino, P.
AU  - Artale, P.
AU  - Desiro, D.
AU  - Sorrenti, P.
AU  - Campagna, G.
AU  - Fabiano, G.
AU  - Peluso, G.
AU  - Giacopelli, D.
AU  - Petretta, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1161/circep.120.009040
DP  - NLM
ET  - 2020/10/07
J2  - Circulation. Arrhythmia and electrophysiology
LA  - eng
N1  - 1941-3084
Iacopino, Saverio
Placentino, Filippo
Colella, Jacopo
Pesce, Francesca
Pardeo, Antonino
Filannino, Pasquale
Artale, Paolo
Desiro, Dalila
Sorrenti, Paolo
Campagna, Giuseppe
Fabiano, Gennaro
Peluso, Gianluca
Giacopelli, Daniele
Petretta, Andrea
Journal Article
United States
Circ Arrhythm Electrophysiol. 2020 Oct 6. doi: 10.1161/CIRCEP.120.009040.
PY  - 2020
SN  - 1941-3084
ST  - New-onset Cardiac Arrhythmias during COVID-19 Hospitalization
T2  - Circulation Arrhythmia and electrophysiology
TI  - New-onset Cardiac Arrhythmias during COVID-19 Hospitalization
ID  - 7791032
ER  - 

TY  - JOUR
AB  - BACKGROUND: The global rate of intensive care unit (ICU) admission during the COVID-19 pandemic varies within countries and is among the main challenges for health care systems worldwide. Conflicting results have been reported about the response to coronavirus infection and COVID-19 outcomes in men and women. Understanding predictors of intensive care unit admission might be of help for future planning and management of the disease. METHODS AND FINDINGS: We designed a cross-sectional observational multicenter nationwide survey in Italy to understand gender-related clinical predictors of ICU admission in patients with COVID-19. We analyzed information from 2378 charts of Italian patients certified for COVID-19 admitted in 26 hospitals. Three hundred ninety-five patients (16.6%) required ICU admission due to COVID19 infection, more frequently men (74%), with a higher prevalence of comorbidities (1,78�u0,06 vs 1,54�u0,03 p0.05). In multivariable regression model main predictors of admission to ICU are male gender (OR 1,74 95% CI 1,36-2,22 p0.0001) and presence of obesity (OR 2,88 95% CI 2,03-4,07 p0.0001), chronic kidney disease (OR: 1,588; 95%, 1,036-2,434 p0,05) and hypertension (OR: 1,314; 95% 1,039-1,662; p0,05). In gender specific analysis, obesity, chronic kidney disease and hypertension are associated with higher rate of admission to ICU among men, whereas in women, obesity (OR: 2,564; 95% CI 1,336-4.920 p0.0001) and heart failure (OR: 1,775 95% CI: 1,030-3,057) are associated with higher rate of ICU admission. CONCLUSIONS: Our study demonstrates that gender is the primary determinant of the disease's severity among COVID-19. Obesity is the condition more often observed among those admitted to ICU within both genders. TRIAL REGISTRATION: Clinicaltrials.gov: NCT04331574.
AD  - Dept. of Advanced Biomedical Sciences, Federico II University, Naples, Italy.
Department of Medicine and Surgery, University of Milano-Bicocca, Milano, Italy.
Dept. of Medicine and Surgery Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Università degli Studi di Milano, Milano, Italy.
Clinica Medica 3, Department of Medicine (DIMED), University of Padova, Padova, Italy.
Dept. of Clinical Medicine, Public Health, Life and Environment Sciences, University of L'Aquila, L'Aquila, Italy.
Cardiology 4, "A. De Gasperis" Department, ASST GOM Niguarda Ca' Granda Hospital, Milan, Italy.
Department of Translational and Precision Medicine, Unit of Secondary Arterial Hypertension, Policlinico "Umberto I", "Sapienza" University of Rome, Rome, Italy.
Department of Medicine, Section of Internal Medicine C, University of Verona, Verona, Italy.
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Section of Internal Medicine Terni, Department of Medicine, University of Perugia, Terni, Italy.
Department of Clinical and Experimental Sciences, University of Brescia-Internal Medicine ASST Spedali Civili PO Montichiari, Brescia, Italy.
Dept. of Clinical & Experimental Sciences, Medicina 2, ASST Spedali Civili Brescia, University of Brescia, Brescia, Italy.
Internal Medicine and Geriatrics, Department of Clinical and Molecular Sciences, Italian National Research Centre on Aging, Hospital "U. Sestilli", IRCCS-INRCA, University "Politecnica Delle Marche", Ancona, Italy.
Department of Medicine, University of Udine, Udine, Italy.
Division of Internal Medicine and Hypertension, Department of Medical Sciences, University of Turin, Turin, Italy.
Clinical and Molecular Medicine Department, Rome and IRCCS Neuromed, Sapienza University Sant'Andrea Hospital, Pozzilli (IS), Italy.
AN  - 33022004
AU  - Iaccarino, G.
AU  - Grassi, G.
AU  - Borghi, C.
AU  - Carugo, S.
AU  - Fallo, F.
AU  - Ferri, C.
AU  - Giannattasio, C.
AU  - Grassi, D.
AU  - Letizia, C.
AU  - Mancusi, C.
AU  - Minuz, P.
AU  - Perlini, S.
AU  - Pucci, G.
AU  - Rizzoni, D.
AU  - Salvetti, M.
AU  - Sarzani, R.
AU  - Sechi, L.
AU  - Veglio, F.
AU  - Volpe, M.
AU  - Muiesan, M. L.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0237297
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Iaccarino, Guido
Orcid: 0000-0002-8997-835x
Grassi, Guido
Borghi, Claudio
Carugo, Stefano
Fallo, Francesco
Ferri, Claudio
Giannattasio, Cristina
Grassi, Davide
Letizia, Claudio
Mancusi, Costantino
Minuz, Pietro
Perlini, Stefano
Pucci, Giacomo
Rizzoni, Damiano
Salvetti, Massimo
Sarzani, Riccardo
Sechi, Leonardo
Veglio, Franco
Volpe, Massimo
Muiesan, Maria Lorenza
Orcid: 0000-0002-4007-9441
SARS-RAS Investigators
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0237297. doi: 10.1371/journal.pone.0237297. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0237297
ST  - Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension
T2  - PloS one
TI  - Gender differences in predictors of intensive care units admission among COVID-19 patients: The results of the SARS-RAS study of the Italian Society of Hypertension
VL  - 15
ID  - 7790992
ER  - 

TY  - JOUR
AB  - Critically ill patients with COVID-19 infection frequently exhibit a hyperinflammatory response and develop organ failures, however the underlying mechanisms are unclear. We investigated the microcirculatory, endothelial and inflammatory responses in critically ill COVID-19 patients and compared them to a group of patients with septic shock in a prospective observational case control study. 30 critically ill patients with COVID-19 were compared to 33 patients with septic shock.Measurements of sublingual microcirculatory flow using Incident Dark Field (IDF) video-microscopy and serial measurements of IL-6 and Syndecan-1 levels were performed. COVID-19 patients had significantly less vasoactive drug requirement and lower plasma lactate than those with septic shock. Microcirculatory flow was significantly worse in septic patients than those with COVID-19 (MFI 2.6 v 2.9 p 0.02, PPV 88 v 97% p �?.001). IL-6 was higher in patients with septic shock than COVID-19 (1653 v 253 pg/ml, p 0.03). IL-6 levels in COVID 19 patients were not elevated compared to healthy controls except on the day of ICU admission. Syndecan-1 levels were not different between the 2 pathological groups. Compared to patients with undifferentiated septic shock an overt shock state with tissue hypoperfusion does not appear typical of COVID-19 infection. There was no evidence of significant sublingual microcirculatory impairment, widespread endothelial injury or marked inflammatory cytokine release in this group of critically ill COVID-19 patients.
AD  - Department of Inflammation Biology, School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King's College London.
Department of Military Anaesthesia and Critical Care, Royal Centre for Defence Medicine, UK.
Institute of Liver Studies, King's College Hospital, London.
Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College, London.
AN  - 33021572
AU  - Hutchings, S. D.
AU  - Watchorn, J.
AU  - Trovato, F.
AU  - Napoli, S.
AU  - Mujib, S. F.
AU  - Hopkins, P.
AU  - McPhail, M.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1097/shk.0000000000001672
DP  - NLM
ET  - 2020/10/07
J2  - Shock (Augusta, Ga.)
LA  - eng
N1  - 1540-0514
Hutchings, Sam D
Watchorn, James
Trovato, Francesca
Napoli, Salvatore
Mujib, Salma F
Hopkins, Philip
McPhail, Mark
Journal Article
United States
Shock. 2020 Oct 5. doi: 10.1097/SHK.0000000000001672.
PY  - 2020
SN  - 1073-2322
ST  - Microcirculatory, Endothelial and Inflammatory Responses in Critically Ill Patients with COVID-19 are Distinct from those Seen in Septic Shock: A Case Control Study
T2  - Shock (Augusta, Ga)
TI  - Microcirculatory, Endothelial and Inflammatory Responses in Critically Ill Patients with COVID-19 are Distinct from those Seen in Septic Shock: A Case Control Study
ID  - 7791020
ER  - 

TY  - JOUR
AB  - The novel human coronavirus-2 (HCoV-2), called SARS-CoV-2, is the causative agent of Coronavirus Induced Disease (COVID-19) and has spread causing a global pandemic. Currently, there is no vaccine to prevent infection nor any approved drug for the treatment. The development of a new drug is time-consuming and cannot be relied on as a solution in combatting the immediate global challenge. In such a situation, the drug repurposing becomes an attractive solution to identify the potential of COVID-19 treatment by existing drugs, which are approved for other indications. Here, we review the potential use of rapamycin, an mTOR (Mammalian Target of Rapamycin) inhibitor that can be repurposed at low dosages for the treatment of COVID-19. Rapamycin inhibits protein synthesis, delays aging, reduces obesity in animal models, and inhibits activities or expression of pro-inflammatory cytokines such as IL-2, IL-6 and, IL-10. Overall, the use of rapamycin can help to control viral particle synthesis, cytokine storms and contributes to fight the disease by its anti-aging and anti-obesity effects. Since, rapamycin targets the host factors and not viral machinery, it represents a potent candidate for the treatment of COVID-19 than antiviral drugs as its efficacy is less likely to be dampened with high mutation rate of viral RNA. Additionally, the inhibitory effect of rapamycin on cell proliferation may aid in reducing viral replication. Therefore, by drug repurposing, low dosages of rapamycin can be tested for the potential treatment of COVID-19/SARS-CoV-2 infection.
AN  - PMC7536130
AU  - Husain, Amjad
AU  - Byrareddy, Siddappa N.
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.cbi.2020.109282
DP  - NLM
J2  - Chem Biol Interact
KW  - HCoV-2
COVID-19
SARS-CoV-2
Drug repurposing
Rapamycin
mTOR
LA  - eng
N1  - PMC7536130[pmcid]
S0009-2797(20)31053-X[PII]
PY  - 2020
SN  - 0009-2797
1872-7786
SP  - 109282
ST  - Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19
T2  - Chemico-Biological Interactions
TI  - Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536130/
ID  - 7790662
ER  - 

TY  - JOUR
AB  - Behavior courses face numerous challenges when moving to an online environment, as has been made necessary by the COVID-19 pandemic These challenges occur largely because behavior courses, like most organismal biology courses, often stress experiential learning through laboratories that involve live animals, as well as a lecture component that emphasizes formative assessment, discussion, and critical thinking Although online behavior courses may be remote, they can still be interactive and social, and designed with inclusive pedagogy Here, we discuss some of the key decisions that instructors should consider, provide recommendations, and point out new opportunities for student learning that stem directly from the move to online instruction Specific topics include challenges related to generating an inclusive and engaging online learning environment, synchronous versus asynchronous formats, assignments that enhance student learning, testing format and execution, grade schemes, design of laboratory experiences including opportunities for community science, design of synthetic student projects, and workload balance for students and instructors We designed this primer both for animal behavior instructors who need to quickly transition to online teaching in the midst of a pandemic, and for those facing such transitions in upcoming terms Much of the manuscript&#039;s content should also be of general interest and value to instructors from all areas of organismal biology who are attempting to quickly transition to online teaching
AU  - Hughes, Melissa
AU  - Bertram, Susan M.
AU  - Young, Anna M.
AU  - Merry, Justin W.
AU  - Kolluru, Gita R.
AU  - Dunlap, Aimee S.
AU  - Danielson-Francois, Anne
AU  - Weiss, Stacey
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Teaching animal behavior online: A primer for the pandemic and beyond
T2  - Ethology
TI  - Teaching animal behavior online: A primer for the pandemic and beyond
UR  - https://doi.org/10.1111/eth.13096
ID  - 7792876
ER  - 

TY  - JOUR
AB  - Initial reports have suggested that COVID-19 SARS 2 virus is more prevalent and is associated with increased severity in people with diabetes.(1) In a recent large series from the USA, diabetes mellitus was present as a comorbidity in over a third of patients hospitalized with COVID-19.(2) In a study of 658 hospitalized patients with confirmed COVID-19, three developed diabetic ketoacidosis (DKA).(3) Clinical experience during the COVID-19 crisis suggests that DKA and hyperglycaemic hyperosmolar syndrome (HHS) are common in people with COVID-19 infection, and are associated with significant insulin resistance, dehydration and acute kidney injury.
AD  - Department of Diabetes and Metabolism, St Bartholomew's and Royal London Hospitals.
Adult Critical Care Unit, Royal London Hospital, Barts Health NHS Trust.
Department of Psychology, Brunel University of London, London, UK.
AN  - 33025636
AU  - Huda, M. S. B.
AU  - Shaho, S.
AU  - Trivedi, B.
AU  - Fraterrigo, G.
AU  - Chandrarajan, L.
AU  - Zolfaghari, P.
AU  - Dovey, T. M.
AU  - Garrett, C. G.
AU  - Chowdhury, T. A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/dme.14416
DP  - NLM
ET  - 2020/10/08
J2  - Diabetic medicine : a journal of the British Diabetic Association
LA  - eng
N1  - 1464-5491
Huda, M S B
Orcid: 0000-0001-7303-199x
Shaho, S
Trivedi, B
Fraterrigo, G
Chandrarajan, L
Zolfaghari, P
Dovey, T M
Garrett, C G
Orcid: 0000-0003-4425-6609
Chowdhury, T A
Orcid: 0000-0001-8878-2331
Letter
England
Diabet Med. 2020 Oct 6:e14416. doi: 10.1111/dme.14416.
PY  - 2020
SN  - 0742-3071
SP  - e14416
ST  - Diabetic emergencies during the COVID-19 pandemic: a case-control study
T2  - Diabetic medicine : a journal of British Diabetic Association
TI  - Diabetic emergencies during the COVID-19 pandemic: a case-control study
ID  - 7790691
ER  - 

TY  - JOUR
AB  - The clinical spectrum of novel coronavirus infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia, with respiratory failure and even death Autoantibodies, especially antiphospholipid antibodies, can occur in severe infections Other autoantibodies are seldom reported Here, a 60-year-old female patient without dry-mouth symptoms detected positive for anti-60 kDa SSA/Ro antibodies on day 43 after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection To investigate this unique clinical case of SARS-CoV-2 infection, immunological characteristics of this case were detected by using flow cytometry and were compared to the other three groups of patients&amp;mdash;health subjects, 2019 novel coronavirus disease (COVID-19) recovery patients, and Sj&amp;ouml;gren&amp;rsquo;s syndrome (SS) patients Monitoring the autoantibody level and the development of subsequently related autoimmune diseases are warranted after SARS-CoV-2 infection
AU  - Huang, Po- I.
AU  - Lin, Ting-Chun
AU  - Liu, Feng-Cheng
AU  - Ho, Yi-Jung
AU  - Lu, Jeng-Wei
AU  - Lin, Te-Yu
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report
T2  - Medicina
TI  - Positive Anti-SSA/Ro Antibody in a Woman with SARS-CoV-2 Infection Using Immunophenotyping: A Case Report
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813216
ID  - 7793356
ER  - 

TY  - JOUR
AB  - The higher levels of cytokine storm may be associated with more severe COVID-19 disease development. In this study, we performed a systemic analysis to investigate whether the cytokines can help predict clinical severity in patients with COVID-19. This article is protected by copyright. All rights reserved.
AD  - Department of Rheumatology and Immunology, Peking University People's Hospital, 11 Xizhimen South St., Beijing, 100044, China.
Department of Nephrology and Rheumatology, Affiliated Hospital of Zunyi Medical University, Zunyi, 563000, China.
AN  - 33022800
AU  - Huang, F.
AU  - Liu, X.
AU  - Sun, X.
AU  - Li, Z.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/jmv.26580
DP  - NLM
ET  - 2020/10/07
J2  - Journal of medical virology
KW  - T cells
coronavirus disease 2019
cytokines
immunity
lymphocyte subsets
LA  - eng
N1  - 1096-9071
Huang, Fei
Orcid: 0000-0001-6954-3036
Liu, Xu
Sun, Xiaolin
Li, Zhanguo
Letter
United States
J Med Virol. 2020 Oct 6. doi: 10.1002/jmv.26580.
PY  - 2020
SN  - 0146-6615
ST  - IL-10 served as an indicator in severe COVID-19 patients
T2  - Journal of medical virology
TI  - IL-10 served as an indicator in severe COVID-19 patients
ID  - 7790942
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named 'coronavirus disease 2019' (COVID-19), which threatens human health and public safety. In this Review, we describe the basic virology of SARS-CoV-2, including genomic characteristics and receptor use, highlighting its key difference from previously known coronaviruses. We summarize current knowledge of clinical, epidemiological and pathological features of COVID-19, as well as recent progress in animal models and antiviral treatment approaches for SARS-CoV-2 infection. We also discuss the potential wildlife hosts and zoonotic origin of this emerging virus in detail.
AD  - CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, People's Republic of China.
CAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China. zlshi@wh.iov.cn.
AN  - 33024307
AU  - Hu, B.
AU  - Guo, H.
AU  - Zhou, P.
AU  - Shi, Z. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41579-020-00459-7
DP  - NLM
ET  - 2020/10/08
J2  - Nature reviews. Microbiology
LA  - eng
N1  - 1740-1534
Hu, Ben
Orcid: 0000-0001-9194-3474
Guo, Hua
Orcid: 0000-0003-4388-6465
Zhou, Peng
Orcid: 0000-0001-9863-4201
Shi, Zheng-Li
Orcid: 0000-0001-8089-163x
Journal Article
Review
England
Nat Rev Microbiol. 2020 Oct 6. doi: 10.1038/s41579-020-00459-7.
PY  - 2020
SN  - 1740-1526
ST  - Characteristics of SARS-CoV-2 and COVID-19
T2  - Nature reviews Microbiology
TI  - Characteristics of SARS-CoV-2 and COVID-19
ID  - 7790826
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic is unlike anything we have experienced in over a century. In the USA, waves of COVID-19 have migrated from the Northeast to the Sun Belt to the Midwest over the past year. Compared with females, males are more susceptible to SARS-CoV-2 infection, have more severe COVID-19 disease, and have higher death rates. In many countries, men are consistently more likely to die by a factor of almost 2. This article describes some of the mechanisms by which COVID-19 may be associated with male infertility, as discussed by Dutta and Sengupta.
AD  - University of Missouri Health Care, Columbia, MO, USA. hsual@alum.mit.edu.
Department of Obstetrics, Gynecology and Women's Health, MU Institute for Women's Health Research, University of Missouri School of Medicine, 500 North Keene Street, Columbia, MO, 65201, USA. hsual@alum.mit.edu.
University of Missouri Health Care, Columbia, MO, USA.
Department of Obstetrics, Gynecology and Women's Health, MU Institute for Women's Health Research, University of Missouri School of Medicine, 500 North Keene Street, Columbia, MO, 65201, USA.
University of Missouri School of Medicine, Columbia, MO, USA.
AN  - 33025529
AU  - Hsu, A. L.
AU  - Finlinson, A.
AU  - Warncke, K.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s43032-020-00304-5
DP  - NLM
ET  - 2020/10/08
J2  - Reproductive sciences (Thousand Oaks, Calif.)
KW  - Covid-19
Male fertility
SARS-CoV-2
LA  - eng
N1  - 1933-7205
Hsu, Albert L
Orcid: 0000-0001-8360-9556
Finlinson, Alex
Warncke, Kristen
Journal Article
United States
Reprod Sci. 2020 Oct 6. doi: 10.1007/s43032-020-00304-5.
PY  - 2020
SN  - 1933-7191
ST  - Mechanisms by Which SARS-CoV-2 May Impact Male Fertility
T2  - Reproductive sciences (Thousand Oaks, Calif)
TI  - Mechanisms by Which SARS-CoV-2 May Impact Male Fertility
ID  - 7790697
ER  - 

TY  - JOUR
AB  - The novel coronavirus disease (COVID-19) pandemic is a global threat presenting health, economic and social challenges that continue to escalate. Meta-population epidemic modeling studies in the susceptible-exposed-infectious-removed (SEIR) style have played important roles in informing public health and shaping policy making to mitigate the spread of COVID-19. These models typically rely on a key assumption on the homogeneity of the population. This assumption certainly cannot be expected to hold true in real situations; various geographic, socioeconomic and cultural environments affect the behaviors that drive the spread of COVID-19 in different communities. What&#039;s more, variation of intra-county environments creates spatial heterogeneity of transmission in different sub-regions. To address this issue, we develop a new human mobility flow-augmented stochastic SEIR-style epidemic modeling framework with the ability to distinguish different regions and their corresponding behavior. This new modeling framework is then combined with data assimilation and machine learning techniques to reconstruct the historical growth trajectories of COVID-19 confirmed cases in two counties in Wisconsin. The associations between the spread of COVID-19 and human mobility, business foot-traffic, race &amp;amp; ethnicity, and age-group are then investigated. The results reveal that in a college town (Dane County) the most important heterogeneity is spatial, while in a large city area (Milwaukee County) racial-ethnic heterogeneity becomes more apparent. Scenario studies further indicate a strong response of the spread rate on various reopening policies, which suggests that policymakers may need to take these heterogeneities into account very carefully when designing policies for mitigating the spread of COVID-19 and reopening.Competing Interest StatementThe authors have declared no competing interest.Funding StatementWe would like to thank the SafeGraph Inc. for providing the anonymous and aggregated place visits and human mobility flow data. S.G., Q.L., K.C, and J.P. acknowledge the funding support provided by the National Science Foundation (Award No. BCS-2027375). J.E. acknowledge the funding support provided by the National Science Foundation (Award No. DMS-1700884). Q.L., N.C. and X.H. are also supported by Data Science Initiative, provided by the University of Wisconsin �?Madison Office of the Chancellor and the Vice Chancellor for Research and Graduate Education with funding from the Wisconsin Alumni Research Foundation. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Only aggregated data are used in this study and IRB exempted for this research.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe official testing results of COVID-19 confirmed cases between March 11, 2020 and August 12, 2020 were obtained from the local COVID-19 Dashboards, created by the Public Health Offices of City of M dison &amp;amp; Dane County (https://publichealthmdc.com/coronavirus) and Milwaukee County (https://county.milwaukee.gov/EN/COVID-19). The census-tract level geographic boundaries with demographics and socioeconomic attributes were obtained from the U.S. Census Bureau. We collected points of interest (POIs) with aggregated foot-traffic information from SafeGraph. For each POI, the records of aggregated visitor patterns record the number of unique visitors and the number of total visits to each venue during a specified time window (i.e., hourly, weekly, and monthly); this allows us to estimate the foot-traffic of each venue and the origin-to-destination (O-D) spatial interaction flow patterns during the the study period (https://github.com/GeoDS/COVID19USFlows). We further aggregate the O-D flow matrices to the census-tract level to match the COVID-19 testing data. https://github.com/GeoDS/COVID19USFlowshttps://county.milwaukee.gov/EN/COVID-19
AU  - Hou, Xiao
AU  - Gao, Song
AU  - Li, Qin
AU  - Kang, Yuhao
AU  - Chen, Nan
AU  - Chen, Kaiping
AU  - Rao, Jinmeng
AU  - Ellenberg, Jordan S.
AU  - Patz, Jonathan A.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206763
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206763
ST  - Intra-county modeling of COVID-19 infection with human mobility: assessing spatial heterogeneity with business traffic, age and race (preprint)
T2  - medRxiv
TI  - Intra-county modeling of COVID-19 infection with human mobility: assessing spatial heterogeneity with business traffic, age and race (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206763.abstract
ID  - 7794741
ER  - 

TY  - GEN
AN  - NCT04578197
AU  - Hospital, Karolinska University
AU  - Institutet, Karolinska
C1  - 10/7/2020
DA  - August 18
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19
N1  - No Results Available
The association between changes in blood biomarkers for inflammation and the presence of neuroradiologically verified brain injury and neurocognitive disorder|The association between changes in blood biomarkers for nerve cell damage and the presence of neuroradiologically verified brain injury and neurocognitive disorder|The association between changes in blood biomarkers for neurodegeneration and the presence of neuroradiologically verified brain injury and neurocognitive disorder|The association between changes in coagulation factors and the presence of neuroradiologically verified brain injury and / or neurocognitive disorder|The association between changes in coagulation ability (ROTEM analysis - rotational thromboelastometry) and the presence of neuroradiologically verified brain injury and / or neurocognitive disorder|The association between changes in inflammatory biomarkers and the presence of neuroradiologically verified brain injury and / or neurocognitive disorder|Blood biomarker changes of inflammation impact|Blood biomarker changes of neurological impact|Neuroradiological changes|Clinical course - Pulmonary gas exchange|Clinical course - Lung function recording|Patient characteristics
All
100
Other
Observational Model: Cohort|Time Perspective: Prospective
Dnr 2020-02760
November 2022
PB  - https://ClinicalTrials.gov/show/NCT04578197
PY  - 2020
ST  - NeuroCovid - a Study of Intensive Care-requiring Covid-19 Patients
T2  - ClinicalTrials
TI  - NeuroCovid - a Study of Intensive Care-requiring Covid-19 Patients
UR  - https://ClinicalTrials.gov/show/NCT04578197
ID  - 7794700
ER  - 

TY  - JOUR
AB  - Summary Background Lopinavir–ritonavir has been proposed as a treatment for COVID-19 on the basis of in vitro activity, preclinical studies, and observational studies Here, we report the results of a randomised trial to assess whether lopinavir–ritonavir improves outcomes in patients admitted to hospital with COVID-19 Methods In this randomised, controlled, open-label, platform trial, a range of possible treatments was compared with usual care in patients admitted to hospital with COVID-19 The trial is underway at 176 hospitals in the UK Eligible and consenting patients were randomly allocated to either usual standard of care alone or usual standard of care plus lopinavir–ritonavir (400 mg and 100 mg, respectively) by mouth for 10 days or until discharge (or one of the other RECOVERY treatment groups: hydroxychloroquine, dexamethasone, or azithromycin) using web-based simple (unstratified) randomisation with allocation concealment Randomisation to usual care was twice that of any of the active treatment groups (eg, 2:1 in favour of usual care if the patient was eligible for only one active group, 2:1:1 if the patient was eligible for two active groups) The primary outcome was 28-day all-cause mortality Analyses were done on an intention-to-treat basis in all randomly assigned participants The trial is registered with ISRCTN, 50189673, and ClinicalTrials gov, NCT04381936 Findings Between March 19, 2020, and June 29, 2020, 1616 patients were randomly allocated to receive lopinavir–ritonavir and 3424 patients to receive usual care Overall, 374 (23%) patients allocated to lopinavir–ritonavir and 767 (22%) patients allocated to usual care died within 28 days (rate ratio 1·03, 95% CI 0·91�?·17;p=0·60) Results were consistent across all prespecified subgroups of patients We observed no significant difference in time until discharge alive from hospital (median 11 days [IQR 5 to &amp;gt;28] in both groups) or the proportion of patients discharged from hospital alive within 28 days (rate ratio 0·98, 95% CI 0·91�?·05;p=0·53) Among patients not on invasive mechanical ventilation at baseline, there was no significant difference in the proportion who met the composite endpoint of invasive mechanical ventilation or death (risk ratio 1·09, 95% CI 0·99�?·20;p=0·092) Interpretation In patients admitted to hospital with COVID-19, lopinavir–ritonavir was not associated with reductions in 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death These findings do not support the use of lopinavir–ritonavir for treatment of patients admitted to hospital with COVID-19 Funding Medical Research Council and National Institute for Health Research
AU  - Horby, Peter W.
AU  - Mafham, Marion
AU  - Bell, Jennifer L.
AU  - Linsell, Louise
AU  - Staplin, Natalie
AU  - Emberson, Jonathan
AU  - Palfreeman, Adrian
AU  - Raw, Jason
AU  - Elmahi, Einas
AU  - Prudon, Benjamin
AU  - Green, Christopher
AU  - Carley, Simon
AU  - Chadwick, David
AU  - Davies, Matthew
AU  - Wise, Matthew P.
AU  - Baillie, J. Kenneth
AU  - Chappell, Lucy C.
AU  - Faust, Saul N.
AU  - Jaki, Thomas
AU  - Jefferey, Katie
AU  - Lim, Wei Shen
AU  - Montgomery, Alan
AU  - Rowan, Kathryn
AU  - Juszczak, Edmund
AU  - Haynes, Richard
AU  - Landray, Martin J.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
T2  - Lancet
TI  - Lopinavir–ritonavir in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
UR  - https://doi.org/10.1016/S0140-6736(20)32013-4
ID  - 7793030
ER  - 

TY  - JOUR
AB  - Mass gatherings are routinely viewed as posing risks to physical health However, social psychological research shows mass gathering participation can also bring benefits to psychological well-being We describe how both sets of outcomes can be understood as arising from the distinctive forms of behavior that may be found when people?even strangers?come to define themselves and each other in terms of a shared social identity We show that many of the risks and benefits of participation are products of group processes;that these different outcomes can have their roots in the same core processes;and that knowledge of these process provides a basis for health promotion interventions to mitigate the risks and maximize the benefits of participation Throughout, we offer practical guidance as to how policy makers and practitioners should tailor such interventions
AU  - Hopkins, Nick
AU  - Reicher, Stephen
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Mass Gatherings, Health, and Well-Being: From Risk Mitigation to Health Promotion
T2  - Social Issues and Policy Review
TI  - Mass Gatherings, Health, and Well-Being: From Risk Mitigation to Health Promotion
UR  - https://doi.org/10.1111/sipr.12071
ID  - 7792681
ER  - 

TY  - JOUR
AB  - By the time athletics facilities and activities reopen on your campus, your institution has no doubt taken steps to reduce the risk of COVID-19 transmission But now is also the time to work with facilities staff and disability services providers to ensure mitigation efforts don&#039;t restrict access for individuals with disabilities, according to J Garofalo, Associate at KMA Architecture + Accessibility
AU  - Hope, Joan
AU  - McCarthy, Claudine
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Keep accessibility central in COVID-19 mitigation plans
T2  - College Athletics and Law
TI  - Keep accessibility central in COVID-19 mitigation plans
UR  - https://doi.org/10.1002/catl.30785
ID  - 7793317
ER  - 

TY  - JOUR
AU  - Hönzke, Katja
AU  - Obermayer, Benedikt
AU  - Mache, Christin
AU  - Fatykhova, Diana
AU  - Kessler, Mirjana
AU  - Dökel, Simon
AU  - Wyler, Emanuel
AU  - Hoffmann, Karen
AU  - Schulze, Jessica
AU  - Mieth, Maren
AU  - Hellwig, Katharina
AU  - Biere, Barbara
AU  - Brunotte, Linda
AU  - Mecate-Zambrano, Angeles
AU  - Hoppe, Judith
AU  - Dohmen, Melanie
AU  - Hinze, Christian
AU  - Elezkurtaj, Sefer
AU  - Tönnies, Mario
AU  - Bauer, Torsten
AU  - Eggeling, Stephan
AU  - Tran, Hong-Linh
AU  - Schneider, Paul
AU  - Neudecker, Jens
AU  - Rückert, Jens-Carsten
AU  - Schmidt-Ott, Kai
AU  - Busch, Jonas
AU  - Klauschen, Frederick
AU  - Horst, David
AU  - Radbruch, Helena
AU  - Heppner, Frank
AU  - Corman, Victor M.
AU  - Niemeyer, Daniela
AU  - Müller, Marcel Alexander
AU  - Goffinet, Christine
AU  - Beule, Dieter
AU  - Landthaler, Markus
AU  - Ludwig, Stephan
AU  - Niedobitek, Gerald
AU  - Suttorp, Norbert
AU  - Witzenrath, Martin
AU  - Gruber, Achim
AU  - Drosten, Christian
AU  - Sander, Leif E.
AU  - Wolff, Thorsten
AU  - Hippenstiel, Stefan
AU  - Hocke, Andreas C.
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - SARS-CoV-2, Covid-19, human lung, pneumonia, ARDS, alveolar macrophages, monocytes, immune activation, influenza, MERS-CoV, SARS-CoV, alveolar type II cells, autopsy, ACE2, TMPRSS2, permissiveness, lung damage, lung injury, alveolar damage, immunopathog
PY  - 2020
ST  - Human Lungs Show Limited Permissiveness for SARS-CoV-2 Due to Scarce ACE2 Levels But Strong Virus-Induced Immune Activation in Alveolar Macrophages (preprint)
T2  - SSRN
TI  - Human Lungs Show Limited Permissiveness for SARS-CoV-2 Due to Scarce ACE2 Levels But Strong Virus-Induced Immune Activation in Alveolar Macrophages (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3687020
ID  - 7794790
ER  - 

TY  - JOUR
AD  - James G. Hodge, Jr., J.D., LL.M., is the Peter Kiewit Foundation Professor of Law and Director, Center for Public Health Law and Policy, Sandra Day O'Connor College of Law, Arizona State University (ASU). Sarah Wetter, J.D., M.P.H., is a Law Fellow, O'Neill Institute for National and Global Health Law, Georgetown University Law Center. Emily Carey, Elyse Pendergrass, Claudia M. Reeves, and Hanna Reinke are Legal Researchers, Center for Public Health Law and Policy, and J.D. Candidates, Sandra Day O'Connor College of Law, ASU.
AN  - 33021176
AU  - Hodge, J. G., Jr.
AU  - Wetter, S.
AU  - Carey, E.
AU  - Pendergrass, E.
AU  - Reeves, C. M.
AU  - Reinke, H.
C1  - 10/7/2020
DA  - Sep
DB  - PubMed
DO  - 10.1177/1073110520958888
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
LA  - eng
N1  - 1748-720x
Hodge, James G Jr
Wetter, Sarah
Carey, Emily
Pendergrass, Elyse
Reeves, Claudia M
Reinke, Hanna
Journal Article
United States
J Law Med Ethics. 2020 Sep;48(3):603-607. doi: 10.1177/1073110520958888.
PY  - 2020
SN  - 1073-1105
SP  - 603-607
ST  - Legal "Tug-of-Wars" During the COVID-19 Pandemic: Public Health v. Economic Prosperity
T2  - Journal of law, medicine & ethics : a journal of American Society of Law, Medicine & Ethics
TI  - Legal "Tug-of-Wars" During the COVID-19 Pandemic: Public Health v. Economic Prosperity
VL  - 48
ID  - 7791045
ER  - 

TY  - JOUR
AB  - Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable and economical preventive and therapeutic options for COVID-19 treatment Zinc is a vital microelement that actively supports respiratory epithelium barrier integrity, innate and adaptive immune functions, and inflammatory regulations Moreover, zinc may also prevent viral entry, suppress viral replication, and mitigate the damages due to oxidative stress and hyperinflammatory reaction in patients with respiratory infections Hinokitiol (β-thujaplicin) is a natural monoterpenoid and is considered as a safe zinc ionophore to help zinc transport into cells It has been widely used in skin and oral care, and therapeutic products for its potent antiviral, antimicrobial, antifungal, anti-inflammatory, and anticancer applications The ongoing COVID-19 pandemic and the significant morbidity and mortality exist in the high-risk group of patients associated with other respiratory infections such as influenza, respiratory syncytial virus, and dengue fever There is an urgent need for the development of inexpensive, safe, and effective therapeutics to prevent and treat these viral infections Considering that hydroxychloroquine (HCQ), the most studied zinc ionophore drug for COVID-19, is linked to potentially serious side effects, we propose the implementation of hinokitiol as a zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and other viral infections
AU  - Hoang, Ba X.
AU  - Han, Bo
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections
T2  - Medical Hypotheses
TI  - A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections
UR  - https://doi.org/10.1016/j.mehy.2020.110333
ID  - 7793093
ER  - 

TY  - JOUR
AB  - COVID-19 patients are prone to pulmonary artery hypertension (PAH) and right ventricular pressure overload due to severe bilateral infiltrates, high ventilation pressures, persistent hypoxemia, pulmonary fibrosis and/or pulmonary embolism In patients on extra-corporeal membrane oxygenation (ECMO), this potentially leads to increased recirculation In the current report, we present a case in which continuous inhaled nitric oxide (iNO)-enriched ventilation was effective in terms of PAH and recirculation reduction in a COVID-19 patient on veno-venous ECMO
AU  - Heuts, Samuel
AU  - Ubben, Johannes F.
AU  - Banks-Gonzales, Vanessa
AU  - Sels, Jan-Willem
AU  - Lorusso, Roberto
AU  - van Mook, Walther N. K. A.
AU  - Delnoij, Thijs S. R.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Nitric oxide ventilation improves recirculation and right ventricular function during veno-venous extracorporeal membrane oxygenation in a COVID-19 patient
T2  - Journal of Cardiothoracic and Vascular Anesthesia
TI  - Nitric oxide ventilation improves recirculation and right ventricular function during veno-venous extracorporeal membrane oxygenation in a COVID-19 patient
UR  - https://doi.org/10.1053/j.jvca.2020.09.137
ID  - 7792993
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 is responsible for the coronavirus disease 2019 (COVID-19) and the current health crisis. Despite intensive research efforts, the genes and pathways that contribute to COVID-19 remain poorly understood. We therefore used an integrative genomics (IG) approach to identify candidate genes responsible for COVID-19 and its severity. We used Bayesian colocalization (COLOC) and summary-based Mendelian randomization to combine gene expression quantitative trait loci (eQTLs) from the Lung eQTL (n=1,038) and eQTLGen (n=31,784) studies with published COVID-19 genome-wide association study (GWAS) data from the COVID-19 Host Genetics Initiative. Additionally, we used COLOC to integrate plasma protein quantitative trait loci (pQTL) from the INTERVAL study (n=3,301) with COVID-19-associated loci. Finally, we determined any causal associations between plasma proteins and COVID-19 using multi-variable two-sample Mendelian randomization (MR). We found that the expression of 20 genes in lung and 31 genes in blood was associated with COVID-19. Of these genes, only three (LZTFL1, SLC6A20 and ABO) had been previously linked with COVID-19 in GWAS. The novel loci included genes involved in interferon pathways (IL10RB, IFNAR2 and OAS1). Plasma ABO protein, which is associated with blood type in humans, demonstrated a significant causal relationship with COVID-19 in MR analysis; increased plasma levels were associated with an increased risk of having COVID-19 and risk of severe COVID-19. In summary, our study identified genes associated with COVID-19 that may be prioritized for future investigation. Importantly, this is the first study to demonstrate a causal association between plasma ABO protein and COVID-19.Competing Interest StatementS.M. reports personal fees from Novartis and Boehringer-Ingelheim, outside the submitted work. W.T. reports fees to Institution from Roche-Ventana, AbbVie, Merck-Sharp-Dohme and Bristol-Myers-Squibb, outside the submitted work. M.v.d.B. reports research grants paid to Institution from Astra Zeneca, Novartis, outside the submitted work. D.D.S. reports research funding from AstraZeneca and received honoraria for speaking engagements from Boehringer Ingelheim and AstraZeneca over the past 36 months, outside of the submitted work.Funding StatementA.I.H.C. and S.M. are funded by MITACS Accelerate grant. D.D.S. holds the De Lazzari Family Chair at HLI and a Tier 1 Canada Research Chair in COPD. Y.B. holds a Canada Research Chair in Genomics of Heart and Lung Diseases.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Not applicable. Publicly available third-party data sets were used for this.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe results associated to this manuscript are available on the additional file. Specific datasets used to conduct this research are available as follow: The COVID-19 summary statistic can be accessed through the COVID-19 HG website (https://www.covid19hg.org/). Lung eQTL study expression and genotype data can be obtained through GEO platform accession number GSE23546 and the dbGaP Study Accession phs001745.v1.p1, respect vely. Blood cis-eQTLs summary statistics can be accessed through the eQTLGen website (https://www.eqtlgen.org/cis-eqtls.html). The INTERVAL study pQTLs summary statistic are available through the European Genotype Archive (accession number EGAS00001002555).
AU  - Hernandez Cordero, Ana I.
AU  - Li, Xuan
AU  - Milne, Stephen
AU  - Yang, Chen Xi
AU  - Bosse, Yohan
AU  - Joubert, Philippe
AU  - Timens, Wim
AU  - Berge, Maarten van den
AU  - Nickle, David
AU  - Hao, Ke
AU  - Sin, Don D.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20207118
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20207118
ST  - Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 (preprint)
T2  - medRxiv
TI  - Multi-omics highlights ABO plasma protein as a causal risk factor for COVID-19 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20207118.abstract
ID  - 7794763
ER  - 

TY  - JOUR
AU  - Herbreteau, Denis
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID 19 �?Journal de Bord - 6/6/2020: Non, cette fois-ci, ce ne fut pas ma guerre!
T2  - La Presse Médicale Formation
TI  - COVID 19 �?Journal de Bord - 6/6/2020: Non, cette fois-ci, ce ne fut pas ma guerre!
UR  - https://doi.org/10.1016/j.lpmfor.2020.09.019
ID  - 7793108
ER  - 

TY  - JOUR
AB  - Due to the ongoing COVID-19 pandemic, an unprecedented number of people worldwide is currently affected by quarantine or isolation. These measures have been suggested to negatively impact on mental health. We conducted the first systematic literature review and meta-analysis assessing the psychological effects in both quarantined and isolated persons compared to non-quarantined and non-isolated persons. PubMed, PsycINFO, and Embase databases were searched for studies until April 22, 2020 (Prospero Registration-No.: CRD42020180043). We followed PRISMA and MOOSE guidelines for data extraction and synthesis and the Newcastle-Ottawa Scale for assessing risk of bias of included studies. A random-effects model was implemented to pool effect sizes of included studies. The primary outcomes were depression, anxiety, and stress-related disorders. All other psychological parameters, such as anger, were reported as secondary outcomes. Out of 6807 screened articles, 25 studies were included in our analyses. Compared to controls, individuals experiencing isolation or quarantine were at increased risk for adverse mental health outcomes, particularly after containment duration of 1 week or longer. Effect sizes were summarized for depressive disorders (odds ratio 2.795; 95% CI 1.467-5.324), anxiety disorders (odds ratio 2.0; 95% CI 0.883-4.527), and stress-related disorders (odds ratio 2.742; 95% CI 1.496-5.027). Among secondary outcomes, elevated levels of anger were reported most consistently. There is compelling evidence for adverse mental health effects of isolation and quarantine, in particular depression, anxiety, stress-related disorders, and anger. Reported determinants can help identify populations at risk and our findings may serve as an evidence-base for prevention and management strategies.
AD  - Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.
Department of Psychiatry and Psychotherapy, University of Cologne Medical School, Cologne, Germany.
Berlin School of Mind and Brain, Berlin, Germany.
Bernstein Center of Computational Neuroscience Berlin, Berlin, Germany.
Department of Psychiatry and Psychotherapy, Charité Campus Mitte, Charité Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany. andreas.heinz@charite.de.
Berlin School of Mind and Brain, Berlin, Germany. andreas.heinz@charite.de.
Bernstein Center of Computational Neuroscience Berlin, Berlin, Germany. andreas.heinz@charite.de.
AN  - 33025099
AU  - Henssler, J.
AU  - Stock, F.
AU  - van Bohemen, J.
AU  - Walter, H.
AU  - Heinz, A.
AU  - Brandt, L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00406-020-01196-x
DP  - NLM
ET  - 2020/10/08
J2  - European archives of psychiatry and clinical neuroscience
KW  - Containment strategies
Isolation
Mental disorder
Mental health
Meta-analysis
Psychological effects
Quarantine
Systematic review
LA  - eng
N1  - 1433-8491
Henssler, Jonathan
Stock, Friederike
van Bohemen, Joris
Walter, Henrik
Heinz, Andreas
Brandt, Lasse
Journal Article
Germany
Eur Arch Psychiatry Clin Neurosci. 2020 Oct 6. doi: 10.1007/s00406-020-01196-x.
PY  - 2020
SN  - 0940-1334
ST  - Mental health effects of infection containment strategies: quarantine and isolation-a systematic review and meta-analysis
T2  - European archives of psychiatry and clinical neuroscience
TI  - Mental health effects of infection containment strategies: quarantine and isolation-a systematic review and meta-analysis
ID  - 7790723
ER  - 

TY  - JOUR
AB  - Oncologic patients are regarded as the population most at risk of developing a severe course of COVID-19 due to the fact that malignant diseases and chemotherapy often weaken the immune system. In the face of the ongoing SARS-CoV-2 pandemic, how particular patients deal with this infection remains an important question. In the period between the 15 and 26 April 2020, a total of 1227 patients were tested in one of seven oncologic outpatient clinics for SARS-CoV-2, regardless of symptoms, employing RT-qPCR. Of 1227 patients, 78 (6.4%) were tested positive of SARS-CoV-2. Only one of the patients who tested positive developed a severe form of COVID-19 with pneumonia (CURB-65 score of 2), and two patients showed mild symptoms. Fourteen of 75 asymptomatic but positively tested patients received chemotherapy or chemo-immunotherapy according to their regular therapy algorithm (�u4 weeks of SARS-CoV-2 test), and 48 of 78 (61.5%) positive-tested patients received glucocorticoids as co-medication. None of the asymptomatic infected patients showed unexpected complications due to the SARS-CoV-2 infection during the cancer treatment. These data clearly contrast the view that patients with an oncologic disease are particularly vulnerable to SARS-CoV-2 and suggest that compromising therapies could be continued or started despite the ongoing pandemic. Moreover the relatively low appearance of symptoms due to COVID-19 among patients on chemotherapy and other immunosuppressive co-medication like glucocorticoids indicate that suppressing the response capacity of the immune system reduces disease severity.
AD  - Sigmund Freud University Vienna, Vienna, Austria.
MVZ Freising Laboratory, Freising, Germany.
Division of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
Cancer Center Dachau, Dachau, Germany.
Fraunhofer Institute of Optronics, System Technologies, and Image Exploitation IOSB, Karlsruhe, Germany.
Department of Obstetrics, Helios Clinic Pasing, München, Germany.
Oncological Center Fürstenfeldbruck, Dachau, Germany.
Oncological Center Donauwoerth, Donauwoerth, Germany.
BioVariance GmbH, Waldsassen, Germany.
Steinbeishochschule Berlin, Berlin, Germany.
AN  - 33022856
AU  - Hempel, L.
AU  - Piehler, A.
AU  - Pfaffl, M. W.
AU  - Molnar, J.
AU  - Kirchner, B.
AU  - Robert, S.
AU  - Veloso, J.
AU  - Gandorfer, B.
AU  - Trepotec, Z.
AU  - Mederle, S.
AU  - Keim, S.
AU  - Milani, V.
AU  - Ebner, F.
AU  - Schweneker, K.
AU  - Fleischmann, B.
AU  - Kleespies, A.
AU  - Scheiber, J.
AU  - Hempel, D.
AU  - Zehn, D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/cam4.3435
DP  - NLM
ET  - 2020/10/07
J2  - Cancer medicine
LA  - eng
N1  - 2045-7634
Hempel, Louisa
Piehler, Armin
Pfaffl, Michael W
Molnar, Jakob
Kirchner, Benedikt
Robert, Sebastian
Veloso, Julia
Gandorfer, Beate
Trepotec, Zeljka
Mederle, Stefanie
Keim, Sabine
Milani, Valeria
Ebner, Florian
Schweneker, Katrin
Fleischmann, Bastian
Kleespies, Axel
Scheiber, Josef
Hempel, Dirk
Orcid: 0000-0001-7449-3053
Zehn, Dietmar
Journal Article
United States
Cancer Med. 2020 Oct 6. doi: 10.1002/cam4.3435.
PY  - 2020
SN  - 2045-7634
ST  - SARS-CoV-2 infections in cancer outpatients-Most infected patients are asymptomatic carriers without impact on chemotherapy
T2  - Cancer medicine
TI  - SARS-CoV-2 infections in cancer outpatients-Most infected patients are asymptomatic carriers without impact on chemotherapy
ID  - 7790936
ER  - 

TY  - JOUR
AB  - The cancer population seems to be more susceptible to COVID-19 infection and have worse outcomes. We had to adapt our medical practice to protect our patients without compromising their cancer prognosis. The national PRATICOVID study aims to describe the adaptation of cancer patient care for this population. We analyzed data from nine different institutions. The primary endpoint was to assess the prevalence of adapted patient care during the pandemic. The secondary endpoints were to describe the point of view of clinicians and patients during and after the pandemic. We analyzed 435 medical procedures between 9(th) of March and 30(th) of April. Because of the COVID-19 pandemic, 47.6% of the outpatients received modified patient care. Twenty-four percent of scheduled surgeries were postponed, or were performed without perioperative chemotherapy, 18.4% followed a hypofractioned schedule, and 57% had an adaptive systemic protocol (stopped, oral protocol, and spacing between treatments). Seventy percent of physicians used telemedicine. During this period, 67% of the physicians did not feel distressed taking care of their patients. However, 70% of physicians are worried about the aftermath of the lockdown, as regards future patient care. The PRATICOVID study is the first to assess modification of patient care in cancer outpatients during an epidemic. With this unprecedented crisis, physicians were able to adapt their practice in order to protect their patients against the virus while ensuring continuity of patient care. But physicians are worried about the aftereffects of the lockdown specifically in regard to care pathway issues.
AD  - Clinical Research unit, Military Hospital Begin, Saint-Mandé, France.
Department of Medical oncology, Clinique HARTMANN, Neuilly-sur-Seine, France.
Department of Medical oncology, Military Hospital Sainte-Anne, Toulon, France.
Department of Gastroenterology, Military Hospital Percy, Clamart, France.
Department of Oncology, Tenon University Hospital, Institut Universitaire de Cancérologie AP-HP. Sorbonne Université, Paris, France.
Department of Radiation Oncology, Hôpital Tenon, Paris, France.
Department of Radiation oncology, Hôpital Henri Mondor, Créteil, France.
Department of Medical Oncology, Hôpital Henri Mondor, Créteil, France.
Department of Radiation Oncology, Clinique HARTMANN, Neuilly-sur-Seine, France.
Department of medical oncology, HEGP, APHP.Centre, Paris, France.
Department of Urology, Clinque Métivet, Saint-Maur-des Fossés, France.
Department of Pulmonology, Military Hospital Percy, Clamart, France.
Department of Neurology, Military Hospital Percy, Clamart, France.
CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail) - UMR-S 1085, Pointe-à-Pitre, France.
AN  - 33022134
AU  - Helissey, C.
AU  - Cessot, A.
AU  - Boudin, L.
AU  - Romeo, E.
AU  - Prieux, C.
AU  - Ghebriou, D.
AU  - Schernberg, A.
AU  - Grellier, N.
AU  - Joly, C.
AU  - Bauduceau, O.
AU  - Thibault, C.
AU  - Mamou, E.
AU  - Raynal, G.
AU  - Serey Eiffel, S.
AU  - Le Floch, H.
AU  - Ricard, D.
AU  - Brureau, L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/cam4.3503
DP  - NLM
ET  - 2020/10/07
J2  - Cancer medicine
KW  - Pandemic COVID-19
Physicians
cancer patient care
LA  - eng
N1  - 2045-7634
Helissey, Carole
Orcid: 0000-0002-7774-349x
Cessot, Anatole
Boudin, Laurys
Romeo, Emile
Prieux, Caroline
Ghebriou, Djamel
Schernberg, Antoine
Grellier, Noemie
Joly, Charlotte
Bauduceau, Olivier
Thibault, Constance
Mamou, Elodie
Raynal, Gauthier
Serey Eiffel, Sophie
Le Floch, Hervé
Ricard, Damien
Brureau, Laurent
Orcid: 0000-0001-9623-8221
Journal Article
United States
Cancer Med. 2020 Oct 6. doi: 10.1002/cam4.3503.
PY  - 2020
SN  - 2045-7634
ST  - Evaluation of medical practices in oncology in the context of the COVID-19 pandemic in France: Physicians' point of view: the PRATICOVID study
T2  - Cancer medicine
TI  - Evaluation of medical practices in oncology in the context of the COVID-19 pandemic in France: Physicians' point of view: the PRATICOVID study
ID  - 7790978
ER  - 

TY  - JOUR
AB  - At the end of 2019, a new coronavirus disease, COVID�?9, emerged and quickly spread around the world. Severe acute respiratory syndrome Coronavirus 2 (SARS‐CoV�?), the causative virus of this disease, belongs to the β‐coronavirus family, together with SARS and middle east respiratory syndrome, and has similar biological characteristics to these viruses. For obstetricians, the susceptibility and prognoses of pregnant women and the effects of the infection on the fetus have been the focus of attention; however, at present, the seriousness of the disease in pregnant women is not apparent, and COVID�?9 does not increase the rate of miscarriage, stillbirth, preterm labor or teratogenicity. Even so, carriers might transmit SARS‐CoV�? to pregnant women. Thus, we must keep in mind that all medical personnel must understand and maintain standard precautions in their clinical and laboratory practices.
AD  - Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan ; Department of Obstetrics and Gynecology, C.S. Mott Center for Human Growth and Development, Wayne State University, Detroit, Michigan, USA ; Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan
AN  - 2448516074
AU  - Hayakawa, Satoshi
AU  - Shihoko, Komine‐Aizawa
AU  - Mor, Gil G.
C1  - 10/7/2020
DA  - Oct 2020
2020-10-06
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/jog.14384
DP  - ProQuest Central
IS  - 10
KW  - Medical Sciences--Obstetrics And Gynecology
COVID�?9
pregnancy
SARS‐CoV�?
Coronaviruses
Severe acute respiratory syndrome coronavirus 2
Womens health
COVID-19
Medical personnel
Teratogenicity
Pandemics
Fetuses
Coronaviridae
LA  - English
N1  - Copyright - © 2020 Japan Society of Obstetrics and Gynecology
SubjectsTermNotLitGenreText - Coronaviridae
PY  - 2020
SN  - 1341-8076
SP  - 1958-1966
ST  - Covid�?9 pandemic and pregnancy
T2  - Journal of Obstetrics and Gynaecology Research
TI  - Covid�?9 pandemic and pregnancy
UR  - https://www.proquest.com/docview/2448516074?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Covid%E2%80%9019+pandemic+and+pregnancy&title=The+Journal+of+Obstetrics+and+Gynaecology+Research&issn=13418076&date=2020-10-01&volume=46&issue=10&spage=1958&au=Hayakawa%2C+Satoshi%3BShihoko+Komine%E2%80%90Aizawa%3BMor%2C+Gil+G&isbn=&jtitle=The+Journal+of+Obstetrics+and+Gynaecology+Research&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fjog.14384
VL  - 46
ID  - 7789889
ER  - 

TY  - JOUR
AB  - Recent reports have suggested an increased risk of pulmonary embolism (PE) related to COVID-19. The aim of this cohort study is to compare the incidence of PE during a 3-year period and to assess the characteristics of PE in COVID-19. We studied consecutive patients presenting with PE (January 2017-April 2020). Clinical presentation, computed tomography (CT) and biological markers were systematically assessed. We recorded the global number of hospitalizations during the COVID-19 pandemic and during the same period in 2018-2019. We included 347 patients: 326 without COVID-19 and 21 with COVID-19. Patients with COVID-19 experienced more likely dyspnea (p=0.04), had lower arterial oxygen saturation (p0.001), higher C-reactive protein and white blood cell (WBC) count (p0.0001 and p=0.001, respectively), and a significantly higher in-hospital mortality (14% versus 3.4%, p=0.04). Among COVID-19 patients, diagnosis of PE was performed at admission in 38% (n=8). COVID-19 patients with diagnosis of PE during hospitalization (n=13) had significantly more dyspnea (p=0.04), lower arterial oxygen saturation (p=0.01), less proximal PE (p=0.02), and higher heart rate (p=0.009), CT severity score (p=0.001), C-reactive protein (p=0.006) and WBC count (p=0.04). During the COVID-19 outbreak, a 97.4% increase of PE incidence was observed as compared to 2017-2019 and the proportion of hospitalizations related to PE was 3.7% versus 1.3% in 2018-2019 (p0.0001). In conclusion, the COVID-19 pandemic leads to a dramatic increased incidence of PE. Physicians should be aware that PE may be diagnosed at admission, but also after several days of hospitalization, with a different clinical, CT and biological features of thrombotic disease.
AD  - Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de référence des cardiomyopathies et des troubles du rythme cardiaque héréditaires ou rares, Université de Versailles-Saint Quentin (UVSQ), Boulogne-Billancourt, France. marie.hauguel@aphp.fr.
INSERM U-1018, CESP, Epidémiologie clinique, UVSQ, Université de Paris Saclay, Villejuif, France. marie.hauguel@aphp.fr.
AP-HP, Hôpital Universitaire Ambroise Paré, Service de Cardiologie et des Maladies Vasculaires, 9 avenue Charles de Gaulle, 92100, Boulogne, France. marie.hauguel@aphp.fr.
ACTION Study Group, Paris, France. marie.hauguel@aphp.fr.
Department of Radiology, Ambroise Paré Hospital, AP-HP, UVSQ, Boulogne-Billancourt, France.
INSERM U 1179, Handicap Neuromusculaire, UVSQ Paris-Saclay, Garches, France.
Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de référence des cardiomyopathies et des troubles du rythme cardiaque héréditaires ou rares, Université de Versailles-Saint Quentin (UVSQ), Boulogne-Billancourt, France.
INSERM U-1018, CESP, Epidémiologie clinique, UVSQ, Université de Paris Saclay, Villejuif, France.
Intensive Care Unit, Ambroise Paré Hospital, AP-HP, UVSQ, Boulogne-Billancourt, France.
Department of medical information, Ambroise Paré Hospital, APHP, Boulogne-Billancourt, France.
Department of Respiratory Diseases and Thoracic Oncology, Ambroise Paré Hospital, APHP, UVSQ, Boulogne-Billancourt, France.
EA 4340 BECCOH, UVSQ, Université Paris Saclay, 92100, Boulogne-Billancourt, France.
Department of Emergency Medicine, Ambroise Paré Hospital, AP-HP, UVSQ, Boulogne-Billancourt, France.
FHU SEPSIS IFrancenserm UMR 1144, Université́ Paris Centre, Paris, France.
AN  - 33025502
AU  - Hauguel-Moreau, M.
AU  - Hajjam, M. E.
AU  - De Baynast, Q.
AU  - Vieillard-Baron, A.
AU  - Lot, A. S.
AU  - Chinet, T.
AU  - Mustafic, H.
AU  - Bégué, C.
AU  - Carlier, R. Y.
AU  - Geri, G.
AU  - Dubourg, O.
AU  - Beaune, S.
AU  - Mansencal, N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11239-020-02292-4
DP  - NLM
ET  - 2020/10/08
J2  - Journal of thrombosis and thrombolysis
KW  - Covid-19
Pulmonary embolism
Thrombosis
LA  - eng
N1  - 1573-742x
Hauguel-Moreau, Marie
Orcid: 0000-0002-9804-1868
Hajjam, Mostafa El
De Baynast, Quentin
Vieillard-Baron, Antoine
Lot, Anne-Sophie
Chinet, Thierry
Mustafic, Hazrije
Bégué, Céline
Carlier, Robert Yves
Geri, Guillaume
Dubourg, Olivier
Beaune, Sébastien
Mansencal, Nicolas
Journal Article
Netherlands
J Thromb Thrombolysis. 2020 Oct 6. doi: 10.1007/s11239-020-02292-4.
PY  - 2020
SN  - 0929-5305
ST  - Occurrence of pulmonary embolism related to COVID-19
T2  - Journal of thrombosis and thrombolysis
TI  - Occurrence of pulmonary embolism related to COVID-19
ID  - 7790702
ER  - 

TY  - JOUR
AU  - Hassink, Wolter
AU  - Kalb, Guyonne R. J.
AU  - Meekes, Jordy
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - COVID-19, Coronavirus hotspots, Lockdown, Employment, Working hours, Wages
PY  - 2020
ST  - The Dutch Labour Market Early on in the COVID-19 Outbreak: Regional Coronavirus Hotspots and the National Lockdown (preprint)
T2  - SSRN
TI  - The Dutch Labour Market Early on in the COVID-19 Outbreak: Regional Coronavirus Hotspots and the National Lockdown (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3702133
ID  - 7794795
ER  - 

TY  - JOUR
AB  - Bats are known reservoirs of Nipah virus (NiV) and some filoviruses and also appear likely to harbor the evolutionary progenitors of severe acute respiratory syndrome coronavirus (SARS-CoV), severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), and Middle East respiratory syndrome coronavirus (MERS-CoV) While bats are considered a reservoir of deadly viruses, little is known about people&amp;rsquo;s knowledge, attitudes, and perceptions of bat conservation and ecology The current study aimed to assess community people&amp;rsquo;s knowledge, attitudes, and perceptions of bat ecology, myths, and the role of bats in transmitting NiV in Bangladesh Since 2001, NiV has been a continuous threat to public health with a mortality rate of approximately 70% in Bangladesh Over the years, many public health interventions have been implemented to raise awareness about bats and the spreading of NiV among the community peoples of Nipah outbreak areas (NOAs) and Nipah non-outbreak areas (NNOAs) We hypothesized that people from both areas might have similar knowledge of bat ecology and myths about bats but different knowledge regarding their role in the spreading of NiV Using a four-point Likert scale-based questionnaire, our analysis showed that most people lack adequate knowledge regarding the role of bats in maintaining the ecological balance and instead trust their beliefs in different myths about bats Factor score analysis showed that respondents&amp;rsquo;gender (p = 0 01), the outbreak status of the area (p = 0 03), and their occupation (p = 0 04) were significant factors influencing their knowledge of bat ecology and myths A regression analysis showed that farmers had 0 34 times the odds of having correct or positive knowledge of bat ecology and myths than businesspersons (odds ratio (OR) = 0 34, 95% confidence interval (95% CI) = 0 15&amp;ndash;0 78, p = 0 01) Regarding the spreading of NiV via bats, people had a lower level of knowledge In NOAs, age (p = 0 00), occupation (p = 0 00), and level of education (p = 0 00) were found to be factors contributing to the amount of knowledge regarding the transmission of NiV, whereas in NNOAs, the contributing factors were occupation (p = 0 00) and level of education (p = 0 01) Regression analysis revealed that respondents who were engaged in services (OR = 3 02, 95% CI = 1 07&amp;ndash;8 54, p = 0 04) and who had completed primary education (OR = 3 06, 95% CI = 1 02&amp;ndash;9 17, p &amp;lt;0 05) were likely to have correct knowledge regarding the spreading of NiV Based on the study results, we recommend educational interventions for targeted groups in the community, highlighting the ecosystem services and conservation of bats so as to improve people&amp;rsquo;s current knowledge and subsequent behavior regarding the role of bats in ecology and the spreading of NiV in Bangladesh
AU  - Hassan, Mohammad Mahmudul
AU  - Kalam, Md Abul
AU  - Alam, Mahabub
AU  - Shano, Shahanaj
AU  - Faruq, Abdullah Al
AU  - Hossain, Md Saddam
AU  - Islam, Md Nurul
AU  - Khan, Shahneaz Ali
AU  - Islam, Ariful
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Understanding the Community Perceptions and Knowledge of Bats and Transmission of Nipah Virus in Bangladesh
T2  - Animals
TI  - Understanding the Community Perceptions and Knowledge of Bats and Transmission of Nipah Virus in Bangladesh
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813215
ID  - 7793357
ER  - 

TY  - JOUR
AB  - In this review article, it is highlighted the implications of pleiotropic functions of interleukin-6 (IL-6) for one of the therapeutic options targeting for COVID-19. Moreover, it is discussed how real-world data and trials with IL-6 signaling blockade will be crucial in informing the development of new treatment for COVID-19 pneumonia. Given physiological roles of IL-6 in inflammatory conditions and the data from real world, IL-6 signal inhibitors, along with standard of care (SOC) treatment, might provide efficacy, offering the potential to treat COVID-19 in hospitalized populations more effectively than current SOC alone. Therefore, on-going and planned randomized placebo-controlled studies in combination with SOC and other therapeutics to assess safety and efficacy of IL-6 signal inhibitors in hospitalized patients with severe COVID-19 pneumonia will be warranted to address the high unmet need and burden of disease in this severely ill population.
AD  - Chugai Pharmaceutical Co., Ltd., 1-1 Nihonbashi-Muromachi 2-Chome, Chuo-ku, Tokyo, 103-8324 Japan. GRID: grid.418587.7
AN  - 33024459
AU  - Hashizume, M.
C1  - 10/7/2020
C2  - PMC7533147
DB  - PubMed
DO  - 10.1186/s41232-020-00134-7
DP  - NLM
ET  - 2020/10/08
J2  - Inflammation and regeneration
KW  - COVID-19 pneumonia
Cytokine release syndrome
Interleukin-6
Sarilumab
Siltuximab
Tocilizumab
LA  - eng
N1  - Hashizume, Misato
Journal Article
Review
England
Inflamm Regen. 2020 Oct 5;40:24. doi: 10.1186/s41232-020-00134-7. eCollection 2020.
PY  - 2020
SN  - 1880-9693 (Print)
1880-8190
SP  - 24
ST  - Outlook of IL-6 signaling blockade for COVID-19 pneumonia
T2  - Inflammation and regeneration
TI  - Outlook of IL-6 signaling blockade for COVID-19 pneumonia
VL  - 40
ID  - 7790792
ER  - 

TY  - JOUR
AB  - Background: Huntington's disease (HD) is a complex neurodegenerative disorder that causes impairment in cognitive, motor, and psychological function and requires subspecialty neurological and interdisciplinary care. Access to subspecialty care for HD is restricted by disability from the disease, lack of trained providers, and barriers to care for disadvantaged and rural populations. Program Description: Since 1999, the University of Virginia HD clinic has used telemedicine to provide clinical services, consultation, and staff training. Initially, encounters were scheduled with the neurologist on a case-by-case basis at outlying rural clinics and community hospitals. Since 2015, telemedicine visits have been conducted by the entire interdisciplinary HD team and access has been extended to homes and long-term care facilities. This infrastructure was used to conduct a virtual clinic 2 days after initiation of coronavirus disease (COVID) mitigation. The clinic has continued to provide subspecialty and interdisciplinary care through telemedicine while clinic access has been restricted. A total of 69 individuals have been seen in 127 telemedicine visits, 56 of which were conducted by the interdisciplinary team. Conclusions: Telemedicine can provide high-quality subspecialty neurological and interdisciplinary care for HD that offers continuity across a wide range of care settings, and can overcome both anticipated and unanticipated barriers to access.
AD  - Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
AN  - 33021901
AU  - Harrison, M. B.
AU  - Morrissey, D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1089/tmj.2020.0316
DP  - NLM
ET  - 2020/10/07
J2  - Telemedicine journal and e-health : the official journal of the American Telemedicine Association
KW  - Huntington's disease
interdisciplinary care
telemedicine
LA  - eng
N1  - 1556-3669
Harrison, Madaline B
Morrissey, Dana
Journal Article
United States
Telemed J E Health. 2020 Oct 6. doi: 10.1089/tmj.2020.0316.
PY  - 2020
SN  - 1530-5627
ST  - Interdisciplinary Telemedicine Services for Huntington's Disease: A 20-Year Experience
T2  - Telemedicine journal and e-health : official journal of American Telemedicine Association
TI  - Interdisciplinary Telemedicine Services for Huntington's Disease: A 20-Year Experience
ID  - 7790996
ER  - 

TY  - JOUR
AB  - Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) constitute a worldwide public health crisis. In light of the AD/ADRD epidemic now existing within the global COVID-19 pandemic, the need for global action to improve dementia care is greater than ever. The article collection "Dementia- an Interdisciplinary Approach," in the Israeli Journal of Health Policy and Research (IJHPR) highlights the need for interprofessional approaches to improving outcomes for people living with dementia and their care partners, as well as the complexities of conducting dementia care research.
AD  - Department of Health Services, Policy, and Practice, School of Public Health, Brown University, Box G-S121 (6), Providence, RI, 02912, USA. jill_s_harrison@brown.edu.
Department of Health Services, Policy, and Practice, School of Public Health, Brown University, Box G-S121 (6), Providence, RI, 02912, USA.
Providence Veterans Administration Medical Center, Center of Innovation in Health Services Research and Development Service, Providence, RI, USA.
Hebrew SeniorLife Hinda and Arthur Marcus Institute for Aging Research, Boston, MA, USA.
Beth Israel Deaconess Medical Center, Department of Medicine, Boston, MA, USA.
AN  - 33023673
AU  - Harrison, J.
AU  - Mor, V.
AU  - Mitchell, S.
AU  - McCarthy, E. P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13584-020-00411-3
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Israel journal of health policy research
KW  - Alzheimer’s disease
Dementia care
Non-pharmacological interventions
Pragmatic clinical trials
LA  - eng
N1  - 2045-4015
Harrison, Jill
Orcid: 0000-0001-6194-5452
Mor, Vincent
Mitchell, Susan
McCarthy, Ellen P
U54AG063546/AG/NIA NIH HHS/United States
Journal Article
England
Isr J Health Policy Res. 2020 Oct 6;9(1):50. doi: 10.1186/s13584-020-00411-3.
PY  - 2020
SN  - 2045-4015
SP  - 50
ST  - Reflections on the IJHPR's article collection on dementia
T2  - Israel journal of health policy research
TI  - Reflections on the IJHPR's article collection on dementia
VL  - 9
ID  - 7790889
ER  - 

TY  - JOUR
AB  - Today’s female physicians face a “triple whammy�?of structural discrimination, rigid work expectations, and increasing educational debt Coronavirus disease 2019 is disproportionately amplifying these forces on women The burden of these forces on women, the likely long-term consequences, and some preliminary solutions are discussed
AU  - Hardy, Seth M.
AU  - McGillen, Kathryn
AU  - Hausman, Bernice L.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Dr Mom’s Added Burden
T2  - Journal of American College of Radiology
TI  - Dr Mom’s Added Burden
UR  - https://doi.org/10.1016/j.jacr.2020.09.024
ID  - 7793143
ER  - 

TY  - JOUR
AB  - COVID-19 is a global pandemic, thus requiring multiple strategies to develop modalities against it Herein, we designed multiple bioactive small molecules that target a functional structure within the SARS-CoV-2’s RNA genome, the causative agent of COVID-19 An analysis to characterize the structure of the RNA genome provided a revised model of the SARS-CoV-2 frameshifting element, in particular its attenuator hairpin By studying an RNA-focused small molecule collection, we identified a drug-like small molecule (C5) that avidly binds to the revised attenuator hairpin structure with a Kd of 11 nM The compound stabilizes the hairpin’s folded state and impairs frameshifting in cells The ligand was further elaborated into a ribonuclease targeting chimera (RIBOTAC) to recruit a cellular ribonuclease to destroy the viral genome (C5-RIBOTAC) and into a covalent molecule (C5-Chem-CLIP) that validated direct target engagement and demonstrated its specificity for the viral RNA, as compared to highly expressed host mRNAs The RIBOTAC lead optimization strategy improved the bioactivity of the compound at least 10-fold Collectively, these studies demonstrate that the SARS-CoV-2 RNA genome should be considered druggable
AU  - Haniff, Hafeez S.
AU  - Tong, Yuquan
AU  - Liu, Xiaohui
AU  - Chen, Jonathan L.
AU  - Suresh, Blessy M.
AU  - Andrews, Ryan J.
AU  - Peterson, Jake M.
AU  - O’Leary, Collin A.
AU  - Benhamou, Raphael I.
AU  - Moss, Walter N.
AU  - Disney, Matthew D.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders
T2  - ACS Central Science
TI  - Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders
UR  - https://doi.org/10.1021/acscentsci.0c00984
ID  - 7793003
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19) has brought speculations on possible transmission routes of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causal agent of the pandemic. Air pollution has been linked to increased risks of COVID-19 infection and mortality rates in regions with poor air quality, yet no retrospective study has been reported on foodborne transmission of COVID-19. While studies have shown that low temperature could dramatically prolong the persistence on SARS-CoV-2 and other coronaviruses, frozen and refrigerated foods have been widely overlooked as potential vectors in policy frameworks and risk mitigation strategies. Food transmission evidence has been disclosed in China early July 2020 by the detection of SARS-CoV-2 on frozen foods, including their packaging materials and storage environments, with two re-emergent outbreaks linked to contaminated food sources. The contamination risk is augmented by a complex farm-to-table process, which favors exposure to food workers and ambient environments. Moreover, the food cold-chain also promotes contamination because laboratory studies showed that SARS-CoV-2 remained highly stable under refrigerated, at 4 ��C, and freezing conditions, from - 10 to - 80 ��C, on fish, meat, poultry, and swine skin, during 14-21 days. While data are lacking on long-term survival and infectivity under these conditions, ample evidence has been shown on other coronaviruses, including SARS-CoV-1. We therefore hypothesize that contaminated cold-storage foods may present a systematic risk for SARS-CoV-2 transmission between countries and regions. Here, we review the evidence, risk factors, current policy and knowledge gaps, on food contamination and foodborne transmission of SARS-CoV-2.
AD  - Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049 People's Republic of China. GRID: grid.43169.39. ISNI: 0000 0001 0599 1243
Department of Environmental Engineering, College of Earth and Environmental Sciences, Lanzhou University, Lanzhou, 730000 People's Republic of China. GRID: grid.32566.34. ISNI: 0000 0000 8571 0482
AN  - 33024427
AU  - Han, J.
AU  - Zhang, X.
AU  - He, S.
AU  - Jia, P.
C1  - 10/7/2020
C2  - PMC7529092
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s10311-020-01101-x
DP  - NLM
ET  - 2020/10/08
J2  - Environmental chemistry letters
KW  - Cold chain
Coronavirus
Food
Frozen
Logistics
Refrigerated
this work.
LA  - eng
N1  - Han, Jie
Orcid: 0000-0001-6790-0650
Zhang, Xue
He, Shanshan
Jia, Puqi
Journal Article
Review
United States
Environ Chem Lett. 2020 Oct 1:1-12. doi: 10.1007/s10311-020-01101-x.
PY  - 2020
SN  - 1610-3653 (Print)
1610-3653
SP  - 1-12
ST  - Can the coronavirus disease be transmitted from food? A review of evidence, risks, policies and knowledge gaps
T2  - Environmental chemistry letters
TI  - Can the coronavirus disease be transmitted from food? A review of evidence, risks, policies and knowledge gaps
ID  - 7790795
ER  - 

TY  - JOUR
AB  - A small minority are against lockdowns, but the evidence doesn&#039;t support the idea
AU  - Hamzelou, Jessica
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Should we let the virus rip?
T2  - New Scientist
TI  - Should we let the virus rip?
UR  - https://doi.org/10.1016/S0262-4079(20)31733-4
ID  - 7792685
ER  - 

TY  - JOUR
AN  - 33021653
AU  - Hampton, T.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1001/jama.2020.17378
DP  - NLM
ET  - 2020/10/07
IS  - 13
J2  - Jama
LA  - eng
N1  - 1538-3598
Hampton, Tracy
Journal Article
United States
JAMA. 2020 Oct 6;324(13):1274. doi: 10.1001/jama.2020.17378.
PY  - 2020
SN  - 0098-7484
SP  - 1274
ST  - Insight on Sex-Based Immunity Differences, With COVID-19 Implications
T2  - Jama
TI  - Insight on Sex-Based Immunity Differences, With COVID-19 Implications
VL  - 324
ID  - 7791015
ER  - 

TY  - JOUR
AU  - Hammer, Mark M.
AU  - Hunsaker, Andetta R.
AU  - Gooptu, Mahasweta
AU  - Hatabu, Hiroto
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Frequency of Pulmonary Embolism in Patients with COVID-19
T2  - JACC: Cardiovascular Imaging
TI  - Frequency of Pulmonary Embolism in Patients with COVID-19
UR  - https://doi.org/10.1016/j.jcmg.2020.09.006
ID  - 7793137
ER  - 

TY  - JOUR
AU  - Hall, A.
AU  - Chakladar, A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - High fresh gas flow during non-inhalational anaesthetics during the COVID-19 pandemic. Comment on Br J Anaesth 2020
T2  - British Journal of Anaesthesia
TI  - High fresh gas flow during non-inhalational anaesthetics during the COVID-19 pandemic. Comment on Br J Anaesth 2020
UR  - https://doi.org/10.1016/j.bja.2020.09.033
ID  - 7793221
ER  - 

TY  - JOUR
AB  - Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2/2019-nCoV) has spread quickly worldwide, with more than 29 million cases and 920,000 deaths. Interestingly, coronaviruses were found to subvert and hijack the autophagic process to allow their viral replication. One of the spotlights had been focused on the autophagy inhibitors as a target mechanism effective in the inhibition of SARS-CoV-2 infection. Consequently, chloroquine (CQ) and hydroxychloroquine (HCQ), a derivative of CQ, was suggested as the first potentially be therapeutic strategies as they are known to be autophagy inhibitors. Then, they were used as therapeutics in SARS-CoV-2 infection along with remdesivir, for which the FDA approved emergency use authorization. Here, we investigated the antiviral activity and associated mechanism of GNS561, a small basic lipophilic molecule inhibitor of late-stage autophagy, against SARS-CoV-2. Our data indicated that GNS561 showed the highest antiviral effect for two SARS-CoV-2 strains compared to CQ and remdesivir. Focusing on the autophagy mechanism, we showed that GNS561, located in LAMP2-positive lysosomes, together with SARS-CoV-2, blocked autophagy by increasing the size of LC3-II spots and the accumulation of autophagic vacuoles in the cytoplasm with the presence of multilamellar bodies characteristic of a complexed autophagy. Finally, our study revealed that the combination of GNS561 and remdesivir was associated with a strong synergistic antiviral effect against SARS-CoV-2. Overall, our study highlights GNS561 as a powerful drug in SARS-CoV-2 infection and supports that the hypothesis that autophagy inhibitors could be an alternative strategy for SARS-CoV-2 infection.Competing Interest StatementP.H., E.B. and S.M. are Genoscience Pharma Employees.
AU  - Halfon, Philippe
AU  - Bestion, Eloine
AU  - Zandi, Keivan
AU  - Andreani, Julien
AU  - Baudoin, Jean-Pierre
AU  - La Scola, Bernard
AU  - Mege, Jean-Louis
AU  - Mezouar, Soraya
AU  - Schinazi, Raymond F.
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.327635
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.327635
ST  - GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition (preprint)
T2  - bioRxiv
TI  - GNS561 exhibits potent in vitro antiviral activity against SARS-CoV-2 through autophagy inhibition (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.327635.abstract
ID  - 7794721
ER  - 

TY  - JOUR
AB  - Emerging evidence regarding COVID 19 highlights the role of individual resistance and immune function in both susceptibility to infection as well as severity of disease Multiple factors influence the response of the human host when exposed to viral pathogens Influencing an individual’s susceptibility to infection include such factors as nutritional status, physical and psychosocial stressors, obesity, protein calorie malnutrition, emotional resilience, single nucleotide polymorphisms (SNPs), environmental toxins—including air pollution and first- and second-hand tobacco smoke, sleep habits, sedentary lifestyle, drug-induced nutritional deficiencies and drug-induced immunomodulatory effects, availability of nutrient dense food and empty calories This review examines the network of interacting co-factors that influence the host-pathogen relationship, which in turn determine one’s susceptibility to viral infections like COVID 19 It then evaluates the role of machine learning, including predictive analytics and random forest modeling, to help clinicians assess patients�?risk of developing active infection and devise a comprehensive approach to prevention and treatment
AU  - Halamka, John
AU  - Cerrato, Paul
AU  - Perlman, Adam
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Redesigning COVID 19 Care with Network Medicine and Machine Learning: A review
T2  - Mayo Clinic Proceedings: Innovations, Quality & Outcomes
TI  - Redesigning COVID 19 Care with Network Medicine and Machine Learning: A review
UR  - https://doi.org/10.1016/j.mayocpiqo.2020.09.008
ID  - 7793102
ER  - 

TY  - JOUR
AB  - The novel coronavirus, SARS-CoV-2, has infected more than 10 million people and caused more than 502,539 deaths worldwide as of June 2020. The explosive spread of the virus and the rapid increase in the number of cases require the immediate development of effective therapies and vaccines as well as accurate diagnosis tools. The pathogenesis of the disease is triggered by the entry of SARS-CoV-2 via its spike protein into ACE2-bearing host cells, particularly pneumocytes, resulting in overactivation of the immune system, which attacks the infected cells and damages the lung tissue. The interaction of the SARS-CoV-2 receptor binding domain (RBD) with host cells is primarily mediated by the N-terminal helix of ACE2; thus, inhibition of the spike-ACE2 interaction may be a promising therapeutic strategy for blocking the virus entry into host cells. In this paper, we used an in-silico approach to explore small-molecule ��-helix mimetics as inhibitors that may disrupt the attachment of SARS-CoV-2 to ACE2. First, the RBD-ACE2 interface in the 6M0J structure was studied by the MM-GBSA decomposition module of the HawkDock server, which led to the identification of two critical target regions in the RBD. Next, two virtual screening experiments of 7236 ��-helix mimetics from ASINEX were conducted on the above regions using the iDock tool, which resulted in 10 candidates with favorable binding affinities. Finally, the stability of RBD complexes with the top-two ranked compounds was further validated by 100 ns of molecular dynamics simulations. Communicated by Ramaswamy H. Sarma.
AD  - Medical Biotechnology Laboratory (MedBiotech), Bioinova Research Center, Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Rabat, Morocco.
Laboratory of medical parasitology and mycology, Military Hospital Mohammed V, Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Bioinova Research Center, Rabat, Morocco.
Therapeutic Chemistry Laboratory, Medical Biotechnology Laboratory (MedBiotech), Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Rabat, Morocco.
Emergency Department, Military Hospital Mohammed V, Rabat Medical & Pharmacy School, Mohammed Vth University in Rabat, Bioinova Research Center, Rabat, Morocco.
AN  - 33023417
AU  - Hakmi, M.
AU  - Bouricha, E. L. M.
AU  - Akachar, J.
AU  - Lmimouni, B.
AU  - El Harti, J.
AU  - Belyamani, L.
AU  - Ibrahimi, A.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1080/07391102.2020.1830175
DP  - NLM
ET  - 2020/10/08
J2  - Journal of biomolecular structure & dynamics
KW  - Ace2
Covid-19
Coronavirus
MD simulation
Sars-cov-2
spike
treatment
virtual screening
��-helix mimetics
LA  - eng
N1  - 1538-0254
Hakmi, Mohammed
Bouricha, E L Mehdi
Akachar, Jihane
Lmimouni, Badreddine
El Harti, Jaouad
Belyamani, Lahcen
Ibrahimi, Azeddine
Journal Article
England
J Biomol Struct Dyn. 2020 Oct 7:1-12. doi: 10.1080/07391102.2020.1830175.
PY  - 2020
SN  - 0739-1102
SP  - 1-12
ST  - In silico exploration of small-molecule ��-helix mimetics as inhibitors of SARS-COV-2 attachment to ACE2
T2  - Journal of biomolecular structure & dynamics
TI  - In silico exploration of small-molecule ��-helix mimetics as inhibitors of SARS-COV-2 attachment to ACE2
ID  - 7790913
ER  - 

TY  - JOUR
AB  - PURPOSE: Coronavirus disease 2019 (COVID-19) is expected to continue to cause worldwide fatalities until the World population develops 'herd immunity', or until a vaccine is developed and used as a prevention. Meanwhile, there is an urgent need to identify alternative means of antiviral defense. Bacillus Calmette-Guérin (BCG) vaccine that has been recognized for its off-target beneficial effects on the immune system can be exploited to boast immunity and protect from emerging novel viruses. METHODS: We developed and employed a systems biology workflow capable of identifying small-molecule antiviral drugs and vaccines that can boast immunity and affect a wide variety of viral disease pathways to protect from the fatal consequences of emerging viruses. RESULTS: Our analysis demonstrates that BCG vaccine affects the production and maturation of naïve T cells resulting in enhanced, long-lasting trained innate immune responses that can provide protection against novel viruses. We have identified small-molecule BCG mimics, including antiviral drugs such as raltegravir and lopinavir as high confidence hits. Strikingly, our top hits emetine and lopinavir were independently validated by recent experimental findings that these compounds inhibit the growth of SARS-CoV-2 in vitro. CONCLUSIONS: Our results provide systems biology support for using BCG and small-molecule BCG mimics as putative vaccine and drug candidates against emergent viruses including SARS-CoV-2.
AD  - Department of Pharmacy - Computational Chemical Biology, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman, 11733, Jordan. rhajjo@gmail.com.
Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
AN  - 33025261
AU  - Hajjo, R.
AU  - Tropsha, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11095-020-02930-9
DP  - NLM
ET  - 2020/10/08
IS  - 11
J2  - Pharmaceutical research
KW  - BCG vaccine
Covid-19
SARS-CoV-2
innate immunity
systems biology
LA  - eng
N1  - 1573-904x
Hajjo, Rima
Orcid: 0000-0002-7090-5425
Tropsha, Alexander
Orcid: 0000-0003-3802-8896
2020-2019/17/03/Deanship of Academic Research, University of Jordan/
OT2TR003441/NIH Office of the Director/
Journal Article
United States
Pharm Res. 2020 Oct 6;37(11):212. doi: 10.1007/s11095-020-02930-9.
PY  - 2020
SN  - 0724-8741
SP  - 212
ST  - A Systems Biology Workflow for Drug and Vaccine Repurposing: Identifying Small-Molecule BCG Mimics to Reduce or Prevent COVID-19 Mortality
T2  - Pharmaceutical research
TI  - A Systems Biology Workflow for Drug and Vaccine Repurposing: Identifying Small-Molecule BCG Mimics to Reduce or Prevent COVID-19 Mortality
VL  - 37
ID  - 7790716
ER  - 

TY  - JOUR
AB  - There is an urgent need to develop drugs and vaccines to counteract the effects of the new coronavirus SARS-CoV-2 and adequately treat the corona virus disease (COVID-19) As these drugs are still under investigation, research also focuses on existing medication with proven effectiveness in other coronaviral diseases The advantages of existing therapeutic drugs that are currently approved (for other indications) are the known safety profile, general availability and relatively lower costs involved in extending the purpose to a new disease Calcineurin inhibitors (CNI) are drugs that have shown effectiveness in several coronaviral diseases, and are well-known and widely used drugs in transplant medicine The aim of this narrative review is to present the current evidence of CNI in coronaviral diseases, the biophysiology of CNI and to suggest possible ways to study CNI as a new treatment option for COVID-19 We searched original papers, observational studies, case reports, and meta-analyses published between 2000 and 2020 in English in the PubMed database and Google Scholar using the keywords: (coronavirus), (treatment), (MERS), (SARS), (COVID-19), (tacrolimus), (ciclosporin), (cyclosporin) AND (calcineurin inhibitor) We excluded studies in patients with clear indications for immunosuppressive therapy Additionally, we searched in the preprint servers and the World Health Organization bulletin Ten studies were identified and included Calcineurin inhibitor therapy has been suggested to be effective for coronaviral diseases in different settings The results are summarized in a table CNI should be investigated as a first treatment option based on evidence of direct antiviral effects and its properties preventing severe systemic hyperinflammation, as has been observed in COVID-19 with predominantly pulmonary immunopathological changes
AU  - Hage, René Steinack Carolin
AU  - Gautschi, Fiorenza
AU  - Schuurmans, Macé M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Transplant Drugs against SARS, MERS and COVID-19
T2  - Transplantology
TI  - Transplant Drugs against SARS, MERS and COVID-19
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813214
ID  - 7793358
ER  - 

TY  - JOUR
AD  -, Independent Researcher, India. rbiochem@gmail.com.
AN  - 33023646
AU  - Gupta, R.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13054-020-03312-8
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Critical care (London, England)
LA  - eng
N1  - 1466-609x
Gupta, Rahul
Orcid: 0000-0001-8634-2439
Letter
England
Crit Care. 2020 Oct 6;24(1):598. doi: 10.1186/s13054-020-03312-8.
PY  - 2020
SN  - 1364-8535
SP  - 598
ST  - Anakinra: a silver lining in COVID-19?
T2  - Critical care (London, England)
TI  - Anakinra: a silver lining in COVID-19?
VL  - 24
ID  - 7790895
ER  - 

TY  - JOUR
AB  - Advance care directives (ACDs) are instructions regarding what types of medical treatments a patient desires and/or who they would like to designate as a healthcare surrogate to make important healthcare decisions when the patient is mentally incapacitated. At end-of-life, when faced with poor prognosis for a meaningful health-related quality of life, most patients indicate their preference to abstain from aggressive, life-sustaining treatments. Patients whose wishes are left unsaid often receive burdensome life sustain therapy by default, prolonging patient suffering. The CoVID pandemic has strained our healthcare resources and raised the need for prioritization of life-sustaining therapy. This highlights the urgency of ACDs more than ever. Despite ACDs' potential to provide patients with care that aligns with their values and preferences and reduce resource competition, there has been relatively little conversation regarding the overlap of ACDs and CoVID-19. There is low uptake among patients, lack of training for healthcare professionals, and inequitable adoption in vulnerable populations. However, solutions are forthcoming and may include electronic medical record completion, patient outreach efforts, healthcare worker programs to increase awareness of at-risk minority patients, and restructuring of incentives and reimbursement policies. This review carefully describes the above challenges and unique opportunities to address them in the CoVID-19 era. If solutions are leveraged appropriately, ACDs have the potential to address the described challenges and ethically resolve resource conflicts during the current crisis and beyond.
AD  - The Brooklyn Hospital Center, NY, USA.
University at Buffalo, NY, USA.
University of Texas Health Sciences Center, Houston, TX, USA.
UNC School of Medicine, Chapel Hill, NC, USA.
AN  - 33021094
AU  - Gupta, A.
AU  - Bahl, B.
AU  - Rabadi, S.
AU  - Mebane, A., 3rd
AU  - Levey, R.
AU  - Vasudevan, V.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/1049909120963698
DP  - NLM
ET  - 2020/10/07
J2  - The American journal of hospice & palliative care
KW  - Covid-19
advance care planning
advance directives
critical illness
documentation
severe acute respiratory syndrome coronavirus 2
terminal care
LA  - eng
N1  - 1938-2715
Gupta, Amol
Orcid: 0000-0001-8307-4192
Bahl, Bhavyaa
Rabadi, Saher
Mebane, Alexander 3rd
Levey, Robert
Vasudevan, Viswanath
Journal Article
United States
Am J Hosp Palliat Care. 2020 Oct 6:1049909120963698. doi: 10.1177/1049909120963698.
PY  - 2020
SN  - 1049-9091
SP  - 1049909120963698
ST  - Value of Advance Care Directives for Patients With Serious Illness in the Era of COVID Pandemic: A Review of Challenges and Solutions
T2  - American journal of hospice & palliative care
TI  - Value of Advance Care Directives for Patients With Serious Illness in the Era of COVID Pandemic: A Review of Challenges and Solutions
ID  - 7791051
ER  - 

TY  - JOUR
AB  - Purpose: The COVID-19 pandemic posed an unprecedented challenge to healthcare systems around the world. To mitigate the risks of those referred with possible colorectal cancer during the pandemic we implemented a clinical pathway which required a customised data management system for robust operation. Here, we describe the principal concepts and evaluation of the performance of a spreadsheet-based data management system. Methods: A system was developed using Microsoft Excel 2007 aiming to retain the spreadsheets inherent intuitiveness of direct data entry. Data was itemised limiting entry errors. Visual Basic for Applications (VBA) was used to construct a user-friendly interface to enhance efficiency of data entry and segregate the data required for operational tasks. This was done with built-in loop-back data entry. Finally data derivation and analysis was performed to facilitate pathway monitoring. Results: For a pathway which required rapid implementation and development of a customised data management system, the use of a spreadsheet was advantageous due to its user-friendly direct data entry capability. Its function was enhanced by UserForm and large data handling by data segregation using VBA macros. Data validation and conditional formatting minimised data entry errors. Computation by the COUNT function facilitated live data monitoring on a dashboard. During the three months the pathway ran for, the system processed 36 nodal data points for each of the included 837 patients. Data monitoring confirmed its accuracy. Conclusion: Large volume data management using a spreadsheet system is possible with appropriate data definition and VBA programmed data segregation. Regular input and optimisation by clinicians made the system adaptable for rapid implementation.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNoneAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was an audit and did not require specific IRB approvalAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAvailability of data and material: A data cleaned file is available as a reference Code availability: Available if contacted
AU  - Gunn, Frances
AU  - Miller, Janice
AU  - Dunlop, Malcolm G.
AU  - Din, Farhat V. N.
AU  - Maeda, Yasuko
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206920
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206920
ST  - Development of a customised data management system for a COVID-19-adapted colorectal cancer pathway (preprint)
T2  - medRxiv
TI  - Development of a customised data management system for a COVID-19-adapted colorectal cancer pathway (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206920.abstract
ID  - 7794760
ER  - 

TY  - JOUR
AB  - The pandemic of coronavirus disease (COVID-19), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is causing high and rapid morbidity and mortality. Immune system response plays a crucial role in controlling and resolving the viral infection. Exogenous or endogenous glucocorticoid excess is characterized by increased susceptibility to infections, due to impairment of the innate and adaptive immune system. In addition, diabetes, hypertension, obesity and thromboembolism are conditions overrepresented in patients with hypercortisolism. Thus patients with chronic glucocorticoid (GC) excess may be at high risk of developing COVID-19 infection with a severe clinical course. Care and control of all comorbidities should be one of the primary goals in patients with hypercortisolism requiring immediate and aggressive treatment. The European Society of Endocrinology (ESE), has recently commissioned an urgent clinical guidance document on management of Cushing's syndrome in a COVID-19 period. In this review, we aim to discuss and expand some clinical points related to GC excess that may have an impact on COVID-19 infection, in terms of both contagion risk and clinical outcome. This document is addressed to all specialists who approach patients with endogenous or exogenous GC excess and COVID-19 infection.
AD  - Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", UOC di Malattie endocrine, del Ricambio e della Nutrizione, Università degli studi di Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy.
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Via Sergio Pansini 5, 80131, Naples, Italy.
Clinica di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Cliniche e Molecolari (DISCLIMO), Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Via Conca 71, 60126, Ancona, Italy.
Endocrinology Unit, Department of Medicine, DIME University-Hospital of Padova, Padua, Italy.
Department of Experimental Medicine, Policlinico Umberto I, COVID Hospital, Sapienza University of Rome, 00161, Rome, Italy.
Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", UO di Reumatologia, Università degli studi di Palermo, Palermo, Italy.
Clinica di Endocrinologia e Malattie del Metabolismo, Dipartimento di Scienze Cliniche e Molecolari (DISCLIMO), Università Politecnica delle Marche, Ospedali Riuniti di Ancona, Via Conca 71, 60126, Ancona, Italy. gioarnaldi@gmail.com.
Dipartimento di Medicina Clinica e Chirurgia, Sezione di Endocrinologia, Università Federico II di Napoli, Via Sergio Pansini 5, 80131, Naples, Italy. rosario.pivonello@unina.it.
Dipartimento di Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro", UOC di Malattie endocrine, del Ricambio e della Nutrizione, Università degli studi di Palermo, Piazza delle Cliniche 2, 90127, Palermo, Italy. carla.giordano@unipa.it.
AN  - 33025384
AU  - Guarnotta, V.
AU  - Ferrigno, R.
AU  - Martino, M.
AU  - Barbot, M.
AU  - Isidori, A. M.
AU  - Scaroni, C.
AU  - Ferrante, A.
AU  - Arnaldi, G.
AU  - Pivonello, R.
AU  - Giordano, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11154-020-09598-x
DP  - NLM
ET  - 2020/10/08
J2  - Reviews in endocrine & metabolic disorders
KW  - Cortisol
Cushing’s syndrome
Glucocorticoid
Immune system
Infections
SarsCoV2
LA  - eng
N1  - 1573-2606
Guarnotta, Valentina
Orcid: 0000-0002-8088-4947
Ferrigno, Rosario
Martino, Marianna
Barbot, Mattia
Isidori, Andrea M
Orcid: 0000-0002-9037-5417
Scaroni, Carla
Orcid: 0000-0001-9396-3815
Ferrante, Angelo
Orcid: 0000-0002-5807-1181
Arnaldi, Giorgio
Pivonello, Rosario
Giordano, Carla
Orcid: 0000-0003-1731-9395
Journal Article
Review
Germany
Rev Endocr Metab Disord. 2020 Oct 6. doi: 10.1007/s11154-020-09598-x.
PY  - 2020
SN  - 1389-9155
ST  - Glucocorticoid excess and COVID-19 disease
T2  - Reviews in endocrine & metabolic disorders
TI  - Glucocorticoid excess and COVID-19 disease
ID  - 7790710
ER  - 

TY  - JOUR
AB  - An extension of the classical pandemic SIRD model is considered for the regional spread of COVID-19 in France under lockdown strategies This compartment model divides the infected and the recovered individuals into undetected and detected compartments respectively By fitting the extended model to the real detected data during the lockdown, an optimization algorithm is used to derive the optimal parameters, the initial condition and the epidemics start date of regions in France Considering all the age classes together, a network model of the pandemic transport between regions in France is presented on the basis of the regional extended model and is simulated to reveal the transport effect of COVID-19 pandemic after lockdown Using the measured values of displacement of people between cities, the pandemic network of all cities in France is simulated by using the same model and method as the pandemic network of regions Finally, a discussion on an integro-differential equation is given and a new model for the network pandemic model of each age class is provided
AU  - Guan, Lina
AU  - Prieur, Christophe
AU  - Zhang, Liguo
AU  - Prieur, Clémentine Georges
AU  - Didier, Bellemain
AU  - Pascal
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Transport effect of COVID-19 pandemic in France
T2  - Annual Reviews in Control
TI  - Transport effect of COVID-19 pandemic in France
UR  - https://doi.org/10.1016/j.arcontrol.2020.09.009
ID  - 7793228
ER  - 

TY  - JOUR
AB  - Aim The COVID-19 pandemic may influence the willingness of bystanders to engage in resuscitation for out-of-hospital cardiac arrest We sought to determine if and how the pandemic has changed willingness to intervene, and the impact of personal protective equipment (PPE) Methods We distributed a 12-item survey to the general public through social media channels from June 4 to 23, 2020 We used 100-point scales to inquire about participants�?willingness to perform interventions on “strangers or unfamiliar persons�?and “family members or familiar persons�? and compared mean willingness during time periods prior to and during the COVID-19 pandemic using paired t-tests Results Survey participants (n=1360) were from 26 countries;the median age was 38 years (IQR 24-50) and 45% were female Compared to prior to the pandemic, there were significant decreases in willingness to check for breathing or a pulse (mean difference -10 7% [95% CI -11 8, -9 6] for stranger/unfamiliar persons, -1 2% [95% CI -1 6, -0 8] for family/familiar persons), perform chest compressions (-14 3% [95% CI -15 6, -13 0], -1 6% [95% CI -2 1, -1 1]), provide rescue breaths (-19 5% [95% CI -20 9, -18 1], -5 5% [95% CI -6 4, -4 6]), and apply an automated external defibrillator (-4 8% [95% CI -5 7, -4 0], -0 9% [95% CI -1 3, -0 5]) during the COVID-19 pandemic Willingness to intervene increased significantly if PPE was available (+8 3% [95% CI 7 2,9 5] for stranger/unfamiliar, and +1 4% [95% CI 0 8, 1 9] for family/familiar persons) Conclusion Willingness to perform bystander resuscitation during the pandemic decreased, however this was ameliorated if simple PPE were available
AU  - Grunau, Brian
AU  - Bal, Joban
AU  - Scheuermeyer, Frank
AU  - Guh, Daphne
AU  - Dainty, Katie N.
AU  - Helmer, Jennie
AU  - Saini, Sumeet
AU  - Chakrabarti, Adrija
AU  - Brar, Noor
AU  - Sidhu, Nimrit
AU  - Barbic, David
AU  - Christenson, Jim
AU  - Chakrabarti, Santabhanu
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Bystanders are less willing to resuscitate out-of-hospital cardiac arrest victims during the COVID-19 pandemic
T2  - Resuscitation Plus
TI  - Bystanders are less willing to resuscitate out-of-hospital cardiac arrest victims during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.resplu.2020.100034
ID  - 7793061
ER  - 

TY  - GEN
AN  - NCT04578132
AU  - Group, Spanish Oncology Genito-Urinary
C1  - 10/7/2020
DA  - September 30
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19|Genito Urinary Cancer
N1  - No Results Available
Baseline characteristics|Frequency of complications of COVID-19 intercurrent infection|Frequency of complications of COVID-19 infection in patients stratified by oncological treatment|Frequency of adverse events related to immunotherapy targeted to cancer (classified by type and severity)|Frequency of complications of COVID-19 infection in patients with prostate cancer stratified by anti-androgenic oncological treatment|COVID-19 mortality rate in patients with genitourinary cancer|COVID-19 complication rate in patients with genitourinary cancer|Asymptomatic rate|Frequency of delays/modifications on cancer treatment schedule|Progression free survival in patients with genitourinary tumors that suffered COVID-19|Overall survival in patients with genitourinary tumors that suffered COVID-19
All
250
Other
Observational Model: Ecologic or Community|Time Perspective: Other
SOG-INM-2020-04
October 2021
PB  - https://ClinicalTrials.gov/show/NCT04578132
PY  - 2020
ST  - sogugcovid
T2  - ClinicalTrials
TI  - Description of the Population With Genitourinary Tumors and COVID-19
UR  - https://ClinicalTrials.gov/show/NCT04578132
ID  - 7794699
ER  - 

TY  - JOUR
AB  - BACKGROUND: Limited data are available regarding antiviral therapy efficacy in most severe patients under mechanical ventilation for Covid-19-related acute respiratory distress syndrome (ARDS). METHODS: Comparison of antiviral strategies (none, hydroxychloroquine (OHQ), lopinavir/ritonavir (L/R), others (combination or remdesivir) in an observational multicentre cohort of patients with moderate-to-severe Covid-19 ARDS. The primary endpoint was the number of day 28 ventilator-free days (VFD). Patients who died before d28 were considered as having 0 VFD. The variable was dichotomized into "patients still ventilated or dead at day 28" versus "patients weaned and alive at day 28". RESULTS: We analyzed 415 patients (85 treated with standard of care (SOC), 57 with L/R, 220 with OHQ, and 53 others). The median number of d28-VFD was 0 (IQR 0-13) and differed between groups (P�?�?.03), SOC patients having the highest d28-VFD. After adjustment for age, sex, Charlson Comorbidity Index, PaO(2)/FiO(2) ratio and plateau pressure and accounting for center effect with a generalized linear mixed model, none of the antiviral strategies increased the chance of being alive and weaned from MV at day 28 compared to the SOC strategy (OR 0.48 CI95% (0.18-1.25); OR 0.96 (0.47-2.02) and OR 1.43 (0.53-4.04) for L/R, OHQ and other treatments, respectively). Acute kidney injury during ICU stay was frequent (55%); its incidence was higher in patients receiving lopinavir (66 vs 53%, P�?�?.03). After adjustment for age, sex, BMI, chronic hypertension and chronic renal disease, the use of L/R was associated with an increased risk of renal replacement therapy (RRT). (OR 2.52 CI95% 1.16-5.59). CONCLUSION: In this multicentre observational study of moderate-to-severe Covid-19 ARDS patients, we did not observe any benefit among patients treated with OHQ or L/R compared with SOC. The use of L/R treatment was associated with an increased need for RRT. Take home message Neither hydroxychloroquine nor lopinavir/ritonavir as COVID-19 antiviral treatment is associated with higher ventilator-free days at day 28 when compared with standard of care (no antiviral treatment) in ICU patients under invasive mechanical ventilation. Lopinavir/ritonavir is associated with an increased risk of renal replacement therapy requirement. Tweet COVID-19: Insights from ARDS cohort: no signal of efficacy of any antiviral drugs. Lopinavir/ritonavir may be associated with need for RRT.
AD  - Soins IntensifsHôpital Erasme, ULB, Route de Lennik 808, 1070, Bruxelles, Belgium. david.grimaldi@erasme.ulb.ac.be.
Medecine Intensive Reanimation, Hôpital Européen Georges Pompidou, Paris centre U 970 PARCC, Paris, France.
District Hospital Center, Boulevard Stephane Moreau, Medecine Intensive Reanimation, 85000, La Roche Sur Yon, France.
Unité de Soins Intensifs, CHR Mons-Hainaut, Mons, Belgium.
Unité de Soins Intensifs, Centres Hospitaliers de Jolimont, La Louvi؈re, Belgium.
Réanimation médico-Chirurgicale CHU Avicennes, Université Sorbonne Paris Nord, Bobigny, France.
Plateforme de Méthodologie Et Biostatistique, CHU Nantes, 1 Places Alexis Ricordeau, 44093, Nantes Cedex 9, France.
Unité de Soins Intensifs, CHU Ambroise Paré, Mons, Belgium.
Unité de Soins Intensifs, CHU Dinant Godinne, site Dinant, Dinant, Belgium.
Unité de Soins Intensifs, CHU Dinant Godinne, site Godinne, Godinne, Belgium.
Médecine Intensive Réanimation, Assistance Publique - Hôpitaux de Marseille, Hôpital Nord, 13015, Marseille, France.
Centre D'Etudes Et de Recherches Sur Les Services de Santé Et qualité de Vie EA 3279, Aix- Faculté de médecine, Marseille Université, 13005, Marseille, France.
Réanimation Polyvalente Centre Hospitalier du Pays D'Aix, Aix en Provence, France.
Unité de Soins Intensifs, Clinique Notre Dame de Grâce, Gosselies, Belgium.
Service d'anesthésie-réanimation chirurgicale Unité de réanimation chirurgicale polyvalente, Hôpitaux Universitaires Henri Mondor, Créteil, France.
Intensive Care. CHU-Charleroi, Marie Curie, Université Libre de Bruxelles, 140, chaussée de Bruxelles, 6042, Charleroi, Belgium.
Réanimation - Médecine Intensive, Centre Hospitalier Public du Cotentin, BP208, 50102, Cherbourg-en-Cotentin, France.
Unité de soins intensifs, Clinique Saint Pierre, Ottignies, Belgium.
Médecine Intensive Réanimation, CHU Besançon, 3 Boulevard FLEMING, 25030, Besançon, France.
Médecine Intensive Réanimation, CHRU Tours, Tours, France.
INSERM CIC 1415, CHRU Tours, Tours, France.
CRICS-TriggerSEP research network, Tours, France.
Service de réanimation, Hospices Civils de Lyon, 5 Place D'Arsonval, Lyon, France.
Laboratoire Commun de Recherche bioMérieux-Hospices Civils de Lyon-Université de Lyon 1, EA7426 PI3, Lyon, France.
Groupe des anesthésistes réanimateurs, Hôpital Privé d'Antony, Antony, France.
Service de Médecine Intensive Réanimation Unité de Sevrage Ventilatoire et Réhabilitation Centre Hospitalier de BETHUNE, 27 Rue Delbecque, 62660, Beuvry, France.
Medecine Intensive Reanimation, CHU Nantes, 30 Boulevard Jean Monnet, 44093, Nantes Cedex 9, France.
AN  - 33025225
AU  - Grimaldi, D.
AU  - Aissaoui, N.
AU  - Blonz, G.
AU  - Carbutti, G.
AU  - Courcelle, R.
AU  - Gaudry, S.
AU  - Gaultier, A.
AU  - D'Hondt, A.
AU  - Higny, J.
AU  - Horlait, G.
AU  - Hraiech, S.
AU  - Lefebvre, L.
AU  - Lejeune, F.
AU  - Ly, A.
AU  - Piagnerelli, M.
AU  - Sauneuf, B.
AU  - Serck, N.
AU  - Soumagne, T.
AU  - Szychowiak, P.
AU  - Textoris, J.
AU  - Vandenbunder, B.
AU  - Vinsonneau, C.
AU  - Lascarrou, J. B.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13613-020-00751-y
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Annals of intensive care
KW  - Acute kidney injury
Hydroxychloroquine
Lopinavir
Remdesivir
Renal replacement therapy
Ritonavir
LA  - eng
N1  - Grimaldi, David
Orcid: 0000-0001-8428-065x
Aissaoui, Nadia
Blonz, Gauthier
Carbutti, Giuseppe
Courcelle, Romain
Gaudry, Stephane
Gaultier, Aurelie
D'hondt, Alain
Higny, Julien
Horlait, Geoffrey
Hraiech, Sami
Lefebvre, Laurent
Lejeune, Francois
Ly, Andre
Piagnerelli, Michael
Sauneuf, Bertrand
Serck, Nicolas
Soumagne, Thibaud
Szychowiak, Piotr
Textoris, Julien
Vandenbunder, Benoit
Vinsonneau, Christophe
Lascarrou, Jean- Baptiste
COVADIS study group
Journal Article
Germany
Ann Intensive Care. 2020 Oct 6;10(1):131. doi: 10.1186/s13613-020-00751-y.
PY  - 2020
SN  - 2110-5820 (Print)
2110-5820
SP  - 131
ST  - Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study
T2  - Annals of intensive care
TI  - Characteristics and outcomes of acute respiratory distress syndrome related to COVID-19 in Belgian and French intensive care units according to antiviral strategies: the COVADIS multicentre observational study
VL  - 10
ID  - 7790717
ER  - 

TY  - JOUR
AB  - Background Interleukin-6 signal blockade showed preliminary beneficial effects in treating inflammatory response against SARS-CoV-2 leading to severe respiratory distress Herein we describe the outcomes of off-label intravenous use of Sarilumab in severe SARS-CoV-2-related pneumonia Methods 53 patients with SARS-CoV-2 severe pneumonia received intravenous Sarilumab;pulmonary function improvement or Intensive Care Unit (ICU) admission rate in medical wards, live discharge rate in ICU treated patients and safety profile were recorded Sarilumab 400 mg was administered intravenously on day 1, with eventual additional infusion based on clinical judgement, and patients were followed for at least 14 days, unless previously discharged or dead Findings Of the 53 SARS-CoV-2pos patients receiving Sarilumab, 39(73·6%) were treated in medical wards [66·7% with a single infusion;median PaO2/FiO2:146(IQR:120�?12)] while 14(26·4%) in ICU [92·6% with a second infusion;median PaO2/FiO2: 112(IQR:100�?41 5)] Within the medical wards, 7(17·9%) required ICU admission, 4 of whom were re-admitted to the ward within 5�? days At 19 days median follow-up, 89·7% of medical inpatients significantly improved (46·1% after 24 h, 61·5% after 3 days), 70·6% were discharged from the hospital and 85·7% no longer needed oxygen therapy Within patients receiving Sarilumab in ICU, 64·2% were discharged from ICU to the ward and 35·8% were still alive at the last follow-up Overall mortality rate was 5·7% Interpretation
AU  - Gremese, Elisa
AU  - Cingolani, Antonella
AU  - Bosello, Silvia Laura
AU  - Alivernini, Stefano
AU  - Tolusso, Barbara
AU  - Perniola, Simone
AU  - Landi, Francesco
AU  - Pompili, Maurizio
AU  - Murri, Rita
AU  - Santoliquido, Angelo
AU  - Garcovich, Matteo
AU  - Sali, Michela
AU  - De Pascale, Gennaro
AU  - Gabrielli, Maurizio
AU  - Biscetti, Federico
AU  - Montalto, Massimo
AU  - Tosoni, Alberto
AU  - Gambassi, Giovanni
AU  - Rapaccini, Gian Ludovico
AU  - Iaconelli, Amerigo
AU  - Zileri Del Verme, Lorenzo
AU  - Petricca, Luca
AU  - Fedele, Anna Laura
AU  - Lizzio, Marco Maria
AU  - Tamburrini, Enrica
AU  - Natalello, Gerlando
AU  - Gigante, Laura
AU  - Bruno, Dario
AU  - Verardi, Lucrezia
AU  - Taddei, Eleonora
AU  - Calabrese, Angelo
AU  - Lombardi, Francesco
AU  - Bernabei, Roberto
AU  - Cauda, Roberto
AU  - Franceschi, Francesco
AU  - Landolfi, Raffaele
AU  - Richeldi, Luca
AU  - Sanguinetti, Maurizio
AU  - Fantoni, Massimo
AU  - Antonelli, Massimo
AU  - Gasbarrini, Antonio
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Sarilumab use in severe SARS-CoV-2 pneumonia
T2  - EClinicalMedicine
TI  - Sarilumab use in severe SARS-CoV-2 pneumonia
UR  - https://doi.org/10.1016/j.eclinm.2020.100553
ID  - 7793187
ER  - 

TY  - JOUR
AB  - COVID-19 remains pandemic at the time of writing (September 2020) and it has opened up many avenues of research, on itself and on other aspects of medicine and science This collection of Best Practice Guidelines (BPG) and the one following will review various aspects of COVID-19 Two papers review schools: reported clusters to date globally and the specific preparations made by one specific Maltese school to try to avoid/dampen any outbreaks in the school Some economic aspects are also reviewed including the effects of the second wave on tourism revenues in Malta and a clarification of how (carefully) raising lockdowns is crucial to revive devastated economies Three papers deal with statistics;estimating delay to death from surges of cases, demonstrating the second wave globally and by continent, and finally estimating the risk of rare and severe hypothetical adverse events after a vaccine has undergone standard testing and compares this to estimated death rate/s from COVID-19 The results of an influenza and COVID-19 vaccine hesitancy questionnaire in Malta&#039;s healthcare workers are also depicted One general review reiterates that COVID-19 is ageist, sexist, ruthless, dispassionate and opportunistic, and that protecting our vulnerable while easing restrictions remains crucial Another review recaps the increased importance of less influenza vaccine hesitancy and less presenteeism among health care workers next winter We dedicate this BPG to the ill and to the fallen
AU  - Grech, Victor
AU  - Cuschieri, Sarah
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Novel research opportunities: An unfortunate small silver lining to COVID-19
T2  - Early Human Development
TI  - Novel research opportunities: An unfortunate small silver lining to COVID-19
UR  - https://doi.org/10.1016/j.earlhumdev.2020.105205
ID  - 7793189
ER  - 

TY  - JOUR
AB  - Introduction COVID-19 is pandemic International travel bans in March 2020 dampened viral spread and resulted in an overnight global economic crisis As countries ease travel and social distancing restrictions, viral resurgences are expected This study was carried out in order to delineate the development of a second wave of COVID-19 cases and deaths due to lockdown easements in June–July 2020 Methods Publically available data for daily new cases and deaths from December 2019 to September 2020 was obtained from “Our World In Data�?website and analysed with Pearson correlation Results At global level, both datasets exhibited three distinct time periods Cases rose to mid-April, plateaued till mid-May then rose again Almost all of the slopes in these three time periods were statistically significant Deaths followed a similar three-part pattern, albeit more pronounced, with values lagging circa one week after new cases and a middle time period when numbers (of deaths) actually decreased, with all periods exhibiting significant slopes At continent level, for new cases, Asia rose steadily, Europe is increasing again, the Americas and Africa are declining Deaths follow a similar pattern Oceania shows a bimodal pattern, with a first and second wave of cases shortly followed by deaths in a similar pattern The monthly ratio of detected cases to deaths (case fatality ratio) initially rose to 0 08, then fell to 0 02 Conclusion The world is in its second wave of COVID-19, with fortunately reduced case fatality ratios
AU  - Grech, Victor
AU  - Cuschieri, Sarah
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19: A global and continental overview of the second wave and its (relatively) attenuated case fatality ratio
T2  - Early Human Development
TI  - COVID-19: A global and continental overview of the second wave and its (relatively) attenuated case fatality ratio
UR  - https://doi.org/10.1016/j.earlhumdev.2020.105211
ID  - 7793188
ER  - 

TY  - JOUR
AB  - Introduction The coronavirus outbreak has set off alarms around the world, leading to border closures, trade controls, travel bans and other measures The Wuhan coronavirus epidemic continues to spread globally to the new European hotspot in Italy New information about the epidemic and the virus is changing rapidly as the virus spreads and appears in parts of the world Although official announcements by the Croatian Government and Crisis Staff calmed the public with pictures and data on the disease, it showed something else that heightened public concern and caused two conflicting phenomena among citizens - on the one hand, the majority showed understandable doubt about the information that could have raised the concern for their own health while the rest of the population ignored the facts The market showed complete unwillingness to cope with this epidemic and a chronic shortage of protective equipment (masks, disinfectants ) emerged Most of the citizens&#039; queries and concerns were moving in the direction of personal protection, child protection and justification for holding large gatherings Results By March 8, 2020, twelve COVID-19 patients were recorded in Croatia, of which 5 were patients in Rijeka, 3 in Zagreb and 4 in VaraÅ¾din The first sick person is a Croatian citizen from Zagreb who became infected during his stay in Italy (Milan, Lombardy province) Conclusions In this crisis, several basic principles of crisis communication with the public have been forgotten: The first source of communication often becomes the source against which everyone else is measured Accuracy is crucial to credibility Emotion cannot be countered by facts People must first know that the government cares The public should regain a sense of control over circumstances beyond control A lack of public respect in a crisis undermines trust Honesty is fundamental to maintaining trust Key messages Accuracy is crucial to credibility Emotion cannot be countered by facts
AU  - Grbic, M.
AU  - Grbic, D. Stimac
AU  - Stimac, L.
AU  - Sostar, Z.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Coronavirus - Crisis Communication in Croatia
T2  - European Journal of Public Health
TI  - Coronavirus - Crisis Communication in Croatia
UR  - https://doi.org/10.1093/eurpub/ckaa165.063
ID  - 7792920
ER  - 

TY  - JOUR
AD  - Lawrence O. Gostin, J.D., LL.D. (Hon.), is University Professor at Georgetown University and the Founding Linda D. & Timothy J. O'Neill Professor of Global Health Law at Georgetown University Law Center and Director of the World Health Organization Center on National and Global Health Law. Safura Abdool Karim, LL.B., LL.M., is a senior researcher at the SAMRC Centre for Health Economics and Decision Science - PRICELESS SA at the Wits School of Public Health. Benjamin Mason Meier, J.D., LL.M., Ph.D., is an Associate Professor of Global Health Policy at the University of North Carolina at Chapel Hill and a Scholar at the O'Neill Institute for National and Global Health Law.
AN  - 33021168
AU  - Gostin, L. O.
AU  - Karim, S. A.
AU  - Mason Meier, B.
C1  - 10/7/2020
DA  - Sep
DB  - PubMed
DO  - 10.1177/1073110520958892
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
LA  - eng
N1  - 1748-720x
Gostin, Lawrence O
Karim, Safura Abdool
Mason Meier, Benjamin
Journal Article
United States
J Law Med Ethics. 2020 Sep;48(3):622-626. doi: 10.1177/1073110520958892.
PY  - 2020
SN  - 1073-1105
SP  - 622-626
ST  - Facilitating Access to a COVID-19 Vaccine through Global Health Law
T2  - Journal of law, medicine & ethics : a journal of American Society of Law, Medicine & Ethics
TI  - Facilitating Access to a COVID-19 Vaccine through Global Health Law
VL  - 48
ID  - 7791046
ER  - 

TY  - JOUR
AB  - On 31 December 2019, health authorities in the People&#039;s Republic of China informed the World Health Organization of a then limited outbreak of interstitial viral pneumonia, identified at a laboratory in the city of Wuhan In mid-April 2020 this outbreak of COVID-19 (as the disease has been called) has aggravated and spread worldwide, causing more than 200,000 deaths and affecting especially the United States, Spain, Italy, France and the United Kingdom Despite the severity of the outbreak, the pathological findings have not been described in detail and there are very few guidelines or protocols for conducting autopsy studies on patients who have died from COVID-19 There are currently very few histopathological case series studies on this disease In addition, some of these studies have been performed on biopsies or surgical resection pieces from patients in whom disease was subsequently demonstrated or through minimally invasive autopsy protocols None of the studies offer a detailed necropsy protocol This document proposes a protocol of action for the institutes of Forensic Medicine facing the current SARS-CoV2 pandemic, which combines protection of worker safety with optimization of tissue collection
AU  - Gonz֙lez-Arnay, Emilio
AU  - Mart�Tn-Olivera, Raquel
AU  - Quintero-Quintero, Yamilet C.
AU  - Hern֙ndez-Guerra, Ana I.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Proposal for a harmonized protocol for COVID-19 screening and necropsy in forensic sciences facilities
T2  - Journal of Forensic and Legal Medicine
TI  - Proposal for a harmonized protocol for COVID-19 screening and necropsy in forensic sciences facilities
UR  - https://doi.org/10.1016/j.jflm.2020.102067
ID  - 7793133
ER  - 

TY  - JOUR
AD  - Public Health Modeling Unit and Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA gregg.gonsalves@yale.edu.
Center for Policy Impact in Global Health, Duke Global Health Institute, Duke University, Durham, NC, USA.
AN  - 33023874
AU  - Gonsalves, G.
AU  - Yamey, G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/bmj.m3878
DP  - NLM
ET  - 2020/10/08
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Gonsalves, Gregg
Yamey, Gavin
Editorial
England
BMJ. 2020 Oct 6;371:m3878. doi: 10.1136/bmj.m3878.
PY  - 2020
SN  - 0959-8138
SP  - m3878
ST  - Political interference in public health science during covid-19
T2  - BMJ
TI  - Political interference in public health science during covid-19
VL  - 371
ID  - 7790870
ER  - 

TY  - JOUR
AB  - As with many other infectious and chronic conditions, the COVID-19 crisis in the United States (U S ) reveals severe inequities in health The objective of this study was to describe public perceptions of disparities in mortality from COVID-19 and examine correlates of those perceptions We fielded a nationally-representative survey in late April 2020, asking participants how much they agreed with four statements describing group-level COVID-19 disparities: older people compared to younger, people with chronic health conditions compared to those without, poorer people compared to wealthier, and Black people compared to white people We also measured personal characteristics, experience with COVID-19, and information sources Overall agreement with age- and health condition-related disparities was high (&amp;gt;80%) while agreement with socioeconomic (SES) and racial disparities was lower (52%) Higher education and income were generally associated with greater agreement with disparities Partisanship and information sources used were associated with perceptions of SES- and racial-disparities, with Democrats and those attune to national news—but not Fox cable news—more likely to perceive these disparities As of April 2020, information about age- and health condition-related disparities in COVID-19 was well known by the U S public, while information about social disparities was less recognized and varied along socioeconomic and partisan lines
AU  - Gollust, Sarah E.
AU  - Vogel, Rachel I.
AU  - Rothman, Alexander
AU  - Yzer, Marco
AU  - Fowler, Erika Franklin
AU  - Nagler, Rebekah H.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Americans' perceptions of disparities in COVID-19 mortality: Results from a nationally-representative survey
T2  - Preventive Medicine
TI  - Americans' perceptions of disparities in COVID-19 mortality: Results from a nationally-representative survey
UR  - https://doi.org/10.1016/j.ypmed.2020.106278
ID  - 7793034
ER  - 

TY  - JOUR
AU  - Goldstein, N. D.
AU  - Wheeler, D. C.
AU  - Gustafson, P.
AU  - Burstyn, I.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Improving Spatial Estimates for COVID-19 Using Surveillance Data in Philadelphia
T2  - Annals of Epidemiology
TI  - Improving Spatial Estimates for COVID-19 Using Surveillance Data in Philadelphia
UR  - https://doi.org/10.1016/j.annepidem.2020.08.050
ID  - 7793232
ER  - 

TY  - JOUR
AB  - Purpose To determine predictors associated with caregivers�?willingness to accept an accelerated regulatory process for Coronavirus disease 2019 (COVID-19) vaccine development Methods An international cross-sectional survey of 2557 caregivers arriving with their children to 17 pediatric Emergency Departments (ED) across six countries from March 26 to June 30, 2020 Caregivers were asked to select one of four choices they agreed with the most regarding a proposed COVID-19 vaccine approval process, in addition to questions regarding demographics, the ED visit, and attitudes about COVID-19 Univariate analyses were conducted using the Mann-Whitney test for comparing non-normal continuous variables, independent t-test for comparing normally distributed continuous variables, and Chi-square or Fisher’s exact test for categorical variables Variables of interest subsequently underwent a multivariable logistic regression analysis to determine independent factors associated with caregivers�?willingness to accept abridged COVID-19 vaccine development A p-value less than 0 05 was considered significant Findings Almost half (1101/2557;43%) of caregivers reported that they are willing to accept less rigorous testing and post-research approval for a new COVID-19 vaccine Independent factors associated with willingness to expedite COVID-19 vaccine research included children that were up-to-date on their vaccination schedule (Odds Ratio (OR) = 1 72, 95% Confidence Interval (CI) = 1 29-2 31), caregivers concerned that they had COVID-19 at the time of survey completion in the ED (OR = 1 1, 95% CI 1 05-1 16), and caregivers that intend to vaccinate their children against COVID-19 if a vaccine becomes available (OR = 1 84, 95% CI 1 54-2 21) Mothers completing the survey were less likely to approve changes in the vaccine development process (OR = 0 64, 95% CI = 0 53-0 78) Implications Less than half of caregivers in a global sample are willing to accept abbreviated vaccine testing during the COVID-19 pandemic As part of an effort to increase acceptance and uptake of the new vaccine, especially in order to protect children, public health strategies and individual providers should understand caregivers�?attitudes towards approval of the vaccine and consult them appropriately
AU  - Goldman, Ran D.
AU  - Marneni, Shashidhar R.
AU  - Seiler, Michelle
AU  - Brown, Julie C.
AU  - Klein, Eileen J.
AU  - Cotanda, Cristina Parra
AU  - Gelernter, Renana
AU  - Yan, Tyler D.
AU  - Hoeffe, Julia
AU  - Davis, Adrienne L.
AU  - Griffiths, Mark A.
AU  - Hall, Jeanine E.
AU  - Gualco, Gianluca
AU  - Mater, Ahmed
AU  - Manzano, Sergio
AU  - Thompson, Graham C.
AU  - Ahmed, Sara
AU  - Ali, Samina
AU  - Shimizu, Naoki
AU  - Ahmed, Sarah
AU  - Ali, Samina
AU  - Brown, Julie C.
AU  - Davis, Adrienne L.
AU  - Gaucher, Nathalie
AU  - Gianluca, Gualco
AU  - Goldman, Ran
AU  - Griffiths, Mark
AU  - Hall, Jeanine E.
AU  - Hansen, Matt
AU  - Katsuta, Tomohiro
AU  - Kelly, Christopher
AU  - Klein, Eileen J.
AU  - Kozer, Eran
AU  - Shashidhar, R. Marneni
AU  - Mater, Ahmed
AU  - Mistry, Rakesh
AU  - Parra, Cristina
AU  - Poonai, Naveen
AU  - Sheridan, David
AU  - Shimizu, Naoki
AU  - Yue, Esther L.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Caregivers�?willingness to accept expedited vaccine research during the COVID-19 pandemic �?a cross sectional survey
T2  - Clinical Therapeutics
TI  - Caregivers�?willingness to accept expedited vaccine research during the COVID-19 pandemic �?a cross sectional survey
UR  - https://doi.org/10.1016/j.clinthera.2020.09.012
ID  - 7793202
ER  - 

TY  - JOUR
AB  - Infection preventive practice of using disinfectants against SARS-CoV-2 has become the new normal due to the COVID-19 pandemic Although disinfectants may not be applied directly to the human body, it remains at high risk of exposure including close skin contact on disinfected surfaces or during handling This dermal contact, on a regular basis, can induce hazardous skin reactions like irritation, inflammation, and burning in severe conditions Disinfectants are germicide chemicals that can penetrate the skin and create skin reactions that are usually regarded as irritant and allergic contact dermatitis More importantly, disinfectants can react with skin components (proteins and lipids) to facilitate their skin penetration and disrupt the skin barrier function Whereas the antimicrobial actions of disinfectants are well understood, much less is known regarding their dermatologic reactions, including but not limited to irritation and hypersensitivity We reviewed the skin reactions created by those disinfectants against SARS-CoV-2 approved by the European Chemical Agency and the United States Environmental Protection Agency
AU  - Goh, Choon Fu
AU  - Ming, Long Chiau
AU  - Wong, Li Ching
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Dermatologic reactions to disinfectant use during the COVID-19 pandemic
T2  - Clinics in Dermatology
TI  - Dermatologic reactions to disinfectant use during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.clindermatol.2020.09.005
ID  - 7793203
ER  - 

TY  - JOUR
AB  - Several recent studies identified SARS-CoV-2 reactive T cells in people without exposure to the virus. However, pathophysiological implications of these findings remain unknown. Here, the potential impact of pre-existing T cell reactivity against SARC-CoV-2 in uninfected individuals on markedly different COVID-19 mortality levels in different countries has been investigated. The inverse correlation is documented between the prevalence of pre-existing SARS-CoV-2 reactive T cells in people without exposure to the virus and COVID-19 mortality rates in different countries. In countries with similar levels of pre-existing SARS-CoV-2 cross-reactive T cells in uninfected individuals, differences in COVID-19 mortality appear linked with the extend and consistency of implementations of social measures designed to limit the transmission of SARS-CoV-2 (lockdown; physical distancing; mask wearing). Collectively, these observations support the model that the level of pre-existing SARS-CoV-2 reactive T cells is one of the important determinants of the innate herd immunity against COVID-19. Together with the consistent social measures directed to limit the virus spread, high levels of pre-existing SARS-CoV-2 reactive T cells appear significant determinants diminishing the COVID-19 mortality. Observations reported in this contribution should have significant impact on definitions of the herd immunity threshold required to effectively stop the pandemic in different countries across the globe.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo applicable funding.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Not applicable.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data referred to in the manuscript and note are available.
AU  - Glinsky, Gennadi
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206151
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206151
ST  - Impact of pre-existing SARS-CoV-2 reactive T cells in uninfected individuals on COVID-19 mortality in different countries (preprint)
T2  - medRxiv
TI  - Impact of pre-existing SARS-CoV-2 reactive T cells in uninfected individuals on COVID-19 mortality in different countries (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206151.abstract
ID  - 7794751
ER  - 

TY  - JOUR
AB  - PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.
AD  - University of Birmingham, Birmingham, United Kingdom.
Department of Colorectal Surgery, Royal Marsden Hospital, London, United Kingdom.
AN  - 33021869
AU  - Glasbey, J. C.
AU  - Bhangu, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1200/jco.20.01933
DP  - NLM
ET  - 2020/10/07
J2  - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
LA  - eng
N1  - 1527-7755
Glasbey, James C
Orcid: 0000-0001-7688-5018
Bhangu, Aneel
Orcid: 0000-0001-5999-4618
COVIDSurg Collaborative
Journal Article
United States
J Clin Oncol. 2020 Oct 6:JCO2001933. doi: 10.1200/JCO.20.01933.
PY  - 2020
SN  - 0732-183x
SP  - Jco2001933
ST  - Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
T2  - Journal of clinical oncology : official journal of American Society of Clinical Oncology
TI  - Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study
ID  - 7790998
ER  - 

TY  - JOUR
AB  - Lodoicea maldivica (J. F. Gmel.) Pers. (Arecaceae), 'Coco de Mer', is a palm, growing as endemic in the Seychelles islands. Its fruit weighs up to 20 kg and is characterized by a fleshy and fibrous envelope surrounding the nutlike portion. The present work combines for the first time a morpho-anatomical and a phytochemical analysis of the fruit exocarp and mesocarp. The exocarp is composed by a layer of palisade cells. The mesocarp is characterized by vascular bundles and by sclereids. In the aerenchyma, the internal zone of the mesocarp, cells aggregates were positive to phenols, while idioblasts were positive to terpenes. The GC-MS essential oil profile revealed the dominance of acyclic sesquiterpenoids (53.95%), followed by bicyclic sesquiterpenoids (31.69%), monoterpenes (11.89%) and monocyclic sesquiterpenoids (2.44%). The terpens detected in higher amounts, β-caryophyllene and bicyclogermacrene, are known for activity against insect larves, but have been proposed as anti-viral candidates with against SARS-CoV-2. The third compound in amount, aromadendrene, is active against bacteria and, again, known to possess insecticidal properties. p { margin-bottom: 0.25cm; direction: ltr; line-height: 115%; text-align: left; orphans: 2; widows: 2 } p.western { font-family: "Myriad Pro", serif; font-size: 8pt; so-language: de-DE } p.cjk { font-size: 8pt; so-language: ja-JP } p.ctl { font-size: 12pt } a:link { color: #0563c1 }.
AD  - Universita degli Studi di Milano Facolta di Medicina e Chirurgia, Scienze Farmaceutiche, Via Mangiagalli 25, Milano, ITALY.
Universita degli Studi di Firenze, CISM, Viale Pieraccini 6, Firenze, ITALY.
Universita degli Studi di Firenze, Biology, Via Micheli 3, Firenze, ITALY.
Universita degli Studi di Milano, Scienze Farmaceutiche, Via Mangiagalli, Milano, ITALY.
Universita degli Studi di Firenze, Biology, Via Micheli 3, Florence, ITALY.
Universita degli Studi di Firenze, Biology, Via micheli 3, 50121, Firenze, ITALY.
AN  - 33025751
AU  - Giuliani, C.
AU  - Pieraccini, G.
AU  - Santilli, C.
AU  - Tani, C.
AU  - Bottoni, M.
AU  - Schiff, S.
AU  - Fico, G.
AU  - Papini, A.
AU  - Falsini, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/cbdv.202000707
DP  - NLM
ET  - 2020/10/08
J2  - Chemistry & biodiversity
KW  - Anatomy
Coco de Mer
Essential Oil
Gc-ms
terpenoids
LA  - eng
N1  - 1612-1880
Giuliani, Claudia
Pieraccini, Giuseppe
Santilli, Carolina
Tani, Corrado
Bottoni, Martina
Schiff, Silvia
Fico, Gelsomina
Papini, Alessio
Falsini, Sara
Journal Article
Switzerland
Chem Biodivers. 2020 Oct 6. doi: 10.1002/cbdv.202000707.
PY  - 2020
SN  - 1612-1872
ST  - Anatomical investigation and GC-MS analysis of "Coco de Mer", Lodoicea maldivica (J. F. Gmel.) Pers. (Arecaceae)
T2  - Chemistry & biodiversity
TI  - Anatomical investigation and GC-MS analysis of "Coco de Mer", Lodoicea maldivica (J. F. Gmel.) Pers. (Arecaceae)
ID  - 7790681
ER  - 

TY  - JOUR
AB  - We generated 274 SARS-CoV-2 genomes from samples collected during the early phase of the Kenyan pandemic. Phylogenetic analysis identified 8 global lineages and at least 76 independent SARS-CoV-2 introductions into Kenyan coast. The dominant B.1 lineage (European origin) accounted for 82.1% of the cases. Lineages A, B and B.4 were detected from screened individuals at the Kenya-Tanzania border or returning travellers but did not lead to established transmission. Though multiple lineages were introduced in coastal Kenya within three months following the initial confirmed case, none showed extensive local expansion other than cases characterised by lineage B.1, which accounted for 45 of the 76 introductions. We conclude that the international points of entry were important conduits of SARS-CoV-2 importations. We speculate that early public health responses prevented many introductions leading to established transmission, but nevertheless a few undetected introductions were sufficient to give rise to an established epidemic.Competing Interest StatementD.J.N. is a member of the National COVID-19 Modelling Technical Committee, for the Ministry of Health, Government of Kenya. K.K., R.A., J.K. are from the Ministry of Health, Government of Kenya. E.M., B.K., T.S., M.M., J.N., J.O., B.S. are from the respective county departments of health. All other authors declare no competing interests.Funding StatementThis work was supported by the National Institute for Health Research (NIHR) (project references 17/63/82 and 16/136/33 using UK aid from the UK Government to support global health research, The UK Department for International Development (DfID) and Wellcome Trust (grant# 102975; 220985)Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The samples were collected under the Kenya Ministry of Health (MoH) protocols as part of the national response to the COVID-19 pandemic. The whole genome sequencing study protocol was reviewed and approved by the Scientific and Ethics Review Committee (SERU) that sits at the Kenya Medical Research Institute (KEMRI) headquarters in Nairobi (SERU # 4035). All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesSARS-CoV-2 sequence data used in this analysis are publicly available from GSAID Source code that was used in the analysis of this work is available from GitHub ( https://github.com/george-githinji/SARS-CoV-2_KE) and data used to create the figures can also be found in the supplemental files.https://github.com/george-githinji/SARS-CoV-2_KE
AU  - Githinji, George
AU  - deLaurent, Zaydah R.
AU  - Mohamed, Khadija Said
AU  - Omuoyo, Donwilliams O.
AU  - Macharia, Peter M.
AU  - Morobe, John M.
AU  - Otieno, Edward
AU  - Kinyanjui, Samson M.
AU  - Agweyu, Ambrose
AU  - Maitha, Eric
AU  - Kitole, Ben
AU  - Suleiman, Thani
AU  - Mwakinangu, Mohamed
AU  - Nyambu, John
AU  - Otieno, John
AU  - Salim, Barke
AU  - Kasera, Kadondi
AU  - Kiiru, John
AU  - Aman, Rashid
AU  - Barasa, Edwine
AU  - Warimwe, George
AU  - Bejon, Philip
AU  - Tsofa, Benjamin
AU  - Ochola-Oyier, Lynette Isabella
AU  - Nokes, D. James
AU  - Agoti, Charles N.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206730
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206730
ST  - Tracking the introduction and spread of SARS-CoV-2 in coastal Kenya (preprint)
T2  - medRxiv
TI  - Tracking the introduction and spread of SARS-CoV-2 in coastal Kenya (preprint)
UR  - http://medrxiv.org/content/early/2020/10/07/2020.10.05.20206730.abstract
ID  - 7794711
ER  - 

TY  - JOUR
AB  - COVID-19 convalescent plasma (CCP) received approval for use under an Emergency Use Authorization by the FDA for treatment of seriously ill patients. Use of CCP units with a signal-to-cutoff ratio of �?2 using the Ortho VITROS SARS-CoV-2 IgG test (OVSARS2IgG) is authorized. Little is known about the relationship between this ratio and the neutralizing capacity of plasma/sera against genuine SARS-CoV-2 virus. We measured the neutralizing capacity of 981 samples from 196 CCP donors 7-119 days post initial donation (DPID). Neutralizing capacity was assessed for 50% (PRNT50) and 90% (PRNT90) reduction of infectious virus using the gold standard plaque reduction neutralization test (PRNT). Importantly, while 32.7%/79.5% (PRNT90/PRNT50) of donations met the FDA minimum titer of 1:80 initially, only 14.0%/48.8% (PRNT90/PRNT50) met this cut-off �?5 DPID. A subset of 91 donations were evaluated using the OVSARS2IgG and compared to PRNT titers for diagnostic accuracy. The correlation of OVSARS2IgG results to neutralizing capacity allowed extrapolation to CCP therapy efficacy results. CCP with OVSARS2IgG ratios in the therapeutically beneficial group had neutralizing titers of �?:640 (PRNT50) and/or �?:80 (PRNT90). This information provides a new basis for refining the recommended properties of CCP that is used to treat severe COVID-19.Competing Interest StatementThe authors have declared no competing interest.Funding StatementSupport was provided by CDC ELC CARES for COVID-19.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Testing at the Wadsworth Center was done under protocol 20-021 with approval from the NYSDOH Institutional Review Board.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesYes
AU  - Girardin, Roxie
AU  - Dupuis, Alan lI
AU  - Payne, Anne F.
AU  - Sullivan, Timothy J.
AU  - Strauss, Donna
AU  - Parker, Monica M.
AU  - McDonough, Kathleen
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206011
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206011
ST  - Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time (preprint)
T2  - medRxiv
TI  - Temporal Analysis of COVID-19 Convalescent Plasma Donations Reveals Significant Decrease in Neutralizing Capacity Over Time (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206011.abstract
ID  - 7794766
ER  - 

TY  - JOUR
AB  - BACKGROUND: It is crucial that nursing homes have adequate personal protective equipment (PPE) and staff in order to protect residents and staff from COVID-19. Some states have taken actions to mitigate shortages of PPE and staffing in nursing homes, including creating dedicated long-term care (LTC) teams and supporting staffing capacity. OBJECTIVE: To examine whether state actions and nursing home characteristics are associated with shortages of PPE and staffing. DESIGN AND SETTING: Facility-level data released July 31(st) , 2020 from the Nursing Home COVID-19 Public File was combined with data from other sources. Our sample was the 13,445 facilities with information about PPE and staffing shortages for each of the five weeks between the week ending June 21(st) , 2020 and the week ending July 19(th) , 2020. Associations between facility characteristics and shortages were examined using descriptive statistics and logistic regression models. MEASUREMENTS: Outcome variables were whether or not a facility lacked a one-week supply of PPE ("PPE shortage") and whether or not a facility had a staffing shortage during one or more weeks over the five-week study period. RESULTS: Over the five-week study period, 27.6% of facilities reported one or more weeks of PPE shortage, 30.2% of facilities reported at least one week of staffing shortage, and 46.5% of facilities lacked PPE and/or staff. Facilities located in states in the Northeastern PPE consortium or with LTC teams were modestly less likely to have had a PPE shortage and facilities located in states that implemented processes to match job seekers with LTC facilities were marginally significantly less likely to have had a staffing shortage. CONCLUSION: Given that nearly half of U.S. nursing homes recently faced a shortage of PPE and/or staff, and that state budget deficits may limit further state actions, ongoing federal assistance with PPE and staffing of nursing homes is needed.
AD  - Marxe School of Public and International Affairs, Baruch College - City University of New York.
AN  - 33022757
AU  - Gibson, D. M.
AU  - Greene, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/jgs.16883
DP  - NLM
ET  - 2020/10/07
J2  - Journal of the American Geriatrics Society
KW  - Covid-19
Nursing homes
personal protective equipment
staffing
LA  - eng
N1  - 1532-5415
Gibson, Diane M
Orcid: 0000-0002-3140-3510
Greene, Jessica
Journal Article
United States
J Am Geriatr Soc. 2020 Oct 6. doi: 10.1111/jgs.16883.
PY  - 2020
SN  - 0002-8614
ST  - State Actions and Shortages of Personal Protective Equipment and Staff in U.S. Nursing Homes
T2  - Journal of American Geriatrics Society
TI  - State Actions and Shortages of Personal Protective Equipment and Staff in U.S. Nursing Homes
ID  - 7790947
ER  - 

TY  - JOUR
AB  - Understanding changes in human mobility in the early stages of the COVID-19 pandemic is crucial for assessing the impacts of travel restrictions designed to reduce disease spread. Here, relying on data from mainland China, we investigate the spatio-temporal characteristics of human mobility between 1st January and 1st March 2020, and discuss their public health implications. An outbound travel surge from Wuhan before travel restrictions were implemented was also observed across China due to the Lunar New Year, indicating that holiday travel may have played a larger role in mobility changes compared to impending travel restrictions. Holiday travel also shifted healthcare pressure related to COVID-19 towards locations with lower healthcare capacity. Network analyses showed no sign of major changes in the transportation network after Lunar New Year. Changes observed were temporary and did not lead to structural reorganisation of the transportation network during the study period.
AD  - Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Hamish.Gibbs@lshtm.ac.uk.
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Hamish.Gibbs@lshtm.ac.uk.
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Yang.Liu@lshtm.ac.uk.
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK. Yang.Liu@lshtm.ac.uk.
Department of Infectious Disease Epidemiology, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
Centre for Mathematical Modelling of Infectious Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.
AN  - 33024096
AU  - Gibbs, H.
AU  - Liu, Y.
AU  - Pearson, C. A. B.
AU  - Jarvis, C. I.
AU  - Grundy, C.
AU  - Quilty, B. J.
AU  - Diamond, C.
AU  - Eggo, R. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41467-020-18783-0
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Nature communications
LA  - eng
N1  - 2041-1723
Gibbs, Hamish
Liu, Yang
Orcid: 0000-0002-9368-0425
Pearson, Carl A B
Orcid: 0000-0003-0701-7860
Jarvis, Christopher I
Grundy, Chris
Quilty, Billy J
Diamond, Charlie
LSHTM CMMID COVID-19 working group
Eggo, Rosalind M
Orcid: 0000-0002-0362-6717
INV-003174/Bill and Melinda Gates Foundation (Bill & Melinda Gates Foundation)/
221303/Z/20/Z/Department for International Development (Department for International Development, UK)/
221303/Z/20/Z/Wellcome Trust (Wellcome)/
Journal Article
England
Nat Commun. 2020 Oct 6;11(1):5012. doi: 10.1038/s41467-020-18783-0.
PY  - 2020
SN  - 2041-1723
SP  - 5012
ST  - Changing travel patterns in China during the early stages of the COVID-19 pandemic
T2  - Nature communications
TI  - Changing travel patterns in China during the early stages of the COVID-19 pandemic
VL  - 11
ID  - 7790840
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has unleashed a deluge of publications. For this cross-sectional study we compared the amount and reporting characteristics of COVID-19-related academic articles and preprints and the number of ongoing clinical trials and systematic reviews. To do this, we searched the PubMed database of citations and abstracts for published life science journals by using appropriate combinations of medical subject headings (MeSH terms), and the COVID-19 section of the MedRxiv and BioRxiv archives up to 20 May 2020 (21 weeks). In addition, we searched Clinicaltrial.gov, Chinese Clinical Trial Registry, EU Clinical Trials Register, and 15 other trial registers, as well as PROSPERO, the international prospective register of systematic reviews. The characteristics of each publication were extracted. Regression analyses and Z tests were used to detect publication trends and their relative proportions. A total of 3635 academic publications and 3805 preprints were retrieved. Only 8.6% (n = 329) of the preprints were already published in indexed journals. The number of academic and preprint publications increased significantly over time (p0.001). Case reports (6% academic vs 0.9% preprints; p0.001) and letters (17.4% academic vs 0.5% preprints; p0.001) accounted for a greater share of academic compared to preprint publications. Differently, randomized controlled trials (0.22% vs 0.63%; p0.001) and systematic reviews (0.08% vs 5%) made up a greater share of the preprints. The relative proportion of clinical studies registered at Clinicaltrials.gov, Chinese Clinical Trial Registry, and EU Clinical Trials Register was 57.9%, 49.5%, and 98.9%, respectively, most of which were still "recruiting". PROSPERO listed 962 systematic review protocols. Preprints were slightly more prevalent than academic articles but both were increasing in number. The void left by the lack of primary studies was filled by an outpour of immediate opinions (i.e., letters to the editor) published in PubMed-indexed journals. Summarizing, preprints have gained traction as a publishing response to the demand for prompt access to empirical, albeit not peer-reviewed, findings during the present pandemic.
AD  - Unit of Clinical Epidemiology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Global Health and Tropical Medicine (GHTM), WHO Collaborating Centre for Health Workforce Policy and Planning, Institute of Hygiene and Tropical Medicine-NOVA University of Lisbon, Lisbon, Portugal.
AN  - 33022014
AU  - Gianola, S.
AU  - Jesus, T. S.
AU  - Bargeri, S.
AU  - Castellini, G.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240123
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Gianola, Silvia
Jesus, Tiago S
Bargeri, Silvia
Castellini, Greta
Orcid: 0000-0002-3345-8187
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0240123. doi: 10.1371/journal.pone.0240123. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240123
ST  - Characteristics of academic publications, preprints, and registered clinical trials on the COVID-19 pandemic
T2  - PloS one
TI  - Characteristics of academic publications, preprints, and registered clinical trials on the COVID-19 pandemic
VL  - 15
ID  - 7790990
ER  - 

TY  - JOUR
AU  - Giacometti, C.
AU  - Maino, M.
AU  - Ambrosi, A.
AU  - Zanovello, S.
AU  - Beda, M.
AU  - Mion, M.
AU  - Mancuso, T.
AU  - Duodeci, S.
AU  - Cassaro, M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - 559 Poster - Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care during COVID-19 outbreak in North-Eastern Italy. When the going gets tough, the tough gets going!
T2  - European Journal of Cancer
TI  - 559 Poster - Multidisciplinary team meeting and EUSOMA quality indicators in breast cancer care during COVID-19 outbreak in North-Eastern Italy. When the going gets tough, the tough gets going!
UR  - https://doi.org/10.1016/S0959-8049(20)30861-3
ID  - 7793015
ER  - 

TY  - JOUR
AD  - Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Center for Research on Intracellular Bacteria, Institute of Microbiology, Centre Hospitalier Universitaire Vaudois, CH-1011 Lausanne, Switzerland.
Materno-fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Electronic address: david.baud@chuv.ch.
AN  - 33022363
AU  - Gengler, C.
AU  - Dubruc, E.
AU  - Favre, G.
AU  - Greub, G.
AU  - Leval, L.
AU  - Baud, D.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.cmi.2020.09.049
DP  - NLM
ET  - 2020/10/07
J2  - Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
LA  - eng
N1  - 1469-0691
Gengler, Carole
Dubruc, Estelle
Favre, Guillaume
Greub, Gilbert
Leval, Laurence de
Baud, David
Letter
England
Clin Microbiol Infect. 2020 Oct 3:S1198-743X(20)30603-0. doi: 10.1016/j.cmi.2020.09.049.
PY  - 2020
SN  - 1198-743x
ST  - SARS-CoV-2 ACE-Receptor detection in the placenta throughout pregnancy
T2  - Clinical microbiology and infection : official publication of European Society of Clinical Microbiology and Infectious Diseases
TI  - SARS-CoV-2 ACE-Receptor detection in the placenta throughout pregnancy
ID  - 7790964
ER  - 

TY  - JOUR
AB  - Background COVID 19 mortality risk is associated with demographic and behavioural factors; furthermore religious gatherings have been linked with the spread of COVID. We sought to understand the variation in the risk of COVID 19 related death across religious groups in the UK both before and after lockdown. Methods We conducted a retrospective cohort study of usual residents in England and Wales enumerated at the 2011 Census (n = 48,422,583), for risk of death involving COVID-19 using linked death certificates. Cox regression models were estimated to compare risks between religious groups. Time dependent religion coefficients were added to the model allowing hazard ratios (HRs) pre and post lockdown period to be estimated separately. Results Compared to Christians all religious groups had an elevated risk of death involving COVID-19; the largest age adjusted HRs were for Muslim and Jewish males at 2.5 (95% confidence interval 2.3-2.7) and 2.1 (1.9-2.5), respectively. The corresponding HRs for Muslim and Jewish females were 1.9 (1.7-2.1) and 1.5 (1.7-2.1). The difference in risk between groups contracted after lockdown. Those who affiliated with no religion had the lowest risk of COVID 19 related death before and after lockdown. Conclusion The majority of the variation in COVID 19 mortality risk was explained by controlling for socio demographic and geographic determinants; however, Jews remained at a higher risk of death compared to all other groups. Lockdown measures were associated with reduced differences in COVID 19 mortality rates between religious groups, further research is required to understand the causal mechanisms.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding receivedAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Following assessment using the NSDEC&#039;s tool, we engaged with the UK Statistics Authority Data Ethics team and it was decided that ethical approval was not required. This is standard practice for analysing national Census data.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData are presented in the supplementary material. Under the provisions of the Statistics and Registration Service Act 2007, the linked 2011 Census data used in this study are not permitted to be shared.
AU  - Gaughan, Charlotte
AU  - Ayoubkhani, Daniel
AU  - Nafilyan, Vahe
AU  - Goldblatt, Peter
AU  - White, Chris
AU  - Tingay, Karen
AU  - Bannister, Neil
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.01.20204495
DP  - medRxiv
PY  - 2020
SP  - 2020.10.01.20204495
ST  - Religious affiliation and the risk of COVID 19 related mortality; a retrospective analysis of variation in pre and post lockdown risk by religious group in England and Wales (preprint)
T2  - medRxiv
TI  - Religious affiliation and the risk of COVID 19 related mortality; a retrospective analysis of variation in pre and post lockdown risk by religious group in England and Wales (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.01.20204495.abstract
ID  - 7794778
ER  - 

TY  - JOUR
AB  - PURPOSE OF REVIEW: Cardiotoxicity by anticancer agents has emerged as a multifaceted issue and is expected to affect both mortality and morbidity. This review summarizes clinical challenges in the management of oncological patients requiring anticoagulants for atrial fibrillation (AF) also considering the current outbreak of the COVID-19 (coronavirus disease 2019) pandemic, since this infection can add challenges to the management of both conditions. Specifically, the aims are manyfold: (1) describe the evolving use of direct oral anticoagulants (DOACs) in AF patients with cancer; (2) critically appraise the risk of clinically important drug-drug interactions (DDIs) between DOACs and oral targeted anticancer agents; (3) address expected DDIs between DOACs and candidate anti-COVID drugs, with implications on management of the underlying thrombotic risk; and (4) characterize the proarrhythmic liability in cardio-oncology in the setting of COVID-19, focusing on QT prolongation. RECENT FINDINGS: AF in cardio-oncology poses diagnostic and management challenges, also due to the number of anticancer drugs recently associated with AF onset/worsening. Oral targeted drugs can potentially interact with DOACs, with increased bleeding risk mainly due to pharmacokinetic DDIs. Moreover, the vast majority of oral anticancer agents cause QT prolongation with direct and indirect mechanisms, potentially resulting in the occurrence of torsade de pointes, especially in susceptible patients with COVID-19 receiving additional drugs with QT liability. Oncologists and cardiologists must be aware of the increased bleeding risk and arrhythmic susceptibility of patients with AF and cancer due to DDIs. High-risk individuals with COVID-19 should be prioritized to target preventive strategies, including optimal antithrombotic management, medication review, and stringent monitoring.
AD  - Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Cardiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Division of Oncology, S. Orsola-Malpighi Hospital, Bologna, Italy.
Medical Oncology Unit, Department of Experimental, Diagnostic and Specialty Medicine, Policlinico S. Orsola-Malpighi, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Cardiology Unit, Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum - University of Bologna, Bologna, Italy. igor.diemberger@unibo.it.
AN  - 33025463
AU  - Gatti, M.
AU  - Raschi, E.
AU  - Poluzzi, E.
AU  - Martignani, C.
AU  - Salvagni, S.
AU  - Ardizzoni, A.
AU  - Diemberger, I.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11897-020-00485-9
DP  - NLM
ET  - 2020/10/08
J2  - Current heart failure reports
KW  - Anticancer agents
Atrial fibrillation
Covid-19
Direct oral anticoagulants
Drug-drug interactions
QT prolongation
LA  - eng
N1  - 1546-9549
Gatti, Milo
Raschi, Emanuel
Poluzzi, Elisabetta
Martignani, Cristian
Salvagni, Stefania
Ardizzoni, Andrea
Diemberger, Igor
Journal Article
Review
United States
Curr Heart Fail Rep. 2020 Oct 6. doi: 10.1007/s11897-020-00485-9.
PY  - 2020
SN  - 1546-9530
ST  - The Complex Management of Atrial Fibrillation and Cancer in the COVID-19 Era: Drug Interactions, Thromboembolic Risk, and Proarrhythmia
T2  - Current heart failure reports
TI  - The Complex Management of Atrial Fibrillation and Cancer in the COVID-19 Era: Drug Interactions, Thromboembolic Risk, and Proarrhythmia
ID  - 7790705
ER  - 

TY  - JOUR
AB  - Points of entry (PoE) have a crucial role in responding to a public health event of international concern (PHEIC) such as COVID-19 Border measures such as entry screening, quarantine and communication are implemented to stop or slow down the spread of COVID-19 Temperature screening at airports, denied access to ports for cruise ships with suspected cases on-board, long-lasting quarantine on board of a cruise ship or temporary suspending cross-border train traffic are just some examples of how PoE are affected by the current outbreak situation Using the network of the EU Joint Action Healthy Gateways group (JAHG) on preparedness and action at PoE, this workshop aims to highlight strategies and experiences across Europe with respect to awareness, prevention, detection and control of COVID-19 at PoE The workshop will give a short overview of the current situation in Europe and briefly elaborate on expected and unexpected roles of PoE during the COVID-19 outbreak Selected key aspects and case-based reports regarding COVID-19 management at PoE will be lined out and discussed: Experiences, challenges and needs of PoE in Europe Communication and information strategies are crucial in an outbreak situation The workshop will display case-based examples and emphasize on the challenges and efficacy of different strategies during the COVID-19 outbreak In addition, the need for and experiences of information exchange between POE will be stressed and illustrated An outbreak situation with a formerly unknown, novel virus such as Sars-CoV-2 requires specific education and training at POE Practice examples of educational measures (such as e g personal instructions, written material, webinars etc ) as well as challenges in rapid development of training material and in assessing specific training needs will be highlighted What can we learn so far from COVID-19 outbreak management at PoE in Europe? Some preliminary practice recommendations for PoE will be put to discussion Preliminary results of a survey on how POE dealt with COVID-19 and the specific training needs PoE encountered in this situation will also be presented at the workshop PoE in Europe, and all over the world, play an important role in the COVID-19 outbreak This session provides the opportunity to discuss experiences and challenges of COVID-19 outbreak management at PoE from European countries and thereby contributes to skill building and knowledge exchange among experts from the field to learn for future outbreaks Key messages COVID-19 is a major challenge for PoE across Europe Diverse and partly non-coherent measures for the outbreak management have been put in place at PoE leaving room for harmonization Communication and information as well as specific education and training on site are particularly challenging and put burden on PoE staff Adaptive communication and training strategies are needed
AU  - Gateways, Organised by E. U. Healthy
AU  - Chair persons: Varvara Mouchtouri - Greece, Jan Heidrich Germany
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - 4.A. Round table: Points of entry in light of the COVID-19 outbreak �?a European perspective
T2  - European Journal of Public Health
TI  - 4.A. Round table: Points of entry in light of the COVID-19 outbreak �?a European perspective
UR  - https://doi.org/10.1093/eurpub/ckaa165.135
ID  - 7792919
ER  - 

TY  - JOUR
AB  - A 53-year-old man presented with acute loss of vision, negative scotoma and dyschromatopsia in his left eye. He reported contact with people with severe respiratory syndrome - coronavirus-2 (SARS-CoV-2) 8 days prior symptoms. Funduscopic examination revealed several retinal hemorrhages. Spectral-domain optical coherence tomography showed lesions consistent with acute macular neuroretinopathy and paracentral acute middle maculopathy. Quickly after his presentation, SARSCov-2 was confirmed by chest computed tomography-scan and RT-PCR in this patient. Thrombotic complications associated with Covid-19 infection have high incidence and may involve the retina. We described a case of retinal involvement associated with Covid-19 infection. PRÉCIS: Funduscopic examination revealed retinal hemorrhages in a man with loss of vision. Optical coherence tomography showed an acute macular neuroretinopathy and paracentral acute middle maculopathy. Coronavirus disease was confirmed by chest computed tomography-scan and RT-PCR.
AD  - Ophthalmology Department, Aix-Marseille University, Hopital Nord , Marseille, France.
Institut de Neurosciences de la Timone, Aix-Marseille University , Marseille, France.
Internal Medicine Department, Aix-Marseille University, Hopital Timone Rue Saint Pierre , Marseille, France.
AN  - 33021856
AU  - Gascon, P.
AU  - Briantais, A.
AU  - Bertrand, E.
AU  - Ramtohul, P.
AU  - Comet, A.
AU  - Beylerian, M.
AU  - Sauvan, L.
AU  - Swiader, L.
AU  - Durand, J. M.
AU  - Denis, D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/09273948.2020.1825751
DP  - NLM
ET  - 2020/10/07
J2  - Ocular immunology and inflammation
KW  - Covid-19
Retinal hemorrhages
acute macular neuroretinopathy
coronavirus disease
optical coherence tomography
paracentral acute middle maculopathy
roth spots
LA  - eng
N1  - 1744-5078
Gascon, Pierre
Orcid: 0000-0002-2012-8808
Briantais, Antoine
Bertrand, Emmanuelle
Ramtohul, Prithvi
Comet, Alban
Beylerian, Marie
Sauvan, Lauren
Swiader, Laure
Durand, Jean Marc
Denis, Dani؈le
Journal Article
England
Ocul Immunol Inflamm. 2020 Oct 6:1-5. doi: 10.1080/09273948.2020.1825751.
PY  - 2020
SN  - 0927-3948
SP  - 1-5
ST  - Covid-19-Associated Retinopathy: A Case Report
T2  - Ocular immunology and inflammation
TI  - Covid-19-Associated Retinopathy: A Case Report
ID  - 7791000
ER  - 

TY  - JOUR
AB  - Artificial intelligence applied to the educational field has a vast potential, especially after the effects worldwide of the COVID-19 pandemic Online or blended educational modes are needed to respond to the health situation we are living in The tutorial effort is higher than in the traditional face-to-face approach Thus, educational systems are claiming smarter learning technologies that do not pretend to substitute the faculty but make their teaching activities easy This Special Issue is oriented to present a collection of papers of original advances in educational applications and services propelled by artificial intelligence, big data, machine learning, and deep learning
AU  - Garc�Ta-Peñalvo, Francisco José Casado-Lumbreras Cristina
AU  - Colomo-Palacios, Ricardo
AU  - Yadav, Aman
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Smart Learning
T2  - Applied Sciences
TI  - Smart Learning
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813208
ID  - 7793360
ER  - 

TY  - JOUR
AB  - BACKGROUND: There are no published cases of tonic-clonic seizures and posterior bilateral blindness during pregnancy and Severe Acute Respiratory Syndrome (SARS) Coronavirus (COV) 2 (SARS-COV-2) infection. We do not just face new and unknown manifestations, but also how different patient groups are affected by SARS-COV-2 infection, such as pregnant women. Coronavirus Disease 2019 (COVID-19), preeclampsia, eclampsia and posterior reversible leukoencephalopathy share endothelium damage and similar pathophysiology. CASE PRESENTATION: A 35-year-old pregnant woman was admitted for tonic-clonic seizures and SARS-COV-2 infection. She had a normal pregnancy control and no other symptoms before tonic-clonic seizures development. After a Caesarean section (C-section) she developed high blood pressure, and we initiated antihypertensive treatment with labetalol, amlodipine and captopril. Few hours later she developed symptoms of cortical blindness that resolved in 72 h with normal brain computed tomography (CT) angiography. CONCLUSION: The authors conclude that SARS COV-2 infection could promote brain endothelial damage and facilitate neurological complications during pregnancy.
AD  - Department of Anaesthesiology and Critical Care, University Complex Hospital of Leon, 24071, City Leon, Spain.
Department of Anaesthesiology and Critical Care, University Complex Hospital of Leon, 24071, City Leon, Spain. s.marcos89@gmail.com.
Department of Obstetrics and Gynaecology, University Complex Hospital of Leon, 24071, City Leon, Spain.
Department of Neurology, University Complex Hospital of Leon, 24071, City Leon, Spain.
AN  - 33023500
AU  - Garcia Rodriguez, A.
AU  - Marcos Contreras, S.
AU  - Fernandez Manovel, S. M.
AU  - Marcos Vidal, J. M.
AU  - Diez Buron, F.
AU  - Fernandez Fernandez, C.
AU  - Riveira Gonzalez, M. D. C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s12884-020-03275-2
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMC pregnancy and childbirth
KW  - Covid-19
Case-report
Neurological manifestations
Preeclampsia
Pregnancy
LA  - eng
N1  - 1471-2393
Garcia Rodriguez, Alejandro
Marcos Contreras, Sergio
Orcid: 0000-0001-5788-7536
Fernandez Manovel, Santiago Manuel
Marcos Vidal, Jose Miguel
Diez Buron, Fernando
Fernandez Fernandez, Camino
Riveira Gonzalez, Maria Del Carmen
Journal Article
England
BMC Pregnancy Childbirth. 2020 Oct 6;20(1):587. doi: 10.1186/s12884-020-03275-2.
PY  - 2020
SN  - 1471-2393
SP  - 587
ST  - SARS-COV-2 infection during pregnancy, a risk factor for eclampsia or neurological manifestations of COVID-19? Case report
T2  - BMC pregnancy and childbirth
TI  - SARS-COV-2 infection during pregnancy, a risk factor for eclampsia or neurological manifestations of COVID-19? Case report
VL  - 20
ID  - 7790907
ER  - 

TY  - JOUR
AB  - Soaring cases of coronavirus disease (COVID-19) are pummeling the global health system. Overwhelmed health facilities have endeavored to mitigate the pandemic, but mortality of COVID-19 continues to increase. Here, we present a mortality risk prediction model for COVID-19 (MRPMC) that uses patients' clinical data on admission to stratify patients by mortality risk, which enables prediction of physiological deterioration and death up to 20 days in advance. This ensemble model is built using four machine learning methods including Logistic Regression, Support Vector Machine, Gradient Boosted Decision Tree, and Neural Network. We validate MRPMC in an internal validation cohort and two external validation cohorts, where it achieves an AUC of 0.9621 (95% CI: 0.9464-0.9778), 0.9760 (0.9613-0.9906), and 0.9246 (0.8763-0.9729), respectively. This model enables expeditious and accurate mortality risk stratification of patients with COVID-19, and potentially facilitates more responsive health systems that are conducive to high risk COVID-19 patients.
AD  - National Medical Center for Major Public Health Events, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
GNSS Research Center, Wuhan University, Wuhan, 430079, China.
City University of Hong Kong Shenzhen Research Institute, Shenzhen, 518000, China.
Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China.
Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. yeyuanbei@hotmail.com.
National Medical Center for Major Public Health Events, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. qingleigao@hotmail.com.
Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430000, China. qingleigao@hotmail.com.
AN  - 33024092
AU  - Gao, Y.
AU  - Cai, G. Y.
AU  - Fang, W.
AU  - Li, H. Y.
AU  - Wang, S. Y.
AU  - Chen, L.
AU  - Yu, Y.
AU  - Liu, D.
AU  - Xu, S.
AU  - Cui, P. F.
AU  - Zeng, S. Q.
AU  - Feng, X. X.
AU  - Yu, R. D.
AU  - Wang, Y.
AU  - Yuan, Y.
AU  - Jiao, X. F.
AU  - Chi, J. H.
AU  - Liu, J. H.
AU  - Li, R. Y.
AU  - Zheng, X.
AU  - Song, C. Y.
AU  - Jin, N.
AU  - Gong, W. J.
AU  - Liu, X. Y.
AU  - Huang, L.
AU  - Tian, X.
AU  - Li, L.
AU  - Xing, H.
AU  - Ma, D.
AU  - Li, C. R.
AU  - Ye, F.
AU  - Gao, Q. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41467-020-18684-2
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Nature communications
LA  - eng
N1  - 2041-1723
Gao, Yue
Cai, Guang-Yao
Fang, Wei
Li, Hua-Yi
Orcid: 0000-0002-1161-4943
Wang, Si-Yuan
Chen, Lingxi
Yu, Yang
Liu, Dan
Xu, Sen
Cui, Peng-Fei
Orcid: 0000-0003-2915-9157
Zeng, Shao-Qing
Feng, Xin-Xia
Yu, Rui-Di
Wang, Ya
Yuan, Yuan
Jiao, Xiao-Fei
Chi, Jian-Hua
Liu, Jia-Hao
Li, Ru-Yuan
Zheng, Xu
Song, Chun-Yan
Jin, Ning
Gong, Wen-Jian
Liu, Xing-Yu
Huang, Lei
Tian, Xun
Li, Lin
Xing, Hui
Ma, Ding
Li, Chun-Rui
Ye, Fei
Orcid: 0000-0002-0546-0239
Gao, Qing-Lei
Orcid: 0000-0002-9448-3423
81974405/National Natural Science Foundation of China (National Science Foundation of China)/
81873452/National Natural Science Foundation of China (National Science Foundation of China)/
81772787/National Natural Science Foundation of China (National Science Foundation of China)/
Journal Article
England
Nat Commun. 2020 Oct 6;11(1):5033. doi: 10.1038/s41467-020-18684-2.
PY  - 2020
SN  - 2041-1723
SP  - 5033
ST  - Machine learning based early warning system enables accurate mortality risk prediction for COVID-19
T2  - Nature communications
TI  - Machine learning based early warning system enables accurate mortality risk prediction for COVID-19
VL  - 11
ID  - 7790843
ER  - 

TY  - JOUR
AU  - Galvão, Jane
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19: the deadly threat of misinformation
T2  - Lancet Infectious Diseases
TI  - COVID-19: the deadly threat of misinformation
UR  - https://doi.org/10.1016/S1473-3099(20)30721-0
ID  - 7793013
ER  - 

TY  - JOUR
AB  - BACKGROUND: Proctology is one of the surgical specialties that suffered the most during COVID-19 pandemic. Using a cross-sectional non-incentivized worldwide web-survey we aimed to snapshot the current status of proctological practice in 6 world regions. METHODS: Surgeons affiliated to renowned scientific societies with an interest in coloproctology were invited to join the survey. Members of the ProctoLock Working Group enhanced recruitment by direct invitation. Predictive power of respondents' and hospitals' demographics on the change of status of surgical and outpatient activities was calculated. RESULTS: Respondents (N=1,050) were mostly men (79%), with a mean age of 46.9 years, at consultant level (79%), practicing in academic hospitals (53%), offering a dedicated proctology service (68%). A total of 119 (11%) tested COVID-19 positive. The majority (54%) came from Europe. Participants from Asia reported a higher proportion of unaltered practice (17%), while those from Europe had the highest proportion of fully stopped practice (20%). The likelihood of ongoing surgical practice was higher in males (OR 1.54, 95%CI 1.13;2.09; P=0.006), in those reporting readily availability of personal protective equipment (PPE) (OR 1.40, 1.08;1.42; P=0.012) and in centers that were partially or not at all involved in COVID-19 care (OR 2.95, 2.14;4.09; P0.001). This chance decreased by 2% per year of respondents' age (P=0.001). CONCLUSION: Several factors including different screening policies and resource capacity impacted the current status of proctological practice. This may inform health authorities to formulate effective preventive strategies to limit curtailment of care of these patients during the pandemic.
AD  - Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro, Italy.
Proctology and Pelvic Floor Clinical Centre, Cisanello University Hospital, Pisa, Italy.
Proctology Unit, Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, Roma, Italy.
The George Institute for Global Health, Faculty of Medicine, University of New South Wales, NSW, Australia.
SOSD Proctologia USL Toscana Centro, Prato, Italy.
IV Surgery Unit, Treviso Regional Hospital, University of Padua, Padua, Italy.
AN  - 33025724
AU  - Gallo, G.
AU  - Sturiale, A.
AU  - De Simone, V.
AU  - Di Tanna, G. L.
AU  - Giani, I.
AU  - Grossi, U.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/codi.15394
DP  - NLM
ET  - 2020/10/08
J2  - Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland
LA  - eng
N1  - 1463-1318
Gallo, Gaetano
Orcid: 0000-0003-1066-4671
Sturiale, Alessandro
Orcid: 0000-0002-0845-0933
De Simone, Veronica
Di Tanna, Gian Luca
Giani, Iacopo
Grossi, Ugo
ProctoLock 2020 Working Group
Journal Article
England
Colorectal Dis. 2020 Oct 6. doi: 10.1111/codi.15394.
PY  - 2020
SN  - 1462-8910
ST  - A Worldwide Survey On Proctological Practice During Covid-19 Lockdown (Proctolock 2020): A Cross-Sectional Analysis
T2  - Colorectal disease : official journal of Association of Coloproctology of Great Britain and Ireland
TI  - A Worldwide Survey On Proctological Practice During Covid-19 Lockdown (Proctolock 2020): A Cross-Sectional Analysis
ID  - 7790683
ER  - 

TY  - JOUR
AB  - BACKGROUND: COVID-19 infection is a new disease that infects a large number of people, killing a ratio of whom every day in the world. Healthcare staff, especially nurses, experience a great deal of psychological distress during care of COVID-19 patients. Detecting factors that disturb nurses' mental health during care of these patients can help to reduce their psychological distress. Therefore, this study aimed to explore nurses' experiences of psychological distress during care of patients with COVID-19. METHODS: The present qualitative research was performed using the conventional content analysis method in Iran from March to May 2020. Participants in this study included the nurses caring for patients with COVID-19, and they were selected based on the purposeful sampling method. The data was collected through 20 phone call interviews and analyzed based on the method proposed by Lundman and Graneheim. RESULTS: Qualitative data analysis revealed 11 categories including death anxiety, anxiety due to the nature of the disease, anxiety caused by corpse burial, fear of infecting the family, distress about time wasting, emotional distress of delivering bad news, fear of being contaminated, the emergence of obsessive thoughts, the bad feeling of wearing personal protective equipment, conflict between fear and conscience, and the public ignorance of preventive measures. CONCLUSION: The data showed that the nurses experienced a variety of psychological distress during care of patients with COVID-19. Through proper planning by authorities, it is possible to manage the risk factors of mental health distress in nurses and improve their mental health status.
AD  - Social Determinants of Health Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
School of Medicine and Allied Medical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.
School of Nursing and Midwifery, Lorestan University of Medical Sciences, Khorramabad, Iran.
Social Determinates of health center, Lorestan University of Medical Sciences, Kilomer 4 Khorramabad-Broujerd road Kamalvand, Khorramabad, 6813856967, Iran. H-hidari@razi.tums.ac.ir.
Department of Home-based palliative care, ALA Cancer Prevention and Control Center (MACSA), Tehran, Iran. H-hidari@razi.tums.ac.ir.
AN  - 33023535
AU  - Galehdar, N.
AU  - Kamran, A.
AU  - Toulabi, T.
AU  - Heydari, H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s12888-020-02898-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMC psychiatry
KW  - Covid-19
Mental distresses
Nurses
Qualitative study
LA  - eng
N1  - 1471-244x
Galehdar, Nasrin
Kamran, Aziz
Toulabi, Tahereh
Heydari, Heshmatolah
Orcid: 0000-0003-4815-5549
1371/Lorestan University of Medical Sciences/
Journal Article
England
BMC Psychiatry. 2020 Oct 6;20(1):489. doi: 10.1186/s12888-020-02898-1.
PY  - 2020
SN  - 1471-244x
SP  - 489
ST  - Exploring nurses' experiences of psychological distress during care of patients with COVID-19: a qualitative study
T2  - BMC psychiatry
TI  - Exploring nurses' experiences of psychological distress during care of patients with COVID-19: a qualitative study
VL  - 20
ID  - 7790905
ER  - 

TY  - JOUR
AB  - The destructive and ubiquitous nature of the COVID-19 pandemic presents a unique and important backdrop upon which to consider the practicality of an equitable approach to contemporary public administration To minimize or ignore the specialized needs of marginalized populations in the time of COVID-19 is to prolong the spread of the disease, social restrictions, and the ultimate recovery of the American economy, as those disproportionally impacted are often public-facing essential workers who cannot stay home and effectively social distance This commentary discusses the advancement of social equity as an essential component of policy planning in the current pandemic and offers practical administrative strategies for achievement, including heeding the data, dialoguing with community, partners, and taking courageous action
AU  - Gadson, Danielle N.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Advancing Equity in Public Administration: Prioritizing Equality of Outcomes in the COVID-19 Crisis
T2  - Risk, Hazards & Crisis in Public Policy
TI  - Advancing Equity in Public Administration: Prioritizing Equality of Outcomes in the COVID-19 Crisis
UR  - https://doi.org/10.1002/rhc3.12206
ID  - 7793306
ER  - 

TY  - JOUR
AU  - Fujiwara, Yu
AU  - Sato, Yasuyoshi
AU  - Wang, Xiaofei
AU  - Oikado, Katsunori
AU  - Sato, Yoshinao
AU  - Fukuda, Naoki
AU  - Enokida, Taisuke
AU  - Takeda, Koichi
AU  - Ohkushi, Daisuke
AU  - Hayama, Brian
AU  - Egi, Yoko
AU  - Tokai, Yoshitaka
AU  - Yamada, Yumi
AU  - Nakajima, Yuki
AU  - Kubota, Motoko
AU  - Haruki, Satomi
AU  - Shimizu, Takako
AU  - Uchida, Yasuko
AU  - Utsugi, Kuniko
AU  - Ito, Yoshinori
AU  - Ohno, Shinji
AU  - Takahashi, Shunji
AU  - Tsuchida, Tomohiro
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Screening for COVID-19 in Symptomatic Cancer Patients in a Cancer Hospital
T2  - Cancer Cell
TI  - Screening for COVID-19 in Symptomatic Cancer Patients in a Cancer Hospital
UR  - https://doi.org/10.1016/j.ccell.2020.09.017
ID  - 7793217
ER  - 

TY  - JOUR
AU  - Fujita, Jiro
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - SARS-CoV-2 as a causative agent of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disorders
T2  - Respiratory Investigation
TI  - SARS-CoV-2 as a causative agent of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disorders
UR  - https://doi.org/10.1016/j.resinv.2020.09.002
ID  - 7793062
ER  - 

TY  - JOUR
AD  - Bristol Heart Institute, Bristol, UK.
AN  - 33021144
AU  - Fudulu, D. P.
AU  - Angelini, G. D.
AU  - Vohra, H. A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0267659120961936
DP  - NLM
ET  - 2020/10/07
J2  - Perfusion
LA  - eng
N1  - 1477-111x
Fudulu, Daniel Paul
Orcid: 0000-0001-6759-7719
Angelini, Gianni D
Orcid: 0000-0002-1753-3730
Vohra, Hunaid A
Journal Article
England
Perfusion. 2020 Oct 6:267659120961936. doi: 10.1177/0267659120961936.
PY  - 2020
SN  - 0267-6591
SP  - 267659120961936
ST  - Minimally invasive cardiac valve surgery during the COVID-19 pandemic: to do or not to do, that is the question
T2  - Perfusion
TI  - Minimally invasive cardiac valve surgery during the COVID-19 pandemic: to do or not to do, that is the question
ID  - 7791048
ER  - 

TY  - JOUR
AB  - As increasing amounts of data accumulate on the effects of the novel coronavirus Sars-CoV-2 and the risk factors that lead to poor outcomes, it is possible to produce personalised estimates of the risks faced by groups of people with different characteristics. The challenge of how to communicate these then becomes apparent. Based on empirical work (total n=5,520, UK) supported by in-person interviews with public and physicians, we make recommendations on the presentation of such information. These include: using predominantly percentages when communicating the absolute risk, but also providing (for balance) a format which conveys a higher perception of risk (expected frequency out of 10,000); using a visual linear scale cut at an appropriate point to illustrate the maximum risk, explained through an illustrative &#039;persona&#039; who might face that highest level of risk; and providing context to the absolute risk through presenting a range of other &#039;personas&#039; illustrating people who would face risks of a wide range of different levels. These &#039;personas&#039; should have their major risk factors (age, existing health conditions) described. By contrast, giving people absolute likelihoods of other risks they face in an attempt to add context was considered less helpful.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was funded by the Winton Centre for Risk &amp;amp; Evidence Communication at the University of Cambridge, which is financed by a donation from the David &amp;amp; Claudia Harding Foundation.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was approved by the Psychological Research Ethics Committee at the University of Cambridge (PRE.2020.070).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe questionnaires and data for the surveys is available at: https://osf.io/auf8h/https://osf.io/auf8h/
AU  - Freeman, Alexandra L. J.
AU  - Kerr, John
AU  - Recchia, Gabriel
AU  - Schneider, Claudia
AU  - Lawrence, Alice C. E.
AU  - Finikarides, Leila
AU  - Luoni, Giulia
AU  - Dryhurst, Sarah
AU  - Spiegelhalter, David J.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206961
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206961
ST  - Communicating personalised risks from COVID-19: guidelines from an empirical study (preprint)
T2  - medRxiv
TI  - Communicating personalised risks from COVID-19: guidelines from an empirical study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206961.abstract
ID  - 7794753
ER  - 

TY  - JOUR
AU  - Frank, Stephan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Catch me if you can: SARS-CoV-2 detection in brains of deceased patients with COVID-19
T2  - Lancet Neurology
TI  - Catch me if you can: SARS-CoV-2 detection in brains of deceased patients with COVID-19
UR  - https://doi.org/10.1016/S1474-4422(20)30371-9
ID  - 7793010
ER  - 

TY  - JOUR
AB  - Although partisan politics tend be set aside during crisis, the timing of gubernatorial actions in response to COVID-19 is telling about how partisanship is shaping the way elected officials are reacting to this pandemic Using an event history analysis, the authors find that Democratic governors responded to the White House?s attempts to downplay the severity of the pandemic by declaring emergencies in order to draw citizen attention to and to prepare for a public health crisis On the other hand, Republican governors resisted doing so until Trump declared a national emergency on March 13;however, Republican reactions were conditional on the president?s job approval in their states While the COVID-19 pandemic has pushed governments into uncharted territory, state governors appear to be following patterns of vertical partisan competition that mirror those of more conventional policy areas in recent years
AU  - Fowler, Luke
AU  - Kettler, Jaclyn J.
AU  - Witt, Stephanie L.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Pandemics and Partisanship: Following Old Paths into Uncharted Territory
T2  - American Politics Research
TI  - Pandemics and Partisanship: Following Old Paths into Uncharted Territory
UR  - https://doi.org/10.1177/1532673X20961024
ID  - 7792842
ER  - 

TY  - JOUR
AB  - Covid-19 epidemic that swept the world in March 2020 paralyzed societies and put healthcare professionals at the forefront, both in cities and in hospitals. Perinatal care providers have had to adapt to meet the needs of women and children effectively, in complete safety. Caregivers have faced many challenges, but they have also invented new ways of working and developed better ways of collaborating. From this crisis, lessons must be learned to build for the future.
AN  - PMC7536515
AU  - Foulhy, Catherine
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.sagf.2020.07.008
DP  - NLM
KW  - confinement
Covid-19
épidémie
organisation
périnatalité
sécurité
epidemic
lockdown
organization
perinatal
safety
LA  - fre
N1  - PMC7536515[pmcid]
S1637-4088(20)30133-4[PII]
PY  - 2020
SN  - 1637-4088
ST  - Retrospective and perspectives
T2  - Sages-Femmes
TI  - Retrospective and perspectives
TT  - Rétrospective et perspectives
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536515/
ID  - 7790677
ER  - 

TY  - JOUR
AB  - When the COVID-19 pandemic forced university campuses and healthcare agencies to temporarily suspend both undergraduate and graduate direct care educational experiences, nursing programs had to formulate alternative plans to facilitate clinical learning Texas Woman&#039;s University used this opportunity to assemble a faculty group tasked with creating a set of college-wide guidelines for virtual simulation use as a substitution for traditional face-to-face clinical The process included completing a needs assessment of both undergraduate and graduate level programs across three campuses and identifying regulatory requirements and limitations for clinical experiences The task force utilized the information gathered to develop evidence-based recommendations for simulation hour equivalence ratios and compiled a list of virtual activities and products faculty could use to complete clinical experiences Undergraduate and graduate student surveys were conducted to determine the effectiveness of the transition to virtual clinical experiences Overall, the majority of survey results were positive regarding virtual simulation experiences providing students with valuable opportunities to enhance their learning Negative comments regarding the impact of COVID-19 on a personal level included issues involving internet access and web conferencing logistics, lack of motivation to study, family difficulties, and faculty inexperience teaching in an online environment Undergraduate pre-licensure students were provided with opportunities to successfully complete all remaining required clinical hours virtually, while graduate students were allowed to complete non-direct care hours as applicable using virtual clinical experiences
AU  - Fogg, Niki
AU  - Wilson, Cecilia
AU  - Trinka, Michele
AU  - Campbell, Rachelle
AU  - Thomson, Anne
AU  - Merritt, Linda
AU  - Tietze, Mari
AU  - Prior, Merry
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Transitioning from direct care to virtual clinical experiences during the COVID-19 pandemic
T2  - Journal of Professional Nursing
TI  - Transitioning from direct care to virtual clinical experiences during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.profnurs.2020.09.012
ID  - 7793076
ER  - 

TY  - JOUR
AB  - Regression to the mean is nice and reliable Regression to the tail is reliably scary We live in the age of regression to the tail It is only a matter of time until a pandemic worse than covid-19 will hit us, and climate more extreme than any we have seen What are the basic principles that generate such extreme risk, and for navigating it, for government, business, and the public?
AU  - Flyvbjerg, Bent
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The law of regression to the tail: How to survive Covid-19, the climate crisis, and other disasters
T2  - Environmental Science & Policy
TI  - The law of regression to the tail: How to survive Covid-19, the climate crisis, and other disasters
UR  - https://doi.org/10.1016/j.envsci.2020.08.013
ID  - 7793180
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a pandemic with growing global mortality. There is an urgent need to understand the molecular pathways required for host infection and anti-viral immunity. Using comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS), we identified 309 host proteins that bind the SARS-CoV-2 RNA during active infection. Integration of this data with viral ChIRP-MS data from three other positive-sense RNA viruses defined pan-viral and SARS-CoV-2-specific host interactions. Functional interrogation of these factors with a genome-wide CRISPR screen revealed that the vast majority of viral RNA-binding proteins protect the host from virus-induced cell death, and we identified known and novel anti-viral proteins that regulate SARS-CoV-2 pathogenicity. Finally, our RNA-centric approach demonstrated a physical connection between SARS-CoV-2 RNA and host mitochondria, which we validated with functional and electron microscopy data, providing new insights into a more general virus-specific protein logic for mitochondrial interactions. Altogether, these data provide a comprehensive catalogue of SARS-CoV-2 RNA-host protein interactions, which may inform future studies to understand the mechanisms of viral pathogenesis, as well as nominate host pathways that could be targeted for therapeutic benefit.Competing Interest StatementK.R.P., H.Y.C., and A.T.S. are co-founders of Cartography Biosciences. A.T.S. is a co-founder of Immunai and receives research funding from Arsenal Biosciences, Sonoma Biotherapeutics, and Allogene Therapeutics. H.Y.C. is a co-founder of Accent Therapeutics, Boundless Bio, and an advisor for 10x Genomics, Arsenal Biosciences, and Spring Discovery. Yale University (C.B.W.) has a patent pending related to this work entitled: Compounds and Compositions for Treating, Ameliorating, and/or Preventing SARS-CoV-2 Infection and/or Complications Thereof. Yale University has committed to rapidly executable non-exclusive royalty-free licenses to intellectual property rights for the purpose of making and distributing products to prevent, diagnose and treat COVID-19 infection during the pandemic and for a short period thereafter.
AU  - Flynn, Ryan A.
AU  - Belk, Julia A.
AU  - Qi, Yanyan
AU  - Yasumoto, Yuki
AU  - Schmitz, Cameron O.
AU  - Mumbach, Maxwell R.
AU  - Limaye, Aditi
AU  - Wei, Jin
AU  - Alfajaro, Mia Madel
AU  - Parker, Kevin R.
AU  - Chang, Howard Y.
AU  - Horvath, Tamas L.
AU  - Carette, Jan E.
AU  - Bertozzi, Carolyn
AU  - Wilen, Craig B.
AU  - Satpathy, Ansuman T.
C1  - 10/7/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.06.327445
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.06.327445
ST  - Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection (preprint)
T2  - bioRxiv
TI  - Systematic discovery and functional interrogation of SARS-CoV-2 viral RNA-host protein interactions during infection (preprint)
UR  - http://biorxiv.org/content/early/2020/10/06/2020.10.06.327445.abstract
ID  - 7794723
ER  - 

TY  - JOUR
AU  - Fitzpatrick, Kevin M.
AU  - Harris, Casey
AU  - Drawve, Grant
AU  - Willis, Don E.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Assessing Food Insecurity among US Adults during the COVID-19 Pandemic
T2  - Journal of Hunger & Environmental Nutrition
TI  - Assessing Food Insecurity among US Adults during the COVID-19 Pandemic
UR  - https://doi.org/10.1080/19320248.2020.1830221
ID  - 7792944
ER  - 

TY  - JOUR
AU  - Fisman, David N.
AU  - Greer, Amy L.
AU  - Hillmer, Michael
AU  - Tuite, Ashleigh R.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Derivation and Validation of Clinical Prediction Rules for COVID-19 Mortality in Ontario, Canada
T2  - Open Forum Infectious Diseases
TI  - Derivation and Validation of Clinical Prediction Rules for COVID-19 Mortality in Ontario, Canada
UR  - https://doi.org/10.1093/ofid/ofaa463
ID  - 7792896
ER  - 

TY  - JOUR
AB  - Résumé Lors de la pandémie due au virus SARS-CoV2 les troubles du rythme n’ont pas été au premier plan Cependant le virus semble atteindre de nombreux organes et le tropisme cardiaque est maintenant bien connu Les connaissances dans ce domaine sont encore loin d’être exhaustives mais plusieurs séries publiées concernant les patients atteints de la COVID-19 retrouvent une proportion significative de troubles du rythme, dont certains pouvant potentiellement mener à une issue fatale Ces troubles du rythme sont principalement supra-ventriculaires à type de fibrillation atriale (FA) ou flutter mais également ventriculaire avec des tachycardies ventriculaires (TV) fibrillation ventriculaire (FV) et plus rarement torsades de pointe (TdP) Les causes en sont multiples du fait de l’atteinte multi-organe du virus et des interactions médicamenteuses potentielles Par ailleurs la question de la surveillance de troubles du rythme pouvant émerger à moyen et long terme apr؈s une infection reste à explorer In the pandemic caused by the SARS-CoV2 virus, arrhythmias were not in the foreground However, the virus seems to affect many organs and the cardiac tropism is now well known Knowledge in this area is still far from exhaustive, but several series published concerning patients with COVID-19 find a significant proportion of arrhythmias, some of which can potentially lead to a fatal outcome These rhythm disorders are mainly supra-ventricular such as atrial fibrillation (AF) or flutter but also ventricular disorders like ventricular tachycardias (VT) ventricular fibrillation (VF) and more rarely torsades de pointe (TdP) The causes are multiple, due to the multi-organ damage caused by the virus and potential drug interactions In addition, the question of monitoring rhythm disorders that may emerge in the medium and long term after an infection remains to be explored
AU  - Fiorina, Laurent
AU  - Younsi, Salem
AU  - Horvilleur, Jérôme Manenti
AU  - Vladimir, Lacotte
AU  - Jérôme, Raimondo
AU  - Cristina, Chemaly
AU  - Pascale, Salerno
AU  - Fiorella, Said
AU  - Mina, Ait
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 et troubles du rythme
T2  - Annales de Cardiologie et d'Angéiologie
TI  - COVID-19 et troubles du rythme
UR  - https://doi.org/10.1016/j.ancard.2020.09.042
ID  - 7793242
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 predominantly affects the lungs but direct or indirect involvement of other organs is increasingly recognized [1]. This article is protected by copyright. All rights reserved.
AD  - Klinik Landstrasse, Messerli Institute, Vienna, Austria.
AN  - 33022810
AU  - Finsterer, J.
AU  - Stöllberger, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/jmv.26581
DP  - NLM
ET  - 2020/10/07
J2  - Journal of medical virology
KW  - SARS-Cov-2
coronavirus
stress cardiomyopathy
stunned myocardium
LA  - eng
N1  - 1096-9071
Finsterer, Josef
Orcid: 0000-0003-2839-7305
Stöllberger, Claudia
Letter
United States
J Med Virol. 2020 Oct 6. doi: 10.1002/jmv.26581.
PY  - 2020
SN  - 0146-6615
ST  - SARS-CoV-2 triggered Takotsubo in 38 patients
T2  - Journal of medical virology
TI  - SARS-CoV-2 triggered Takotsubo in 38 patients
ID  - 7790940
ER  - 

TY  - JOUR
AB  - Objective: Emergency Department (ED) attendances with chest pain reduced during the COVID-19 lockdown. To understand factors influencing patient decision to attend hospital, we performed a local service evaluation project in NHS Lothian. Methods: We collated data on online searches and local clinical services on the number of ED presentations and chest pain clinic (CPC) referrals with suspected acute coronary syndrome between January and May 2020 and compared findings with the same period in 2019. We also carried out 28 semi-structured telephone interviews with patients who presented with chest pain during lockdown and in patients with known coronary heart disease under the outpatient care of a cardiologist in April and May 2020. Interviews were audio recorded and salient themes and issues documented as verbatim extracts. Results: Online searches for the term chest pain doubled after 01/03/2020, peaking in week commencing 22/03/2020 and returning to 2019 levels during April 2020. In contrast, chest pain presentations to ED and CPC decreased, with the greatest reduction in the final week of March 2020 (128 v 287 (average weekly ED attendance 2019), and 6 v 23 (average weekly CPC referral 2019)). This aligned with key government messages to Protect the NHS and the NHS is open campaign. Patient interviews revealed three main themes; 1) pandemic help-seeking behaviour2) COVID-19 exposure concerns; 3) favourable Hospital experience if admitted. Conclusions: Dynamic monitoring of public health and media messaging should evaluate public response to healthcare campaigns to ensure the net impact on health, pandemic and non-pandemic related, is optimised.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis was a non-funded projectAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The project was reviewed by the South East Scotland Research Ethics Service and classed as a service evaluation project therefore did not require further ethical review. The project was conducted as a service evaluation project and registered with the local cardiology quality improvement team according to local practice in NHS Lothian.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesA de-identified data set can be made available for sharing upon request.
AU  - Ferry, Amy V.
AU  - Keanie, Collette
AU  - Denvir, Martin A.
AU  - Mills, Nicholas L.
AU  - Strachan, Fiona E.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20203687
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20203687
ST  - Chest pain presentations to hospital during the COVID-19 lockdown: lessons for public health media campaigns (preprint)
T2  - medRxiv
TI  - Chest pain presentations to hospital during the COVID-19 lockdown: lessons for public health media campaigns (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20203687.abstract
ID  - 7794746
ER  - 

TY  - JOUR
AB  - BACKGROUND: Awake prone positioning (awake-PP) in non-intubated coronavirus disease 2019 (COVID-19) patients could avoid endotracheal intubation, reduce the use of critical care resources, and improve survival. We aimed to examine whether the combination of high-flow nasal oxygen therapy (HFNO) with awake-PP prevents the need for intubation when compared to HFNO alone. METHODS: Prospective, multicenter, adjusted observational cohort study in consecutive COVID-19 patients with acute respiratory failure (ARF) receiving respiratory support with HFNO from 12 March to 9 June 2020. Patients were classified as HFNO with or without awake-PP. Logistic models were fitted to predict treatment at baseline using the following variables: age, sex, obesity, non-respiratory Sequential Organ Failure Assessment score, APACHE-II, C-reactive protein, days from symptoms onset to HFNO initiation, respiratory rate, and peripheral oxyhemoglobin saturation. We compared data on demographics, vital signs, laboratory markers, need for invasive mechanical ventilation, days to intubation, ICU length of stay, and ICU mortality between HFNO patients with and without awake-PP. RESULTS: A total of 1076 patients with COVID-19 ARF were admitted, of which 199 patients received HFNO and were analyzed. Fifty-five (27.6%) were pronated during HFNO; 60 (41%) and 22 (40%) patients from the HFNO and HFNO + awake-PP groups were intubated. The use of awake-PP as an adjunctive therapy to HFNO did not reduce the risk of intubation [RR 0.87 (95% CI 0.53-1.43), p�?�?.60]. Patients treated with HFNO + awake-PP showed a trend for delay in intubation compared to HFNO alone [median 1 (interquartile range, IQR 1.0-2.5) vs 2 IQR 1.0-3.0] days (p�?�?.055), but awake-PP did not affect 28-day mortality [RR 1.04 (95% CI 0.40-2.72), p�?�?.92]. CONCLUSION: In patients with COVID-19 ARF treated with HFNO, the use of awake-PP did not reduce the need for intubation or affect mortality.
AD  - Department of Anesthesiology and Critical Care, Hospital Cl�Tnic, Institut D'investigaci�Q August Pi i Sunyer, Villarroel 170, 08036, Barcelona, Spain. cafeoranestesia@gmail.com.
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain. cafeoranestesia@gmail.com.
Department of Anesthesiology and Critical Care, Hospital Cl�Tnic, Institut D'investigaci�Q August Pi i Sunyer, Villarroel 170, 08036, Barcelona, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
Ubikare Technology, Vizcaya, Spain.
Department of Anesthesiology and Critical Care, Hospital Universitario R�To Hortega, Valladolid, Spain.
Department of Anesthesiology and Critical Care, Hospital del Mar, Barcelona, Spain.
Department of Anesthesiology and Critical Care, Hospital Universitario La Princesa, Madrid, Spain.
Department of Anesthesiology and Intensive Care, Cl�Tnica Universitaria de Navarra, Pamplona, Spain.
Department of Anesthesiology and Critical Care, Hospital Universitario La Paz, Madrid, Spain.
Department of Anesthesiology and Critical Care, Hospital Universitario de Cruces, Barakaldo, Vizcaya, Spain.
Department of Anesthesiology and Critical Care, Hospital Universitario Ram�Qn y Cajal, Madrid, Spain.
Department of Respiratory Care, Massachusetts General Hospital, Boston, MA, USA.
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain.
Intensive Care Unit, Hospital Universitario La Princesa, Madrid, Spain.
AN  - 33023669
AU  - Ferrando, C.
AU  - Mellado-Artigas, R.
AU  - Gea, A.
AU  - Arruti, E.
AU  - Aldecoa, C.
AU  - Adalia, R.
AU  - Ramasco, F.
AU  - Monedero, P.
AU  - Maseda, E.
AU  - Tamayo, G.
AU  - Hern֙ndez-Sanz, M. L.
AU  - Mercadal, J.
AU  - Mart�Tn-Grande, A.
AU  - Kacmarek, R. M.
AU  - Villar, J.
AU  - Su֙rez-Sipmann, F.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13054-020-03314-6
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Critical care (London, England)
KW  - Acute respiratory failure
Covid-19
Critical care
High-flow nasal oxygen therapy
Mechanical ventilation
Prone positioning
LA  - eng
N1  - 1466-609x
Ferrando, Carlos
Orcid: 0000-0002-1907-5323
Mellado-Artigas, Ricard
Gea, Alfredo
Arruti, Egoitz
Aldecoa, César
Adalia, Ram�Qn
Ramasco, Fernando
Monedero, Pablo
Maseda, Emilio
Tamayo, Gonzalo
Hern֙ndez-Sanz, Mar�Ta L
Mercadal, Jordi
Mart�Tn-Grande, Ascensi�Qn
Kacmarek, Robert M
Villar, Jesús
Su֙rez-Sipmann, Fernando
COVID-19 Spanish ICU Network
Journal Article
England
Crit Care. 2020 Oct 6;24(1):597. doi: 10.1186/s13054-020-03314-6.
PY  - 2020
SN  - 1364-8535
SP  - 597
ST  - Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study
T2  - Critical care (London, England)
TI  - Awake prone positioning does not reduce the risk of intubation in COVID-19 treated with high-flow nasal oxygen therapy: a multicenter, adjusted cohort study
VL  - 24
ID  - 7790891
ER  - 

TY  - JOUR
AU  - Ferneini, Elie M.
AU  - Halepas, Steven
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Flawed Research in the Era of the COVID Pandemic
T2  - American Journal of Cosmetic Surgery
TI  - Flawed Research in the Era of the COVID Pandemic
UR  - https://doi.org/10.1177/0748806820964656
ID  - 7792831
ER  - 

TY  - JOUR
AU  - Fenley, Vanessa M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Everyday citizenship and COVID-19: “Staying at home�?while homeless
T2  - Administrative Theory & Praxis
TI  - Everyday citizenship and COVID-19: “Staying at home�?while homeless
UR  - https://doi.org/10.1080/10841806.2020.1825600
ID  - 7792965
ER  - 

TY  - JOUR
AB  - Background Public health agencies had to respond swiftly to the novel coronavirus that emerged in 2019 (COVID-19) to try to contain the virus, which requires early identification of new cases Monitoring exposed individuals is labor intensive and available tools are often limited MITRE, a company that operates federally funded research and development centers for the U S government, rapidly developed a configurable monitoring tool that allows public health authorities to monitor potentially exposed individuals in their jurisdictions Methods A team, including public health leaders, field epidemiologists, software engineers, and health communication specialists, was quickly assembled to design and develop an open source, disease-independent monitoring tool called Sara Alert Outreach to key public health stakeholders, including partner organizations and local and state health departments, was conducted early for requirements gathering and to validate assumptions Public health law experts were consulted regarding data privacy and security Results By four weeks, a minimally viable monitoring tool was available for testing by public health partners Exposed individuals can be enrolled and reminded daily to enter a temperature and any symptoms by web or mobile interface, SMS messaging or phone Public health officials monitor and can quickly take action if symptoms consistent with COVID-19 are reported of if there is failure to report within a configurable time frame Dashboards provide insight into aggregated data appropriate to level of view Conclusions Sara Alert serves as a force multiplier that supports disease containment and allows resources to be directed where they are most needed Successful development was possible because key stakeholders across public health practice were consulted early Sara Alert is available, free, to state and local public health departments and serves as an enduring resource easily configured for the next public health emergency Key messages Sara Alert serves as a force multiplier that supports disease containment and allows resources to be directed where they are most needed Sara Alert serves as an enduring resource easily configured for the next public health emergency
AU  - Feldman, K.
AU  - Butler, M.
AU  - Hay, K.
AU  - Holmes, A.
AU  - Krautscheid, P.
AU  - Nosal, M.
AU  - Scannell, D.
AU  - Sleeper, H.
AU  - Stoutenburg, S.
AU  - Jarris, P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Sara Alert: An enduring national resource to support public health monitoring & disease containment
T2  - European Journal of Public Health
TI  - Sara Alert: An enduring national resource to support public health monitoring & disease containment
UR  - https://doi.org/10.1093/eurpub/ckaa165.353
ID  - 7792915
ER  - 

TY  - JOUR
AB  - Background Prior research has identified higher rates of COVID-19 mortality among people of color (relative to non-Hispanic whites) and populations in high-poverty neighborhoods (relative to wealthier neighborhoods). It is unclear, however, whether non-Hispanic whites in high-poverty neighborhoods experience elevated mortality, or whether people of color living in wealthy areas are relatively protected. Exploring socioeconomic position in combination with race/ethnicity can lead to a more detailed understanding of the specific processes that result in COVID-19 inequities. Methods and Findings We used census and individual-level mortality data for the non-Hispanic white, non-Hispanic Black, and Hispanic/Latinx populations of Cook County, Illinois, USA. We excluded deaths related to nursing homes and other institutions. We calculated age and gender-adjusted mortality rates by race/ethnicity, census tract poverty quartile, and age group (0-64 and �?5 years). Within all racial/ethnic groups, COVID-19 mortality rates were greatest in the highest-poverty quartile and lowest in the lowest-poverty quartile. The mortality rate for younger non-Hispanic whites in the highest-poverty quartile was 13.5 times that of younger non-Hispanic whites in the lowest-poverty quartile (95% CI: 8.5, 21.4). For young people in the highest-poverty quartile, the non-Hispanic white and Black mortality rates were similar. Among younger people in the lowest-poverty quartile, non-Hispanic Black and Hispanic/Latinx people had mortality rates nearly three times that of non-Hispanic whites. For the older population, the mortality rate among non-Hispanic whites in the highest-poverty quartile was less than that of lowest-poverty non-Hispanic Black and Hispanic/Latinx populations. Conclusions Our findings suggest racial/ethnic inequalities in COVID-19 mortality are partly, but not entirely, attributable to the higher average socioeconomic position of non-Hispanic whites relative to the non-Hispanic Black and Hispanic/Latinx populations. Future research on health equity in COVID-19 outcomes should collect and analyze individual-level data on the potential mechanisms driving population distributions of exposure, severe illness, and death.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis study received no external funding.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Neither approval nor exemption by an IRB was required because the study solely analyzed public-use data.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData available on request to the author.
AU  - Feldman, Justin M.
AU  - Bassett, Mary T.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206318
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206318
ST  - The relationship between neighborhood poverty and COVID-19 mortality within racial/ethnic groups (Cook County, Illinois) (preprint)
T2  - medRxiv
TI  - The relationship between neighborhood poverty and COVID-19 mortality within racial/ethnic groups (Cook County, Illinois) (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206318.abstract
ID  - 7794771
ER  - 

TY  - JOUR
AD  - Department of Dermatology, La Paz University Hospital, Madrid, Spain. Electronic address: marta8marta@hotmail.com.
Department of Dermatology, La Paz University Hospital, Madrid, Spain.
Department of Clinical Immunology, La Paz University Hospital, Madrid, Spain.
Department of Microbiology, La Paz University Hospital, Madrid, Spain.
Department of Pathology, La Paz University Hospital, Madrid, Spain.
Department of Pathology, Doce de Octubre University Hospital, Madrid, Spain.
Department of Ophthalmology, La Paz University Hospital, Madrid, Spain.
Department of Vascular Surgery, La Paz University Hospital, Madrid, Spain.
Department of Hematology, La Paz University Hospital, Madrid, Spain.
AN  - 33022305
AU  - Feito-Rodr�Tguez, M.
AU  - Mayor-Ibarguren, A.
AU  - Hij�Qn, C.
AU  - Montero-Vega, D.
AU  - Servera-Negre, G.
AU  - Ruiz-Bravo, E.
AU  - Nozal, P.
AU  - Rodr�Tguez-Peralto, J. L.
AU  - Enguita, A. B.
AU  - Bravo-Gallego, L. Y.
AU  - Granados-Fern֙ndez, M.
AU  - Fern֙ndez-Alcalde, C.
AU  - Fern֙ndez-Heredero, A.
AU  - Alonso-Riaño, M.
AU  - Jiménez-Yuste, V.
AU  - Nuño-Gonz֙lez, A.
AU  - De Lucas-Laguna, R.
AU  - L�Qpez-Granados, E.
AU  - Herranz-Pinto, P.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.jaad.2020.09.086
DP  - NLM
ET  - 2020/10/07
J2  - Journal of the American Academy of Dermatology
KW  - Covid-19
Chilblains
Pernio
SARS-CoV-2
LA  - eng
N1  - 1097-6787
Feito-Rodr�Tguez, M
Mayor-Ibarguren, A
Hij�Qn, C֙mara
Montero-Vega, D
Servera-Negre, G
Ruiz-Bravo, E
Nozal, P
Rodr�Tguez-Peralto, J L
Enguita, A B
Bravo-Gallego, L Y
Granados-Fern֙ndez, M
Fern֙ndez-Alcalde, C
Fern֙ndez-Heredero, A
Alonso-Riaño, M
Jiménez-Yuste, V
Nuño-Gonz֙lez, A
De Lucas-Laguna, R
L�Qpez-Granados, E
Herranz-Pinto, P
Journal Article
United States
J Am Acad Dermatol. 2020 Oct 3:S0190-9622(20)32687-6. doi: 10.1016/j.jaad.2020.09.086.
PY  - 2020
SN  - 0190-9622
ST  - CHILBLAIN-LIKE LESIONS AND COVID-19 INFECTION: A PROSPECTIVE OBSERVATIONAL STUDY AT SPAIN´S GROUND ZERO
T2  - Journal of American Academy of Dermatology
TI  - CHILBLAIN-LIKE LESIONS AND COVID-19 INFECTION: A PROSPECTIVE OBSERVATIONAL STUDY AT SPAIN´S GROUND ZERO
ID  - 7790967
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease, which started in Wuhan, Chin, has now become a public health challenge in most countries around the world Proper preventive measures are necessary to prevent the spread of the virus to help control the pandemic Because, SARS-CoV-2 is new, its transmission route has not been fully understood In this study, we aimed to investigate the presence of SARS‐CoV�? in the sweat secretion of COVID�?9 patients Sweat specimens of 25 COVID- 19 patients were collected and tested for SARS‐CoV�? RNA by Real‐time Polymerase Chain Reaction (RT-PCR) method After RNA extraction and cDNA amplification, all samples were examined for the presence of ORF-1ab and N genes related to COVID-19 Results annotated by Realtime PCR machines software based on Dynamic algorithm The results of this study showed the absence of SARS-CoV-2 in the sweat samples taken from the foreheads of infected people Therefore, it can be concluded that the sweat of patients with COVID- 19 cannot transmit SARS-CoV-2 However they can be easily contaminated with other body liquids
AU  - Fathizadeh, Hadis
AU  - Taghizadeh, Sepehr
AU  - Safari, Rohollah
AU  - Khiabani, Saeid Shabestari
AU  - Babak, Bayaz
AU  - Hamzavi, Fatemeh
AU  - Ganbarov, Khudaverdi
AU  - Esposito, Silvano
AU  - Zeinalzadeh, Elham
AU  - Dao, Sounkalo
AU  - Köse, Şükran Kafil
AU  - Hossein, Samadi
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Study presence of COVID-19 (SARS-CoV-2) in the sweat of patients infected with Covid-19
T2  - Microbial Pathogenesis
TI  - Study presence of COVID-19 (SARS-CoV-2) in the sweat of patients infected with Covid-19
UR  - https://doi.org/10.1016/j.micpath.2020.104556
ID  - 7793092
ER  - 

TY  - JOUR
AB  - The coronavirus COVID-19 pandemic is the defining global health crisis of our time and the greatest challenge we have faced since the World Wars; it can attack several systems in the body and has high complications and mortality. COVID-19 can cause venous and arterial thromboembolism due to immobility, high inflammation, extensive intravascular blood coagulation, and hypoxia. In this study, we report 5 cases of adults with COVID-19, hospitalized in Tohid Hospital, Sanandaj, Iran. Three patients were male and two were female. The youngest patient was 20 years old and the oldest was 55 years old. All patients had at least one family member with coronavirus. Fever, chills, muscular pain, cough, and tachypnea were present in all patients. Red blood cell (RBC) was observed in all patients at a low level. Computed tomography (CT) scans of all patients showed abnormal findings in different areas of the brain. These cases indicate that COVID-19 may damage blood vessels in the brain and lead to stroke.
AD  - Department of Radiology, Tohid Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran. GRID: grid.484406.a. ISNI: 0000 0004 0417 6812
School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia. GRID: grid.1005.4. ISNI: 0000 0004 4902 0432
Department of Anatomical Sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. GRID: grid.484406.a. ISNI: 0000 0004 0417 6812
Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. GRID: grid.484406.a. ISNI: 0000 0004 0417 6812
AN  - 33024934
AU  - Fatehi, P.
AU  - Hesam-Shariati, N.
AU  - Abouzaripour, M.
AU  - Fathi, F.
AU  - Hesam Shariati, M. B.
C1  - 10/7/2020
C2  - PMC7529351
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s42399-020-00559-8
DP  - NLM
ET  - 2020/10/08
J2  - SN comprehensive clinical medicine
KW  - Covid-19
Computed tomography
Coronavirus
Ischemic
Stroke
LA  - eng
N1  - 2523-8973
Fatehi, Poya
Hesam-Shariati, Negin
Abouzaripour, Morteza
Fathi, Fardin
Hesam Shariati, Mohammad Bakhtiar
Orcid: 0000-0002-2000-5197
Journal Article
Switzerland
SN Compr Clin Med. 2020 Oct 1:1-6. doi: 10.1007/s42399-020-00559-8.
PY  - 2020
SN  - 2523-8973
SP  - 1-6
ST  - Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series
T2  - SN comprehensive clinical medicine
TI  - Acute Ischemic and Hemorrhagic Stroke and COVID-19: Case Series
ID  - 7790760
ER  - 

TY  - JOUR
AB  - Background: It is clear that in UK healthcare workers, COVID-19 infections and deaths were more likely to be in staff who were of BAME origin. This has led to much speculation about the role of vitamin D in healthcare worker COVID-19 infections. We aimed to determine the prevalence of vitamin D deficiency in NHS staff who have isolated with symptoms suggestive of COVID-19 and relate this to vitamin D status. Methods: We recruited NHS healthcare workers between 12th to 22nd May 2020 as part of the COVID-19 convalescent immunity study (COCO). We measured anti-SARS-Cov-2 antibodies using a combined IgG, IgA and IgM ELISA (The Binding Site). Vitamin D status was determined by measurement of serum 25(OH)D3 using the AB SCIEX Triple Quad 4500 mass spectrometry system. Findings: Of the 392 NHS healthcare workers, 214 (55%) had seroconverted for COVID-19. A total of 61 (15·6%) members of staff were vitamin D deficient (&amp;lt;30 nmol/l) with significantly more staff from BAME backgrounds or in a junior doctor role being deficient. Vitamin D levels were lower in those who were younger, had a higher BMI (&amp;gt;30 kg/m2), and were male. Multivariate analysis revealed that BAME and COVID-19 seroconversion were independent predictors of vitamin D deficiency. Staff who were vitamin D deficient were more likely to self-report symptoms of body aches and pains but importantly not the respiratory symptoms of cough and breathlessness. Vitamin D levels were lower in those COVID-19 positive staff who reported fever, but this did not reach statistical significance. Within the whole cohort there was an increase in seroconversion in staff with vitamin D deficiency compared to those without vitamin D deficiency (n=44/61, 72% vs n=170/331, 51%; p=0· 003); this was particularly marked in the proportion of BAME males who were vitamin D deficient compared to non-vitamin D deficient BAME males (n=17/18, 94% vs n=12/23, 52%; p=0·005). Multivariate analysis revealed that vitamin D deficiency was an independent risk factor for seroconversion (OR 2·6, 95%CI 1·41�?4· 80; p=0·002). Interpretation: In those healthcare workers who have isolated due to symptoms of COVID-19, those of BAME ethnicity are at the highest risk of vitamin D deficiency. Vitamin D deficiency is a risk factor for COVID-19 seroconversion for NHS healthcare workers especially in BAME male staff.Competing Interest StatementMH reports personal fees from Thornton Ross, outside the submitted work. All other authors declare no competing interests.Funding StatementThis study was funded internally by the University of Birmingham and University Hospitals Birmingham NHS Foundation Trust and supported by the National Institute for Health Research (NIHR)/Wellcome Trust Birmingham Clinical Research Facility. AAF and DRT are funded by the Medical Research Council (MR/S002782/1). The Binding Site (Edgbaston, UK) have provided reagents and plates for the SARS-CoV-2 ELISA free of charge.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:London - Camden &amp;amp; Kings Cross Research Ethics CommitteeAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applic ble.YesData are available upon reasonable request. Proposals should be directed to the corresponding author
AU  - Faniyi, Aduragbemi A.
AU  - Lugg, Sebastian T.
AU  - Faustini, Sian E.
AU  - Webster, Craig
AU  - Duffy, Joanne E.
AU  - Hewison, Martin
AU  - Shields, Adrian
AU  - Nightingale, Peter
AU  - Richter, Alex G.
AU  - Thickett, David R.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206706
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206706
ST  - Vitamin D status and seroconversion for COVID-19 in UK healthcare workers who isolated for COVID-19 like symptoms during the 2020 pandemic (preprint)
T2  - medRxiv
TI  - Vitamin D status and seroconversion for COVID-19 in UK healthcare workers who isolated for COVID-19 like symptoms during the 2020 pandemic (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206706.abstract
ID  - 7794745
ER  - 

TY  - JOUR
AB  - Objectives To describe the humoral immune feature of patients with coronavirus disease 2019 (COVID-19) Methods The levels of total immunoglobulins (IgG, IgM, IgA, and IgE), complement (C3, C4) results were retrospectively analyzed in COVID-19 patients Univariable and multivariable logistic regression were performed to explore the risk factors associated with the in-hospital death Result A total of 236 patients were enrolled in this study, of which 169 were transferred to another institution or discharged (survival group) and 67 died in hospital (non-survival group) Compared with survivors, the levels of IgA and IgE in non-survivors increased significantly, and level of complement C3 decreased Non-survivors also showed higher incidence of chest tightness, breath shortness and dyspnoea;higher levels of inflammatory indicators, leukocytes and neutrophils;and low levels of lymphocyte subsets Multivariable regression showed increasing odds of in-hospital death associated with older age (HR: 1 099;95%CI: 1 057-1 143;p &amp;lt; 0 0001), d-dimer greater (HR: 1 294;95%CI: 1 138-1 473;p &amp;lt; 0 0001) and decreased complement C3 level (HR: 0 073;95%CI: 0 007-0 722;p = 0 025) on admission Finally, in survival COVID-19 patients whose humoral immunity was re-examined, C3 levels tended to increase, while in non-survivors it decreased Conclusion Low level of complement C3 may be an alert to the admitted COVID-19 patients with additional management Inhibition of the complement pathway might be an effective therapeutic to COVID-19 patients
AU  - Fang, Shilin
AU  - Wang, Haizhou
AU  - Lu, Li
AU  - Jia, Yifan
AU  - Xia, Zhongyuan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: a retrospective cohort study
T2  - International Immunopharmacology
TI  - Decreased complement C3 levels are associated with poor prognosis in patients with COVID-19: a retrospective cohort study
UR  - https://doi.org/10.1016/j.intimp.2020.107070
ID  - 7793150
ER  - 

TY  - JOUR
AB  - The diffusion of novel SARS-CoV-2 coronavirus over the world generated COVID-19 pandemic event as reported by World Health Organization on March 2020 The huge issue is the high infectivity and the absence of vaccine and customised drugs allowing for hard management of this outbreak, thus a rapid and on site analysis is a need to contain the spread of COVID-19 Herein, we developed an electrochemical immunoassay for rapid and smart detection of SARS-CoV-2 coronavirus in saliva The electrochemical assay was conceived for Spike (S) protein or Nucleocapsid (N) protein detection using magnetic beads as support of immunological chain and secondary antibody with alkaline phosphatase as immunological label The enzymatic by-product 1-naphtol was detected using screen-printed electrodes modified with carbon black nanomaterial The analytical features of the electrochemical immunoassay were evaluated using the standard solution of S and N protein in buffer solution and untreated saliva with a detection limit equal to 19 ng/mL and 8 ng/mL in untreated saliva, respectively for S and N protein Its effectiveness was assessed using cultured virus in biosafety level 3 and in saliva clinical samples comparing the data using the nasopharyngeal swab specimens tested with Real-Time PCR The agreement of the data, the low detection limit achieved, the rapid analysis (30 min), the miniaturization, and portability of the instrument combined with the easiness to use and no-invasive sampling, confer to this analytical tool high potentiality for market entry as the first highly sensitive electrochemical immunoassay for SARS-CoV-2 detection in untreated saliva
AU  - Fabiani, Laura
AU  - Saroglia, Marco
AU  - Galatà, Giuseppe De Santis
AU  - Riccardo, Fillo
AU  - Silvia, Luca
AU  - Vincenzo, Faggioni
AU  - Giovanni, D.
AU  - Amore, Nino
AU  - Regalbuto, Elisa
AU  - Salvatori, Piero
AU  - Terova, Genciana
AU  - Moscone, Danila
AU  - Lista, Florigio
AU  - Arduini, Fabiana
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva
T2  - Biosensors and Bioelectronics
TI  - Magnetic beads combined with carbon black-based screen-printed electrodes for COVID-19: A reliable and miniaturized electrochemical immunosensor for SARS-CoV-2 detection in saliva
UR  - https://doi.org/10.1016/j.bios.2020.112686
ID  - 7793223
ER  - 

TY  - JOUR
AB  - Purpose This study investigates the relationship between parenting practices and children&#039;s screen time following the COVID-19 outbreak Design and methods The population of the present cross-sectional study was the parents of children studying in three randomly-selected schools in the western, eastern and central regions of Turkey The study data were collected between May 15 and 31, 2020, using a descriptive questionnaire form and the Parenting Practices Scale applied to 1115 parents of children between 6 and 13 years of age The data were analyzed using the SPSS 21 0 software package, and with descriptive, correlation and multiple regression analyses Results It was noted that 68% of the mothers did not work, and 40 2% of the fathers had shifted to a flexible work arrangement as a result of the COVID-19 pandemic The study revealed that 89 6% of the families had established ground rules related to screen time, and that the screen time of the children of 71 7% of the families had seen an increase, amounting to 6 42 ±�? 07 h/day Gender, age, household income, mother&#039;s employment status, family&#039;s rules about screen time, and inconsistent parenting practices were defined as significant predictors in the children&#039;s screen time model created for the study Conclusions A vast majority of the participants stated that their children&#039;s screen time had increased during the COVID-19 pandemic Practice implications Screen time should be monitored, the necessary support should be provided to children, and parents should set ground rules for their children&#039;s screen times
AU  - Eyimaya, Aslihan Ozturk
AU  - Irmak, Aylin Yalçin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Relationship between parenting practices and children's screen time during the COVID-19 Pandemic
T2  - Journal of Pediatric Nursing
TI  - Relationship between parenting practices and children's screen time during the COVID-19 Pandemic
UR  - https://doi.org/10.1016/j.pedn.2020.10.002
ID  - 7793080
ER  - 

TY  - JOUR
AB  - The rapidly increasing number of PCR-based SARS-CoV-2 tests as COVID-19 control measures has been leading not only to the discovery of positive results in asymptomatic individuals, but also to the re-testing of persons having contracted (proven or unproven) COVID-19 or having previously tested positive. In the face of interrogations as to the interpretation and management of these types of situations, and given the need to weigh collective and individual risks, we have carried out a review of the literature aimed at responding to the six following questions. Can PCR-based SARS-CoV-2 testing lead to false positives? For how long do the results remain positive? For how long can the results be associated with an actual risk of transmission / with infectivity in a symptomatic person? Is a newly positive PCR-based SARS-CoV-2 test result following one or more negative test results to be associated with a risk of transmission? Is a positive PCR-based SARS CoV-2 test result to be associated with a genuine risk of transmission / with infectivity in an asymptomatic person? Does the presence of antibodies detected by serology attest to control of the infection and consequently to non-contagiousness, even in the event of positive PCR-based SARS-CoV-2 test results? Having been initiated prior to the recently issued recommendations of the Haut Conseil de la Santé Publique (French public health council), this review is aimed at synthesizing practical proposals liable to evolve according to the advancement of scientific knowledge and the overall epidemic context.
AD  - Département d'Infectiologie, CHU de Dijon, 21000 Dijon, France.
Département d'Infectiologie, CHU de Dijon, 21000 Dijon, France. Electronic address: Lionel.piroth@chu-dijon.fr.
AN  - 33022291
AU  - Esteve, C.
AU  - Catherine, F. X.
AU  - Chavanet, P.
AU  - Blot, M.
AU  - Piroth, L.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.medmal.2020.09.014
DP  - NLM
ET  - 2020/10/07
J2  - Medecine et maladies infectieuses
KW  - Covid19
coronavirus
diagnostic
reverse transcriptase PCR
LA  - eng
N1  - 1769-6690
Esteve, C
Catherine, F X
Chavanet, P
Blot, M
Piroth, L
Editorial
France
Med Mal Infect. 2020 Oct 3:S0399-077X(20)30712-5. doi: 10.1016/j.medmal.2020.09.014.
PY  - 2020
SN  - 0399-077x
ST  - How should a positive PCR test result for COVID-19 in an asymptomatic individual be interpreted and managed?
T2  - Medecine et maladies infectieuses
TI  - How should a positive PCR test result for COVID-19 in an asymptomatic individual be interpreted and managed?
ID  - 7790970
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new member of the coronavirus family that can cause coronavirus disease 2019 (COVID-19). COVID-9 has become a global pandemic with severe health issues around the world. Identifying the accurate immunopathogenesis of the COVID-19 and the immune response against SARS-CoV-2 is necessary for the development of therapeutic approaches and rational drug design. This paper aims to overview the updated clinical data on the immunopathogenesis of the COVID-19 and review the innate and adaptive immune response to SARS-CoV-2. Also, challenges of the immune response to SARS-CoV-2 leading to dysfunctional immune response and their contribution to the progression of the disease have been discussed. To achieve a more efficient immune response, multiple methods could be applied, including regulation of the immune response, augmentation of the immune system against the virus, inhibition of the dysfunctional immune checkpoints, and inhibition of the viral replication/infection. Based on the immune response against SARS-CoV-2 and its dysfunction, we introduce potential immunotherapies as well as reviewing recruiting/completed clinical trials of COVID-19.
AD  - Department of Immunology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Immunotherapy Research and Technology Group, Zanjan University of Medical Sciences, Zanjan, Iran.
Cancer Gene Therapy Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Zanjan University of Medical Sciences, Zanjan, Iran.
AN  - 33022076
AU  - Esmaeilzadeh, A.
AU  - Elahi, R.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/jcp.30076
DP  - NLM
ET  - 2020/10/07
J2  - Journal of cellular physiology
KW  - Covid-19
SARS-CoV-2
clinical trial
immunopathogenesis
immunotherapy
LA  - eng
N1  - 1097-4652
Esmaeilzadeh, Abdolreza
Orcid: 0000-0002-5402-3967
Elahi, Reza
Orcid: 0000-0001-9612-2587
Journal Article
Review
United States
J Cell Physiol. 2020 Oct 6. doi: 10.1002/jcp.30076.
PY  - 2020
SN  - 0021-9541
ST  - Immunobiology and immunotherapy of COVID-19: A clinically updated overview
T2  - Journal of cellular physiology
TI  - Immunobiology and immunotherapy of COVID-19: A clinically updated overview
ID  - 7790982
ER  - 

TY  - JOUR
AB  - Background Hospital staff are at high risk of infection during the coronavirus disease (COVID-19) pandemic. We analysed the exposure characteristics, efficacy of protective measures, and transmission dynamics in this hospital-wide prospective seroprevalence study. Methods and Findings Overall, 4554 individuals were tested for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) IgG antibodies using a chemiluminescent immunoassay. Individual risk factors, use of personal protective equipment (PPE), occupational exposure, previous SARS-CoV-2 infection, and symptoms were assessed using a questionnaire and correlated to anti-SARS-CoV-2 IgG antibody titres and PCR testing results. Odds ratios with corresponding exact 95% confidence intervals were used to evaluate associations between individual factors and seropositivity. Spatio-temporal trajectories of SARS-CoV-2-infected patients and staff mobility within the hospital were visualised to identify local hotspots of virus transmission. The overall seroprevalence of anti-SARS-CoV-2-IgG antibody was 2.4% [95% CI 1.9-2.9]. Patient-facing staff, including those working in COVID-19 areas, had a similar probability of being seropositive as non-patient-facing staff. Prior interaction with SARS-CoV-2-infected co-workers or private contacts and unprotected exposure to COVID-19 patients increased the probability of seropositivity. Loss of smell and taste had the highest positive predictive value for seropositivity. The rate of asymptomatic SARS-CoV-2 infections was 25.9%, and higher anti-SARS-CoV-2 IgG antibody titres were observed in symptomatic individuals. Spatio-temporal hotspots of SARS-CoV-2-positive staff and patients only showed partial overlap. Conclusions Patient-facing work in a healthcare facility during the SARS-CoV-2 pandemic may be safe if adequate PPE and hygiene measures are applied. The high numbers of asymptomatic SARS-CoV-2 infections that escaped detection by symptomatic testing underline the value of cross-sectional seroprevalence studies. Unprotected contact is a major risk factor for infection and argues for the rigorous implementation of hygiene measures.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe study was funded by the Board of Directors of the University Hospital rechts der Isar, Munich.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was approved by the Ethics Committee of the Technical University of Munich, School of Medicine (approval number: 216/20S).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAnonymised aggregated data will be available to researchers upon reasonable request, which should be directed to the corresponding author. The source code of the trajectory analysis is available at https://github.com/AnaGalhoz37/SeCOMRI.https://github.com/AnaGalhoz37/SeCOMRI
AU  - Erber, Johanna
AU  - Kappler, Verena
AU  - Haller, Bernhard
AU  - Mijocevic, Hrvoje
AU  - Galhoz, Ana
AU  - Prazeres da Costa, Clarissa
AU  - Gebhardt, Friedemann
AU  - Graf, Natalia
AU  - Hoffmann, Dieter
AU  - Thaler, Markus
AU  - Lorenz, Elke
AU  - Roggendorf, Hedwig
AU  - Kohlmayer, Florian
AU  - Henkel, Andreas
AU  - Menden, Michael M.
AU  - Ruland, Juergen
AU  - Spinner, Christoph D.
AU  - Protzer, Ulrike
AU  - Knolle, Percy
AU  - Lingor, Paul
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206136
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206136
ST  - Strategies for infection control and prevalence of anti-SARS-CoV-2 IgG in 4,554 employees of a university hospital in Munich, Germany (preprint)
T2  - medRxiv
TI  - Strategies for infection control and prevalence of anti-SARS-CoV-2 IgG in 4,554 employees of a university hospital in Munich, Germany (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206136.abstract
ID  - 7794770
ER  - 

TY  - JOUR
AU  - Emery, Logan P.
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - Industry Concentration, Feedback Loops, Internet, Network, COVID-19
PY  - 2020
ST  - Market Dominance in the Digital Age: Online Feedback Loops and Rising Industry Concentration (preprint)
T2  - SSRN
TI  - Market Dominance in the Digital Age: Online Feedback Loops and Rising Industry Concentration (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3695343
ID  - 7794787
ER  - 

TY  - JOUR
AU  - Embregts, Petri J. C. M.
AU  - van den Bogaard, Kim J. H. M.
AU  - Frielink, Noud
AU  - Voermans, Moniek A. C.
AU  - Thalen, Marloes
AU  - Jahoda, Andrew
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A thematic analysis into the experiences of people with a mild intellectual disability during the COVID-19 lockdown period
T2  - International Journal of Developmental Disabilities
TI  - A thematic analysis into the experiences of people with a mild intellectual disability during the COVID-19 lockdown period
UR  - https://doi.org/10.1080/20473869.2020.1827214
ID  - 7792943
ER  - 

TY  - JOUR
AB  - Summary Background Novel coronavirus (COVID-19) and subsequent quarantine could raise the risk of food inadequacy and nutrition deficiency crises Objectives This study aimed to assess the impacts of COVID-19 on household food security in Jordan, determined the percentage of food security and the levels of food insecurity during the quarantine, determined the associated factor with food insecurity, and determined main food groups associated with FINS during the quarantine Design A cross-sectional study was conducted using a Web-based validated questionnaire The Food Insecurity Experience Scale was used to measure the food insecurity during the first four weeks of the quarantine, and a modified food consumption score was used to determine the number of times the household consumes each food group Univariate and multiple logistic regression models were used to describe, explore, and predict risk factors correlated with food insecurity among Jordanians, during the first four weeks of the quarantine Results A total of 3129 Jordanians had responded to the assessment and fully answered the questionnaire 23 1% of the total participants were severe food insecure, while 36 1% were moderate food insecure, 40 7% were food secure The regression model demonstrated the monthly income per capita below the poverty line and a number of the family member (1�? and 5�?) associated significantly with moderate food insecurity (OR: 5 33;95% CI: 4 44�? 40, OR: 0 64;95% CI: 0 47�? 86, OR: 0 76;95% CI: 0 58�? 98, respectively) As well as with the severe food insecurity (OR: 6 87;95% CI: 5 542�? 512, OR: 0 52;95% CI: 0 37�? 74, 0 64;95% CI: 0 48�? 87, respectively) Age 18�?0 years old (OR: 1 80;95% CI: 1 23�? 65) and living in a rented house (OR: 1 30;95% CI: 1 01�? 69) were associated significantly with severe food insecurity Carbohydrates and the meat group were significantly related to food insecurity (p-value was &amp;lt;0 001 for both groups) Conclusion Covid-19 and its subsequent quarantine have a tangible impact on food security levels for the populations Awareness and strategies to support individuals at higher risks should be guided not only by the income but also by other risk factors identified in the present study as the number of persons in the family, younger adults (18�?0 years old), and those who do not own their houses)
AU  - Elsahoryi, Nour
AU  - Al-Sayyed, Hiba
AU  - Odeh, Mohanad
AU  - McGrattan, Andrea
AU  - Hammad, Fwziah
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Effect of Covid-19 on food security y: A cross-sectional survey
T2  - Clinical Nutrition ESPEN
TI  - Effect of Covid-19 on food security y: A cross-sectional survey
UR  - https://doi.org/10.1016/j.clnesp.2020.09.026
ID  - 7793201
ER  - 

TY  - JOUR
AB  - There has been rapid development of clinical trials conducted on antivirals, immunomodulators, and other therapies against COVID-19. The rising number of trials has led to duplication and a need for curation of available outcomes from treatments that have been followed across the world. The rising number of trials has led to duplication and a need for curation of available outcomes from treatments that have been followed across the world. We have conducted a systematic review and meta analysis that focus on evaluating the clinical outcomes of repurposed drugs against COVID-19 including Tocilizumab, Remdesivir, Dexamethasome, Lopinavir-ritonavir, Favipiravir, Hydroxychloroquine, and Convalescent plasma therapy. Twenty-nine articles were included in this study after thorough literature search and performed subgroup analyses based on disease severity levels. Random effects model was adopted to estimate overall treatment effect and heterogeneity. Subgroup analysis on mortality rate showed significant overall effect in the treatment group of studies having critically ill patients (p&amp;lt;0.01).Overall, our study confirmed that tocilizumab may probably reduce the mortality (&amp;lt;10%) of patients with COVID-19 with faster recovery time and reduce the risk of patients with lung disease in falling into oxygen support (P = 0.02). Patients on remedesivir showed no significant associations of comorbidities with risk of falling into oxygen supports. Hydroxychloroquine was found to be inefficacious in COVID-19 patients (OR 0.64; 95%CI [0.47-0.86]).Dexamethasone had marginal effect on overall mortality rate (OR 1.19; 95%CI [1.05-1.35]), and hence helpful for patients on mechanical ventilation or ECMO. There was also evidence suggesting that combination therapies (serpin + Favipiravir) were helpful in reducing the mortality rate in COVID-19 patients under invasive support.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe authors received no funding for this work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This analysis do not require approval from ethical guidelines as the work did not involve patients directlyAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData can be accessed on request
AU  - Elangovan, Esther Jebarani
AU  - Kumar, Vanitha Shyamili
AU  - Kathiravan, Adhithyan
AU  - Mallampalli, Raghav
AU  - Thomas, Tiju
AU  - Subramaniyam, Gnanasambandam
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206516
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206516
ST  - Rationale and prognosis of repurposed drugs with risk stratification of patients in oxygen support in COVID-19: A systematic review and meta-analysis (preprint)
T2  - medRxiv
TI  - Rationale and prognosis of repurposed drugs with risk stratification of patients in oxygen support in COVID-19: A systematic review and meta-analysis (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206516.abstract
ID  - 7794759
ER  - 

TY  - JOUR
AB  - BACKGROUND: Animal models of COVID-19 have been rapidly reported after the start of the pandemic. We aimed to assess whether the newly created models reproduce the full spectrum of human COVID-19. METHODS: We searched the MEDLINE, as well as BioRxiv and MedRxiv preprint servers for original research published in English from January 1 to May 20, 2020. We used the search terms (COVID-19) OR (SARS-CoV-2) AND (animal models), (hamsters), (nonhuman primates), (macaques), (rodent), (mice), (rats), (ferrets), (rabbits), (cats), and (dogs). Inclusion criteria were the establishment of animal models of COVID-19 as an endpoint. Other inclusion criteria were assessment of prophylaxis, therapies, or vaccines, using animal models of COVID-19. RESULT: Thirteen peer-reviewed studies and 14 preprints met the inclusion criteria. The animals used were nonhuman primates (n�?�?3), mice (n�?�?), ferrets (n�?�?), hamsters (n�?�?), and cats (n�?�?). All animals supported high viral replication in the upper and lower respiratory tract associated with mild clinical manifestations, lung pathology, and full recovery. Older animals displayed relatively more severe illness than the younger ones. No animal models developed hypoxemic respiratory failure, multiple organ dysfunction, culminating in death. All species elicited a specific IgG antibodies response to the spike proteins, which were protective against a second exposure. Transient systemic inflammation was observed occasionally in nonhuman primates, hamsters, and mice. Notably, none of the animals unveiled a cytokine storm or coagulopathy. CONCLUSIONS: Most of the animal models of COVID-19 recapitulated mild pattern of human COVID-19 with full recovery phenotype. No severe illness associated with mortality was observed, suggesting a wide gap between COVID-19 in humans and animal models.
AD  - Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.
Experimental Medicine Department, King Abdullah International Medical Research Center/King Saud bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia. bouchamaab@NGHA.MED.SA.
AN  - 33023604
AU  - Ehaideb, S. N.
AU  - Abdullah, M. L.
AU  - Abuyassin, B.
AU  - Bouchama, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13054-020-03304-8
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Critical care (London, England)
KW  - Animal models
Covid-19
Ferrets
Hamster
Non-human primate
Review
Rodent
SARS-CoV-2
LA  - eng
N1  - 1466-609x
Ehaideb, Salleh N
Abdullah, Mashan L
Abuyassin, Bisher
Bouchama, Abderrezak
Orcid: 0000-0003-3089-5936
Journal Article
England
Crit Care. 2020 Oct 6;24(1):594. doi: 10.1186/s13054-020-03304-8.
PY  - 2020
SN  - 1364-8535
SP  - 594
ST  - Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review
T2  - Critical care (London, England)
TI  - Evidence of a wide gap between COVID-19 in humans and animal models: a systematic review
VL  - 24
ID  - 7790900
ER  - 

TY  - JOUR
AU  - Ealy, Julie B.
AU  - Stauffer, Jessica
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Correction to “Reflections of an ACS Affiliated Liaison during Covid-19: A University and AP Chemistry AACT Team�?
T2  - Journal of Chemical Education
TI  - Correction to “Reflections of an ACS Affiliated Liaison during Covid-19: A University and AP Chemistry AACT Team�?
UR  - https://doi.org/10.1021/acs.jchemed.0c01203
ID  - 7793004
ER  - 

TY  - JOUR
AB  - The COVID-19 crisis revealed that business scholars are painfully and perhaps unnecessarily slow at producing academic content Rather than make excuses, let?s move towards more nimble scholarship
AU  - Dykes, Bernadine J.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Nimble Scholarship by Necessity
T2  - Journal of Management Inquiry
TI  - Nimble Scholarship by Necessity
UR  - https://doi.org/10.1177/1056492620957907
ID  - 7792816
ER  - 

TY  - JOUR
AD  - CHU Clermont-Ferrand, University Hospital of Clermont-Ferrand, Preventive and Occupational Medicine, CNRS, LaPSCo, Physiological and Psychosocial Stress, Witty Fit, Université Clermont Auvergne, 58 rue Montalembert, F-63000, Clermont-Ferrand, France. fdutheil@chu-clermontferrand.fr.
Department of Sport, Physical Education and Health, Centre for Health and Exercise Science Research, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
Université Clermont Auvergne, CNRS, INSERM, GReD, Translational Approach to Epithelial Injury and Repair, CHU Clermont-Ferrand, Ophthalmology, University Hospital of Clermont-Ferrand, F-63000, Clermont-Ferrand, France.
AN  - 33025440
AU  - Dutheil, F.
AU  - Baker, J. S.
AU  - Navel, V.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11356-020-11075-6
DP  - NLM
ET  - 2020/10/08
J2  - Environmental science and pollution research international
LA  - eng
N1  - 1614-7499
Dutheil, Frédéric
Orcid: 0000-0002-1468-6029
Baker, Julien S
Navel, Valentin
Orcid: 0000-0001-6317-345x
Letter
Germany
Environ Sci Pollut Res Int. 2020 Oct 6. doi: 10.1007/s11356-020-11075-6.
PY  - 2020
SN  - 0944-1344
ST  - COVID-19 and air pollution: the worst is yet to come
T2  - Environmental science and pollution research international
TI  - COVID-19 and air pollution: the worst is yet to come
ID  - 7790706
ER  - 

TY  - JOUR
AU  - Duggan, Nicole M.
AU  - Wilcox, Susan R.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Response to case comparisons and a new definition of disease-free status
T2  - American Journal of Emergency Medicine
TI  - Response to case comparisons and a new definition of disease-free status
UR  - https://doi.org/10.1016/j.ajem.2020.09.071
ID  - 7793255
ER  - 

TY  - JOUR
AB  - At present, no agents are known to be effective in preventing Covid-19. Based on current knowledge of the pathogenesis of this disease, we suggest that SARS-CoV-2 infection might be attenuated by directly maintaining innate pulmonary redox, metabolic and dilation functions using well-tolerated medications that are known to serve these functions, specifically, using a low dose aerosolized combination of glutathione, inosine and potassium. From June 1 to July 10, 2020, we conducted a low-intervention open-label single-centre study to evaluate safety and efficacy of pre-exposure prophylaxis (PrEP) with the aerosolized combination medications (ACM) on SARS-CoV-2 incidence in 99 healthcare workers (HCWs) at a hospital that was designated to treat Covid-19 patients. We also retrospectively compared SARS-CoV-2 incidence in the ACM users to that in 268 untreated HCWs at the same hospital. Eligible participants received an aerosolized combination of 21.3 mg/ml glutathione, 8.7 mg/ml inosine in 107 mM potassium solution for 14 days. The main outcome was the frequency of laboratory confirmed SARS-CoV-2 cases, defined as individuals with positive genetic or immunological tests within 28 days of the study period. During the PrEP period, solicited adverse events occurred in five participants; all were mild and transient reactions. SARS-CoV-2 was detected in 2 ACM users (2%, 95% CI: 0.3% to 7.1%), which was significantly less than the incidence in 24 nonusers (9%, 95% CI: 5.8% to 13.0%; P = 0.02). Our findings might be used either to prevent SARS-CoV-2 infection, or to support ongoing and new research into more effective treatments for Covid-19.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialISRCTN34160010. The study was propsectively registered with rosrid.ru in accordance with national regulations.Funding StatementNo external funding was received.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was reviewed and approved by the Local Ethics Committee at North-Western State Medical University named after I.I. Mechnikov of the Ministry of Health of Russian Federation, St. Petersburg, Russia (4/27-05-2020)All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe datasets generated during and/or analysed during the study are available from the corresponding author on reasonable request.
AU  - Dubina, Michael V.
AU  - Gomonova, Veronika V.
AU  - Taraskina, Anastasia E.
AU  - Vasilyeva, Natalia V.
AU  - Sayganov, Sergey A.
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.09.25.20199562
DP  - medRxiv
PY  - 2020
SP  - 2020.09.25.20199562
ST  - Pathogenesis-based pre-exposure prophylaxis associated with low risk of SARS-CoV-2 infection in healthcare workers at a designated Covid-19 hospital (preprint)
T2  - medRxiv
TI  - Pathogenesis-based pre-exposure prophylaxis associated with low risk of SARS-CoV-2 infection in healthcare workers at a designated Covid-19 hospital (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.09.25.20199562.abstract
ID  - 7794729
ER  - 

TY  - JOUR
AD  - Louise C. Druedahl, M.Sc.Pharm., is a Ph.D. candidate at CORS, University of Copenhagen. Audrey Lebret, LL.D., LL.M., MSc.M., is a postdoctoral researcher at CeBIL, University of Copenhagen. Timo Minssen, LL.D., LL.Lic., LL.M., M.I.C.L, Dipl. Jur. is Professor of Law and the Director of CeBIL, University of Copenhagen.
AN  - 33021187
AU  - Druedahl, L. C.
AU  - Lebret, A.
AU  - Minssen, T.
C1  - 10/7/2020
DA  - Sep
DB  - PubMed
DO  - 10.1177/1073110520958884
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
LA  - eng
N1  - 1748-720x
Druedahl, Louise C
Lebret, Audrey
Minssen, Timo
Journal Article
United States
J Law Med Ethics. 2020 Sep;48(3):579-582. doi: 10.1177/1073110520958884.
PY  - 2020
SN  - 1073-1105
SP  - 579-582
ST  - ELSI Implications of Prioritizing Biological Therapies in Times of COVID-19
T2  - Journal of law, medicine & ethics : a journal of American Society of Law, Medicine & Ethics
TI  - ELSI Implications of Prioritizing Biological Therapies in Times of COVID-19
VL  - 48
ID  - 7791043
ER  - 

TY  - JOUR
AB  - BACKGROUND: In healthcare, the goal of personal protective equipment (PPE) is to protect healthcare personnel (HCP) and patients from body fluids and infectious organisms via contact, droplet, or airborne transmission. The critical importance of using PPE properly is highlighted by 2 potentially fatal viral infections, severe acute respiratory syndrome-associated coronavirus and Ebola virus, where HCP became infected while caring for patients due to errors in the use of PPE. However, PPE in dealing with less dangerous, but highly infectious organisms is important as well. This work proposes a framework to test and evaluate PPE with a focus on gown design.
METHODS: An observational study identified issues with potential for contamination related to gown use. After redesigning the existing gown, a high-fidelity patient simulator study with 40 HCP as participants evaluated the gown redesign using 2 commonly performed tasks. Variables of interest were nonadherence to procedural standards, use problems with the gown during task performance, and usability and cognitive task load ratings of the standard and redesigned gowns.
RESULTS: While no differences were found in terms of nonadherence and use problems between the current and the redesigned gown, differences in usability and task load ratings suggested that the redesigned gown is perceived more favorably by HCP.
CONCLUSIONS: This work proposes a framework to guide the evaluation of PPE. The results suggest that the current design of the PPE gown can be improved in usability and user satisfaction. Although our data did not find an increase in adherence to protocol when using the redesigned gown, it is likely that higher usability and lower task load could result in higher adherence over longer periods of use.
AD  - Drews, Frank A. Department of Psychology, Department of Internal Medicine, University of Utah, Salt Lake City.
Drews, Frank A. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City.
Mulvey, Diane. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City.
Stratford, Kristina. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City.
Samore, Matthew H. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City.
Mayer, Jeanmarie. Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City.
AN  - 31517973
AU  - Drews, F. A.
AU  - Mulvey, D.
AU  - Stratford, K.
AU  - Samore, M. H.
AU  - Mayer, J.
C1  - 10/7/2020
DA  - 09 13
DB  - MEDLINE
DO  - https://dx.doi.org/10.1093/cid/ciz520
DP  - Ovid Technologies
IS  - Suppl 3
J2  - Clin Infect Dis
KW  - *Cross Infection/pc [Prevention & Control]
Cross Infection/tm [Transmission]
Evaluation Studies as Topic
*Health Personnel/sn [Statistics & Numerical Data]
Hemorrhagic Fever, Ebola/pc [Prevention & Control]
Hemorrhagic Fever, Ebola/tm [Transmission]
Humans
*Infectious Disease Transmission, Patient-to-Professional/pc [Prevention & Control]
*Personal Protective Equipment/st [Standards]
*Protective Clothing/st [Standards]
Severe Acute Respiratory Syndrome/pc [Prevention & Control]
Severe Acute Respiratory Syndrome/tm [Transmission]
*Virus Diseases/pc [Prevention & Control]
Virus Diseases/tm [Transmission]
LA  - English
M3  - Observational Study
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
N1  - Drews, Frank A
Mulvey, Diane
Stratford, Kristina
Samore, Matthew H
Mayer, Jeanmarie
PY  - 2019
SN  - 1537-6591
SP  - S199-S205
ST  - Evaluation of a Redesigned Personal Protective Equipment Gown
T2  - Clinical Infectious Diseases
TI  - Evaluation of a Redesigned Personal Protective Equipment Gown
UR  - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=mesx&AN=31517973
http://sfx.library.cdc.gov/cdc?sid=OVID:medline&id=pmid:31517973&id=10.1093%2Fcid%2Fciz520&issn=1058-4838&isbn=&volume=69&issue=3&spage=S199&pages=S199-S205&date=2019&title=Clinical+Infectious+Diseases&atitle=Evaluation+of+a+Redesigned+Personal+Protective+Equipment+Gown.&aulast=Drews&pid=%3Cauthor%3EDrews+FA%2CMulvey+D%2CStratford+K%2CSamore+MH%2CMayer+J%3C%2Fauthor%3E&%3CAN%3E31517973%3C%2FAN%3E&%3CDT%3EJournal+Article%3C%2FDT%3E
VL  - 69
ID  - 7788918
ER  - 

TY  - JOUR
AB  - IMPORTANCE: Nursing home residents are at heightened risk for morbidity and mortality following an exposure to a disaster such as a hurricane or the COVID19 pandemic. Previous research has shown that nursing home resident mortality related to disasters is frequently underreported. There is a need to better understand the consequences of disasters on nursing home residents and to differentiate vulnerability based on patient characteristics. OBJECTIVE: To evaluate mortality and morbidity associated with exposure to Hurricane Irma, a Category 4 storm that made landfall on September 10, 2017, in Cudjoe Key, Florida, among short-stay (90-day residence) and long-stay (�?0-day residence) residents of nursing homes. DESIGN, SETTING, AND PARTICIPANTS: Cohort study of Florida nursing home residents comparing residents exposed to Hurricane Irma in September 2017 to a control group of residents residing at the same nursing homes over the same time period in calendar year 2015. Data were analyzed from August 28, 2019, to July 22, 2020. EXPOSURE: Residents who experienced Hurricane Irma were considered exposed; those who did not were considered unexposed. MAIN OUTCOME AND MEASURES: Outcome variables included 30-day and 90-day mortality and first hospitalizations after the storm in both the short term and the long term. RESULTS: A total of 61�?64 residents who were present in 640 Florida nursing home facilities on September 7, 2017, were identified. A comparison cohort of 61�?13 residents was evaluated in 2015. Both cohorts were mostly female (2015, 68%; 2017, 67%), mostly White (2015, 79%; 2017, 78%), and approximately 40% of the residents in each group were over the age of 85 years. Compared with the control group in 2015, an additional 262 more nursing home deaths were identified at 30 days and 433 more deaths at 90 days. The odds of a first hospitalization for those exposed (vs nonexposed) were 1.09 (95% CI, 1.05-1.13) within the first 30 days after the storm and 1.05 (95% CI, 1.02-1.08) at 90 days; the odds of mortality were 1.12 (95% CI, 1.05-1.18) at 30 days and 1.07 (95% CI, 1.03-1.11) at 90 days. Among long-stay residents, the odds of mortality for those exposed to Hurricane Irma were 1.18 (95% CI, 1.08-1.29) times those unexposed and the odds of hospitalization were 1.11 (95% CI, 1.04-1.18) times those unexposed in the post 30-day period. CONCLUSIONS AND RELEVANCE: The findings of this study suggest that nursing home residents are at considerable risk to the consequences of disasters. These risks may be underreported by state and federal agencies. Long-stay residents, those who have resided in a nursing home for 90 days or more, may be most vulnerable to the consequences of hurricane disasters.
AD  - School of Public Health, Brown University, Providence, Rhode Island.
Warren Alpert Medical School, Brown University, Providence, Rhode Island.
Providence VAMC, Center of Innovation for Long Term Services and Supports, Providence, Rhode Island.
University of South Florida, School of Aging Studies, Tampa.
University of South Florida, Department of Industrial and Management Systems Engineering, Tampa.
AN  - 33021652
AU  - Dosa, D. M.
AU  - Skarha, J.
AU  - Peterson, L. J.
AU  - Jester, D. J.
AU  - Sakib, N.
AU  - Ogarek, J.
AU  - Thomas, K. S.
AU  - Andel, R.
AU  - Hyer, K.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1001/jamanetworkopen.2020.19460
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - JAMA network open
LA  - eng
N1  - 2574-3805
Dosa, David M
Skarha, Julianne
Peterson, Lindsay J
Jester, Dylan J
Sakib, Nazmus
Ogarek, Jessica
Thomas, Kali S
Andel, Ross
Hyer, Kathryn
Journal Article
United States
JAMA Netw Open. 2020 Oct 1;3(10):e2019460. doi: 10.1001/jamanetworkopen.2020.19460.
PY  - 2020
SN  - 2574-3805
SP  - e2019460
ST  - Association Between Exposure to Hurricane Irma and Mortality and Hospitalization in Florida Nursing Home Residents
T2  - JAMA network open
TI  - Association Between Exposure to Hurricane Irma and Mortality and Hospitalization in Florida Nursing Home Residents
VL  - 3
ID  - 7791016
ER  - 

TY  - JOUR
AB  - BACKGROUND: As the coronavirus disease 2019 (COVID-19) pandemic is sweeping across the globe, there is an urgent need to develop effective vaccines as the most powerful strategy to end the pandemic. This study aimed to examine how factors related to vaccine characteristics, their social normative influence and convenience of vaccination can affect the public's preference for the uptake of the COVID-19 vaccine in China. METHODS: An online discrete choice experiment (DCE) survey was administered to a sample of China's general population. Participants were asked to make a series of hypothetical choices and estimate their preference for different attributes of the vaccine. A mixed logit regression model was used to analyse the DCE data. Willingness to pay for each attribute was also calculated. RESULTS: Data of 1236 participants who provided valid responses were included in the analysis. There was strong public preference for high effectiveness of the vaccine, followed by long protective duration, very few adverse events and being manufactured overseas. Price was the least important attribute affecting the public preference in selecting the COVID-19 vaccine. CONCLUSIONS: The strong public preferences detected in this study should be considered when developing COVID-19 vaccination programme in China. The results provide useful information for policymakers to identify the individual and social values for a good vaccination strategy. PATIENT OR PUBLIC CONTRIBUTION: The design of the experimental choices was fully based on interviews and focus group discussions participated by 26 Chinese people with diverse socio-economic backgrounds. Without their participation, the study would not be possible.
AD  - The Jockey Club School of Public Health & Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Centre for Health Systems and Policy Research, The Chinese University of Hong Kong, Hong Kong SAR, China.
School of Pharmacy, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
School of Medicine and Health Management, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
AN  - 33022806
AU  - Dong, D.
AU  - Xu, R. H.
AU  - Wong, E. L.
AU  - Hung, C. T.
AU  - Feng, D.
AU  - Feng, Z.
AU  - Yeoh, E. K.
AU  - Wong, S. Y.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/hex.13140
DP  - NLM
ET  - 2020/10/07
J2  - Health expectations : an international journal of public participation in health care and health policy
KW  - COVID-19 pandemic
Chinese public
discrete choice experiment
vaccine
willingness to pay
LA  - eng
N1  - 1369-7625
Dong, Dong
Orcid: 0000-0001-9784-6472
Xu, Richard Huan
Orcid: 0000-0002-4720-5172
Wong, Eliza Lai-Yi
Orcid: 0000-0001-9983-6219
Hung, Chi-Tim
Orcid: 0000-0003-2103-8377
Feng, Da
Feng, Zhanchun
Yeoh, Eng-Kiong
Orcid: 0000-0002-1721-9450
Wong, Samuel Yeung-Shan
Orcid: 0000-0003-0934-6385
Journal Article
England
Health Expect. 2020 Oct 6. doi: 10.1111/hex.13140.
PY  - 2020
SN  - 1369-6513
ST  - Public preference for COVID-19 vaccines in China: A discrete choice experiment
T2  - Health expectations : an international journal of public participation in health care and health policy
TI  - Public preference for COVID-19 vaccines in China: A discrete choice experiment
ID  - 7790941
ER  - 

TY  - JOUR
AU  - Dolores Garc�Ta-Cos�To, M.
AU  - Hern֙n, Marta Flores
AU  - Pérez, Pedro Caravaca
AU  - L�Qpez-Medrano, Francisco
AU  - Arribas, Fernando
AU  - Jiménez, Juan Delgado
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Trasplante cardiaco durante la pandemia por coronavirus: organizaci�Qn asistencial y caracter�Tsticas de los pacientes infectados
T2  - Revista Española de Cardiolog�Ta
TI  - Trasplante cardiaco durante la pandemia por coronavirus: organizaci�Qn asistencial y caracter�Tsticas de los pacientes infectados
UR  - https://doi.org/10.1016/j.recesp.2020.08.019
ID  - 7793067
ER  - 

TY  - JOUR
AU  - Dittmayer, Carsten
AU  - Meinhardt, Jenny
AU  - Radbruch, Helena
AU  - Radke, Josefine
AU  - Heppner, Barbara Ingold
AU  - Heppner, Frank L.
AU  - Stenzel, Werner
AU  - Holland, Gudrun
AU  - Laue, Michael
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral
T2  - Lancet
TI  - Why misinterpretation of electron micrographs in SARS-CoV-2-infected tissue goes viral
UR  - https://doi.org/10.1016/S0140-6736(20)32079-1
ID  - 7793021
ER  - 

TY  - JOUR
AB  - Objective Rapid, reliable, and easy-to-implement diagnostics that can be adapted in early SARS-CoV-2 diagnosis are critical to combat the epidemic SARS-CoV-2 nucleocapsid protein (NP) is an ideal target for viral antigen-based detection A rapid and convenient method was developed based on fluorescence immunochromatographic (FIC) assay to detect the SARS-CoV-2 NP antigen However, the accuracy of this diagnostic method needs to be examined Methods This prospective study was carried out between February 10 and 15, 2020 in 7 hospitals of Wuhan and 1 hospital of Chongqing, China Participants with clinically suspected SARS-CoV-2 infection were enrolled NP antigen testing by FIC assay and nucleic acid (NA) testing by RT-PCR were performed simultaneously in a blind manner with the same nasopharyngeal swab sample The diagnostic accuracy of NP antigen testing was calculated by taking NA testing of RT-PCR as reference standard, in which samples with cycle threshold (Ct) value �?40 were interpreted as SARS-CoV-2 positives Results A total of 253 participants were enrolled and 2 participants were excluded from the analyses due to invalid NP testing results Of 251 participants (99 2%) that were included in the diagnostic accuracy analysis, a total of 201 participants (80 1%) had a Ct value �?0 With Ct value 40 as the cut-off of NA testing, the sensitivity, specificity, and percent agreement of the FIC assay was 75 6% (95% CI 69 0%-81 3%), 100% (95% CI 91 1%-100%), and 80 5% (95% CI 75 1%-84 9%), respectively Conclusions With RT-PCR assay as reference standard, NP antigen testing by FIC assay shows high specificity and relative high sensitivity in SARS-CoV-2 diagnosis in the early phase of infection
AU  - Diao, Bo
AU  - Wen, Kun
AU  - Zhang, Ji
AU  - Chen, Jian
AU  - Han, Chao
AU  - Chen, Yongwen
AU  - Wang, Shufeng
AU  - Deng, Guohong
AU  - Zhou, Hongwei
AU  - Wu, Yuzhang
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection
T2  - Clinical Microbiology and Infection
TI  - Accuracy of a nucleocapsid protein antigen rapid test in the diagnosis of SARS-CoV-2 infection
UR  - https://doi.org/10.1016/j.cmi.2020.09.057
ID  - 7793198
ER  - 

TY  - JOUR
AB  - BACKGROUND: There is ample evidence that COVID-19 is significantly less severe in children than in adults and asthma and allergy, the most common chronic disorders in children, are not included in the top 10 comorbidities related to COVID-19 fatalities. Nevertheless, concerns about asthma and allergy are still high.. In order to evaluate the impact of paediatric COVID-19 among Italian paediatricians, we sent a 20-questions anonymous internet-based survey to 250 Italian paediatricians with particular address to allergic symptoms and those affecting the upper airways. METHODS: The questionnaire was conceived and pretested in April 2020, by a working group of experts of the Italian Paediatric Society for Allergy and Immunology (SIAIP), and structured into different sections of 20 categorized and multiple choice questions. The first part included questions about epidemiological data follows by a second part assessing the way to manage a suspected COVID-19 infection and personal experiences about that. The third part concerned questions about patients' clinical characteristics and clinical manifestations. The survey was emailed once between April and mid-May 2020. RESULTS: A total 99 participants had participated in our survey and provided responses to our electronic questionnaire. The distribution of patients reported per month varies significantly according to the geographical area (P�?�?.02). Data confirmed that in the North part of Italy the rate of patients referred is higher than in the rest of Italy. Almost all respondents (98%) reported caring for up to a maximum of 10 infected children and the last 2% more than twenty. Among these patients, according to the 75% of responders, a maximum rate of 20% were affected by allergic rhino-conjunctivitis and in particular in the North of Italy while in the Centre and in the South there was a higher incidence (P�?�?.09). Almost the same applies for asthma, 83% of responders declared that up to a maximum of 20% of affected children were asthmatic, from 20 to 40% for the 13,5% of responders and from 40 to 60% for the last 3,5%. As for the allergic conjunctivitis also for asthma, we found a higher incidence in the Centre and in South than in the North (P�?�?.03). CONCLUSIONS: This study is the first to provide a comprehensive review of COVID-19 knowledge and impact among paediatricians in Italy about allergic asthma and upper airway involvement. From our point of view, it provides important information clearly useful for improving a good practice.
AD  - Department of Pediatrics, Giovanni XXIII Hospital, University of Bari, 70126, Bari, Italy.
Department of Clinical and Experimental Medicine, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy. gf.parisi@policlinico.unict.it.
Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, University of Catania, Viale Carlo Azeglio Ciampi, 95121, Catania, Italy. gf.parisi@policlinico.unict.it.
Department of Pediatrics, Allergology and Immunology Division, Sapienza University, Viale Regina Elena, 324, Rome, Italy.
Department of Woman, Child and Specialized Surgery, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 2, 80138, Naples, Italy.
Primary care pediatrician, Cedegolo, Brescia, Italy.
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Via Francesco Sforza, 28, 20122, Milan, Italy.
Department of Pediatrics, Foundation IRCCS Policlinico San Matteo, University of Pavia, Viale Camillo Golgi 19, 27100, Pavia, Italy.
AN  - 33023616
AU  - Diaferio, L.
AU  - Parisi, G. F.
AU  - Brindisi, G.
AU  - Indolfi, C.
AU  - Marchese, G.
AU  - Ghiglioni, D. G.
AU  - Zicari, A. M.
AU  - Marseglia, G. L.
AU  - Miraglia Del Giudice, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13052-020-00906-4
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Italian journal of pediatrics
KW  - Allergy
Asthma
Covid-19
Children
Coronavirus
Paediatricians
Survey
Upper airway
LA  - eng
N1  - 1824-7288
Diaferio, Lucia
Parisi, Giuseppe Fabio
Orcid: 0000-0003-4291-0195
Brindisi, Giulia
Indolfi, Cristiana
Marchese, Giuseppe
Ghiglioni, Daniele Giovanni
Zicari, Anna Maria
Marseglia, Gian Luigi
Miraglia Del Giudice, Michele
Journal Article
England
Ital J Pediatr. 2020 Oct 6;46(1):146. doi: 10.1186/s13052-020-00906-4.
PY  - 2020
SN  - 1720-8424
SP  - 146
ST  - Cross-sectional survey on impact of paediatric COVID-19 among Italian paediatricians: report from the SIAIP rhino-sinusitis and conjunctivitis committee
T2  - Italian journal of pediatrics
TI  - Cross-sectional survey on impact of paediatric COVID-19 among Italian paediatricians: report from the SIAIP rhino-sinusitis and conjunctivitis committee
VL  - 46
ID  - 7790898
ER  - 

TY  - JOUR
AB  - The SARS-CoV-2 pandemic has already reached 3,207,248 patients with more than 225,000 deaths all over the world. Colorectal cancer is the third most diagnosed cancer worldwide, and the healthcare system is struggling to manage daily activities for elective cancer surgery. This review integrates clinical, microbiological, architectural and surgical aspects to develop indications on strategies to manage colorectal cancer patients and ensure safety during the pandemic. Telephone or virtual clinics must be encouraged and phone follow-up should be implemented. Indications for surgery must be rigorous, balancing the advantage of early surgical treatment and risks of treatment delay. To decrease the occupancy rate of intensive care unit beds, elective surgical treatment should be delayed until local endemic control, according to stage of disease. Patients with SARS-CoV-2 infection should be treated only after clinical recovery, two consecutive negative oropharyngeal swabs and, if available, a negative stool sample. Before any elective oncologic procedure, a multidisciplinary oncologic team including an anaesthesiologist and an infectious disease specialist must assess every patient to evaluate the risk of infection and its impact on perioperative morbidity, mortality and oncologic prognosis. The hospital should organise to manage all elective oncologic patients in an "infection-free" area or refer them to a non-SARS-CoV-2 hospital.
AD  - UOC Chirurgia Generale, Ospedale Valtiberina - Sansepolcro, Usl Toscana Sud-Est.
Dipartimento di Chirurgia "P. Valdoni", "Sapienza" Università di Roma.
UOC Chirurgia Generale, Ospedale di Macerata.
UOC Chirurgia Generale e d'urgenza, AOU Pisa.
UOC Chirurgia Generale e d'urgenza, Ospedale Maggiore, Parma.
Dipartimento Medicina Molecolare, UOC Microbiologia e Virologia "Sapienza" Università di Roma.
UOC Chirurgia Generale, NOA - Marina di Massa, Usl Toscana Nord-Ovest.
Dipartimento Scienze Cliniche e Sperimentali, Università di Brescia.
Associate Architect and Healthcare Lead. Brydenwood. London, UK.
Dipartimento Biotecnologie Mediche, Policlinico Le Scotte, Siena.
AN  - 33021320
AU  - Di Marzo, F.
AU  - Fiori, E.
AU  - Sartelli, M.
AU  - Cennamo, R.
AU  - Coccolini, F.
AU  - Catena, F.
AU  - Calabretto, M.
AU  - Riveros Cabral, R. J.
AU  - Lombardi, M.
AU  - Baiocchi, G. L.
AU  - Cardi, M.
AU  - Cusi, M. G.
AU  - Cardi, M.
C1  - 10/7/2020
DA  - Sep 4
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - The new microbiologica
KW  - Covid surgery
Covid-19
SARS-CoV-2 pandemic
colorectal cancer
colorectal cancer surgery
LA  - eng
N1  - Di Marzo, Francesco
Fiori, Enrico
Sartelli, Massimo
Cennamo, Rosario
Coccolini, Federico
Catena, Fausto
Calabretto, Marianna
Riveros Cabral, Rodolfo Javier
Lombardi, Mirko
Baiocchi, Gian Luca
Cardi, Martina
Cusi, Maria Grazia
Cardi, Maurizio
Journal Article
Italy
New Microbiol. 2020 Sep 4;43(4).
PY  - 2020
SN  - 1121-7138 (Print)
1121-7138
ST  - SARS-CoV-2 pandemic: implications in the management of patients with colorectal cancer
T2  - new microbiologica
TI  - SARS-CoV-2 pandemic: implications in the management of patients with colorectal cancer
VL  - 43
ID  - 7791040
ER  - 

TY  - JOUR
AB  - Current events have put us in front of new paradigms on which our life and its economic aspects seem to be based: the worldwide spread of contagion from COVID-19 threatens dramatic long-term changes in the economy, lifestyle, and social structures Valuing virtuous behaviour through the transfer and sharing of risks among several actors allows us to achieve benefits for all The COVID-19 pandemic leads us to experiment with new forms of public health protection, including through insurance instruments The role of insurance companies, intrinsically linked with the protection of primary areas such as healthcare and welfare, therefore becomes more critical than ever in terms of securing the protection of people, families, and productive activities This work endorses the design of a virtuous cycle of investments, which may be implemented starting with insurance companies;such a project would unfold through insurance policies&amp;rsquo;contractual lines, securitisation schemes, investment policies, and socially responsible corporate strategies
AU  - Di Lorenzo, Emilia
AU  - Sibillo, Marilena
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Economic Paradigms and Corporate Culture after the Great COVID-19 Pandemic: Towards a New Role of Welfare Organisations and Insurers
T2  - Sustainability
TI  - Economic Paradigms and Corporate Culture after the Great COVID-19 Pandemic: Towards a New Role of Welfare Organisations and Insurers
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813195
ID  - 7793363
ER  - 

TY  - JOUR
AB  - Targeting RNA with small molecules holds promise for major therapeutic developments, especially with new chemical modalities such as ribonuclease targeting chimeras (RIBOTACs)
AU  - Di Giorgio, Audrey
AU  - Duca, Maria
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - New Chemical Modalities Enabling Specific RNA Targeting and Degradation: Application to SARS-CoV-2 RNA
T2  - ACS Central Science
TI  - New Chemical Modalities Enabling Specific RNA Targeting and Degradation: Application to SARS-CoV-2 RNA
UR  - https://doi.org/10.1021/acscentsci.0c01187
ID  - 7793002
ER  - 

TY  - JOUR
AB  - The pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine development. Several drugs have been used for the management of coronavirus disease 2019 (COVID-19), which has affected many hospitals and health centers worldwide. Statistically significant results are lacking on the effectiveness of the experimented drugs in reducing COVID-19 morbidity or mortality, as there are very few published randomized clinical trials. Despite this, the literature offers some material for study and reflection. This opinion review attempts to address three burning questions on COVID-19 treatment options. (1) What kind of studies are currently published or ongoing in the treatment of patients with COVID-19? (2) What drugs are currently described in the literature as options of treatment for patients affected by the infection? And (3) Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy? By answering these questions, we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo, and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment.
AD  - Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples 80138, Italy.
Department of Emergency Medicine, Good Samaritan Hospital Medical Center, New York, NY 11795, United States.
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan 20122, Italy.
Division of Infectious Diseases, "San Giuseppe Moscati" Hospital, Avellino 83100, Italy.
Department of Women, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples 80138, Italy. marco.fiore@unicampania.it.
AN  - 33024717
AU  - Di Franco, S.
AU  - Alfieri, A.
AU  - Petrou, S.
AU  - Damiani, G.
AU  - Passavanti, M. B.
AU  - Pace, M. C.
AU  - Leone, S.
AU  - Fiore, M.
C1  - 10/7/2020
C2  - PMC7520874
DA  - Sep 25
DB  - PubMed
DO  - 10.5501/wjv.v9.i3.27
DP  - NLM
ET  - 2020/10/08
IS  - 3
J2  - World journal of virology
KW  - Antiviral drugs
Covid-19
Coronavirus
Eculizumab
Enoxaparin
Hydroxychloroquine
Opinion review
Pandemic
SARS-CoV-2
Tocilizumab
Treatment
LA  - eng
N1  - Di Franco, Sveva
Alfieri, Aniello
Petrou, Stephen
Damiani, Giovanni
Passavanti, Maria Beatrice
Pace, Maria Caterina
Leone, Sebastiano
Fiore, Marco
Journal Article
Review
United States
World J Virol. 2020 Sep 25;9(3):27-37. doi: 10.5501/wjv.v9.i3.27.
PY  - 2020
SN  - 2220-3249 (Print)
2220-3249
SP  - 27-37
ST  - Current status of COVID-19 treatment: An opinion review
T2  - World journal of virology
TI  - Current status of COVID-19 treatment: An opinion review
VL  - 9
ID  - 7790776
ER  - 

TY  - JOUR
AB  - BACKGROUND: The COVID-19 outbreak has affected people's health worldwide. For college students, web-based physical education is a challenge, as these course are normally offered outdoors. OBJECTIVE: The aim of this study was to use data from a web-based survey to evaluate the relationship between the mental health status of college students and their sports-related lifestyles. Problems related to web-based physical education were also examined. METHODS: A web-based survey was conducted by snowball sampling from May 8 to 11, 2020. Demographic data, mental health status, and sports-related lifestyles of college students in Wuhan as well as issues related to web-based physical education were collected. Mental health status was assessed by the Depression, Anxiety, and Stress Scale (DASS-21). RESULTS: The study included 1607 respondents from 267 cities. The average scores of the DASS-21 subscales (2.46 for depression, 1.48 for anxiety, and 2.59 for stress) were significantly lower in our study than in a previous study (P.05). Lower DASS-21 scores were significantly correlated with regular exercise, maintaining exercise habits during the outbreak of COVID-19, exercising more than 1 to 2 times a week, exercise duration 1 hour, and 2000 pedometer steps (all P.05). None of the three forms of web-based physical education was preferred by more than 50% of respondents. Frequent technical problems were confronted by 1087/1607 students (67.6%). Shape-up exercises (846/1607, 52.6%), a designed combination of exercises (710/1607, 44.2%), and Chinese kung fu (559/1607, 34.8%) were suggested sports for web-based physical education. CONCLUSIONS: Mental status was significantly correlated with regular exercise and sufficient exercise duration. Professional physical guidance is needed for college students in selected sports. Exercises not meeting students' preferences, frequent technical problems, and the distant interaction involved in web-based physical education were the main problems that should be solved in future.
AD  - Department of Physical Education, Wuhan University of Technology, Wuhan, China.
Department of Physical Education, Hubei Business College, Wuhan, China.
Department of Physical Education, Jianghan University, Wuhan, China.
Department of Physical Education, Huazhong Agricultural University, Wuhan, China.
Department of Imaging Center, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
AN  - 32997639
AU  - Deng, C. H.
AU  - Wang, J. Q.
AU  - Zhu, L. M.
AU  - Liu, H. W.
AU  - Guo, Y.
AU  - Peng, X. H.
AU  - Shao, J. B.
AU  - Xia, W.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.2196/21301
DP  - NLM
ET  - 2020/10/01
IS  - 10
J2  - Journal of medical Internet research
KW  - Covid-19
college students
global health
mental health
mental status
physical activity
physical education
web-based education
web-based survey
young adults
LA  - eng
N1  - 1438-8871
Deng, Cheng-Hu
Orcid: 0000-0001-7455-707x
Wang, Jing-Qiang
Orcid: 0000-0003-4174-6418
Zhu, Li-Ming
Orcid: 0000-0003-3287-8179
Liu, He-Wang
Orcid: 0000-0001-6470-4507
Guo, Yu
Orcid: 0000-0002-2296-3276
Peng, Xue-Hua
Orcid: 0000-0002-0114-0553
Shao, Jian-Bo
Orcid: 0000-0002-4224-3057
Xia, Wei
Orcid: 0000-0001-7491-8090
Journal Article
Canada
J Med Internet Res. 2020 Oct 5;22(10):e21301. doi: 10.2196/21301.
PY  - 2020
SN  - 1438-8871
SP  - e21301
ST  - Association of Web-Based Physical Education With Mental Health of College Students in Wuhan During the COVID-19 Outbreak: Cross-Sectional Survey Study
T2  - Journal of medical Internet research
TI  - Association of Web-Based Physical Education With Mental Health of College Students in Wuhan During the COVID-19 Outbreak: Cross-Sectional Survey Study
VL  - 22
ID  - 7792623
ER  - 

TY  - JOUR
AB  - Issue COVID-19 pandemic began in Italy on February 20th, 2020 Since the beginning of the emergency Healthcare Workers&#039; (HCWs) involvement was prominent, mainly due to direct assistance to COVID-19 patients Therefore, we implemented a prevention policy for HCW screening through serological and RT-PCR testing Description of the problem HCW screening for SARS-CoV-2 infection is essential for prevention and control of the pandemic Lombardy&#039;s Healthcare authorities settled a screening process for HCWs divided into three steps: 1) body temperature assessment at the beginning and the end of work shift, if fever &amp;gt; 37 5 °C was present the HCW was sent back home and a nasopharyngeal swab was performed;2) progressive recruitment for serological testing;3) on those positive to IgG a nasopharyngeal swab was performed and tested for viral RNA by RT-PCR Results Among 79185 HCW tested, 9589 (12%) were positive on serological IgG testing Of the 9589 positive a nasopharyngeal swab was performed on 6884 Of these 358 (5%) tested positive and the remaining 6526 (95%) negative to RT-PCR We calculated a Positive Predictive Value of 5 2% The rate of positive serological tests for each Healthcare facility varied between 0% and 78% Five percent of all facilities, belonging to Brescia, Bergamo and Cremona area, reported a positivity rate higher than 40% in HCWs A second cluster (18% of all facilities), involving the same geographical area, reported a rate between 20% and 40%, whereas the remaining facilities (76%) of the region a rate &amp;lt;20% Lessons Serological IgG testing can be, if followed by immediate nasopharyngeal swab testing, a valid screening intervention on asymptomatic HCWs especially in a high infection prevalence setting Key messages Serological IgG testing can be, if followed by immediate nasopharyngeal swab testing, a valid screening intervention on asymptomatic HCWs Infection prevention in HCW may benefit from a screening campaign especially in high prevalence settings
AU  - Del Castillo, G.
AU  - Castrofino, A.
AU  - Grosso, F.
AU  - Barone, A.
AU  - Crottogini, L.
AU  - Toso, C.
AU  - Pellegrinelli, L.
AU  - Pariani, E.
AU  - Castaldi, S.
AU  - Cereda, D.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 serological testing for Healthcare Workers in Lombardy, Italy
T2  - European Journal of Public Health
TI  - COVID-19 serological testing for Healthcare Workers in Lombardy, Italy
UR  - https://doi.org/10.1093/eurpub/ckaa165.351
ID  - 7792916
ER  - 

TY  - JOUR
AD  - Department Viroscience, Erasmus MC, Rotterdam, the Netherlands. r.d.devries@erasmusmc.nl.
AN  - 33024093
AU  - de Vries, R. D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41392-020-00338-w
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
de Vries, Rory D
Orcid: 0000-0003-2817-0127
Journal Article
England
Signal Transduct Target Ther. 2020 Oct 6;5(1):224. doi: 10.1038/s41392-020-00338-w.
PY  - 2020
SN  - 2059-3635
SP  - 224
ST  - SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity
T2  - Signal transduction and targeted therapy
TI  - SARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity
VL  - 5
ID  - 7790842
ER  - 

TY  - JOUR
AB  - BACKGROUND: Monitoring of cardiac implantable electronic devices was highly impacted by the COVID-19 pandemic considering the high volume of in-person visits for regular follow-up. Recent recommendations highlight the important role of remote monitoring to prevent exposure to the virus. This study compared remote monitoring of implantable cardioverter defibrillators in patients whose in-person annual visit was substituted for a remote monitoring session with patients who were already scheduled for a remote monitoring session. METHODS: This was a cross-sectional observational study of 329 consecutive patients between March 20(th) and April 24(th) 2020. Group 1 included 131 patients whose in-person annual visit was substituted for a remote monitoring session. Group 2 included 198 patients who underwent a remote monitoring session as scheduled in their usual device follow-up. The time interval since the last in-person visit was 13.3�u 3.2 months in group 1 and 5.9�u 1.7 months in group 2 (p0.01). RESULTS: In group 1, 15 patients (11.5%) experienced a clinical event compared to 15 patients (7,6%) in group 2 (p = 0.25). Nineteen patients (14.5%) required a physician intervention in group 1 compared to 19 patients (9.6%) in group 2 (p = 0.22). Two patients (1.5%) in group 1 and 4 patients (2.0%) in group 2 required an early in-person follow-up visit during the pandemic (p0.99). CONCLUSION: Remote monitoring of implantable cardioverter defibrillators is useful to identify clinical events and allows physicians to treat patients appropriately during the COVID-19 pandemic regardless of the time interval since their last in-person visit. It reduces significantly in-person visit for regular follow-up. This article is protected by copyright. All rights reserved.
AD  - Department of Cardiology, Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.
AN  - 33021739
AU  - De Larochelli؈re, H.
AU  - Champagne, J.
AU  - Sarrazin, J. F.
AU  - Steinberg, C.
AU  - Philippon, F.
AU  - Roy, K.
AU  - Molin, F.
AU  - O'Hara, G.
AU  - Plourde, B.
AU  - Blier, L.
AU  - Nault, I.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/pace.14086
DP  - NLM
ET  - 2020/10/07
J2  - Pacing and clinical electrophysiology : PACE
KW  - Covid-19
Implantable cardioverter defibrillators
Remote monitoring
LA  - eng
N1  - 1540-8159
De Larochelli؈re, Hugo
Orcid: 0000-0002-6816-1033
Champagne, Jean
Sarrazin, Jean-François
Orcid: 0000-0002-1114-0661
Steinberg, Christian
Philippon, François
Roy, Karine
Molin, Franck
O'Hara, Gilles
Plourde, Benoit
Blier, Louis
Nault, Isabelle
Journal Article
United States
Pacing Clin Electrophysiol. 2020 Oct 6. doi: 10.1111/pace.14086.
PY  - 2020
SN  - 0147-8389
ST  - Findings of remote monitoring of implantable cardioverter defibrillators during the covid-19 pandemic
T2  - Pacing and clinical electrophysiology : PACE
TI  - Findings of remote monitoring of implantable cardioverter defibrillators during the covid-19 pandemic
ID  - 7791006
ER  - 

TY  - JOUR
AB  - OBJECTIVES: The objective of the paper was to assess real-life experience in the management of head and neck cancer (HNC) patients during the COVID-19 pandemic in radiotherapy departments and to evaluate the variability in terms of adherence to American Society of Radiation Oncology (ASTRO) and European Society for Radiotherapy and Oncology (ESTRO) recommendations. MATERIALS AND METHODS: In May 2020, an anonymous 30-question online survey, comparing acute phase of outbreak and pre-COVID-19 period, was conducted. Two sections exploited changes in general management of HNC patients and different HNC primary tumors, addressing specific statements from ASTRO ESTRO consensus statement as well. RESULTS: Eighty-eight questionnaires were included in the demographic/clinical workflow analysis, and 64 were analyzed for treatment management. Forty-eight percent of radiotherapy departments became part of oncologic hubs. First consultations reduced, and patients were addressed to other centers in 33.8 and 18.3% of cases, respectively. Telematic consultations were used in 50% of follow-up visits and 73.9% of multidisciplinary tumor board discussions. There were no practical changes in the management of patients affected by different primitive HNCs. Hypofractionation was not favored over conventional schedules. CONCLUSIONS: Compared to pre-COVID era, the clinical workflow was highly re-organized, whereas there were no consistent changes in RT indications and schedules.
AD  - Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Radiation Oncology, University Hospital, AOU of Modena, Modena, Italy.
Radiation Oncology Unit 2, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Radiation Oncology, Department of Oncology, University of Turin School of Medicine, Turin, Italy.
Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Department of Radiation Oncology, S. Croce and Carle Teaching Hospital, Cuneo, Italy.
Radiation Oncology, Policlinico San Martino IRCCS, Genoa, Italy.
Department of Radiation Oncology, ASST Spedali Civili of Brescia, Brescia, Italy.
Radiation Oncology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
Division of Radiation Oncology, Centro di Riferimento Oncologico di Aviano (CRO) IRCCS, Aviano, Italy.
Unit of Radiation Oncology, Ospedale del Mare, Naples, Italy.
Proton Therapy Unit, Department of Oncology, Azienda Provinciale per i Servizi Sanitari, APSS, 38123, Trento, Italy.
Radiation Oncology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Department of Radiation Oncology, "SS. Annunziata" Hospital, "G. D'Annunzio" University of Chieti, Chieti, Italy.
Radiation Oncology Unit S, Chiara University Hospital of Pisa, Pisa, Italy.
School of Medicine, University of Milan-Bicocca, Milan, Italy.
National Center of Oncological Hadrontherapy (Fondazione CNAO), Strada Campeggi, 53, 27100, Pavia, Italy.
Radiation Oncology Division, Oncology and Specialty Medicine Department, San Camillo-Forlanini Hospital, Rome, Italy.
National Center of Oncological Hadrontherapy (Fondazione CNAO), Strada Campeggi, 53, 27100, Pavia, Italy. ester.orlandi@cnao.it.
AN  - 33025304
AU  - De Felice, F.
AU  - D'Angelo, E.
AU  - Ingargiola, R.
AU  - Iacovelli, N. A.
AU  - Alterio, D.
AU  - Franco, P.
AU  - Bonomo, P.
AU  - Merlotti, A.
AU  - Bacigalupo, A.
AU  - Maddalo, M.
AU  - Di Rito, A.
AU  - Fanetti, G.
AU  - D'Onofrio, I.
AU  - Dionisi, F.
AU  - Miccich؈, F.
AU  - Trignani, M.
AU  - Musio, D.
AU  - Paiar, F.
AU  - Romanello, D. A.
AU  - Donato, V.
AU  - Orlandi, E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11547-020-01296-7
DP  - NLM
ET  - 2020/10/08
J2  - La Radiologia medica
KW  - Covid-19
Head and neck cancer
Radiotherapy
Survey
LA  - eng
N1  - 1826-6983
De Felice, Francesca
D'Angelo, Elisa
Ingargiola, Rossana
Iacovelli, Nicola Alessandro
Alterio, Daniela
Franco, Pierfrancesco
Bonomo, Pierluigi
Merlotti, Anna
Bacigalupo, Almalina
Maddalo, Marta
Di Rito, Alessia
Fanetti, Giuseppe
D'Onofrio, Ida
Dionisi, Francesco
Miccich؈, Francesco
Trignani, Marianna
Musio, Daniela
Paiar, Fabiola
Romanello, Domenico Attilio
Donato, Vittorio
Orlandi, Ester
Orcid: 0000-0001-6495-8574
Journal Article
Italy
Radiol Med. 2020 Oct 6. doi: 10.1007/s11547-020-01296-7.
PY  - 2020
SN  - 0033-8362
ST  - A snapshot on radiotherapy for head and neck cancer patients during the COVID-19 pandemic: a survey of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) head and neck working group
T2  - La Radiologia medica
TI  - A snapshot on radiotherapy for head and neck cancer patients during the COVID-19 pandemic: a survey of the Italian Association of Radiotherapy and Clinical Oncology (AIRO) head and neck working group
ID  - 7790715
ER  - 

TY  - JOUR
AB  - Disease-related skin lesions have been reported in 8-20% of COVID-19 patients. In the literature, cutaneous symptoms associated with the disease are generally emphasized. However, there are very few studies on the effect of this new SARS-CoV-2 virus entering our lives on dermatological diseases, and none of them have used the dermatological quality of life index (DLQI). In our study, we aimed to evaluate the difficulties faced by the patients who applied to the dermatology outpatient clinic during the pandemic period and the course of their diseases with the dermatological quality of life index. The study was carried out prospectively by including dermatology patients who will apply to the outpatient clinic in June-July 2020. 282 patients were evaluated in the study. DLQI was significantly lower in the group using regular emollients (p 0.001). When DLQI was compared between disease groups, it was found to be significantly different (p: 0.017). DLQI was found to worsen significantly compared to pre-pandemic studies. It was found that using moisturizer in this period helps to maintain the dermatological quality of life. This article is protected by copyright. All rights reserved.
AD  - Department of Dermatology, Necmettin Erbakan University Meram Medical Faculty, Konya, Turkey.
Clinic of Dermatology, Konya EreĞli State Hospital, Konya, Turkey.
AN  - 33021333
AU  - Daye, M.
AU  - Temiz, S. A.
AU  - Iş�\k, B.
AU  - Dursun, R.
AU  - Ataseven, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/dth.14368
DP  - NLM
ET  - 2020/10/07
J2  - Dermatologic therapy
KW  - Covid-19
Dermatological Quality Life Index
Inflammatory skin conditions
Pandemic
LA  - eng
N1  - 1529-8019
Daye, Munise
Orcid: 0000-0002-6614-1821
Temiz, Selami Aykut
Orcid: 0000-0003-4878-0045
Iş�\k, Begüm
Dursun, Recep
Ataseven, Arzu
Orcid: 0000-0001-5372-0712
Journal Article
United States
Dermatol Ther. 2020 Oct 6:e14368. doi: 10.1111/dth.14368.
PY  - 2020
SN  - 1396-0296
SP  - e14368
ST  - Evaluation of the Effect of COVID-19 Pandemic on Dermatological Diseases with Dermatological Quality Life Index
T2  - Dermatologic therapy
TI  - Evaluation of the Effect of COVID-19 Pandemic on Dermatological Diseases with Dermatological Quality Life Index
ID  - 7791038
ER  - 

TY  - JOUR
AB  - A new coronavirus strain has wreaked havoc on human lives so the WHO was declared as a pandemic since 20th March 2020 The Membrane glycoprotein MP spans the viral envelope and it has a highly conserved glycosylation sequence Aim: Our study goal was to find out the N-glycosylation, ligand binding sites, and antigenic variations between COVID-19 and other associated viruses Methods: We performed In silico methodologies for serial analysis at both an operational and result/output level is assessed and compared study factors Results: We detected high similarity in sequence alignment for &amp;gt; 89% between COVID-19 MP and other MP of CoVs Prediction of N-glycosylation and cytotoxic T-cell epitopes, we identified precisely sites between SARS-CoV-2 MP and Pangolin CoV MP 100% We also didn&#039;t obtain any similarity in ligand binding site residues between MP sequences Our study didn&#039;t reveal any similarity in CTL epitope predication between coronaviruses under study using the CTLPred server Conclusions: Our results exhibit that the membrane glycoprotein of SARS-CoV-2 is closely associated with predecessor SARS-CoVs specifically Pngolin CoV Prediction of novel CTL epitopes may substantial scopes for the expansion of a peptide-based vaccine for the inhibition virion assembly of SARS-CoV-2 Resumen Una nueva cepa de coronavirus est֙ causando estragos en la humanidad, por lo que la OMS declar�Q la situaci�Qn de pandemia el 20 de Marzo de 2020 La glicoprote�Tna de membrana MP atraviesa la envoltura viral, y tiene una secuencia de glicosilaci�Qn altamente conservada Objetivo: El objetivo de nuestro estudio fue averiguar la N-glicosilaci�Qn, los sitios de uni�Qn y las variaciones antigénicas entre COVID-19 y el resto de virus asociados Métodos: Realizamos metodolog�Tas in silico para an֙lisis de series, tanto a nivel operativo como de resultados, y valoramos y comparamos los factores de estudio Resultados: Detectamos una gran similitud en cuanto a la alineaci�Qn de secuencia para &amp;gt; 89% entre la MP de COVID-19 y otras MP de CoV Prediciendo la N-glicosilaci�Qn y los ep�Ttopos de las células T citot�Qxicas identificamos con precisi�Qn del 100% los sitios entre MP de SARS-CoV-2 y MP de CoV de Pangol�Tn No obtuvimos ninguna similitud en cuanto a los residuos del sitio de uni�Qn del ligando entre las secuencias de MP Nuestro estudio no revel�Q ninguna similitud en la predicci�Qn del ep�Ttope CTL entre los coronavirus estudiados, utilizando el servidor CTLPred Conclusiones: Nuestros resultados muestran que la glicoprote�Tna de membrana de SARS-CoV-2 est֙ estrechamente asociada a los SARS-CoV anteriores, espec�Tficamente CoV de Pangol�Tn La predicci�Qn de los nuevos ep�Ttopos CTL puede definir sustancialmente la expansi�Qn de una vacuna basada en péptidos para la inhibici�Qn del ensamblaje del viri�Qn de SARS-CoV-2
AU  - Dawood, Ali Adel
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Glicosilaci�Qn, sitios de uni�Qn de ligandos y variaciones antigénicas entre la glicoprote�Tna de membrana del COVID-19 y los coronavirus asociados
T2  - Vacunas
TI  - Glicosilaci�Qn, sitios de uni�Qn de ligandos y variaciones antigénicas entre la glicoprote�Tna de membrana del COVID-19 y los coronavirus asociados
UR  - https://doi.org/10.1016/j.vacun.2020.09.005
ID  - 7793042
ER  - 

TY  - JOUR
AB  - As the COVID 19 pandemic spread globally, the experiences of loss were compounded by personal loss Through this time of collective and individual grieving I set out to ?traverse? the experience and figure my ?perezhivanie? or lived emotional experience, through the materiality of mark making and entanglements with people, place, and art making Art making framed by the ?massive and microscopic? reflective prompts provided the opportunity for interventions into the medicalized and clinical world of hospitals and COVID 19, enacting beauty within a time of global, local, and personal grieving
AU  - Davis, Susan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Perezhivanie, Art, and Creative Traversal: A Method of Marking and Moving Through COVID and Grief
T2  - Qualitative Inquiry
TI  - Perezhivanie, Art, and Creative Traversal: A Method of Marking and Moving Through COVID and Grief
UR  - https://doi.org/10.1177/1077800420960158
ID  - 7792815
ER  - 

TY  - JOUR
AB  - Purpose The COVID-19 pandemic and related lockdown measures drastically changed health care and emergency services utilization This study evaluated trends in emergency department (ED) access for seizure-related reasons in the first 8 weeks of lockdown in Italy Methods All ED accesses of children (&amp;lt;14 years of age) at two university hospitals, in Turin and Rome, Italy, between January 6, 2020 and April 21, 2020, were examined and compared with the corresponding periods of 2019 Results During the COVID-19 lockdown period (February 23-April 21, 2020), there was a 72% decrease in all pediatric ED accesses over the corresponding 2019 period (n�?�?,395 vs n�?�?2,128), with a 38% decrease in seizure-related accesses (n�?�?1 vs n�?�?6) The observed decrease of seizure-related ED accesses was not accompanied by significant changes in age, sex, type of seizure, or hospitalization rate after the ED visit Conclusion The COVID-19 lockdown was accompanied by a sudden decrease in seizure-related hospital emergency visits School closure, social distancing, reduced risk of infection, and increased parental supervision are some of the factors that might have contributed to the finding
AU  - Davico, Chiara
AU  - Marcotulli, Daniele
AU  - Lux, Caterina
AU  - Calderoni, Dario
AU  - Terrinoni, Arianna
AU  - Di Santo, Federica
AU  - Ricci, Federica
AU  - Vittorini, Roberta
AU  - Amianto, Federico
AU  - Urbino, Antonio
AU  - Ferrara, Mauro
AU  - Vitiello, Benedetto
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Where have the children with epilepsy gone? An observational study of seizure-related accesses to emergency department at the time of COVID-19
T2  - Seizure
TI  - Where have the children with epilepsy gone? An observational study of seizure-related accesses to emergency department at the time of COVID-19
UR  - https://doi.org/10.1016/j.seizure.2020.09.025
ID  - 7793050
ER  - 

TY  - JOUR
AD  - CHU de Caen, Department of Medical Intensive Care, 14000 Caen, France. Electronic address: daubin-c@chu-caen.fr.
CHU de Caen, Department of Pulmonology & Thoracic Oncology, 14000 Caen, France.
CHU de Caen, Department of Virology, 14000 Caen, France.
CHU de Grenoble Alpes, Department of Medical Intensive Care, F-38000 Grenoble, France.
AN  - 33022292
AU  - Daubin, C.
AU  - Justet, A.
AU  - Vabret, A.
AU  - Bergot, E.
AU  - Terzi, N.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.medmal.2020.09.015
DP  - NLM
ET  - 2020/10/07
J2  - Medecine et maladies infectieuses
LA  - eng
N1  - 1769-6690
Daubin, Cédric
Justet, Aurélien
Vabret, Astrid
Bergot, Emmanuel
Terzi, Nicolas
Letter
France
Med Mal Infect. 2020 Oct 3:S0399-077X(20)30713-7. doi: 10.1016/j.medmal.2020.09.015.
PY  - 2020
SN  - 0399-077x
ST  - Is a COPD patient protected against SARS-CoV-2 virus?
T2  - Medecine et maladies infectieuses
TI  - Is a COPD patient protected against SARS-CoV-2 virus?
ID  - 7790969
ER  - 

TY  - JOUR
AB  - The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand?analyte or antibody?antigen interactions taking place on the sensor surface The coronavirus disease (COVID-19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID-19 SARS-CoV-2 spike protein is presented Simulation results for different prismatic configurations for the basic Kretschmann layout are presented It is found that a BK7 glass prism-based SPR sensor has an incremental sensitivity of 111 11 deg RIU?1 Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth
AU  - Das, Chandreyee Manas
AU  - Guo, Yan
AU  - Yang, Guang
AU  - Kang, Lixing
AU  - Xu, Gaixia
AU  - Ho, Ho-Pui
AU  - Yong, Ken-Tye
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID-19 SARS-CoV-2 Spike Protein
T2  - Advanced Theory and Simulations
TI  - Gold Nanorod Assisted Enhanced Plasmonic Detection Scheme of COVID-19 SARS-CoV-2 Spike Protein
UR  - https://doi.org/10.1002/adts.202000185
ID  - 7793320
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has currently led to a global pandemic with millions of confirmed and increasing cases around the world The novel SARS-CoV-2 not only affects the lungs causing severe acute respiratory dysfunction but also leads to significant dysfunction in multiple organs and physiological systems including the cardiovascular system A plethora of studies have shown the viral infection triggers an exaggerated immune response, hypercoagulation and oxidative stress, which contribute significantly to poor cardiovascular outcomes observed in COVID-19 patients To date, there are no approved vaccines or therapies for COVID-19 Accordingly, cardiovascular protective and supportive therapies are urgent and necessary to the overall prognosis of COVID-19 patients Accumulating literature has demonstrated the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) toward the cardiovascular system, which include ameliorating uncontrolled inflammatory reactions, reduced oxidative stress and mitigating coagulopathy Moreover, it has been demonstrated the n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are precursors to a group of potent bioactive lipid mediators, generated endogenously, which mediate many of the beneficial effects attributed to their parent compounds Considering the favorable safety profile for n-3 PUFAs and their metabolites, it is reasonable to consider n-3 PUFAs as potential adjuvant therapies for the clinical management of COVID-19 patients In this article, we provide an overview of the pathogenesis of cardiovascular complications secondary to COVID-19 and focus on the mechanisms that may contribute to the likely benefits of n-3 PUFAs and their metabolites
AU  - Darwesh, Ahmed M.
AU  - Bassiouni, Wesam
AU  - Sosnowski, Deanna K.
AU  - Seubert, John M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?
T2  - Pharmacology & Therapeutics
TI  - Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?
UR  - https://doi.org/10.1016/j.pharmthera.2020.107703
ID  - 7793079
ER  - 

TY  - JOUR
AU  - Danchin, M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Vaccination during the COVID-19 pandemic
T2  - Australian Family Physician
TI  - Vaccination during the COVID-19 pandemic
UR  - https://pesquisa.bvsalud.org/portal/resource/en/mdl-33015653
ID  - 7793366
ER  - 

TY  - JOUR
AB  - COVID-19 spans and wide range of symptoms, sometimes with profound immune system involvement. How immune cell subsets change during the disease course and with disease severity needs further study. While myeloid cells have been shown to initiate and maintain responses to pneumonia and lung inflammation, often playing a role in resolution, their involvement with COVID-19 remains unknown. In this issue of the JCI, S֙nchez-Cerrillo and Pedro-Landete et al. investigated dendritic cells and monocytes from blood and bronchial secretions of patients with varying COVID-19 severity and with healthy controls. The authors conclude that circulating monocytes and DCs migrate from the blood into the inflamed lungs. While sampling differences in sex, collection timing, bacteria/fungal infection, and corticosteroid treatment limit interpretation, we believe that reprograming monocyte or macrophages by targeting immunometabolism, epigenetics, or the cytokine milieu holds promise in resolving lung-inflammation associated with COVID-19.
AD  - Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, United States of America.
Department of Anesthesiology and Critical Care Medicine, Division of Allerg, Johns Hopkins University School of Medicine, Baltimore, United States of America.
AN  - 33021506
AU  - D'Alessio, F. R.
AU  - Heller, N. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1172/jci143361
DP  - NLM
ET  - 2020/10/07
J2  - The Journal of clinical investigation
LA  - eng
N1  - 1558-8238
D'Alessio, Franco R
Heller, Nicola M
Journal Article
United States
J Clin Invest. 2020 Oct 6:143361. doi: 10.1172/JCI143361.
PY  - 2020
SN  - 0021-9738
ST  - COVID-19 and myeloid cells: complex interplay correlates with lung severity
T2  - Journal of clinical investigation
TI  - COVID-19 and myeloid cells: complex interplay correlates with lung severity
ID  - 7791026
ER  - 

TY  - JOUR
AU  - Dabisch, Paul
AU  - Schuit, Michael
AU  - Herzog, Artemas
AU  - Beck, Katie
AU  - Wood, Stewart
AU  - Krause, Melissa
AU  - Miller, David
AU  - Weaver, Wade
AU  - Freeburger, Denise
AU  - Hooper, Idris
AU  - Green, Brian
AU  - Williams, Gregory
AU  - Holland, Brian
AU  - Bohannon, Jordan
AU  - Wahl, Victoria
AU  - Yolitz, Jason
AU  - Hevey, Michael
AU  - Ratnesar-Shumate, Shanna
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Influence of Temperature, Humidity, and Simulated Sunlight on the Infectivity of SARS-CoV-2 in Aerosols
T2  - Aerosol Science and Technology
TI  - The Influence of Temperature, Humidity, and Simulated Sunlight on the Infectivity of SARS-CoV-2 in Aerosols
UR  - https://doi.org/10.1080/02786826.2020.1829536
ID  - 7792980
ER  - 

TY  - JOUR
AB  - Quinolines are nitrogen heterocyclic compounds ubiquitous in nature and largely used as a structural component of dyes, solvent for resins, terpenes as well as during the production of several other chemical stuffs, including pesticides. Quinolines, such as quinine and chloroquine, exhibit various pharmacological properties, acting as antimalarial drugs, antiparasitic, antibacterial, antiviral, antifungal, and anticancer agents, besides being in clinical use for autoimmune diseases. Presently, a brief review is present regarding the biological effect and clinical use of quinolines and derivatives upon two trypanosomatids agents of important neglected tropical diseases; Trypanosoma cruzi, Trypanosoma brucei spp and Leishmania spp, which trigger Chagas disease, sleeping sickness and leishmaniasis, respectively, also extending to a glance update of their potential application towards other microbes relevant for emerging illness caused by fungi, bacteria and virus, including the pandemic Covid-19.
AD  - Laborat�Qrio de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro. Brazil.
AN  - 33023440
AU  - da Gama, A. N. S.
AU  - de Nazaré Correia Soeiro, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.2174/1381612826666201006125644
DP  - NLM
ET  - 2020/10/08
J2  - Current pharmaceutical design
KW  - Covid-19.
Leishmania
Trypanosoma cruzi
chloroquine
drug discovery
quinolines
repurposing drugs
LA  - eng
N1  - 1873-4286
da Gama, Aline Nefertiti Silva
de Nazaré Correia Soeiro, Maria
Journal Article
United Arab Emirates
Curr Pharm Des. 2020 Oct 6. doi: 10.2174/1381612826666201006125644.
PY  - 2020
SN  - 1381-6128
ST  - Quinoline-based Compounds as Key Candidates to Tackle Drug Discovery Programs of Microbicidal Agents
T2  - Current pharmaceutical design
TI  - Quinoline-based Compounds as Key Candidates to Tackle Drug Discovery Programs of Microbicidal Agents
ID  - 7790910
ER  - 

TY  - JOUR
AU  - Czegledy, Peter
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - CANADIAN LAND-BASED GAMBLING IN THE TIME OF COVID-19
T2  - Gaming Law Review
TI  - CANADIAN LAND-BASED GAMBLING IN THE TIME OF COVID-19
UR  - https://doi.org/10.1089/glr2.2020.24811
ID  - 7792936
ER  - 

TY  - JOUR
AB  - At the end of 2019, a new disease -COVID-19-was identified, and a few months later, the World Health Organization announced a pandemic. It is now known that SARS-CoV-2 is highly contagious and most confirmed infections are mild to moderate. The situation is particularly difficult for dentists due to the high risk of virus transmission in the dental surgery. Complications including, but not limited to, problems with the respiratory and cardiovascular systems have been reported in patients with SARS-CoV-2. Several changes in the coagulation system, such as lower platelet numbers or increased prothrombin time, as well as increased D-dimer and fibrinogen, were observed. This review is intended to systematize the knowledge on the treatment of patients with congenital bleeding disorders (CBD) during the SARS-CoV-2 pandemic. Extensive literature research was conducted into COVID-19 and the general medical and dental treatment of patients with CBD. Case studies, research results and recommendations of international societies were used in the study. The results of this research are presented in the form of recommendations for the treatment of patients with coagulopathies. It should be remembered that the impact of COVID-19 on the health condition of patients with CBD is unknown to date.
AD  - Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, Bukowska 70, 60-812 Poznan, Poland.
Department of Hematology and Bone Marrow Transplantation, Poznan University of Medical Sciences, Szamarzewskiego 84, 60-569 Poznan, Poland.
AN  - 33023050
AU  - Czajkowska, S.
AU  - Rupa-Matysek, J.
AU  - Gil, L.
AU  - Surdacka, A.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/ijerph17197245
DP  - NLM
ET  - 2020/10/08
IS  - 19
J2  - International journal of environmental research and public health
KW  - Covid-19
blood coagulation disorders
cardiovascular system
dentists
pandemics
severe acute respiratory syndrome coronavirus 2
LA  - eng
N1  - 1660-4601
Czajkowska, Sylwia
Rupa-Matysek, Joanna
Gil, Lidia
Surdacka, Anna
Journal Article
Review
Switzerland
Int J Environ Res Public Health. 2020 Oct 3;17(19):E7245. doi: 10.3390/ijerph17197245.
PY  - 2020
SN  - 1660-4601
ST  - Practical Recommendations for Treatment of Dental Patients with Congenital Bleeding Disorders during the Covid-19 Pandemic: A Narrative Review
T2  - International journal of environmental research and public health
TI  - Practical Recommendations for Treatment of Dental Patients with Congenital Bleeding Disorders during the Covid-19 Pandemic: A Narrative Review
VL  - 17
ID  - 7790928
ER  - 

TY  - JOUR
AB  - Replication-incompetent adenoviral vectors have been under investigation as a platform to carry a variety of transgenes, and express various antigens as a basis for preventive or therapeutic vaccine development A replication incompetent adenoviral vector based on human adenovirus type 26 (Ad26) has been evaluated in several clinical trials The Brighton Collaboration Viral Vector Vaccines Safety Working Group (V3SWG) was formed to evaluate the safety and features of recombinant viral vector vaccines This paper reviews the biological features of the Ad26 vectors, including tabulation of safety and risk assessment characteristics of Ad26 vector-based vaccines Substantial information on immunogenicity, clinical safety, biological characteristics and manufacturing are reported In the Ad26 vector, deletion of the E1 gene, rendering the vector replication incompetent and providing space for transgene insertion, is combined with additional genetic engineering for vaccine manufacturability and transgene expression optimization These vaccines are manufactured using the E1-complementing PER C6�] cell line, a continuous, human cell-line that can be cultured in serum-free medium in a suspension to high cell densities, providing an effective and flexible system for high-yield manufacturing Ad26 vector vaccines have favorable thermostability profiles, compatible with vaccine supply chains Safety data are compiled in the Ad26 vaccine safety database version 4 0, with unblinded data from 23 ongoing and completed clinical studies for a total of 3912 participants in Ebola, HIV, Malaria, RSV and Filovirus Ad26-based vaccine programs Overall, all Ad26-based vaccines have been well tolerated, with no significant safety issues identified from the available data in the current Ad26 vaccine safety database Evaluation of Ad26-based vaccines to further characterize the safety profile is continuing, with more than 90,000 participants vaccinated as of 1st July 2020 (cut-off date) Extensive evaluation of immunogenicity in humans shows strong and durable humoral and cellular immune responses Clinical trials have not shown meaningful impact of pre-existing immunity to Ad26 on vaccine immunogenicity, even in the presence of Ad26 neutralizing antibody titers or Ad26-targeting T cell responses at baseline The first vaccine, against Ebola virus, that makes use of the Ad26 vector, received marketing authorization from EC on 1st July 2020, as part of the Ad26 ZEBOV, MVA BN Filo vaccine regimen New developments based on the Ad26 vector are underway, including a COVID-19 vaccine, which is currently in clinical evaluation
AU  - Custers, Jerome
AU  - Kim, Denny
AU  - Leyssen, Maarten
AU  - Gurwith, Marc
AU  - Tomaka, Frank
AU  - Robertson, James
AU  - Heijnen, Esther
AU  - Condit, Richard
AU  - Shukarev, Georgi
AU  - Heerwegh, Dirk
AU  - van Heesbeen, Roy
AU  - Schuitemaker, Hanneke
AU  - Douoguih, Macaya
AU  - Evans, Eric
AU  - Smith, Emily R.
AU  - Chen, Robert T.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Vaccines based on replication incompetent Ad26 viral vectors: standardized template with key considerations for a risk/benefit assessment
T2  - Vaccine
TI  - Vaccines based on replication incompetent Ad26 viral vectors: standardized template with key considerations for a risk/benefit assessment
UR  - https://doi.org/10.1016/j.vaccine.2020.09.018
ID  - 7793044
ER  - 

TY  - JOUR
AB  - Airborne transmission of SARS-CoV-2 through virus-containing aerosol particles has been established as an important pathway for Covid-19 infection. Suitable measures to prevent such infections are imperative, especially in situations when a high number of persons convene in closed rooms. Here we tested the efficiency and practicability of operating four air purifiers equipped with HEPA filters in a high school classroom while regular classes were taking place. We monitored the aerosol number concentration for particles &amp;gt; 3 nm at two locations in the room, the aerosol size distribution in the range from 10 nm to 10 μm, PM10 and CO2 concentration. For comparison, we performed similar measurements in a neighboring classroom without purifiers. In times when classes were conducted with windows and door closed, the aerosol concentration was reduced by more than 90 % within less than 30 minutes when running the purifiers (air exchange rate 5.5 h-1). The reduction was homogeneous throughout the room and for all particle sizes. The measurements are supplemented by a calculation estimating the maximum concentration levels of virus-containing aerosol from a highly contagious person speaking in a closed room with and without air purifiers. Measurements and calculation demonstrate that air purifiers represent a well suited measure to reduce the risks of airborne transmission of SARS-CoV-2 substantially. Staying for two hours in a closed room with a super infective person, we estimate that the inhaled dose is reduced by a factor of six when using air purifiers with a total air exchange rate of 5.7 h-1.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe project was conducted with internal financial support only. No funding was received from third parties for any aspect of the submitted work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:n.a.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe original data is available from the corresponding author upon request.
AU  - Curtius, Joachim
AU  - Granzin, Manuel
AU  - Schrod, Jann
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205633
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205633
ST  - Testing mobile air purifiers in a school classroom: Reducing the airborne transmission risk for SARS-CoV-2 (preprint)
T2  - medRxiv
TI  - Testing mobile air purifiers in a school classroom: Reducing the airborne transmission risk for SARS-CoV-2 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.02.20205633.abstract
ID  - 7794774
ER  - 

TY  - JOUR
AB  - A nickel-catalyzed asymmetric reductive hydroarylation of vinyl amides to produce enantioenriched ��-arylbenzamides is reported The use of a chiral bisimidazoline (BIm) ligand, in combination with diethoxymethylsilane and aryl halides, enables regioselective introduction of aryl groups to the internal position of the olefin, forging a new stereogenic center �� to the N atom The use of neutral reagents and mild reaction conditions provides simple access to pharmacologically relevant motifs present in anticancer, SARS-CoV PLpro inhibitors and KCNQ channel openers
AU  - Cuesta-Galisteo, S.
AU  - Schörgenhumer, J.
AU  - Wei, X.
AU  - Merino, E.
AU  - Nevado, C.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Nickel-Catalyzed Asymmetric Synthesis of ��-Arylbenzamides
T2  - Angew Chem Int Ed Engl
TI  - Nickel-Catalyzed Asymmetric Synthesis of ��-Arylbenzamides
UR  - https://doi.org/10.1002/anie.202011342
ID  - 7793319
ER  - 

TY  - JOUR
AU  - Csernatoni, Raluca
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - New states of emergency: normalizing techno-surveillance in the time of COVID-19
T2  - Global Affairs
TI  - New states of emergency: normalizing techno-surveillance in the time of COVID-19
UR  - https://doi.org/10.1080/23340460.2020.1825108
ID  - 7792940
ER  - 

TY  - JOUR
AU  - Crimi, Claudia
AU  - Carlucci, Annalisa
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Challenges for the female health-care workers during the COVID-19 pandemic: the need for protection beyond the mask
T2  - Pulmonology
TI  - Challenges for the female health-care workers during the COVID-19 pandemic: the need for protection beyond the mask
UR  - https://doi.org/10.1016/j.pulmoe.2020.09.004
ID  - 7793073
ER  - 

TY  - JOUR
AU  - Crews, J. R.
AU  - Barrett, N.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Addressing Racism and Disparities in Oncology
T2  - Oncology Issues
TI  - Addressing Racism and Disparities in Oncology
UR  - https://doi.org/10.1080/10463356.2020.1809865
ID  - 7792970
ER  - 

TY  - JOUR
AB  - Libraries increasingly seek to support the mental health and well-being of students This study reports on the results of a survey examining the range of such support activities offered by UK academic libraries prior to and during the COVID-19 pandemic Prior to the pandemic libraries&#039; emphasis was on new library specific services such as a fiction collection, a type of initiative taken to proactively align with institutional policy During the pandemic focus shifted somewhat to addressing the anxiety related to finding e-resources Drawing on the survey data a holistic model of library support for student mental health and well-being is developed, capturing its eight different aspects: inherent library value, library services impact, well-being as a library service, detection, hosting, signposting, library as a good partner and library staff well-being This represents a framework through which to examine how an academic library can support student mental health and well-being, and complements the “whole university�?approach being increasingly adopted in the UK
AU  - Cox, Andrew
AU  - Brewster, Liz
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Library support for student mental health and well-being in the UK: Before and during the COVID-19 pandemic
T2  - Journal of Academic Librarianship
TI  - Library support for student mental health and well-being in the UK: Before and during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.acalib.2020.102256
ID  - 7793262
ER  - 

TY  - JOUR
AB  - BACKGROUND: Among hypertensive patients, the association between treatment with angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) and the clinical severity of Covid-19, remains uncertain. AIMS: To determine whether hypertensive patients hospitalized with Covid-19 are at risk of worse outcomes if on treatment with ACEIs or ARBs compared to other anti-hypertensive medications. METHODS: This is a retrospective study conducted at a single academic medical center [Fondazione Policlinico A.Gemelli IRCCS, Rome, Italy] from March 1(st) to 31 (st) , 2020. We compared patients on treatment with an ACEIs/ARBs (ACEIs/ARBs group) to patients receiving other anti-hypertensive medications (No-ACEIs/ARBs group). The endpoints of the study were the all-cause in-hospital death and the combination of in-hospital death or need for ICU admission. RESULTS: The sample included 166 Covid-19 patients; median age was 74 years and 109 were men (66%). Overall, 111 patients (67%) were taking an ACEIs or ARBs. Twenty-nine patients (17%) died during hospital stay, and 51 (31%) met the combined endpoint. After adjustment for comorbidities, age and degree of severity at the presentation, ACEIs or ARBs treatment was an independent predictor neither of in-hospital death nor of the combination of in-hospital death/need for ICU. No differences were documented between treatment with ACEIs compared to ARBs. CONCLUSIONS: Among hypertensive patients hospitalized for Covid-19, treatment with ACEIs or ARBs is not associated with an increased risk of in-hospital death. This article is protected by copyright. All rights reserved.
AD  - Emergency Department, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Department of Internal Medicine, Fondazione Policlinico Universitario A.Gemelli IRCCS, Rome, Italy.
Department of Anesthesiology and Intensive Care Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Department of Internal Medicine and Gastroenterology, Fondazione Policlinico Universitario A. Gemelli, Rome, Italy.
Università Cattolica del Sacro Cuore, Rome, Italy.
AN  - 33022124
AU  - Covino, M.
AU  - De Matteis, G.
AU  - Burzo, M. L.
AU  - Santoro, M.
AU  - Fuorlo, M.
AU  - Sabia, L.
AU  - Sandroni, C.
AU  - Gasbarrini, A. Prof
AU  - Franceschi, F. Prof
AU  - Gambassi, G. Prof
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/imj.15078
DP  - NLM
ET  - 2020/10/07
J2  - Internal medicine journal
KW  - Covid-19
SARS-CoV-2
angiotensin II receptor blockers.
angiotensin-converting enzyme inhibitors
hypertension
LA  - eng
N1  - 1445-5994
Covino, Marcello
De Matteis, Giuseppe
Orcid: 0000-0003-2982-3951
Burzo, Maria Livia
Santoro, Michele
Fuorlo, Mariella
Sabia, Luca
Sandroni, Claudio
Gasbarrini, Antonio Prof
Franceschi, Francesco Prof
Gambassi, Giovanni Prof
GEMELLI AGAINST COVID-19 Group
Journal Article
Australia
Intern Med J. 2020 Oct 6. doi: 10.1111/imj.15078.
PY  - 2020
SN  - 1444-0903
ST  - Angiotensin-Converting Enzyme Inhibitors Or Angiotensin Ii Receptor Blockers And Prognosis Of Hypertensive Patients Hospitalized With Covid-19
T2  - Internal medicine journal
TI  - Angiotensin-Converting Enzyme Inhibitors Or Angiotensin Ii Receptor Blockers And Prognosis Of Hypertensive Patients Hospitalized With Covid-19
ID  - 7790979
ER  - 

TY  - JOUR
AB  - The response to the COVID-19 crisis has created direct pressure on health care providers to deliver virtual care, and has created the opportunity to develop innovations in remote treatment for people with substance use disorders Remote treatments provide an intervention delivery framework that capitalizes on technological innovations in remote monitoring of behaviors and can efficiently use information collected from people and their environment to provide personalized treatments as needed Interventions informed by behavioral economic theories can help to harness the largely untapped potential of virtual care in substance use treatment Behavioral economic treatments, such as contingency management, the substance-free activity session, and episodic future thinking, are positioned to leverage remote monitoring of substance use and to use personalized medicine frameworks to deliver remote interventions in the COVID-19 era and beyond
AU  - Coughlin, Lara N.
AU  - Bonar, Erin E.
AU  - Bickel, Warren K.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Considerations for remote delivery of behavioral economic interventions for substance use disorder during COVID-19 and beyond
T2  - Journal of Substance Abuse Treatment
TI  - Considerations for remote delivery of behavioral economic interventions for substance use disorder during COVID-19 and beyond
UR  - https://doi.org/10.1016/j.jsat.2020.108150
ID  - 7793117
ER  - 

TY  - JOUR
AB  - Within Neurotology, special draping systems have been devised for mastoid surgery recognizing that drilling of middle ear mucosa is an aerosol generating medical procedure (AGMP) which can place surgical teams at risk of COVID-19 infection. We provide a thorough description of a barrier system utilized in our practice, along with work completed by our group to better quantify its effectiveness. Utilization of a barrier system can provide near complete bone dust and droplet containment within the surgical field and prevent contamination of other healthcare workers. As this is an early system, further adaptations and national collaborations are required to ultimately arrive at a system that seamlessly integrates into the surgical suite. While these barrier systems are new, they are timely as we face a pandemic, and can play a crucial role in safely resuming surgery.
AD  - Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada. justin.cottrell@mail.utoronto.ca.
Department of Otolaryngology - Head & Neck Surgery, University of Toronto, St. George Campus, David Naylor Building, 6 Queen's Park Crescent West, Suite 120, Toronto, ON, M5S 3H2, Canada. justin.cottrell@mail.utoronto.ca.
Sunnybrook Health Science Centre, University of Toronto, Toronto, Ontario, Canada.
Department of Otolaryngology - Head & Neck Surgery, University of Toronto, St. George Campus, David Naylor Building, 6 Queen's Park Crescent West, Suite 120, Toronto, ON, M5S 3H2, Canada.
AN  - 33023663
AU  - Cottrell, J.
AU  - Lui, J.
AU  - Le, T.
AU  - Chen, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s40463-020-00471-0
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
KW  - Agmp
Barrier system
Covid-19
Healthcare safety
Mastoidectomy
Neurotology
LA  - eng
N1  - 1916-0216
Cottrell, Justin
Orcid: 0000-0002-8434-5262
Lui, Justin
Le, Trung
Chen, Joseph
Journal Article
England
J Otolaryngol Head Neck Surg. 2020 Oct 6;49(1):71. doi: 10.1186/s40463-020-00471-0.
PY  - 2020
SN  - 1916-0208
SP  - 71
ST  - An operative barrier system for skull base and mastoid surgery: creating a safe operative theatre in the era of COVID-19
T2  - Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale
TI  - An operative barrier system for skull base and mastoid surgery: creating a safe operative theatre in the era of COVID-19
VL  - 49
ID  - 7790892
ER  - 

TY  - JOUR
AB  - The absence of a specific treatment for SARS-CoV-2 infection led to an intense global effort in order to find new therapeutic interventions and improve patient outcomes. One important feature of COVID-19 pathophysiology is the activation of immune cells, with consequent massive production and release of inflammatory mediators that may cause impairment of several organ functions, including the brain. In addition to its classical role as a neurotransmitter, serotonin (5-hydroxytryptamine, 5-HT) has immunomodulatory properties, downregulating the inflammatory response by central and peripheral mechanisms. In this review, we describe the roles of 5-HT in the regulation of systemic inflammation and the potential benefits of the use of specific serotonin reuptake inhibitors as a coadjutant therapy to attenuate neurological complications of COVID-19.
AD  - Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-904, Brazil.
Department of Basic and Oral Biology, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, 14040-904, Brazil. Electronic address: branco@forp.usp.br.
AN  - 33022271
AU  - Costa, L. H. A.
AU  - Santos, B. M.
AU  - Branco, L. G. S.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.ejphar.2020.173629
DP  - NLM
ET  - 2020/10/07
J2  - European journal of pharmacology
KW  - Cytokines
Inflammation
SARS-CoV-2
Serotonin
LA  - eng
N1  - 1879-0712
Costa, Luis H A
Santos, Bruna M
Branco, Luiz G S
Journal Article
Netherlands
Eur J Pharmacol. 2020 Oct 3:173629. doi: 10.1016/j.ejphar.2020.173629.
PY  - 2020
SN  - 0014-2999
SP  - 173629
ST  - Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?
T2  - European journal of pharmacology
TI  - Can selective serotonin reuptake inhibitors have a neuroprotective effect during COVID-19?
ID  - 7790973
ER  - 

TY  - JOUR
AB  - Zusammenfassung Hintergrund Etwa 35 000 Menschen in Deutschland erlitten im Jahr 2019 eine Aphasie infolge eines Schlaganfalls Eine der häufigsten Manifestationen einer Aphasie stellen Wortfindungsstörungen dar In Zeiten der COVID-19-Pandemie ermöglicht die befristete Zulassung der Videotherapie die Aufrechterhaltung einer sprachtherapeutischen Behandlung Daraus ergibt sich die Notwendigkeit zu untersuchen, welche Wirksamkeit eine Screen-to-Screen-Therapie über ein Videokonferenzsystem gegenüber einer herkömmlichen Face-to-Face-Therapie bei erwachsenen Aphasiepatient*innen auf die Benennleistungen hat Methode Im Rahmen eines Scoping Reviews wurde eine Literaturrecherche in den Datenbanken Cochrane, Pubmed und Web of Science für den Zeitraum Februar 2010 bis 2020 durchgeführt Eingeschlossen wurden deutsch- und englischsprachige Studien, welche die Wirksamkeit einer klassischen Face-to-Face-Therapie mit einer Screen-to-Screen-Therapie bei Erwachsenen mit Aphasie miteinander vergleichen und als einen Outcome die Benennleistung erhoben haben Die Auswahl der Studien erfolgte mithilfe des PRISMA-Flussdiagramms Ergebnisse Insgesamt konnten fünf Studien gefunden werden Sowohl die Face-to-Face-Therapie als auch die Screen-to-Screen-Therapie zeigten in einer italienischen Crossover-Studie, einer kanadischen randomisierten Studie und einer in Großbritannien durchgeführten quasi-randomisierten Studie signifikante Verbesserungen der Benennleistungen Keine Verbesserungen wurden für beide Interventionsformen in einer israelischen Crossover-Studie festgestellt In einer deutschen Vergleichsstudie wurden für die Face-to-Face-Therapie signifikante Verbesserungen der Benennleistungen gemessen, deren Ergebnis sich jedoch nicht signifikant von der Interventionsgruppe der Screen-to-Screen-Therapie unterschied Diskussion In allen eingeschlossenen Studien hatten die Screen-to-Screen-Therapie und die Face-to-Face-Therapie eine vergleichbare Wirksamkeit auf die Benennleistungen Die Ergebnisse sprechen für die Realisierbarkeit einer Screen-to-Screen-Therapie unter Alltagsbedingungen Möglicherweise ist diese Therapieform jedoch nicht immer umsetzbar Barrieren für eine Screen-to-Screen-Therapie können die Bedienung von Technologien sowie Einschränkungen des Gesichtsfeldes infolge eines Neglects sein Limitationen des Scoping Reviews sind, dass lediglich die Benennleistungen als Outcome betrachtet wurden sowie die geringe Anzahl der eingeschlossenen Studien Schlussfolgerung Im Hinblick auf die Tatsache, dass eine Screen-to-Screen-Therapie während der COVID-19-Pandemie für viele Patient*innen die einzige Möglichkeit einer sprachtherapeutischen Behandlung darstellt, ist es positiv zu werten, dass die Screen-to-Screen-Therapie genauso wirksam ist wie die Face-to-Face-Therapie Die Screen-to-Screen-Therapie kann einen erweiterten Zugang zu der Gesundheitsversorgung sowie fachlicher Expertise im Gesundheitswesen ermöglichen Die Aufrechterhaltung der sprachtherapeutischen Versorgung während der COVID-19-Pandemie kann dadurch weitestgehend gesichert werden Es bedarf weiterer Forschung zu evidenzbasierten Behandlungsmethoden und anwenderorientierten Apps für die Videotherapie Introduction About 35,000 people in Germany suffered from stroke-related aphasia in 2019 One of the most frequent manifestations of aphasia are word finding disorders In times of the COVID-19 pandemic, the temporary approval of video therapy enables the maintenance of speech therapy treatment This leads to the necessity to investigate the effectiveness of screen-to-screen-therapy via a video conferencing system compared to conventional face-to-face-therapy of adult aphasia patients Methods For this scoping review, a literature search in the databases Cochrane, Pubmed and Web of Science was conducted for the period February 2010 to 2020 We included German- and English-language studies comparing the effectiveness of a classic face-to-face-therapy with a screen-to-screen-therapy of adults with aphasia The studies were selected using the RISMA flowchart Results A total of five studies were identified Both face-to-face-therapy and screen-to-screen therapy showed significant improvements in naming performance in an Italian crossover study, a Canadian randomized study and a quasi-randomized study conducted in the UK No improvements were found for both forms of intervention in an Israeli crossover study In a German comparative study, significant improvements in naming performance were found for face-to-face therapy, but the results did not differ significantly from the screen-to-screen-therapy intervention group Discussion In all included studies, screen-to-screen-therapy and face-to-face-therapy had a comparable effectiveness on naming performance The results demonstrate the feasibility of a screen-to-screen-therapy under everyday conditions However, it is possible that this form of therapy cannot always be implemented Barriers to screen-to-screen-therapy can be the use of technologies and restrictions in the visual field due to a neglect One limitation of the scoping review was that only the naming performance was considered as an outcome, another was the small number of studies included Conclusion For many patients screen-to-screen-therapy is currently the only possibility to receive speech therapy treatment Therefore it is a positive aspect that screen-to-screen-therapy is as effective as face-to-face-therapy Screen-to-screen-therapy can provide expanded access to health care and professional expertise in health services In this way, speech therapy care during the COVID-19 pandemic can be largely maintained Further research is needed on evidence-based treatment methods and user-oriented apps for video therapy
AU  - Cordes, Lara
AU  - Loukanova, Svetla
AU  - Forstner, Johanna
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Scoping Review über die Wirksamkeit einer Screen-to-Screen-Therapie im Vergleich zu einer Face-to-Face-Therapie bei Patient*innen mit Aphasie auf die Benennleistungen
T2  - Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen
TI  - Scoping Review über die Wirksamkeit einer Screen-to-Screen-Therapie im Vergleich zu einer Face-to-Face-Therapie bei Patient*innen mit Aphasie auf die Benennleistungen
UR  - https://doi.org/10.1016/j.zefq.2020.08.002
ID  - 7793033
ER  - 

TY  - JOUR
AB  - Summary: Background: Chilblains ('COVID toes') are being seen with increasing frequency in children and young adults during the COVID�?9 pandemic. Detailed histopathological descriptions of COVID�?9 chilblains have not been reported, and causality of SARS‐CoV�? has not yet been established. Objectives: To describe the histopathological features of COVID�?9 chilblains and to explore the presence of SARS‐CoV�? in the tissue. Methods: We examined skin biopsies from seven paediatric patients presenting with chilblains during the COVID�?9 pandemic. Immunohistochemistry for SARS‐CoV�? was performed in all cases and electron microscopy in one. Results: Histopathology showed variable degrees of lymphocytic vasculitis ranging from endothelial swelling and endotheliitis to fibrinoid necrosis and thrombosis. Purpura, superficial and deep perivascular lymphocytic inflammation with perieccrine accentuation, oedema, and mild vacuolar interface damage were also seen. SARS‐CoV�? immunohistochemistry was positive in endothelial cells and epithelial cells of eccrine glands. Coronavirus particles were found in the cytoplasm of endothelial cells on electron microscopy. Conclusions: Although the clinical and histopathological features were similar to other forms of chilblains, the presence of viral particles in the endothelium and the histological evidence of vascular damage support a causal relation of the lesions with SARS‐CoV�?. Endothelial damage induced by the virus could be the key mechanism in the pathogenesis of COVID�?9 chilblains and perhaps also in a group of patients severely affected by COVID�?9 presenting with features of microangiopathic damage. What is already known about this topic? Despite the high number of cases of chilblains seen during the COVID�?9 pandemic, a definite causative role for SARS‐CoV�? has not yet been proven.Different pathogenetic hypotheses have been proposed, including coagulation anomalies, interferon release and external factors. What does this study add? The demonstration of SARS‐CoV�? in endothelial cells of skin biopsies by immunohistochemistry and electron microscopy confirms that these lesions are part of the spectrum of COVID�?9.Virus‐induced vascular damage and secondary ischaemia could explain the pathophysiology of COVID�?9 chilblains.Our findings support the hypothesis that widespread endothelial infection by SARS‐CoV�? could have a pathogenetic role in the severe forms of COVID�?9. Linked Comment:Wetter. Br J Dermatol 2020; 183:611. Linked Comment:Wetter. Br J Dermatol 2020; 183:611. Plain language summary available online [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146218157
AU  - Colmenero, I.
AU  - Santonja, C.
AU  - Alonso‐Riaño, M.
AU  - Noguera‐Morel, L.
AU  - Hern֙ndez‐Mart�Tn, A.
AU  - Andina, D.
AU  - Wiesner, T.
AU  - Rodr�Tguez‐Peralto, J. L.
AU  - Requena, L.
AU  - Torrelo, A.
C1  - 10/7/2020
DB  - a9h
DO  - 10.1111/bjd.19327
DP  - EBSCOhost
IS  - 4
M3  - Article
N1  - Colmenero, I. 1; Email Address: isabelcolmenero@gmail.com Santonja, C. 2 Alonso‐Riaño, M. 3 Noguera‐Morel, L. 4 Hern֙ndez‐Mart�Tn, A. 4 Andina, D. 5 Wiesner, T. 6 Rodr�Tguez‐Peralto, J.L. 3 Requena, L. 7 Torrelo, A. 4; Affiliation: 1: Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid Spain 2: Department of Pathology, Hospital Universitario Fundaci�Qn Jiménez D�Taz, Madrid Spain 3: Department of Pathology, Hospital Universitario 12 de Octubre, Madrid, Spain 4: Department of Dermatology, Hospital Infantil Universitario Niño Jesús, Madrid Spain 5: Emergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain 6: Department of Dermatology, Medical University of Vienna, Vienna, Austria 7: Department of Dermatology, Hospital Universitario Fundaci�Qn Jiménez D�Taz, Madrid, Spain; Source Info: Oct2020, Vol. 183 Issue 4, p729; Number of Pages: 9p; Document Type: Article; Full Text Word Count: 4708
PY  - 2020
SN  - 00070963
SP  - 729-737
ST  - SARS‐CoV�? endothelial infection causes COVID�?9 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases
T2  - British Journal of Dermatology
TI  - SARS‐CoV�? endothelial infection causes COVID�?9 chilblains: histopathological, immunohistochemical and ultrastructural study of seven paediatric cases
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146218157&site=ehost-live
VL  - 183
ID  - 7789380
ER  - 

TY  - JOUR
AB  - The Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) pandemic represents a global challenge. SARS-CoV-2's ability to replicate in host cells relies on the action of its non-structural proteins, like its main protease (Mpro). This cysteine protease acts by processing the viruses' precursor polyproteins. As proteases, together with polymerases, are main targets of antiviral drug design, we here have performed biochemical high throughput screening (HTS) with recombinantly expressed SARS-CoV-2 Mpro. A fluorescent assay was used to identify inhibitors in a compound library containing known drugs, bioactive molecules and natural products. These screens led to the identification of 13 inhibitors with IC50 values ranging from 0.2 μM to 23 μM. The screens confirmed several known SARS-CoV Mpro inhibitors as inhibitors of SARS-CoV-2 Mpro, such as the organo-mercuric compounds thimerosal and phenylmercuric acetate. Benzophenone derivatives could also be identified among the most potent screening hits. Additionally, Evans blue, a sulfonic acid-containing dye, could be identified as an Mpro inhibitor. The obtained compounds could be of interest as lead compounds for the development of future SARS-CoV-2 drugs.
AD  - Department of Science and Technology, Federal University of São Paulo, São José dos Campos, Brazil.
Department of Physics, University of South Florida, Tampa, FL, United States of America.
AN  - 33022015
AU  - Coelho, C.
AU  - Gallo, G.
AU  - Campos, C. B.
AU  - Hardy, L.
AU  - Würtele, M.
C1  - 10/7/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240079
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Coelho, Camila
Orcid: 0000-0002-6904-8681
Gallo, Gloria
Orcid: 0000-0002-6442-6604
Campos, Claudia B
Hardy, Leon
Würtele, Martin
Orcid: 0000-0001-8571-419x
Journal Article
United States
PLoS One. 2020 Oct 6;15(10):e0240079. doi: 10.1371/journal.pone.0240079. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240079
ST  - Biochemical screening for SARS-CoV-2 main protease inhibitors
T2  - PloS one
TI  - Biochemical screening for SARS-CoV-2 main protease inhibitors
VL  - 15
ID  - 7790989
ER  - 

TY  - JOUR
AU  - Claver�Tas, Laura
AU  - G�Qmez, Josep
AU  - Rodr�Tguez, Alejandro
AU  - Albiol, Jordi
AU  - Esteban, Federico
AU  - Bod�T, Mar�Ta
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Soporte a la organizaci�Qn de las Unidades de Cuidados Intensivos durante la pandemia, a través de mapas creados a partir de los Sistemas de Informaci�Qn Cl�Tnica
T2  - Medicina Intensiva
TI  - Soporte a la organizaci�Qn de las Unidades de Cuidados Intensivos durante la pandemia, a través de mapas creados a partir de los Sistemas de Informaci�Qn Cl�Tnica
UR  - https://doi.org/10.1016/j.medin.2020.08.006
ID  - 7792687
ER  - 

TY  - JOUR
AB  - We address the diffusion of information about the COVID-19 with a massive data analysis on Twitter, Instagram, YouTube, Reddit and Gab. We analyze engagement and interest in the COVID-19 topic and provide a differential assessment on the evolution of the discourse on a global scale for each platform and their users. We fit information spreading with epidemic models characterizing the basic reproduction number [Formula: see text] for each social media platform. Moreover, we identify information spreading from questionable sources, finding different volumes of misinformation in each platform. However, information from both reliable and questionable sources do not present different spreading patterns. Finally, we provide platform-dependent numerical estimates of rumors' amplification.
AD  - CNR-ISC, Rome, Italy.
Università Ca' Foscari di Venezia, Venice, Italy.
CNR-ISC, Rome, Italy. w.quattrociocchi@unive.it.
Università Ca' Foscari di Venezia, Venice, Italy. w.quattrociocchi@unive.it.
Big Data in Health Society, Rome, Italy. w.quattrociocchi@unive.it.
Università di Brescia, Brescia, Italy.
Politecnico di Milano, Milan, Italy.
CNR-IIT, Pisa, Italy.
Center for the Humanities and Social Change, Venice, Italy.
Big Data in Health Society, Rome, Italy.
AN  - 33024152
AU  - Cinelli, M.
AU  - Quattrociocchi, W.
AU  - Galeazzi, A.
AU  - Valensise, C. M.
AU  - Brugnoli, E.
AU  - Schmidt, A. L.
AU  - Zola, P.
AU  - Zollo, F.
AU  - Scala, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73510-5
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Cinelli, Matteo
Quattrociocchi, Walter
Galeazzi, Alessandro
Valensise, Carlo Michele
Brugnoli, Emanuele
Schmidt, Ana Lucia
Zola, Paola
Zollo, Fabiana
Scala, Antonio
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16598. doi: 10.1038/s41598-020-73510-5.
PY  - 2020
SN  - 2045-2322
SP  - 16598
ST  - The COVID-19 social media infodemic
T2  - Scientific reports
TI  - The COVID-19 social media infodemic
VL  - 10
ID  - 7790836
ER  - 

TY  - JOUR
AU  - Chuang, Tzu-Yi
AU  - Tsai, Ming-Han
AU  - Wu, Lit-Min
AU  - Ho, Sung-Jung
AU  - Yeh, Pu-Sheng
AU  - Liu, Yi-Lien
AU  - Fred Yang, Hung-Jen
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Successful treatment of tocilizumab and ivermectin for a patient with ARDS due to COVID-19
T2  - Journal of Microbiology, Immunology and Infection
TI  - Successful treatment of tocilizumab and ivermectin for a patient with ARDS due to COVID-19
UR  - https://doi.org/10.1016/j.jmii.2020.09.007
ID  - 7793123
ER  - 

TY  - JOUR
AB  - Prenatal COVID infection is one of the worst affected and least attended aspects of the COVID-19 disease Like other coronaviruses, CoV2 infection is anticipated to affect fetal development by maternal inflammatory response on the fetus and placenta Studies showed that higher prenatal choline level in mother’s body can safeguard the developing brain of the fetus from the adverse effects of CoV2 infection Choline is commonly used as food supplement By virtual screening, molecular docking and molecular dynamics techniques, we have established a strong inhibitory possibility of choline for SARS 3CLpro protease which may provide a lead for prenatal COVID-19 treatment
AU  - Chowdhury, Papia
AU  - Pathak, Pustak
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Neuroprotective Immunity by Essential Nutrient “Choline�?for the Prevention of SARS CoV2 Infections: An In Silico Study by Molecular Dynamics Approach
T2  - Chemical Physics Letters
TI  - Neuroprotective Immunity by Essential Nutrient “Choline�?for the Prevention of SARS CoV2 Infections: An In Silico Study by Molecular Dynamics Approach
UR  - https://doi.org/10.1016/j.cplett.2020.138057
ID  - 7793196
ER  - 

TY  - JOUR
AB  - The rapid spread of COVID-19 has led to nationwide lockdowns in many countries. The COVID-19 pandemic has played serious havoc on economic activities throughout the world. Researchers are immensely curious about how to give the best protection to people before a vaccine becomes available. The coronavirus spreads principally through saliva droplets. Thus, it would be a great opportunity if the virus spread could be controlled at an early stage. The face mask can limit virus spread from both inside and outside the mask. This is the first study that has endeavoured to explore the design and fabrication of an antiviral face mask using licorice root extract, which has antimicrobial properties due to glycyrrhetinic acid (GA) and glycyrrhizin (GL). An electrospinning process was utilized to fabricate nanofibrous membrane and virus deactivation mechanisms discussed. The nanofiber mask material was characterized by SEM and airflow rate testing. SEM results indicated that the nanofibers from electrospinning are about 15-30 μm in diameter with random porosity and orientation which have the potential to capture and kill the virus. Theoretical estimation signifies that an 85 L/min rate of airflow through the face mask is possible which ensures good breathability over an extensive range of pressure drops and pore sizes. Finally, it can be concluded that licorice root membrane may be used to produce a biobased face mask to control COVID-19 spread.
AD  - Department of Mechanical Engineering, Dhaka University of Engineering and Technology (DUET), Gazipur-1707, Bangladesh. Electronic address: asadzmn2014@yahoo.com.
Department of Mechanical Engineering, Dhaka University of Engineering and Technology (DUET), Gazipur-1707, Bangladesh; National Institute of Textile Engineering and Research (NITER), Savar, Dhaka-1350, Bangladesh.
Department of Textile Engineering, Dhaka University of Engineering and Technology (DUET), Gazipur-1707, Bangladesh.
National Institute of Textile Engineering and Research (NITER), Savar, Dhaka-1350, Bangladesh.
Department of Computer Science and Engineering, Dhaka University of Engineering and Technology (DUET), Gazipur-1707, Bangladesh.
Pyrolysis Technology Research Group, Institute of Tropical Aquaculture and Fisheries (Akuatrop), Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia.
School of Information, Systems and Modelling, Faculty of Engineering and IT, University of Technology Sydney, NSW 2007, Australia.
Department of Civil Engineering, College of Engineering, Jouf University, Sakaka, Saudi Arabia.
School of Information, Systems and Modelling, Faculty of Engineering and IT, University of Technology Sydney, NSW 2007, Australia; Mechanical Engineering Department, Prince Mohammad Bin Fahd University, Al Khobar 31952, Saudi Arabia.
AN  - 33022215
AU  - Chowdhury, M. A.
AU  - Ahmed Shuvho, M. B.
AU  - Shahid, M. A.
AU  - Haque, Akmm
AU  - Kashem, M. A.
AU  - Lam, S. S.
AU  - Ong, H. C.
AU  - Uddin, M. A.
AU  - Mofijur, M.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1016/j.envres.2020.110294
DP  - NLM
ET  - 2020/10/07
J2  - Environmental research
KW  - Antiviral Mask
Covid-19
Licorice Root
Membrane
Nanofibers
SEM
competing financial interests or personal relationships that could have appeared to
influence the work reported in this paper.
LA  - eng
N1  - 1096-0953
Chowdhury, Mohammad Asaduzzaman
Ahmed Shuvho, Md Bengir
Shahid, Md Abdus
Haque, A K M Monjurul
Kashem, Mohammod Abul
Lam, Su Shiung
Ong, Hwai Chyuan
Uddin, Md Alhaz
Mofijur, M
Journal Article
Netherlands
Environ Res. 2020 Oct 3:110294. doi: 10.1016/j.envres.2020.110294.
PY  - 2020
SN  - 0013-9351
SP  - 110294
ST  - Prospect of biobased antiviral face mask to limit the coronavirus outbreak
T2  - Environmental research
TI  - Prospect of biobased antiviral face mask to limit the coronavirus outbreak
ID  - 7790976
ER  - 

TY  - JOUR
AB  - OBJECTIVE: The aim of this study was to analyze the available knowledge about the potential association between dyslipidemia and the severity of coronavirus disease 2019 (COVID-19) as reported in previous published systematic reviews. METHODS: In this umbrella review (an overview of systematic reviews), we investigated the association between dyslipidemia and COVID-19 severity. A systematic search was performed of 4 main electronic databases (MEDLINE, Embase, Scopus, and the Cochrane Library databases) from inception until August 2020. We evaluated the methodological quality of the included studies using the A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2 tool and used the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to assess the quality of evidence for the outcome. In addition, we evaluated the strengths and limitations of the evidence and the methodological quality of the available studies. RESULTS: Out of 35 articles identified, 2 systematic reviews were included in the umbrella review. A total of 7,951 COVID-19-positive patients were included. According to the AMSTAR 2 criteria and GRADE system, the quality of the included studies was not high. A history of dyslipidemia is likely to be associated with the severity of COVID-19 infection, but the contrary is the case for cholesterol levels at hospitalization. CONCLUSIONS: Although existing research on dyslipidemia and COVID-19 is limited, our findings suggest that dyslipidemia may play a role in the severity of COVID-19 infection. More adequately powered studies are needed. TRIAL REGISTRATION: PROSPERO Identifier: CRD42020205979.
AD  - Department of Anesthesiology and Pain Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
The institute of Evidence based clinical medicine, Chung-Ang University, Seoul, Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
AN  - 33024735
AU  - Choi, G. J.
AU  - Kim, H. M.
AU  - Kang, H.
C1  - 10/7/2020
C2  - PMC7521969
DA  - Sep
DB  - PubMed
DO  - 10.12997/jla.2020.9.3.435
DP  - NLM
ET  - 2020/10/08
IS  - 3
J2  - Journal of lipid and atherosclerosis
KW  - Covid-19
Cholesterol
Dyslipidemias
Hyperlipidemias
severe acute respiratory syndrome coronavirus 2
Kim and Hyun Kang are editors of Journal of Lipid and Atherosclerosis
however, they
were not involved in the peer reviewer selection, evaluation, or decision process of
this article. No other potential conflicts of interest relevant to this article were
reported.
LA  - eng
N1  - Choi, Geun Joo
Orcid: 0000-0002-4653-4193
Kim, Hyun Min
Orcid: 0000-0002-7460-9340
Kang, Hyun
Orcid: 0000-0003-2844-5880
Journal Article
Korea (South)
J Lipid Atheroscler. 2020 Sep;9(3):435-448. doi: 10.12997/jla.2020.9.3.435. Epub 2020 Sep 21.
PY  - 2020
SN  - 2287-2892 (Print)
2287-2892
SP  - 435-448
ST  - The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews
T2  - Journal of lipid and atherosclerosis
TI  - The Potential Role of Dyslipidemia in COVID-19 Severity: an Umbrella Review of Systematic Reviews
VL  - 9
ID  - 7790773
ER  - 

TY  - GEN
AD  - Department of Anesthesia and Intensive Care, ASST Santi Paolo e Carlo, San Paolo University Hospital, Milan, Italy
Department of Health Sciences, University of Milan, Milan, Italy
Coordinated Research Center on Respiratory Failure, University of Milan, Milan, Italy
Department of Emergenza Urgenza, UOC Anestesia e Rianimazione, ASST, Lodi, Italy
AU  - Chiumello, Davide
AU  - Pozzi, Tommaso
AU  - Storti, Enrico
AU  - Caccioppola, Alessio
AU  - Pontiroli, Antonio E.
AU  - Coppola, Silvia
C1  - 10/7/2020
CY  - New York, New York
DB  - cin20
DO  - 10.1016/j.bja.2020.07.006
DP  - EBSCOhost
J2  - BJA: The British Journal of Anaesthesia
KW  - Coronavirus Infections -- Complications
Pneumonia, Viral -- Physiopathology
Respiratory Distress Syndrome, Acute -- Physiopathology
Coronavirus Infections -- Physiopathology
Pneumonia, Viral -- Complications
Respiratory Distress Syndrome, Acute -- Complications
Body Mass Index
Coronavirus Infections -- Epidemiology
Aged
Disease Outbreaks
Respiratory Function Tests
Retrospective Design
Female
Male
Pneumonia, Viral -- Epidemiology
Middle Age
Critical Care
Obesity -- Complications
Respiratory Distress Syndrome, Acute -- Epidemiology
N1  - Accession Number: 145887995. Language: English. Entry Date: 20200928. Revision Date: 20201003. Publication Type: letter. Journal Subset: Biomedical; Europe; Peer Reviewed; UK & Ireland. NLM UID: 0372541.
PMID: NLM32741541.
PB  - Elsevier B.V.
PY  - 2020
SN  - 0007-0912
SP  - e376-e377
ST  - Body mass index and acute respiratory distress severity in patients with and without SARS-CoV-2 infection
TI  - Body mass index and acute respiratory distress severity in patients with and without SARS-CoV-2 infection
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=145887995&site=ehost-live
VL  - 125
ID  - 7790419
ER  - 

TY  - JOUR
AB  - Starting in mid-May 2020, many US states began relaxing social-distancing measures that were put in place to mitigate the spread of COVID-19. To evaluate the impact of relaxation of restrictions on COVID-19 dynamics and control, we developed a transmission dynamic model and calibrated it to US state-level COVID-19 cases and deaths. We used this model to evaluate the impact of social distancing, testing and contact tracing on the COVID-19 epidemic in each state. As of 22 July 2020, we found that only three states were on track to curtail their epidemic curve. Thirty-nine states and the District of Columbia may have to double their testing and/or tracing rates and/or rolling back reopening by 25%, while eight states require an even greater measure of combined testing, tracing and distancing. Increased testing and contact-tracing capacity is paramount for mitigating the recent large-scale increases in US cases and deaths.
AD  - Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. wchiu@tamu.edu.
Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX, USA.
Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, USA. m.ndeffo@tamu.edu.
Department of Epidemiology and Biostatistics, School of Public Health, Texas A&M University, College Station, TX, USA. m.ndeffo@tamu.edu.
AN  - 33024280
AU  - Chiu, W. A.
AU  - Fischer, R.
AU  - Ndeffo-Mbah, M. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41562-020-00969-7
DP  - NLM
ET  - 2020/10/08
J2  - Nature human behaviour
LA  - eng
N1  - 2397-3374
Chiu, Weihsueh A
Orcid: 0000-0002-7575-2368
Fischer, Rebecca
Ndeffo-Mbah, Martial L
Orcid: 0000-0003-4158-7613
P30 ES029067/ES/NIEHS NIH HHS/United States
NSF RAPID DEB 2028632/National Science Foundation (NSF)/
Journal Article
England
Nat Hum Behav. 2020 Oct 6. doi: 10.1038/s41562-020-00969-7.
PY  - 2020
SN  - 2397-3374
ST  - State-level needs for social distancing and contact tracing to contain COVID-19 in the United States
T2  - Nature human behaviour
TI  - State-level needs for social distancing and contact tracing to contain COVID-19 in the United States
ID  - 7790829
ER  - 

TY  - JOUR
AU  - Chiu, Pao-Lung
AU  - Yu, Yi-Ming
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Resilience and Covid-19: action plans and strategies in a military community
T2  - Asia Pacific Journal of Social Work and Development
TI  - Resilience and Covid-19: action plans and strategies in a military community
UR  - https://doi.org/10.1080/02185385.2020.1828156
ID  - 7792985
ER  - 

TY  - JOUR
AU  - Chithra, Nellai K.
AU  - Kandasamy, Arun
AU  - Muralidharan, Kesavan
AU  - Gangadhar, Bangalore N.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - From asylums to bedless hospitals: will COVID-19 catalyse a paradigm shift in psychiatry care in India?
T2  - Asian Journal of Psychiatry
TI  - From asylums to bedless hospitals: will COVID-19 catalyse a paradigm shift in psychiatry care in India?
UR  - https://doi.org/10.1016/j.ajp.2020.102428
ID  - 7793248
ER  - 

TY  - JOUR
AD  - Center of Biological Sciences and Health, University of Vale do Taquari, Avelino Talini St. Lajeado, RS, Brazil.
Federal University of Pelotas, Pelotas, RS, Brazil.
Department of Restorative Dentistry, School of Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil.
AN  - 33022779
AU  - Chisini, L. A.
AU  - Sartori, L.
AU  - Dos Santos Costa, F.
AU  - Carla Salvi, L.
AU  - Demarco, F. F.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/odi.13668
DP  - NLM
ET  - 2020/10/07
J2  - Oral diseases
KW  - Covid-19
Coronavirus Infections
Pandemic
Prothesis
Public Health System
LA  - eng
N1  - 1601-0825
Chisini, Luiz Alexandre
Orcid: 0000-0002-3695-0361
Sartori, Let�Tcia
Dos Santos Costa, Francine
Orcid: 0000-0001-9558-937x
Carla Salvi, Luana
Demarco, Fl֙vio Fernando
Orcid: 0000-0003-2276-491x
Letter
Denmark
Oral Dis. 2020 Oct 6. doi: 10.1111/odi.13668.
PY  - 2020
SN  - 1354-523x
ST  - COVID-19 pandemic impact on prosthetic treatments in the Brazilian Public Health System
T2  - Oral diseases
TI  - COVID-19 pandemic impact on prosthetic treatments in the Brazilian Public Health System
ID  - 7790945
ER  - 

TY  - JOUR
AB  - The coronavirus disease (COVID-19) is caused by Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and presents with respiratory symptoms which can be life threatening in severe cases. At the start of the pandemic, allergy, asthma, and chronic obstructive pulmonary disease (COPD) were considered as risk factors for COVID-19 as they tend to exacerbate during respiratory viral infections. Recent literature has not shown that airway allergic diseases is a high-risk factor or that it increases the severity of COVID-19. This is due to a decrease in Angiotensin-converting enzyme 2 (ACE2) gene expression in the nose and bronchial cells of allergic airway diseases. Conventional asthma treatment includes inhaled corticosteroids (ICS), allergen immunotherapy (AIT), and biologics, and should be continued as they might reduce the risks of asthmatics for coronavirus infection by enhancing antiviral defence and alleviating inflammation.
AD  - Mumbai Port Trust Hospital, Mumbai, India. drsunita7ent@yahoo.co.in.
AN  - 33025046
AU  - Chhapola Shukla, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00405-020-06408-7
DP  - NLM
ET  - 2020/10/08
J2  - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
KW  - Allergen immunotherapy (AIT)
Allergic rhinitis
Angiotensin-converting enzyme 2 (ACE2)
Asthma
Covid-19
Inhaled corticosteroids (ICS)
SARS-CoV-2
Transmembrane protease serine 2 (TMPRSS2)
LA  - eng
N1  - 1434-4726
Chhapola Shukla, Sunita
Orcid: 0000-0002-0000-2634
Journal Article
Germany
Eur Arch Otorhinolaryngol. 2020 Oct 6. doi: 10.1007/s00405-020-06408-7.
PY  - 2020
SN  - 0937-4477
ST  - ACE2 expression in allergic airway disease may decrease the risk and severity of COVID-19
T2  - European archives of oto-rhino-laryngology : official journal of European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
TI  - ACE2 expression in allergic airway disease may decrease the risk and severity of COVID-19
ID  - 7790725
ER  - 

TY  - JOUR
AU  - Chernin, Natan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Threat of the Bio-Lone Wolf to National Security: A Covid-19 Perspective
T2  - Israel Journal of Foreign Affairs
TI  - The Threat of the Bio-Lone Wolf to National Security: A Covid-19 Perspective
UR  - https://doi.org/10.1080/23739770.2020.1822096
ID  - 7792939
ER  - 

TY  - JOUR
AU  - Chen, Yan-Yan
AU  - Zhuang, Jie
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Roles of medical social workers in interprofessional teams: a case study of a Shanghai COVID-19 quarantine centre for medical observation
T2  - Asia Pacific Journal of Social Work and Development
TI  - Roles of medical social workers in interprofessional teams: a case study of a Shanghai COVID-19 quarantine centre for medical observation
UR  - https://doi.org/10.1080/02185385.2020.1828157
ID  - 7792984
ER  - 

TY  - JOUR
AU  - Chen, Y. Y.
AU  - Li, Y.
AU  - Li, C. J.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Could artificial intelligence make human doctors obsolete? A survey based on public attitudes
T2  - European Journal of Public Health
TI  - Could artificial intelligence make human doctors obsolete? A survey based on public attitudes
UR  - https://doi.org/10.1093/eurpub/ckaa166.040
ID  - 7792909
ER  - 

TY  - JOUR
AB  - SUMMARY Coronavirus disease 2019 (COVID-19) has become a severe threat to human health worldwide Early etiological diagnosis plays a critical role in controlling COVID-19 pandemic However, etiological diagnosis has been largely compromised by high &quot;false negative&quot; rates of viral nucleic acid testing, resulting from limited sampling efficiency using conventional oropharyngeal swabs Herein, we engineer regular swabs by using a microneedle (MN) patch to significantly improve the quality and quantity of virus collection The combination of MNs with different crosslinking levels endows the patches with dual capability of mucus penetration and virus extraction Moreover, the antibody (Ab) against viral spike protein was integrated into the patch, conferring MNs with an active virus capture potential By taking advantage of the biological and engineered species, it is believed the designed MN/Ab swabs could serve as a promising tool to improve current sampling efficiency with less &quot;false negatives&quot;, contributing to the containment of COVID-19 pandemic
AU  - Chen, Wei
AU  - Cai, Bo
AU  - Geng, Zhi
AU  - Chen, Fenghua
AU  - Wang, Zheng
AU  - Wang, Lin
AU  - Chen, Xiaoyuan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs
T2  - Matter
TI  - Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs
UR  - https://doi.org/10.1016/j.matt.2020.09.021
ID  - 7793106
ER  - 

TY  - JOUR
AB  - BACKGROUND: To evaluate the association between crowding and transmission of viral respiratory infectious diseases, we investigated the change in transmission patterns of influenza and COVID-19 before and after a mass gathering event (i.e., carnival) in the Netherlands. METHODS: Information on individual hospitalizations related to the 2017/2018 influenza epidemic were accessed from Statistics Netherlands. The influenza cases were stratified between non-carnival and carnival regions. Distributions of influenza cases were plotted with time and compared between regions. A similar investigation in the early outbreak of COVID-19 was also conducted using open data from the Dutch National Institute for Public Health and the Environment. RESULTS: Baseline characteristics between non-carnival and carnival regions were broadly similar. There were 13,836 influenza-related hospitalizations in the 2017/2018 influenza epidemic, and carnival fell about 1 week before the peak of these hospitalizations. The distributions of new influenza-related hospitalizations per 100,000 inhabitants with time between regions followed the same pattern with a surge of new cases in the carnival region about 1 week after carnival, which did not occur in the non-carnival region. The increase of new cases for COVID-19 in the carnival region exceeded that in the non-carnival region about 1 week after the first case was reported, but these results warrant caution as for COVID-19 there were no cases reported before the carnival and social measures were introduced shortly after carnival. CONCLUSION: In this study, a mass gathering event (carnival) was associated with aggravating the spread of viral respiratory infectious diseases.
AD  - Department of Clinical Epidemiology, Leiden University Medical Center, Box 9600, Albinusdreef 2, Leiden, 2300 RC, The Netherlands.
Department of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Department of Clinical Epidemiology, Leiden University Medical Center, Box 9600, Albinusdreef 2, Leiden, 2300 RC, The Netherlands. w.m.lijfering@lumc.nl.
AN  - 33023561
AU  - Chen, Q.
AU  - Toorop, M. M. A.
AU  - de Boer, M. G. J.
AU  - Rosendaal, F. R.
AU  - Lijfering, W. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s12889-020-09612-6
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - BMC public health
KW  - Covid-19
Epidemiology
Influenza
Mass gathering medicine
LA  - eng
N1  - 1471-2458
LUMC-COVID-19 Research Group
Chen, Qingui
Toorop, Myrthe M A
de Boer, Mark G J
Rosendaal, Frits R
Lijfering, Willem M
Journal Article
England
BMC Public Health. 2020 Oct 6;20(1):1516. doi: 10.1186/s12889-020-09612-6.
PY  - 2020
SN  - 1471-2458
SP  - 1516
ST  - Why crowding matters in the time of COVID-19 pandemic? - a lesson from the carnival effect on the 2017/2018 influenza epidemic in the Netherlands
T2  - BMC public health
TI  - Why crowding matters in the time of COVID-19 pandemic? - a lesson from the carnival effect on the 2017/2018 influenza epidemic in the Netherlands
VL  - 20
ID  - 7790903
ER  - 

TY  - JOUR
AB  - An outbreak of pneumonia proved to be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), named Coronavirus Disease 2019 (COVID-19) by World Health Organization (WHO), has rapidly and widely spread to the whole world, affecting thousands of people COVID-19 patients have poor gastrointestinal function and microecological disorders, which lead to the frequent occurrence of aspiration pneumonia, gastric retention, and diarrhea In the meanwhile, it takes a certain period of time for nutrition therapy to reach the patient&#039;s physiological amount Refeeding syndrome and hypoglycemia may occur during this period, causing the high risk of death in critical patients Therefore, we reported the nutrition therapy and side-effects monitoring as well as the adjustment of the nutrition therapy of 2 critical COVID-19 patients, thus provide clinical evidence for nutrition therapy and prevention of the side effects
AU  - Chen, Hanxiao
AU  - Xue, Yu
AU  - Yu, He
AU  - Chen, Hong
AU  - Li, Yang
AU  - Chen, Yi
AU  - Zhang, Yuwei
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Case report: Nutrition therapy and side-effects monitoring in critically ill coronavirus disease 2019 patients
T2  - Heart & Lung
TI  - Case report: Nutrition therapy and side-effects monitoring in critically ill coronavirus disease 2019 patients
UR  - https://doi.org/10.1016/j.hrtlng.2020.08.027
ID  - 7793167
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has caused untold fear and suffering for older adults across the world According to the World Health Organization, older adults in aged care homes are at a higher risk of the infection living in an enclosed environment with others This article adopts a qualitative approach using Colaizzi?s phenomenological method to explore the lived experiences of older adults during COVID-19 Between December 2019 and June 2020, 10 in-depth, semi-structured interviews were conducted with participants aged 60 years and above in two aged care homes The lived tension that has penetrated all participants? stories in five themes of the meanings described as ?disconnected in a shrinking world? filled with uncertainties COVID-19 has brought unprecedented challenges and disproportionate threat onto older adults? lives, relationships and well-being The overarching message was that older adults believe that ?this too shall pass? and regain their freedom that was lost during the pandemic
AU  - Chee, Shi Yin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 Pandemic: The Lived Experiences of Older Adults in Aged Care Homes
T2  - Millennial Asia
TI  - COVID-19 Pandemic: The Lived Experiences of Older Adults in Aged Care Homes
UR  - https://doi.org/10.1177/0976399620958326
ID  - 7792825
ER  - 

TY  - JOUR
AB  - Objective To introduce a new method to do safe bronchoscopy, a highly aerosol generating procedure through disposable COVID box in this difficult COVID time Methods We have introduced an unbelievably cheap and effective method &quot;DISPOSABLE COVID BOX&quot; We took an acrylic board 70 X 20 cm and attached 3 bars 32 cm long and slide it under the side of the patient A similar contraption is used on the other side Then, it is covered by a polypropylene sheet 2�?X 2�?It makes a completely disposable airtight chamber with the polypropylene sheet We make a 1 cm nick in the sheet and introduce the video-bronchoscope, which is further navigated into the patient without any discomfort either to the patient or Bronchoscopist When the procedure is finished, scope is withdrawn from the patient and the polypropylene sheet is squeezed out The polypropylene sheet is removed and disposed off with all precautions, and the acrylic boards and the bars are cleaned with 1% Sodium hypochlorite solution This way, the cost is only of polypropylene sheet which is negligible Results Videobronchoscopies in indicated patients were done using this novel disposable covid box This new invention called Disposable COVID box has been practiced for the first time, it’s an innovative technique about which we want the world to be known Conclusion To conclude, there are no aerosols released in atmosphere after the procedure, making it absolutely safe for bronchoscopist and at same time patient also remains safe We are ready again in no time with fresh polypropylene sheet to do the next bronchoscopy
AU  - Chawla, Rakesh K.
AU  - Chawla, Aditya K.
AU  - Madan, Arun
AU  - Chopra, Kamal
AU  - Chaudhary, Gaurav
AU  - Chawla, Madhav K.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - DISPOSABLE COVID BOX �?A new invention
T2  - Indian Journal of Tuberculosis
TI  - DISPOSABLE COVID BOX �?A new invention
UR  - https://doi.org/10.1016/j.ijtb.2020.09.024
ID  - 7793156
ER  - 

TY  - JOUR
AB  - How to cite this article: Chawla R, Nasa P. Ventilatory Management of COVID-19-related ARDS: Stick to Basics and Infection Control. Indian J Crit Care Med 2020;24(8):609-610.
AD  - Department of Respiratory and Critical Care Medicine, Indraprastha Apollo Hospitals, Sarita Vihar, New Delhi, India.
Department of Critical Care Medicine, NMC Specialty Hospital, Dubai (UAE).
AN  - 33024358
AU  - Chawla, R.
AU  - Nasa, P.
C1  - 10/7/2020
C2  - PMC7519619
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23513
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Acute respiratory distress syndrome
Covid-19
Ventilation
LA  - eng
N1  - Chawla, Rajesh
Nasa, Prashant
Editorial
India
Indian J Crit Care Med. 2020 Aug;24(8):609-610. doi: 10.5005/jp-journals-10071-23513.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 609-610
ST  - Ventilatory Management of COVID-19-related ARDS: Stick to Basics and Infection Control
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - Ventilatory Management of COVID-19-related ARDS: Stick to Basics and Infection Control
VL  - 24
ID  - 7790810
ER  - 

TY  - JOUR
AU  - Chauffier, Jeanne
AU  - Poey, Nora
AU  - Husain, Maya
AU  - Broucker, Thomas De
AU  - Khalil, Antoine
AU  - Lariven, Sylvie
AU  - Henry-Feugeas, Marie-Cécile
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - First Case of Mild Encephalopathy with Reversible Splenial Lesion in SARS-CoV-2 Infection
T2  - Médecine et Maladies Infectieuses
TI  - First Case of Mild Encephalopathy with Reversible Splenial Lesion in SARS-CoV-2 Infection
UR  - https://doi.org/10.1016/j.medmal.2020.09.018
ID  - 7793094
ER  - 

TY  - JOUR
AB  - Background This study was done to understand the effect of temperature and precipitation in COVID-19. Objective To study the effect of temperature and precipitation on transmission of COVID-19. To study the effect of temperature and precipitation on daily death of COVID-19. Methodology We collected 3 consecutive month data of seven cities around the world which were effected most by the COVID-19. Data included weather variables i.e temperature (average temperature, maximum temperature and minimum temperature), precipitation, daily new cases and daily new death. Conclusion Increase in average temperature reduces daily death and increase in maximum temperature reduces transmission.Competing Interest StatementThe authors have declared no competing interest.Funding Statementno funding was given for this studyAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:the data was collected from public domain and its mentioned in manuscriptAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll the data have been collected from the public domain present in interner
AU  - Chaudhary, Amar Prashad
AU  - Nelson K, Adna
AU  - S, Harish
AU  - S, mythily
AU  - Kj, Chaithanya
AU  - nayak, lovely
AU  - sah, chiranjibi
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206227
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206227
ST  - Effect of temperature and precipitation on the daily new cases and daily new death in seven cities around the globe (preprint)
T2  - medRxiv
TI  - Effect of temperature and precipitation on the daily new cases and daily new death in seven cities around the globe (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206227.abstract
ID  - 7794743
ER  - 

TY  - JOUR
AB  - Introduction There is limited data on clinical course and outcomes of hospitalized adults with COVID-19 in Nepal. Thus, it is imperative to characterize the features of this disease in the domestic context. Methodology We identified all adult patients with laboratory-confirmed COVID-19 admitted to five different hospitals in Nepal from June 15 to July 15, 2020. We collected epidemiological, socio-cultural and clinicopathologic data, and stratified the patients based on their symptom status. Results The study included 220 patients with an overall median age of 31.5 (25-37) years, and 181 (82.3%) were males. 159 (72.3%) were asymptomatic, and 163 (74.1%) were imported cases. Of 217 patients with the available data, 110 (50.7%) reported their annual household income less than 2000 US dollars, and 122 (56.2%) practiced Pranayama (yogic rhythmic breathing techniques) regularly. Eight patients (3.6%) required supplemental oxygen and two patients (0.9%) died. None of the patients who practiced Pranayama regularly required supplemental oxygen. Compared to asymptomatic patients, symptomatic patients had greater proportion of females (31.1% vs. 12.6%, p=0.001), imported cases (85.2% vs. 69.8%, p=0.02), illiterates (26.8% vs. 12.1%, p=0.01), alcohol users (43.3% vs. 24.5%, p=0.01), patients feeling stigmatized by society (45.8% vs. 22.6%, p=0.001), and had higher platelet count (253 x 10^9/L vs. 185 x10^9/L, p=0.02). Conclusions Most cases were imported, asymptomatic young males, with very few deaths. Pranayama practice was associated with protection against severe COVID-19, but more data is needed to substantiate this. The association of platelets count with symptom status in the Nepalese population needs further exploration.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported in part by the Ministry of Social Development, Sudurpaschim Province, Nepal (Grant number 332-2020). The funders had no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the article for publication. All authors had full access to all of the data (including statistical reports and tables) in the study and take full responsibility for the integrity of the data and the accuracy of the data analysis.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Ethical Review Board of Nepal Health Research Council approved this study (Approval ID: 443/2020 P).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAdditional data is available by emailing the corresponding author at ashokchaudhary2017@gmail.com.
AU  - Chaudhary, Ashok
AU  - Singh, Uday Narayan
AU  - Paudel, Pramod
AU  - Thapa, Niresh
AU  - Khadka, Kamal
AU  - Sah, Prameshwar Kumar
AU  - Kamar, Sher Bahadur
AU  - Joshi, Jagadish
AU  - Ansari, Kamar Hasan
AU  - Tiwari, Shree Ram
AU  - Sharma, Sarbesh
AU  - Jaiswal, Sanjay Kumar
AU  - Joshi, Ramesh
AU  - Baskota, Samikchya
AU  - Tiwari, Arjun Prasad
AU  - Pandey, Hem Raj
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206128
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206128
ST  - Characteristics and outcomes of hospitalized adults with COVID-19 in Nepal: a multicenter, prospective cohort study (preprint)
T2  - medRxiv
TI  - Characteristics and outcomes of hospitalized adults with COVID-19 in Nepal: a multicenter, prospective cohort study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.03.20206128.abstract
ID  - 7794731
ER  - 

TY  - JOUR
AB  - ABSTRACT Background The case fatality ratio (CFR) of coronavirus disease 2019 (COVID-19) has been reported to be variable among different countries and regions but few analyses have tracked this ratio worldwide over time. Methods The primary objective was to assess the time-course evolution of CFR of COVID-19 in all countries with available data and secondary objective was to evaluate associations between country-wise CFR and country-level health, human development, demographic and economic parameters. Day-wise data of COVID-19 cases and deaths for each country was extracted from a public repository and countries with at least 1000 cases on cutoff date were clustered by unsupervised kmeans on the basis of deaths per 100000 population (DP100K). Day-wise CFR (cumulative deaths divided by cumulative cases, multiplied by 100) for each country and cluster (country group) was plotted as time-series and country-level parameters were tested for association with CFR using weighted multiple linear regression. Results On September 24, 2020 there were 32140504 cumulative COVID-19 cases and 981792 deaths reported from 184 countries for a worldwide CFR of 3.06 % (95%CI 3.05 -3.07). Unsupervised k-means clustering in 157 countries with at least 1000 reported cases resulted in Clusters (country groups) A, B, C, D and E with centroid DP100K and CFR of 0.100 and 2.51 (95% CI 2.42-2.61), 0.503 and 2.28 (95% CI 2.23-2.33), 1.816 and 1.73 (95% CI 1.71-1.75), 7.395 and 1.76 (95% CI 1.75-1.76),4 and 36.303 and 3.82 (95% CI 3.82-3.83), respectively. In a log-log analysis DP100K and CFR were significantly positively correlated (R=0.3570, p&amp;lt;0.001) with each other. All country groups and majority of included countries showed a pattern of gradually increasing CFR from the beginning of pandemic, followed by a plateau and then a steady decline in CFR. Among 10 country-level parameters, GDP per capita (β=-0.483, p=0.000), hospital beds per population (β=-0.372, p&amp;lt;0.001), mortality from air pollution (β=-0.487, p=0.003) and population density (β=-0.570, p&amp;lt; 0.000) were significantly negatively associated while maternal mortality ratio (β=0.431, p=0.000) and age (β=0.635, p&amp;lt;0.000) were positively associated with CFR. Conclusions The CFR of COVID-19 has gradually increased over time in majority of countries at various stages of the pandemic, followed by a plateau and a steady decline. Population level COVID-19 mortality burden and CFR are significantly positively associated with each other.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThere was no funding available for this study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Ethics Declaration: This analysis was performed by academic researchers from a large tertiary cancer centre in India. Institutional ethics committee approval was not sought for this analysis, as per institutional guidelines, because it did not involve collection or handling of individual patient data. All the raw data used in this analysis is available as supplementary filesAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll the raw data used in this analysis is available as supplementary files
AU  - Chaubal, Rohan
AU  - Kannan, Sadhana
AU  - Khattry, Navin
AU  - Gupta, Sudeep
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206599
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206599
ST  - WORLDWIDE CASE FATALITY RATIO OF COVID-19 OVER TIME (preprint)
T2  - medRxiv
TI  - WORLDWIDE CASE FATALITY RATIO OF COVID-19 OVER TIME (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206599.abstract
ID  - 7794776
ER  - 

TY  - JOUR
AB  - Since the beginning of the COVID-19 outbreak, SARS-CoV-2 whole-genome sequencing (WGS) has been performed at unprecedented rate worldwide with the use of very diverse Next Generation Sequencing (NGS) methods Herein, we compare the performance of four NGS-based approaches for SARS-CoV-2 WGS Twenty four clinical respiratory samples with a large scale of Ct values (from 10 7 to 33 9) were sequenced with four methods Three used Illumina sequencing: an in-house metagenomic NGS (mNGS) protocol and two newly commercialized kits including a hybridization capture method developed by Illumina (DNA Prep with Enrichment kit and Respiratory Virus Oligo Panel, RVOP) and an amplicon sequencing method developed by Paragon Genomics (CleanPlex SARS-CoV-2 kit) We also evaluated the widely used amplicon sequencing protocol developed by ARTIC Network and combined with Oxford Nanopore Technologies (ONT) sequencing All four methods yielded near-complete genomes (&amp;amp;gt;99%) for high viral loads samples (n�?�?), with mNGS and RVOP producing the most complete genomes For mid viral loads (Ct 20-25), amplicon-based enrichment methods led to genome coverage &amp;amp;gt;99% for all samples while 1/8 sample sequenced with RVOP and 2/8 samples sequenced with mNGS had a genome coverage below 99% For low viral loads (Ct ≥�?5), amplicon-based enrichment methods were the most sensitive techniques All methods were highly concordant in terms of identity in complete consensus sequence Just one mismatch in three samples was observed in CleanPlex vs the other methods, due to the dedicated bioinformatics pipeline setting a high threshold to call SNP compared to reference sequence Importantly, all methods correctly identified a newly observed 34-nt deletion in ORF6 but required specific bioinformatic validation for RVOP Finally, as a major warning for targeted techniques, a loss of coverage in any given region of the genome should alert to a potential rearrangement or a SNP in primer annealing or probe-hybridizing regions and would require further validation using unbiased metagenomic sequencing
AU  - Charre, Caroline
AU  - Ginevra, Christophe
AU  - Sabatier, Marina
AU  - Regue, Hadrien
AU  - Destras, Grégory Brun
AU  - Solenne, Burfin
AU  - Gwendolyne, Scholtes
AU  - Caroline, Morfin
AU  - Florence, Valette
AU  - Martine, Lina
AU  - Bruno, Bal
AU  - Antonin, Josset
AU  - Laurence
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Evaluation of NGS-based approaches for SARS-CoV-2 whole genome characterisation
T2  - Virus Evolution
TI  - Evaluation of NGS-based approaches for SARS-CoV-2 whole genome characterisation
UR  - https://doi.org/10.1093/ve/veaa075
ID  - 7792893
ER  - 

TY  - JOUR
AB  - Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2 caused COVID-19 has reached a pandemic level. COVID-19 can significantly affect patients�?cardiovascular systems. First, those with COVID-19 and preexisting cardiovascular disease have an increased risk of severe disease and death. Mortality from COVID-19 is strongly associated with cardiovascular disease, diabetes, and hypertension. Second, therapies under investigation for COVID-19 may have cardiovascular side effects of arrhythmia. Third, COVID-19 is associated with multiple direct and indirect cardiovascular complications. Associated with a high inflammatory burden related to cytokine release, COVID-19 can induce vascular inflammation, acute myocardial injury, myocarditis, arrhythmias, venous thromboembolism, metabolic syndrome and Kawasaki disease. Understanding the effects of COVID-19 on the cardiovascular system is essential for providing comprehensive medical care for cardiac and/or COVID-19 patients. We hereby review the literature on COVID-19 regarding cardiovascular virus involvement.
AN  - PMC7536131
AU  - Chang, Wei-Ting
AU  - Toh, Han Siong
AU  - Liao, Chia-Te
AU  - Yu, Wen-Liang
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.amjms.2020.10.002
DP  - NLM
J2  - Am J Med Sci
KW  - coronavirus
COVID-19
SARS-CoV-2
myocardial injury
myocarditis
LA  - eng
N1  - PMC7536131[pmcid]
S0002-9629(20)30434-1[PII]
PY  - 2020
SN  - 0002-9629
1538-2990
ST  - Cardiac Involvement of COVID-19: A Comprehensive Review
T2  - American Journal of Medical Sciences
TI  - Cardiac Involvement of COVID-19: A Comprehensive Review
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536131/
ID  - 7790660
ER  - 

TY  - JOUR
AB  - With recent reports showing clinical and laboratory overlap of multisystem inflammatory syndrome in children and Kawasaki disease (KD), we addressed the hypothesis that cross coronavirus humoral immunity leads to a parallel postinfectious phenomenon explaining similar pathologic findings in KD and multisystem inflammatory syndrome in children. We demonstrated no cross-reactivity in children with KD but observed some nonspecific interactions postintravenous immunoglobulin infusion.
AD  - From the Department of Pediatrics, University at Buffalo, Buffalo, New York.
AN  - 33021596
AU  - Chang, A. J.
AU  - Croix, M.
AU  - Kenney, P.
AU  - Baron, S.
AU  - Hicar, M. D.
C1  - 10/7/2020
DA  - Aug 12
DB  - PubMed
DO  - 10.1097/inf.0000000000002863
DP  - NLM
ET  - 2020/10/07
J2  - The Pediatric infectious disease journal
LA  - eng
N1  - 1532-0987
Chang, Arthur J
Croix, Michael
Kenney, Patrick
Baron, Sarah
Hicar, Mark D
Journal Article
United States
Pediatr Infect Dis J. 2020 Aug 12. doi: 10.1097/INF.0000000000002863.
PY  - 2020
SN  - 0891-3668
ST  - SERUM RESPONSES OF CHILDREN WITH KAWASAKI DISEASE AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 PROTEINS
T2  - Pediatric infectious disease journal
TI  - SERUM RESPONSES OF CHILDREN WITH KAWASAKI DISEASE AGAINST SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2 PROTEINS
ID  - 7791018
ER  - 

TY  - JOUR
AU  - Cénat, Jude Mary
AU  - Dalexis, Rose Darly
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Complex Trauma Spectrum During the COVID-19 Pandemic: A Threat for Children and Adolescents�?Physical and Mental Health
T2  - Psychiatry Research
TI  - The Complex Trauma Spectrum During the COVID-19 Pandemic: A Threat for Children and Adolescents�?Physical and Mental Health
UR  - https://doi.org/10.1016/j.psychres.2020.113473
ID  - 7793074
ER  - 

TY  - JOUR
AB  - Community pharmacies have recently been asked to contribute to sustainable healthcare systems through active participation in an integrated model of care and by playing a major educational role for environmental conservation Therefore, dramatic changes in their institutional context have led to increasing competition in the drugs retail sector and a shift toward a service-oriented business These factors urge rethinking of the business model of these hybrid organizations, which combine a profit-oriented, social, and more recently addressed, environmental identity This paper aims at discussing a sustainable business model (SBM) that could allow community pharmacies to contribute to public health through pharmacists&amp;rsquo;current role and development of that role The effects of the COVID-19 pandemic suggest that human health should be at the center of the sustainable development agenda;the pandemic raises questions about the traditional role of community pharmacies, such as extending patient-oriented services The SBM for community pharmacies represents an opportunity to enhance their role among the healthcare workforce, especially in a time of global pandemics In addition, the SBM can support community pharmacies to integrate sustainability in day-to-day pharmacy practice, although it should be customized based on the contextual characteristics of the business and on differences between countries, such as health policies and regulations
AU  - Cavicchi, Caterina
AU  - Vagnoni, Emidia
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Sustainable Business Models in Hybrids: A Conceptual Framework for Community Pharmacies�?Business Owners
T2  - Sustainability
TI  - Sustainable Business Models in Hybrids: A Conceptual Framework for Community Pharmacies�?Business Owners
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813184
ID  - 7793368
ER  - 

TY  - JOUR
AB  - A rapid test for detecting total immunoglobulins directed towards the nucleocapsid protein (N) of severe acute syndrome coronavirus 2 (SARS CoV-2) was developed, based on a multi-target lateral flow immunoassay comprising two test lines Both test lines bound to several classes of immunoglobulins (G, M, and A) Specific anti-SARS immunoglobulins were revealed by a colorimetric probe formed by N and gold nanoparticles Targeting the total antibodies response to infection enabled achieving 100% diagnostic specificity (95 75-100, C I 95%, n=85 healthy and with other infections individuals) and 94 6% sensitivity (84 9-98 9, C I 95%, n= 62 SARS CoV-2 infected subjects) as early as 7 days post confirmation of positivity Agreeing results with a reference serological ELISA were achieved, except for the earlier detection capability of the rapid test Follow up of the three seroconverting patients endorsed the hypothesis of the random rise of the different immunoglobulins and strengthened the ‘total antibodies�?approach for the trustworthy detection of serological response to SARS CoV-2 infection
AU  - Cavalera, Simone
AU  - Colitti, Barbara
AU  - Rosati, Sergio
AU  - Ferrara, Gianmarco
AU  - Bertolotti, Luigi
AU  - Nogarol, Chiara
AU  - Guiotto, Cristina
AU  - Cagnazzo, Celeste
AU  - Denina, Marco
AU  - Fagioli, Franca
AU  - Di Nardo, Fabio
AU  - Chiarello, Matteo
AU  - Baggiani, Claudio
AU  - Anfossi, Laura
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A multi-target lateral flow immunoassay enabling the specific and sensitive detection of total antibodies to SARS COV-2
T2  - Talanta
TI  - A multi-target lateral flow immunoassay enabling the specific and sensitive detection of total antibodies to SARS COV-2
UR  - https://doi.org/10.1016/j.talanta.2020.121737
ID  - 7793047
ER  - 

TY  - JOUR
AU  - Castillo-Mart�Tnez, Maria
AU  - Castillo-Mart�Tnez, Marina
AU  - Ferrer, Marc
AU  - Gonz֙lez-Peris, Sebastià
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - DEPRESIÓN INFANTO-JUVENIL Y OTROS ASPECTOS DE SALUD MENTAL DURANTE EL CONFINAMIENTO Y LA PANDEMIA POR SARS-COV-2/COVID-19: ENCUESTA EN CONTEXTO ESCOLAR
T2  - Anales de Pediatr�Ta
TI  - DEPRESIÓN INFANTO-JUVENIL Y OTROS ASPECTOS DE SALUD MENTAL DURANTE EL CONFINAMIENTO Y LA PANDEMIA POR SARS-COV-2/COVID-19: ENCUESTA EN CONTEXTO ESCOLAR
UR  - https://doi.org/10.1016/j.anpedi.2020.09.013
ID  - 7793230
ER  - 

TY  - JOUR
AB  - In this period of Covid19 pandemic, for historians to create parallels with previous experiences in similar contexts becomes almost instantaneous. The Spanish Flu, which our grandparents still remember, was a disease that in the course of history killed millions of people: it is thought that at least 25-30 million people died from it, in Italy estimates show about 600,000 deaths for Spanish flu. The city of Milan, in particular the Policlinico Ca&#039; Granda, was overwhelmed by this disease. From September 1918 to April 1919, a total of 5,684 people suffering from Influenza were admitted to the hospital, of whom 4,198 recovered and 1,486 died. Between 1918 and 1919, administrative and organizational measures were imple- mented to deal with the situation. Initiatives were taken on the hygiene of the hospital environment and on the disinfection of the patients&#039; linen; numerous instruments were purchased; new spaces were opened for the Spanish patients and rules and procedures were introduced regarding visits to the sick by the public. We should not forget the central role that nurses played during 1918 and 1919. As today, several colleagues were affected and died for this cause, but they were awarded prizes, gratifications and praise for the hard and dangerous work they did on a daily basis.
AU  - Castiglioni di Caronno, Erica
AU  - La Torre, Anna
C1  - 10/7/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 2
LA  - it
PY  - 2020
SP  - 75-80
ST  - Vita al Policlinico di Milano durante l'influenza Spagnola. Una storia di corsi e ricorsi
T2  - Prof Inferm
TI  - Vita al Policlinico di Milano durante l'influenza Spagnola. Una storia di corsi e ricorsi
TT  - [Life at the Policlinico of Milan during the Spanish flu. A story of recurring cycles].
UR  - https://dx.doi.org/10.7429/pi.2020.732075
VL  - 73
ID  - 7793828
ER  - 

TY  - JOUR
AB  - Objectives To describe the clinical evolution and predictors of symptom persistence during 2-month follow-up in adults with non-critical COVID-19 Methods Descriptive clinical follow-up (days 7, 30 [D30] and 60 [D60]) of 150 patients with non-critical COVID-19 confirmed by RT-PCR at Tours University Hospital from March 17 to June 3, 2020, including demographic, clinical and laboratory data collected from the electronic medical records and by phone call Persisting symptoms were defined by the presence at D30 or D60 of at least one of the following: weight loss �?5%, severe dyspnea or asthenia, chest pain, palpitations, anosmia/ageusia, headache, cutaneous signs, arthralgia, myalgia, digestive disorders, fever or sick leave Results At D30, 68% (n=103/150) of patients presented at least one symptom and 66% (n=86/130) at D60, mainly anosmia/ageusia: (59% (n=89/150) at symptom onset, 28% (n=40/150) at D30 and 23% (n=29/130) at D60) Dyspnea concerned 36 7% (n=55/150) patients at D30 and 30% (n=39/130) at D60 Half of the patients (n=74/150) at D30 and 40% (n=52/130) at D60 reported asthenia Persistent symptoms at D60 were significantly associated with age 40 to 60 years old, hospital admission and abnormal auscultation at symptom onset At D30, severe COVID-19 and/or dyspnea at symptom onset were additional factors associated with persistent symptoms Conclusions Up to 2 months after symptom onset, two thirds of adults with non-critical COVID-19 had complaints, mainly anosmia/ageusia, dyspnea or asthenia A prolonged medical follow-up of patients with COVID-19 seems essential, whatever the initial clinical presentation
AU  - Carvalho-Schneider, Claudia
AU  - Laurent, Emeline
AU  - Lemaignen, Adrien
AU  - Beaufils, Emilie
AU  - Bourbao-Tournois, Céline Laribi
AU  - Saïd, Flament
AU  - Thomas, Ferreira-Maldent
AU  - Nicole, Bruy؈re Franck
AU  - Stefic, Karl
AU  - Gaudy-Graffin, Catherine
AU  - Grammatico-Guillon, Leslie
AU  - Bernard, Louis
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Follow-up of adults with non-critical COVID-19 two months after symptoms' onset
T2  - Clinical Microbiology and Infection
TI  - Follow-up of adults with non-critical COVID-19 two months after symptoms' onset
UR  - https://doi.org/10.1016/j.cmi.2020.09.052
ID  - 7793199
ER  - 

TY  - JOUR
AB  - The rise of the COVID-19 pandemic has exposed the incongruity of individualization ideologies that position individuals at the centre of health care, by contributing, making informed decisions and exercising choice regarding their health options and lifestyle considerations. When confronted with a global health threat, government across the world, have understood that the rhetoric of individualization, personal responsibility and personal choice would only led to disastrous national health consequences. In other words, individual choice offers a poor criterion to guide the health and wellbeing of a population. This reality has forced many advanced economies around the world to suspend their pledges to 'small government', individual responsibility and individual freedom, opting instead for a more rebalanced approach to economic and health outcomes with an increasing role for institutions and mutualization. For many marginalized communities, individualization ideologies and personalization approaches have never worked. On the contrary, they have exacerbated social and health inequalities by benefiting affluent individuals who possess the educational, cultural and economic resources required to exercise 'responsibility', avert risks and adopt health protecting behaviours. The individualization of the management of risk has also further stigmatized the poor by shifting the blame for poor health outcomes from government to individuals. This paper will explore how the COVID-19 pandemic exposes the cracks of neoliberal rhetoric on personalization and opens new opportunities to approach the health of a nation as socially, economically and politically determined requiring 'upstream' interventions on key areas of health including housing, employment, education and access to health care.
AD  - Centre for Primary Health Care and Equity, University of NSW, Sydney, Australia.
AN  - 33025018
AU  - Cardona, B.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1093/heapro/daaa112
DP  - NLM
ET  - 2020/10/08
J2  - Health promotion international
KW  - Australian social policy
health equity
social determinants of health
LA  - eng
N1  - 1460-2245
Cardona, Beatriz
Journal Article
England
Health Promot Int. 2020 Oct 7:daaa112. doi: 10.1093/heapro/daaa112.
PY  - 2020
SN  - 0957-4824
ST  - The pitfalls of personalization rhetoric in time of health crisis: COVID-19 pandemic and cracks on neoliberal ideologies
T2  - Health promotion international
TI  - The pitfalls of personalization rhetoric in time of health crisis: COVID-19 pandemic and cracks on neoliberal ideologies
ID  - 7790727
ER  - 

TY  - JOUR
AB  - The microbiota-gut-liver-lung axis plays a bidirectional role in the pathophysiology of a number of infectious diseases. During the course of severe acute respiratory syndrome coronavirus 1 (SARS-CoV-1) and 2 (SARS-CoV-2) infection, this pathway is unbalanced due to intestinal involvement and systemic inflammatory response. Moreover, there is convincing preliminary evidence linking microbiota-gut-liver axis perturbations, proinflammatory status, and endothelial damage in noncommunicable preventable diseases with coronavirus disease 2019 (Covid-19) severity. Intestinal damage due to SARS-CoV-2 infection, systemic inflammation-induced dysfunction, and IL-6-mediated diffuse vascular damage may increase intestinal permeability and precipitate bacterial translocation. The systemic release of damage- and pathogen-associated molecular patterns (e.g. lipopolysaccharides) and consequent immune-activation may in turn auto-fuel vicious cycles of systemic inflammation and tissue damage. Thus, intestinal bacterial translocation may play an additive/synergistic role in the cytokine release syndrome in Covid-19. This review provides evidence on gut-liver axis involvement in Covid-19 as well as insights into the hypothesis that intestinal endotheliitis and permeability changes with bacterial translocation are key pathophysiologic events modulating systemic inflammatory response. Moreover, it presents an overview of readily applicable measures for the modulation of the gut-liver axis and microbiota in clinical practice.
AD  - Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Viale dell'Università 37, Rome 00185, Italy. Electronic address: vincenzo.cardinale@uniroma1.it.
Pancreato-biliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milan, Italy.
Digestive Disease Center, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy.
Department of Translational and Precision Medicine, Sapienza University of Rome, Viale dell'Università 37, Rome 00185, Italy.
AN  - 33023827
AU  - Cardinale, V.
AU  - Capurso, G.
AU  - Ianiro, G.
AU  - Gasbarrini, A.
AU  - Arcidiacono, P. G.
AU  - Alvaro, D.
C1  - 10/7/2020
DA  - Sep 16
DB  - PubMed
DO  - 10.1016/j.dld.2020.09.009
DP  - NLM
ET  - 2020/10/08
J2  - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
KW  - Cytokine release syndrome
Gut-liver axis
Microbiota modulation
SARS-CoV-2 host response
LA  - eng
N1  - 1878-3562
Cardinale, Vincenzo
Capurso, Gabriele
Ianiro, Gianluca
Gasbarrini, Antonio
Arcidiacono, Paolo Giorgio
Alvaro, Domenico
Journal Article
Review
Netherlands
Dig Liver Dis. 2020 Sep 16:S1590-8658(20)30469-2. doi: 10.1016/j.dld.2020.09.009.
PY  - 2020
SN  - 1590-8658
ST  - Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis
T2  - Digestive and liver disease : official journal of Italian Society of Gastroenterology and Italian Association for Study of Liver
TI  - Intestinal permeability changes with bacterial translocation as key events modulating systemic host immune response to SARS-CoV-2: A working hypothesis
ID  - 7790876
ER  - 

TY  - JOUR
AB  - Middle East Respiratory Syndrome coronavirus (MERS-CoV) is a highly virulent pathogen that causes Middle East Respiratory Syndrome (MERS). Anti-MERS-CoV antibodies play an integral role in the prevention and treatment against MERS-CoV infections. Bioactivity is a key quality attribute of therapeutic antibodies, and high accuracy and precision are required. The major methods for evaluating the antiviral effect of antiviral antibodies include neutralization assays using live viruses or pseudoviruses are highly variable. Recent studies have demonstrated that the antibody-dependent cellular cytotoxicity (ADCC) activity of antiviral antibodies is more consistent with the virus clearance effect in vivo than neutralization activity. However, no reports evaluating the ADCC activity of anti-MERS antibodies have been published to date. Here, we describe the development of a robust and reliable cell-based reporter gene assay for the determination of ADCC activity of anti-MERS antibodies using 293T/MERS cells stably expressing the spike protein of MERS-CoV (MERS-S) as target cells and the engineered Jurkat/NFAT-luc/Fc��RIIIa stably expressing Fc��RIIIA and NFAT reporter gene as effector cells. According to the ICH-Q2 analytical method guidelines, we carefully optimized the experimental conditions and assessed the performance of our assay. In addition, we found that the ADCC activity of afucosylated anti-MERS antibodies is higher than their fucosylated counterparts. The establishment of this ADCC determination system provides a novel method for evaluating the bioactivity of anti-MERS antibodies and improving ADCC activity through modification of N-glycosylation of the Fc segment.
AD  - Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 31, Huotuo Road, Biomedical Base, Daxing District, Beijing, 102629, China.
Department of Physiology and Pathopysiology, Capital Medical University, Youanmen, Fengtai District, Beijing, 100069, China.
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Academy of Sciences, Beijing, 100101, China.
Department of Physiology and Pathopysiology, Capital Medical University, Youanmen, Fengtai District, Beijing, 100069, China. xmwang@ccmu.edu.cn.
Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech Products, National Institutes for Food and Drug Control, No. 31, Huotuo Road, Biomedical Base, Daxing District, Beijing, 102629, China. wangjz_nifdc2014@163.com.
AN  - 33024203
AU  - Cao, J.
AU  - Wang, L.
AU  - Yu, C.
AU  - Wang, K.
AU  - Wang, W.
AU  - Yan, J.
AU  - Li, Y.
AU  - Yang, Y.
AU  - Wang, X.
AU  - Wang, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73960-x
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Cao, Junxia
Wang, Lan
Yu, Chuanfei
Wang, Kaiqin
Wang, Wenbo
Yan, Jinghua
Li, Yan
Yang, Yalan
Wang, Xiaomin
Wang, Junzhi
2018ZX09736008-006/National Science and Technology Major Project/
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16615. doi: 10.1038/s41598-020-73960-x.
PY  - 2020
SN  - 2045-2322
SP  - 16615
ST  - Development of an antibody-dependent cellular cytotoxicity reporter assay for measuring anti-Middle East Respiratory Syndrome antibody bioactivity
T2  - Scientific reports
TI  - Development of an antibody-dependent cellular cytotoxicity reporter assay for measuring anti-Middle East Respiratory Syndrome antibody bioactivity
VL  - 10
ID  - 7790834
ER  - 

TY  - JOUR
AU  - Cao, Bin
AU  - Hayden, Frederick G.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Antiviral monotherapy for hospitalised patients with COVID-19 is not enough
T2  - Lancet
TI  - Antiviral monotherapy for hospitalised patients with COVID-19 is not enough
UR  - https://doi.org/10.1016/S0140-6736(20)32078-X
ID  - 7793022
ER  - 

TY  - JOUR
AB  - Issue Preparedness can be considered the Achilles heel in Western Coutries to adequately fight Sars-CoV-2 pandemy The Istituto Superiore di Sanità (ISS) has been challenged to give rapid technical and scientific advices to the State and Regions on a huge variety of Sars-CoV-2 aspects related to public health Description of the problem Rapid and timely accumulation of knowledge and empirical evidence is critical for policymakers and emergency managers to maximally inform their decisions through scientific evidence and to better guide and mobilise the expertise of academics and general practitioners towards effective solutions Results An ad hoc “Scientific Literature working group�?at ISS in the period 23/03 - 31/05 screened a total of 4,568 pre-prints and 15,590 peer reviewed papers extracted from PubMed, arXiv org, medRxiv and bioRxiv, which gave rise to the following deliverables: a) a daily pre-prints alert selection delivered to ISS President for the routine national Scientific Technical Committee meetings on Sars-CoV-2 chaired by Italian Civil Protection (still ongoing), and, b) a weekly open access issue of Covid Contents publications (8 volumes, https://www iss it/en/covid-contents), as summary of most interesting peer-reviewed papers for public health professions Lessons The needed cross-cutting approach is leading to: interdisciplinarity enhancement within the ISS;coverage of broad expertise areas and interest of health care providers;cross-linkage between the different aspects/disciplines involved in this pandemic and share of experiences Key messages Committed Institutions have the responsibility to support practitioners and decision makers to understand relevant aspects of medical, physical, occupational and public safety, in case of emergency The Silos culture has to be overcome There is nothing more powerful in any Institution than having all researchers rowing fiercely in the same direction
AU  - Caminada, S.
AU  - Angelozzi, A.
AU  - Barbaro, A.
AU  - Brambilla, G.
AU  - Carusi, D.
AU  - De Castro, P.
AU  - Gentili, D.
AU  - Mistretta, A.
AU  - Mochi, P.
AU  - Rosi, A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Rapid scientific update response to public health professions during Phase I of COVID-19 pandemic
T2  - European Journal of Public Health
TI  - Rapid scientific update response to public health professions during Phase I of COVID-19 pandemic
UR  - https://doi.org/10.1093/eurpub/ckaa165.355
ID  - 7792914
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has highlighted challenges inherent to serological detection of a novel pathogen like SARS-CoV-2. Serological tests can be used diagnostically and for surveillance, but their usefulness depends on throughput, sensitivity and specificity. Here, we describe a multiplex fluorescent microsphere-based assay, 3Flex, that can detect antibodies to three SARS-CoV-2 antigens-spike (S) protein, the spike ACE2 receptor-binding domain (RBD), and nucleocapsid (NP). Specificity was assessed using 213 pre-pandemic samples. Sensitivity was measured and compared to the Abbott�?ARCHITECT�?SARS-CoV-2 IgG assay using serum from 125 unique patients equally binned (n = 25) into 5 time intervals (�?, 6 to 10, 11 to 15, 16 to 20, and �?1 days from symptom onset). With samples obtained at �? days from symptom onset, the 3Flex assay was more sensitive (48.0% vs. 32.0%), but the two assays performed comparably using serum obtained �?1 days from symptom onset. A larger collection (n = 534) of discarded sera was profiled from patients (n = 140) whose COVID-19 course was characterized through chart review. This revealed the relative rise, peak (S, 23.8; RBD, 23.6; NP, 16.7; in days from symptom onset), and decline of the antibody response. Considerable interperson variation was observed with a subset of extensively sampled ICU patients. Using soluble ACE2, inhibition of antibody binding was demonstrated for S and RBD, and not for NP. Taken together, this study described the performance of an assay built on a flexible and high-throughput serological platform that proved adaptable to the emergence of a novel infectious agent.Competing Interest StatementS.A. is an employee of Luminex. N.P received some support for the purchase of reagents and supplies from Luminex. Luminex played no role in the design of the study, analysis of data, or writing of the manuscript.Funding StatementFunding from the Department of Pathology and Laboratory Medicine, University of Rochester Medical Center supported this study. This study was also partially supported by the National Institutes of Health Institute of Allergy, Immunology and Infectious Diseases grantsR21 AI138500 and R01 AI129518 (MZ, JW) and the University of Rochester Clinical and Translational Science Award UL1 TR002001 from the National Center for Advancing Translational Sciences of the National Institutes of Health (MZ). Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was approved by the URMC IRB.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll manuscript data is available as an attached data set.
AU  - Cameron, Andrew
AU  - Porterfield, Claire A.
AU  - Byron, Larry
AU  - Wang, Jiong
AU  - Pearson, Zachary
AU  - Bohrhunter, Jessica L.
AU  - Cardillo, Anthony B.
AU  - Ryan-Muntz, Lindsay
AU  - Sorensen, Ryan A.
AU  - Caserta, Mary
AU  - Angeloni, Steven
AU  - Hardy, Dwight J.
AU  - Zand, Martin
AU  - Pecora, Nicole Danielle
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20203976
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20203976
ST  - A multiplex microsphere IgG assay for SARS-CoV-2 using ACE2-mediated inhibition as a surrogate for neutralization (preprint)
T2  - medRxiv
TI  - A multiplex microsphere IgG assay for SARS-CoV-2 using ACE2-mediated inhibition as a surrogate for neutralization (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20203976.abstract
ID  - 7794754
ER  - 

TY  - JOUR
AB  - AIMS: Telehealth is being rapidly adopted by physical and occupational therapists in pediatrics as a strategy to maintain services during the COVID-19 crisis. This perspective presents a mix of theoretical and practice perspectives to support the implementation of telehealth. Although research evidence is just emerging, there is sufficient indication to believe telehealth is effective. However, which telehealth strategies are best for which children and families, and which intervention goals, are not yet clear. METHODS: We discuss how different telehealth strategies (e.g. videoconferencing, emails, phone calls, online programs) are being used to address specific intervention goals. Comments from therapists using telehealth and examples of practices in different context and with different populations are provided. We discuss how newly adopted telehealth practices could be included in future hybrid service delivery models and programs, as well as factors influencing the decision to offer face-to-face or online interventions. CONCLUSION: Although telehealth has been implemented quickly as a response to a health care crisis, and is not a one-size-fits-all intervention, we believe it offers great opportunities to increase the accessibility, cost-effectiveness and family-centredness of our services, to best support families of children with disabilities.
AD  - School of Rehabilitation, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Québec, Canada.
Rehabilitation Teaching & Research Unit (RTRU), Te Whare Whakāmatūtū, Department of Medicine, University of Otago, Wellington, New Zealand.
AN  - 33023352
AU  - Camden, C.
AU  - Silva, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/01942638.2020.1825032
DP  - NLM
ET  - 2020/10/08
J2  - Physical & occupational therapy in pediatrics
KW  - eHealth
pediatric
service delivery
telerehabilitationrehabilitation
LA  - eng
N1  - 1541-3144
Camden, Chantal
Silva, Mindy
Orcid: 0000-0003-0404-5284
Journal Article
England
Phys Occup Ther Pediatr. 2020 Oct 6:1-17. doi: 10.1080/01942638.2020.1825032.
PY  - 2020
SN  - 0194-2638
SP  - 1-17
ST  - Pediatric Teleheath: Opportunities Created by the COVID-19 and Suggestions to Sustain Its Use to Support Families of Children with Disabilities
T2  - Physical & occupational therapy in pediatrics
TI  - Pediatric Teleheath: Opportunities Created by the COVID-19 and Suggestions to Sustain Its Use to Support Families of Children with Disabilities
ID  - 7790916
ER  - 

TY  - JOUR
AB  - BACKGROUND: The utility of heated and humidified high-flow nasal oxygen (HFNO) for severe COVID-19-related hypoxaemic respiratory failure (HRF), particularly in s``ettings with limited access to intensive care unit (ICU) resources, remains unclear, and predictors of outcome have been poorly studied. METHODS: We included consecutive patients with COVID-19-related HRF treated with HFNO at two tertiary hospitals in Cape Town, South Africa. The primary outcome was the proportion of patients who were successfully weaned from HFNO, whilst failure comprised intubation or death on HFNO. FINDINGS: The median (IQR) arterial oxygen partial pressure to fraction inspired oxygen ratio (P(a)O2/FiO(2)) was 68 (54�?2) in 293 enroled patients. Of these, 137/293 (47%) of patients [P(a)O2/FiO(2) 76 (63�?3)] were successfully weaned from HFNO. The median duration of HFNO was 6 (3�?) in those successfully treated versus 2 (1�?) days in those who failed (p0.001). A higher ratio of oxygen saturation/FiO2 to respiratory rate within 6 h (ROX-6 score) after HFNO commencement was associated with HFNO success (ROX-6; AHR 0.43, 0.31�?.60), as was use of steroids (AHR 0.35, 95%CI 0.19�?.64). A ROX-6 score of �?.7 was 80% predictive of successful weaning whilst ROX-6 ≤�?.2 was 74% predictive of failure. In total, 139 patents (52%) survived to hospital discharge, whilst mortality amongst HFNO failures with outcomes was 129/140 (92%). INTERPRETATION: In a resource-constrained setting, HFNO for severe COVID-19 HRF is feasible and more almost half of those who receive it can be successfully weaned without the need for mechanical ventilation.
AN  - PMC7536126
AU  - Calligaro, Gregory L.
AU  - Lalla, Usha
AU  - Audley, Gordon
AU  - Gina, Phindile
AU  - Miller, Malcolm G.
AU  - Mendelson, Marc
AU  - Dlamini, Sipho
AU  - Wasserman, Sean
AU  - Meintjes, Graeme
AU  - Peter, Jonathan
AU  - Levin, Dion
AU  - Dave, Joel A.
AU  - Ntusi, Ntobeko
AU  - Meier, Stuart
AU  - Little, Francesca
AU  - Moodley, Desiree L.
AU  - Louw, Elizabeth H.
AU  - Nortje, Andre
AU  - Parker, Arifa
AU  - Taljaard, Jantjie J.
AU  - Allwood, Brian W.
AU  - Dheda, Keertan
AU  - Koegelenberg, Coenraad F. N.
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.eclinm.2020.100570
DP  - NLM
J2  - EClinicalMedicine
KW  - COVID-19
Ventilation
High flow nasal oxygen
Pneumonia
LA  - eng
N1  - PMC7536126[pmcid]
S2589-5370(20)30314-X[PII]
PY  - 2020
SN  - 2589-5370
SP  - 100570
ST  - The utility of high-flow nasal oxygen for severe COVID-19 pneumonia in a resource-constrained setting: A multi-centre prospective observational study: HFNO for COVID-19 pneumonia
T2  - EClinicalMedicine
TI  - The utility of high-flow nasal oxygen for severe COVID-19 pneumonia in a resource-constrained setting: A multi-centre prospective observational study: HFNO for COVID-19 pneumonia
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536126/
ID  - 7790673
ER  - 

TY  - JOUR
AB  - The coronavirus disease-2019 (COVID-19) pandemic is deeply impacting the accessibility of cancer patients to surgery. In resource-limited conditions, the standard of care might not be deliverable, but evidence to support alternative management strategies often exists. By revisiting available treatment options, this review provides surgical oncologists with an evidence-based framework for treating patients with gastrointestinal stromal tumor, extremity/truncal soft tissue sarcoma, and retroperitoneal sarcoma to rapidly adapt their decision-making to the constant evolution of the COVID-19 pandemic.
AD  - Department of Surgery, University of Toronto, Toronto, ON, Canada.
Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Department of Surgery, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.
Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
Department of Surgery, University of Washington, Seattle, Washington, USA.
Department of Radiation Oncology, Gustave Roussy, Villejuif, France.
Medical Oncology Department in University Hospital Virgen del Rocio and Institute of Biomedicine of Sevilla (IBIS) (HUVR, CSIC), University of Sevilla, Sevilla, Spain.
AN  - 33022754
AU  - Callegaro, D.
AU  - Raut, C. P.
AU  - Keung, E. Z.
AU  - Kim, T.
AU  - Le Pechoux, C.
AU  - Martin-Broto, J.
AU  - Gronchi, A.
AU  - Swallow, C.
AU  - Gladdy, R.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/jso.26246
DP  - NLM
ET  - 2020/10/07
J2  - Journal of surgical oncology
KW  - Covid-19
gastrointestinal stromal tumor
retroperitoneal sarcoma
sarcoma
soft tissue sarcoma
LA  - eng
N1  - 1096-9098
Callegaro, Dario
Orcid: 0000-0002-3392-4002
Raut, Chandrajit P
Orcid: 0000-0001-7297-3221
Keung, Emily Z
Orcid: 0000-0002-8783-8484
Kim, Teresa
Le Pechoux, Cecile
Martin-Broto, Javier
Gronchi, Alessandro
Swallow, Carol
Gladdy, Rebecca
Journal Article
Review
United States
J Surg Oncol. 2020 Oct 6. doi: 10.1002/jso.26246.
PY  - 2020
SN  - 0022-4790
ST  - Strategies for care of patients with gastrointestinal stromal tumor or soft tissue sarcoma during COVID-19 pandemic: A guide for surgical oncologists
T2  - Journal of surgical oncology
TI  - Strategies for care of patients with gastrointestinal stromal tumor or soft tissue sarcoma during COVID-19 pandemic: A guide for surgical oncologists
ID  - 7790949
ER  - 

TY  - JOUR
AB  - We measured severe acute respiratory syndrome coronavirus 2 spike protein subunits S1/S2 antibodies by using capillary electrophoresis and a chemiluminescence immunoassay for 5,444 active healthcare workers in Italy. Seroprevalence was 6.9% and higher among participants having contact with patients. Seroconversion was not observed in 37/213 previously infected participants.
AN  - 33021927
AU  - Calcagno, A.
AU  - Ghisetti, V.
AU  - Emanuele, T.
AU  - Trunfio, M.
AU  - Faraoni, S.
AU  - Boglione, L.
AU  - Burdino, E.
AU  - Audagnotto, S.
AU  - Lipani, F.
AU  - Nigra, M.
AU  - D'Avolio, A.
AU  - Bonora, S.
AU  - Di Perri, G.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.3201/eid2701.203027
DP  - NLM
ET  - 2020/10/07
IS  - 1
J2  - Emerging infectious diseases
KW  - Covid-19
Italy
SARS-CoV-2
Turin
age
coronavirus
coronavirus disease
healthcare workers
respiratory infections
risk
screening
seroprevalence
severe acute respiratory syndrome coronavirus 2
viruses
zoonoses
LA  - eng
N1  - 1080-6059
Calcagno, Andrea
Ghisetti, Valeria
Emanuele, Teresa
Trunfio, Mattia
Faraoni, Silvia
Boglione, Lucio
Burdino, Elisa
Audagnotto, Sabrina
Lipani, Filippo
Nigra, Marco
D'Avolio, Antonio
Bonora, Stefano
Di Perri, Giovanni
Journal Article
United States
Emerg Infect Dis. 2020 Oct 6;27(1). doi: 10.3201/eid2701.203027.
PY  - 2020
SN  - 1080-6040
ST  - Risk for SARS-CoV-2 Infection in Healthcare Workers, Turin, Italy
T2  - Emerging infectious diseases
TI  - Risk for SARS-CoV-2 Infection in Healthcare Workers, Turin, Italy
VL  - 27
ID  - 7790994
ER  - 

TY  - JOUR
AB  - OBJECTIVES: This study aims to explore the impacts of visibility and accessibility of alcohol gel-based hand sanitizer dispensers (HSDs) on healthcare workers&#039; hand-hygiene (HH) behaviors. BACKGROUND: Despite the importance of HH in reducing nosocomial infection, few empirical studies have quantitatively investigated the impacts of unit shape and size, and the resulted visibility and accessibility on HH, due to the lack of consistent methods to measure and evaluate visibility. METHODS: The research was developed as a cross-sectional comparative study of two nursing units (Units A and B) with similar patient acuity and nursing care model but different shape and layout. The study applied quantitative research methods including visibility and accessibility analysis using space syntax, 1-week on-site observation, and secondary data analysis on HH compliance rates. RESULTS: Results indicate that the unit with higher visibility and accessibility is associated with higher HH frequencies. Unit B has significantly higher visibility of HSDs, p &lt; .001, t(60) = 4.615, and significantly higher frequency of HH activity occurrences, 5.17% versus 1.52%; p &lt; .001, t(16.750) = 5.332, than Unit A, even though Unit B has lower HSD to bed ratio (0.708:1 vs. 1.375:1). The linear regression models also demonstrate that visibility and accessibility of HSDs are significant predictors of HH behavior. CONCLUSIONS: Overall, this exploratory study identified the importance of visibility of HSDs to improve the chances of HH. It also points out the impacts of nursing unit typology on the visibility of HSDs and in turn affects HH behavior.
AU  - Cai, Hui
AU  - Tyne, Intisar Ameen
AU  - Spreckelmeyer, Kent
AU  - Williams, Jennifer
C1  - 10/7/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - en
PY  - 2020
SP  - 1937586720962506-1937586720962506
ST  - Impact of Visibility and Accessibility on Healthcare Workers' Hand-Hygiene Behavior: A Comparative Case Study of Two Nursing Units in an Academic Medical Center
T2  - HERD
TI  - Impact of Visibility and Accessibility on Healthcare Workers' Hand-Hygiene Behavior: A Comparative Case Study of Two Nursing Units in an Academic Medical Center
UR  - https://dx.doi.org/10.1177/1937586720962506
ID  - 7793376
ER  - 

TY  - JOUR
AB  - Background: While COVID-19 remains largely unclear and mortality continues to raise, early effective approaches prior to complications lack, as well as researches for characterization and therapeutical potential options in actual early COVID-19. Although females seem to be less affected than females, hyperandrogenic (HA) phenotype, like polycystic ovary syndrome (PCOS), idiopathic hirsutism, congenital adrenal hyperplasia (CAH) female androgenetic alopecia (AGA), or idiopathic HA may be at higher risk due to its inherent enhanced androgenic activity. The present study aimed to evaluate the effects of any early pharmacological approach to females diagnosed with COVID-19 before seven days of symptoms, as well as investigate whether HA is an additional risk factor in this population. Materials and methods: Females with symptoms for less than seven days confirmed for COVID-19 through positive real-time polymerase chain reaction (rtPCR-SARS-CoV-2) were classified and divided as non-HA, HA, and HA using spironolactone (HA-spiro) groups. Patients were questioned for baseline characteristics, 23 different diseases, 44 drug classes and vaccines, 28 different symptoms, and eight different parameters to measure COVID-19 related clinical outcomes. Treatment was then provided, including azithromycin 500mg/day for five days in all cases, associated with hydroxychloroquine 400mg/day for five days, nitazoxanide 500mg twice a day for six days, or ivermectin 0.2mg/kg/day por three days, and optionally spironolactone 100mg twice a day until cure. Patients were assessed for COVID-19 clinical course, clinical and viral duration, and disease progression. Results: In total, 270 females were enrolled, including 195, 67, and eight in non-HA, HA, and HA-spiro groups, respectively. Prevailing symptoms were anosmia (71.1%), ageusia (67.0%), headache (48.1%), myalgia (37.4%), dry cough (36.3%), nasal congestion or rhinorrhea (34.1%), fatigue (33.3%), weakness (29.5%), hyporexia (27.8%), thoracic pain (24.8%), diarrhea (24.1%) and dizziness (21.5%). Earliest symptoms (days) were dizziness (1.0 +- 0.2 day), abdominal pain (1.1 +- 0.3); conjunctival hyperemia (1.1 +- 0.5), nasal congestion or rhinorrhea (1.2 +- 0.5), headache (1.2 +- 0.5), dry cough (1.2 +- 61617; 0.5), myalgia (1.2 +- 0.4), nauseas (1.3 +- 0.5) and weakness (1.3 +- 0.5). Time-to-treat, positive rtPCR, and duration of symptoms with and without anosmia and ageusia were significantly lower in HA-spiro than non-HA, HA, and overall non-users. Time-to-treat was similar while all duration of symptoms and positive rtPCR-SARS-CoV-2 were significantly shorter in non-HA than HA. Spironolactone users were more likely to be asymptomatic than non-users during COVID-19. Fewer non-HA than HA females were affected by anosmia, ageusia, dry cough, fatigue, weakness and hyporexia. Ageusia, weakness and myalgia lasted shorter in non-HA than HA. None of the patients needed hospitalization or any other COVID-19 complication. Conclusions: A sensitive, early detection of COVID-19 followed by a pharmaceutical approach with different drug combinations yielded irrefutable differences compared to sex-, age-, body mass index (BMI)-, and disease-matched non-treated controls in terms of clinical outcomes, ethically disallowing placebo-control randomized clinical trials in the early stage of COVID-19 due to the marked improvements. HA females presented more severe and prolonged clinical manifestations, although none progressed to worse outcomes. Spironolactone mitigated the additional risks due to HA.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT04446429Funding StatementThe funding of present study was fully supported by Corpometria Institute (Brasilia, DF, Brazil) and Applied Biology Inc (Irvine, CA, USA).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The present study has received approval from the Institutional Review Board (IRB) of the Ethics Committee of the National Board of Ethics Committee of the Ministry of Health, Brazil (CEP/CONEP: Parecer 4.173.074 / CAAE: 34110420.2.0000.0008).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesFull raw data is available at a data repository (https://osf.io/cm4f8/). https://osf.io/cm4f8/
AU  - Cadegiani, Flavio A.
AU  - Wambier, Carlos Gustavo
AU  - Goren, Andy
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206870
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206870
ST  - An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial (preprint)
T2  - medRxiv
TI  - An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206870.abstract
ID  - 7794777
ER  - 

TY  - JOUR
AU  - Caddell, A.
AU  - Belliveau, D.
AU  - Pottinger, L.
AU  - Moeller, A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - MULTIDISCIPLINARY SIMULATION TO ENHANCE SAFE CARE OF CRITICALLY ILL COVID-19 PATIENTS IN THE CORONARY CARE UNIT
T2  - Canadian Journal of Cardiology
TI  - MULTIDISCIPLINARY SIMULATION TO ENHANCE SAFE CARE OF CRITICALLY ILL COVID-19 PATIENTS IN THE CORONARY CARE UNIT
UR  - https://doi.org/10.1016/j.cjca.2020.07.237
ID  - 7793207
ER  - 

TY  - JOUR
AU  - Caban-Martinez, A. J.
AU  - Santiago, K. M.
AU  - Louzado-Feliciano, P.
AU  - Gonzalez, M.
AU  - Brotons, A.
AU  - Schaefer Solle, N.
AU  - Issenberg, S. B.
AU  - Kobetz-Kerman, E. N.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Influenza Vaccination Coverage and Sars-Cov-2 Seroprevalance in a Fire Department
T2  - Annals of Epidemiology
TI  - Influenza Vaccination Coverage and Sars-Cov-2 Seroprevalance in a Fire Department
UR  - https://doi.org/10.1016/j.annepidem.2020.08.058
ID  - 7793231
ER  - 

TY  - JOUR
AB  - Comorbid conditions appear to be common among individuals hospitalised with coronavirus disease 2019 (COVID-19) but estimates of prevalence vary and little is known about the prior medication use of patients. Here, we describe the characteristics of adults hospitalised with COVID-19 and compare them with influenza patients. We include 34,128 (US: 8362, South Korea: 7341, Spain: 18,425) COVID-19 patients, summarising between 4811 and 11,643 unique aggregate characteristics. COVID-19 patients have been majority male in the US and Spain, but predominantly female in South Korea. Age profiles vary across data sources. Compared to 84,585 individuals hospitalised with influenza in 2014-19, COVID-19 patients have more typically been male, younger, and with fewer comorbidities and lower medication use. While protecting groups vulnerable to influenza is likely a useful starting point in the response to COVID-19, strategies will likely need to be broadened to reflect the particular characteristics of individuals being hospitalised with COVID-19.
AD  - Fundaci�Q Institut Universitari per a la recerca a l'Atenci�Q Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain.
Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDROMS), University of Oxford, Oxford, UK.
Department of Biomedical Informatics, Ajou University School of Medicine, Suwon, Korea.
Janssen Research and Development, Titusville, NJ, USA.
Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Real World Solutions, IQVIA, Cambridge, MA, USA.
Eli Lilly and Company, Indianapolis, IN, USA.
Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Observational Health Data Sciences and Informatics Network, Alberta, Canada.
Faculty of Medicine, Islamic University of Gaza, Gaza, Palestine.
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Medication Safety Research Chair, King Saud University, Riyadh, Saudi Arabia.
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Department of Computer Science, Georgia State University, Atlanta, GA, USA.
Data Science, Dana-Farber Cancer Institute. Biostatistics, Harvard TH Chan School of Public Health, Boston, MA, USA.
Odysseus Data Services, Inc., Cambridge, MA, USA.
Department for Microbiology, Virology and Immunology, Belarusian State Medical University, Minsk, Belarus.
Department of Veterans Affairs, Salt Lake City, UT, USA.
University of Utah School of Medicine, Salt Lake City, UT, USA.
Department of Biomedical Informatics, Columbia University, New York, NY, USA.
Health Economics and Outcomes Research, AbbVie, North Chicago, IL, USA.
Pharmacoepidemiology, Regeneron, NY, USA.
Department of Epidemiology, Johns Hopkins School of Public, Baltimore, MD, USA.
New York-Presbyterian Hospital, New York, NY, USA.
National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.
Department of Biomedical Sciences, Ajou University Graduate School of Medicine, Suwon, Korea.
Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, Daegu Catholic University Medical Center, Daegu, Korea.
Clinical Pharmacology Unit, Zealand University Hospital, Køge, Denmark.
NNF Centre for Protein Research, University of Copenhagen, København, Denmark.
Department of Pediatrics �?2, V. N. Karazin Kharkiv National University, Kharkiv, Ukraine.
Science Policy and Research, National Institute for Health and Care Excellence, London, UK.
Department of Orthopaedic Surgery, College of Medicine, Hanyang University, Seoul, Korea.
Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDROMS), University of Oxford, Oxford, UK.
Bigdata Department, Health Insurance Review & Assessment Service, Wonju, Korea.
GRECC, Tennessee Valley Healthcare System VA, Nashville, TN, USA.
Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
College of Medicine-Tucson, University of Arizona, Tucson, AZ, USA.
Division of Population Health and Genomics, University of Dundee, Dundee, UK.
School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Medicine, School of Medicine, Stanford University, Stanford, CA, USA.
Data Science to Patient Value Program, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Department of Biostatistics, UCLA Fielding School of Public Health, University of California, Los Angeles, CA, USA.
Department of Anesthesiology and Pain Medicine, Catholic University of Daegu, School of Medicine, Gyeongsan, Korea.
Bayer Pharmaceuticals, Barcelona, Spain.
Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Tufts Institute for Clinical Research and Health Policy Studies, Boston, MA, USA.
Centre for Epidemiology Versus Arthritis, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.
School of Public Health, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China.
Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Centre for Statistics in Medicine (CSM), Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDROMS), University of Oxford, Oxford, UK. daniel.prietoalhambra@ndorms.ox.ac.uk.
Columbia University, New York, NY, USA.
AN  - 33024121
AU  - Burn, E.
AU  - You, S. C.
AU  - Sena, A. G.
AU  - Kostka, K.
AU  - Abedtash, H.
AU  - Abrahão, M. T. F.
AU  - Alberga, A.
AU  - Alghoul, H.
AU  - Alser, O.
AU  - Alshammari, T. M.
AU  - Aragon, M.
AU  - Areia, C.
AU  - Banda, J. M.
AU  - Cho, J.
AU  - Culhane, A. C.
AU  - Davydov, A.
AU  - DeFalco, F. J.
AU  - Duarte-Salles, T.
AU  - DuVall, S.
AU  - Falconer, T.
AU  - Fernandez-Bertolin, S.
AU  - Gao, W.
AU  - Golozar, A.
AU  - Hardin, J.
AU  - Hripcsak, G.
AU  - Huser, V.
AU  - Jeon, H.
AU  - Jing, Y.
AU  - Jung, C. Y.
AU  - Kaas-Hansen, B. S.
AU  - Kaduk, D.
AU  - Kent, S.
AU  - Kim, Y.
AU  - Kolovos, S.
AU  - Lane, J. C. E.
AU  - Lee, H.
AU  - Lynch, K. E.
AU  - Makadia, R.
AU  - Matheny, M. E.
AU  - Mehta, P. P.
AU  - Morales, D. R.
AU  - Natarajan, K.
AU  - Nyberg, F.
AU  - Ostropolets, A.
AU  - Park, R. W.
AU  - Park, J.
AU  - Posada, J. D.
AU  - Prats-Uribe, A.
AU  - Rao, G.
AU  - Reich, C.
AU  - Rho, Y.
AU  - Rijnbeek, P.
AU  - Schilling, L. M.
AU  - Schuemie, M.
AU  - Shah, N. H.
AU  - Shoaibi, A.
AU  - Song, S.
AU  - Spotnitz, M.
AU  - Suchard, M. A.
AU  - Swerdel, J. N.
AU  - Vizcaya, D.
AU  - Volpe, S.
AU  - Wen, H.
AU  - Williams, A. E.
AU  - Yimer, B. B.
AU  - Zhang, L.
AU  - Zhuk, O.
AU  - Prieto-Alhambra, D.
AU  - Ryan, P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41467-020-18849-z
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Nature communications
LA  - eng
N1  - 2041-1723
Burn, Edward
Orcid: 0000-0002-9286-1128
You, Seng Chan
Orcid: 0000-0002-5052-6399
Sena, Anthony G
Kostka, Kristin
Orcid: 0000-0003-2595-8736
Abedtash, Hamed
Orcid: 0000-0002-9139-5452
Abrahão, Maria Tereza F
Orcid: 0000-0003-2701-670x
Alberga, Amanda
Alghoul, Heba
Orcid: 0000-0001-8234-5843
Alser, Osaid
Orcid: 0000-0001-6743-803x
Alshammari, Thamir M
Aragon, Maria
Areia, Carlos
Orcid: 0000-0002-4668-7069
Banda, Juan M
Orcid: 0000-0001-8499-824x
Cho, Jaehyeong
Culhane, Aedin C
Orcid: 0000-0002-1395-9734
Davydov, Alexander
DeFalco, Frank J
Duarte-Salles, Talita
DuVall, Scott
Falconer, Thomas
Fernandez-Bertolin, Sergio
Gao, Weihua
Golozar, Asieh
Orcid: 0000-0002-4243-155x
Hardin, Jill
Hripcsak, George
Huser, Vojtech
Jeon, Hokyun
Orcid: 0000-0002-6220-4207
Jing, Yonghua
Jung, Chi Young
Kaas-Hansen, Benjamin Skov
Orcid: 0000-0003-1023-0371
Kaduk, Denys
Kent, Seamus
Kim, Yeesuk
Orcid: 0000-0003-4956-0693
Kolovos, Spyros
Lane, Jennifer C E
Orcid: 0000-0002-1729-8654
Lee, Hyejin
Lynch, Kristine E
Makadia, Rupa
Matheny, Michael E
Mehta, Paras P
Orcid: 0000-0002-0233-9871
Morales, Daniel R
Natarajan, Karthik
Orcid: 0000-0002-9066-9431
Nyberg, Fredrik
Orcid: 0000-0003-0892-5668
Ostropolets, Anna
Park, Rae Woong
Park, Jimyung
Orcid: 0000-0002-6998-2546
Posada, Jose D
Orcid: 0000-0003-3864-0241
Prats-Uribe, Albert
Orcid: 0000-0003-1202-9153
Rao, Gowtham
Reich, Christian
Rho, Yeunsook
Rijnbeek, Peter
Schilling, Lisa M
Schuemie, Martijn
Shah, Nigam H
Orcid: 0000-0001-9385-7158
Shoaibi, Azza
Song, Seokyoung
Orcid: 0000-0002-5653-7005
Spotnitz, Matthew
Suchard, Marc A
Orcid: 0000-0001-9818-479x
Swerdel, Joel N
Vizcaya, David
Orcid: 0000-0003-0248-7636
Volpe, Salvatore
Wen, Haini
Williams, Andrew E
Orcid: 0000-0002-0692-412x
Yimer, Belay B
Orcid: 0000-0001-8621-6539
Zhang, Lin
Orcid: 0000-0002-2064-8440
Zhuk, Oleg
Prieto-Alhambra, Daniel
Orcid: 0000-0002-3950-6346
Ryan, Patrick
806968/Innovative Medicines Initiative (IMI)/
Journal Article
England
Nat Commun. 2020 Oct 6;11(1):5009. doi: 10.1038/s41467-020-18849-z.
PY  - 2020
SN  - 2041-1723
SP  - 5009
ST  - Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
T2  - Nature communications
TI  - Deep phenotyping of 34,128 adult patients hospitalised with COVID-19 in an international network study
VL  - 11
ID  - 7790839
ER  - 

TY  - JOUR
AB  - and full-text screening according to pre-defined eligibility criteria were performed by two reviewers independently using web application Rayyan QCRI. Disagreements on study selection were resolved by a third reviewer. The systematic review protocol was registered in PROSPERO (CRD42020200641). Results: Neither published nor pre-print studies evaluating the use of chlorine dioxide or derivatives on SARS-CoV-2 infection were identified. The only finding was an unpublished observational study registry which has no results released yet. Conclusions: To date, there are no scientific evidence to uphold the use of chlorine dioxide or derivatives as preventive or therapeutic agents against COVID-19. (English) [ABSTRACT FROM AUTHOR]
Objetivos: Realizar una revisi�Qn sistem֙tica acerca de la efectividad y seguridad del uso de di�Qxido de cloro y derivados del cloro, en la prevenci�Qn o el tratamiento de la COVID-19. Materiales y métodos: Se siguieron las pautas internacionales de elaboraci�Qn de revisiones sistem֙ticas de PRISMA y el Manual Cochrane para revisiones sistem֙ticas de intervenciones. La estrategia de búsqueda la desarroll�Q un bibliotecario y la revisaron dos de los autores. Se complement�Q la búsqueda electr�Qnica con una búsqueda manual. Se incluyeron ensayos cl�Tnicos aleatorizados, estudios cuasiexperimentales, estudios de cohorte, estudios de casos y controles, estudios de corte transversal y reportes de casos; y se excluyeron estudios in vitro o realizados en animales. Dos revisores, de forma independiente, seleccionaron los estudios según los criterios de elegibilidad definidos, usando el aplicativo web Rayyan, en caso de discordancia se hizo part�Tcipe a un tercer revisor. El protocolo de la revisi�Qn sistem֙tica se registr�Q en PROSPERO (CRD42020200641). Resultados: No se identific�Q ningún estudio publicado ni en proceso de publicaci�Qn que haya evaluado el uso del di�Qxido de cloro o derivados del cloro, administrado por v�Ta inhalatoria, oral o parenteral en humanos, como agente preventivo o terapéutico de la COVID-19 o en infecciones por otros coronavirus. Solo se identific�Q el registro de un único estudio catalogado como observacional que hasta ahora no tiene resultados. Conclusiones: A la fecha, no existe evidencia cient�Tfica que apoye el uso del di�Qxido de cloro o derivados del cloro para prevenir o tratar la COVID-19. (Spanish) [ABSTRACT FROM AUTHOR]
Copyright of Revista Peruana de Medicina Experimental y Salud Pública is the property of Instituto Nacional de Salud (Peru) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146241522
AU  - Burela, Alejandra
AU  - Hern֙ndez-V֙squez, Akram
AU  - Comandé, Daniel
AU  - Peralta, Ver�Qnica
AU  - Fiestas, Fabian
C1  - 10/7/2020
DB  - a9h
DO  - 10.17843/rpmesp.2020.374.6330
DP  - EBSCOhost
IS  - 4
KW  - Chlorine Compounds
Chlorine Dioxide
Prevention and Control
SARS-CoV-2 infection
Severe Acute Respiratory Syndrome Coronavirus 2
Compuestos de Cloro
COVID-19
Di�Qxido de Cloro
Infecci�Qn por SARS-CoV-2
Prevenci�Qn y Control
S�Tndrome Respiratorio Agudo Grave Coronavirus 2
M3  - Article
N1  - Burela, Alejandra 1 Hern֙ndez-V֙squez, Akram 1 Comandé, Daniel 2 Peralta, Ver�Qnica 1; Email Address: veronica.peralta@essalud.gob.pe Fiestas, Fabian 1; Affiliation: 1: Instituto de Evaluaci�Qn de Tecnolog�Tas en Salud e Investigaci�Qn - IETSI, EsSalud, Lima, Perú 2: Instituto de Efectividad Cl�Tnica y Sanitaria (IECS), Buenos Aires, Argentina; Source Info: 2020, Vol. 37 Issue 4, p195; Author-Supplied Keyword: Chlorine Compounds; Author-Supplied Keyword: Chlorine Dioxide; Author-Supplied Keyword: Prevention and Control; Author-Supplied Keyword: SARS-CoV-2 infection; Author-Supplied Keyword: Severe Acute Respiratory Syndrome Coronavirus 2; Author-Supplied Keyword: Compuestos de Cloro; Author-Supplied Keyword: COVID-19; Author-Supplied Keyword: Di�Qxido de Cloro; Author-Supplied Keyword: Infecci�Qn por SARS-CoV-2; Author-Supplied Keyword: Prevenci�Qn y Control; Author-Supplied Keyword: S�Tndrome Respiratorio Agudo Grave Coronavirus 2; Language of Keywords: English; Language of Keywords: Spanish; Number of Pages: 6p; Document Type: Article; Language: Spanish
PY  - 2020
SN  - 17264634
SP  - 195-200
ST  - DIÓXIDO DE CLORO Y DERIVADOS DEL CLORO PARA PREVENIR O TRATAR LA COVID-19: REVISIÓN SISTEMÁTICA
T2  - Revista Peruana de Medicina Experimental y Salud Pública
TI  - DIÓXIDO DE CLORO Y DERIVADOS DEL CLORO PARA PREVENIR O TRATAR LA COVID-19: REVISIÓN SISTEMÁTICA
TT  - CHLORINE DIOXIDE AND CHLORINE DERIVATIVES FOR PREVENTION OR TREATMENT OF COVID-19: A SYSTEMATIC REVIEW.
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146241522&site=ehost-live
VL  - 37
ID  - 7789378
ER  - 

TY  - JOUR
AB  - This study aims to describe the impact of COVID-19 on internship activities at health organizations in Saudi Arabia. The study is a secondary analysis of data set that was collected from 101 health science interns from different health organizations. The majority of interns were trained or started their internships at public health organizations (64.29%), while 6.12% and 29.59% were at private and other health organizations, respectively. During the COVID-19 pandemic, most health organizations chose to continue the internships (76.53%), while others (23.47%) decided to suspend trainings. Health organizations have taken different actions to overcome the internship issues during the COVID-19 pandemic.
AD  - School of Public Health, College of Health Sciences, Saudi Electronic University, Dammam, Saudi Arabia.
AN  - 33021464
AU  - Bugis, B. A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/00185868.2020.1826894
DP  - NLM
ET  - 2020/10/07
J2  - Hospital topics
KW  - Health organization
health sciences
internship
organizational behavior
pandemic
LA  - eng
N1  - 1939-9278
Bugis, Bussma Ahmed
Orcid: 0000-0002-6123-8552
Journal Article
United States
Hosp Top. 2020 Oct 6:1-7. doi: 10.1080/00185868.2020.1826894.
PY  - 2020
SN  - 0018-5868
SP  - 1-7
ST  - The Impact of the COVID-19 Pandemic on Internship Activities at Health Organizations in Saudi Arabia
T2  - Hospital topics
TI  - The Impact of the COVID-19 Pandemic on Internship Activities at Health Organizations in Saudi Arabia
ID  - 7791028
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic and the resulting travel restrictions and fall in consumer demand led to a dramatic and unprecedented reduction in passenger flights across Europe As borders closed, national Governments advised against all but essential travel and passenger demand disappeared, European airlines were forced to quickly respond to the downturn and impose unprecedented cost saving measures to protect their business The aim of this paper is to examine the ways in which major European passenger airlines responded to the height of the COVID-19 crisis in the period March �?May 2020 Using data from Eurocontrol, the European network manager, the paper identifies the responses individual airline operators and parent companies took to contract and consolidate their operations The findings show that changes to flight operations, rationalising the fleet, reducing staff numbers, and reconfiguring their networks and capacity were the most common responses The paper concludes by discussing future considerations for airline business and management as European carriers seek to restructure their operations and adapt to a new post-COVID reality
AU  - Budd, Lucy
AU  - Ison, Stephen
AU  - Adrienne, Nena
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - European airline response to the COVID-19 pandemic �?Contraction, consolidation and future considerations for airline business and management
T2  - Research in Transportation Business & Management
TI  - European airline response to the COVID-19 pandemic �?Contraction, consolidation and future considerations for airline business and management
UR  - https://doi.org/10.1016/j.rtbm.2020.100578
ID  - 7793058
ER  - 

TY  - JOUR
AB  - SUMMARY COVID-19 is a systemic infection that exerts significant impact on the metabolism Yet, there is little information on how SARS-CoV-2 affects metabolism Using NMR spectroscopy, we measured the metabolomic and lipidomic serum profile from 263 (training cohort) + 135 (validation cohort) symptomatic patients hospitalized after positive PCR testing for SARS-CoV-2 infection We also established the profiles of 280 persons collected before the coronavirus pandemic started PCA analyses discriminated both cohorts, highlighting the impact that the infection has in overall metabolism The lipidomic analysis unraveled a pathogenic redistribution of the lipoprotein particle size and composition to increase the atherosclerotic risk In turn, metabolomic analysis reveals abnormally high levels of ketone bodies (acetoacetic acid, 3-hydroxybutyric acid and acetone) and 2-hydroxybutyric acid, a readout of hepatic glutathione synthesis and marker of oxidative stress Our results are consistent with a model in which SARS-CoV-2 infection induces liver damage associated with dyslipidemia and oxidative stress
AU  - Bruzzone, Chiara
AU  - Bizkarguenaga, Maider
AU  - Gil-Redondo, Rubén Diercks
AU  - Tammo, Arana
AU  - Eunate, Garc�Ta de Vicuña Aitor
AU  - Seco, Marisa
AU  - Bosch, Alexandre
AU  - Palaz�Qn, As�Ts San Juan
AU  - Itxaso, La�Tn Ana
AU  - Gil-Mart�Tnez, Jon
AU  - Bernardo-Seisdedos, Ganeko
AU  - Fern֙ndez-Ramos, David
AU  - Lopitz-Otsoa, Fernando
AU  - Embade, Nieves
AU  - Lu, Shelly
AU  - Mato, José M.
AU  - Millet, Oscar
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum
T2  - iScience
TI  - SARS-CoV-2 infection dysregulates the metabolomic and lipidomic profiles of serum
UR  - https://doi.org/10.1016/j.isci.2020.101645
ID  - 7793147
ER  - 

TY  - JOUR
AB  - The potential aerosolised transmission of severe acute respiratory syndrome coronavirus-2 is of global concern. Airborne precaution personal protective equipment and preventative measures are universally mandated for medical procedures deemed to be aerosol-generating. The implementation of these measures is having a huge impact on healthcare provision. There is currently a lack of quantitative evidence on the number and size of airborne particles produced during aerosol-generating procedures to inform risk assessments. To address this evidence gap, we conducted real-time, high-resolution environmental monitoring in ultraclean ventilation operating theatres during tracheal intubation and extubation sequences. Continuous sampling with an optical particle sizer allowed characterisation of aerosol generation within the zone between the patient and anaesthetist. Aerosol monitoring showed a very low background particle count (0.4 particles.l(-1) ) allowing resolution of transient increases in airborne particles associated with airway management. A positive reference control quantitated the aerosol produced in the same setting by a volitional cough (average concentration, 732 (418) particles.l(-1) , n = 38). Tracheal intubation including face-mask ventilation produced very low quantities of aerosolised particles (average concentration, 1.4 (1.4) particles.l(-1) , n = 14, p  0·0001 vs. cough). Tracheal extubation, particularly when the patient coughed, produced a detectable aerosol (21 (18) l(-1) , n = 10) which was 15-fold greater than intubation (p = 0.0004) but 35-fold less than a volitional cough (p  0.0001). The study does not support the designation of elective tracheal intubation as an aerosol-generating procedure. Extubation generates more detectable aerosol than intubation but falls below the current criterion for designation as a high risk aerosol-generating procedure. These novel findings from real-time aerosol detection in a routine healthcare setting provide a quantitative methodology for risk assessment that can be extended to other airway management techniques and clinical settings. They also indicate the need for reappraisal of what constitutes an aerosol-generating procedure and the associated precautions for routine anaesthetic airway management.
AD  - Department of Anaesthesia and Intensive Care Medicine, North Bristol NHS Trust, Bristol, UK.
School of Chemistry, University of Bristol, Bristol, UK.
School of Physiology, Pharmacology and Neuroscience, University of Bristol, Bristol, UK.
Consultant, Department of Anaesthesia and Intensive Care Medicine, Royal United Hospital NHS Trust, Bath, UK.
AN  - 33022093
AU  - Brown, J.
AU  - Gregson, F. K. A.
AU  - Shrimpton, A.
AU  - Cook, T. M.
AU  - Bzdek, B. R.
AU  - Reid, J. P.
AU  - Pickering, A. E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/anae.15292
DP  - NLM
ET  - 2020/10/07
J2  - Anaesthesia
KW  - Covid-19
Sars-cov-2
aerosol-generating procedure
extubation
intubation
LA  - eng
N1  - 1365-2044
Brown, J
Gregson, F K A
Shrimpton, A
Cook, T M
Bzdek, B R
Reid, J P
Pickering, A E
Journal Article
England
Anaesthesia. 2020 Oct 6. doi: 10.1111/anae.15292.
PY  - 2020
SN  - 0003-2409
ST  - A quantitative evaluation of aerosol generation during tracheal intubation and extubation
T2  - Anaesthesia
TI  - A quantitative evaluation of aerosol generation during tracheal intubation and extubation
ID  - 7790981
ER  - 

TY  - JOUR
AB  - Objectives: Care for older adults with cancer became more challenging during the COVID-19 pandemic We sought to examine cancer care providers&#039; attitudes toward the barriers and facilitators related to the care for these patients during the pandemic Materials and Methods: Members of the Advocacy Committee of the Cancer and Aging Research Group, along with the Association of Community Cancer Centers, developed the survey distributed to multidisciplinary healthcare providers responsible for the direct care of patients with cancer Participants were recruited by email sent through four professional organizations&#039; listservs, email blasts, and messages through social media Results: Complete data was available from 274 respondents Only 15 4% had access to written guidelines that specifically address the management of older adults with cancer during the COVID-19 pandemic Age was ranked fifth as the reason for postponing treatment following comorbid conditions, cancer stage, frailty, and performance status Barriers to the transition to telehealth were found at the patient-, healthcare worker-, and institutional-levels Providers reported increased barriers in accessing basic needs among older adults with cancer Most respondents agreed (86 3%) that decision making about Do Not Resuscitate orders should be the result of discussion with the patient and the healthcare proxy in all situations The top five concerns reported were related to patient safety, treatment delays, healthcare worker mental health and burnout, and personal safety for family and self Conclusion: These findings demand resources and support allocation for older adults with cancer and healthcare providers during the COVID-19 pandemic
AU  - BrintzenhofeSzoc, Karlynn
AU  - Krok-Schoen, Jessica I.
AU  - Pisegna, Janell L.
AU  - MacKenzie, Amy R.
AU  - Canin, Beverly
AU  - Plotkin, Elana
AU  - Boehmer, Leigh M.
AU  - Shahrokni, Armin
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Survey of cancer care providers' attitude toward care for older adults with cancer during the COVID-19 pandemic
T2  - Journal of Geriatric Oncology
TI  - Survey of cancer care providers' attitude toward care for older adults with cancer during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.jgo.2020.09.028
ID  - 7793132
ER  - 

TY  - JOUR
AB  - I write these words in early June in the northeastern United States Incongruously, the sun is shining, birds are chirping, and flowers bloom This apparent paradise is at odds with the two pandemics gripping this nation and the world at large: coronavirus disease (COVID-19) and racism Recent weeks and months have seen a string of horrifying events, one after another The brutal police violence that took the lives of Breonna Taylor and George Floyd and the vigilante murder of Ahmaud Arbery may seem to have little to do with the novel coronavirus that has killed over 400,000 people as of this writing However, these traumatic, disastrous outcomes are linked by the overarching and systemic racism that affects Black Americans and people of
AU  - Bright, Charlotte Lyn
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Two Pandemics
T2  - Social Work Research
TI  - The Two Pandemics
UR  - https://doi.org/10.1093/swr/svaa012
ID  - 7792894
ER  - 

TY  - JOUR
AB  - The pandemic will likely trigger a wave of claims and litigation Lawsuits are already being filed in response to institutional and conference decisions not to play sports in the fall and the cancellations of sponsorship arrangements Disputes over transmission of COVID-19 during practice and competition are likely right around the corner Unlike a workers? compensation system established as the exclusive remedy to compensate employees for work-related illnesses and injuries, college athletics doesn&#039;t offer a compensation system for student-athletes who contract the virus
AU  - Brien, Timothy
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Reduce liability in potential COVID-19-transmission cases
T2  - College Athletics and Law
TI  - Reduce liability in potential COVID-19-transmission cases
UR  - https://doi.org/10.1002/catl.30783
ID  - 7793318
ER  - 

TY  - JOUR
AD  - St George's University Hospitals NHS Foundation Trust, London SW17 0QT, UK.
AN  - 33023873
AU  - Breathnach, A. S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/bmj.m3880
DP  - NLM
ET  - 2020/10/08
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Breathnach, Aodhan S
Editorial
England
BMJ. 2020 Oct 6;371:m3880. doi: 10.1136/bmj.m3880.
PY  - 2020
SN  - 0959-8138
SP  - m3880
ST  - Covid-19 elimination: should we force our young to sacrifice their freedoms so the older generation can live a bit longer?
T2  - BMJ
TI  - Covid-19 elimination: should we force our young to sacrifice their freedoms so the older generation can live a bit longer?
VL  - 371
ID  - 7790871
ER  - 

TY  - JOUR
AB  - Objective: To assess the impact of the COVID-19 pandemic on families with young children in two population-based childhood cohorts with a low and moderate COVID-19 prevalence, respectively. Methods: A cross-sectional study using online questionnaires in families from LIFE Child (n=306, Leipzig) and KUNO Kids (n=612, Regensburg) was performed at the end of the German lock-down period. Outcomes were parent-reported impact of the COVID-19 pandemic on family life, concerns and trust in political measures. Results: Most families were concerned about the COVID-19 pandemic and lock-down measures, with major concerns directed towards the economic situation (&amp;gt;70%), the health of close-ones (37%), but less towards their own health (&amp;lt;10%). Many concerns, seeking information and approval of federal measures were more pronounced in the more affected region. Approval of lockdown measures and concerns about economic recession were related to regional differences and not significantly dependent on educational status or being personally affected by the disease. Conclusion: Regional differences in approval of lockdown measures were observed and thus, measures to specifically support families according to the regional impact of the COVID-19 pandemic are needed.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT02550236Funding StatementThe LIFE Child study is funded by means of the European Union, by means of the European Social Fund (ESF), by the European Regional Development Fund (ERDF), and by means of the Free State of Saxony as per the budget approved by the state parliament. The KUNO-Kids study is funded by research grants of the EU (HEALS: 603946) and the German Federal Ministry for Education and Research (SYSINFLAME: 01ZX1306E). Further financial support was provided by the University Children&#039;s Hospital Regensburg (KUNO) and the hospital St. Hedwig of the order of St. John.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The LIFE Child study was approved by the Ethics Committe of the Medical Faculty of the University of Leipzig (Reg. No. 264/10-ek). The KUNO-Kids study was approved by the Ethics Committee of the University of Regensburg (Reference Number 14-101-0347).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData Availability Statement: Data cannot be shared publicly because there exist ethical restrictions. The LIFE Child and KUNO Kids are a study collecting potentially sensitive information. Publishing data sets is not covered by the informed consent provided by the study participants. Furthermore, the data protection concept of LIFE requests that all (external as well as internal) researchers interested in accessing data sign a project agreement. Researchers that are interested in accessing and analyzing data collected in the LIFE Child study may contact the data use and access committee (dm@life.uni-leipzig.de). Researchers that are interested in accessing and analyzing data collected in the KUNO Kids study may contact the first author (Susanne.Brandstetter@barmherzige-regensburg.de).
AU  - Branstetter, Susanne
AU  - Poulain, Tanja
AU  - Vogel, Mandy
AU  - Meigen, Christof
AU  - Melter, Michael
AU  - Seelbach-Goebel, Birgit
AU  - Apfelbacher, Christian
AU  - Kiess, Wieland
AU  - Kabesch, Michael
AU  - Koerner, Antje
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206805
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206805
ST  - The impact of the COVID-19 pandemic on families in Germany (preprint)
T2  - medRxiv
TI  - The impact of the COVID-19 pandemic on families in Germany (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206805.abstract
ID  - 7794737
ER  - 

TY  - JOUR
AU  - Bozorgmehr, Kayvan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Power of and power over COVID-19 response guidelines
T2  - Lancet
TI  - Power of and power over COVID-19 response guidelines
UR  - https://doi.org/10.1016/S0140-6736(20)32081-X
ID  - 7793020
ER  - 

TY  - JOUR
AD  - B2S Life Sciences llc, 97 East Monroe Street, Franklin, Indiana, 46131, USA. Ron.Bowsher@B2SLifeSciences.com.
GlaxoSmithKline, 1250 South Collegeville Road, Collegeville, Pennsylvania, 19426, USA.
University of Illinois at Chicago, 1200 W. Harrison Street, Chicago, Illinois, 60607, USA.
AN  - 33025311
AU  - Bowsher, R. R.
AU  - Devanarayan, V.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1208/s12248-020-00510-8
DP  - NLM
ET  - 2020/10/08
IS  - 6
J2  - The AAPS journal
KW  - Covid-19
cut point
diagnostics
immunogenicity
serology
statistics
LA  - eng
N1  - 1550-7416
Bowsher, Ronald R
Devanarayan, Viswanath
Journal Article
United States
AAPS J. 2020 Oct 6;22(6):127. doi: 10.1208/s12248-020-00510-8.
PY  - 2020
SN  - 1550-7416
SP  - 127
ST  - Are Lessons Learned in Setting Cut Points for Detection of Anti-Drug Antibodies Also Useful in Serology Assays for Robust Detection of SARS-CoV-2 Reactive Antibodies?
T2  - AAPS journal
TI  - Are Lessons Learned in Setting Cut Points for Detection of Anti-Drug Antibodies Also Useful in Serology Assays for Robust Detection of SARS-CoV-2 Reactive Antibodies?
VL  - 22
ID  - 7790713
ER  - 

TY  - JOUR
AD  - Department of Paediatric Rheumatology, Reference Centre for Autoinflammatory Diseases and Amyloidosis (CEREMAIA), Bic�^tre University Hospital, AP-HP, Le Kremlin-Bicetre, France.
University of Paris Sud Saclay, Paris, France.
General Pediatrics, Infectious Disease and Internal Medicine Department, Reference center for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Hôpital Robert Debre, AP-HP, Paris, 75019, France.
Center for Research on Inflammation, UMR1149, INSERM, Paris, France.
UMR 1123, ECEVE, INSERM, Paris, France.
General Pediatrics, Infectious Disease and Internal Medicine Department, Reference center for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Hôpital Robert Debre, AP-HP, Paris, 75019, France isabelle.melki@aphp.fr.
Laboratory of Neurogenetics and Neuroinflammation, Institute Imagine Institute of Genetic Diseases, Paris, France.
Pediatric Hematology-Immunology and Rheumatology Department, Reference center for Rheumatic, AutoImmune and Systemic diseases in children (RAISE), Hôpital Necker-Enfants Malades, AP-HP, Paris, France.
AN  - 33023959
AU  - Borocco, C.
AU  - Pouletty, M.
AU  - Galeotti, C.
AU  - Meinzer, U.
AU  - Faye, A.
AU  - Koné-Paut, I.
AU  - Ouldali, N.
AU  - Melki, I.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/annrheumdis-2020-218814
DP  - NLM
ET  - 2020/10/08
J2  - Annals of the rheumatic diseases
KW  - epidemiology
immune complex diseases
inflammation
LA  - eng
N1  - 1468-2060
Borocco, Charlotte
Pouletty, Marie
Galeotti, Caroline
Meinzer, Ulrich
Faye, Albert
Koné-Paut, Isabelle
Orcid: 0000-0001-8939-5763
Ouldali, Naim
Melki, Isabelle
Orcid: 0000-0002-8057-333x
Journal Article
England
Ann Rheum Dis. 2020 Oct 6:annrheumdis-2020-218814. doi: 10.1136/annrheumdis-2020-218814.
PY  - 2020
SN  - 0003-4967
ST  - Response to 'Correspondence on 'Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID19): a multicentre cohort'' by Mastrolia et al
T2  - Annals of rheumatic diseases
TI  - Response to 'Correspondence on 'Paediatric multisystem inflammatory syndrome temporally associated with SARS-CoV-2 mimicking Kawasaki disease (Kawa-COVID19): a multicentre cohort'' by Mastrolia et al
ID  - 7790858
ER  - 

TY  - JOUR
AU  - Bornstein, E.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Maintaining Patient Connections with Online Support Groups
T2  - Oncology Issues
TI  - Maintaining Patient Connections with Online Support Groups
UR  - https://doi.org/10.1080/10463356.2020.1796095
ID  - 7792971
ER  - 

TY  - JOUR
AD  - Neurophysiologie respiratoire expérimentale et clinique, UMRS1158, INSERM, Sorbonne Université, Paris, France. v.bonny@hotmail.fr.
Service de Pneumologie, Médecine intensive Réanimation, Groupe Hospitalier Pitié-Salp�^tri؈re, 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France. v.bonny@hotmail.fr.
LIMICS, UMR_S, UPMC Univ Paris 06, INSERM, Sorbonne Paris Cité, Université Paris 13, Sorbonne Universités, 1142, Paris, France.
Bioserenity, Paris, France.
Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy.
Anaesthesia and Intensive Care Unit, Sant'Anna Hospital, Aldo Moro, Ferrara, Italy.
Neurophysiologie respiratoire expérimentale et clinique, UMRS1158, INSERM, Sorbonne Université, Paris, France.
Service de Pneumologie, Médecine intensive Réanimation, Groupe Hospitalier Pitié-Salp�^tri؈re, 47-83 boulevard de l'Hôpital, 75651, Paris Cedex 13, France.
Médecine Intensive-Réanimation (Département "R3S"), Service de Pneumologie, AP-HP, Hôpital Pitié-Salp�^tri؈re, Sorbonne Université, F-75013, Paris, France.
AN  - 33023638
AU  - Bonny, V.
AU  - Janiak, V.
AU  - Spadaro, S.
AU  - Pinna, A.
AU  - Demoule, A.
AU  - Dres, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13054-020-03311-9
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Critical care (London, England)
LA  - eng
N1  - 1466-609x
Bonny, Vincent
Janiak, Vincent
Spadaro, Savino
Pinna, Andrea
Demoule, Alexandre
Dres, Martin
Journal Article
England
Crit Care. 2020 Oct 6;24(1):596. doi: 10.1186/s13054-020-03311-9.
PY  - 2020
SN  - 1364-8535
SP  - 596
ST  - Effect of PEEP decremental on respiratory mechanics, gasses exchanges, pulmonary regional ventilation, and hemodynamics in patients with SARS-Cov-2-associated acute respiratory distress syndrome
T2  - Critical care (London, England)
TI  - Effect of PEEP decremental on respiratory mechanics, gasses exchanges, pulmonary regional ventilation, and hemodynamics in patients with SARS-Cov-2-associated acute respiratory distress syndrome
VL  - 24
ID  - 7790896
ER  - 

TY  - JOUR
AB  - A large component of many disease states is the improper regulation of immune function. This commonly leads to the appearance of redundant inflammation which does not effectively address any underlying issue but actually impedes a successful response to disease-induced metabolic derangement. There is currently no means of successfully addressing this problem which is especially relevant in the ongoing viral pandemic of SARS-CoV-2. In view of this failure, new courses of action need to be contemplated. This review proposes reconsideration of the potential utility of natural compounds originating from plants in order to address this deficit. Such a new direction, in concert with more conventional strategies could help to alleviate this wide-ranging crisis.
AD  - Center for Occupational and Environmental Health, University of California, Irvine, CA 92697, USA.
Engage Global, San Rafael, CA 94903, USA.
AN  - 33023332
AU  - Bondy, S. C.
AU  - Wu, M.
AU  - Prasad, K. N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/1535370220960690
DP  - NLM
ET  - 2020/10/08
J2  - Experimental biology and medicine (Maywood, N.J.)
KW  - Inflammation
SARS-CoV-2 virus
inflammatory cytokines
oxidative stress
signaling pathways
LA  - eng
N1  - 1535-3699
Bondy, Stephen C
Orcid: 0000-0001-5158-2993
Wu, Meixia
Prasad, Kedar N
Orcid: 0000-0001-5128-0063
Journal Article
England
Exp Biol Med (Maywood). 2020 Oct 6:1535370220960690. doi: 10.1177/1535370220960690.
PY  - 2020
SN  - 1535-3699
SP  - 1535370220960690
ST  - Attenuation of acute and chronic inflammation using compounds derived from plants
T2  - Experimental biology and medicine (Maywood, NJ)
TI  - Attenuation of acute and chronic inflammation using compounds derived from plants
ID  - 7790920
ER  - 

TY  - JOUR
AB  - Over the last months, due to coronavirus disease (COVID-19) pandemic, containment measures have led to important social restriction. Healthcare systems have faced a complete rearrangement of resources and spaces, with the creation of wards devoted to COVID-19 patients. In this context, patients affected by chronic neurological diseases, such as amyotrophic lateral sclerosis (ALS), are at risk to be lost at follow-up, leading to a higher risk of morbidity and mortality. Telemedicine may allow meet the needs of these patients. In this commentary, we briefly discuss the digital tools to remotely monitor and manage ALS patients. Focusing on detecting disease progression and preventing life-threatening conditions, we propose a toolset able to improve ALS management during this unprecedented situation.
AD  - "Rita Levi Montalcini" Department of Neuroscience, University of Torino, Turin, Italy.
Department of Advanced Medical and Surgical Sciences, II Clinic of Neurology, University of Campania "Luigi Vanvitelli", Naples, Italy. gianmarcoabbadessa@live.com.
Digital Technologies, Web and Social Media Study Group of the Italian Society of Neurology, Via Pansini 5, 80131, Naples, Italy. gianmarcoabbadessa@live.com.
Department of Advanced Medical and Surgical Sciences, I Clinic of Neurology, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Neurorehabilitation, IRCCS San Raffaele Hospital, Milan, Italy.
University Vita-Salute San Raffaele, Milan, Italy.
Department of Advanced Medical and Surgical Sciences, II Clinic of Neurology, University of Campania "Luigi Vanvitelli", Naples, Italy.
Department of Advanced Medical and Surgical Sciences, I Clinic of Neurology, University of Campania "Luigi Vanvitelli", Naples, Italy. Luigilavorgna@policliniconapoli.it.
AN  - 33025327
AU  - Bombaci, A.
AU  - Abbadessa, G.
AU  - Trojsi, F.
AU  - Leocani, L.
AU  - Bonavita, S.
AU  - Lavorgna, L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s10072-020-04783-x
DP  - NLM
ET  - 2020/10/08
J2  - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
KW  - ALS patients
Covid-19
Remote monitoring
Tele-health
Telemedicine
Teleneurology
LA  - eng
N1  - 1590-3478
Bombaci, Alessandro
Abbadessa, Gianmarco
Orcid: 0000-0001-8912-3055
Trojsi, Francesca
Leocani, Letizia
Bonavita, Simona
Lavorgna, Luigi
Digital Technologies, Web and Social Media Study Group of the Italian Society of Neurology
Journal Article
Review
Italy
Neurol Sci. 2020 Oct 6. doi: 10.1007/s10072-020-04783-x.
PY  - 2020
SN  - 1590-1874
ST  - Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail
T2  - Neurological sciences : official journal of Italian Neurological Society and of Italian Society of Clinical Neurophysiology
TI  - Telemedicine for management of patients with amyotrophic lateral sclerosis through COVID-19 tail
ID  - 7790711
ER  - 

TY  - JOUR
AB  - Frauds and misconduct have been common in the history of science. Recent events connected to the COVID-19 pandemic have highlighted how the risks and consequences of this are no longer acceptable. Two papers, addressing the treatment of COVID-19, have been published in two of the most prestigious medical journals; the authors declared to have analysed electronic health records from a private corporation, which apparently collected data of tens of thousands of patients, coming from hundreds of hospitals. Both papers have been retracted a few weeks later. When such events happen, the confidence of the population in scientific research is likely to be weakened. This paper highlights how the current system endangers the reliability of scientific research, and the very foundations of the trust system on which modern healthcare is based. Having shed light on the dangers of a system without appropriate monitoring, the proposed analysis suggests to strengthen the existing journal policies and improve the research process using new technologies supporting control activities by public authorities. Among these solutions, we mention the promising aspects of the blockchain technology which seems a promising solution to avoid the repetition of the mistakes linked to the recent and past history of research.
AD  - Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy davide.golinelli@unibo.it.
Department of Italian and Supranational Public Law, University of Milan, Milano, Lombardia, Italy.
AN  - 33023976
AU  - Boetto, E.
AU  - Golinelli, D.
AU  - Carullo, G.
AU  - Fantini, M. P.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/medethics-2020-106639
DP  - NLM
ET  - 2020/10/08
J2  - Journal of medical ethics
KW  - professional misconduct
public health ethics
publication ethics
research ethics
scientific research
LA  - eng
N1  - 1473-4257
Boetto, Erik
Golinelli, Davide
Orcid: 0000-0001-7331-9520
Carullo, Gherardo
Fantini, Maria Pia
Journal Article
England
J Med Ethics. 2020 Oct 6:medethics-2020-106639. doi: 10.1136/medethics-2020-106639.
PY  - 2020
SN  - 0306-6800
ST  - Frauds in scientific research and how to possibly overcome them
T2  - Journal of medical ethics
TI  - Frauds in scientific research and how to possibly overcome them
ID  - 7790856
ER  - 

TY  - JOUR
AB  - COVID-19 and the restrictive measures towards containing the spread of its infections have seriously affected the agricultural workforce and jeopardized food security The present study aims at assessing the COVID-19 pandemic impacts on agricultural labor and suggesting strategies to mitigate them To this end, after an introduction to the pandemic background, the negative consequences on agriculture and the existing mitigation policies, risks to the agricultural workers were benchmarked across the United States&amp;rsquo;Standard Occupational Classification system The individual tasks associated with each occupation in agricultural production were evaluated on the basis of potential COVID-19 infection risk As criteria, the most prevalent virus transmission mechanisms were considered, namely the possibility of touching contaminated surfaces and the close proximity of workers The higher risk occupations within the sector were identified, which facilitates the allocation of worker protection resources to the occupations where they are most needed In particular, the results demonstrated that 50% of the agricultural workforce and 54% of the workers&amp;rsquo;annual income are at moderate to high risk As a consequence, a series of control measures need to be adopted so as to enhance the resilience and sustainability of the sector as well as protect farmers including physical distancing, hygiene practices, and personal protection equipment
AU  - Bochtis, Dionysis
AU  - Benos, Lefteris
AU  - Lampridi, Maria
AU  - Marinoudi, Vasso
AU  - Pearson, Simon
AU  - Sørensen, Claus G.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Agricultural Workforce Crisis in Light of the COVID-19 Pandemic
T2  - Sustainability
TI  - Agricultural Workforce Crisis in Light of the COVID-19 Pandemic
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813179
ID  - 7793370
ER  - 

TY  - JOUR
AB  - PURPOSE: To assess the magnitude of the infection in residents from-and staff working in-a long-term-care facility (LTCF) 7 days after the identification of one resident with confirmed COVID-19 infection and to assess the clinical presentation of the infected residents. METHODS: All residents and staff members of a LTCF were tested for SARS-CoV-2 by real-time reverse-transcriptase polymerase chain reaction on nasopharyngeal swab. Residents were studied clinically 4 weeks after the first COVID diagnosis. RESULTS: Thirty-eight of the 79 residents (48.1%) tested positive for SARS-CoV-2. Respiratory symptoms were preceded by diarrhea (26.3%), a fall (18.4%), fluctuating temperature with hypothermia (34.2%) and delirium in one resident. Respiratory symptoms, including cough and oxygen desaturation, appeared after those initial symptoms or as the first sign in 36.8% and 52.2%, respectively. At any time of the disease, fever was observed in 65.8%. Twelve deaths occurred among the COVID-19 residents. Among the 41 residents negative for SARS-CoV-2, symptoms included cough (21.9%), diarrhea (7.3%), fever (21.9%), hypothermia (9.7%), and transient hypoxemia (9.8%). No deaths were observed in this group. 27.5% of the workers were also COVID-19 positive. CONCLUSION: The rapid dissemination of the COVID-19 infection may be explained by the delay in the diagnosis of the first cases due to atypical presentation. Early recognition of symptoms compatible with COVID-19 may help to diagnose COVID-19 residents earlier and test for SARS-CoV-2 symptomatic and asymptomatic staff and residents earlier to implement appropriate infection control practices.
AD  - Department of Geriatrics, Centre Antonin Balmes, Pôle de Gérontologie du Centre Hospitalier Universitaire de Montpellier, Montpellier University Hospital, Montpellier University, 39 Avenue Charles Flahault, 34295, Montpellier Cedex 5, France. h-blain@chu-montpellier.fr.
Gérontopôle de Toulouse, INSERM 1027, 31059, Toulouse, France.
Department of Geriatrics, CHRU de Nancy and Inserm DCAC, Université de Lorraine, Nancy, France.
Department of Geriatrics, Centre Antonin Balmes, Pôle de Gérontologie du Centre Hospitalier Universitaire de Montpellier, Montpellier University Hospital, Montpellier University, 39 Avenue Charles Flahault, 34295, Montpellier Cedex 5, France.
Department of Dermatology and Allergy, Berlin Institute of Health, Comprehensive Allergy Center, Charité, Universitätsmedizin Berlin, Humboldt-Universität zu Berlin, Berlin, Germany.
AN  - 33025500
AU  - Blain, H.
AU  - Rolland, Y.
AU  - Benetos, A.
AU  - Giacosa, N.
AU  - Albrand, M.
AU  - Miot, S.
AU  - Bousquet, J.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s41999-020-00352-9
DP  - NLM
ET  - 2020/10/08
J2  - European geriatric medicine
KW  - Covid-19
Long-term-care facility
Testing for SARS-CoV-2
rRT-PCR
LA  - eng
N1  - Blain, Hubert
Rolland, Yves
Benetos, Athanase
Giacosa, Nadia
Albrand, Myl؈ne
Miot, Stéphanie
Bousquet, Jean
Journal Article
Switzerland
Eur Geriatr Med. 2020 Oct 6. doi: 10.1007/s41999-020-00352-9.
PY  - 2020
SN  - 1878-7649 (Print)
1878-7649
ST  - Atypical clinical presentation of COVID-19 infection in residents of a long-term care facility
T2  - European geriatric medicine
TI  - Atypical clinical presentation of COVID-19 infection in residents of a long-term care facility
ID  - 7790703
ER  - 

TY  - JOUR
AD  - Northern Health, 185 Cooper Street, Epping, VIC, Australia, 3076.
AN  - 33022106
AU  - Birch, B.
AU  - Luo, Y.
AU  - Dhir, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/ans.16387
DP  - NLM
ET  - 2020/10/07
J2  - ANZ journal of surgery
KW  - Covid-19
airborne droplet contamination
laparoscopy
pneumoperitoneum
LA  - eng
N1  - 1445-2197
Birch, Benjamin
Luo, Yuchen
Orcid: 0000-0002-9269-9001
Dhir, Arun
Journal Article
Australia
ANZ J Surg. 2020 Oct 6. doi: 10.1111/ans.16387.
PY  - 2020
SN  - 1445-1433
ST  - How to minimise airborne droplet contamination while performing laparoscopy in the COVID-19 era
T2  - ANZ journal of surgery
TI  - How to minimise airborne droplet contamination while performing laparoscopy in the COVID-19 era
ID  - 7790980
ER  - 

TY  - JOUR
AN  - 33024331
AU  - Bingham, K.
C1  - 10/7/2020
DA  - Oct
DB  - PubMed
DO  - 10.1038/d41586-020-02798-0
DP  - NLM
ET  - 2020/10/08
IS  - 7828
J2  - Nature
KW  - Institutions
SARS-CoV-2
Vaccines
LA  - eng
N1  - 1476-4687
Bingham, Kate
News
England
Nature. 2020 Oct;586(7828):171. doi: 10.1038/d41586-020-02798-0.
PY  - 2020
SN  - 0028-0836
SP  - 171
ST  - Plan now to speed vaccine supply for future pandemics
T2  - Nature
TI  - Plan now to speed vaccine supply for future pandemics
VL  - 586
ID  - 7790824
ER  - 

TY  - JOUR
AD  - Cardiology Clinical Academic Group, St. George's, University of London, St. George's University Hospitals NHS Foundation Trust.
National Heart and Lung Institute, Imperial College London; and.
Royal Brompton & Harefield NHS Foundation Trust.
AN  - 33021673
AU  - Bhatia, R. T.
AU  - Gati, S.
AU  - Papadakis, M.
AU  - Sharma, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/eurheartj/ehaa742
DP  - NLM
ET  - 2020/10/07
J2  - European heart journal
LA  - eng
N1  - 1522-9645
Bhatia, Raghav T
Gati, Sabiha
Papadakis, Michael
Sharma, Sanjay
Journal Article
England
Eur Heart J. 2020 Oct 6:ehaa742. doi: 10.1093/eurheartj/ehaa742.
PY  - 2020
SN  - 0195-668x
ST  - The Impact of COVID-19 on the Continuity of Cardiovascular Care
T2  - European heart journal
TI  - The Impact of COVID-19 on the Continuity of Cardiovascular Care
ID  - 7791014
ER  - 

TY  - JOUR
AB  - The Veneto region is one of the most affected Italian regions by COVID-19. Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD), may constitute a risk factor in COVID-19. Moreover, respiratory viruses were generally associated with severe pulmonary impairment in cystic fibrosis (CF). We would have therefore expected numerous cases of severe COVID-19 among the CF population. Surprisingly, we found that CF patients were significantly protected against infection by SARS-CoV-2. We discussed this aspect formulating some reasonable theories.
AD  - Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata, 37126, Verona, Italy.
Cystic Fibrosis Center of Verona, Azienda Ospedaliera Universitaria Integrata, 37126, Verona, Italy. marco.cipolli@aovr.veneto.it.
AN  - 33023602
AU  - Bezzerri, V.
AU  - Lucca, F.
AU  - Volpi, S.
AU  - Cipolli, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s13052-020-00909-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Italian journal of pediatrics
KW  - Azythromycin
Covid-19
Cystic fibrosis
DNase
SARS-CoV-2
LA  - eng
N1  - 1824-7288
Bezzerri, Valentino
Lucca, Francesca
Volpi, Sonia
Cipolli, Marco
Orcid: 0000-0001-5652-7248
Letter
England
Ital J Pediatr. 2020 Oct 6;46(1):143. doi: 10.1186/s13052-020-00909-1.
PY  - 2020
SN  - 1720-8424
SP  - 143
ST  - Does cystic fibrosis constitute an advantage in COVID-19 infection?
T2  - Italian journal of pediatrics
TI  - Does cystic fibrosis constitute an advantage in COVID-19 infection?
VL  - 46
ID  - 7790901
ER  - 

TY  - JOUR
AB  - Argentina was able to anticipate public health interventions in order to flatten the contagion curve of CoViD-19. Eighty-three surgeons answered an online survey to assess the impact of the pandemic on bariatric surgery (BS) in Argentina. Most of them showed a high economic dependence on BS. Near 90% of health institutions were on phase 0 or I. While 90% still performed other laparoscopic surgeries, BS was suspended. In many surgeries for nonsuspected CoViD-19 patients, high personnel protection resources were applied. Ninety-five percent offered virtual consults. Most surgeons would not change usual algorithms or techniques. To restart BS a scientific society recommendation was expected, including patient selection criteria. The opinions gathered by this survey were taken into account to elaborate official recommendations for restarting elective BS.
AD  - Bariatric Surgery at Hospital Italiano de Buenos Aires, Ciudad Aut�Qnoma de Buenos Aires, Argentina. axel.beskow@hospitalitaliano.org.ar.
Argentine Society for the Surgery of Obesity (SACO), Bolivar 3585, Mar del Plata, B7600GEA, Argentina. axel.beskow@hospitalitaliano.org.ar.
Argentine Society for the Surgery of Obesity (SACO), Bolivar 3585, Mar del Plata, B7600GEA, Argentina.
Bariatric Surgery at Hospital Universitario Austral, Buenos Aires, Argentina.
Medical Director of New Life Center, Bariatric Surgery Institute, Guatemala City, Guatemala.
Bariatric Surgery at Hospital Privado de Comunidad, Mar del Plata, Buenos Aires, Argentina.
Gastro-Obeso-Center Institute of Metabolic Optimization, Sao Paulo, Brazil.
AN  - 33025540
AU  - Beskow, A. F.
AU  - Martinez-Duartez, P. R.
AU  - Behrens Estrada, E. J.
AU  - Fiolo, F. E.
AU  - Ramos, A. C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s11695-020-05004-2
DP  - NLM
ET  - 2020/10/08
J2  - Obesity surgery
KW  - Bariatric surgery
CoViD-19 pandemic
Personal protective equipment
Public health regulations
SARS-CoV2
LA  - eng
N1  - 1708-0428
Beskow, Axel F
Orcid: 0000-0003-2363-3823
Martinez-Duartez, Pedro R
Behrens Estrada, Estuardo J
Fiolo, Felipe E
Ramos, Almino C
Journal Article
United States
Obes Surg. 2020 Oct 6. doi: 10.1007/s11695-020-05004-2.
PY  - 2020
SN  - 0960-8923
ST  - CoViD-19 Pandemic and Bariatric Surgery in Argentina
T2  - Obesity surgery
TI  - CoViD-19 Pandemic and Bariatric Surgery in Argentina
ID  - 7790696
ER  - 

TY  - JOUR
AB  - COVID-19 disparities prompt Medicare to call for stronger emphasis on value-based care.
AN  - 33023286
AU  - Berlin, J.
C1  - 10/7/2020
DA  - Sep 1
DB  - PubMed
DP  - NLM
ET  - 2020/10/08
IS  - 9
J2  - Texas medicine
LA  - eng
N1  - 1938-3223
Berlin, Joey
Journal Article
United States
Tex Med. 2020 Sep 1;116(9):24-29.
PY  - 2020
SN  - 0040-4470
SP  - 24-29
ST  - A Social Shift: COVID-19 Disparities Prompt Emphasis on Value-Based Care
T2  - Texas medicine
TI  - A Social Shift: COVID-19 Disparities Prompt Emphasis on Value-Based Care
VL  - 116
ID  - 7790923
ER  - 

TY  - JOUR
AB  - Background The COVID-19 pandemic and related social distancing public health recommendations will have indirect consequences for individuals with current and remitted substance use disorder (SUD) Not only will stressors increase risk for symptom exacerbation and/or relapse, but individuals will also have limited service access during this critical time Individuals with SUD are using free, online digital recovery support services (D-RSS) that leverage social engagement (i e , social-online D-RSS) and simultaneously help these individuals to access support and adhere to public health guidelines Barriers to SUD treatment and recovery support service access, however, are not unique to the COVID-19 epoch The pandemic creates an opportunity to highlight problems that will persist beyond its immediate effects, and offer potential solutions that might help to address these long-standing, systemic issues To help providers and other key stakeholders effectively support those interested in, or who might benefit from, participation in free, social-online D-RSS, we review the expected therapeutic benefits and potential drawbacks of social-online D-RSS;we provide a typology to describe the array of services that a D-RSS can provide;and we discuss a D-RSS “case study�?to illustrate how to apply the theory and typology, what is known empirically, and whether to refer and how to engage individuals with these online resources Method Narrative review combining research and theory on both in-person and online D-RSS Results Studies targeting in-person recovery support services, such as AA and other mutual-help groups, combined with theory about how social-online D-RSS might confer benefits, suggest these digital supports may engage individuals with SUD and mobilize salutary change in similar ways While people may use in-person and digital supports simultaneously, when comparing the two modalities, communication theory and telemedicine group therapy data suggest that D-RSS may not provide the same magnitude of benefit as in-person services Research has not yet rigorously tested the effectiveness of social-online D-RSS specifically, though existing data suggest that those who use these services generally find their participation to be helpful Content analyses suggest that these services are likely to facilitate social support and unlikely to expose individuals to harmful situations Conclusions When in-person treatment and recovery support services are limited, as is the case during the COVID-19 pandemic, expected therapeutic benefits and emerging data, taken together, suggest providers, mentors, and other community leaders may wish to refer individuals to social-online D-RSS Given the array of available services with little existing data to guide specific recommendations, providers may rely upon the provided D-RSS typology as well as trusted federal, academic, and national practice organization referral lists offered here when working with patients for whom D-RSS may be appropriate
AU  - Bergman, Brandon G.
AU  - Kelly, John F.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Online digital recovery support services: An overview of the science and their potential to help individuals with substance use disorder during COVID-19 and beyond
T2  - Journal of Substance Abuse Treatment
TI  - Online digital recovery support services: An overview of the science and their potential to help individuals with substance use disorder during COVID-19 and beyond
UR  - https://doi.org/10.1016/j.jsat.2020.108152
ID  - 7793116
ER  - 

TY  - JOUR
AB  - Clostridium difficile is the most common pathogen between health care-associated infections and its incidence has increased during the last years lack of enough evidence about effective hygiene interventions to prevent this disease Due to the coronavirus disease 2019 (COVID�?9) pandemic, several strategies to reduce microorganism spread were adopted in hospital setting The objective of this study was to establish whether such strategies can reduce healthcare associated Clostridium difficile infection (HA-CDI) incidence We found that, during the pandemic (2020) HA-CDI incidence was significantly lower with respect to the previous years This work demonstrates that maintaining this level of attention regarding control activities related to prevention of microorganism transmission significantly reduce HA-CDI and related expenses in terms of health costs and human lives
AU  - Bentivegna, Enrico
AU  - Alessio, Giuliano
AU  - Spuntarelli, Valerio
AU  - Luciani, Michelangelo
AU  - Santino, Iolanda
AU  - Simmaco, Maurizio
AU  - Martelletti, Paolo
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Impact of COVID-19 prevention measures on risk of health care-associated Clostridium difficile infection
T2  - American Journal of Infection Control
TI  - Impact of COVID-19 prevention measures on risk of health care-associated Clostridium difficile infection
UR  - https://doi.org/10.1016/j.ajic.2020.09.010
ID  - 7793252
ER  - 

TY  - JOUR
AU  - Bedard, T.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Role of Nonphysician Practitioners in Oncology
T2  - Oncology Issues
TI  - The Role of Nonphysician Practitioners in Oncology
UR  - https://doi.org/10.1080/10463356.2020.1809868
ID  - 7792968
ER  - 

TY  - JOUR
AB  - COVID-19, caused by the novel coronavirus strain SARS-CoV-2 that emerged in late 2019, has resulted in a global pandemic. COVID-19 was initially believed to occur less frequently in children with relatively mild disease. However, severe disease and varied presentations have been reported in infected children, one of such being intussusception. There have only been three reported cases of intussusception in the pediatric population infected with COVID-19. In this paper, we will discuss the management and treatment of a novel fourth case of COVID-19-associated intussusception. This case is the first reported in the USA and suggests that COVID-19 may be implicated in the development of intussusception. Pediatricians should consider the possibility of intussusception when a child with COVID-19 presents with abdominal pain.
AD  - Department of Radiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Department of Radiology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA. accamach@UTMB.EDU.
School of Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Department of Pediatrics, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
AN  - 33025218
AU  - Bazuaye-Ekwuyasi, E. A.
AU  - Camacho, A. C.
AU  - Saenz Rios, F.
AU  - Torck, A.
AU  - Choi, W. J.
AU  - Aigbivbalu, E. E.
AU  - Mehdi, M. Q.
AU  - Shelton, K. J.
AU  - Radhakrishnan, G. L.
AU  - Radhakrishnan, R. S.
AU  - Swischuk, L. E.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s10140-020-01860-8
DP  - NLM
ET  - 2020/10/08
J2  - Emergency radiology
KW  - Covid-19
Coronavirus
Intussusception
Pediatrics
SARS-CoV-2
LA  - eng
N1  - 1438-1435
Bazuaye-Ekwuyasi, Eseosa Amy
Camacho, Alvin C
Orcid: 0000-0002-2762-3975
Saenz Rios, Florentino
Torck, Andrew
Choi, Woongsoon John
Aigbivbalu, Ebelosele E
Mehdi, Mohammed Q
Shelton, Kyle J
Radhakrishnan, Geetha L
Radhakrishnan, Ravi S
Swischuk, Leonard E
Journal Article
United States
Emerg Radiol. 2020 Oct 6. doi: 10.1007/s10140-020-01860-8.
PY  - 2020
SN  - 1070-3004
ST  - Intussusception in a child with COVID-19 in the USA
T2  - Emergency radiology
TI  - Intussusception in a child with COVID-19 in the USA
ID  - 7790719
ER  - 

TY  - JOUR
AB  - Rationale and Objectives This study aims to reveal the imaging features of COVID-19 in children Materials and Methods 69 chest radiographs and 37 chest CT examinations of 74 children (36 male;median (interquartile range) age:11 (6 25-15) years, 38 female;median (interquartile range) age: 12 (5 75-16) years) with positive real-time reverse transcription-polymerase chain reaction results between March 10 and May 31, 2020, were evaluated in this retrospective study Differences in 0-0 05) The rate of ground-glass opacities with or without consolidation (17/37, 45 94%) was higher than consolidation alone (6/37,16 2%) Feeding vessel sign (16/37, 43 2%), halo sign (9/37, 24 3%), pleural thickening (6/37, 16 2%), interlobular interstitial thickening (5/37,13 5%), and lymphadenopathy (3/37, 8 1%) were other imaging findings Conclusion Unilateral or bilateral distributed ground-glass opacities often associated with feeding vessel sign, halo sign, and pleural thickening on chest CT without significant differences between age groups were findings of COVID-19 in children
AU  - Bayramoglu, Zuhal
AU  - Can�\pek, Eda
AU  - Comert, Rana G.
AU  - Gasimli, Nilufar
AU  - Kaba, Ozge
AU  - Yanartaş, Mehpare Sar�\ Torun Selda Hançerli Somer
AU  - Ayper, Erturk
AU  - Sukru, Mehmet
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Imaging Features of Pediatric COVID-19 on Chest Radiography and Chest CT: A retrospective, single-center study
T2  - Academic Radiology
TI  - Imaging Features of Pediatric COVID-19 on Chest Radiography and Chest CT: A retrospective, single-center study
UR  - https://doi.org/10.1016/j.acra.2020.10.002
ID  - 7793258
ER  - 

TY  - JOUR
AU  - Battiato, Concetto
AU  - Berdini, Massimo
AU  - Luciani, Pierfrancesco
AU  - Gigante, Antonio
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Impact of Coronavirus Disease 2019 (COVID-19) on the epidemiology of orthopedics trauma in a region of central Italy
T2  - Injury
TI  - Impact of Coronavirus Disease 2019 (COVID-19) on the epidemiology of orthopedics trauma in a region of central Italy
UR  - https://doi.org/10.1016/j.injury.2020.09.044
ID  - 7793153
ER  - 

TY  - JOUR
AU  - Batra, Dinesh
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Impact of the COVID-19 on Organizational and Information Systems Agility
T2  - Information Systems Management
TI  - The Impact of the COVID-19 on Organizational and Information Systems Agility
UR  - https://doi.org/10.1080/10580530.2020.1821843
ID  - 7792966
ER  - 

TY  - JOUR
AB  - In this article, we are going to study the current COVID-19 spread patterns in India and the United States. We are interested to show how the daily increase in the total number of cases in these two countries is affecting the COVID-19 spread pattern in the World. For the study, we have considered the cumulative total numbers of cases in India, the United States and the World. We have found that the situation in the United States is already on the threshold of a change towards retardation. In the World as a whole also we have observed that a similar conclusion can be made. In India, the situation can be expected to move towards betterment soon, and once that happens the situation in the World as a whole would start improving. We shall demonstrate that as long as the rate of change of the logarithm of the cumulative total number of cases with respect to time in a pandemic continues to reduce, the pattern of growth would continue to remain nearly exponential, and as soon as it is seen that the rate of change starts to become nearly constant the growth can be expected to start to change towards a nearly logarithmic pattern.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work is not supported by any funding agency.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This work does not need approval the RBI/oversight body.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesWorldometers.info
AU  - Baruah, Hemanta Kumar
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.05.20206839
DP  - medRxiv
PY  - 2020
SP  - 2020.10.05.20206839
ST  - A Numerical Study of the Current COVID-19 Spread Patterns in India, the USA and the World (preprint)
T2  - medRxiv
TI  - A Numerical Study of the Current COVID-19 Spread Patterns in India, the USA and the World (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.05.20206839.abstract
ID  - 7794769
ER  - 

TY  - JOUR
AB  - ABSTRACT BACKGROUND: Tobacco smoking is known to increase the risk for bacterial and viral respiratory infections and this also applies to second-hand smoking. Smoking has been shown to increase the severity of COVID-19 infection and the consequent risk for intra-tracheal ventilation in smokers. Tobacco smoking exposes the user and nearby individuals to very high concentrations of particulate matter in a short period of time. Genes appertaining to COVID-19 have been found adherent to particulate matter. Particulate matter has been shown to travel beyond the social distance of 2 metres up to 10 metres. COVID-19 related mortality has been linked to elevated atmospheric levels of the particulate matter, PM2.5. The aim of the study was to observe the incidence of infection rate and case fatality ratios in the USA, comparing States with partial bans on tobacco smoking, to States with more restrictive smoking regulation, exploring a possible link between smoke-related particulate matter and COVID-19 transmission. METHODOLOGY: Two groups of USA States, differentiated by the degree of smoking legislative restrictions, had a number of variables compared. The incidence of COVID-19 infection, case-fatality ratio and testing frequency were obtained from the John Hopkins Coronavirus Resource Centre. The degree of smoking bans in the USA States was obtained from the websites of the Nonsmokers Rights Foundation. The percentage of the State population which smokes was collected from the Centres of Disease Control database. Population density, Body Mass Index and population percentages of individuals 65+/75+years were obtained from databases concerning USA demographics. RESULTS: With the available data there was no significant difference in COVID-19 testing prevalence between the partial smoking ban group and the more restrictive regulated group. The incidence of COVID-19 infection in the States with limited bans on tobacco smoking was 2046/100,000 (sd+/-827) while the infection incidence in States with more restrictive rulings on tobacco smoking was 1660/100,000 (sd+/-686) (p&amp;lt;0.038). The population percentage of smokers in States with minor limitations to smoking was 18.3% (sd+/-3.28), while States with greater smoking restrictions had a smoking population percentage of 15.2% (sd+/-2.68) (p&amp;lt;0.0006). The two populations of both groups did not differ numerically (p&amp;lt;0.24) and numbered 157,820,000 in the partial smoking ban group and 161,439,356 in the more restrictive group. Population density correlated significantly with the case-fatality ratio (R=0.66 p&amp;lt;0.0001), as did the 75+year age group (R=0.29 p&amp;lt;0.04). Reflecting the possibility of trans-border transmission, the smoking status of adjacent partial smoking ban States may influence the COVID-19 incidence of bordering States (e.g. Utah) even if the smoking regulations of the latter were stricter than the former. Other factors that could impact the COVID-19 pandemic in the USA such as the State case-fatality ratio, population density, population percentage with elevated body mass index and the percentage of the state population aged 65years or above did not show any significant difference between both groups of States. CONCLUSION: States in the USA with high levels of tobacco smoking and limited regulation had significantly higher rates of COVID-19 infection incidences than States with greater smoking restrictions. Population density and the age group of 75+years, showed a positive significant correlation with the case-fatality ratio. Besides the adverse effects of tobacco smoking on pulmonary defences, it would be interesting to explore the possibility of infection transmission via coronavirus-laden particulate matter from exhaled fumes derived from tobacco smoking. Keywords: tobacco smoking; second-hand smoking; COVID-19; incidence: case-fatality ratio; population density; 75+ age group;Competing Interest StatementThe authors have declared no competing interest.Funding StatementNILAuthor DeclarationsI confirm all relevant ethical guidelines hav been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:NILAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData was obtained from Internet links and websiteshttps://coronavirus.jhu.edu/maphttp://www.cy118119.com.dadastatisticshttps://datausa.iohttps://obs.withings.com
AU  - Baron, Yves Muscat
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206383
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206383
ST  - Incidence and Case-Fatality Ratio of COVID-19 infection in relation to Tobacco Smoking, Population Density and Age Demographics in the USA : could Particulate Matter derived from Tobacco Smoking act as a Vector for COVID-19 transmission? (preprint)
T2  - medRxiv
TI  - Incidence and Case-Fatality Ratio of COVID-19 infection in relation to Tobacco Smoking, Population Density and Age Demographics in the USA : could Particulate Matter derived from Tobacco Smoking act as a Vector for COVID-19 transmission? (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206383.abstract
ID  - 7794732
ER  - 

TY  - JOUR
AU  - Barlow, Kate
AU  - Sepulveda, Aviril
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The promotion of positive mental health for new mothers during Covid-19
T2  - World Federation of Occupational Therapists Bulletin
TI  - The promotion of positive mental health for new mothers during Covid-19
UR  - https://doi.org/10.1080/14473828.2020.1822577
ID  - 7792958
ER  - 

TY  - JOUR
AB  - Resumen INTRODUCCIÓN: Uno de los principales retos en el manejo de la COVID 19 es el aumento súbito de la demanda de camas de cuidados intensivos En este art�Tculo se describen las estrategias de gesti�Qn hospitalaria durante la escalada y desescalada de la respuesta a la epidemia de COVID-19 en un hospital terciario de Madrid MATERIALES Y MÉTODOS: Los datos derivan del sistema inform֙tico del hospital y del plan de contingencia del mismo RESULTADOS: La epidemia de COVID-19 produjo un r֙pido aumento de los pacientes con necesidad de cuidados intensivos, lo que satur�Q las camas de UVI disponibles en pocos d�Tas El hospital tuvo que aumentar su capacidad abriendo cuatro UVIs adicionales para proporcionar los cuidados necesarios a todos los pacientes Los retos principales fueron relativos a la infraestructura hospitalaria, los materiales y el personal Gracias a las estrategias de gesti�Qn utilizadas, el hospital fue capaz de aumentar su capacidad de camas de UVI en un 340%, proporcionar cuidados a todos los pacientes con necesidad, y mantener una m�Tnima actividad quirúrgica programada CONCLUSIONES: La capacidad de un hospital de aumentar su capacidad para enfrentarse a eventos excepcionales es dif�Tcil de cuantificar y se enfrenta a limitaciones f�Tsicas (materiales, personal, espacios) Con una gesti�Qn flexible y adaptable durante eventos excepcionales se pueden alargar significativamente estos l�Tmites
AU  - Bardi, Tommaso
AU  - Gomez-Rojo, Maria
AU  - Candela, Angel M.
AU  - de Pablo, Raul
AU  - Martinez, Rafael
AU  - Pestaña, David
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Rapid response to COVID-19, escalation and de-escalation strategies to match surge capacity of Intensive Care beds to a large scale epidemic
T2  - Revista Española de Anestesiolog�Ta y Reanimaci�Qn
TI  - Rapid response to COVID-19, escalation and de-escalation strategies to match surge capacity of Intensive Care beds to a large scale epidemic
UR  - https://doi.org/10.1016/j.redar.2020.09.003
ID  - 7793063
ER  - 

TY  - JOUR
AB  - BACKGROUND: Coronavirus disease 2019 (COVID-19) is spreading rapidly in the world, and on 11 March 2020, WHO announced the outbreak a global pandemic. Given the severity of this major outbreak and the importance of prevention and protection against the spread of SARS-CoV-2, the predictors of engaging in the preventive behaviours could potentially be of great practical importance as it could help us identify high-risk groups and take the necessary steps towards improving their health behaviour. As the health behavioural response of the Egyptian population during COVID-19 is unknown and the health belief model constructs can be used to explain health behaviour, this study was conducted to assess the preventive behaviours to COVID-19 and the associated role of health belief model constructs over three periods of time; at the beginning of COVID-19 pandemic then 4 weeks and10 weeks later. RESULTS: Perceived severity and benefits of health belief model constructs showed significant decrease in the 2(nd) interview, followed by an increase in the 3(rd) interview (P �?.001). Perceived barriers showed a significant increase in the 2(nd) interview followed by a significant decrease in the 3(rd) interview (P �?.001). Knowledge score was significantly lower at the start, then a surge happened in the next interview followed by a slight drop in the 3(rd) interview (P �?.001). Preventive behaviours were significantly lower in the 2(nd) interview then significantly higher in the 3(rd) interview (P �?.001). On the analysis of the factors associated with preventive behaviours using multivariate regression, the results determined age, high education, being a health care worker, perceived susceptibility, benefits, barriers and self-efficacy. CONCLUSIONS: Perceptions of benefits could be increased by tailoring communication strategies to various groups, emphasizing how different people can engage in effective preventive behaviours. Policy makers should pay attention to lower-educated persons living in rural areas being a group with the least engagement in health-protective actions.
AN  - PMC7535951
AU  - Barakat, Ayah M.
AU  - Kasemy, Zeinab A.
C1  - 10/7/2020
DB  - PMC
DO  - 10.1186/s43045-020-00051-y
DP  - NLM
ET  - 2020/10/06
IS  - 1
KW  - Preventive health behaviours
COVID-19
Health belief model
LA  - eng
N1  - PMC7535951[pmcid]
PY  - 2020
SN  - 2090-5416
SP  - 43
ST  - Preventive health behaviours during coronavirus disease 2019 pandemic based on health belief model among Egyptians
T2  - Middle East Current Psychiatry, Ain Shams University
TI  - Preventive health behaviours during coronavirus disease 2019 pandemic based on health belief model among Egyptians
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7535951/
VL  - 27
ID  - 7790663
ER  - 

TY  - JOUR
AB  - The aim of this study was to test in vitro the ability of a mixture of citrus extract, maltodextrin, sodium chloride, lactic acid and citric acid (AuraShield L) to inhibit the virulence of infectious bronchitis, Newcastle disease, avian influenza, porcine reproductive and respiratory syndrome (PRRS) and bovine coronavirus viruses. Secondly, in vivo, we have investigated its efficacy against infectious bronchitis using a broiler infection model. In vitro, these antimicrobials had expressed antiviral activity against all five viruses through all phases of the infection process of the host cells. In vivo, the antimicrobial mixture reduced the virus load in the tracheal and lung tissue and significantly reduced the clinical signs of infection and the mortality rate in the experimental group E2 receiving AuraShield L. All these effects were accompanied by a significant reduction in the levels of pro-inflammatory cytokines and an increase in IgA levels and short chain fatty acids (SCFAs) in both trachea and lungs. Our study demonstrated that mixtures of natural antimicrobials, such AuraShield L, can prevent in vitro viral infection of cell cultures. Secondly, in vivo, the efficiency of vaccination was improved by preventing secondary viral infections through a mechanism involving significant increases in SCFA production and increased IgA levels. As a consequence the clinical signs of secondary infections were significantly reduced resulting in recovered production performance and lower mortality rates in the experimental group E2.
AD  - Bacteriology Branch, Veterinary Sciences Division, Agri-Food and Biosciences Institute, 18a Newforge Lane, Belfast, BT9 5PX, Northern Ireland, UK.
Faculty of Animal Science and Biotechnologies, University of Agricultural Sciences and Veterinary Medicine, 400372, Cluj-Napoca, Romania.
Faculty of Bioengineering of Animal Resources, Banat University of Animal Sciences and Veterinary Medicine - King Michael I of Romania, Timisoara, Romania.
Auranta, Nova UCD, Belfield, Dublin 4, Ireland.
Department of Animal and Dairy Science, University of Georgia, Athens, GA, USA.
Center for Food Safety, Department of Food Science, University of Arkansas, Fayetteville, AR, USA.
Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, 13 Keppel Street, London, WC1E 7HT, UK. ozan.gundogdu@lshtm.ac.uk.
Bacteriology Branch, Veterinary Sciences Division, Agri-Food and Biosciences Institute, 18a Newforge Lane, Belfast, BT9 5PX, Northern Ireland, UK. nicolae.corcionivoschi@afbini.gov.uk.
Faculty of Animal Science and Biotechnologies, University of Agricultural Sciences and Veterinary Medicine, 400372, Cluj-Napoca, Romania. nicolae.corcionivoschi@afbini.gov.uk.
Faculty of Bioengineering of Animal Resources, Banat University of Animal Sciences and Veterinary Medicine - King Michael I of Romania, Timisoara, Romania. nicolae.corcionivoschi@afbini.gov.uk.
AN  - 33024252
AU  - Balta, I.
AU  - Stef, L.
AU  - Pet, I.
AU  - Ward, P.
AU  - Callaway, T.
AU  - Ricke, S. C.
AU  - Gundogdu, O.
AU  - Corcionivoschi, N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73916-1
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Balta, Igori
Stef, Lavinia
Pet, Ioan
Ward, Patrick
Callaway, Todd
Ricke, Steven C
Gundogdu, Ozan
Corcionivoschi, Nicolae
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16631. doi: 10.1038/s41598-020-73916-1.
PY  - 2020
SN  - 2045-2322
SP  - 16631
ST  - Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo
T2  - Scientific reports
TI  - Antiviral activity of a novel mixture of natural antimicrobials, in vitro, and in a chicken infection model in vivo
VL  - 10
ID  - 7790830
ER  - 

TY  - JOUR
AB  - Introduction Management of COVID-19 pneumonia cases is a medical challenge However, the situation becomes worse if the patient has coexisting morbidities or newly developed complications The study is about managing rectus sheath haematoma (RSH) in a patient with COVID-19 pneumonia Presentation of case The patient was a 75-year-old male, presenting with bilateral COVID-19 pneumonia, with pulmonary embolism complications Therapeutic anticoagulation by subcutaneous Clexane injection was administered A left rectus haematoma was observed, and the patient fell and underwent haemorrhagic shock Laparotomy was done for the evacuation of the haematoma Discussion Contrast-enhanced computed tomography (CECT) is an essential tool for diagnosing RSH, identifying the source of bleeding, type of haematoma, and compression of the urinary system Conclusion Surgical management of RSH in COVID-19 patients is superior to interventional radiology during the rush pandemic period
AU  - Bakirov, Ifrat
AU  - Bakirova, Gultakin
AU  - Albalawi, Yousef
AU  - Asiri, Ayed Y.
AU  - Faqihi, Fahad
AU  - Bakirli, Ilkin
AU  - Hammami, Dema
AU  - Bakirli, Hasan
AU  - Mandow, Najmeddin M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Left inferior epigastric artery injury in COVID-19 patient. Case report and literature review
T2  - International Journal of Surgery Case Reports
TI  - Left inferior epigastric artery injury in COVID-19 patient. Case report and literature review
UR  - https://doi.org/10.1016/j.ijscr.2020.09.198
ID  - 7793157
ER  - 

TY  - JOUR
AD  - University of Otago, Wellington, 23 Mein Street, Newtown, Wellington 6021, New Zealand.
AN  - 33023885
AU  - Baker, M. G.
AU  - Wilson, N.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/bmj.m3883
DP  - NLM
ET  - 2020/10/08
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Baker, Michael G
Wilson, Nick
Letter
England
BMJ. 2020 Oct 6;371:m3883. doi: 10.1136/bmj.m3883.
PY  - 2020
SN  - 0959-8138
SP  - m3883
ST  - The covid-19 elimination debate needs correct data
T2  - BMJ
TI  - The covid-19 elimination debate needs correct data
VL  - 371
ID  - 7790868
ER  - 

TY  - JOUR
AB  - Since the first recognition that infectious microbes serve as the causes of many human diseases, physicians and scientists have sought to understand and control their spread. For the past 150+ years, these 'microbe hunters' have learned to combine epidemiological information with knowledge of the infectious agent(s). In this essay, I reflect on the evolution of microbe hunting, beginning with the history of pre-germ theory epidemiological studies, through the microbiological and molecular eras. Now in the genomic age, modern-day microbe hunters are combining pathogen whole-genome sequencing with epidemiological data to enhance epidemiological investigations, advance our understanding of the natural history of pathogens and drivers of disease, and ultimately reshape our plans and priorities for global disease control and eradication. Indeed, as we have seen during the ongoing Covid-19 pandemic, the role of microbe hunters is now more important than ever. Despite the advances already made by microbial genomic epidemiology, the field is still maturing, with many more exciting developments on the horizon.
AD  - University of Liverpool, Institute for Infection, Ecology and Veterinary Sciences, Department of Clinical Infection, Microbiology, and Immunology, Liverpool L69 7ZB, UK. Electronic address: kbaker@liverpool.ac.uk.
AN  - 33022254
AU  - Baker, K. S.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1016/j.cub.2020.06.097
DP  - NLM
ET  - 2020/10/07
IS  - 19
J2  - Current biology : CB
LA  - eng
N1  - 1879-0445
Baker, Kate S
Journal Article
England
Curr Biol. 2020 Oct 5;30(19):R1124-R1130. doi: 10.1016/j.cub.2020.06.097.
PY  - 2020
SN  - 0960-9822
SP  - R1124-r1130
ST  - Microbe hunting in the modern era: reflecting on a decade of microbial genomic epidemiology
T2  - Current biology : CB
TI  - Microbe hunting in the modern era: reflecting on a decade of microbial genomic epidemiology
VL  - 30
ID  - 7790974
ER  - 

TY  - JOUR
AB  - Clinical laboratories across the world are working to validate and perform testing for SARS-CoV-2 antibodies. Herein, we present interim consensus guidance for Canadian clinical laboratories testing and reporting SARS-CoV-2 serology, with emphasis on the capabilities and limitations of these tests and recommendations for interpretative comments in an effort to achieve harmonized laboratory practices. The consensus document provides a broad overview of topics including sample type and contamination risk; kinetics of antibody response to COVID-19 and the impact on serology testing; clinical utility of SARS-CoV-2 serology testing; clinical performance of commercial laboratory-based assays commonly deployed in North America; recommendations for interim reporting; utility of SARS-CoV-2 antibody testing for pediatric patients; and utility of point-of-care testing. The information is based on the current literature and is subject to change as additional information becomes available.
AN  - PMC7536550
AU  - Bailey, Dana
AU  - Konforte, Danijela
AU  - Barakauskas, Vilte E.
AU  - Yip, Paul M.
AU  - Kulasingam, Vathany
AU  - Abou El Hassan, Mohamed
AU  - Beach, Lori A.
AU  - Blasutig, Ivan M.
AU  - Catomeris, Peter
AU  - Dooley, Kent C.
AU  - Gong, Yanping
AU  - Kavsak, Peter
AU  - Randell, Edward W.
AU  - Robinson, Jason L.
AU  - Shaw, Julie
AU  - Taher, Jennifer
AU  - White-Al Habeeb, Nicole
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.clinbiochem.2020.09.005
DP  - NLM
J2  - Clin Biochem
KW  - COVID-19, Coronavirus Disease 2019, disease caused by SARS-CoV-2
IFU, Instructions for Use
IgA, Immunoglobulin isotype A
IgG, Immunoglobulin isotype G
IgM, Immunoglobulin isotype M
LOINC, Logical Observation Identifiers Names and Codes
NAAT, Nucleic acid amplification tests
NPV, Negative predictive value
MIS-C, Multisystem inflammatory syndrome in children
PPV, Positive predictive value
RT-PCR, Real-time Polymerase Chain Reaction
SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 of the genus Betacoronavirus
SARS-CoV-2, serology specimens and specimen contamination risk
LA  - eng
N1  - PMC7536550[pmcid]
S0009-9120(20)30844-4[PII]
PY  - 2020
SN  - 0009-9120
1873-2933
ST  - Canadian Society of Clinical Chemists (CSCC) Interim Consensus Guidance for Testing and Reporting of SARS-CoV-2 Serology
T2  - Clinical Biochemistry
TI  - Canadian Society of Clinical Chemists (CSCC) Interim Consensus Guidance for Testing and Reporting of SARS-CoV-2 Serology
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536550/
ID  - 7790676
ER  - 

TY  - JOUR
AB  - Azadirachta Indica (Neem) extracts have been known for their anti-bacterial and other effects since ancient times The present work examines the inhibitory activity of Neem extracts on Papain like protease (PLpro) of the novel coronavirus SARS-CoV-2 The activity is analysed by molecular docking study along with molecular dynamics simulation All the studied Neem compounds showed decent level of inhibitory activities against PLpro of SARS-CoV-2 Among them, desacetylgedunin (DCG) found in Neem seed showed the highest binding affinity towards PLpro Furthermore, MD-simulation studies supported by standard analysis (e g root mean square deviation and fluctuation (RMSD, RMSF), radius of gyration, solvent accessible surface area (SASA)) showed large impact on the structure of PLpro by DCG We believe that the significant effect of DCG on PLpro may help in therapeutic efforts against SARS-CoV-2
AU  - Baildya, Nabajyoti
AU  - Khan, Abdul Ashik
AU  - Ghosh, Narendra Nath
AU  - Dutta, Tanmoy
AU  - Chattopadhyay, Asoke P.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Screening of potential drug from Azadiractha Indica (Neem) extracts for SARS-CoV-2: An insight from molecular docking and MD-simulation studies
T2  - Journal of Molecular Structure
TI  - Screening of potential drug from Azadiractha Indica (Neem) extracts for SARS-CoV-2: An insight from molecular docking and MD-simulation studies
UR  - https://doi.org/10.1016/j.molstruc.2020.129390
ID  - 7793090
ER  - 

TY  - JOUR
AU  - Bagenstos, Samuel R.
C1  - 10/7/2020
DB  - SSRN
DP  - SSRN
KW  - disability, urban planning, infrastructure, transportation, smart cities
PY  - 2020
ST  - Towards an Urban Disability Agenda (preprint)
T2  - SSRN
TI  - Towards an Urban Disability Agenda (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3661665
ID  - 7794796
ER  - 

TY  - JOUR
AD  - Department of Otolaryngology, Icahn School of Medicine at Mount Sinai, New York, New York.
AN  - 33022068
AU  - Badhey, A. K.
AU  - Laitman, B. M.
C1  - 10/7/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1001/jamaoto.2020.3232
DP  - NLM
ET  - 2020/10/07
J2  - JAMA otolaryngology-- head & neck surgery
LA  - eng
N1  - 2168-619x
Badhey, Arvind K
Laitman, Benjamin M
Journal Article
United States
JAMA Otolaryngol Head Neck Surg. 2020 Oct 1. doi: 10.1001/jamaoto.2020.3232.
PY  - 2020
SN  - 2168-6181
ST  - If Not Us, Who? And If Not Now, When?: Perspective From a COVID-19 Intensive Care Unit Run by Otolaryngology Residents
T2  - JAMA otolaryngology-- head & neck surgery
TI  - If Not Us, Who? And If Not Now, When?: Perspective From a COVID-19 Intensive Care Unit Run by Otolaryngology Residents
ID  - 7790984
ER  - 

TY  - JOUR
AB  - Background The actual pandemic outbreak is the third time in the last two decades in which a coronavirus results in a major global spread with serious consequences in terms of vastity of affected patients, life losses, health system organization efforts and socio-economic implications Lacking effective therapies and vaccinations, during viral outbreak the major and most incisive mean for viral spread control is spread prevention, especially for the fragile burn-injured patients we are called to care for in Burn Units Methods We developed an admission and inpatient management protocol to preserve burn patients from SARS-CoV-2 contagion, in order to avoid additional morbidity and mortality in patients with already compromised health conditions Data from burn-injured patients admitted to our Unit following this new protocol were retrospectively analyzed in order to verify its effectiveness in prevention of viral spread Results From the 8th of March to the 8th of June, we admitted 18 patients in the Burn Unit ICU and semi-ICU and 17 patients in the Burn Ward Two of them resulted positive to COVID-19 nasopharyngeal swab and bronchoalveolar lavage collected immediately on admission, for both the extension of burns and their general clinical conditions implied ICU admission Moreover, a caregiver of an admitted child resulted positive to the nasopharyngeal swab No other cases of SARS-CoV-2 positivity have been reported neither between hospitalized patients nor between healthcare workers Conclusion The evidence of high ICU admission rate and high mortality in patients affected by SARS-CoV-2 combined with the fragile clinical conditions of burn patients required the development of an admission and hospitalization management protocol which proved itself effective in minimizing viral spread among patients and healthcare workers
AU  - Azzena, Bruno
AU  - Perozzo, Filippo Andrea Giovanni
AU  - De Lazzari, Alberto
AU  - Valotto, Giovanni
AU  - Pontini, Alex
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Burn Unit admission and management protocol during COVID-19 pandemic
T2  - Burns
TI  - Burn Unit admission and management protocol during COVID-19 pandemic
UR  - https://doi.org/10.1016/j.burns.2020.09.004
ID  - 7793219
ER  - 

TY  - JOUR
AB  - Resumen La infecci�Qn por el coronavirus asociada al s�Tndrome de distrés respiratorio agudo severo (SARS-CoV-2) produce un s�Tndrome cl�Tnico denominado mundialmente covid-19 que ha generado 5 940 441 infectados y 362 813 muertes hasta mayo de 20201 En estadios moderados y severos de la infecci�Qn se produce una reacci�Qn sistémica del organismo caracterizada por la hiperinflamaci�Qn, tormenta de citocinas y elevaci�Qn de biomarcadores de daño mioc֙rdico Adem֙s, se ha sugerido la relaci�Qn entre covid-19 y manifestaciones neurol�Qgicas Recientes autopsias sugieren microangiopat�Ta tromb�Qtica en múltiples �Qrganos Presentamos la descripci�Qn de 2 casos de pacientes con covid-19 severo, ingresados en Reanimaci�Qn, que presentaron afectaci�Qn cerebrovascular y fallecieron posteriormente Se recomienda estrictamente la aplicaci�Qn de profilaxis farmacol�Qgica antitromb�Qtica en los pacientes afectados por covid-19 ingresados en cuidados cr�Tticos y se sugiere administrar dosis profil֙cticas por encima de la media Coronavirus associated severe acute respiratory syndrome (SARS-CoV-2) causes a worldwide syndrome called Covid-19 that has caused 5,940,441 infections and 362,813 deaths until May 2020 In moderate and severe stages of the infection a generalized swelling, cytokine storm and an increment of the heart damage biomarkers occur In addition, a relation between Covid-19 and neurological symptoms have been suggested The results of autopsies suggest thrombotic microangiopathy in multiple organs We present 2 cases of patients infected with severe Covid-19 that were hospitalized in the Reanimation Unit that presented cerebrovascular symptoms and died afterwards A high dose prophylaxis with antithrombotic medication is recommended in patients affected by moderate to severe Covid-19
AU  - Azpaiazu Landa, N.
AU  - Velasco Oficialdegui, C.
AU  - Intxaurraga Fern֙ndez, K.
AU  - Gonzalez Larrabe, I.
AU  - Riaño Onaindia, S.
AU  - Telletxea Benguria, S.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Afectaci�Qn cerebrovascular isquémico-hemorr֙gica en pacientes con covid-19
T2  - Revista Española de Anestesiolog�Ta y Reanimaci�Qn
TI  - Afectaci�Qn cerebrovascular isquémico-hemorr֙gica en pacientes con covid-19
UR  - https://doi.org/10.1016/j.redar.2020.08.002
ID  - 7793064
ER  - 

TY  - JOUR
AB  - Si la vaccination a permis de freiner la propagation de certaines maladies infectieuses et de limiter les épidémies, l’éducation à l’hygi؈ne et à la santé, la rédaction de protocoles et la formation ont rendu les soins encore plus sécuritaires pour les malades et le personnel hospitalier Une rétrospective des grandes pandémies et une analyse de la crise de la Covid-19 montrent qu’il faut demeurer tr؈s vigilant En milieu de soins, la notion de protection et d’hygi؈ne reste, encore de nos jours, primordiale Preventing the risk of infection in the health care setting through barrier measures While vaccination has helped to slow the spread of some infectious diseases and limit epidemics, hygiene and health education, protocol writing and training have made health care even safer for patients and hospital staff A retrospective review of major pandemics and an analysis of the Covid-19 crisis show that we must remain very vigilant In the health care setting, the notion of protection and hygiene remains, even today, paramount
AU  - Aumeran, Claire
AU  - Jacomet, Christine
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Prévenir le risque infectieux en milieu de soins grâce aux mesures barri؈re
T2  - Sages-Femmes
TI  - Prévenir le risque infectieux en milieu de soins grâce aux mesures barri؈re
UR  - https://doi.org/10.1016/j.sagf.2020.07.004
ID  - 7793057
ER  - 

TY  - JOUR
AB  - Having lived through the havoc of COVID-19 in a hospital situated in one of the hardest hit zip codes in the United States, the thought that another wave could loom in the fall is bracing. Further, we are acutely aware of the herculean effort it took to reorganize the service to accommodate the needs of women infected with this new pathogen.
AD  - Department of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York.
Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, Brooklyn, New York.
AN  - 33025694
AU  - Atallah, F.
AU  - Minkoff, H.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/1471-0528.16551
DP  - NLM
ET  - 2020/10/08
J2  - BJOG : an international journal of obstetrics and gynaecology
LA  - eng
N1  - 1471-0528
Atallah, Fouad
Orcid: 0000-0003-1442-0252
Minkoff, Howard
Journal Article
England
BJOG. 2020 Oct 6. doi: 10.1111/1471-0528.16551.
PY  - 2020
SN  - 1470-0328
ST  - During the second wave of COVID-19, don't forget about influenza: a call to action
T2  - BJOG : an international journal of obstetrics and gynaecology
TI  - During the second wave of COVID-19, don't forget about influenza: a call to action
ID  - 7790685
ER  - 

TY  - JOUR
AU  - Assaf, Maher
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A new experience of online education under the COVID-19 pandemic for occupational therapy students in Palestine
T2  - World Federation of Occupational Therapists Bulletin
TI  - A new experience of online education under the COVID-19 pandemic for occupational therapy students in Palestine
UR  - https://doi.org/10.1080/14473828.2020.1825274
ID  - 7792956
ER  - 

TY  - JOUR
AB  - Background As the number of COVID-19 cases continues to rise, public health efforts must focus on preventing avoidable fatalities Understanding the demographic and clinical characteristics of deceased COVID-19 patients;and estimation of time-interval between symptom onset, hospital admission and death could inform public health interventions focusing on preventing mortality due to COVID-19 Methods We obtained COVID-19 death summaries from the official dashboard of the Government of Tamil Nadu, between 10th May and July 10, 2020 Of the 1,783 deaths, we included 1,761 cases for analysis Results The mean age of the deceased was 62 5 years (SD: 13 7) The crude death rate was 2 44 per 100,000 population;the age-specific death rate was 22 72 among above 75 years and 0 02 among less than 14 years, and it was higher among men (3 5 vs 1 4 per 100,000 population) Around 85% reported having any one or more comorbidities;Diabetes (62%), hypertension (49 2%) and CAD (17 5%) were the commonly reported comorbidities The median time interval between symptom onset and hospital admission was 4 days (IQR: 2, 7);admission and death was 4 days (IQR: 2, 7) with a significant difference between the type of admitting hospital One-fourth of (24 2%) deaths occurred within a day of hospital admission Conclusion Elderly, male, people living in densely populated areas and people with underlying comorbidities die disproportionately due to COVID-19 While shorter time-interval between symptom onset and admission is essential, the relatively short time interval between admission and death is a concern and the possible reasons must be evaluated and addressed to reduce avoidable mortality
AU  - Asirvatham, Edwin Sam
AU  - Sarman, Charishma Jones
AU  - Saravanamurthy, Sakthivel P.
AU  - Mahalingam, Periasamy
AU  - Maduraipandian, Swarna
AU  - Lakshmanan, Jeyaseelan
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Who is dying from COVID-19 and when? An Analysis of fatalities in Tamil Nadu, India
T2  - Clinical Epidemiology and Global Health
TI  - Who is dying from COVID-19 and when? An Analysis of fatalities in Tamil Nadu, India
UR  - https://doi.org/10.1016/j.cegh.2020.09.010
ID  - 7793214
ER  - 

TY  - JOUR
AB  - The control of spreading of COVID-19 in emergency situation the entire world is a challenge, and therefore, the aim of this study was to propose a spherical intelligent fuzzy decision model for control and diagnosis of COVID-19. The emergency event is known to have aspects of short time and data, harmfulness, and ambiguity, and policy makers are often rationally bounded under uncertainty and threat. There are some classic approaches for representing and explaining the complexity and vagueness of the information. The effective tool to describe and reduce the uncertainty in data information is fuzzy set and their extension. Therefore, we used fuzzy logic to develop fuzzy mathematical model for control of transmission and spreading of COVID19. The fuzzy control of early transmission and spreading of coronavirus by fuzzy mathematical model will be very effective. The proposed research work is on fuzzy mathematical model of intelligent decision systems under the spherical fuzzy information. In the proposed work, we will develop a newly and generalized technique for COVID19 based on the technique for order of preference by similarity to ideal solution (TOPSIS) and complex proportional assessment (COPRAS) methods under spherical fuzzy environment. Finally, an illustrative the emergency situation of COVID-19 is given for demonstrating the effectiveness of the suggested method, along with a sensitivity analysis and comparative analysis, showing the feasibility and reliability of its results.
AD  - Department of Mathematics, Abdul Wali Khan University, Mardan, 23200 Pakistan. GRID: grid.440522.5. ISNI: 0000 0004 0478 6450
Department of Information Systems, Faculty of Computing and Information Technology, King Abdulaziz University, Jeddah, Saudi Arabia. GRID: grid.412125.1. ISNI: 0000 0001 0619 1117
AN  - 33024412
AU  - Ashraf, S.
AU  - Abdullah, S.
AU  - Almagrabi, A. O.
C1  - 10/7/2020
C2  - PMC7529095
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s00500-020-05287-8
DP  - NLM
ET  - 2020/10/08
J2  - Soft computing
KW  - Critical path problems
Emergency decision making of COVID-19
Intelligent decision support systems
Spherical fuzzy set
LA  - eng
N1  - Ashraf, Shahzaib
Abdullah, Saleem
Almagrabi, Alaa O
Journal Article
Germany
Soft comput. 2020 Oct 1:1-17. doi: 10.1007/s00500-020-05287-8.
PY  - 2020
SN  - 1432-7643 (Print)
1432-7643
SP  - 1-17
ST  - A new emergency response of spherical intelligent fuzzy decision process to diagnose of COVID19
T2  - Soft computing
TI  - A new emergency response of spherical intelligent fuzzy decision process to diagnose of COVID19
ID  - 7790798
ER  - 

TY  - JOUR
AB  - BACKGROUND: The COVID-19 pandemic has had a far-reaching negative impact on healthcare systems worldwide and has placed healthcare providers under immense physiological and psychological pressures. OBJECTIVE: The aim of current study was to undertake an in-depth exploration of the experiences of health-care staff working during the COVID-19 crisis. METHODS: Using a thematic analysis approach, a qualitative study was conducted using semi-structured interviews with 97 health care professionals. Participants were health care professionals including pre-hospital emergency services (EMS), physicians, nurses, pharmacists, laboratory personnel, radiology technicians, hospital managers and managers in the ministry of health who work directly or indirectly with COVID-19 cases. RESULTS: Data analysis highlighted four main themes, namely: ‘Working in the pandemic era�? ‘Changes in personal life and enhanced negative affect�? ‘Gaining experience, normalization and adaptation to the pandemic�?and ‘Mental Health Considerations�?which indicated that mental ill deteriorations unfolded through a stage-wise process as the pandemic unfolded. CONCLUSIONS: Participants experienced a wide range of emotions and development during the unfolding of the pandemic. Providing mental health aid should thus be an essential part of services for healthcare providers during the pandemic. Based on our results the aid should be focused on the various stages and should be individual-centred. Such interventions are crucial to sustain workers in their ability to cope throughout the duration of the pandemic.
AN  - PMC7536124
AU  - Ardebili, Dr Mehrdad Eftekhar
AU  - Naserbakht, Dr Morteza
AU  - Colleen, Dr Bernstein
AU  - Alazmani-Noodeh, Mr Farshid
AU  - Hakimi, Mrs Hamideh
AU  - Ranjbar, Dr Hadi
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.ajic.2020.10.001
DP  - NLM
J2  - Am J Infect Control
KW  - COVID-19
Pandemic
Healthcare Providers
Mental Health
Qualitative study
LA  - eng
N1  - PMC7536124[pmcid]
S0196-6553(20)30896-8[PII]
PY  - 2020
SN  - 0196-6553
1527-3296
ST  - Healthcare providers experience of working during the COVID-19 pandemic: A qualitative study
T2  - American Journal of Infection Control
TI  - Healthcare providers experience of working during the COVID-19 pandemic: A qualitative study
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536124/
ID  - 7790668
ER  - 

TY  - JOUR
AB  - Several outbreak prediction models for COVID-19 are being used by officials around the world to make informed decisions and enforce relevant control measures Among the standard models for COVID-19 global pandemic prediction, simple epidemiological and statistical models have received more attention by authorities, and these models are popular in the media Due to a high level of uncertainty and lack of essential data, standard models have shown low accuracy for long-term prediction Although the literature includes several attempts to address this issue, the essential generalization and robustness abilities of existing models need to be improved This paper presents a comparative analysis of machine learning and soft computing models to predict the COVID-19 outbreak as an alternative to susceptible&amp;ndash;infected&amp;ndash;recovered (SIR) and susceptible-exposed-infectious-removed (SEIR) models Among a wide range of machine learning models investigated, two models showed promising results (i e , multi-layered perceptron, MLP;and adaptive network-based fuzzy inference system, ANFIS) Based on the results reported here, and due to the highly complex nature of the COVID-19 outbreak and variation in its behavior across nations, this study suggests machine learning as an effective tool to model the outbreak This paper provides an initial benchmarking to demonstrate the potential of machine learning for future research This paper further suggests that a genuine novelty in outbreak prediction can be realized by integrating machine learning and SEIR models
AU  - Ardabili, Sina F.
AU  - Mosavi, Amir
AU  - Ghamisi, Pedram
AU  - Ferdinand, Filip
AU  - Varkonyi-Koczy, Annamaria R.
AU  - Reuter, Uwe
AU  - Rabczuk, Timon
AU  - Atkinson, Peter M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 Outbreak Prediction with Machine Learning
T2  - Algorithms
TI  - COVID-19 Outbreak Prediction with Machine Learning
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813173
ID  - 7793373
ER  - 

TY  - JOUR
AB  - In this work, a model for the simulation of infectious disease outbreaks including mobility data is presented The model is based on the SAIR compartmental model and includes mobility data terms that model the flow of people between different regions The aim of the model is to analyze the influence of mobility on the evolution of a disease after a lockdown period and to study the appearance of small epidemic outbreaks due to the so-called imported cases We apply the model to the simulation of the COVID-19 in the various areas of Spain, for which the authorities made available mobility data based on the position of cell phones We also introduce a method for the estimation of incomplete mobility data Some numerical experiments show the importance of data completion and indicate that the model is able to qualitatively simulate the spread tendencies of small outbreaks This work was motivated by an open call made to the mathematical community in Spain to help predict the spread of the epidemic
AU  - Aràndiga, Francesc
AU  - Baeza, Antonio
AU  - Cordero-Carri�Qn, Isabel
AU  - Donat, Rosa
AU  - Mart�T, M. Carmen Mulet
AU  - Pep, Y֙ñez Dionisio F.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A Spatial-Temporal Model for the Evolution of the COVID-19 Pandemic in Spain Including Mobility
T2  - Mathematics
TI  - A Spatial-Temporal Model for the Evolution of the COVID-19 Pandemic in Spain Including Mobility
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813172
ID  - 7793374
ER  - 

TY  - JOUR
AB  - The emergence of the COVID-19 pandemic has disrupted patient day-to-day life with limitations to social practices (e.g., physical distancing, mask wearing and frequent hand hygiene).1 These limitations together with widespread anxiety, stress have generated a mental health crisis among patients.2 Anxiety, fear and panic about COVID-19 may result in strong emotions and reactions.1-3 Therefore, a survey was conducted to evaluate COVID-associated patient emotions, confidence in hospital infection prevention (IP) toward IP behaviors in outpatient departments.
AD  - Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Prathum Thani, Thailand.
Manorom Hospital, Bangkok, Thailand.
Division of Diagnostic Radiology, Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Research and Consulting Service, Michael Ullmann Consulting, USA.
Bumrungrad Hospital, Bangkok, Thailand.
Department of Ophthalmology, Rutnin Hospital, Bangkok, Thailand.
Division of Infectious Diseases, University of North Carolina, Chapel Hill, USA.
AN  - 33023718
AU  - Apisarnthanarak, A.
AU  - Siripraparat, C.
AU  - Apisarnthanarak, P.
AU  - Ullmann, M.
AU  - Saengaram, P.
AU  - Leeprechanon, N.
AU  - Weber, D. J.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1017/ice.2020.1240
DP  - NLM
ET  - 2020/10/08
J2  - Infection control and hospital epidemiology
KW  - Covid-19
anxiety
confidence
fear
infection control practices
patients
LA  - eng
N1  - 1559-6834
Apisarnthanarak, Anucha
Orcid: 0000-0003-2363-6362
Siripraparat, Chanida
Apisarnthanarak, Piyaporn
Ullmann, Michael
Saengaram, Pavarat
Leeprechanon, Narakorn
Weber, David J
Journal Article
United States
Infect Control Hosp Epidemiol. 2020 Oct 7:1-8. doi: 10.1017/ice.2020.1240.
PY  - 2020
SN  - 0899-823x
SP  - 1-8
ST  - Patients' Anxiety, Fear and Panic for COVID-19 and Confidence in Hospital Infection Control Policy In Outpatient Departments: A Survey from Four Thai Hospitals
T2  - Infection control and hospital epidemiology
TI  - Patients' Anxiety, Fear and Panic for COVID-19 and Confidence in Hospital Infection Control Policy In Outpatient Departments: A Survey from Four Thai Hospitals
ID  - 7790884
ER  - 

TY  - JOUR
AB  - Background The excessive amount of information (infodemic) about SARS-COV2 is a global challenge for healthcare authorities in tackling misinformation Aim of the study was to investigate SARS-COV2 global and Italian web search amount made through a reliable information source during 2019-20 SARS-COV2 epidemic Methods From December 15th, 2019 to February 23rd, 2020, we used Google Trends to analyze global changes in the volume of searches about “Coronavirus�?in relation to reliable sources: “World Health Organization�? “WHO�?and the Italian equivalents of “Ministry of Health�?and “National Institute of Health�?Primary searches and associated queries (AQs) were analyzed by nation and Italian Region Results Global interest on “Coronavirus�?progressively rose from mid-January, with 2 peaks on days 28th and 31st, fell on February 20th and rose again until day 23rd “WHO�?searches fluctuated with no clear pattern but increased on January 26th and February 3rd &#039;WHO&#039; term was among the most frequent “Coronavirus�?AQs and viceversa Singapore, Italy and New Zealand were the most interested nations in “Coronavirus�? while China was at first place in “Coronavirus+WHO�?searches In Italy from January 21st interest in “Coronavirus�?gradually increased, with peaks on days 28th and 31st and a higher peak on February 21st The other terms showed a fluctuating trend, with peaks on January 31st for “WHO�?and “Ministry of Health�?and on February 21st for all of them “Coronavirus�?was most frequently AQ to “Italy�?and “China�? while AQs for the other terms were “Coronavirus�?and “WHO official website�?The most interested Italian Regions for “Coronavirus�?and “Coronavirus+WHO�?were Lazio and Friuli Venezia-Giulia, respectively Conclusions Interest in SARS-COV2 globally increased during the considered period, especially within most affected areas The associations between terms thus highlighted seems to confirm that the general population relies on trustworthy information sources Key messages Infodemic can be at the same time a danger and an opportunity during global and local health emergencies Health systems should take advantage of current search flow in order to foster reliable information sharing
AU  - Antinolfi, F.
AU  - Brunelli, L.
AU  - Cocconi, R.
AU  - Brusaferro, S.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Infodemic: analysis of global and local 2019-20 Coronavirus epidemic search flow
T2  - European Journal of Public Health
TI  - Infodemic: analysis of global and local 2019-20 Coronavirus epidemic search flow
UR  - https://doi.org/10.1093/eurpub/ckaa166.053
ID  - 7792908
ER  - 

TY  - JOUR
AU  - Anthony Jnr, Bokolo
AU  - Abbas Petersen, Sobah
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Examining the digitalisation of virtual enterprises amidst the COVID-19 pandemic: a systematic and meta-analysis
T2  - Enterprise Information Systems
TI  - Examining the digitalisation of virtual enterprises amidst the COVID-19 pandemic: a systematic and meta-analysis
UR  - https://doi.org/10.1080/17517575.2020.1829075
ID  - 7792946
ER  - 

TY  - JOUR
AN  - 2448457219
AU  - Anonymous
C1  - 10/7/2020
DA  - Oct 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; ProQuest Central
DP  - ProQuest Central
IS  - 10
KW  - Occupational Health And Safety
Pandemics
COVID-19
LA  - English
N1  - Copyright - Copyright American Society of Safety Engineers Oct 2020
PY  - 2020
SN  - 00990027
SP  - 8
ST  - Free Course Provides Information on SAFELY RESUMING OPERATIONS
T2  - Professional Safety
TI  - Free Course Provides Information on SAFELY RESUMING OPERATIONS
UR  - https://www.proquest.com/docview/2448457219?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Free+Course+Provides+Information+on+SAFELY+RESUMING+OPERATIONS&title=Professional+Safety&issn=00990027&date=2020-10-01&volume=65&issue=10&spage=8&au=Anonymous&isbn=&jtitle=Professional+Safety&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 65
ID  - 7789891
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has increased dramatically the demand for hand sanitizers. A major concern is their adulteration with methanol that caused more than 700 fatalities in Iran and U.S.A. (since Feb. 2020). In response, the U.S. Food and Drug Administration (FDA) has restricted the methanol content in hand sanitizers to 0.063 vol% and blacklisted 194 products (as of Oct. 1, 2020). Here, we present a low-cost, handheld and smartphone-assisted device that detects methanol selectively in hand sanitizers between 0.01-100 vol% within two minutes by headspace analysis. It features a nanoporous polymer column that separates methanol from confounders by adsorption (i.e. van-der-Waals forces) rendering it selective. A chemoresistive gas sensor detects the methanol. When tested on seven pure and spiked commercial sanitizers (total 76 samples), methanol was quantified accurately, in excellent (Rsup2/sup = 0.99) agreement to "gold standard" gas chromatography. Most importantly, methanol quantification was hardly interfered by different sanitizer compositions (e.g. 2-propanol, ethanol, butanone, glycerin, aloe vera essence, various odorants and colorants) and gel-like viscosity while other potential contaminants (e.g. 1-propanol) were recognized as well. This device meets an urgent need for distributed and on-site methanol screening by authorities (e.g. customs, police), health product distributers and even laymen. br
AU  - Andreas T., Güntner
AU  - Leandro, Magro
AU  - Jan van den, Broek
AU  - Sotiris E., Pratsinis
C1  - 10/7/2020
DB  - chemRxiv
DO  - 10.26434/chemrxiv.13058195.v1
DP  - chemRxiv
KW  - Public health
Disinfectants
Chemical detection
SARS-CoV-2
Hazardous material monitoring
PY  - 2020
ST  - Sniffing Methanol in Hand Sanitizers (preprint)
T2  - chemRxiv
TI  - Sniffing Methanol in Hand Sanitizers (preprint)
UR  - https://chemrxiv.org/articles/preprint/Sniffing_Methanol_in_Hand_Sanitizers/13058195
ID  - 7794783
ER  - 

TY  - JOUR
AU  - Anderson, Stephen
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 and Leisure in the United States
T2  - World Leisure Journal
TI  - COVID-19 and Leisure in the United States
UR  - https://doi.org/10.1080/16078055.2020.1825259
ID  - 7792950
ER  - 

TY  - JOUR
AB  - Nurses have a unique place in redesigning the future of healthcare, particularly after experiencing health policy failures with the coronavirus disease 2019 pandemic. Nurses consistently outperform other professions to enjoy a decades-long reputation as the most trusted profession. Nevertheless, the nursing voice is missing at a public level; representation in governments and boardrooms negligible. While nurses carry out health policy, rarely are they involved informing policy. While substantial dialog on health system reform, regulatory changes, care coordination, and health information technology occurs, nursing's presence is absent. The barriers are many: a lack of political sophistication, family, and work demands limiting time, and a lack of confidence. Using the Yoder-Wise Framework for Planned Policy Change, opportunities for engagement at each step in the process are made clear. Workplace opportunities provide entry-level representation and exposure to the machinations of governance. Nursing professional associations provide similar opportunities. For many nurses, social media, while not without its risks, offers a familiar and accessible platform by which to engage patients, the public, and policymakers in planned, strategic steps to create policy change and improve healthcare for patients.
AD  - School of Nursing, University of Texas, El Paso, Texas, USA.
AN  - 33022755
AU  - Anders, R. L.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/nuf.12514
DP  - NLM
ET  - 2020/10/07
J2  - Nursing forum
KW  - Coviid-19
action steps to policymaking
barriers to policymaking
executive roles
governance
health policy
nursing empowerment
nursing voice
patient advocacy
policymaking
politics
social media
LA  - eng
N1  - 1744-6198
Anders, Robert L
Orcid: 0000-0002-8714-2663
Journal Article
United States
Nurs Forum. 2020 Oct 6. doi: 10.1111/nuf.12514.
PY  - 2020
SN  - 0029-6473
ST  - Engaging nurses in health policy in the era of COVID-19
T2  - Nursing forum
TI  - Engaging nurses in health policy in the era of COVID-19
ID  - 7790948
ER  - 

TY  - JOUR
AB  - This article explores how ?flatten the curve? (FTC) visualizations have served as a rhetorical anchor for communicating the risk of viral spread during the COVID-19 pandemic Beginning from the premise that risk visualizations have eclipsed their original role as supplemental to public risk messaging and now function as an organizer of discourse, the authors highlight three rhetorical tensions (epideictic?deliberative, global?local, conceptual metaphors?data representations) with the goal of considering how the field of technical and professional communication might more strongly support visual risk literacy in future crises
AU  - Amidon, Timothy R.
AU  - Nielsen, Alex C.
AU  - Pflugfelder, Ehren H.
AU  - Richards, Daniel P.
AU  - Stephens, Sonia H.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Visual Risk Literacy in “Flatten the Curve�?COVID-19 Visualizations
T2  - Journal of Business and Technical Communication
TI  - Visual Risk Literacy in “Flatten the Curve�?COVID-19 Visualizations
UR  - https://doi.org/10.1177/1050651920963439
ID  - 7792817
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic is impacting national and international public health. Routine childhood immunization may be adversely affected by COVID-19 mitigation measures. We aimed to identify the prevalence of delayed immunization and explore the reasons and barriers for delayed immunization during the COVID-19 pandemic in the Qassim region, Saudi Arabia. We conducted a cross-sectional study using an online self-administered questionnaire for parents of children under two years of age during the period from 1 May to 30 June 2020. Most of the 749 participants (82.6%) were mothers, with 31 to 40 years being the most common age group (49.8%). Nearly three-quarters (73.2%) of the parents had appointments scheduled for their child's vaccination during the pandemic, and approximately 23.4% of the parents reported a delay of more than one month in the immunization of their child. The most common reason for the delay was the fear of being infected by COVID-19 (60.9%). Large household size and lack of insurance were risk factors for immunization delay. The COVID-19 pandemic has affected the timeliness of routine childhood immunization in Saudi Arabia. Childhood immunization should be prioritized, as well as the implementation of focused strategies to achieve significant and sustainable vaccination rates during pandemics.
AD  - Department of Pediatrics, College of Medicine, Qassim University, Qassim 51452, Saudi Arabia.
AN  - 33022916
AU  - Alsuhaibani, M.
AU  - Alaqeel, A.
C1  - 10/7/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.3390/vaccines8040581
DP  - NLM
ET  - 2020/10/08
IS  - 4
J2  - Vaccines
KW  - Covid-19
childhood
children
coronavirus
immunizations
vaccinations
vaccine-preventable disease, SARS-CoV-2
LA  - eng
N1  - Alsuhaibani, Mohammed
Orcid: 0000-0003-3181-777x
Alaqeel, Aqeel
Orcid: 0000-0003-1681-5338
Journal Article
Switzerland
Vaccines (Basel). 2020 Oct 3;8(4):E581. doi: 10.3390/vaccines8040581.
PY  - 2020
SN  - 2076-393X (Print)
2076-393x
ST  - Impact of the COVID-19 Pandemic on Routine Childhood Immunization in Saudi Arabia
T2  - Vaccines
TI  - Impact of the COVID-19 Pandemic on Routine Childhood Immunization in Saudi Arabia
VL  - 8
ID  - 7790934
ER  - 

TY  - JOUR
AB  - In this research work, a non-linear dynamical modified SEIR model of the recent pandemic, due to Coronavirus-19 disease (COVID-19) for different countries like Malaysia and Pakistan, is considered under nonsingular fractional order derivative For this model, some qualitative results, existence theory, and numerical solution are studied by using fixed point approach and fractional Adams-Bashforth method The results are simulated corresponding to some real data of various fractional order by using Matlab Hence, the suitability of the considered COVID-19 model for the current outbreak in two different countries Malaysia and Pakistan are shown by simulation
AU  - Alrabaiah, Hussam
AU  - Arfan, Muhammad
AU  - Shah, Kamal
AU  - Mahariq, Ibrahim
AU  - Ullah, Aman
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A Comparative Study of spreading of Novel Corona Virus Disease By Using Fractional Order Modified SEIR Model
T2  - Alexandria Engineering Journal
TI  - A Comparative Study of spreading of Novel Corona Virus Disease By Using Fractional Order Modified SEIR Model
UR  - https://doi.org/10.1016/j.aej.2020.09.036
ID  - 7793256
ER  - 

TY  - JOUR
AU  - Alpar, Paul
AU  - Osterbrink, Lars
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Consequences of the COVID-19 Pandemic for IT Work
T2  - Information Systems Management
TI  - Consequences of the COVID-19 Pandemic for IT Work
UR  - https://doi.org/10.1080/10580530.2020.1820638
ID  - 7792967
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The pandemic of the coronavirus disease 2019 (COVID-19) and associated pneumonia represent a clinical and scientific challenge. The role of Extracorporeal Membrane Oxygenation (ECMO) in such a crisis remains unclear. METHODS: We examined COVID-19 patients who were supported for acute respiratory failure by both conventional mechanical ventilation (MV) and ECMO at a tertiary care institution in Washington DC. The study period extended from March 23 to April 29. We identified 59 patients who required invasive mechanical ventilation. Of those, 13 patients required ECMO. RESULTS: Nine out of 13 ECMO (69.2%) patients were decannulated from ECMO. All-cause ICU mortality was comparable between both ECMO and MV groups (6 patients [46.15%] vs. 22 patients [47.82 %], p�?�?.92). ECMO non-survivors vs survivors had elevated D-dimer (9.740 mcg/ml [4.84-20.00] vs. 3.800 mcg/ml [2.19-9.11], p�?�?.05), LDH (1158 ±�?44.5 units/L vs. 575.9 ±�?24.0 units/L, p�?�?.001), and troponin (0.4315 ±�?.465 ng/ml vs. 0.034 ±�?.043 ng/ml, p�?�?.04). Time on MV as expected was significantly longer in ECMO groups (563.3 hours [422.1-613.9] vs. 247.9 hours [101.8-479] in MV group, p�?�?.0009) as well as ICU length of stay 576.2 hours [457.5-652.8] in ECMO group vs. 322.2 hours [120.6-569.3] in MV group, p�?�?.012). CONCLUSION: ECMO is a supportive intervention for COVID-19 associated pneumonia that could be considered if the optimum mechanical ventilation is deemed ineffective. Biomarkers such as D-dimer, LDH, and troponin could help with discerning the clinical prognosis in patients with COVID-19 pneumonia.
AD  - Department of Medicine, MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Critical Care Medicine, MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Department of Cardiac Surgery, MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
AN  - 33021147
AU  - Alnababteh, M.
AU  - Hashmi, M. D.
AU  - Vedantam, K.
AU  - Chopra, R.
AU  - Kohli, A.
AU  - Hayat, F.
AU  - Kriner, E.
AU  - Molina, E.
AU  - Pratt, A.
AU  - Oweis, E.
AU  - Zaaqoq, A. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0267659120963885
DP  - NLM
ET  - 2020/10/07
J2  - Perfusion
KW  - Ards
Covid-19
Ecmo
LA  - eng
N1  - 1477-111x
Alnababteh, Muhtadi
Orcid: 0000-0001-8521-9260
Hashmi, Muhammad D
Vedantam, Karthik
Chopra, Rajus
Kohli, Akshay
Hayat, Fatima
Kriner, Eric
Molina, Ezequiel
Pratt, Alexandra
Oweis, Emil
Zaaqoq, Akram M
Journal Article
England
Perfusion. 2020 Oct 6:267659120963885. doi: 10.1177/0267659120963885.
PY  - 2020
SN  - 0267-6591
SP  - 267659120963885
ST  - Extracorporeal membrane oxygenation for COVID-19 induced hypoxia: Single-center study
T2  - Perfusion
TI  - Extracorporeal membrane oxygenation for COVID-19 induced hypoxia: Single-center study
ID  - 7791047
ER  - 

TY  - JOUR
AU  - Alimohammadi, Mahmood
AU  - Naderi, Maziar
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Effectiveness of Ozone Gas on Airborne Virus Inactivation in Enclosed Spaces: A Review Study
T2  - Ozone: Science & Engineering
TI  - Effectiveness of Ozone Gas on Airborne Virus Inactivation in Enclosed Spaces: A Review Study
UR  - https://doi.org/10.1080/01919512.2020.1822149
ID  - 7792683
ER  - 

TY  - JOUR
AB  - In this manuscript, a qualitative analysis of the mathematical model of novel coronavirus (COVID-19) involving anew devised fractal-fractional operator in the Caputo sense having the fractional-order q and the fractal dimension p is considered The concerned model is composed of eight compartments: susceptible, exposed, infected, super-spreaders, asymptomatic, hospitalized, recovery and fatality Under the new derivative the existence and uniqueness of the solution for considered model are proved using Schaefer’s and Banach type fixed point approaches Additionally, with the help of nonlinear functional analysis, the condition for Ulam’s type of stability of the solution to the considered model is established For numerical simulation of proposed model, a fractional type of two-step Lagrange polynomial known as fractional Adams-Bashforth (AB) method is applied to simulate the results At last, the results are tested with real data from COVID-19 outbreak in Wuhan City, Hubei Province of China from 4 January to 9 March 2020, taken from a source [42] The Numerical results are presented in terms of graphs for different fractional-order q and fractal dimensions p to describe the transmission dynamics of disease infection
AU  - Ali, Zeeshan
AU  - Rabiei, Faranak
AU  - Shah, Kamal
AU  - Khodadadi, Touraj
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Qualitative Analysis of Fractal-Fractional order COVID-19 Mathematical Model with Case Study of Wuhan
T2  - Alexandria Engineering Journal
TI  - Qualitative Analysis of Fractal-Fractional order COVID-19 Mathematical Model with Case Study of Wuhan
UR  - https://doi.org/10.1016/j.aej.2020.09.020
ID  - 7793257
ER  - 

TY  - JOUR
AB  - Background: COVID-19 virus has been reported as a pandemic in March 2020 by the WHO. Having a balanced and healthy diet routine can help boost the immune system, which is essential in fighting viruses. Public Health officials enforced lockdown for residents resulting in dietary habits change to combat sudden changes. Design and Methods: A cross-sectional study was conducted through an online survey to describe the impact of the COVID-19 pandemic on the eating habits, quality and quantity of food intake among adults in Saudi Arabia. SPSS version 24 was used to analyze the data. Comparison between general dietary habits before and during COVID-19 for ordinal variables was performed by Wilcoxon Signed Rank test, while McNemar test was performed for nominal variables. The paired samples t-test was used to compare the total scores for food quality and quantity before and during COVID-19 periods. Results: 2706 adults residing in Riyadh completed the survey. The majority (85.6%) of the respondents reported eating homecooked meals on a daily basis during COVID-19 as compared to 35.6% before (p0.001). The mean score for the quality of food intake was slightly higher (p=0.002) before the COVID-19 period (16.46�u2.84) as compared to the during period (16.39�u2.79). The quantity of food mean score was higher (p0.001) during the COVID-19 period (15.70�u2.66) as compared to the before period (14.62�u2.71). Conclusion: Dietary habits have changed significantly during the COVID-19 pandemic among Riyadh residents. Although some good habits increased, the quality and the quantity of the food was compromised. Public Health officials must focus on increased awareness on healthy eating during pandemics to avoid negative consequences. Future research is recommended to better understand the change in dietary habits during pandemics using a detailed food frequency questionnaire.
AD  - College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
AN  - 33024727
AU  - Alhusseini, N.
AU  - Alqahtani, A.
C1  - 10/7/2020
C2  - PMC7512943
DA  - Jul 28
DB  - PubMed
DO  - 10.4081/jphr.2020.1868
DP  - NLM
ET  - 2020/10/08
IS  - 3
J2  - Journal of public health research
KW  - Covid-19
dietary habits
food quality
food quantity
pandemic
LA  - eng
N1  - Alhusseini, Noara
Alqahtani, Abdulrahman
Journal Article
Italy
J Public Health Res. 2020 Sep 16;9(3):1868. doi: 10.4081/jphr.2020.1868. eCollection 2020 Jul 28.
PY  - 2020
SN  - 2279-9028 (Print)
2279-9028
SP  - 1868
ST  - COVID-19 pandemic's impact on eating habits in Saudi Arabia
T2  - Journal of public health research
TI  - COVID-19 pandemic's impact on eating habits in Saudi Arabia
VL  - 9
ID  - 7790774
ER  - 

TY  - JOUR
AB  - As the Coronavirus Disease 2019 (COVID-19), which is caused by the novel SARS-CoV-2, continues to spread rapidly around the world, there is a need for well validated serological assays that allow the detection of viral specific antibody responses in COVID-19 patients or recovered individuals. In this study, we established and used multiple indirect Enzyme Linked Immunosorbent Assay (ELISA)-based serological assays to study the antibody response in COVID-19 patients. In order to validate the assays we determined the cut off values, sensitivity and specificity of the assays using sera collected from pre-pandemic healthy controls, COVID-19 patients at different time points after disease-onset, and seropositive sera to other human coronaviruses (CoVs). The developed SARS-CoV-2 S1 subunit of the spike glycoprotein and nucleocapsid (N)-based ELISAs not only showed high specificity and sensitivity but also did not show any cross-reactivity with other CoVs. We also show that all RT-PCR confirmed COVID-19 patients tested in our study developed both virus specific IgM and IgG antibodies as early as week one after disease onset. Our data also suggest that the inclusion of both S1 and N in serological testing would capture as many potential SARS-CoV-2 positive cases as possible than using any of them alone. This is specifically important for tracing contacts and cases and conducting large-scale epidemiological studies to understand the true extent of virus spread in populations.
AD  - Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Medical Laboratories Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Medical Research Center, Jazan University, Jazan, Saudi Arabia.
Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
Pathogen Genomics Laboratory, Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology, Thuwa, Saudi Arabia.
King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Jeddah, Saudi Arabia.
Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Biology, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Infectious Diseases Department, King Abdullah Medical Complex, Jeddah, Saudi Arabia.
Infectious Diseases Department, King Fahad Hospital, Almadinah Almunwarah, Saudi Arabia.
Plan and Research Department, General Directorate of Health Affairs Makkah Region, Ministry of Health, Makkah, Saudi Arabia.
Department of Medical Laboratory Technology, University of Tabuk, Tabuk, Saudi Arabia.
College of Applied Medical Sciences, Taibah University, Almadinah Almunwarah, Saudi Arabia.
Center for Genetics and Inherited Diseases, Taibah University, Almadinah Almunwarah, Saudi Arabia.
Research Center for Zoonosis Control, Hokkaido University, Kita-ku, Sapporo, Japan.
Nuffield Division of Clinical Laboratory Sciences (NDCLS), University of Oxford, Oxford, UK.
Vaccines and Immunotherapy Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia. amhashem@kau.edu.sa.
Department of Medical Microbiology and Parasitology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. amhashem@kau.edu.sa.
AN  - 33024213
AU  - Algaissi, A.
AU  - Alfaleh, M. A.
AU  - Hala, S.
AU  - Abujamel, T. S.
AU  - Alamri, S. S.
AU  - Almahboub, S. A.
AU  - Alluhaybi, K. A.
AU  - Hobani, H. I.
AU  - Alsulaiman, R. M.
AU  - AlHarbi, R. H.
AU  - ElAssouli, M. A.
AU  - Alhabbab, R. Y.
AU  - AlSaieedi, A. A.
AU  - Abdulaal, W. H.
AU  - Al-Somali, A. A.
AU  - Alofi, F. S.
AU  - Khogeer, A. A.
AU  - Alkayyal, A. A.
AU  - Mahmoud, A. B.
AU  - Almontashiri, N. A. M.
AU  - Pain, A.
AU  - Hashem, A. M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1038/s41598-020-73491-5
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Algaissi, Abdullah
Alfaleh, Mohamed A
Hala, Sharif
Abujamel, Turki S
Alamri, Sawsan S
Almahboub, Sarah A
Alluhaybi, Khalid A
Hobani, Haya I
Alsulaiman, Reem M
AlHarbi, Rahaf H
ElAssouli, M-Z Aki
Alhabbab, Rowa Y
AlSaieedi, Ahdab A
Abdulaal, Wesam H
Al-Somali, Afrah A
Alofi, Fadwa S
Khogeer, Asim A
Alkayyal, Almohanad A
Mahmoud, Ahmad Bakur
Almontashiri, Naif A M
Pain, Arnab
Orcid: 0000-0002-1755-2819
Hashem, Anwar M
Orcid: 0000-0002-8471-7011
Journal Article
England
Sci Rep. 2020 Oct 6;10(1):16561. doi: 10.1038/s41598-020-73491-5.
PY  - 2020
SN  - 2045-2322
SP  - 16561
ST  - SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients
T2  - Scientific reports
TI  - SARS-CoV-2 S1 and N-based serological assays reveal rapid seroconversion and induction of specific antibody response in COVID-19 patients
VL  - 10
ID  - 7790833
ER  - 

TY  - JOUR
AB  - A simple reordering of the reaction sequence allowed the improved synthesis of EIDD-2801, an antiviral with promising activity against the SARS-CoV-2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17% to 61%, and fewer isolation/purification steps were needed. In addition, a continuous flow procedure for the final acetonide deprotection was developed, which proved to be favorable toward selectivity and reproducibility.br
AU  - Alexander, Steiner
AU  - Desiree, Znidar
AU  - S֙ndor B., Ötvös
AU  - David R., Snead
AU  - Doris, Dallinger
AU  - C. Oliver, Kappe
C1  - 10/7/2020
DB  - chemRxiv
DO  - 10.26434/chemrxiv.13058486.v1
DP  - chemRxiv
KW  - EIDD-2801
COVID-19
continuous flow
acetonide deprotection
triazolation
PY  - 2020
ST  - A High-Yielding Synthesis of EIDD-2801 from Uridine (preprint)
T2  - chemRxiv
TI  - A High-Yielding Synthesis of EIDD-2801 from Uridine (preprint)
UR  - https://chemrxiv.org/articles/preprint/A_High-Yielding_Synthesis_of_EIDD-2801_from_Uridine/13058486
ID  - 7794784
ER  - 

TY  - JOUR
AB  - Background During pandemics, healthcare workers (HCWs) may be prone to higher levels of anxiety than those of the general population This study aimed to explore the anxiety levels among HCWs in Saudi Arabia during the COVID-19 pandemic and the predictors of increased anxiety levels Method HCW participants in this cross-section study were solicited by email from the database of registered practitioners of the Saudi Commission for Health Specialties between 15 May and 18 May 2020 Sociodemographic characteristics, work-related factors, and organization-related factors were collected Results Four thousand nine hundred and twenty HCWs (3 4%) responded Reported levels of anxiety were low anxiety (31 5%;n = 1552), medium (36 1%;n = 1778), and high (32 3%;n = 1590) Participants reporting high anxiety levels were more likely to be unmarried (OR = 1 32, 95% CI: 1 14�? 52);nurses (OR = 1 54, 95% 1 24�? 91);workers in radiology (OR = 1 52, 95% CI: 1 01�? 28);or respiratory therapists (OR = 2 28, 95% CI: 1 14�? 54) Social factors associated with high anxiety levels were: living with a person who is elderly (p = 0 01), has a chronic disease (p &amp;lt; 0 0001), has immune deficiency (p &amp;lt; 0 0001), or has a respiratory disease (p-value &amp;lt;0 0001) Organization-related factors associated with a high level of anxiety were: working in an organization that hosts COVID-19 patients and working with such patients (p-value &amp;lt;0 0001) Conclusion Self-reported medium and high levels of anxiety were present in 68 5% of HCWs in the COVID-19 pandemic This highlights the urgent need to identify high-risk individuals to offer psychological support and provide up to date information on the pandemic These data should help policymakers drive initiatives forward to protect and prepare HCWs psychological wellbeing
AU  - Alenazi, Thamer H.
AU  - BinDhim, Nasser F.
AU  - Alenazi, Meteb H.
AU  - Tamim, Hani
AU  - Almagrabi, Reem S.
AU  - Aljohani, Sameera M.
AU  - H Basyouni, Mada
AU  - Almubark, Rasha A.
AU  - Althumiri, Nora A.
AU  - Alqahtani, Saleh A.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Prevalence and predictors of anxiety among healthcare workers in Saudi Arabia during the COVID-19 pandemic
T2  - Journal of Infection and Public Health
TI  - Prevalence and predictors of anxiety among healthcare workers in Saudi Arabia during the COVID-19 pandemic
UR  - https://doi.org/10.1016/j.jiph.2020.09.001
ID  - 7793128
ER  - 

TY  - JOUR
AU  - Alanen, Leena
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A relational challenge to post-corona childhood studies
T2  - Childhood
TI  - A relational challenge to post-corona childhood studies
UR  - https://doi.org/10.1177/0907568220945544
ID  - 7792828
ER  - 

TY  - JOUR
AB  - Background: Coronavirus disease 2019 (COVID-19) has been associated with a coagulopathy giving rise to venous and arterial thrombotic events. The objective of our study was to determine whether markers of coagulation and hemostatic activation (MOCHA) on admission could identify COVID-19 patients at risk for thrombotic events and other complications. Methods: COVID-19 patients admitted to a tertiary academic healthcare system from April 3, 2020 to July 31, 2020 underwent standardized admission testing of MOCHA profile parameters (plasma d-dimer, prothrombin fragment 1.2, thrombin-antithrombin complex, and fibrin monomer) with abnormal MOCHA defined as �?2 markers above the reference. Prespecified thrombotic endpoints included deep vein thrombosis, pulmonary embolism, myocardial infarction, ischemic stroke, and access line thrombosis; other complications included ICU admission, intubation and mortality. We excluded patients on anticoagulation therapy prior to admission and those who were pregnant. Results: Of 276 patients (mean age 59 �u 6.4 years, 47% female, 62% African American race) who met study criteria, 45 (16%) had a thrombotic event. Each coagulation marker on admission was independently associated with a vascular endpoint (p&amp;lt;0.05). Admission MOCHA with �?2 abnormalities (n=203, 74%) was associated with in-hospital vascular endpoints (OR 3.3, 95% CI 1.2-8.8), as were admission D-dimer �?2000 ng/mL (OR 3.1, 95% CI 1.5-6.6), and admission D-dimer �?3000 ng/mL (OR 3.6, 95% CI 1.6-7.9). However, only admission MOCHA with �?2 abnormalities was associated with ICU admission (OR 3.0, 95% CI 1.7-5.2) and intubation (OR 3.2, 95% CI 1.6-6.4), while admission D-dimer �?2000 ng/mL and admission D-dimer �?3000 ng/mL were not associated. MOCHA and D-dimer cutoffs were not associated with mortality. Admission MOCHA with &amp;lt;2 abnormalities (26% of the cohort) had a sensitivity of 88% and negative predictive value of 93% for a vascular endpoint. Conclusions: Admission MOCHA with �?2 abnormalities identified COVID-19 patients at increased risk of ICU admission and intubation during hospitalization more effectively than isolated admission D-dimer measurement. Admission MOCHA with &amp;lt;2 abnormalities identified a subgroup of patients at low risk for vascular events. Our results suggest that an admission MOCHA profile can be useful to risk-stratify COVID-19 patients.Competing Interest StatementDr. Nahab has a patent on the use of the MOCHA profile to guide medical treatment in cardiovascular disease and stroke.Funding StatementNo external funding was received for this study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Emory University IRB approved this study.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data is available for approved requests made to the corresponding author.
AU  - Alabyad, Darwish
AU  - Rangaraju, Srikant
AU  - Liu, Michael
AU  - Imran, Rajeel
AU  - Kempton, Christine
AU  - Sharifpour, Milad
AU  - Auld, Sara
AU  - Gaddh, Manila
AU  - Sniecinski, Roman
AU  - Maier, Cheryl L.
AU  - Guarner, Jeannette
AU  - Duncan, Alexander
AU  - Nahab, Fadi
C1  - 10/7/2020
DB  - medRxiv
DO  - 10.1101/2020.10.04.20206540
DP  - medRxiv
PY  - 2020
SP  - 2020.10.04.20206540
ST  - Markers Of Coagulation And Hemostatic Activation Identify COVID-19 Patients At High Risk For Thrombotic Events, ICU Admission and Intubation (preprint)
T2  - medRxiv
TI  - Markers Of Coagulation And Hemostatic Activation Identify COVID-19 Patients At High Risk For Thrombotic Events, ICU Admission and Intubation (preprint)
UR  - http://medrxiv.org/content/early/2020/10/06/2020.10.04.20206540.abstract
ID  - 7794775
ER  - 

TY  - JOUR
AB  - BACKGROUND: Patients with established cardiovascular diseases have a poor prognosis when affected by the coronavirus disease 2019 (COVID-19). Also, the cardiovascular system, especially the heart, is affected by COVID-19. So we aimed to evaluate the angiographic and clinical characteristics of COVID-19 patients presented by ST-elevation myocardial infarction (STEMI). RESULTS: Our retrospective study showed that STEMI patients with COVID-19 had elevated inflammatory markers with mean of their CRP (89.69 �u 30.42 mg/dl) and increased laboratory parameters of thrombosis with mean D-dimer (660.15 �u 360.11 ng/ml). In 69.2% of patients, STEMI was the first clinical presentation and symptoms suggestive of COVID-19 developed during the hospital stay; about one third of patients had a non-obstructive CAD, while patients with total occlusion had a high thrombus burden. CONCLUSION: STEMI may be the initial presentation of COVID-19. A non-obstructive CAD was found in about one third of patients; on the other hand, in patients who had a total occlusion of their culprit artery, the thrombus burden was high. Identification of the underlying mechanism responsible for the high thrombus burden in these patients is important as it may result in changes in their primary management strategy, either primary PCI, fibrinolytic therapy, or a pharmaco-invasive strategy. Furthermore, adjunctive anticoagulation and antiplatelet therapy may need to be revised.
AD  - Department of Cardiology, Tanta University, Tanta, Egypt. a_f_elarag@yahoo.com.
Department of Cardiology, Tanta University, Tanta, Egypt.
AN  - 33025310
AU  - Alaarag, A.
AU  - Hassan, T.
AU  - Samir, S.
AU  - Naseem, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1186/s43044-020-00103-y
DP  - NLM
ET  - 2020/10/08
IS  - 1
J2  - The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology
KW  - Covid-19
High thrombus burden
Primary PCI
Stemi
TIMI flow
LA  - eng
N1  - 2090-911x
Alaarag, Ahmed
Orcid: 0000-0002-6596-4834
Hassan, Timoor
Samir, Sameh
Naseem, Mohamed
Journal Article
Germany
Egypt Heart J. 2020 Oct 6;72(1):68. doi: 10.1186/s43044-020-00103-y.
PY  - 2020
SN  - 1110-2608
SP  - 68
ST  - Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital
T2  - Egyptian heart journal : (EHJ) : official bulletin of Egyptian Society of Cardiology
TI  - Clinical and angiographic characteristics of patients with STEMI and confirmed diagnosis of COVID-19: an experience of Tanta University Hospital
VL  - 72
ID  - 7790714
ER  - 

TY  - JOUR
AB  - A new virus pandemic, COVID-19, has instigated substantial damage to human wellness in terms of death and ailment, economic compromises along with restriction of daily routine life. There is a profound increase in the number of victims and causalities day by day. Thus far, there is no available treatment and vaccination for COVID-19. Under the rapid pace of clinical research work, scientists have reported different drugs having in vitro efficacy against COVID-19. But the evidences for their in vivo use have not been established yet in terms of clinical effect, duration of stay in intensive care units as well as the refuge of these drugs and their combinations. Anti-retroviral, Remdesivir, as well as different repurposed drugs like chloroquine and hydroxychloroquine have shown promising effects in vitro. Numerous clinical tests are underway in order to explore the benefits of these drugs. This review covers the disease pathogenesis and various potential targets with reference to the virulence of COVID-19.
AD  - Department of Pharmacy, University of Agriculture, Faisalabad,. Pakistan.
Institute of Physiology and Pharmacology, University of Agriculture, Faisalabad,. Pakistan.
Institute of Pharmacy, Faculty of Pharmaceutical and Allied Health Sciences, Lahore College for Women University Jail Road Lahore,. Pakistan.
AN  - 33023432
AU  - Akhtar, B.
AU  - Muhammad, F.
AU  - Sharif, A.
AU  - Hannan, A.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.2174/1389450121999201006193329
DP  - NLM
ET  - 2020/10/08
J2  - Current drug targets
KW  - Covid-19
Chloroquine
Clinical trials
Pneumonia
Potential targets
Remdisivir
LA  - eng
N1  - 1873-5592
Akhtar, Bushra
Muhammad, Faqir
Sharif, Ali
Hannan, Abdul
Journal Article
United Arab Emirates
Curr Drug Targets. 2020 Oct 6. doi: 10.2174/1389450121999201006193329.
PY  - 2020
SN  - 1389-4501
ST  - Therapeutic Options for Treatment of COVID-19: A Review from Repur-posed Drugs to New Drug Targets
T2  - Current drug targets
TI  - Therapeutic Options for Treatment of COVID-19: A Review from Repur-posed Drugs to New Drug Targets
ID  - 7790912
ER  - 

TY  - JOUR
AB  - The novel coronavirus (SARS-CoV-2) has turned into a life-threatening pandemic disease (Covid-19). About 5% of patients with Covid-19 have severe symptoms including septic shock, acute respiratory distress syndrome, and the failure of several organs, while most of them have mild symptoms. Frequently, the kidneys are involved through direct or indirect mechanisms. Kidney involvement mainly manifests itself as proteinuria and acute kidney injury (AKI). The SARS-CoV-2-induced kidney damage is expected to be multifactorial; directly it can infect the kidney podocytes and proximal tubular cells and based on an angiotensin-converting enzyme 2 (ACE2) pathway it can lead to acute tubular necrosis, protein leakage in Bowman's capsule, collapsing glomerulopathy and mitochondrial impairment. The SARS-CoV-2-driven dysregulation of the immune responses including cytokine storm, macrophage activation syndrome, and lymphopenia can be other causes of the AKI. Organ interactions, endothelial dysfunction, hypercoagulability, rhabdomyolysis, and sepsis are other potential mechanisms of AKI. Moreover, lower oxygen delivery to kidney may cause an ischaemic injury. Understanding the fundamental molecular pathways and pathophysiology of kidney injury and AKI in Covid-19 is necessary to develop management strategies and design effective therapies.
AD  - Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Clinical Research Development Unit, Sina Educational, Research and Treatment Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Surgery, University of Illinois at Chicago-Metropolitan Group Hospitals (UIC-MGH), Chicago, Illinois, USA.
AN  - 33022818
AU  - Ahmadian, E.
AU  - Hosseiniyan Khatibi, S. M.
AU  - Razi Soofiyani, S.
AU  - Abediazar, S.
AU  - Shoja, M. M.
AU  - Ardalan, M.
AU  - Zununi Vahed, S.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/rmv.2176
DP  - NLM
ET  - 2020/10/07
J2  - Reviews in medical virology
KW  - SARS-CoV-2
acute kidney injury
angiotensin
bardikinin
coronovirus
proteinuria
renal injury
LA  - eng
N1  - 1099-1654
Ahmadian, Elham
Hosseiniyan Khatibi, Seyed Mahdi
Razi Soofiyani, Saiedeh
Abediazar, Sima
Shoja, Mohammadali M
Ardalan, Mohammadreza
Zununi Vahed, Sepideh
Orcid: 0000-0003-0179-4562
Kidney Research Center, Tabriz University of Medical Sciences, Tabriz, Iran/
Journal Article
England
Rev Med Virol. 2020 Oct 6:e2176. doi: 10.1002/rmv.2176.
PY  - 2020
SN  - 1052-9276
SP  - e2176
ST  - Covid-19 and kidney injury: Pathophysiology and molecular mechanisms
T2  - Reviews in medical virology
TI  - Covid-19 and kidney injury: Pathophysiology and molecular mechanisms
ID  - 7790939
ER  - 

TY  - JOUR
AU  - Ahmad, Zohaib
AU  - Ahad, Arzoo
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19: A Study of Islamic and Scientific Perspectives
T2  - Theology and Science
TI  - COVID-19: A Study of Islamic and Scientific Perspectives
UR  - https://doi.org/10.1080/14746700.2020.1825192
ID  - 7792955
ER  - 

TY  - JOUR
AN  - PMC7536172
AU  - Ahmad, Farrukh
C1  - 10/7/2020
DB  - PMC
DO  - 10.1016/j.mehy.2020.110331
DP  - NLM
J2  - Med Hypotheses
LA  - eng
N1  - PMC7536172[pmcid]
S0306-9877(20)31920-4[PII]
PY  - 2020
SN  - 0306-9877
1532-2777
SP  - 110331
ST  - COVID-19 induced ARDS , and the use of Galantamine to activate the Cholinergic Anti-inflammatory pathway
T2  - Medical Hypotheses
TI  - COVID-19 induced ARDS , and the use of Galantamine to activate the Cholinergic Anti-inflammatory pathway
UR  - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7536172/
ID  - 7790678
ER  - 

TY  - JOUR
AB  - During this coronavirus disease-19 (COVID-19) pandemic, all the countries are emphasizing on procurement of more and more sophisticated machineries for the intensive care unit (ICU) like ventilators. But do all countries have to follow the same? The requirements are different for low- and middle-income countries like India, which are resource limited. The ventilators require oxygen supply and manpower to function which are deficient in these countries. These countries might do well only by procurement of oxygen delivery machinery, as most of the patients of COVID require oxygen only. Only approx. Five percent of COVID-19 patients require ventilators. Moreover, the patients on ventilators have high mortality. Thus, low-resource countries need to redefine their priority as to how to utilize their resources. This manuscript emphasizes the need for the same. HOW TO CITE THIS ARTICLE: Aggarwal R, Trikha A. Acquiring Ventilators: Fighter Planes without High-octane Fuel and Pilots: Indian Perspective in COVID Era. Indian J Crit Care Med 2020;24(8):735-736.
AD  - Department of Critical and Intensive Care, JPN Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
Department of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, New Delhi, India.
AN  - 33024388
AU  - Aggarwal, R.
AU  - Trikha, A.
C1  - 10/7/2020
C2  - PMC7519605
DA  - Aug
DB  - PubMed
DO  - 10.5005/jp-journals-10071-23525
DP  - NLM
ET  - 2020/10/08
IS  - 8
J2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
KW  - Covid-19
Oxygen supply
Ventilator
LA  - eng
N1  - Aggarwal, Richa
Trikha, Anjan
Journal Article
India
Indian J Crit Care Med. 2020 Aug;24(8):735-736. doi: 10.5005/jp-journals-10071-23525.
PY  - 2020
SN  - 0972-5229 (Print)
0972-5229
SP  - 735-736
ST  - Acquiring Ventilators: Fighter Planes without High-octane Fuel and Pilots: Indian Perspective in COVID Era
T2  - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine
TI  - Acquiring Ventilators: Fighter Planes without High-octane Fuel and Pilots: Indian Perspective in COVID Era
VL  - 24
ID  - 7790804
ER  - 

TY  - JOUR
AB  - PURPOSE: To determine the impact of the Coronavirus disease-2019 (COVID-19) pandemic on the volume, indications, and results of CT heads performed in the emergency department (ED) at Canadian tertiary academic centers in Ontario. METHODS: A retrospective review of consecutive CT head examinations ordered through the ED during the early stages of the COVID-19 pandemic in Canada (March 12-April 8, 2020) was performed and compared with that during the pre-COVID-19 period (February 12-March 10, 2020). CT reports were reviewed for the exam indication and the presence of predefined acute findings. A two-sample t test was utilized to compare the cohorts. Daily averages were calculated for all measures to control for the sample size difference between each period. A p value  0.05 was considered significant. RESULTS: Of the total 751 CT head reports, 290 (38.6%) were ordered during the pandemic and 461 (61.4%) were ordered pre-pandemic. The average daily volume of CT head orders decreased significantly during COVID-19 compared with that during pre-COVID-19 (10.4 scans/day vs 16.5 scans/day; p = 0.001). In terms of indications, the frequency of "non-traumatic ICH" was significantly lower during COVID-19 compared with that during pre-COVID-19 (p = 0.01). Also, there was a significant increase in acute findings on CT during COVID-19 compared with that during pre-COVID-19 (p = 0.001). CONCLUSION: The decreased volume of emergency CT heads performed during the COVID-19 pandemic was associated with a significant increase in the proportion of cases with acute findings. This could be a result of the pandemic's influence on the health-seeking behavior of patients as well as the decision-making process of ordering clinicians.
AD  - Department of Radiology, Hamilton Health Sciences, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada.
Department of Radiology, McMaster University, Hamilton, Canada.
St. Joseph's Healthcare Hamilton, Hamilton, Canada.
Undergraduate Studies, Health Sciences, University of Ottawa, Ottawa, Canada.
Hamilton Niagara Haldimand Brant Regional Cancer Program, Hamilton, Canada.
Department of Radiology, Hamilton Health Sciences, 711 Concession Street, Hamilton, ON, L8V 1C3, Canada. ramonas@hhsc.ca.
Department of Radiology, McMaster University, Hamilton, Canada. ramonas@hhsc.ca.
Department of Diagnostic Imaging, Juravinski Hospital and Cancer Centre, Hamilton Health Sciences, 711 Concession Street, Hamilton, Ontario, L8V 1C3, Canada. ramonas@hhsc.ca.
AN  - 33025216
AU  - Agarwal, M.
AU  - Udare, A.
AU  - Alabousi, A.
AU  - van der Pol, C. B.
AU  - Ramonas, L.
AU  - Mascola, K.
AU  - Edmonds, B.
AU  - Ramonas, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s10140-020-01857-3
DP  - NLM
ET  - 2020/10/08
J2  - Emergency radiology
KW  - CT head
Coronavirus
Diagnostic tests
Emergency service
Head
Hospital
Pandemics
Routine
Tomography
X-ray computed
LA  - eng
N1  - 1438-1435
Agarwal, Minu
Udare, Amar
Alabousi, Abdullah
van der Pol, Christian B
Ramonas, Lucas
Mascola, Ken
Edmonds, Britney
Ramonas, Milita
Orcid: 0000-0002-4491-2816
Journal Article
United States
Emerg Radiol. 2020 Oct 6. doi: 10.1007/s10140-020-01857-3.
PY  - 2020
SN  - 1070-3004
ST  - Impact of the COVID-19 pandemic on emergency CT head utilization in Ontario-an observational study of tertiary academic hospitals
T2  - Emergency radiology
TI  - Impact of the COVID-19 pandemic on emergency CT head utilization in Ontario-an observational study of tertiary academic hospitals
ID  - 7790720
ER  - 

TY  - JOUR
AB  - We performed a cross-sectional survey of infection preventionists in 60 US community hospitals between April 22 and May 8, 2020, and found several differences in hospital preparedness for SARS-CoV-2 with respect to personal protective equipment conservation strategies, protocols related to testing, universal masking and restarting elective procedures.
AD  - Duke Center for Antimicrobial Stewardship and Infection Prevention, Durham, NC.
Duke University School of Medicine, Department of Internal Medicine, Durham, NC.
AN  - 33023688
AU  - Advani, S. D.
AU  - Baker, E.
AU  - Cromer, A.
AU  - Wood, B.
AU  - Crawford, K. L.
AU  - Crane, L.
AU  - Adcock, L.
AU  - Roach, L.
AU  - Padgette, P.
AU  - Anderson, D. J.
AU  - Sexton, D. J.
C1  - 10/7/2020
DA  - Oct 7
DB  - PubMed
DO  - 10.1017/ice.2020.1238
DP  - NLM
ET  - 2020/10/08
J2  - Infection control and hospital epidemiology
KW  - Covid-19
Ppe
SARS-CoV-2
community hospitals
preparedness
resources
LA  - eng
N1  - 1559-6834
Advani, Sonali D
Orcid: 0000-0001-5162-6482
Baker, Esther
Cromer, Andrea
Wood, Brittain
Crawford, Kathryn L
Crane, Linda
Adcock, Linda
Roach, Linda
Padgette, Polly
Anderson, Deverick J
Sexton, Daniel J
CDC Prevention Epicenter Program
Journal Article
United States
Infect Control Hosp Epidemiol. 2020 Oct 7:1-16. doi: 10.1017/ice.2020.1238.
PY  - 2020
SN  - 0899-823x
SP  - 1-16
ST  - Assessing SARS-CoV-2 Preparedness in US Community Hospitals: A Forgotten Entity
T2  - Infection control and hospital epidemiology
TI  - Assessing SARS-CoV-2 Preparedness in US Community Hospitals: A Forgotten Entity
ID  - 7790886
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The world population is under the grip of global pandemic of COVID-19. The present study analyzed relationship between meteorological parameters and COVID-19 in three major cities of Pakistan, i.e., Karachi, Lahore, and Peshawar. METHODS: The impacts of Heat index (HI) and Ultraviolet index (UVI) over daily COVID-19 cases have examined to identify its transmission and propagation. The significance of basic reproductive number (R0), growth rate (Gr) and doubling time (Td) of COVID-19 with HI and UVI was determined. RESULTS: Both indices show a significant positive correlation (at 5% significance level) to R0, Td and Gr of COVID-19 patients. Our results showed that the minimum threshold temperature of 33��C for HI (with a positive variation of 3 to 5��C) put a significant impact on new cases. CONCLUSION: HI and UVI impacted significantly to decline COVID-19 cases over the region.
AD  - Pakistan Meteorological Department, Pitas Bukhari Road, Sector H-8/2, Islamabad-44000, Pakistan (Adnan, Hanif, Khan, Bashir, Kamil, Haider), Department of Meteorology, COMSATS University Islamabad, Chak Shazad, Park road, Islamabad, Pakistan (Latif, Ullah).
AN  - 33021515
AU  - Adnan, S.
AU  - Hanif, M.
AU  - Khan, A. H.
AU  - Latif, M.
AU  - Ullah, K.
AU  - Bashir, F.
AU  - Kamil, S.
AU  - Haider, S.
C1  - 10/7/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1097/jom.0000000000002039
DP  - NLM
ET  - 2020/10/07
J2  - Journal of occupational and environmental medicine
LA  - eng
N1  - 1536-5948
Adnan, Shahzada
Hanif, Muhammad
Khan, Azmat Hayat
Latif, Muhammad
Ullah, Kalim
Bashir, Furrukh
Kamil, Shahzad
Haider, Sajjad
Journal Article
United States
J Occup Environ Med. 2020 Oct 5. doi: 10.1097/JOM.0000000000002039.
PY  - 2020
SN  - 1076-2752
ST  - Impact of Heat Index and Ultraviolet Index on COVID-19 in Major Cities of Pakistan
T2  - Journal of occupational and environmental medicine
TI  - Impact of Heat Index and Ultraviolet Index on COVID-19 in Major Cities of Pakistan
ID  - 7791024
ER  - 

TY  - JOUR
AB  - Resumen Introducci�Qn: estudios recientes han reportado la ocurrencia de fen�Qmenos tromb�Qticos o coagulopat�Ta en pacientes con COVID-19 Hay posiciones divergentes en cuanto a la prevenci�Qn, el diagn�Qstico y el tratamiento de estos fen�Qmenos, y la pr֙ctica cl�Tnica actual est֙ basada únicamente en deducciones por extensi�Qn a partir de estudios retrospectivos, series de casos, estudios observacionales y gu�Tas internacionales desarrolladas previas a la pandemia Objetivo: establecer un grupo de recomendaciones sobre prevenci�Qn, diagn�Qstico y manejo de las complicaciones tromb�Qticas asociadas a COVID-19 Métodos: se desarroll�Q una gu�Ta r֙pida en la que se aplic�Q el marco de la evidencia a la decisi�Qn (EtD) de GRADE y un sistema de participaci�Qn iterativo, con an֙lisis estad�Tsticos y cualitativos de sus resultados Resultados: se generaron 31 recomendaciones cl�Tnicas enfocadas a: a) Pruebas de coagulaci�Qn en adultos sintom֙ticos con sospecha de infecci�Qn o infecci�Qn confirmada por SARS-CoV-2;b) Tromboprofilaxis en personas adultas con diagn�Qstico de COVID-19 (escalas de riesgo, tromboprofilaxis de manejo ambulatorio, intrahospitalario y duraci�Qn de tromboprofilaxis después del egreso de hospitalizaci�Qn), c) Diagn�Qstico y tratamiento de las complicaciones tromb�Qticas y d) Manejo de personas con indicaci�Qn previa a usar agentes anticoagulantes Conclusiones: las recomendaciones cl�Tnicas de este consenso orientan la toma de decisiones cl�Tnicas respecto a prevenci�Qn, diagn�Qstico y tratamiento de fen�Qmenos tromb�Qticos en pacientes con COVID-19, y representan un acuerdo que ayudar֙ a disminuir la dispersi�Qn en las pr֙cticas cl�Tnicas acorde con el desaf�To que nos impone la pandemia Introduction: recent studies have reported the occurrence of thrombotic phenomena or coagulopathy in patients with COVID-19 There are divergent positions regarding the prevention, diagnosis, and treatment of these phenomena, and current clinical practice is based solely on deductions by extension from retrospective studies, case series, observational studies, and international guidelines developed prior to the pandemic Objective: to generate a group of recommendations on the prevention, diagnosis and management of thrombotic complications associated with COVID-19 Methods: a rapid guidance was carried out applying the GRADE Evidence to Decision (EtD) frameworks and an iterative participation system, with statistical and qualitative analysis Results: 31 clinical recommendations were generated focused on: a) Coagulation tests in symptomatic adults with suspected infection or confirmed SARS CoV-2 infection;b) Thromboprophylaxis in adults diagnosed with COVID-19 (Risk scales, thromboprophylaxis for outpatient, in-hospital management, and duration of thromboprophylaxis after discharge from hospitalization), c) Diagnosis and treatment of thrombotic complications, and d) Management of people with previous indication of anticoagulant agents Conclusions: recommendations of this consensus guide clinical decision-making regarding the prevention, diagnosis, and treatment of thrombotic phenomena in patients with COVID-19, and represent an agreement that will help decrease the dispersion in clinical practices according to the challenge imposed by the pandemic
AU  - Acevedo-Peña, Juan
AU  - Yomayusa-Gonz֙lez, Nancy
AU  - Cantor-Cruz, Francy
AU  - Pinz�Qn-Fl�Qrez, Carlos
AU  - Barrero-Garz�Qn, Liliana
AU  - De-La-Hoz-Siegler, Ilich
AU  - Low-Padilla, Eduardo
AU  - Ram�Trez-Cer�Qn, Carlos
AU  - Combariza-Vallejo, Felipe
AU  - Arias-Barrera, Carlos
AU  - Moreno-Cortés, Javier
AU  - Rozo-Vanstrahlen, José Correa-Pérez Liliana
AU  - Rojas-Gambasica, José Gonz֙lez-Gonz֙lez Camilo
AU  - La-Rotta-Caballero, Eduardo
AU  - Ru�Tz-Talero, Paula
AU  - Contreras-P֙ez, Rubén Lineros-Montañez Alberto
AU  - Ordoñez-Cardales, Jorge
AU  - Escobar-Olaya, Mario
AU  - Izaguirre-Ávila, Raúl Campos-Guerra
AU  - Joao, Accini-Mendoza
AU  - José, Pizarro-G�Qmez Camilo
AU  - Patiño-Pérez, Adulkar�Tn Flores-Rodr�Tguez Janine
AU  - Valencia-Moreno, Albert
AU  - Londoño-Villegas, Alejandro
AU  - Saavedra-Rodr�Tguez, Alfredo
AU  - Madera-Rojas, Ana
AU  - Caballero-Arteagam, Andrés D�Taz-Campos Andrés Correa-Rivera
AU  - Felipe, Mantilla-Reinaud
AU  - Andrés, Becerra-Torres
AU  - Ángela, Peña-Castellanos Ángela Reina-Soler
AU  - Aura, Escobar-Suarez
AU  - Bibiana, Patiño-Escobar Bonell
AU  - Rodr�Tguez-Cortés, Camilo
AU  - Rebolledo-Maldonado, Carlos
AU  - Ocampo-Botero, Carlos
AU  - Rivera-Ordoñez, Carlos
AU  - Saavedra-Trujillo, Carlos
AU  - Figueroa-Restrepo, Catalina
AU  - Agudelo-L�Qpez, Claudia
AU  - Jaramillo-Villegas, Claudia
AU  - Villaquir֙n-Torres, Claudio
AU  - Rodr�Tguez-Ariza, Daniel
AU  - Rinc�Qn-Valenzuela, David
AU  - Lemus-Rojas, Melissa
AU  - Pinto-Pinz�Qn, Diego
AU  - Garz�Qn-D�Taz, Diego
AU  - Cubillos-Apolinar, Diego
AU  - Beltr֙n-Linares, Edgar
AU  - Kondo-Rodr�Tguez, Emilio
AU  - Yama-Mosquera, Erica
AU  - Polania-Fierro, Ernesto
AU  - Real-Urbina, Evalo
AU  - Rosas-Romero, Andrés Mendoza-Beltr֙n Fern֙n Guevara-Pulido
AU  - Fredy, Celia-M֙rquez Gina
AU  - Ramos-Ramos, Gloria
AU  - Prada-Mart�Tnez, Gonzalo
AU  - Le�Qn-Basantes, Guillermo
AU  - Liévano-S֙nchez, Guillermo
AU  - Ort�Tz-Ru�Tz, Guillermo
AU  - Barreto-Garc�Ta, Gustavo
AU  - Ibag�Qn-Nieto, Harold
AU  - Idrobo-Quintero, Henry
AU  - Mart�Tnez-Ram�Trez, Ingrid
AU  - Solarte-Rodr�Tguez, Ivan
AU  - Quintero-Barrios, Jorge
AU  - Arenas-Gamboa, Jaime
AU  - Pérez-Cely, Jairo
AU  - Castellanos-Parada, Jeffrey
AU  - Garz�Qn-Mart�Tnez, Fredy
AU  - Luna-R�Tos, Joaqu�Tn Lara-Ter֙n Joffre
AU  - Vargas-Rodr�Tguez, Johanna
AU  - Dueñas-Villamil, Rubén Boh�Qrquez-Reyes Vicente
AU  - Mart�Tnez-Acosta, Carlos
AU  - G�Qmez-Mesa, Esteban
AU  - Gait֙n-Rozo, Juli֙n Cortes-Colorado
AU  - Juli֙n, Coral-Casas
AU  - Juliana, Horlandy-G�Qmez Laura
AU  - Bautista-Toloza, Leonardo
AU  - Palacios, Leonardo Palacios
AU  - Fajardo-Latorre, Lina
AU  - Pino-Villarreal, Luis
AU  - Rojas-Puentes, Leonardo
AU  - Rodr�Tguez-S֙nchez, Patricia
AU  - Herrera-Méndez, Mauricio
AU  - Orozco-Levi, Mauricio
AU  - Sosa-Briceño, M�Qnica Moreno-Ru�Tz Nelson
AU  - S֙enz-Morales, Oscar
AU  - Amaya-Gonz֙lez, Pablo
AU  - Ram�Trez-Garc�Ta, Sergio
AU  - Nieto-Estrada, V�Tctor Carballo-Z֙rate Virgil
AU  - Abello-Polo, Virginia
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Consenso colombiano para la prevenci�Qn, el diagn�Qstico y el tratamiento de condiciones tromb�Qticas en adultos con COVID-19: aplicando el Marco de la Evidencia a la Decisi�Qn (EtD) GRADE
T2  - Revista Colombiana de Cardiolog�Ta
TI  - Consenso colombiano para la prevenci�Qn, el diagn�Qstico y el tratamiento de condiciones tromb�Qticas en adultos con COVID-19: aplicando el Marco de la Evidencia a la Decisi�Qn (EtD) GRADE
UR  - https://doi.org/10.1016/j.rccar.2020.08.003
ID  - 7793071
ER  - 

TY  - JOUR
AB  - The novel coronavirus COVID-19 is spreading all across the globe By June 29, 2020, the World Health Organization announced that the number of cases worldwide had reached 9?994?206 and resulted in more than 499?024 deaths The earliest case of COVID-19 in the Kingdom of Saudi Arabia (KSA) was registered on March 2 in 2020 Since then, the number of infections as per the outcome of the tests increased gradually on a daily basis The KSA has 182?493 cases, with 124?755 recoveries and 1551 deaths on June 29, 2020 There have been significant efforts to develop models that forecast the risks, parameters, and impacts of this epidemic These models can aid in controlling and preventing the outbreak of these infections In this regard, this article details the extent to which the infection cases, prevalence, and recovery rate of this pandemic are in the country and the predictions that can be made using the past and current data The well-known classical SIR model was applied to predict the highest number of cases that may be realized and the flattening of the curve afterward On the other hand, the ARIMA model was used to predict the prevalence cases Results of the SIR model indicate that the repatriation plan reduced the estimated reproduction number The results further affirm that the containment technique used by Saudi Arabia to curb the spread of the disease was efficient Moreover, using the results, close interaction between people, despite the current measures remains a great risk factor to the spread of the disease This may force the government to take even more stringent measures By validating the performance of the applied models, ARIMA proved to be a good forecasting method from current data The past data and the forecasted data, as per the ARIMA model provided high correlation, showing that there were minimum errors
AU  - Abuhasel, Khaled Ali
AU  - Khadr, Mosaad
AU  - Alquraish, Mohammed M.
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Analyzing and forecasting COVID-19 pandemic in the Kingdom of Saudi Arabia using ARIMA and SIR models
T2  - Computational Intelligence
TI  - Analyzing and forecasting COVID-19 pandemic in the Kingdom of Saudi Arabia using ARIMA and SIR models
UR  - https://doi.org/10.1111/coin.12407
ID  - 7792878
ER  - 

TY  - JOUR
AD  - Oral Pathology, Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
AN  - 33022845
AU  - Abrantes, T.
AU  - Bezerra, K. T.
AU  - da Silva, C. N.
AU  - Cardoso Costa, L.
AU  - Grillo Cabral, M.
AU  - Agostini, M.
AU  - de Andrade, B. A. B.
AU  - Corr�^a Abrahão, A.
AU  - José Romañach, M.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/odi.13669
DP  - NLM
ET  - 2020/10/07
J2  - Oral diseases
LA  - eng
N1  - 1601-0825
Abrantes, Thamiris
Orcid: 0000-0002-9382-912x
Bezerra, Kelly Tambasco
da Silva, Cristiane Nunes
Cardoso Costa, Lindaura
Grillo Cabral, M֙rcia
Agostini, Michelle
de Andrade, Bruno Augusto Benevenuto
Orcid: 0000-0002-3259-606x
Corr�^a Abrahão, Aline
Orcid: 0000-0002-3397-3234
José Romañach, M֙rio
Orcid: 0000-0002-7853-5916
Letter
Denmark
Oral Dis. 2020 Oct 6. doi: 10.1111/odi.13669.
PY  - 2020
SN  - 1354-523x
ST  - Oral Cancer diagnosis during the COVID-19 pandemic in an oral pathology laboratory in Rio de Janeiro, Brazil
T2  - Oral diseases
TI  - Oral Cancer diagnosis during the COVID-19 pandemic in an oral pathology laboratory in Rio de Janeiro, Brazil
ID  - 7790937
ER  - 

TY  - JOUR
AB  - INTRODUCTION: Electrocardiographic characteristics in COVID-19 related mortality have not yet been reported, particularly in racial/ethnic minorities. METHODS AND RESULTS: We reviewed demographics, laboratory and cardiac tests, medications, and cardiac rhythm proximate to death or initiation of comfort care for patients hospitalized with a positive SARS-CoV-2 RT-PCR in 3 New York City hospitals between March 1 and April 3, 2020 who died. We described clinical characteristics and compared factors contributing toward arrhythmic versus non-arrhythmic death. Of 1258 patients screened, 133 died and were enrolled. Of these, 55.6% (74/133) were male, 69.9% (93/133) were racial/ethnic minorities, and 88.0% (117/133) had cardiovascular disease (CVD). The last cardiac rhythm recorded was ventricular tachycardia or fibrillation in 5.3% (7/133), pulseless electrical activity in 7.5% (10/133), unspecified bradycardia in 0.8% (1/133), and asystole in 26.3% (35/133). Most 74.4% (99/133) died receiving comfort measures only. The most common abnormalities on admission electrocardiogram included abnormal QRS axis (25.8%), atrial fibrillation/flutter (14.3%), atrial ectopy (12.0%), and right bundle branch block (11.9%). During hospitalization, an additional 17.6% developed atrial ectopy, 14.7% ventricular ectopy, 10.1% atrial fibrillation/flutter, and 7.8% a right ventricular abnormality. Arrhythmic death was confirmed or suspected in 8.3% (11/133) associated with age, coronary artery disease, asthma, vasopressor use, longer admission corrected QT interval, and left bundle branch block (LBBB). CONCLUSIONS: Conduction, rhythm, and electrocardiographic abnormalities were common during COVID-19 related hospitalization. Arrhythmic death was associated with age, coronary artery disease, asthma, longer admission corrected QT interval, LBBB, ventricular ectopy, and usage of vasopressors. Most died receiving comfort measures. This article is protected by copyright. All rights reserved.
AD  - New York Presbyterian Hospital - Columbia University Irving Medical Center, Department of Medicine, Division of Cardiology, 177 Fort Washington Avenue, New York, NY, 10032.
AN  - 33022765
AU  - Abrams, M. P.
AU  - Wan, E. Y.
AU  - Waase, M. P.
AU  - Morrow, J. P.
AU  - Dizon, J. M.
AU  - Yarmohammadi, H.
AU  - Berman, J. P.
AU  - Rubin, G. A.
AU  - Kushnir, A.
AU  - Poterucha, T. J.
AU  - Elias, P. A.
AU  - Rubin, D. A.
AU  - Ehlert, F.
AU  - Biviano, A.
AU  - Uriel, N.
AU  - Garan, H.
AU  - Saluja, D.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/jce.14772
DP  - NLM
ET  - 2020/10/07
J2  - Journal of cardiovascular electrophysiology
KW  - Covid-19
arrhythmia
cardiac death
electrocardiography
epidemiology
sudden death
LA  - eng
N1  - 1540-8167
Abrams, Mark P
Orcid: 0000-0002-3219-2823
Wan, Elaine Y
Orcid: 0000-0002-5328-7282
Waase, Marc P
Morrow, John P
Dizon, Jose M
Yarmohammadi, Hirad
Orcid: 0000-0002-6072-5834
Berman, Jeremy P
Orcid: 0000-0001-6474-5800
Rubin, Geoffrey A
Kushnir, Alexander
Orcid: 0000-0003-1644-643x
Poterucha, Timothy J
Elias, Pierre A
Rubin, David A
Ehlert, Frederick
Biviano, Angelo
Uriel, Nir
Garan, Hasan
Saluja, Deepak
Journal Article
United States
J Cardiovasc Electrophysiol. 2020 Oct 6. doi: 10.1111/jce.14772.
PY  - 2020
SN  - 1045-3873
ST  - Clinical and Cardiac Characteristics of COVID-19 Mortalities in a Diverse New York City Cohort
T2  - Journal of cardiovascular electrophysiology
TI  - Clinical and Cardiac Characteristics of COVID-19 Mortalities in a Diverse New York City Cohort
ID  - 7790946
ER  - 

TY  - JOUR
AB  - The world is experiencing the worst global health crisis in recent decades since December/2019 due to a new pandemic coronavirus The COVID-19 disease, caused by SARS-CoV-2, has resulted in more than 30 million cases and 950 thousand deaths worldwide as of September 21, 2020 Determining the extent of the virus on public surfaces is critical for understanding the potential risk of infection in these areas In this study, we investigated the presence of SARS-CoV-2 RNA on public surfaces in a densely populated urban area in Brazil Forty-nine of 933 samples tested positive (5 25%) for SARS-CoV-2 RNA, including samples collected from distinct material surfaces, including metal and concrete, and distinct places, mainly around hospital care units and public squares Our data indicated the contamination of public surfaces by SARS-CoV-2, suggesting the circulation of infected patients and the risk of infection for the population Constant monitoring of the virus in urban areas is required as a strategy to fight the pandemic and prevent further infections
AU  - Abrahão, Jônatas Santos Sacchetto
AU  - L�Tvia, Rezende
AU  - Izabela Maur�Tcio, Rodrigues
AU  - Rodrigo Araújo Lima, Crispim
AU  - Ana Paula Correia, Moura
AU  - César, Mendonça Diogo Correia
AU  - Reis, Erik
AU  - Souza, Fernanda
AU  - Oliveira, Gabriela Fernanda Garcia
AU  - Domingos, Iago
AU  - de Miranda Boratto, Paulo Victor
AU  - Silva, Pedro Henrique Bastos
AU  - Queiroz, Victoria Fulg�^ncio Machado
AU  - Talita Bastos, Andrade
AU  - Luis Adan Flores, Lourenço Karine Lima
AU  - Silva, Tha�Ts Oliveira
AU  - Graziele Pereira, de Souza Alves
AU  - Viviane, Alves
AU  - Pedro Augusto, Kroon
AU  - Erna Geessien, de Souza Trindade
AU  - Giliane, Drumond
AU  - Betânia, Paiva
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Detection of SARS-CoV-2 RNA on public surfaces in a densely populated urban area of Brazil: a potential tool for monitoring the circulation of infected patients
T2  - Science of Total Environment
TI  - Detection of SARS-CoV-2 RNA on public surfaces in a densely populated urban area of Brazil: a potential tool for monitoring the circulation of infected patients
UR  - https://doi.org/10.1016/j.scitotenv.2020.142645
ID  - 7793053
ER  - 

TY  - JOUR
AB  - The hemagglutinin-esterase (HE) protein of betacoronavirus lineage A is a secondary receptor in the infection process and is involved in the emergence of new betacoronavirus genotypes with altered host specificity and tissue tropism. We previously reported a novel recombinant bovine coronavirus (BCoV) strain that was circulating in dairy cattle in China, but this virus was not successfully isolated, and the genetic characteristics of BCoV are still largely unknown. In this study, 20 diarrheic faecal samples were collected from a farm in Liaoning province that had an outbreak of calf diarrhea (≤�? months of age) in November 2018, and all of the samples tested positive for BCoV by RT-PCR. In addition, a BCoV strain with a recombinant HE (designated as SWUN/A1/2018) and another BCoV strain with a recombinant HE containing an insertion (designated as SWUN/A10/2018) were successfully isolated in cell culture (TCID50: 10(4.25)/mL and 10(4.73)/mL, respectively). Unexpectedly, we identified the emergence of a novel BCoV variant characterized by a 12-nt bovine gene insertion in the receptor-binding domain in a natural recombinant HE gene, suggesting a novel evolutionary pattern in BCoV.
AD  - College of Life Science and Technology, Southwest Minzu University, Chengdu, China.
Key Laboratory of Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, 610041, China.
College of Life Science and Technology, Southwest Minzu University, Chengdu, China. yhua900@163.com.
Key Laboratory of Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, 610041, China. yhua900@163.com.
College of Life Science and Technology, Southwest Minzu University, Chengdu, China. tangcheng101@163.com.
Key Laboratory of Qinghai Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Chengdu, 610041, China. tangcheng101@163.com.
AN  - 33025200
AU  - Abi, K. M.
AU  - Zhang, Q.
AU  - Zhang, B.
AU  - Zhou, L.
AU  - Yue, H.
AU  - Tang, C.
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1007/s00705-020-04840-y
DP  - NLM
ET  - 2020/10/08
J2  - Archives of virology
LA  - eng
N1  - 1432-8798
Abi, Keha-Mo
Zhang, Qi
Zhang, Bin
Zhou, Long
Yue, Hua
Tang, Cheng
Orcid: 0000-0003-2680-0519
2016YFD0500907/the 13th Five-Year Plan National Science and Technology Support Program/
3300220239/Fundamental Research Funds for the Central Universities, Southwest Minzu University/
Journal Article
Austria
Arch Virol. 2020 Oct 6. doi: 10.1007/s00705-020-04840-y.
PY  - 2020
SN  - 0304-8608
ST  - An emerging novel bovine coronavirus with a 4-amino-acid insertion in the receptor-binding domain of the hemagglutinin-esterase gene
T2  - Archives of virology
TI  - An emerging novel bovine coronavirus with a 4-amino-acid insertion in the receptor-binding domain of the hemagglutinin-esterase gene
ID  - 7790721
ER  - 

TY  - JOUR
AB  - Helminth infections are among the most common infectious diseases in underdeveloped countries Helminths suppress the host immune responses and consequently mitigate vaccine efficacy and increase severity of other infectious diseases Helminth co-infections might suppress the efficient immune response against SARS-CoV-2 at the early stage of the infection and may increase morbidity and mortality of COVID-19
AU  - Abdoli, Amir
C1  - 10/7/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge
T2  - ACS Pharmacology & Translational Science
TI  - Helminths and COVID-19 Co-Infections: A Neglected Critical Challenge
UR  - https://doi.org/10.1021/acsptsci.0c00141
ID  - 7793001
ER  - 

TY  - JOUR
AN  - 33021463
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0194599820964736
DP  - NLM
ET  - 2020/10/07
J2  - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
LA  - eng
N1  - 1097-6817
Journal Article
England
Otolaryngol Head Neck Surg. 2020 Oct 6:194599820964736. doi: 10.1177/0194599820964736.
PY  - 2020
SN  - 0194-5998
SP  - 194599820964736
ST  - Association Between COVID-19 and Kawasaki Disease: Vigilance Required From Otolaryngologists: Authors' Response
T2  - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
TI  - Association Between COVID-19 and Kawasaki Disease: Vigilance Required From Otolaryngologists: Authors' Response
ID  - 7791029
ER  - 

TY  - JOUR
AN  - 33024011
C1  - 10/7/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1136/vr.m3892
DP  - NLM
ET  - 2020/10/08
J2  - The Veterinary record
LA  - eng
N1  - 2042-7670
Journal Article
England
Vet Rec. 2020 Oct 6:vetrecm3892. doi: 10.1136/vr.m3892.
PY  - 2020
SN  - 0042-4900
ST  - Impending dog behaviour crisis following Covid-19 lockdown
T2  - Veterinary record
TI  - Impending dog behaviour crisis following Covid-19 lockdown
ID  - 7790853
ER  - 

TY  - JOUR
AB  - 'Covid toes' are being seen with increasing frequency in children and young adults during the COVID�?9 pandemic. Patients present with reddish or purple lesions (affected skin patches) located on the hands and/or feet, particularly fingers and toes. Detailed descriptions of biopsies of Covid toes have not been reported, and the virus called coronavirus SARS‐CoV�?, which causes the disease COVID�?9, has not been firmly established as the cause yet as most of the patients are negative for SARS‐CoV�? conventional tests (in which samples are taken from the nose and/or mouth). We examined skin biopsies from seven paediatric (child) patients presenting with Covid toes during the COVID�?9 pandemic in Madrid, Spain. The presence of coronavirus SARS‐CoV�? was investigated by electron microscopy and immunohistochemistry (staining that uses an antibody to recognise the virus). Our findings demonstrated the presence of vascular (blood vessel) damage and SARS‐CoV�? viral particles within the damaged endothelial cells (internal layer of blood vessels). Although the clinical features, meaning those seen outwardly, and histopathological features, meaning those seen in tissue samples, were similar to conventional chilblains, which are caused by cold temperatures, the presence of viral particles in the blood vessels and the evidence of vascular damage, support the idea that SARS‐CoV�? causes the lesions. Vascular damage caused by the virus could be a key mechanism to explain Covid toes and perhaps also other types of lesions seen in patients severely affected by COVID�?9. These findings can also help us to find a treatment focused on avoiding the vascular damage caused by the virus. Linked Article:Colmenero et al. Br J Dermatol 2020; 183:729�?37. Linked Article:Colmenero et al. Br J Dermatol 2020; 183:729�?37. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Dermatology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146218174
C1  - 10/7/2020
DB  - a9h
DO  - 10.1111/bjd.19442
DP  - EBSCOhost
IS  - 4
M3  - Article
N1  - Source Info: Oct2020, Vol. 183 Issue 4, pe131; Number of Pages: 1p; Document Type: Article; Full Text Word Count: 285
PY  - 2020
SN  - 00070963
SP  - e131-e131
ST  - SARS‐CoV�? causes Covid Toes
T2  - British Journal of Dermatology
TI  - SARS‐CoV�? causes Covid Toes
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146218174&site=ehost-live
VL  - 183
ID  - 7789737
ER  - 

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