TY  - JOUR
AB  - BACKGROUND: The COVID-19 pandemic essentially imposes psychological effects on people. As the pandemic progresses, people experience psychological trauma gradually, which can change over time. The present study aimed to assess the prevalence of depression, anxiety, and stress among Bangladeshi people four months after the COVID-19 outbreak. METHODS: An online cross-sectional survey was conducted among Bangladeshi citizens aged �?8 years from June 1 to June 10, 2020. The participants completed an online questionnaire examining socio-demographic variables and COVID-19 related factors, along with the Depression Anxiety and Stress Scale 21. A total of 1146 respondents have been included in the study. Data were analyzed using the Statistical Package for Social Sciences, IBM Statistics version 22.0. RESULTS: The prevalence of moderate to the extremely severe levels of depression, anxiety, and stress was 47.2%, 46.0%, and 32.5%, respectively, with no significant gender differences. The prevalence of anxiety and stress was significantly higher in participants aged 30 than in participants aged 18-30 years. Daily follow up COVID-19 related news, having COVID-19 symptoms so far, having contact (direct or indirect) with COVID-19 infected person, and fear of infection were significantly associated with depression, anxiety, and stress. CONCLUSIONS: Sizable proportions of participants had depression, anxiety and stress four months after the COVID-19 outbreak in Bangladesh. The findings of this study underscores the need for strategies aimed at reducing these psychological sufferings in Bangladeshi people in the context of COVID-19.
AD  - Department of Sociology, University of Barishal, Barishal, Bangladesh.
Department of Public Health & Informatics, Jahangirnagar University, Savar, Dhaka, Bangladesh.
Centre for Entrepreneurship Development (CED), BRAC University (BRACU), Mohakhali, Dhaka, Bangladesh.
Chandigarh University, Panjab, India.
Dhaka Community Medical College,Mogbazar, Dhaka, Bangladesh.
Sheikh Sayera khatun Medical College, Gopalganj, Bangladesh.
Syed Nazrul Islam Medical College, Kishoreganj, Bangladesh.
AN  - 33015396
AU  - Zubayer, A. A.
AU  - Rahman, M. E.
AU  - Islam, M. B.
AU  - Babu, S. Z. D.
AU  - Rahman, Q. M.
AU  - Bhuiyan, Mram
AU  - Khan, M. K. A.
AU  - Chowdhury, M. A. U.
AU  - Hossain, L.
AU  - Habib, R. B.
C1  - 10/6/2020
C2  - PMC7521899
DA  - Sep
DB  - PubMed
DO  - 10.1016/j.heliyon.2020.e05057
DP  - NLM
ET  - 2020/10/06
IS  - 9
J2  - Heliyon
KW  - Anxiety
Bangladeshi people
Covid-19
Depression
Psychological states
Psychology
Stress
LA  - eng
N1  - 2405-8440
Zubayer, Abdullah Al
Rahman, Md Estiar
Islam, Md Bulbul
Babu, Sritha Zith Dey
Rahman, Quazi Maksudur
Bhuiyan, Md Rifat Al Mazid
Khan, Md Kamrul Ahsan
Chowdhury, Md Ashraf Uddin
Hossain, Liakat
Habib, Rahat Bin
Journal Article
Heliyon. 2020 Sep;6(9):e05057. doi: 10.1016/j.heliyon.2020.e05057. Epub 2020 Sep 28.
PY  - 2020
SN  - 2405-8440 (Print)
2405-8440
SP  - e05057
ST  - Psychological states of Bangladeshi people four months after the COVID-19 pandemic: An online survey
T2  - Heliyon
TI  - Psychological states of Bangladeshi people four months after the COVID-19 pandemic: An online survey
VL  - 6
ID  - 7785309
ER  - 

TY  - JOUR
AB  - COVID-19 pandemic has provoked a huge change in daily functioning in millions of people worldwide. The epidemiological measures in prevention of possible infection have increased the possible risks on the mental and physical health. We have conducted a survey in order to investigate the needs and challenges of families with children with chronic respiratory diseases. In this order, we have created a questionnaire with general information about the family, general information about the child with chronic respiratory disease, overall physical and mental health before and during the pandemic, needs and mental health condition of the parents/caregivers. This survey showed that this group of families of children with respiratory disorders have suffered financially in significant way and has changed the way they perform professional and educational patterns due to the pandemic. Most of the children were stable in their physical health, but their mental health has deteriorated. This is probably due to the regular contact with the medical staff, but not with the mental health professionals. This group of children has a significant reduction in their physical activity and increase the hours in front of TV screens. The further effect on the physical and mental health is to be investigated.
AD  - University Children's Hospital, Skopje, RN Macedonia.
Institute for Respiratory Diseases in Children, Skopje, RN Macedonia.
AN  - 33011701
AU  - Zorcec, T.
AU  - Jakovska, T.
AU  - Micevska, V.
AU  - Boskovska, K.
AU  - Cholakovska, V. C.
C1  - 10/6/2020
DA  - Sep 1
DB  - PubMed
DO  - 10.2478/prilozi-2020-0038
DP  - NLM
ET  - 2020/10/05
IS  - 2
J2  - Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)
KW  - COVID-19 pandemic
children
chronic respiratory disease
LA  - eng
N1  - 1857-8985
Zorcec, Tatjana
Jakovska, Tatjana
Micevska, Vesna
Boskovska, Katerina
Cholakovska, Valentina Cvejoska
Journal Article
North Macedonia
Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2020 Sep 1;41(2):95-101. doi: 10.2478/prilozi-2020-0038.
PY  - 2020
SN  - 1857-9345
SP  - 95-101
ST  - Pandemic with COVID-19 and Families with Children with Chronic Respiratory Diseases
T2  - Prilozi (Makedonska akademija na naukite i umetnostite Oddelenie za medicinski nauki)
TI  - Pandemic with COVID-19 and Families with Children with Chronic Respiratory Diseases
VL  - 41
ID  - 7785663
ER  - 

TY  - JOUR
AB  - I compare the extent of food hardships in the United States among adults and seniors before and during the Covid-19 Pandemic Food insufficiency increased three-fold compared to 2019, and more than doubled relative to the Great Recession Food insufficiency among seniors increased 75 percent during the Covid period, but more than doubled when including reduced intake of food varieties Receipt of charitable foods among disadvantaged adults spiked 50 percent in the Covid period, but the initial response among seniors was a sharp reduction, before rising These patterns are consistent with strong social distancing measures enacted in response to the Pandemic
AU  - Ziliak, James P.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Food Hardship during the Covid-19 Pandemic and Great Recession
T2  - Applied Economic Perspectives and Policy
TI  - Food Hardship during the Covid-19 Pandemic and Great Recession
UR  - https://doi.org/10.1002/aepp.13099
ID  - 7788126
ER  - 

TY  - JOUR
AB  - Background: COVID-19 (coronavirus disease 2019) has become a global public health emergency since patients were first detected in Wuhan, China, in December 2019. Currently, there are no satisfying antiviral medications and vaccines available. Case Presentation: We reported the treatment process and clinical outcome of a 48-year-old man critically ill COVID-19 patient who received transfusion of allogenic human umbilical cord mesenchymal stem cells (UC-MSCs). Conclusions: We proposed that UC-MSC transfusion might be a new option for critically ill COVID-19. Although only one case we were shown, more similar clinical cases are inquired for further evidence providing the potential effectiveness of UC-MSC treatment. © 2020 Zhu et al.
AD  - Stem Cell Lab, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China
Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
Department of Respiratory and Critical Care Medicine, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
Molecular Laboratory, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
Gonadal Biology Research Group, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China
The Ministry of Science and Education, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
Department of Pharmacy, Puren Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei 430081, China
School of Life Sciences, Shanghai University, Shanghai, 200444, China
AU  - Zhu, Y.
AU  - Zhu, R.
AU  - Liu, K.
AU  - Li, X.
AU  - Chen, D.
AU  - Bai, D.
AU  - Luo, J.
AU  - Liu, Y.
AU  - Zhang, Y.
AU  - Li, L.
AU  - Hu, J.
AU  - Xu, D.
AU  - Liu, Y.
AU  - Zhao, R. C.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.2147/IDR.S272645
J2  - Infect. Drug Resist.
KW  - Case report
Cell transplantation
COVID-19
Critically ill
UC-MSCs
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Liu, Y.; Stem Cell Lab, Puren Hospital Affiliated to Wuhan University of Science and Technology, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical CollegeChina; email: liuyan@wust.edu.cn
Funding details: National Key Research and Development Program of China, NKRDPC, 2016YF A0101003, 2016YF A0101000, 2020YFC0844000, 2018YF A0109800
Funding details: B18007, 2017-I2M -3-007
Funding text 1: This work was supported by the National Key Research and Development Program of China (2016YF A0101000, 2016YF A0101003, 2018YF A0109800, 2020YFC0844000), CAMS Innovation Fund for Medical Sciences (2017-I2M -3-007) and the 1 1 1 Project (B18007). The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication.
References: Munster, VJ, Koopmans, M, van Doremalen, N, A novel corona-virus emerging in China �?key questions for impact assessment (2020) N Engl J Med, 382, pp. 692-694; Huang, C, Wang, Y, Li, X, Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China (2020) Lancet, 395, pp. 497-506; Lu, R, Zhao, X, Li, J, Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding (2020) Lancet, 395, pp. 565-574; Xu, X, Chen, P, Wang, J, Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission (2020) Sci China Life Sci, 63, pp. 457-460; Zhang, Q, Lu, S, Li, T, ACE2 inhibits breast cancer angiogenesis via suppressing the VEGFa/VEGFR2/ERK pathway (2019) CR, 38, p. 173; Wilson, JG, Zhuo, H, Mesenchymal stem (stromal) cells for treatment of ARDS: a Phase 1 clinical trial (2015) Lancet Respiratory Med, 3, pp. 24-32. , K D L; Connick, P, Kolappan, M, Crawley, C, Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclero-sis: an open-label phase 2a proof-of-concept study (2012) Lancet Neurol, 11, pp. 150-156; Hashmi, S, Ahmed, M, Murad, MH, Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host dis-ease: systematic review and meta-analysis (2016) Lancet Haematol, 3, p. e4552; Bernardo, ME, Fibbe, WE., Mesenchymal stromal cells: sensors and switchers of inflammation (2013) Cell Stem Cell, 13, pp. 392-402; Darwish, I, Mubareka, S, Liles, WC., Immunomodulatory therapy for severe influenza (2011) Expert Rev Anti Infect Ther, 9, pp. 807-822; Muraca, M, Pessina, A, Pozzobon, M, Mesenchymal stromal cells and their secreted extracellular vesicles as therapeutic tools for COVID-19 pneumonia? Published online ahead of print, 2020 Jul 3 (2020) J Control Release, 325, pp. 135-140; Bari, E, Ferrarotti, I, Saracino, L, Perteghella, S, Torre, ML, Corsico, AG., Mesenchymal stromal cell secretome for severe COVID-19 infections: premises for the therapeutic use (2020) Cells, 9 (4), p. 924; Bari, E, Ferrarotti, I, Torre, ML, Corsico, AG, Perteghella, S., Mesenchymal stem/stromal cell secretome for lung regeneration: the long way through “pharmaceuticalization�?for the best formula-tion (2019) J Control Release, 309, pp. 11-24; Esposito, M, Lucariello, A, Costanzo, C, Differentiation of human umbilical cord-derived mesenchymal stem cells, WJ-MSCs, into chondrogenic cells in the presence of pulsed electromagnetic fields (2013) Vivo (Brooklyn), 27, pp. 495-500; Shu, Y, Yang, C, Ji, X, Reversibly immortalized human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are responsive to BMP9-induced osteogenic and adipogenic differentiation (2018) J Cell Biochem, 119, pp. 8872-8886
PY  - 2020
SN  - 11786973 (ISSN)
SP  - 3295-3300
ST  - Human umbilical cord mesenchymal stem cells for adjuvant treatment of a critically ill COVID-19 patient: A case report
T2  - Infection and Drug Resistance
TI  - Human umbilical cord mesenchymal stem cells for adjuvant treatment of a critically ill COVID-19 patient: A case report
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091720068&doi=10.2147%2fIDR.S272645&partnerID=40&md5=cab435074227ebb0d9269fbe495a629b
VL  - 13
ID  - 7783258
ER  - 

TY  - JOUR
AB  - BACKGROUND Coronavirus disease 19 (COVID-19) is a global pandemic and has had a profound impact on our routine surgical activities. Acute appendicitis is the most common abdominal emergency worldwide. Therefore, it is highly essential to assess the influence the pandemic has on acute appendicitis. AIM To assess the efficacy of the management of acute appendicitis during the COVID-19 pandemic. METHODS We retrospectively analyzed 90 patients who presented with acute appendicitis during the outbreak of COVID-19 in Jiaxing, China. Clinical data regarding appendectomies patients were also collected for the corresponding time frame from 2019. Preoperative management, intraoperative protective measures, and postoperative management were conducted. RESULTS After screening, six patients were identified as unqualified due to fever and were then referred to the COVID-19 expert group. The results of the nucleic acid test were negative. Of the 76 patients enrolled in the simple group, nine patients received medication therapy, and all others underwent surgery. From this same group, 66 patients were diagnosed with suppurative appendicitis, and one patient was diagnosed with perforated appendicitis after surgery. There were 14 patients in the complex group, for which the postoperative diagnosis indicated perforated appendicitis. The proportion of men with perforated appendicitis was higher than that in 2019 (P  0.05). The chief complaint duration for perforated appendicitis patients in 2020 was longer than that in 2019 (P  0.05). The routine blood test showed that white blood cell counts and neutrophil ratios were higher in perforated appendicitis patients in 2020 than in 2019 (P  0.05). The ratio of open appendectomies to the amount of mean blood loss during surgery was greater in 2020 than in 2019 (P  0.05). Online consultation after discharge was selected in 59 cases (65.6%). No perioperative infection with COVID-19 or long-term postoperative complications were found. CONCLUSION The management of acute appendicitis from Jiaxing effectively reduced the influence of the pandemic and minimized the risk of nosocomial infection. Copyright © The Author(s) 2020.
AD  - (Zhou) Department of Gastrointestinal Surgery, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province 31400, China (Cen) Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province 310006, China
L.-S. Cen, Department of Ophthalmology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 Youdian Road, Hangzhou, Zhejiang Province 310006, China. E-mail: cenlusa2@sina.com
AN  - 632998307
AU  - Zhou, Y.
AU  - Cen, L. S.
C1  - 10/6/2020
DA  - 01 Oct
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i19.4349
DP  - Ovid Technologies
IS  - 19
KW  - Acute appendicitis
covid-19
Pandemic
Perforated appendicitis
Perioperative management
Postoperative management
adult
appendectomy
appendix perforation
article
China
comparative effectiveness
complication
consultation
controlled study
coronavirus disease 2019
fever
hospital infection
human
human cell
leukocyte count
major clinical study
male
neutrophil
operative blood loss
postoperative care
postoperative complication
retrospective study
surgery
nucleic acid
LA  - English
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 4349-4359
ST  - Managing acute appendicitis during the COVID-19 pandemic in Jiaxing, China
T2  - World Journal of Clinical Cases
TI  - Managing acute appendicitis during the COVID-19 pandemic in Jiaxing, China
UR  - https://f6publishing.blob.core.windows.net/9aa93a3b-c827-4216-a87e-bd93d73f6798/WJCC-8-4349.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998307
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i19.4349&issn=2307-8960&isbn=&volume=8&issue=19&spage=4349&pages=4349-4359&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Managing+acute+appendicitis+during+the+COVID-19+pandemic+in+Jiaxing%2C+China&aulast=Zhou&pid=%3Cauthor%3EZhou+Y.%2CCen+L.-S.%3C%2Fauthor%3E&%3CAN%3E632998307%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 8
ID  - 7782822
ER  - 

TY  - JOUR
AB  - As a novel enteropathogenic coronavirus, porcine deltacoronavirus (PDCoV) warrants further investigation. In this study, a Chinese PDCoV strain, designated CHN-HN-1601, was isolated from the feces of a diarrheic piglet. After plaque purification, the genome was determined which shared 97.5%-99.5% nucleotide identities with 71 representative PDCoV strains available in the GenBank. The pathogenic properties of CHN-HN-1601 were evaluated using 5-day-old piglets. All inoculated piglets developed severe diarrhea from 2 days post-infection (dpi) onwards. To our surprise, two periods of diarrhea starting from 2 to 7 dpi and from 13 to 19 dpi were observed in affected piglets during the experiment. Fecal viral shedding of the inoculated piglets was detected by real-time RT-PCR, with viral shedding peaked at 4 and 16 dpi, respectively. At necropsy at 5 dpi, the main gross lesions included transparent, thin-walled and gas-distended intestines containing yellow watery contents. Further histopathological examinations, including hematoxylin and eosin staining, immunohistochemistry, RNAscope in situ hybridization revealed that the virus infection caused severe villous atrophy of the small intestines, with PDCoV antigen and RNA mainly distributed in the cytoplasm of the villous epithelial cells of jejunum and ileum in piglets. The dynamic production of PDCoV-specific IgG and neutralizing antibodies in serum of the affected piglets was also assessed using a whole virus-based ELISA and an immunofluorescence assay-based neutralization test, respectively. Furthermore, a full-length cDNA infectious clone of CHN-HN-1601 was constructed using a bacterial artificial chromosome system. The rescued virus exhibited in vitro growth and pathogenic properties similar to the parental virus. Taken together, our study not only enriches the information of PDCoV, but also provides a useful reverse genetics platform for further pathogenesis exploration of the virus.
AD  - Key Laboratory of Animal Epidemiology of Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
AN  - 33012120
AU  - Zhou, X.
AU  - Zhou, L.
AU  - Zhang, P.
AU  - Ge, X.
AU  - Guo, X.
AU  - Han, J.
AU  - Zhang, Y.
AU  - Yang, H.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/tbed.13862
DP  - NLM
ET  - 2020/10/05
J2  - Transboundary and emerging diseases
KW  - cDNA infectious clone
genome
pathogenicity
piglets
porcine deltacoronavirus (PDCoV)
LA  - eng
N1  - 1865-1682
Zhou, Xinrong
Zhou, Lei
Zhang, Pingping
Ge, Xinna
Guo, Xin
Han, Jun
Zhang, Yongning
Orcid: 0000-0002-0134-2761
Yang, Hanchun
Journal Article
Germany
Transbound Emerg Dis. 2020 Oct 4. doi: 10.1111/tbed.13862.
PY  - 2020
SN  - 1865-1674
ST  - A strain of porcine deltacoronavirus: genomic characterization, pathogenicity and its full-length cDNA infectious clone
T2  - Transboundary and emerging diseases
TI  - A strain of porcine deltacoronavirus: genomic characterization, pathogenicity and its full-length cDNA infectious clone
ID  - 7785618
ER  - 

TY  - JOUR
AD  - State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China. nanshan@vip.163.com.
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
AN  - 33017033
AU  - Zhong, N. S.
AU  - Yang, Z. F.
AU  - Jiang, M.
AU  - Liang, J. Y.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1007/s11655-020-3437-4
DP  - NLM
ET  - 2020/10/06
J2  - Chinese journal of integrative medicine
LA  - eng
N1  - Zhong, Nan-Shan
Yang, Zi-Feng
Jiang, Mei
Liang, Jing-Yi
Journal Article
China
Chin J Integr Med. 2020 Oct 5. doi: 10.1007/s11655-020-3437-4.
PY  - 2020
SN  - 1672-0415 (Print)
1672-0415
ST  - A Potential Chinese Medicine Granule Suppressing ARDS of COVID-19: Keguan-1
T2  - Chinese journal of integrative medicine
TI  - A Potential Chinese Medicine Granule Suppressing ARDS of COVID-19: Keguan-1
ID  - 7785168
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 pandemic, the fourth pandemic of the decade, has underscored gaps in global pandemic preparedness and the need for generalizable tests to avert overwhelming healthcare systems worldwide, irrespective of a virus. We integrated 4,780 blood transcriptome profiles from patients infected with one of 16 viruses across 34 independent cohorts from 18 countries, and 71 scRNA-seq profiles of 264,224 immune cells across three independent cohorts. We found a myeloid cell-dominated conserved host response associated with severity. It showed increased hematopoiesis, myelopoiesis, and myeloid-derived suppressor cells with increased severity. We identified four gene modules that delineate distinct trajectories associated with mild and severe outcomes, and show the interferon response was decoupled from protective host response during severe viral infection. These modules distinguished non-severe from severe viral infection with clinically useful accuracy. Together, our findings provide insights into immune response dynamics during viral infection, and identify factors that may influence patient outcomes.Competing Interest StatementEJGB has received honoraria from Abbott CH, Angelini Italy, bioMerieux Inc, InflaRx GmbH, MSD Greece, and XBiotech Inc.; independent educational grants from AbbVie, Abbott, Astellas Pharma Europe, AxisShield, bioMerieux Inc, InflaRx GmbH, ThermoFisher Brahms GmbH, and XBiotech Inc; and funding from the FrameWork 7 program HemoSpec (granted to the National and Kapodistrian University of Athens), the Horizon2020 Marie-Curie Project European Sepsis Academy (granted to the National and Kapodistrian University of Athens), and the Horizon 2020 European Grant ImmunoSep (granted to the Hellenic Institute for the Study of Sepsis). PK is a shareholder and a consultant to Inflammatix, Inc. YH and YH are employees of, and stockholders in, Inflammatix, Inc.Funding StatementPK is funded in part by the Bill and Melinda Gates Foundation (OPP1113682); the National Institute of Allergy and Infectious Diseases (NIAID) grants 1U19AI109662, U19AI057229, and 5R01AI125197; Department of Defense contracts W81XWH-18-1-0253 and W81XWH1910235; and the Ralph &amp;amp; Marian Falk Medical Research Trust. AMR and YL are funded by National Science Foundation Graduate Research Fellowship. AMR is also funded by Stanford Graduate Fellowship. YL is also funded by the Knight-Hennessy Scholars Program. JT is funded by National Science Scholarship (PhD) from the Agency of Science, Technology, and Research (A*STAR), Singapore.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No IRB approval is required for this paper because aAll data used in this paper are already publicly available. No data were generated for the analyses in this paper.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data are publicly available from public repositories of gene expression data including the Gene Expression Omnibus, EBI ArrayExpress, Sequence Read Archive, and others. The identifiers for each study are listed in Supplementary Table 1 and all figures.
AU  - Zheng, Hong
AU  - Rao, Aditya M.
AU  - Dermadi, Denis
AU  - Toh, Jiaying
AU  - Jones, Lara Murphy
AU  - Donato, Michele
AU  - Liu, Yiran
AU  - Su, Yapeng
AU  - Karagiannis, Minas
AU  - Marantos, Theodoros
AU  - Hasin-Brumshtein, Yehudit
AU  - He, Yudong D.
AU  - Giamarellos-Bourboulis, Evangelos J.
AU  - Heath, Jim
AU  - Khatri, Purvesh
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205880
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205880
ST  - Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity irrespective of virus (preprint)
T2  - medRxiv
TI  - Multi-cohort analysis of host immune response identifies conserved protective and detrimental modules associated with severity irrespective of virus (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205880.abstract
ID  - 7788890
ER  - 

TY  - JOUR
AB  - In December 2019, an outbreak of unexplained pneumonia was reported in Wuhan, China. The World Health Organization officially named this disease as novel coronavirus disease 2019 (COVID-19). Liver injury was observed in patients with COVID-19, and its severity varied depending on disease severity, geographical area, and patient age. Systemic inflammatory response, immune damage, ischemia-reperfusion injury, viral direct damage, drug induce, mechanical ventilation, and underlying diseases may contribute to liver injury. Although, in most cases, mild liver dysfunction is observed, which is usually temporary and does not require special treatment, the importance of monitoring liver injury should be emphasized for doctors. The risk of COVID-19 infection of liver transplantation recipients caused more and more concerns. In this article, we aimed to review the available literature on liver injury in COVID-19 to highlight the importance of monitoring and treating liver injury in COVID-19. Copyright © The Author(s) 2020.
AD  - (Zhao, Fan, Wu) Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province 110004, China
Y. Fan, Department of General Surgery, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China. E-mail: coolingpine78@163.com
AN  - 632998284
AU  - Zhao, J. N.
AU  - Fan, Y.
AU  - Wu, S. D.
C1  - 10/6/2020
DA  - 01 Oct
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i19.4303
DP  - Ovid Technologies
IS  - 19
KW  - covid-19
Hepatoprotective drugs
Liver injury
Novel coronavirus
Pandemic
SARS-CoV-2
adult
artificial ventilation
coronavirus disease 2019
hepatitis
human
liver transplantation
mild hepatic impairment
reperfusion injury
short survey
surgery
liver protective agent
LA  - English
M3  - Short Survey
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 4303-4310
ST  - Liver injury in COVID-19: A minireview
T2  - World Journal of Clinical Cases
TI  - Liver injury in COVID-19: A minireview
UR  - https://www.wjgnet.com/2307-8960/about.htm
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998284
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i19.4303&issn=2307-8960&isbn=&volume=8&issue=19&spage=4303&pages=4303-4310&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Liver+injury+in+COVID-19%3A+A+minireview&aulast=Zhao&pid=%3Cauthor%3EZhao+J.-N.%2CFan+Y.%2CWu+S.-D.%3C%2Fauthor%3E&%3CAN%3E632998284%3C%2FAN%3E&%3CDT%3EShort+Survey%3C%2FDT%3E
VL  - 8
ID  - 7782823
ER  - 

TY  - JOUR
AD  - Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China.
University of Chinese Academy of Sciences, 100049, Beijing, China.
Hunan Normal University, School of Medicine, 410081, Changsha, China.
State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, 430071, Wuhan, Hubei, China.
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. yehq@wh.iov.cn.
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, China. zhangbo@wh.iov.cn.
AN  - 33011739
AU  - Zhang, Z. R.
AU  - Zhang, Y. N.
AU  - Li, X. D.
AU  - Zhang, H. Q.
AU  - Xiao, S. Q.
AU  - Deng, F.
AU  - Yuan, Z. M.
AU  - Ye, H. Q.
AU  - Zhang, B.
C1  - 10/6/2020
C2  - PMC7532339
DA  - Oct 3
DB  - PubMed
DO  - 10.1038/s41392-020-00343-z
DP  - NLM
ET  - 2020/10/05
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
Zhang, Zhe-Rui
Zhang, Ya-Nan
Li, Xiao-Dan
Zhang, Hong-Qing
Xiao, Shu-Qi
Deng, Fei
Yuan, Zhi-Ming
Ye, Han-Qing
Orcid: 0000-0001-7770-4071
Zhang, Bo
Orcid: 0000-0002-8895-3679
Letter
Signal Transduct Target Ther. 2020 Oct 3;5(1):218. doi: 10.1038/s41392-020-00343-z.
PY  - 2020
SN  - 2095-9907 (Print)
2059-3635
SP  - 218
ST  - A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2
T2  - Signal transduction and targeted therapy
TI  - A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2
VL  - 5
ID  - 7785657
ER  - 

TY  - JOUR
AB  - Purpose: There is increasing evidence indicating that considerable fractions of cases of SARS-CoV-2 infection are asymptomatic. We traced three asymptomatic clusters to investigate the infectivity of subclinical cases of coronavirus disease 2019 (COVID-19). Patients and Methods: Three medical staff who were asymptomatic were diagnosed with coronavirus disease 2019 by serological tests. Their close contacts were systematically evaluated based on COVID-19-related symptoms, nucleic acid tests, serological tests, and chest computed tomography (CT) as needed to determine if they were infected by SARS-CoV-2. Result(s): None of the staff's close contacts, including 10 family members, were infected by the indexes, even though no protective measures were taken. Conclusion(s): The infectivity of asymptomatic subclinical infection patients of coronavirus disease 2019 seems to be low. Copyright © 2020 Zhang et al.
AD  - (Zhang) Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China (Chen, Wei, Zhou, Cao, Wang) Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
Y. Cao, Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. E-mail: caoyangemma@163.com G. Wang, Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China. E-mail: gxwtjxy@126.com
AN  - 2005146768
AU  - Zhang, X.
AU  - Chen, L.
AU  - Wei, J.
AU  - Zhou, J.
AU  - Cao, Y.
AU  - Wang, G.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.2147/IDR.S261304
DP  - Ovid Technologies
KW  - Asymptomatic
Close contact
covid-19
Infectivity
SARS-CoV-2
adult
article
asymptomatic infection
computer assisted tomography
coronavirus disease 2019
human
medical staff
serology
thorax
virus transmission
nucleic acid
LA  - English
PY  - 2020
SN  - 1178-6973 (electronic)
1178-6973
SP  - 3267-3271
ST  - Asymptomatic subclinical cases of coronavirus disease 2019 without viral transmission in three independent families
T2  - Infection and Drug Resistance
TI  - Asymptomatic subclinical cases of coronavirus disease 2019 without viral transmission in three independent families
UR  - https://www.dovepress.com/getfile.php?fileID=61760
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005146768
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.2147%2FIDR.S261304&issn=1178-6973&isbn=&volume=13&issue=&spage=3267&pages=3267-3271&date=2020&title=Infection+and+Drug+Resistance&atitle=Asymptomatic+subclinical+cases+of+coronavirus+disease+2019+without+viral+transmission+in+three+independent+families&aulast=Zhang&pid=%3Cauthor%3EZhang+X.%2CChen+L.%2CWei+J.%2CZhou+J.%2CCao+Y.%2CWang+G.%3C%2Fauthor%3E&%3CAN%3E2005146768%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 13
ID  - 7782992
ER  - 

TY  - JOUR
AD  - Department of Urology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, China.
AN  - 33016165
AU  - Zhang, P.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/13685538.2020.1825667
DP  - NLM
ET  - 2020/10/06
J2  - The aging male : the official journal of the International Society for the Study of the Aging Male
LA  - eng
N1  - 1473-0790
Zhang, Peng
Journal Article
England
Aging Male. 2020 Oct 5:1. doi: 10.1080/13685538.2020.1825667.
PY  - 2020
SN  - 1368-5538
SP  - 1
ST  - Comment on the review entitled "Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies"
T2  - aging male : official journal of International Society for Study of Aging Male
TI  - Comment on the review entitled "Risk factors for mortality in patients with Coronavirus disease 2019 (COVID-19) infection: a systematic review and meta-analysis of observational studies"
ID  - 7785216
ER  - 

TY  - JOUR
AB  - This paper introduces a multigroup COVID-19 model with immunity, in which the total population of each group is partitioned into five compartments, that is, susceptible, exposed, infective, infective in treatment and recovered compartment. If the basic reproduction number is less than or equal to one, and the infection graph is strongly connected, then the disease-free equilibrium is globally asymptotically stable and the disease dies out. However, the COVID-19 is already in a pandemic state, and the basic reproduction number is large than one. Hence, in order to make the COVID-19 die out in some groups in an area, we design some appropriate control strategies which reduce the number of exposed people and increase the number of people treated. These two methods have been proved to be the most effective methods at present. An effective algorithm is proposed to identify the groups that need to be controlled. Finally, we use the actual limited data of Hubei, Guangdong and Zhejiang provinces in China to illustrate the effectiveness of the obtained results. © 2020, Springer Nature B.V.
AD  - The School of Automation, Chongqing University of Posts and Telecommunications, Chongqing, 400065, China
Chongqing University Cancer Hospital, Chongqing, 400030, China
AU  - Zhai, S.
AU  - Gao, H.
AU  - Luo, G.
AU  - Tao, J.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s11071-020-05961-4
J2  - Nonlinear Dyn
KW  - Basic reproduction number
Multigroup model
Stability
Epidemiology
Control strategies
Disease-free equilibrium
Effective algorithms
Globally asymptotically stable
Number of peoples
Strongly connected
Zhejiang Province
Cell proliferation
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
CODEN: NODYE
Correspondence Address: Zhai, S.; The School of Automation, Chongqing University of Posts and Telecommunications, Chongqing University Cancer HospitalChina; email: zhaisd@cqupt.edu.cn
Funding details: Natural Science Foundation of Chongqing, cstc2019jcyj-msxmX0109
Funding details: Chongqing Municipal Education Commission, CQMEC, KJQN202000608
Funding text 1: The authors would like to thank the Editor, the Associate Editor and anonymous reviewers for their valuable comments and suggestions that have helped to improve this paper considerably. This work was supported in part by the Natural Science Foundation of Chongqing of China under Grant cstc2019jcyj-msxmX0109, the Scientific and Technological Research Program of Chongqing Municipal Education Commission under Grant KJQN202000608.
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PY  - 2020
SN  - 0924090X (ISSN)
ST  - Control of a multigroup COVID-19 model with immunity: treatment and test elimination
T2  - Nonlinear Dynamics
TI  - Control of a multigroup COVID-19 model with immunity: treatment and test elimination
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091733364&doi=10.1007%2fs11071-020-05961-4&partnerID=40&md5=5254fbaf223f8a826581d38c4fc71c2a
ID  - 7783299
ER  - 

TY  - JOUR
AU  - Zeeshan Hameed, B.
AU  - Patil, Vathsala
AU  - Shetty, Dasharathraj
AU  - Naik, Nithesh
AU  - Nagaraj, Nikhil
AU  - Sharma, Disha
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Use of artificial intelligence-based computer vision system to practice social distancing in hospitals to prevent transmission of COVID-19
T2  - Indian Journal of Community Medicine
TI  - Use of artificial intelligence-based computer vision system to practice social distancing in hospitals to prevent transmission of COVID-19
UR  - https://doi.org/10.4103/ijcm.IJCM_366_20
ID  - 7788393
ER  - 

TY  - JOUR
AD  - Department of Surgery, Dentistry, Paediatrics and Gynecology, Woman &amp; Child Hospital, Verona, Italy - nicola.zampieri@aovr.veneto.it.
Division, of Pediatric Surgery, University of Verona, Verona, Italy - nicola.zampieri@aovr.veneto.it.
Unit of Pediatrics and Neonatology, Maternal-Infant Department, Fracastoro Hospital, San Bonifacio, Verona, Italy.
AN  - 33016682
AU  - Zampieri, N.
AU  - Cinquetti, M.
AU  - Murri, V.
AU  - Camoglio, F. S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.23736/s0026-4946.20.05901-0
DP  - NLM
ET  - 2020/10/06
J2  - Minerva pediatrica
LA  - eng
N1  - 1827-1715
Zampieri, Nicola
Cinquetti, Mauro
Murri, Virginia
Camoglio, Francesco S
Journal Article
Italy
Minerva Pediatr. 2020 Oct 5. doi: 10.23736/S0026-4946.20.05901-0.
PY  - 2020
SN  - 0026-4946
ST  - Incidence of appendicitis during SARS-CoV-2 pandemic quarantine: report of a single area experience
T2  - Minerva pediatrica
TI  - Incidence of appendicitis during SARS-CoV-2 pandemic quarantine: report of a single area experience
ID  - 7785185
ER  - 

TY  - JOUR
AB  - BACKGROUND: Although diffuse alveolar damage and respiratory failure are the key features of coronavirus disease 2019 (COVID-19), the involvement of other organs such as the kidney has also been reported. The reports of the incidence of acute kidney injury (AKI) in COVID-19 patients vary widely. In this study, we report our unique experience with AKI in COVID-19 patients in a low socioeconomic and predominantly ethnic minority group and provide its incidence, risk factors, and prognosis to expand the current understanding of this complication. METHODS: In this single-center, retrospective cohort study, we analyzed the data of 469 COVID-19 patients admitted to the Brookdale University Hospital in Brooklyn, NY, from March 18 through April 23, 2020. Information regarding demographics, comorbidities, medications, clinical and laboratory data, and outcomes was collected from the electronic medical records. Both univariate and multivariate analyses were performed to determine the association of AKI with in-hospital mortality. RESULTS: The median age was 66 years (interquartile range [IQR] 25-75; range 19-101 years), and 268 (57.14%) patients were male. Estimated glomerular filtration rate (eGFR) as determined by the Modification of Diet in Renal Disease Study Equation was low (60 mL/min/1.73 m2) in 207 (44.1%) patients. During hospitalization, 128 (27.3%) patients developed AKI, and the incidence was significantly higher in those patients presenting with a low eGFR (N = 81, 39.1%; p  0.001). Male sex, hypertension, the use of angiotensin-converting enzyme inhibitors and non-steroidal anti-inflammatories, hemodynamic instability, mechanical ventilation, acute respiratory distress syndrome, and admission elevated ferritin, creatinine kinase, brain natriuretic peptide, and troponin 1 were identified as the risk factors for in-hospital AKI. Ninety-seven (28.45%) patients died in the non-AKI group versus 91 (71.1%) in the AKI group (p  0.001). The Cox proportional hazard model after adjusting for age, gender, comorbidities, hemodynamic status, and PF ratio (arterial oxygen partial pressure [PaO2]/fractional inspired oxygen [FiO2]) determined that on admission, an elevated blood urea nitrogen (hazard ratio [HR]: 1.75; 95% confidence interval [CI] 1.23-2.48), a low eGFR (HR 1.43; CI 1.1-2.03), AKI stage 1 (HR 1.14; CI 0.64-2.03), AKI stage 2 (HR 1.86; CI 1.03-3.56), and AKI stage 3 (HR 2.1; CI 1.3-2.81) were independent risk factors for in-hospital mortality. Renal replacement therapy (RRT) did not improve survival in stage III AKI. CONCLUSION: AKI in our hospitalized COVID-19 patients was common and carried a high mortality, especially in patients with AKI stage 3. RRT did not improve survival. Policy changes and planning for this high incidence of AKI in COVID-19 patients and its associated high mortality are necessary at the local and national levels.
AD  - Division of Nephrology, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA.
Division of Hematology/Oncology, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA.
Department of Internal Medicine, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA.
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Division of Nephrology, Brookdale University Hospital and Medical Center, Brooklyn, New York, USA, pbedi@bhmcny.org.
AN  - 33011717
AU  - Zahid, U.
AU  - Ramachandran, P.
AU  - Spitalewitz, S.
AU  - Alasadi, L.
AU  - Chakraborti, A.
AU  - Azhar, M.
AU  - Mikhalina, G.
AU  - Sherazi, A.
AU  - Narh, J. T.
AU  - Khattar, P.
AU  - Bedi, P.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1159/000511160
DP  - NLM
ET  - 2020/10/05
J2  - American journal of nephrology
KW  - Acute kidney injury
Acute respiratory distress syndrome
Coronavirus disease 19
In-hospital mortality
LA  - eng
N1  - 1421-9670
Zahid, Umar
Ramachandran, Preethi
Spitalewitz, Samuel
Alasadi, Lutfi
Chakraborti, Abhishek
Azhar, Muhammad
Mikhalina, Galina
Sherazi, Andleeb
Narh, Joshua Tetteh
Khattar, Pallavi
Bedi, Puneet
Journal Article
Switzerland
Am J Nephrol. 2020 Oct 2:1-11. doi: 10.1159/000511160.
PY  - 2020
SN  - 0250-8095
SP  - 1-11
ST  - Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications
T2  - American journal of nephrology
TI  - Acute Kidney Injury in COVID-19 Patients: An Inner City Hospital Experience and Policy Implications
ID  - 7785661
ER  - 

TY  - JOUR
AB  - Nanomaterials have wide-ranging biomedical applications in prevention, treatment and control of diseases. Nanoparticle based vaccines have proven prodigious prophylaxis of various infectious and non-infectious diseases of human and animal concern. Nano-vaccines outnumber the conventional vaccines by virtue of plasticity in physio-chemical properties and ease of administration. The efficacy of nano-based vaccines may be attributed to the improved antigen stability, minimum immuno-toxicity, sustained release, enhanced immunogenicity and the flexibility of physical features of nanoparticles. Based on these, the nano-based vaccines have potential to evoke both cellular and humoral immune responses. Targeted and highly specific immunological pathways required for solid and long lasting immunity may be achieved with specially engineered nano-vaccines. This review presents an insight into the prevention of infectious diseases (of bacterial, viral and parasitic origin) and non-infectious diseases (cancer, auto-immune diseases) using nano-vaccinology. Additionally, key challenges to the effective utilization of nano-vaccines from bench to clinical settings have been highlighted as research domains for future.
AD  - Department of Parasitology, University of Agriculture, Faisalabad, Faisalabad 38040, Pakistan.
Federal University of Rio de Janeiro, Cidade Universit֙ria, Rio de Janeiro - RJ, 21941-901, Brazil.
Wuhan University, 8 East Lake South Road, Wuchang 430072, Hubei Province,China.
Department of Pathology, University of Agriculture, Faisalabad, Faisalabad 38040, Pakistan.
AN  - 33013180
AU  - Zaheer, T.
AU  - Pal, K.
AU  - Zaheer, I.
C1  - 10/6/2020
C2  - PMC7521878
DA  - Sep 28
DB  - PubMed
DO  - 10.1016/j.procbio.2020.09.028
DP  - NLM
ET  - 2020/10/06
J2  - Process biochemistry (Barking, London, England)
KW  - CAPN, Calcium-phosphate nanoparticles
CNT, Carbon nanotube
COVID-19, Corona virus disease-2019
Chi-Alg, Chitosan alginate
HIV, Human immune deficiency virus
HPV, Human papilloma virus
ISCOMS, Immune stimulating complexes
IgA, Immunoglobulin A
Immunity
MERS, Middle-East respiratory syndrome
MRSA, Methcillin resistant Staphylococcus aureus
NMVs, Nano multilamellar lipid vesicles
Nanoparticles
PLGA, Poly(lactic-co-glycolic acid)
PSNP, Polystyrene nanoparticles
Pathogens
Prevention
SAPN, Self-Assembling Protein Nanoparticle
SARS-CoV-1, Severe acute respiratory syndrome Coronavirus-1
VLP, Virus like particles
Vaccine
LA  - eng
N1  - 1873-3298
Zaheer, Tean
Pal, Kaushik
Zaheer, Iqra
Journal Article
Review
Process Biochem. 2020 Sep 28. doi: 10.1016/j.procbio.2020.09.028.
PY  - 2020
SN  - 1359-5113 (Print)
1359-5113
ST  - Topical Review On Nano-vaccinology: Biochemical Promises and Key Challenges
T2  - Process biochemistry (Barking, London, England)
TI  - Topical Review On Nano-vaccinology: Biochemical Promises and Key Challenges
ID  - 7785485
ER  - 

TY  - JOUR
AU  - Zacharowski, K.
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - de
PY  - 2020
ST  - FX06-COVID: Verbesserung der Oxygenierung durch FX06 in Intensivpatienten mit schweren Verläufen von COVID-19
T2  - Anaesthesist
TI  - FX06-COVID: Verbesserung der Oxygenierung durch FX06 in Intensivpatienten mit schweren Verläufen von COVID-19
TT  - [FX06-COVID: Improvement of arterial oxygenation in intensive care patients with a severe course of COVID-19].
UR  - https://dx.doi.org/10.1007/s00101-020-00862-y
ID  - 7788501
ER  - 

TY  - JOUR
AB  - Prior to the COVID-19 pandemic, African-American mothers were three times as likely to die from pregnancy-related causes compared to white mothers. The impact of the pandemic among African-Americans could further worsen the racial disparities in maternal mortality (MM) and severe maternal morbidity (SMM). This study aimed to create a theoretical framework delineating the contributors to an expected rise in maternal mortality (MM) and severe maternal morbidity (SMM) among African-Americans in the era of the COVID-19 pandemic due to preliminary studies suggesting heightened vulnerability of African-Americans to the virus as well as its adverse health effects. Rapid searches were conducted in PubMed and Google to identify published articles on the health determinants of MM and SMM that have been or likely to be disproportionately affected by the pandemic in African-Americans. We identified socioeconomic and health trends determinants that may contribute to future adverse maternal health outcomes. There is a need to intensify advocacy, implement culturally acceptable programs, and formulate policies to address social determinants of health.
AD  - College of Nursing and Public Health, Adelphi University, Garden City, NY, USA.
Center of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, Houston, TX, USA.
Department of Family and Community Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA.
Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USA.
AN  - 33014625
AU  - Yusuf, K. K.
AU  - Dongarwar, D.
AU  - Ibrahimi, S.
AU  - Ikedionwu, C.
AU  - Maiyegun, S. O.
AU  - Salihu, H. M.
C1  - 10/6/2020
C2  - PMC7520882
DB  - PubMed
DO  - 10.21106/ijma.405
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - International journal of MCH and AIDS
KW  - African-Americans
Covid-19
Maternal mortality
Severe maternal morbidity
LA  - eng
N1  - 2161-864x
Yusuf, Korede K
Dongarwar, Deepa
Ibrahimi, Sahra
Ikedionwu, Chioma
Maiyegun, Sitratullah O
Salihu, Hamisu M
Journal Article
Int J MCH AIDS. 2020;9(3):386-389. doi: 10.21106/ijma.405. Epub 2020 Sep 16.
PY  - 2020
SN  - 2161-8674 (Print)
2161-864x
SP  - 386-389
ST  - Expected Surge in Maternal Mortality and Severe Morbidity among African-Americans in the Era of COVID-19 Pandemic
T2  - International journal of MCH and AIDS
TI  - Expected Surge in Maternal Mortality and Severe Morbidity among African-Americans in the Era of COVID-19 Pandemic
VL  - 9
ID  - 7785386
ER  - 

TY  - JOUR
AB  - OBJECTIVE: COVID 19 is a global health problem that can result in serious complications. The aim of this study was to investigate the prevalence and clinical importance of vitamin D deficiency in children with COVID-19. MATERIAL AND METHODS: This study includes 40 patients who were diagnosed to have COVID- 19 and hospitalized with the real-time reverse transcription polymerase chain reaction (RT-PCR) method, 45 healthy matched control subjects with normal vitamin D levels. The age of admission, clinical and laboratory data, and 25-hydroxycholecalciferol (25-OHD) levels were recorded. Those with vitamin D levels which are below 20 ng/ml were determined as Group 1 and those with �?0 ng/ml as Group 2. RESULTS: Patients with COVID- 19 had significantly lower vitamin D levels 13.14 μg/L (4.19-69.28) than did the controls 34.81(3.8-77.42) μg/L (p  0.001). Patients with COVID- 19 also had significantly lower serum phosphorus (4.09�u0.73 vs. 5.06�u0.93vs (U/L) (p0.001) values compared with the controls. The symptom of fever was significantly higher in COVID- 19 patients who had deficient and insufficient vitamin D levels than in patients who had sufficient vitamin D levels (p=0.038). There was a negative correlation found between fever symptom and vitamin D level (r=-0.358, p = 0.023). CONCLUSION: This is the first to evaluate vitamin D levels and its relationship with clinical findings in pediatric patients with COVID-19. Our results suggest that vitamin D values may be associated with the occurrence and management of the COVID-19 disease by modulating the immunological mechanism to the virus in the pediatric population. This article is protected by copyright. All rights reserved.
AD  - Dicle University School of Medicine, Department of Pediatric, Diyarbakir, Turkey.
Dicle University School of Medicine, Department of Pediatric Pulmonology, Diyarbakir, Turkey.
AN  - 33017102
AU  - Y�\lmaz, K.
AU  - Şen, V.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/ppul.25106
DP  - NLM
ET  - 2020/10/06
J2  - Pediatric pulmonology
KW  - Epidemiology
LA  - eng
N1  - 1099-0496
Y�\lmaz, Kamil
Orcid: 0000-0001-5137-0501
Şen, Velat
Journal Article
United States
Pediatr Pulmonol. 2020 Oct 5. doi: 10.1002/ppul.25106.
PY  - 2020
SN  - 1099-0496
ST  - Is Vitamin D Deficiency a Risk Factor for Covid 19 in Children?
T2  - Pediatric pulmonology
TI  - Is Vitamin D Deficiency a Risk Factor for Covid 19 in Children?
ID  - 7785162
ER  - 

TY  - JOUR
AB  - This study reports longitudinal viral RNA loads from nasopharynx/throat in patients with mild and severe/critical COVID-19. We also investigated whether the duration of symptoms correlated with the duration of viral RNA shedding. A total of 56 patients were included. The highest viral loads occurred early after onset of symptoms. Neither the viral RNA loads in the upper respiratory tract, nor the time to viral RNA clearance differed between patients with mild or severe/critical disease. There was a moderate correlation between number of days with symptoms and number of days with viral RNA shedding in patients with mild COVID-19.
AD  - Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Infectious Diseases, Sahlgrenska University Hospital, Gothenburg, Sweden.
Department of Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden.
AN  - 33020822
AU  - Yilmaz, A.
AU  - Marklund, E.
AU  - Andersson, M.
AU  - Nilsson, S.
AU  - Andersson, L. M.
AU  - Lindh, M.
AU  - Gisslén, M.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/infdis/jiaa632
DP  - NLM
ET  - 2020/10/07
J2  - The Journal of infectious diseases
KW  - Covid-19
SARS-CoV-2
nasopharynx
viral shedding
LA  - eng
N1  - 1537-6613
Yilmaz, Aylin
Marklund, Emelie
Andersson, Maria
Nilsson, Staffan
Andersson, Lars-Magnus
Lindh, Magnus
Gisslén, Magnus
Journal Article
United States
J Infect Dis. 2020 Oct 6:jiaa632. doi: 10.1093/infdis/jiaa632.
PY  - 2020
SN  - 0022-1899
ST  - Upper respiratory tract levels of SARS-CoV-2 RNA and duration of viral RNA shedding do not differ between patients with mild and severe/critical COVID-19
T2  - Journal of infectious diseases
TI  - Upper respiratory tract levels of SARS-CoV-2 RNA and duration of viral RNA shedding do not differ between patients with mild and severe/critical COVID-19
ID  - 7784975
ER  - 

TY  - JOUR
AB  - COVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline structure of the SARS-CoV-2 main protease Mpro (also called 3CLpro) bound to a synthetic inhibitor, which represents a major druggable target. The druggability of Mpro could be used for discovering drugs to treat COVID-19. A multilevel computational study was carried out to evaluate the potential antiviral properties of the components of the medicinal herb Uncaria tomentosa (Cat's claw), focusing on the inhibition of Mpro. The in silico approach starts with protein-ligand docking of 26 Cat's claw key components, followed by ligand pathway calculations, molecular dynamics simulations, and MM-GBSA calculation of the free energy of binding for the best docked candidates. The structural bioinformatics approaches led to identification of three bioactive compounds of Uncaria tomentosa (speciophylline, cadambine, and proanthocyanidin B2) with potential therapeutic effects by strong interaction with 3CLpro. Additionally, in silico drug-likeness indices for these components were calculated and showed good predicted therapeutic profiles of these phytochemicals. Our findings suggest the potential effectiveness of Cat's claw as complementary and/or alternative medicine for COVID-19 treatment. [ABSTRACT FROM AUTHOR]
Copyright of Evidence-based Complementary & Alternative Medicine (eCAM) is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146190777
AU  - Yepes-Pérez, Andres F.
AU  - Herrera-Calderon, Oscar
AU  - S֙nchez-Aparicio, José-Emilio
AU  - Tiessler-Sala, Laura
AU  - Maréchal, Jean-Didier
AU  - Cardona-G, Wilson
C1  - 10/6/2020
DB  - a9h
DO  - 10.1155/2020/4932572
DP  - EBSCOhost
M3  - Article
N1  - Yepes-Pérez, Andres F. 1 Herrera-Calderon, Oscar 2 S֙nchez-Aparicio, José-Emilio 3 Tiessler-Sala, Laura 3 Maréchal, Jean-Didier 3 Cardona-G, Wilson 1; Affiliation: 1: Chemistry of Colombian Plants, Institute of Chemistry, Faculty of Exact and Natural Sciences, University of Antioquia-UdeA, Calle 70 No. 52-21, A.A 1226, Medellin, Colombia 2: Academic Department of Pharmacology, Bromatology and Toxicology, Faculty of Pharmacy and Biochemistry, Universidad Nacional Mayor de San Marcos, Jr Puno 1002, Lima 15001, Peru 3: Insilichem, Departament de Qu�Tmica, Universitat Autònoma de Barcelona, Edifici C.n., 08193 Cerdanyola del Vallés, Barcelona, Spain; Source Info: 10/1/2020, p1; Number of Pages: 14p; Document Type: Article; Full Text Word Count: 9133
PY  - 2020
SN  - 1741427X
SP  - 1-14
ST  - Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat's Claw) against the Main Protease 3CLpro of SARS-CoV-2 by Molecular Modeling
T2  - Evidence-based Complementary & Alternative Medicine (eCAM)
TI  - Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat's Claw) against the Main Protease 3CLpro of SARS-CoV-2 by Molecular Modeling
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146190777&site=ehost-live
ID  - 7783640
ER  - 

TY  - JOUR
AB  - The possibility that RNA transcripts from clinical samples contain plenty of virus RNAs has not been pursued actively so far. We here developed a new tool for analyzing virus-transcribed mRNAs, not virus copy numbers, in the data of bulk and single-cell RNA-sequencing of human cells. Our pipeline, named VIRTUS (VIRal Transcript Usage Sensor), was able to detect 762 viruses including herpesviruses, retroviruses, and even SARS-CoV-2 (COVID-19), and quantify their transcripts in the sequence data. This tool thus enabled simultaneously detecting infected cells, the composition of multiple viruses within the cell, and the endogenous host gene expression profile of the cell. This bioinformatics method would be instrumental in addressing the possible effects of covertly infecting viruses on certain diseases and developing new treatments to target such viruses. AVAILABILITY: VIRTUS is implemented using Common Workflow Language and Docker under a CC-NC license. VIRTUS is freely available at https://github.com/yyoshiaki/VIRTUS. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
AD  - Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.
Department of Immunology, Nara Medical University, Kashihara, Nara, Japan.
AN  - 33017003
AU  - Yasumizu, Y.
AU  - Hara, A.
AU  - Sakaguchi, S.
AU  - Ohkura, N.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1093/bioinformatics/btaa859
DP  - NLM
ET  - 2020/10/06
J2  - Bioinformatics (Oxford, England)
LA  - eng
N1  - 1367-4811
Yasumizu, Yoshiaki
Hara, Atsushi
Sakaguchi, Shimon
Ohkura, Naganari
Journal Article
England
Bioinformatics. 2020 Oct 5:btaa859. doi: 10.1093/bioinformatics/btaa859.
PY  - 2020
SN  - 1367-4803
ST  - VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
T2  - Bioinformatics (Oxford, England)
TI  - VIRTUS: a pipeline for comprehensive virus analysis from conventional RNA-seq data
ID  - 7785169
ER  - 

TY  - JOUR
AB  - With the rapid global spread of the COVID-19 pandemic, researchers have contributed several important advances. The WHO and countries with severe outbreaks have developed diagnosis and treatment guidelines. Here, we analyze the current transformation and application of scientific research to global epidemic prevention and control. We described and analyzed current COVID-19 research from the perspectives of international cooperation, interdisciplinary cooperation, and research hotspots using a bibliometric clustering algorithm. Using the diagnosis and treatment guidelines of the WHO and the United States and China as examples, we evaluate the transformation of scientific results from basic research to applications. Scientific research results that have not yet been incorporated into these guidelines are summarized to encourage updates and improvements by applying scientific research to prevention and control. COVID-19 has fostered interdisciplinary cooperative research, and the current results are mainly focused on the origin, epidemiological characteristics, clinical research, and diagnosis and treatment methods for the virus. Due to the ongoing publication of new research, diagnosis and treatment guidelines are constantly improving. However, some research gaps still exist, and some results have not yet been incorporated into the guidelines. The current research is still in the preliminary exploratory stage, and some problems, such as weak international cooperation, unbalanced interdisciplinary cooperation, and the lack of coordination between research and applications, exist. Therefore, countries around the world must improve the International Public Health Emergency Management System and prepare for major public health emergencies in the future. Copyright © 2020, Springer Nature Switzerland AG.
AD  - (Yang, Zhang, Wang, Han, Wang, Wu, Xue) Department of Epidemiology and Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China (Yang, Zhang, Wang, Zhang, Han, Wang, Wu, Xue) Institute for Medical Dataology, Shandong University, Jinan, Shandong 250002, China
F. Xue, Institute for Medical Dataology, Shandong University, Jinan, Shandong 250002, China. E-mail: xuefzh@sdu.edu.cn
AN  - 2006827959
AU  - Yang, F.
AU  - Zhang, S.
AU  - Wang, Q.
AU  - Zhang, Q.
AU  - Han, J.
AU  - Wang, L.
AU  - Wu, X.
AU  - Xue, F.
C1  - 10/6/2020
DA  - 01 Dec
DB  - Embase
DO  - http://dx.doi.org/10.1007/s13755-020-00120-w
DP  - Ovid Technologies
IS  - 30
KW  - Bibliometrics
covid-19
Diagnosis and treatment guidelines
Global epidemic
article
basic research
China
clinical research
clustering algorithm
controlled study
coordination disorder
coronavirus disease 2019
epidemic
exploratory research
human
international cooperation
nonhuman
practice guideline
prevention
public health
United States
virus
LA  - English
PY  - 2020
SN  - 2047-2501 (electronic)
2047-2501
ST  - Analysis of the global situation of COVID-19 research based on bibliometrics
T2  - Health Information Science and Systems
TI  - Analysis of the global situation of COVID-19 research based on bibliometrics
UR  - http://www.springer.com/journal/13755/about
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006827959
VL  - 8 (1) (no pagination)
ID  - 7782958
ER  - 

TY  - JOUR
AB  - Since the first case was reported at the end of 2019, COVID-19 has spread throughout the world and has become a pandemic. The high transmission rate of the virus has made it a threat to public health globally. Viral infections may trigger acute coronary syndromes, arrhythmias, and exacerbation of heart failure, due to a combination of effects including significant systemic inflammatory responses and localized vascular inflammation at the arterial plaque level. Indonesian clinical practice guideline stated that (hydroxy)chloroquine alone or in combination with azithromycin may be used to treat for COVID-19. However, chloroquine, hydroxychloroquine, and azithromycin all prolong the QT interval, raising concerns about the risk of arrhythmic death from individual or concurrent use of these medications. To date, there is still no vaccine or specific antiviral treatment for COVID-19. Therefore, prevention of infection in people with cardiovascular risk and mitigation of the adverse effects of treatment is necessary.
AD  - Department of Internal Medicine, Faculty of Medicine University of Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. muhyam511@gmail.com.
AN  - 33020340
AU  - Yamin, M.
AU  - Demili, A. U.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Qt
arrhythmia
azithromycin
covid-19
hydroxychlorine
LA  - eng
N1  - Yamin, Muhammad
Demili, Amanda Ulfah
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):290-296.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 290-296
ST  - Prevention of Ventricular Arrhythmia and Sudden Cardiac Death in COVID-19 Patients
T2  - Acta medica Indonesiana
TI  - Prevention of Ventricular Arrhythmia and Sudden Cardiac Death in COVID-19 Patients
VL  - 52
ID  - 7785030
ER  - 

TY  - JOUR
AD  - Department of Plastic Surgery & Burns, Rabin Medical Center, Petah Tikva, Israel; affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv.
Plastic Surgery & Burns Unit, Schneider Children's Medical Center of Israel, Petah Tikva Israel, affiliated with the Sackler Faculty of Medicine.
Orthopedic Surgery Department, Meir Medical Center, Kfar Saba, Israel, affiliated with the Sackler Faculty of Medicine.
AN  - 33011781
AU  - Yaacobi, D. S.
AU  - Ad-El, D.
AU  - Kalish, E.
AU  - Yaacobi, E.
AU  - Olshinka, A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1093/jbcr/iraa171
DP  - NLM
ET  - 2020/10/05
J2  - Journal of burn care & research : official publication of the American Burn Association
KW  - covid-19 management strategies
pediatric burns management
LA  - eng
N1  - 1559-0488
Yaacobi, Dafna Shilo
Ad-El, Dean
Kalish, Eyal
Yaacobi, Eyal
Olshinka, Asaf
Journal Article
England
J Burn Care Res. 2020 Oct 5:iraa171. doi: 10.1093/jbcr/iraa171.
PY  - 2020
SN  - 1559-047x
ST  - Management strategies for pediatric burns during the COVID-19 pandemic
T2  - Journal of burn care & research : official publication of American Burn Association
TI  - Management strategies for pediatric burns during the COVID-19 pandemic
ID  - 7785654
ER  - 

TY  - JOUR
AD  - King's College London , London, UK.
Concordia University of Edmonton , Edmonton, Canada.
AN  - 33016163
AU  - Xyrichis, A.
AU  - Williams, U.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/13561820.2020.1829037
DP  - NLM
ET  - 2020/10/06
J2  - Journal of interprofessional care
KW  - Covid-19
Health Systems
Interprofessional Care
Interprofessional Education
LA  - eng
N1  - 1469-9567
Xyrichis, Andreas
Williams, Uzma
Journal Article
England
J Interprof Care. 2020 Oct 5:1-3. doi: 10.1080/13561820.2020.1829037.
PY  - 2020
SN  - 1356-1820
SP  - 1-3
ST  - Strengthening health systems response to COVID-19: interprofessional science rising to the challenge
T2  - Journal of interprofessional care
TI  - Strengthening health systems response to COVID-19: interprofessional science rising to the challenge
ID  - 7785217
ER  - 

TY  - JOUR
AB  - Employing the tools of multifractal detrended cross-correlation analysis (MF-DCCA) and Diebold–Yilmaz spillover index (D.Y. spillover index), we examine the effect that the foreign investors have on the cross-correlations between the two-segment stock markets, that are the accessible and the inaccessible stock markets, and the other ten respective stock markets. The shares cross-listed by the same corporates on both the A-share and H-share stock markets of China serve as the best sample to compile the two stock indices, which stands for the inaccessible stock market (AHA) and the accessible stock market (AHH), respectively. Empirical results show that the cross-correlations between the two-segment stock markets and the other ten pairs are multifractal, the multifractal strength of cross-correlations is stronger in AHH than AHA, and the intensified growth of the multifractal cross-correlations in AHA can be seen as the increasing of the openness in the inaccessible market. The empirical result of D.Y. spillover index is consistent with the multifractal analysis above, and another interesting finding is that among the selected markets, the three markets with the strongest spillover effects with AHA and AHH are Taiwan, South Korea, and Singapore, respectively, and the weakest one is Australia during the sample scenarios.
AD  - School of Management, Harbin Institute of Technology, Harbin, Heilongjiang, China ; School of Management, Harbin Institute of Technology, Harbin, Heilongjiang, China
AN  - 2448259422
AU  - Xu, Nan
AU  - Li, Songsong
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/5836142
DP  - ProQuest Central
KW  - Mathematics
Research
Stock exchanges
Accessibility
Efficient markets
Fractal analysis
Macroeconomics
Investments
Hypotheses
Securities markets
Bond markets
Empirical analysis
International finance
Segments
Deregulation
New stock market listings
COVID-19
Correlation analysis
Hong Kong
United States--US
China
LA  - English
N1  - Copyright - Copyright © 2020 Nan Xu and Songsong Li. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
SubjectsTermNotLitGenreText - United States--US; China; Hong Kong
PY  - 2020
SN  - 10762787
ST  - Segment Stock Market, Foreign Investors, and Cross-Correlation: Evidence from MF-DCCA and Spillover Index
T2  - Complexity
TI  - Segment Stock Market, Foreign Investors, and Cross-Correlation: Evidence from MF-DCCA and Spillover Index
UR  - https://www.proquest.com/docview/2448259422?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahightechjournals&atitle=Segment+Stock+Market%2C+Foreign+Investors%2C+and+Cross-Correlation%3A+Evidence+from+MF-DCCA+and+Spillover+Index&title=Complexity&issn=10762787&date=2020-01-01&volume=2020&issue=&spage=&au=Xu%2C+Nan%3BLi%2C+Songsong&isbn=&jtitle=Complexity&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F5836142
VL  - 2020
ID  - 7784943
ER  - 

TY  - JOUR
AB  - This article is an account of a telepsychological intervention addressed to a 9 years old child and his family during the Italian lockdown called for Prime Minister Decree (DPCM) on 11th March 2020, due to SARS-CoV2 pandemic. We explain the pediatric psychological cornerstone constructs and how we made them operational in a long-distance therapeutic relationship, by means of counselling strategies and specific homeworks. © 2020, Associazione Culturale Pediatri. All rights reserved.
AD  - Treviso, Italy
AU  - Xodo, A.
AU  - Buffon, L.
AU  - Conz, M.
AU  - Vianello, S.
C1  - 10/6/2020
DB  - Scopus
IS  - 5
J2  - Quad. ACP
LA  - Italian
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Xodo, A.Italy; email: alberta.xodo@gmail.com
References: Guidelines for the practice of telepsychology (2013) Am Psychol, 68 (9), pp. 791-800. , Joint Task Force for the Development of Telepsychology Guidelines for Psychologists. Dec; Salvini, A, Dondoni, M., (2011) Psicologia clinica dell �?interazione e psicoterapia, , Giunti; Atkinson, R., (2002) L�?intervista narrativa, , Raffaelo Cortina; Sullivan, JR., Skype: An Appropriate Meth-od of Data Collection for Qualitative Inter-views? (2012) The Hilltop Review, 6 (1), p. 10. , Dec; Capurso, M., (2017) Facilitare la comprensione della malattia nel bambino, , Franco Angeli; La Greca, AM, Mackey, ER., Adherence to Pediatric Treatment Regimens (2009) Handobook of Pediatric Psychology, , Roberts MC, Steele RG (a cura di). The Guilford Press; Https://www.who.int/chp/knowledge/pub-lications/adherence:report/en/; Bonichini, S, Tremolada, M., (2019) Psicologia pe-diatrica, , Carocci; Lazarus, RS, Folkman, S., (1994) Stress, appreisal and coping, , Springer Publishing Company; Rotter, JB., Generalized expectancies for internal versus external control of reinforce-ment (1966) Psychol Monogr, 80 (1), pp. 1-28; Cornoldi, C, De Beni, R., (2013) Imparare a studi-are 2. Strategie, stili cognitivi, metacognizione e atteggiamenti nello studio, , Erickson; Ivy, JW, Meindl, JN, Overley, E, Robson, KM., Token Economy: A Systematic Review of Procedural Descriptions (2017) Behav Modif, 41 (5), pp. 708-737. , Sep
PY  - 2020
SN  - 20391374 (ISSN)
SP  - 215-218
ST  - L’educazione terapeutica per migliorare l’aderenza alle disposizioni precauzionali: Un progetto di telepsicologia rivolto a un bambino di 9 anni e alla sua famiglia durante la quarantena disposta dal dpcm 11 marzo 2020
T2  - Quaderni ACP
TI  - L’educazione terapeutica per migliorare l’aderenza alle disposizioni precauzionali: Un progetto di telepsicologia rivolto a un bambino di 9 anni e alla sua famiglia durante la quarantena disposta dal dpcm 11 marzo 2020
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091721068&partnerID=40&md5=8fbe638a2438ac5174f5c3c6360b430d
VL  - 27
ID  - 7783325
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the recent pandemic COVID-19, is reported to have originated from bats, with its intermediate host unknown to date. Here, we screened 26 animal counterparts of the human ACE2 (hACE2), the receptor for SARS-CoV-2 and SARS-CoV, and found that the ACE2s from various species, including pets, domestic animals and multiple wild animals, could bind to SARS-CoV-2 receptor binding domain (RBD) and facilitate the transduction of SARS-CoV-2 pseudovirus. Comparing to SARS-CoV-2, SARS-CoV seems to have a slightly wider range in choosing its receptor. We further resolved the cryo-electron microscopy (cryo-EM) structure of the cat ACE2 (cACE2) in complex with the SARS-CoV-2 RBD at a resolution of 3 A, revealing similar binding mode as hACE2 to the SARS-CoV-2 RBD. These results shed light on pursuing the intermediate host of SARS-CoV-2 and highlight the necessity of monitoring susceptible hosts to prevent further outbreaks. Copyright © 2020, The Author(s).
AD  - (Wu, Chen, Qiao, Tian, Du, Yan, Wang) CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China (Wu, Liu, Pan, Tian) University of Chinese Academy of Sciences, Beijing 100049, China (Chen, Wang) Institute of Physical Science and Information, Anhui University, Hefei, Anhui 230039, China (Liu, Zhang, Hu, Meng, Pan, Qi, Gao) CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China (Liu) Faculty of Health Sciences, University of Macau, Macau, SAR, China (Wang, Wang) Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center of Biological Structures, School of Life Sciences, Tsinghua University, Beijing 100084, China (Han) Department of biomedical engineering, Emory University, Atlanta, GA 10033, United States (Zhang) Laboratory of Protein Engineering and Vaccines,Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China (Hu) School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230026, China (Song) Research Network of Immunity and Health (RNIH), Beijing Institute of Life Science, Chinese Academy of Sciences, Beijing 100101, China (Shi) Key Laboratory of Etiology and Epidemiology of Emerging Infectious Diseases in Universities of Shandong, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, Shandong 27100, China (Qi, Yan, Wang) Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100049, China
J. Yan, CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. E-mail: yanjh@im.ac.cn Q. Wang, CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. E-mail: wangqihui@im.ac.cn H.-W. Wang, Ministry of Education Key Laboratory of Protein Sciences, Tsinghua-Peking Joint Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Beijing Frontier Research Center of Biological Structures, School of Life Sciences, Tsinghua University, Beijing 100084, China. E-mail: hongweiwang@tsinghua.edu.cn
AN  - 2006822882
AU  - Wu, L.
AU  - Chen, Q.
AU  - Liu, K.
AU  - Wang, J.
AU  - Han, P.
AU  - Zhang, Y.
AU  - Hu, Y.
AU  - Meng, Y.
AU  - Pan, X.
AU  - Qiao, C.
AU  - Tian, S.
AU  - Du, P.
AU  - Song, H.
AU  - Shi, W.
AU  - Qi, J.
AU  - Wang, H. W.
AU  - Yan, J.
AU  - Gao, G. F.
AU  - Wang, Q.
C1  - 10/6/2020
DA  - 01 Dec
DO  - http://dx.doi.org/10.1038/s41421-020-00210-9
IS  - 68
KW  - animal experiment
article
cat
cryoelectron microscopy
domestic animal
host range
human
intermediate host
nonhuman
receptor binding
Severe acute respiratory syndrome coronavirus 2
wild animal
LA  - English
PY  - 2020
SN  - 2056-5968
ST  - Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
T2  - Cell Discovery
TI  - Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2
UR  - http://www.nature.com/celldisc/
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006822882
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1038%2Fs41421-020-00210-9&issn=2056-5968&isbn=&volume=6&issue=1&spage=&pages=&date=2020&title=Cell+Discovery&atitle=Broad+host+range+of+SARS-CoV-2+and+the+molecular+basis+for+SARS-CoV-2+binding+to+cat+ACE2&aulast=Wu&pid=%3Cauthor%3EWu+L.%2CChen+Q.%2CLiu+K.%2CWang+J.%2CHan+P.%2CZhang+Y.%2CHu+Y.%2CMeng+Y.%2CPan+X.%2CQiao+C.%2CTian+S.%2CDu+P.%2CSong+H.%2CShi+W.%2CQi+J.%2CWang+H.-W.%2CYan+J.%2CGao+G.F.%2CWang+Q.%3C%2Fauthor%3E&%3CAN%3E2006822882%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 6 (1) (no pagination)
ID  - 7782790
ER  - 

TY  - JOUR
AB  - Coronavirus 2019 (COVID-19) captured worldwide attention as the virus spread from initial detection as a pneumonia of unknown cause in Wuhan, China in December 2019 to the declaration of a pandemic by the WHO only 3 months later. This paper describes the impact of COVID-19 on cardiac surgery services in the greater Los Angeles area. Discussion includes public health response to the pandemic, how local hospitals reacted to the expected surge in patients with COVID, the establishment of telemedicine services, and the projected future impact on California healthcare as a result of the COVID-19 pandemic.
AD  - Department of Cardiovascular Surgery, MemorialCare Heart and Vascular Institute, Long Beach, California, USA.
AN  - 33016521
AU  - Worthington, T.
AU  - Khoynezhad, A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/jocs.15042
DP  - NLM
ET  - 2020/10/06
J2  - Journal of cardiac surgery
KW  - Covid
cardiac surgery
pandemic
LA  - eng
N1  - 1540-8191
Worthington, Tiffany
Khoynezhad, Ali
Orcid: 0000-0002-9226-4227
Journal Article
Review
United States
J Card Surg. 2020 Oct 5. doi: 10.1111/jocs.15042.
PY  - 2020
SN  - 0886-0440
ST  - Los Angeles's perspective of COVID-19 effect and impact on cardiac surgery
T2  - Journal of cardiac surgery
TI  - Los Angeles's perspective of COVID-19 effect and impact on cardiac surgery
ID  - 7785208
ER  - 

TY  - JOUR
AB  - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak started with the detection of an increasing number of pneumonia cases of unknown origin in Wuhan, China, since December 2019. The disease caused by SAS-CoV-2 was subsequently named coronavirus disease 2019 (COVID-19). Currently, the ongoing COVID-19 pandemic poses a global health concern with more than 28.9 million confirmed cases, taking away the lives of more than 900,000 people worldwide. To prevent further spread of the disease, an understanding of the clinical characteristics and how the disease spread is essential, especially for an emerging disease like COVID-19. Individuals who are infected with SARS-CoV-2 show diverse clinical features, and the disease severity can range from asymptomatic to death. The disease has been shown to affect not just the respiratory system but also other systems of the body. This review will discuss the pulmonary and extra-pulmonary clinical manifestations of COVID-19 in general, as well as the clinical characteristics in different groups of patients such as children, the elderly, pregnant women, patients with comorbidities and those with a compromised immunity. It will also critically examine existing evidence from relevant studies and discuss the SARS-CoV-2 outbreak from an epidemiological perspective. With the easing of control measures in many countries after months of lockdown, it is important to revisit the lessons learnt from research, as the world enters a new normal with the coexistence of SARS-CoV-2. Copyright © 2020, Springer Nature Switzerland AG.
AD  - (Wong) Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, Petaling Jaya, Selangor 47810, Malaysia
R.S.Y. Wong, Faculty of Medicine, SEGi University, No. 9, Jalan Teknologi, Taman Sains Selangor, Kota Damansara, PJU 5, Petaling Jaya, Selangor 47810, Malaysia. E-mail: rebecca@segi.edu.my
AN  - 2006834958
AU  - Wong, R. S. Y.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1007/s42399-020-00546-z
DP  - Ovid Technologies
KW  - Clinical characteristics
covid-19
Epidemiological characteristics
Outbreak
Pandemic
SARS-CoV-2
adult
aged
article
child
China
clinical feature
comorbidity
coronavirus disease 2019
female
global health
human
immunity
nonhuman
pregnant woman
prevention
respiratory system
Severe acute respiratory syndrome coronavirus 2
LA  - English
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 2523-8973 (electronic)
2523-8973
ST  - The SARS-CoV-2 Outbreak: an Epidemiological and Clinical Perspective
T2  - SN Comprehensive Clinical Medicine
TI  - The SARS-CoV-2 Outbreak: an Epidemiological and Clinical Perspective
UR  - https://link.springer.com/journal/volumesAndIssues/42399
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006834958
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1007%2Fs42399-020-00546-z&issn=2523-8973&isbn=&volume=&issue=&spage=&pages=&date=2020&title=SN+Comprehensive+Clinical+Medicine&atitle=The+SARS-CoV-2+Outbreak%3A+an+Epidemiological+and+Clinical+Perspective&aulast=Wong&pid=%3Cauthor%3EWong+R.S.Y.%3C%2Fauthor%3E&%3CAN%3E2006834958%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
ID  - 7783110
ER  - 

TY  - JOUR
AB  - The unprecedented changes in our society because of COVID-19 and the fourth industrial revolution (4IR) shows that our healthcare system and the medical approach to psychotherapy can no longer meet the mental health needs of society. This paper first described the negative impact of COVID-19 and 4IR on our mental health. Then, following a brief critique of the medical model, this paper proposes that the future of psychotherapy needs to be based on the more inclusive and integrative framework of existential positive psychology (PP 2.0), which emphasizes flourishing through suffering. Finally, the paper emphasizes Viktor Frankl's cure and Wong's integrative meaning therapy. It concludes that integrative meaning therapy represents the future of psychotherapy, because it is situated in the area of interactions of at least three traditions: Clinical psychology, existential psychology, and positive psychology. This integrative model is holistic, recognising humans as bio-psycho-social-spiritual beings and considers several theoretical perspectives in both diagnosis and treatment.
AD  - Department of Psychology, Trent University, Peterborough, Canada.
AN  - 33016788
AU  - Wong, P. T. P.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/09540261.2020.1814703
DP  - NLM
ET  - 2020/10/06
J2  - International review of psychiatry (Abingdon, England)
KW  - Existential positive psychology (PP2.0)
Viktor Frankl
existential psychology
logotherapy
meaning therapy
positive psychology
psychiatry
LA  - eng
N1  - 1369-1627
Wong, Paul T P
Orcid: 0000-0003-4982-8127
Journal Article
England
Int Rev Psychiatry. 2020 Oct 5:1-14. doi: 10.1080/09540261.2020.1814703.
PY  - 2020
SN  - 0954-0261
SP  - 1-14
ST  - Existential positive psychology and integrative meaning therapy
T2  - International review of psychiatry (Abingdon, England)
TI  - Existential positive psychology and integrative meaning therapy
ID  - 7785179
ER  - 

TY  - JOUR
AD  - Department of Emergency Medicine, Baylor Scott and White All Saints Medical Center, Fort Worth, TX; Department of Emergency Medicine, John Peter Smith Hospital, Fort Worth, TX.
Department of Emergency Medicine, Baylor Scott and White All Saints Medical Center, Fort Worth, TX.
Department of Emergency Medicine, John Peter Smith Hospital, Fort Worth, TX.
AN  - 33012385
AU  - Wolfshohl, J.
AU  - Shedd, A.
AU  - Chou, E. H.
AU  - d'Etienne, J. P.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.annemergmed.2020.05.033
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Annals of emergency medicine
LA  - eng
N1  - 1097-6760
Wolfshohl, Jon
Shedd, Andrew
Chou, Eric H
d'Etienne, James P
Letter
United States
Ann Emerg Med. 2020 Oct;76(4):552-553. doi: 10.1016/j.annemergmed.2020.05.033. Epub 2020 May 28.
PY  - 2020
SN  - 0196-0644
SP  - 552-553
ST  - Lung Ultrasound for COVID-19 Evaluation in the Emergency Department: Is It Feasible?
T2  - Annals of emergency medicine
TI  - Lung Ultrasound for COVID-19 Evaluation in the Emergency Department: Is It Feasible?
VL  - 76
ID  - 7785582
ER  - 

TY  - JOUR
AB  - BACKGROUND: Few treatments exist for coronavirus disease 2019 (COVID-19). PURPOSE: To evaluate the effectiveness and harms of remdesivir for COVID-19. DATA SOURCES: Several databases, tables of contents of journals, and U.S. Food and Drug Administration and company websites were searched from 1 January through 31 August 2020. STUDY SELECTION: English-language, randomized trials of remdesivir treatments for adults with suspected or confirmed COVID-19. New evidence will be incorporated using living review methods. DATA EXTRACTION: Single-reviewer abstraction and risk-of-bias assessment verified by a second reviewer; GRADE (Grading of Recommendations Assessment, Development and Evaluation) methods used for certainty-of-evidence assessments. DATA SYNTHESIS: Four randomized trials were included. In adults with severe COVID-19, remdesivir compared with placebo probably improves recovery by a large amount (absolute risk difference [ARD] range, 7% to 10%) and may result in a small reduction in mortality (ARD range, -4% to 1%) and a shorter time to recovery or clinical improvement. Remdesivir may have little to no effect on hospital length of stay. Remdesivir probably reduces serious adverse events by a moderate amount (ARD range, -6% to -8%). Compared with a 10-day remdesivir course, a 5-day course may reduce mortality, increase recovery or clinical improvement by small to moderate amounts, reduce time to recovery, and reduce serious adverse events among hospitalized patients not requiring mechanical ventilation. Recovery due to remdesivir may not vary by age, sex, symptom duration, or disease severity. LIMITATIONS: Low-certainty evidence with few published trials, including 1 preliminary report and 2 open-label trials. Trials excluded pregnant women and adults with severe kidney or liver disease. CONCLUSION: In hospitalized adults with COVID-19, remdesivir probably improves recovery and reduces serious adverse events and may reduce mortality and time to clinical improvement. For adults not receiving mechanical ventilation or extracorporeal membrane oxygenation, a 5-day course of remdesivir may provide similar benefits to and fewer harms than a 10-day course. PRIMARY FUNDING SOURCE: U.S. Department of Veterans Affairs, Veterans Health Administration Office of Research and Development, Health Services Research and Development Service, and Evidence Synthesis Program.
AD  - Minneapolis VA Evidence Synthesis Program, Center for Care Delivery and Outcomes Research, and University of Minnesota School of Medicine, Minneapolis, Minnesota (T.J.W.).
Minneapolis VA Section of Infectious Diseases and University of Minnesota School of Medicine, Minneapolis, Minnesota (A.S.K.).
Minneapolis VA Evidence Synthesis Program, Center for Care Delivery and Outcomes Research, Minneapolis, Minnesota (R.M., N.G.).
VA Portland Health Care System and Oregon Health & Science University School of Medicine, Portland, Oregon (A.O.).
Minneapolis VA Evidence Synthesis Program, Center for Care Delivery and Outcomes Research and University of Minnesota School of Medicine, Minneapolis, Minnesota (W.D.).
AN  - 33017170
AU  - Wilt, T. J.
AU  - Kaka, A. S.
AU  - MacDonald, R.
AU  - Greer, N.
AU  - Obley, A.
AU  - Duan-Porter, W.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.7326/m20-5752
DP  - NLM
ET  - 2020/10/06
J2  - Annals of internal medicine
LA  - eng
N1  - 1539-3704
Wilt, Timothy J
Kaka, Anjum S
MacDonald, Roderick
Greer, Nancy
Obley, Adam
Duan-Porter, Wei
Journal Article
United States
Ann Intern Med. 2020 Oct 5. doi: 10.7326/M20-5752.
PY  - 2020
SN  - 0003-4819
ST  - Remdesivir for Adults With COVID-19 : A Living Systematic Review for an American College of Physicians Practice Points
T2  - Annals of internal medicine
TI  - Remdesivir for Adults With COVID-19 : A Living Systematic Review for an American College of Physicians Practice Points
ID  - 7785159
ER  - 

TY  - JOUR
AB  - Amelioration of immune overactivity during sepsis is key to restoring hemodynamics, microvascular blood flow, and tissue oxygenation, and in preventing multi-organ dysfunction syndrome. The systemic inflammatory response syndrome that results from sepsis ultimately leads to degradation of the endothelial glycocalyx and subsequently increased vascular leakage. Current fluid resuscitation techniques only transiently improve outcomes in sepsis, and can cause edema. Nitric oxide (NO) treatment for sepsis has shown promise in the past, but implementation is difficult due to the challenges associated with delivery and the transient nature of NO. To address this, we tested the anti-inflammatory efficacy of sustained delivery of exogenous NO using IV infused NO releasing nanoparticles (NO-np). The impact of NO-np on microhemodynamics and immune response in a lipopolysaccharide (LPS) induced endotoxemia mouse model was evaluated. NO-np treatment significantly attenuated the pro-inflammatory response by promoting M2 macrophage repolarization, which reduced the presence of pro-inflammatory cytokines in the serum and slowed vascular extravasation. Combined, this resulted in significantly improved microvascular blood flow and 72-hour survival of animals treated with NO-np. The results from this study suggest that sustained supplementation of endogenous NO ameliorates and may prevent the morbidities of acute systemic inflammatory conditions. Given that endothelial dysfunction is a common denominator in many acute inflammatory conditions, it is likely that NO enhancement strategies may be useful for the treatment of sepsis and other acute inflammatory insults that trigger severe systemic pro-inflammatory responses and often result in a cytokine storm, as seen in COVID-19.
AD  - Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093.
Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY, 10461.
Department of Dermatology, George Washington University School of Medicine, Washington DC.
Department of Bioengineering, University of California San Diego, La Jolla, CA, 92093. Electronic address: pcabrales@ucsd.edu.
AN  - 33011274
AU  - Williams, A. T.
AU  - Muller, C. R.
AU  - Govender, K.
AU  - Navati, M. S.
AU  - Friedman, A. J.
AU  - Friedman, J. M.
AU  - Cabrales, P.
C1  - 10/6/2020
C2  - PMC7529593
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.freeradbiomed.2020.09.025
DP  - NLM
ET  - 2020/10/05
J2  - Free radical biology & medicine
KW  - Inflammation
cytokine storm
nitric oxide
sepsis
septic shock
vascular permeability
production and use of nitric-oxide releasing nanoparticles. All other authors
declare no conflicts of interest related to the work presented in this manuscript.
LA  - eng
N1  - 1873-4596
Williams, Alexander T
Muller, Cynthia R
Govender, Krianthan
Navati, Mahantesh S
Friedman, Adam J
Friedman, Joel M
Cabrales, Pedro
Journal Article
Free Radic Biol Med. 2020 Oct 1;161:15-22. doi: 10.1016/j.freeradbiomed.2020.09.025.
PY  - 2020
SN  - 0891-5849 (Print)
0891-5849
SP  - 15-22
ST  - Control of systemic inflammation throughearly nitric oxide supplementation with nitric oxide releasing nanoparticles
T2  - Free radical biology & medicine
TI  - Control of systemic inflammation throughearly nitric oxide supplementation with nitric oxide releasing nanoparticles
VL  - 161
ID  - 7785685
ER  - 

TY  - JOUR
AB  - Natalie Wieland has been delivering online learning for over 15 years as both a lecturer and workplace trainer. In her paper, she reflects on how digital learning has evolved from the days of moving PowerPoints to the highly polished and produced modules with an equally high price. Natalie reviews the first response during COVID-19 when so many rushed to deliver their content online, using tools such as Zoom. Natalie also provides her thoughts on what we have learned during this period, including the need to provide synchronous and asynchronous learning, the need to include the educator in the process and empower them with digital tools to create online content and the need to make online learning authentic and not over produced. It is still content and design that is critical. She also offers some predictions around what the future will look like with digital learning in the workplace, with lessons we have all learned.
AN  - 2448236982
AU  - Wieland, Natalie
AU  - Kollias, Liz
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DP  - ProQuest Central
IS  - 2
KW  - Education
digital workplace learning
digital learning first response during covid-19
empowering educators
digital learning post covid-19
Coronaviruses
Distance learning
COVID-19
LA  - English
N1  - Copyright - © 2020. This work is published under https://creativecommons.org/licenses/by/3.0/at/deed.en (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SP  - 84-92
ST  - Online Learning Before, During and After COVID-19: Observations Over 20 Years
T2  - International Journal of Advanced Corporate Learning
TI  - Online Learning Before, During and After COVID-19: Observations Over 20 Years
UR  - https://www.proquest.com/docview/2448236982?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Online+Learning+Before%2C+During+and+After+COVID-19%3A+Observations+Over+20+Years&title=International+Journal+of+Advanced+Corporate+Learning&issn=&date=2020-01-01&volume=13&issue=2&spage=84&au=Wieland%2C+Natalie%3BKollias%2C+Liz&isbn=&jtitle=International+Journal+of+Advanced+Corporate+Learning&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 13
ID  - 7784949
ER  - 

TY  - JOUR
AB  - BACKGROUND: autoimmune patients can be more susceptible to infection. Proper knowledge, perception, and practices towards COVID-19 are essential for these patients during pandemic. This study aimed to know their knowledge, perception, and practices regarding COVID-19. METHODS: cross sectional study using online survey was conducted from April to May 2020. Patients with autoimmune disease were asked about demographic characteristics, diagnosis, history of treatment, knowledge, perception, and practice regarding COVID-19. RESULTS: there were 685 respondents. Most of them were female and had systemic lupus erythematosus with median age of 37 years old. Almost all respondents had good knowledge regarding transmission of COVID-19 and did proper prevention practices. Adequacy of information and steroid or mycophenolate mofetil/mycophenolic acid (MMF/MPA) use were related to perception of the effect of pandemic to their own health. Visiting private clinic and receiving hydroxychloroquine/chloroquine sulfate or sulfasalazine were related to perception that autoimmune conditions would make them more prone to COVID-19. Work from home was related to perception that when contracting COVID-19, the symptoms would be more severe. Living in Sumatra region and getting hydroxychloroquine/chloroquine sulfate or MMF/MPA were related to perception that autoimmune medications could reduce risk of getting COVID-19. Adequate information, university education, private clinic visit, and hydroxychloroquine/chloroquine sulfate use were related to perception that COVID-19 pandemic would cause difficulties in getting medications. CONCLUSION: almost all respondents had good knowledge and practices regarding COVID-19. Adequacy of information, autoimmune treatment, work from home, educational background, area of living, and health care facilities contributed to perception regarding COVID-19 pandemic.
AD  - Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo Hospital Jakarta, University of Indonesia Hospital, Indonesia. alvina.widhani@gmail.com.
AN  - 33020333
AU  - Widhani, A.
AU  - Rengganis, I.
AU  - Susanto, A. J.
AU  - Surachmanto, E. E.
AU  - Hasibuan, A. S.
AU  - Fetarayani, D.
AU  - Mulya, D. P.
AU  - Kurniati, N.
AU  - Yunihastuti, E.
AU  - Masri, R.
AU  - Karjadi, T. H.
AU  - Koesnoe, S.
AU  - Zubir, Z.
AU  - Alimudin, S.
AU  - Estiasari, R.
AU  - Safri, A. Y.
AU  - Maria, S.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
autoimmune
knowledge
perception
practice
LA  - eng
N1  - Widhani, Alvina
Rengganis, Iris
Susanto, Agus Joko
Surachmanto, Eko E
Hasibuan, Anshari Saifuddin
Fetarayani, Deasy
Mulya, Deshinta Putri
Kurniati, Nova
Yunihastuti, Evy
Masri, Raveinal
Karjadi, Teguh Harjono
Koesnoe, Sukamto
Zubir, Zuhrial
Alimudin, Suriani
Estiasari, Riwanti
Safri, Ahmad Yanuar
Maria, Suzy
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):214-226.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 214-226
ST  - Factors Related to Knowledge, Perception, and Practices Towards COVID-19 Among Patients with Autoimmune Diseases: A Multicenter Online Survey
T2  - Acta medica Indonesiana
TI  - Factors Related to Knowledge, Perception, and Practices Towards COVID-19 Among Patients with Autoimmune Diseases: A Multicenter Online Survey
VL  - 52
ID  - 7785035
ER  - 

TY  - JOUR
AB  - The achievements of vaccine research and development bring a hope to our societies that we may cope with the COVID-19 pandemic. There are two aspects that should be maintained in balance: the immediate necessity for speed of vaccine research and the inherent need for protection of research subjects, which is the foremost concern of research ethics. This narrative review highlights ethical issues in COVID-19 vaccine research and development that every stakeholder needs to be aware of and to consider.
AD  - Department of Microbiology, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Medical and Health Research Ethics Committee, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada / Dr, Sardjito General Hospital, Yogyakarta, Indonesia.
AN  - 33012020
AU  - Wibawa, T.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/tmi.13503
DP  - NLM
ET  - 2020/10/05
J2  - Tropical medicine & international health : TM & IH
KW  - Covid-19
Ethics
Vaccine research
LA  - eng
N1  - 1365-3156
Wibawa, Tri
Journal Article
England
Trop Med Int Health. 2020 Oct 4. doi: 10.1111/tmi.13503.
PY  - 2020
SN  - 1360-2276
ST  - COVID-19 Vaccine Research and Development: Ethical Issues
T2  - Tropical medicine & international health : TM & IH
TI  - COVID-19 Vaccine Research and Development: Ethical Issues
ID  - 7785629
ER  - 

TY  - JOUR
AD  - Department of Population Medicine, Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston (Wen); Department of Health Policy and Management, Harvard T. H. Chan School of Public Health, Boston (Barnett); Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Baltimore (Saloner). Tami L. Mark, Ph.D., and Alexander J. Cowell, Ph.D., are editors of this column.
AN  - 33019859
AU  - Wen, H.
AU  - Barnett, M. L.
AU  - Saloner, B.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1176/appi.ps.202000215
DP  - NLM
ET  - 2020/10/07
J2  - Psychiatric services (Washington, D.C.)
KW  - Covid-19
chronic disease
risk factor
substance use disorder
LA  - eng
N1  - 1557-9700
Wen, Hefei
Barnett, Michael L
Saloner, Brendan
Journal Article
United States
Psychiatr Serv. 2020 Oct 6:appips202000215. doi: 10.1176/appi.ps.202000215.
PY  - 2020
SN  - 1075-2730
SP  - appips202000215
ST  - Clinical Risk Factors for COVID-19 Among People With Substance Use Disorders
T2  - Psychiatric services (Washington, DC)
TI  - Clinical Risk Factors for COVID-19 Among People With Substance Use Disorders
ID  - 7785081
ER  - 

TY  - JOUR
AB  - The proposal of "The Belt and Road" (The B&R) Initiative has promoted regional economic cooperation and financial integration. It is crucial to measure the volatility spillover effects among "The B&R" currency market. Results from the time-varying spillover model show that "The B&R" system spillover index reflects some sudden regional crises. Likewise, the spillover of RMB exchange rate is affected by internal financial reforms as well as external economic shocks. Further, the recent outbreak of the COVID-19 has disrupted this system and the influence of RMB.
AD  - Business School, China University of Political Science and Law, Beijing, 102249, China.
Geisel School of Medicine, Dartmouth College, Hanover, NH 03755, USA.
School of Economics and Management, University of Chinese Academy of Sciences, Beijing, 100190, China.
Key Laboratory of Big Data Mining and Knowledge Management, Chinese Academy of Sciences, 100190, China.
Research Center on Fictitious Economy & Data Science, Chinese Academy of Sciences, 100190, China.
AN  - 33013238
AU  - Wei, Z.
AU  - Luo, Y.
AU  - Huang, Z.
AU  - Guo, K.
C1  - 10/6/2020
C2  - PMC7525334
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.frl.2020.101782
DP  - NLM
ET  - 2020/10/06
J2  - Finance research letters
KW  - Covid-19
Exchange rate
Spillover effect
The belt and road
LA  - eng
N1  - 1544-6131
Wei, Zhixi
Luo, Yu
Huang, Zili
Guo, Kun
Journal Article
Financ Res Lett. 2020 Sep 30:101782. doi: 10.1016/j.frl.2020.101782.
PY  - 2020
SN  - 1544-6123 (Print)
1544-6131
SP  - 101782
ST  - Spillover Effects of RMB Exchange Rate among B&R Countries: before and during COVID-19 Event
T2  - Finance research letters
TI  - Spillover Effects of RMB Exchange Rate among B&R Countries: before and during COVID-19 Event
ID  - 7785477
ER  - 

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVES: SARS-CoV-2 is known to cause milder disease in children when compared with adults, but the extent of this is unclear. The aim of this article is to estimate the case fatality rate (CFR) for SARS-CoV-2 infection and SARS-CoV-2 pneumonia in young children aged 5 years, and compare this with estimated CFRs for respiratory syncytial virus (RSV) and influenza. METHOD: This article reviews published case series of SARS-CoV-2 infection in the paediatric population and epidemiological data on COVID-19 published on official government websites internationally and in Australia. RESULTS: The CFR of SARS-CoV-2 pneumonia in children aged 5 years is estimated to be 0.15-1.35%, which is lower than the estimated CFR of RSV pneumonia of 0.3-2.1%, but higher than the estimated CFR of influenza pneumonia of 0.14-0.45%. DISCUSSION: SARS-CoV-2 infection is likely to be less lethal than RSV in children aged 5 years, but more lethal than influenza.
AD  - MBBS, BMedSc, FRACGP, DCH, Principal GP, Standish Street Surgery, Vic; Visiting Medical Officer, Alpine Health, Vic.
AN  - 33015684
AU  - Wei, J. S.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.31128/ajgp-04-20-5357
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Australian journal of general practice
LA  - eng
N1  - 2208-7958
Wei, James Shunxian
Journal Article
Australia
Aust J Gen Pract. 2020 Oct;49(10):683-686. doi: 10.31128/AJGP-04-20-5357.
PY  - 2020
SP  - 683-686
ST  - How lethal is SARS-CoV-2 pneumonia when compared with respiratory syncytial virus and influenza in young children?
T2  - Australian journal of general practice
TI  - How lethal is SARS-CoV-2 pneumonia when compared with respiratory syncytial virus and influenza in young children?
VL  - 49
ID  - 7785259
ER  - 

TY  - JOUR
AB  - Early detection of acute pulmonary embolism (PE) in patients with SARS-CoV-2 infection is integral to the clinical management of these patients. Many recently published studies have evaluated incidence of PE in hospitalized patients with COVID-19(1-9) , however there is relatively limited data describing patients with SARS-CoV-2 infection and concomitant diagnosis of acute PE upon initial presentation. Therefore, the purpose of this study is to (i) evaluate the incidence of acute pulmonary embolism (PE) in patients undergoing computed tomography pulmonary angiography (CTPA) in the emergency department (ED) across six hospitals in New York City during the height of the COVID-19 pandemic compared to a non-pandemic period, and (ii) compare the characteristics and early outcomes of patients presenting with PE during the pandemic (n=87) to patients presenting with PE during a non-pandemic period (n=34).
AD  - Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, New York, USA.
Department of Surgery, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1259, New York, New York, USA.
Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1234, New York, New York, USA.
Department of Medicine, Division of Cardiology, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1030, New York, New York, USA.
AN  - 33015866
AU  - Watchmaker, J. M.
AU  - Goldman, D. T.
AU  - Lee, J. Y.
AU  - Choi, S.
AU  - Mills, A. C.
AU  - Toussie, D.
AU  - Finkelstein, M.
AU  - Sher, A. R.
AU  - Jacobi, A. H.
AU  - Bernheim, A. M.
AU  - Chung, M. S.
AU  - Eber, C. D.
AU  - Lookstein, R. A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/acem.14148
DP  - NLM
ET  - 2020/10/06
J2  - Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
LA  - eng
N1  - 1553-2712
Watchmaker, Jennifer M
Orcid: 0000-0003-4320-0021
Goldman, Daryl T
Lee, Jun Y
Choi, Seulah
Mills, Ariana C
Toussie, Danielle
Finkelstein, Mark
Sher, Alex R
Jacobi, Adam H
Bernheim, Adam M
Chung, Michael S
Eber, Corey D
Lookstein, Robert A
Letter
United States
Acad Emerg Med. 2020 Oct 5. doi: 10.1111/acem.14148.
PY  - 2020
SN  - 1069-6563
ST  - Increased Incidence of Acute Pulmonary Embolism in Emergency Department Patients During the COVID-19 Pandemic
T2  - Academic emergency medicine : official journal of Society for Academic Emergency Medicine
TI  - Increased Incidence of Acute Pulmonary Embolism in Emergency Department Patients During the COVID-19 Pandemic
ID  - 7785238
ER  - 

TY  - JOUR
AB  - INTRODUCTION AND AIMS: COVID-19, considered a pandemic by the World Health Organization, overwhelmed hospitals in the USA. In parallel to the growing pandemic, alcohol sales grew in the USA, with people stockpiling alcohol. Alcohol-induced blackouts are one particularly concerning consequence of heavy drinking, and the extent to which blackout prevalence may change in the context of a pandemic is unknown. The purpose of the current study is to describe the prevalence of publicly available tweets in the USA referencing alcohol-induced blackouts prior to and during the COVID-19 outbreak. DESIGN AND METHODS: We used Crimson Hexagon's ForSight tool to access all original English tweets written in the USA that referenced alcohol-related blackouts in 2019 and 2020. Using infoveillance methods, we tracked changes in the number and proportion of tweets about blackouts. RESULTS: More alcohol-related blackout tweets were written between 13 March and 24 April in 2020 than 2019. In addition, a greater proportion of all tweets referenced blackouts in 2020 than in 2019. In the period prior to the 'stay at home' orders (January to mid-March), the proportion of blackout tweets were higher in 2020 than 2019. DISCUSSION AND CONCLUSION: Our findings demonstrate that references to high-risk drinking persist during the pandemic despite restrictions on large social gatherings. Given that the internet is a common source of information for COVID-19, the frequent posting about blackouts during this period might normalise the behaviour. This is concerning because alcohol use increases susceptibility to COVID-19, and alcohol-related mortality can further tax hospital resources.
AD  - Department of Kinesiology and Health, Miami University, Oxford, USA.
Discipline of Addiction Medicine, Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Department of Behavioral and Social Sciences, Centre for Alcohol and Addiction Studies, Brown University School of Public Health, Providence, USA.
Pharmacology: School of Medical Sciences, The University of Sydney, Sydney, Australia.
AN  - 33020967
AU  - Ward, R. M.
AU  - Riordan, B. C.
AU  - Merrill, J. E.
AU  - Raubenheimer, J.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/dar.13186
DP  - NLM
ET  - 2020/10/07
J2  - Drug and alcohol review
KW  - Covid-19
Twitter
alcohol
blackout
pandemic
LA  - eng
N1  - 1465-3362
Ward, Rose Marie
Orcid: 0000-0001-8154-8163
Riordan, Benjamin C
Orcid: 0000-0002-7805-0652
Merrill, Jennifer E
Orcid: 0000-0002-8310-140x
Raubenheimer, Jacques
Orcid: 0000-0003-3907-304x
WHO_/World Health Organization/International
Journal Article
Australia
Drug Alcohol Rev. 2020 Oct 6. doi: 10.1111/dar.13186.
PY  - 2020
SN  - 0959-5236
ST  - Describing the impact of the COVID-19 pandemic on alcohol-induced blackout tweets
T2  - Drug and alcohol review
TI  - Describing the impact of the COVID-19 pandemic on alcohol-induced blackout tweets
ID  - 7784966
ER  - 

TY  - JOUR
AB  - The original article was published with errors in some sentences. The correct sentences are provided in this correction. The word “rate�?in the sentence “It follows that β(t)/μ(t) is the effective reproduction rate: the total number...�?under the section �?The compartmental model of infectious disease dynamics�?should read as “number�? The sentence “The F-test is achieved through the following algorithm�?below the equation 20 should read as “The F-test is achieved through the application of Algorithm 2�? Also, under the section �?.1 Systemidentification and ODE-constrained Optimization�? the word “rate�?in the sentence �?..rapid decline of the effective reproduction rate, r0(t).�?in the third paragraph should read as number�? The word “East�?in the sentence “By contrast, Washtenaw County, about 50 km to the East, but�?in the fourth paragraph should read as “west�? Under the section �?.2 Deep and Bayesian neural networks�?the word “Appendix�?in the sentence “Regions are given in Appendix...�?in fourth paragraph should read as “Appendices�?In the fifth paragraph, theword “rate�?in the sentence “The effective reproduction rate r0(t)...�?should read as “number�?and the word “Appendix�?in the sentence “The regional results in Appendix “DNN�?should read as “Appendices�? The word “rate�?in the caption of Fig. 6 “Parameters of time-dependent SIRD coefficients, β(t), μ(t), ��(t), and the effective reproduction rate, r0(t), for Regions 1�? (see Fig. 1) of Michigan�?should read as “number�? In the seventh paragraph, the word “rate�?in the sentence �?..effective reproduction rate r0(t)�?should read as “number�? The Eqs. 43, 44 and 45 was published incorrectly. The correct equations are provided below. Ds(t) = θ 16 + θ 17t + θ 18t2 + θ 19t3 (43) Di(t) = θ 20 + θ 21t + θ 22t2 + θ 23t3 (44) Dr(t) = θ 24 + θ 25t + θ 26t2 + θ 27t3 (45) The word “rate�?under the section �?.3 Results of system identification of two dimensional SIRDmodel with diffusion�?in the fourth line should read as “number�?and the sentence “While the preliminary nature of these warrants caution...�?should read as “While the preliminary nature of these results warrants caution..�? The word “open�?in the caption of Fig. 16 “Regions 1�?: Time-dependent coefficients identified by DNNs, where an increased infection rate after the open (O) of lockdown on June 1st is observed�?should read as “opening�? The word “open�?in the caption of Fig. 18 “Regions 1�?8: Time-dependent coefficients identified by BNNs, where an increased infection rate after the open (O) of lockdown on June 1st is observed. Bands correspond to �u standard deviation over the mean�?should read as “opening�? Original article has been corrected. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
AD  - Mechanical Engineering, Mathematics and the Michigan Institute for Computational, Discovery and Engineering, University of Michigan, Ann Arbor, United States
AU  - Wang, Z.
AU  - Zhang, X.
AU  - Teichert, G. H.
AU  - Carrasco-Teja, M.
AU  - Garikipati, K.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s00466-020-01925-y
J2  - Comput Mech
LA  - English
M3  - Erratum
N1  - Export Date: 6 October 2020
CODEN: CMMEE
Correspondence Address: Garikipati, K.; Mechanical Engineering, Mathematics and the Michigan Institute for Computational, Discovery and Engineering, University of MichiganUnited States; email: krishna@umich.edu
PY  - 2020
SN  - 01787675 (ISSN)
ST  - Correction to: System inference for the spatio-temporal evolution of infectious diseases: Michigan in the time of COVID-19 (Computational Mechanics, (2020), 10.1007/s00466-020-01894-2)
T2  - Computational Mechanics
TI  - Correction to: System inference for the spatio-temporal evolution of infectious diseases: Michigan in the time of COVID-19 (Computational Mechanics, (2020), 10.1007/s00466-020-01894-2)
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091727311&doi=10.1007%2fs00466-020-01925-y&partnerID=40&md5=e6325661f641463abb9d31d435daf2b9
ID  - 7783336
ER  - 

TY  - JOUR
AB  - Objective: The aim of this study is to apply the advanced error-trend-seasonal (ETS) framework to forecast the prevalence and mortality series of COVID-19 in the USA, the UK, Russia, and India, and the predictive performance of the ETS framework was compared with the most frequently used autoregressive integrated moving average (ARIMA) model. Material(s) and Method(s): The prevalence and mortality data of COVID-19 in the USA, the UK, Russia, and India between 20 February 2020 and 15 May 2020 were extracted from the WHO website. Then, the data subsamples between 20 February 2020 and 3 May 2020 were treated as the training horizon, and the others were used as the testing horizon to construct the ARIMA models and the ETS models. Result(s): Based on the model evaluation criteria, the ARIMA (0,2,1) and ETS (M,MD,N), sparse coefficient ARIMA (0,2,(1,6)) and ETS (A,AD,M), ARIMA (1,1,1) and ETS (A,MD, A), together with ARIMA (2,2,1) and ETS (A,M,A) specifications were identified as the preferred ARIMA and ETS models for the prevalence data in the USA, the UK, Russia, and India, respectively; the ARIMA (0,2,1) and ETS (M,A,M), ARIMA (0,2,1) and ETS (M,A, N), ARIMA (0,2,1) and ETS (A,A,N), coupled with ARIMA (0,2,2) and ETS (M,M,N) specifications were selected as the optimal ARIMA and ETS models for the mortality data in these four countries, respectively. Among these best-fitting models, the ETS models produced smaller forecasting error rates than the ARIMA models in all the datasets. Conclusion(s): The ETS framework can be used to nowcast and forecast the long-term temporal trends of the COVID-19 prevalence and mortality in the USA, the UK, Russia, and India, and which provides a notable performance improvement over the most frequently used ARIMA model. Our findings can aid governments as a reference to prepare for and respond to the COVID-19 pandemic both in restricting the transmission of the disease and in lowering the disease-related deaths in the upcoming days. Copyright © 2020 Wang et al.
AD  - (Wang, Yao, Zhao, Li, Zhao) Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China (Xu) Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing, China (Wang) Center for Musculoskeletal Surgery, Charite Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin, Humboldt-Universitat Zu Berlin and Berlin Institute of Health, Berlin, Germany
Y. Wang, Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, China. E-mail: wybwho@163.com
AN  - 2005153203
AU  - Wang, Y.
AU  - Xu, C.
AU  - Yao, S.
AU  - Zhao, Y.
AU  - Li, Y.
AU  - Wang, L.
AU  - Zhao, X.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.2147/IDR.S265292
DP  - Ovid Technologies
KW  - ARIMA model
Coronavirus disease 2019
Epidemiological indicators
ETS model
Nowcasting
Outbreak
article
controlled study
forecasting
government
human
India
mortality
pandemic
prevalence
Russian Federation
LA  - English
PY  - 2020
SN  - 1178-6973 (electronic)
1178-6973
SP  - 3335-3350
ST  - Estimating the prevalence and mortality of coronavirus disease 2019 (COVID-19) in the USA, the UK, Russia, and India
T2  - Infection and Drug Resistance
TI  - Estimating the prevalence and mortality of coronavirus disease 2019 (COVID-19) in the USA, the UK, Russia, and India
UR  - https://www.dovepress.com/getfile.php?fileID=61914
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005153203
VL  - 13
ID  - 7782981
ER  - 

TY  - JOUR
AD  - Department of Epidemiology and Health Statistics, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province, P.R. China.
Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing, P.R. China.
AN  - 33012300
AU  - Wang, Y.
AU  - Xu, C.
AU  - Yao, S.
AU  - Zhao, Y.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1017/s095026882000237x
DP  - NLM
ET  - 2020/10/06
J2  - Epidemiology and infection
LA  - eng
N1  - 1469-4409
Wang, Yongbin
Orcid: 0000-0001-7854-7020
Xu, Chunjie
Yao, Sanqiao
Zhao, Yingzheng
Journal Article
England
Epidemiol Infect. 2020 Oct 5:1-30. doi: 10.1017/S095026882000237X.
PY  - 2020
SN  - 0950-2688
SP  - 1-30
ST  - Forecasting the epidemiological trends of COVID-19 prevalence and mortality using the advanced ��-Sutte Indicator
T2  - Epidemiology and infection
TI  - Forecasting the epidemiological trends of COVID-19 prevalence and mortality using the advanced ��-Sutte Indicator
ID  - 7785602
ER  - 

TY  - JOUR
AB  - In the original version of this article, an incorrect version of Fig. 1B was published. Figure 1B has now been replaced with the corrected version. This has been corrected in both the PDF and HTML versions of this article. The original, incorrect version of Fig. 1B is displayed below for reference.(figure presented). Copyright © 2020, Springer Nature Limited.
AD  - (Wang, Xu) Center for Artificial Intelligence in Drug Discovery, School of Medicine, Case Western Reserve University, Cleveland, OH, United States (Kaelber) Departments of Internal Medicine and Pediatrics and the Center for Clinical Informatics Research and Education, The MetroHealth System, Cleveland, OH, United States (Volkow) National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, United States
R. Xu, Center for Artificial Intelligence in Drug Discovery, School of Medicine, Case Western Reserve University, Cleveland, OH, United States. E-mail: rxx@case.edu N.D. Volkow, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, United States. E-mail: nvolkow@nida.nih.gov
AN  - 2006835238
AU  - Wang, Q. Q.
AU  - Kaelber, D. C.
AU  - Xu, R.
AU  - Volkow, N. D.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1038/s41380-020-00895-0
DP  - Ovid Technologies
KW  - erratum
LA  - English
M3  - Erratum
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 1359-4184
1476-5578
ST  - Correction to: COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States (Molecular Psychiatry, (2020), 10.1038/s41380-020-00880-7)
T2  - Molecular Psychiatry
TI  - Correction to: COVID-19 risk and outcomes in patients with substance use disorders: analyses from electronic health records in the United States (Molecular Psychiatry, (2020), 10.1038/s41380-020-00880-7)
UR  - http://www.nature.com/mp/index.html
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006835238
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1038%2Fs41380-020-00895-0&issn=1359-4184&isbn=&volume=&issue=&spage=&pages=&date=2020&title=Molecular+Psychiatry&atitle=Correction+to%3A+COVID-19+risk+and+outcomes+in+patients+with+substance+use+disorders%3A+analyses+from+electronic+health+records+in+the+United+States+%28Molecular+Psychiatry%2C+%282020%29%2C+10.1038%2Fs41380-020-00880-7%29&aulast=Wang&pid=%3Cauthor%3EWang+Q.Q.%2CKaelber+D.C.%2CXu+R.%2CVolkow+N.D.%3C%2Fauthor%3E&%3CAN%3E2006835238%3C%2FAN%3E&%3CDT%3EErratum%3C%2FDT%3E
ID  - 7783101
ER  - 

TY  - JOUR
AB  - BACKGROUND The prognostic value of coagulation disorder in coronavirus disease 2019 (COVID-19) patients should be demonstrated. AIM To investigate the abnormalities of coagulation parameters in the patients with COVID-19 and their prognostic values. METHODS Consecutive patients admitted in the isolation ward of Renmin Hospital of Wuhan University from January 31 to February 5, 2020 with confirmed COVID-19 were included. The primary outcomes were death and survival as of March 11. Demographics, vital signs, comorbidities and laboratory tests were collected and compared between those who died and survivors. Logistic regression analysis for prognostic factors was performed. Kaplan-Meier analysis was used to compare the estimated survival rate between patients with prolonged prothrombin time and normal prothrombin time. RESULTS The total number of patients with confirmed COVID-19 who were enrolled was 213. The median age was 62 years, and 95 patients (44.6%) were men. Fifty-one patients were critical (23.9%), 79 patients were severe (37.1%) and 83 patients were moderate (39%). As of March 11, 2020, 99 patients were discharged (46.5%), 79 patients (37.1%) stayed in the hospital and 35 patients (16.2%) died. Median time to death was 6 (4-8) d, while median hospital stay was 32 (22-36) d in survivors (P  0.001). More men (P = 0.002) and elderly patients (P  0.001) were found in the group of those who died. The respiration rate at admission was higher in the group of those who died (P  0.001). The incidences of hypertension (P = 0.028), cerebrovascular disease (P  0.001), chronic kidney disease (P = 0.02) and chronic obstructive pulmonary disease (P  0.001) were higher in the group of those who died. Platelet count was decreased in the group of those who died (P = 0.002) whereas prothrombin time (P  0.001), activated partial thromboplastin time (P = 0.033), concentration of D-dimer (P  0.001) and fibrin degradation products (P  0.001) were increased in the group of those who died. Prothrombin time [odds ratio (OR): 2.19, P = 0.004], respiration rate (OR: 1.223, P  0.001), age (OR: 1.074, P  0.001) and fibrin degradation products concentration (OR: 1.02, P = 0.014) were predictors of death. The survival rate was significantly lower in patients with prolonged prothrombin time compare to those with normal prothrombin time (P  0.001). CONCLUSION Prothrombin time, concentration of fibrin degradation products, respiration rate and age were predictive factors for clinical outcomes of COVID-19 patients. Copyright © The Author(s) 2020.
AD  - (Wang, He, Yu, Jiang) Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province 430060, China (Wang, He, Yu, Jiang) Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei Province 430060, China (Wang, He, Yu, Jiang) Hubei Key Laboratory of Cardiology, Wuhan, Hubei Province 430060, China (Hu) School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney 2052, Australia
H. Jiang, Department of Cardiology, Renmin Hospital of Wuhan University, No. 238 Jiefang Road, District of Wuchang, Wuhan, Hubei Province 430060, China. E-mail: hong-jiang@whu.edu.cn
AN  - 632998319
AU  - Wang, L.
AU  - He, W. B.
AU  - Yu, X. M.
AU  - Hu, D. L.
AU  - Jiang, H.
C1  - 10/6/2020
DA  - 01 Oct
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i19.4370
DP  - Ovid Technologies
IS  - 19
KW  - Coagulation
covid-19
Fibrin degradation products
Infectious disease
Prognosis
Prothrombin time
activated partial thromboplastin time
adult
aged
article
breathing rate
cerebrovascular disease
chronic kidney failure
chronic obstructive lung disease
clinical outcome
communicable disease
comorbidity
controlled study
coronavirus disease 2019
demography
female
hospital discharge
hospitalization
human
hypertension
incidence
Kaplan Meier method
laboratory test
major clinical study
male
middle aged
platelet count
survivor
vital sign
D dimer
fibrin degradation product
LA  - English
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 4370-4379
ST  - Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients
T2  - World Journal of Clinical Cases
TI  - Prolonged prothrombin time at admission predicts poor clinical outcome in COVID-19 patients
UR  - https://f6publishing.blob.core.windows.net/ac490615-79d5-45c7-9ca1-6b111461903f/WJCC-8-4370.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998319
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i19.4370&issn=2307-8960&isbn=&volume=8&issue=19&spage=4370&pages=4370-4379&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Prolonged+prothrombin+time+at+admission+predicts+poor+clinical+outcome+in+COVID-19+patients&aulast=Wang&pid=%3Cauthor%3EWang+L.%2CHe+W.-B.%2CYu+X.-M.%2CHu+D.-L.%2CJiang+H.%3C%2Fauthor%3E&%3CAN%3E632998319%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 8
ID  - 7782820
ER  - 

TY  - JOUR
AB  - The Novel Coronavirus (COVID-19), which broke out in Wuhan, China in December 2019, attracted worldwide attention. With a long incubation period and strong infectiousness, COVID-19 poses a great threat to the life and health worldwide with high incidence, high pathogenicity and low sensitivity to antibiotics. At present, there are less kinds of antiviral drugs, including rimantadine hydiochloride, acyclovir, interferon, zidovudine, ribavirin, etc., which maybe lead to severe adverse reactions of the nervous system, hematopoietic system, liver and kidney system, as well as side effects such as nausea, vomiting, upper abdominal discomfort and diarrhea. Meanwhile, the development of antiviral drugs requires huge investment and time, the development of effective antiviral drugs and vaccine lags far behind the rapidly developed disease. Traditional Chinese medicine has played an important role against the infection, especially in the fight against severe acute respiratory syndrome, H1N1 influenza, H7N9 flu virus, middle east respiratory syndrome and Ebola virus infection. In this paper, the classification, mechanism, existing problems and the prospect of traditional Chinese medicine in antiviral treatment has been summarized in order to provide certain reference for the research and prescription screening of traditional Chinese medicine anti-COVID-19 drugs. Copyright © 2020, Mediengruppe Oberfranken - Fachverlage GmbH & Co. KG.
AD  - (Wang, Wang, Chen, Shi) Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, Taizhou 225300, China
Q. Wang, Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, No. 86, Jichuan East Road, Taizhou 225300, China. E-mail: wangqin322@126.com L.-W. Chen, Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine, No. 86, Jichuan East Road, Taizhou 225300, China. E-mail: chenlinwei89@126.com
AN  - 2007937792
AU  - Wang, H.
AU  - Wang, Q.
AU  - Chen, J. Y.
AU  - Shi, G. J.
AU  - Chen, L. W.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.12032/TMRIM202004014
DP  - Ovid Technologies
IS  - no pagination
KW  - Antiviral treatment
Mechanism
Prospect
Research status
Traditional Chinese medicine
antiviral therapy
Chinese medicine
Ebola hemorrhagic fever
human
influenza A (H1N1)
investment
Middle East respiratory syndrome
prescription
review
severe acute respiratory syndrome
anti-SARS-CoV-2 agent
vaccine
LA  - English
M3  - Review
N1  - Using Smart Source Parsing
( Date of Publication: 2020
PY  - 2020
SN  - 2521-3415 (electronic)
2521-3415
ST  - Traditional Chinese medicine in antiviral treatment
T2  - TMR Integrative Medicine
TI  - Traditional Chinese medicine in antiviral treatment
UR  - https://www.tmrjournals.com/uploads/soft/200814/22-200Q4123354.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007937792
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12032%2FTMRIM202004014&issn=2521-3415&isbn=&volume=4&issue=&spage=&pages=&date=2020&title=TMR+Integrative+Medicine&atitle=Traditional+Chinese+medicine+in+antiviral+treatment&aulast=Wang&pid=%3Cauthor%3EWang+H.%2CWang+Q.%2CChen+J.-Y.%2CShi+G.-J.%2CChen+L.-W.%3C%2Fauthor%3E&%3CAN%3E2007937792%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 4
ID  - 7782882
ER  - 

TY  - JOUR
AB  - Motor vehicle crashes remain the leading cause of adolescent mortality and injury in the United States. For young drivers, crash risk peaks immediately after licensure and declines during the next two years, making the point of licensure an important safety intervention opportunity. Legislation in Ohio established a unique health-transportation partnership among the State of Ohio, Children's Hospital of Philadelphia, and Diagnostic Driving, Inc., to identify underprepared driver license applicants through a virtual driving assessment system. The system, a computer-based virtual driving test, exposes drivers to common serious crash scenarios to identify critical skill deficits and is delivered in testing centers immediately before the on-road examination. A pilot study of license applicants who completed it showed that the virtual driving assessment system accurately predicted which drivers would fail the on-road examination and provided automated feedback that informed drivers on their skill deficits. At this time, the partnership's work is informing policy changes around integrating the virtual driving assessment system into licensing and driver training with the aim of reducing crashes in the first months of independent driving. The system can be developed to identify deficits in safety-critical skills that lead to crashes in new drivers and to address challenges that the coronavirus disease 2019 pandemic has introduced to driver testing and training.
AD  - Elizabeth A. Walshe is a research scientist at the Center for Injury Research and Prevention at the Children's Hospital of Philadelphia, in Philadelphia, Pennsylvania.
Daniel Romer is the research director in the Annenberg Public Policy Center, University of Pennsylvania, in Philadelphia, Pennsylvania.
Venkatesh Kandadai is the chief executive officer of Diagnostic Driving Inc., in Philadelphia, Pennsylvania.
Flaura K. Winston (winston@email.chop.edu) is a professor of pediatrics at the University of Pennsylvania Perelman School of Medicine, distinguished chair in the Department of Pediatrics, scientific director in the Center for Injury Research and Prevention, and scientific advisor in the Office of Entrepreneurship and Innovation at the Children's Hospital of Philadelphia, and is a member of the National Academy of Medicine.
AN  - 33017232
AU  - Walshe, E. A.
AU  - Romer, D.
AU  - Kandadai, V.
AU  - Winston, F. K.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1377/hlthaff.2020.00802
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Health affairs (Project Hope)
LA  - eng
N1  - 1544-5208
Walshe, Elizabeth A
Romer, Daniel
Kandadai, Venkatesh
Winston, Flaura K
Journal Article
United States
Health Aff (Millwood). 2020 Oct;39(10):1792-1798. doi: 10.1377/hlthaff.2020.00802.
PY  - 2020
SN  - 0278-2715
SP  - 1792-1798
ST  - A Novel Health-Transportation Partnership Paves The Road For Young Driver Safety Through Virtual Assessment
T2  - Health affairs (Project Hope)
TI  - A Novel Health-Transportation Partnership Paves The Road For Young Driver Safety Through Virtual Assessment
VL  - 39
ID  - 7785152
ER  - 

TY  - JOUR
AB  - To diminish the risk of spreading COVID-19 as society exits the lockdowns, several apps have been developed for contact tracing. These apps register which users have been in proximity of each other. If a user is diagnosed with COVID-19, app users who have been recently in proximity to this person are notified. The effectiveness of these apps highly depends on public support. Therefore, this study investigated the factors that influence app use intention, based on an extended unified theory of acceptance and use of technology model. A survey was administered in Belgium (Flanders) to 1,500 participants aged 18 to 64 years old. Structural equation modeling was used to test the relationships among the model's constructs. Our results indicated that 48.70 percent of the respondents wanted to use the app. The model explained 39 percent of the variance in app use intention. The most important predictor was performance expectancy, followed by facilitating conditions and social influence. Effort expectancy was not related to intention. Moreover, individuals' innovativeness was positively related with app use intention, whereas app-related privacy concerns negatively influenced intention. Based on the results, suggestions are made for policy makers and developers.
AD  - Department of Communication Studies, Research Group MIOS, University of Antwerp, Antwerp, Belgium.
Department of Communication Sciences, Research Group IMEC-MICT, Ghent University, Ghent, Belgium.
AN  - 33017171
AU  - Walrave, M.
AU  - Waeterloos, C.
AU  - Ponnet, K.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1089/cyber.2020.0483
DP  - NLM
ET  - 2020/10/06
J2  - Cyberpsychology, behavior and social networking
KW  - Covid-19
Utaut
contact tracing
coronavirus
privacy
proximity tracing
LA  - eng
N1  - 2152-2723
Walrave, Michel
Waeterloos, Cato
Ponnet, Koen
Journal Article
United States
Cyberpsychol Behav Soc Netw. 2020 Oct 5. doi: 10.1089/cyber.2020.0483.
PY  - 2020
SN  - 2152-2715
ST  - Ready or Not for Contact Tracing? Investigating the Adoption Intention of COVID-19 Contact-Tracing Technology Using an Extended Unified Theory of Acceptance and Use of Technology Model
T2  - Cyberpsychology, behavior and social networking
TI  - Ready or Not for Contact Tracing? Investigating the Adoption Intention of COVID-19 Contact-Tracing Technology Using an Extended Unified Theory of Acceptance and Use of Technology Model
ID  - 7785158
ER  - 

TY  - JOUR
AB  - Objective: The first case of a new strain of coronavirus (CoV), usually known as CoV disease (COVID)-19, was recognized in Wuhan city of China, in December 2019. Till today, there are no specific treatments available against COVID. During literature searching, it was observed that drugs such as remdesivir, hydroxychloroquine, and chloroquine as their therapeutic options to stop the progress of COVID-19 infections. In the present study, the molecular docking study was performed to understand the binding pattern of selected drugs. Method(s): Molecular docking methods were carried out using molecular virtual Docker software using COVID-19 protease (PDB ID 6LU7), and interactions of these three drugs were visualized. Conclusion(s): All three drugs have shown binding interactions with an active site. We assume that these inhibitory activities helped us to identify the possible drug mechanism and further designing of new molecules or investigate the potential use of other available drugs. Copyright © 2020 The Authors.
AD  - (Wadhwa) Department of Pharmaceutical Chemistry, Lovely School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India
P. Wadhwa, Department of Pharmaceutical Chemistry, Lovely School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India. E-mail: pankaj.23400@lpu.co.in
AN  - 2007704713
AU  - Wadhwa, P.
C1  - 10/6/2020
DA  - September
DB  - Embase
DO  - http://dx.doi.org/10.22159/ajpcr.2020.v13i9.38501
DP  - Ovid Technologies
IS  - 9
KW  - Chloroquine
Coronavirus
Hydroxychloroquine
Molecular docking
Protease
Remdesivir
article
case report
China
clinical article
coronavirus disease 2019
drug mechanism
drug therapy
human
information retrieval
software
endogenous compound
proteinase
LA  - English
PY  - 2020
SN  - 0974-2441
2455-3891
SP  - 37-39
ST  - MOLECULAR DOCKING STUDY of NOVEL COVID-19 PROTEASE with CURRENT CLINICAL MANAGEMENT AGENTS
T2  - Asian Journal of Pharmaceutical and Clinical Research
TI  - MOLECULAR DOCKING STUDY of NOVEL COVID-19 PROTEASE with CURRENT CLINICAL MANAGEMENT AGENTS
UR  - https://innovareacademics.in/journals/index.php/ajpcr/article/view/38501/23452
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007704713
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.22159%2Fajpcr.2020.v13i9.38501&issn=0974-2441&isbn=&volume=13&issue=9&spage=37&pages=37-39&date=2020&title=Asian+Journal+of+Pharmaceutical+and+Clinical+Research&atitle=MOLECULAR+DOCKING+STUDY+of+NOVEL+COVID-19+PROTEASE+with+CURRENT+CLINICAL+MANAGEMENT+AGENTS&aulast=Wadhwa&pid=%3Cauthor%3EWadhwa+P.%3C%2Fauthor%3E&%3CAN%3E2007704713%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 13
ID  - 7782857
ER  - 

TY  - JOUR
AB  - The exponential increase of the older segment of the population is coinciding with the growing challenges of a digital society in different socio-cultural contexts. This exploratory study aims to analyze older adult perspectives of how smart technology influenced their meaning in life during the Covid-19 Public Health Emergency period, using qualitative research at a cross-national level. Three hundred and fifty-one community-dwelling older participants aged 65-87 years were included in the study. Participants were Italian, Mexican, Portuguese and Spanish. All the narratives went through a process of content analysis. Findings of content analysis produced six themes: Meaningful relations, rewarding activities, spirituality, health and safety-related support, self-growth, and physical activity. Smart technology was important in promoting significant relations for Mexican older adults (71.3%), rewarding activities for Portuguese older adults (57.1%), spirituality for Spanish older participants (71.6%), and physical activity for Italian older adults (29.5%). This study indicated that smart technology during the Health Emergency period was important for the meaning in life of older populations, mostly by facilitating meaningful relations, rewarding activities and spirituality. Future interventions with older adults during pandemic periods should consider the diversity of themes associated with increasing older adult well-being, from a cross-cultural perspective.
AD  - William James Research Center, ISPA - Instituto Universit֙rio, Lisbon, Portugal.
Health Sciences Division, Universidad de Guadalajara CUTONALA, Guadalajara, Mexico.
Public Health Department, Universidad de Guadalajara CUCS, Guadalajara, Mexico.
ISPA - Instituto Universit֙rio, Lisbon, Portugal.
Departamento de Educaci�Qn, Universidad Antonio de Nebrija, Madrid, Spain.
Faculty of Nursing, University of Alberta, Edmonton, Canada.
AN  - 33016790
AU  - von Humboldt, S.
AU  - Mendoza-Ruvalcaba, N. M.
AU  - Arias-Merino, E. D.
AU  - Costa, A.
AU  - Cabras, E.
AU  - Low, G.
AU  - Leal, I.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/09540261.2020.1810643
DP  - NLM
ET  - 2020/10/06
J2  - International review of psychiatry (Abingdon, England)
KW  - Cross-cultural
meaning in life
older adults
positive psychology
smart technology
LA  - eng
N1  - 1369-1627
von Humboldt, Sofia
Orcid: 0000-0001-9664-6735
Mendoza-Ruvalcaba, Neyda Ma
Arias-Merino, Elva Dolores
Costa, Andrea
Cabras, Emilia
Low, Gail
Leal, Isabel
Journal Article
England
Int Rev Psychiatry. 2020 Oct 5:1-10. doi: 10.1080/09540261.2020.1810643.
PY  - 2020
SN  - 0954-0261
SP  - 1-10
ST  - Smart technology and the meaning in life of older adults during the Covid-19 public health emergency period: a cross-cultural qualitative study
T2  - International review of psychiatry (Abingdon, England)
TI  - Smart technology and the meaning in life of older adults during the Covid-19 public health emergency period: a cross-cultural qualitative study
ID  - 7785178
ER  - 

TY  - JOUR
AD  - Department of Psychiatry, New York-Presbyterian/Columbia University Irving Medical Center, and New York State Psychiatric Institute, New York.
AN  - 33019860
AU  - Villarin, J. M.
AU  - Gao, Y. N.
AU  - McCann, R. F.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1176/appi.ps.72304
DP  - NLM
ET  - 2020/10/07
J2  - Psychiatric services (Washington, D.C.)
KW  - Covid-19
Emergency care
Intensive care
Psychiatric resident
Rapid response
LA  - eng
N1  - 1557-9700
Villarin, Joseph M
Gao, Y Nina
McCann, Ruth F
Journal Article
United States
Psychiatr Serv. 2020 Oct 6:appips72304. doi: 10.1176/appi.ps.72304.
PY  - 2020
SN  - 1075-2730
SP  - appips72304
ST  - Frontline Redeployment of Psychiatry Residents During the COVID-19 Pandemic
T2  - Psychiatric services (Washington, DC)
TI  - Frontline Redeployment of Psychiatry Residents During the COVID-19 Pandemic
ID  - 7785080
ER  - 

TY  - JOUR
AU  - Venter, F.
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 7
KW  - Coronavirus Infections
Dissent and Disputes
Freedom
Pandemics
Pneumonia, Viral
Politics
Public Policy
Betacoronavirus
Government
Humans
South Africa
Speech
LA  - en
PY  - 2020
SP  - 555-560
ST  - Statement of support for Professor Glenda Gray and the principle of academic freedom of speech
T2  - S Afr Med J
TI  - Statement of support for Professor Glenda Gray and the principle of academic freedom of speech
UR  - https://dx.doi.org/10.7196/SAMJ.2020.v110i7.14964
VL  - 110
ID  - 7788793
ER  - 

TY  - JOUR
AB  - Background: The coronavirus disease 2019 (COVID-19) pandemic is straining health care worldwide with 31 million confirmed cases. Currently, 1 in every 100 U.S. residents and 245,000 in New York City are confirmed positive. The Bronx, with high-risk comorbidities, due in part to socioeconomic factors, has seen disproportionately higher rates of COVID-19-related complications. Poor health care access is exacerbated as in-person visits now pose viral transmission risk. There has been limited discourse regarding widespread disparities underlying transitions to telemedicine. Methods: We review perspectives in recent literature on telemedicine and its potential within neurology. Results: While telemedicine has reduced strain on in-person visits, preliminary reflections highlight implementation successes and challenges. Conclusions: To provide effective care beyond this crisis, fundamental changes in training, technological accessibility, and health care policy are needed. We propose open access to telehealth training, screening of patient's potential technological inequities and socioeconomic insecurities, and advocacy to secure broad long-term access to telehealth care.
AD  - Albert Einstein College of Medicine, Bronx, New York, USA.
Princeton University, Princeton, New Jersey, USA.
Saul R. Korey Department of Neurology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
Department of Neurology, Montefiore Medical Center, Bronx, New York, USA.
AN  - 33017270
AU  - Vazquez, J.
AU  - Islam, T.
AU  - Gursky, J.
AU  - Beller, J.
AU  - Correa, D. J.
C1  - 10/6/2020
DA  - Sep 30
DB  - PubMed
DO  - 10.1089/tmj.2020.0371
DP  - NLM
ET  - 2020/10/06
J2  - Telemedicine journal and e-health : the official journal of the American Telemedicine Association
KW  - diversity
equity
health disparities
health policy
inclusion
medical ethics
structural and social determinants of health
telehealth
telemedicine
LA  - eng
N1  - 1556-3669
Vazquez, Juan
Islam, Tanzina
Gursky, Jonathan
Beller, Jennifer
Correa, Daniel Jose
Journal Article
United States
Telemed J E Health. 2020 Sep 30. doi: 10.1089/tmj.2020.0371.
PY  - 2020
SN  - 1530-5627
ST  - Access to Care Matters: Remote Health Care Needs During COVID-19
T2  - Telemedicine journal and e-health : official journal of American Telemedicine Association
TI  - Access to Care Matters: Remote Health Care Needs During COVID-19
ID  - 7785146
ER  - 

TY  - JOUR
AD  - Toronto, Ont.
AN  - 33020127
AU  - Varner, C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1503/cmaj.1095898
DP  - NLM
ET  - 2020/10/07
IS  - 40
J2  - CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne
LA  - eng
N1  - 1488-2329
Varner, Catherine
Journal Article
Canada
CMAJ. 2020 Oct 5;192(40):E1171-E1172. doi: 10.1503/cmaj.1095898.
PY  - 2020
SN  - 0820-3946
SP  - E1171-e1172
ST  - Hospitals rolling out the "welcome mat" to ease COVID-19 fears
T2  - Canadian Medical Association journal = journal de l'Association medicale canadienne
TI  - Hospitals rolling out the "welcome mat" to ease COVID-19 fears
VL  - 192
ID  - 7785049
ER  - 

TY  - JOUR
AD  - (Vargas) Vicedecano Nacional del Colegio Medico del Peru, Lima, Peru (Vargas) Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru (Vargas) Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima, Peru (Vargas) Medico infectologo, Tropicalista, Dermatologo
C.M. Vargas, Vicedecano Nacional del Colegio Medico del Peru, Lima, Peru. E-mail: ciro.maguina@upch.pe
AN  - 2007384817
AU  - Vargas, C. M.
C1  - 10/6/2020
DA  - 31 Mar
DB  - Embase
DO  - http://dx.doi.org/10.35663/amp.2020.371.929
DP  - Ovid Technologies
IS  - 1
KW  - coronavirus disease 2019
editorial
human
Peru
public health
LA  - Spanish
M3  - Editorial
PY  - 2020
SN  - 1018-8800
1728-5917
SP  - 8-10
ST  - Reflections on COVID-19 infection, Colegio Medico del Peru and the Public Health. [Spanish]
T2  - Acta Medica Peruana
TI  - Reflections on COVID-19 infection, Colegio Medico del Peru and the Public Health. [Spanish]
TT  - Reflexiones sobre el COVID-19, el Colegio Medico del Peru y la Salud Publica.
UR  - https://amp.cmp.org.pe/index.php/AMP/article/view/929/405
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007384817
VL  - 37
ID  - 7782947
ER  - 

TY  - JOUR
AB  - OBJECTIVES: COVID-19 predisposes patients to thrombotic disease. The aim of this guidance document is to provide Belgian health-care workers with recommendations on anticoagulation management in COVID-19 positive patients. METHODS: These recommendations were based on current knowledge and a limited level of evidence. RESULTS: We formulated recommendations for the prophylaxis and treatment of COVID-related venous thromboembolism in ambulatory and hospitalised patients, as well as recommendations for the use of antithrombotic drugs in patients with prior indication for anticoagulation who develop COVID-19. CONCLUSIONS: These recommendations represent an easy-to-use practical guidance that can be implemented in every Belgian hospital and be used by primary care physicians and gynaecologists. Of note, they are likely to evolve with increased knowledge of the disease and availability of data from ongoing clinical trials.
AD  - Department of Cardiovascular Sciences, University of Leuven , Leuven, Belgium.
Department of Haematology, Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel , Brussels, Belgium.
Department of Laboratory Haematology, CHU University Hospital of Li؈ge , Li؈ge, Belgium.
Department of Haematology, Antwerp University Hospital , Antwerp, Belgium.
Department of Haematology, Cliniques Universitaires St-Luc , Brussels, Belgium.
Department of Laboratory Medicine, Thrombosis-haemostasis and Transfusion Unit, CHR Citadelle , Li؈ge, Belgium.
Department of Vascular Diseases, Erasme University Hospital, Université Libre de Bruxelles , Brussels, Belgium.
Department of Cardiac Intensive Care, Ghent University Hospital , Ghent, Belgium.
Department of Cardiology, CHU University Hospital of Li؈ge , Li؈ge, Belgium.
Vlaamse Vereniging voor Obstetrie en Gynaecologie, Universitair Ziekenhuis Gent , Ghent, Belgium.
Groupement des Gynécologues Obstétriciens de Langue Française de Belgique, CHU University Hospital of Li؈ge.
Laboratory of Cardiology, GIGA Institute, University of Li؈ge , Li؈ge, Belgium.
AN  - 33012274
AU  - Vanassche, T.
AU  - Orlando, C.
AU  - Vandenbosch, K.
AU  - Gadisseur, A.
AU  - Hermans, C.
AU  - Jochmans, K.
AU  - Minon, J. M.
AU  - Motte, S.
AU  - Peperstraete, H.
AU  - Péters, P.
AU  - Sprynger, M.
AU  - Lancellotti, P.
AU  - Dehaene, I.
AU  - Emonts, P.
AU  - Vandenbriele, C.
AU  - Verhamme, P.
AU  - Oury, C.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1080/17843286.2020.1829252
DP  - NLM
ET  - 2020/10/06
J2  - Acta clinica Belgica
KW  - Covid-19
Practice guideline
primary health care
LA  - eng
N1  - 2295-3337
Vanassche, Thomas
Orcid: 0000-0002-7404-8918
Orlando, Christelle
Orcid: 0000-0003-2163-8778
Vandenbosch, Kristel
Gadisseur, Alain
Hermans, Cédric
Jochmans, Kristin
Minon, Jean-Marc
Motte, Serge
Peperstraete, Harlinde
Orcid: 0000-0001-5435-1752
Péters, Pierre
Sprynger, Muriel
Orcid: 0000-0003-4358-0183
Lancellotti, Patrizio
Dehaene, Isabelle
Orcid: 0000-0002-4826-6946
Emonts, Patrick
Vandenbriele, Christophe
Verhamme, Peter
Oury, Cécile
Orcid: 0000-0002-7561-0132
Journal Article
England
Acta Clin Belg. 2020 Oct 3:1-6. doi: 10.1080/17843286.2020.1829252.
PY  - 2020
SN  - 1784-3286
SP  - 1-6
ST  - Belgian clinical guidance on anticoagulation management in hospitalised and ambulatory patients with COVID-19
T2  - Acta clinica Belgica
TI  - Belgian clinical guidance on anticoagulation management in hospitalised and ambulatory patients with COVID-19
ID  - 7785607
ER  - 

TY  - JOUR
AD  - Nuffield Department of Primary Care Health Sciences, Oxford University.
TB Proof, South Africa.
AN  - 33008828
AU  - van der Westhuizen, H. M.
AU  - Kotze, K.
AU  - Tonkin-Crine, S.
AU  - Gobat, N.
AU  - Greenhalgh, T.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1136/bmj.m3799
DP  - NLM
ET  - 2020/10/04
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
van der Westhuizen, Helene-Mari
Kotze, Koot
Tonkin-Crine, Sarah
Gobat, Nina
Greenhalgh, Trisha
Letter
England
BMJ. 2020 Oct 2;371:m3799. doi: 10.1136/bmj.m3799.
PY  - 2020
SN  - 0959-8138
SP  - m3799
ST  - Authors' reply to Kolstoe and Hanna and colleagues
T2  - BMJ (Clinical research ed)
TI  - Authors' reply to Kolstoe and Hanna and colleagues
VL  - 371
ID  - 7788913
ER  - 

TY  - JOUR
AD  - Ospedale G.B. Morgagni �?L. Pierantoni, AUSL della Romagna, Forlì, Italy
AU  - Valletta, E.
AU  - Fornaro, M.
C1  - 10/6/2020
DB  - Scopus
IS  - 5
J2  - Quad. ACP
LA  - Italian
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Valletta, E.; Ospedale G.B. Morgagni �?L. Pierantoni, AUSL della RomagnaItaly; email: enrico.valletta@auslromagna.it
References: Duncan, CJ, Scott, S., What caused the Black Death? (2005) Postgrad Med J, 81 (955), pp. 315-320. , May; Ahmed, F, Ahmed, N, Pissarides, C, Stiglitz, J., Why inequality could spread Covid-19 (2020) Lancet Public Health, 5 (5), p. e240. , May; Niedzwiedz, CL, O’Donnell, CA, Jani, BD, Ethnic and socioeconomic differences in SARS-CoV-2 infection: prospective cohort study using UK Biobank (2020) BMC Med, 18 (1), p. 160. , May 29; Myers, EM., (2020) Compounding Health Risks and Increased Vulnerability to SARS-CoV-2 for Racial and Ethnic Minorities and Low Socioeconomic Status Individuals in the United States, , Preprints; Butcher, B, Massey, J., Why are more people from BAME backgrounds dying from corona-virus?, , www.bbc.com, 19 June 2020; De Noronha, N., Why are more black and minority ethnic people dying from Covid-19 in hospital? Blog, Covid-19, Health & Care, , https://raceequalityfoundation.org.uk/; Singh, I, Chand, K, Singh, A, Kandadi, KR., Time for a culture change: understanding and reducing risk, morbidity and mortality from COVID-19 in those of black and minority ethnicity (2020) Br J Hosp Med (Lond), 81 (5), pp. 1-4. , May 2; O’Dowd, A., Covid-19: People in most de-prived areas of England and Wales twice as likely to die (2020) BMJ, 369, p. m2389. , Jun 12; Patel, P, Hiam, L, Sowemimo, A, Ethnicity and covid-19 (2020) BMJ, 369, p. m2282. , Jun 11; Peate, I., Why are more BAME people dying from COVID-19? (2020) Br J Nurs, 29 (10), p. 545. , May 28; Dodds, C, Fakoya, I., Covid-19: ensuring equality of access to testing for ethnic minori-ties (2020) BMJ, 369, p. m2122. , May 29; Phelan, JC, Link, BG, Tehranifar, P., Social conditions as fundamental causes of health inequalities: theory, evidence, and policy im-plications (2010) J Health Soc Behav, 51, pp. S28-S40. , Sup-pl; Yaya, S, Yeboah, H, Charles, CH, Ethnic and racial disparities in COVID-19-re-lated deaths: counting the trees, hiding the for-est (2020) BMJ Glob Health, 5 (6), p. e002913. , Jun; The color of coronavirus: Covid-19 deaths by race and ethnicity in the U.S. 2020 www.apmre-searchlab.org, APM Research Lab Staff. June 24; Curtice, K, Choo, E., Indigenous popula-tions: left behind in the COVID-19 response (2020) Lancet, 395 (10239), p. 1753. , Jun 6; Waitzberg, R, Davidovitch, N, Leibner, G, Israel’s response to the COVID-19 pandemic: tailoring measures for vulnerable cultural minority populations (2020) Int J Equity Health, 19 (1), p. 71. , May 19; Saban, M, Shachar, T, Miron, O, Wilf-Miron, R., Effect of socioeconomic and ethnic characteristics on Covid-19 infection: The case of the Ultra-Orthodox and the Arab commu-nities in Israel (2020) Research Square, , https://doi.org/10.21203/rs.3.rs-32401/v1; Kearney, L, Lennane, S, Woodman, E, At least 23 nationalities among NHS staff killed by covid (2020) Health Serv J, 19. , www.hsj.co.uk, May; Papineni, P, Harrison, T, Mutuyima-na, J., Ethnicity and covid-19: analysis must be inclusive and transparent (2020) BMJ, 369, p. m2166. , Jun 1; Kar, P., Covid-19 and ethnicity-why are all our angels white? (2020) BMJ, 369, p. m1804. , May 5; Rimmer, A., Covid-19: Two thirds of health-care workers who have died were from ethnic minorities (2020) BMJ, 369, p. m1621. , Apr 23; Characteristics of Health Care Personnel with COVID-19-United States, February 12-April 9, 2020 (2020) MMWR Morb Mortal Wkly Rep, 69 (15), pp. 477-481. , CDC COVID-19 Response Team. Apr 17; He, J, He, L, Zhou, W, Discrimina-tion and Social Exclusion in the Outbreak of COVID-19 (2020) Int J Environ Res Public Health, 17 (8), p. 2933. , Apr 23; Franzini, M., (2020) Il Covid-19 e le disugua-glianze economiche, , www.que-stionegiustizia.it, Aprile 8; After COVID-19, a future for the world’s children? (2020) Lancet, 396 (10247), pp. 298-300. , WHO–UNICEF Lancet Commission-ers. Aug 1
PY  - 2020
SN  - 20391374 (ISSN)
SP  - 219-221
ST  - Per il SARS-CoV-2 non siamo tutti uguali
T2  - Quaderni ACP
TI  - Per il SARS-CoV-2 non siamo tutti uguali
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091717892&partnerID=40&md5=6ed8c96c98cb0994fff348b1f093ab19
VL  - 27
ID  - 7783301
ER  - 

TY  - JOUR
AB  - Epithelioid sarcoma (ES) is a rare malignant mesenchymal neoplasm that accounts for less than one percent of all soft-tissue sarcomas. Only two cases of ES involving the adrenal gland were found after a literature review. We report a case of an 82-year-old female initially presenting with right flank pain who was subsequently found to have an incidental left adrenal mass on CT imaging. After appropriate diagnostic workup, the patient underwent surgical resection. A diagnosis of ES was made from the histopathological analysis. The characteristic findings of ES are epithelioid cells with rhabdoid morphology and moderate eosinophilic cytoplasm. Immunohistochemical findings are significant for positive staining for epithelial markers, cytokeratins, vimentin, and CD34, and loss of INI-1 stain. Due to the aggressive nature and limited data of ESs, the standard treatment continues to remain wide surgical excision.
AD  - USF Health Morsani College of Medicine, 560 Channelside Drive, Tampa, FL 33602, USA ; USF Health Morsani College of Medicine, 560 Channelside Drive, Tampa, FL 33602, USA
AN  - 2448261397
AU  - Valeria Pereira, Martinez
AU  - Nicholson, Marilin
AU  - Patel, Trushar
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/8864218
DP  - ProQuest Central
KW  - Medical Sciences--Urology And Nephrology
Cytoplasm
Histopathology
Medical prognosis
Metastasis
Laparoscopy
Adrenal glands
Metabolism
Pathology
Surveillance
Tumors
Sarcoma
Morphology
COVID-19
Stains & staining
LA  - English
N1  - Copyright - Copyright © 2020 Valeria Pereira Martinez et al. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
PY  - 2020
SN  - 2090696X
ST  - Abnormal Adrenal Mass Presents as Proximal Epithelioid Sarcoma
T2  - Case Reports in Urology
TI  - Abnormal Adrenal Mass Presents as Proximal Epithelioid Sarcoma
UR  - https://www.proquest.com/docview/2448261397?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Abnormal+Adrenal+Mass+Presents+as+Proximal+Epithelioid+Sarcoma&title=Case+Reports+in+Urology&issn=2090696X&date=2020-01-01&volume=2020&issue=&spage=&au=Valeria+Pereira+Martinez%3BNicholson%2C+Marilin%3BPatel%2C+Trushar&isbn=&jtitle=Case+Reports+in+Urology&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F8864218
VL  - 2020
ID  - 7784941
ER  - 

TY  - JOUR
AB  - BACKGROUND: Despite reported higher rates and worse outcomes due to Covid-19 in certain racial and ethnic groups, much remains unknown. We explored the association between Hispanic ethnicity and outcomes in Covid-19 patients in Long Island, New York. METHODS: We conducted a retrospective cohort study of 2,039 Hispanic and non-Hispanic Caucasian patients testing positive for SARS-CoV-2 between March 7 to May 23, 2020 at a large suburban academic tertiary-care hospital near New York City. We explored the association of ethnicity with need for intensive care (ICU), invasive mechanical ventilation (IMV), and mortality. RESULTS: Of all patients, 1,079 (53%) were non-Hispanic Caucasians and 960 (47%) were Hispanic. Hispanic patients presented in higher numbers than expected for our catchment area. Compared with Caucasians, Hispanics were younger (45 vs 59), had fewer comorbidities (66% with no comorbidities vs 40%), were less likely to have commercial insurance (35% vs 59%), or come from a nursing home (2% vs 10%). In univariate comparisons, Hispanics were less likely to be admitted (37% vs 59%) or to die (3% vs 10%). Age, shortness of breath, congestive heart failure (CHF), coronary artery disease (CAD), hypoxemia, and presentation from nursing homes were associated with admission. Male sex and hypoxemia were associated with ICU admission. Male sex, chronic obstructive pulmonary disease, and hypoxemia were associated with IMV. Male sex, CHF, CAD, and hypoxemia were associated with mortality. After adjusting for other factors Hispanics were less likely to be admitted (OR 0.62, 95% I 0.52-0.92) but Hispanic ethnicity was not associated with ICU admission, IMV or mortality. CONCLUSIONS: Hispanics presented at higher rates than average for our population but outcomes among Hispanic patients with Covid-19 were similar to Caucasian patients.
AD  - Dept of Emergency Medicine, Stony Brook University Hospital.
Dept of Medicine, Stony Brook University Hospital.
AN  - 33015939
AU  - Valenzuela, R. G.
AU  - Michelen, Y.
AU  - Bracey, A.
AU  - Cruz, P.
AU  - Fombonne, B.
AU  - Fries, B. C.
AU  - Mallon, W. K.
AU  - Fernandes, R.
AU  - Thode, H. C.
AU  - Singer, A. J.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/acem.14146
DP  - NLM
ET  - 2020/10/06
J2  - Academic emergency medicine : official journal of the Society for Academic Emergency Medicine
KW  - Covid-19
Ethnicity
Hispanics
Race
SARS-CoV-2
coronavirus
health disparities
health equity
LA  - eng
N1  - 1553-2712
Valenzuela, Rolando G
Orcid: 0000-0001-8006-217x
Michelen, Yamil
Bracey, Alexander
Orcid: 0000-0003-0731-9527
Cruz, Priscilla
Fombonne, Benjamin
Fries, Bettina C
Mallon, William K
Fernandes, Rafael
Thode, Henry C
Singer, Adam J
Journal Article
United States
Acad Emerg Med. 2020 Oct 5. doi: 10.1111/acem.14146.
PY  - 2020
SN  - 1069-6563
ST  - Outcomes in Hispanics with Covid-19 are similar to Caucasian patients in Suburban New York
T2  - Academic emergency medicine : official journal of Society for Academic Emergency Medicine
TI  - Outcomes in Hispanics with Covid-19 are similar to Caucasian patients in Suburban New York
ID  - 7785233
ER  - 

TY  - JOUR
AD  - 1 Által֙nos Orvostudom֙nyi kar, Csal֙dorvosi Tanszék, Semmelweis Egyetem, Budapest.
2 Egészségtudom֙nyok Doktori Iskola, Debreceni Egyetem, Debrecen.
AN  - 33011705
AU  - Vajer, P.
AU  - Csenteri, O.
AU  - Szab�Q, J.
AU  - Tam֙s, F.
AU  - Kalabay, L.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1556/650.2020.31954
DP  - NLM
ET  - 2020/10/05
IS  - 40
J2  - Orvosi hetilap
KW  - *covid-19
*covid�?9
*family physician
*h֙ziorvos
*teleconsultation
*t֙vkonzult֙ci�Q
LA  - hun
N1  - 1788-6120
Vajer, Péter
Csenteri, Orsolya
Szab�Q, J֙nos
Tam֙s, Ferenc
Kalabay, L֙szl�Q
Journal Article
Hungary
Orv Hetil. 2020 Oct 4;161(40):1699-1705. doi: 10.1556/650.2020.31954.
OP  - H֙ziorvosl֙s a COVID-19-j֙rv֙ny idején.
PY  - 2020
SN  - 0030-6002
SP  - 1699-1705
ST  - [Family medicine during COVID-19 pandemic]
T2  - Orvosi hetilap
TI  - [Family medicine during COVID-19 pandemic]
VL  - 161
ID  - 7785662
ER  - 

TY  - JOUR
AB  - Chemosensitive dysfunctions are now considered as frequent and early symptoms of coronavirus disease 2019 (COVID-19). In the last few weeks, researchers' greatest efforts have been focusing mainly on the analysis of olfactory disorders, neglecting taste dysfunctions. According to our psychophysical evaluations, it can be inferred that the pathogenesis of taste disorders in COVID-19 patients is largely smell-independent. Moreover, isolated gustatory disorders are highly specific of SARS-CoV-2 infection. For these reasons, it is essential that gustatory dysfunctions, like olfactory disorders, are included in the COVID-19 guidelines.
AD  - Maxillofacial Surgery Operative Unit, University Hospital of Sassari, Viale San Pietro 43/B, 07100 Sassari, Italy.
COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Mons, Belgium.
Department of Human and Experimental Oncology, Faculty of Medicine UMONS Research Institute for Health Sciences and Technology, University of Mons (UMons), Mons, Belgium. GRID: grid.8364.9. ISNI: 0000 0001 2184 581X
Maxillofacial Surgery Unit, University Hospital of Naples "Federico II", Via Pansini 5, 80131 Naples, Italy. GRID: grid.4691.a. ISNI: 0000 0001 0790 385X
Otolaryngology Operative Unit, Department of Medicine, Surgery and Dentistry, "Scuola Medica Salernitana", University of Salerno, 84081 Baronissi, Salerno, Italy. GRID: grid.11780.3f. ISNI: 0000 0004 1937 0335
AN  - 33014753
AU  - Vaira, L. A.
AU  - Lechien, J. R.
AU  - Salzano, G.
AU  - Salzano, F. A.
AU  - Maglitto, F.
AU  - Saussez, S.
AU  - De Riu, G.
C1  - 10/6/2020
C2  - PMC7524863
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s12070-020-02182-4
DP  - NLM
ET  - 2020/10/06
J2  - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
KW  - Ageusia
Anosmia
Covid-19
Chemosensitive dysfunction
Coronavirus
Gustatory dysfunction
Olfactory dysfunction
SARS-CoV-2
Taste
LA  - eng
N1  - 0973-7707
Vaira, Luigi Angelo
Orcid: 0000-0002-7789-145x
Lechien, Jerome R
Salzano, Giovanni
Salzano, Francesco Antonio
Maglitto, Fabio
Saussez, Sven
De Riu, Giacomo
Journal Article
Indian J Otolaryngol Head Neck Surg. 2020 Sep 30:1-3. doi: 10.1007/s12070-020-02182-4.
PY  - 2020
SN  - 2231-3796 (Print)
2231-3796
SP  - 1-3
ST  - Gustatory Dysfunction: A Highly Specific and Smell-Independent Symptom of COVID-19
T2  - Indian journal of otolaryngology and head and neck surgery : official publication of Association of Otolaryngologists of India
TI  - Gustatory Dysfunction: A Highly Specific and Smell-Independent Symptom of COVID-19
ID  - 7785365
ER  - 

TY  - JOUR
AB  - Aim We investigated personal protective equipment (PPE) use and its shortage, training, and adverse events among healthcare workers (HCWs) in the intensive care unit (ICU) during the coronavirus disease (COVID-19) pandemic in Japan and compared the results with an international survey that used the same methodology Methods This web-based survey was conducted from April 14 to May 6, 2020, in Japan and included HCWs directly involved in ICU management of COVID-19 patients A survey invitation was emailed using the Japanese Society of Intensive Care Medicine?s mailing list Results We analyzed 460 valid responses from among 976 responses The N95/FFP2 mask (77%) was most frequently used than in the international study, although half of our respondents reported reuse of single-use N95/FFP2 masks The median duration (1 hour) of uninterrupted PPE use per shift was less than that in the international study The commonest PPE-related adverse event was experiencing intense heat (75%) Logistic regression analysis revealed that being a nurse was independently associated with experiencing intense heat Conclusion PPE shortage and frequent mask reuse were prevalent during the COVID-19 pandemic in Japan Intense heat is the most significant symptom, especially for nurses, even with short-duration PPE use Strategies to protect HCWs from dehydration and intense heat stroke are needed
AU  - Unoki, Takeshi
AU  - Tamoto, Mitsuhiro
AU  - Ouchi, Akira
AU  - Sakuramoto, Hideaki
AU  - Nakayama, Asami
AU  - Katayama, Yukiko
AU  - Miyazaki, Satoko
AU  - Yamada, Toru
AU  - Fujitani, Shigeki
AU  - Nishida, Osamu
AU  - Tabah, Alexis
AU  - Ppe-Safe in Japan Project, International Exchange Committee the Japan Society of Intensive Care Medicine
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Personal Protective Equipment Use by Healthcare Workers in Intensive Care Unit During the COVID-19 Pandemic in Japan: Comparative Analysis With the PPE-SAFE Survey
T2  - Acute Medicine & Surgery
TI  - Personal Protective Equipment Use by Healthcare Workers in Intensive Care Unit During the COVID-19 Pandemic in Japan: Comparative Analysis With the PPE-SAFE Survey
UR  - https://doi.org/10.1002/ams2.584
ID  - 7788135
ER  - 

TY  - GEN
AN  - NCT04577378
AU  - University, Kafrelsheikh
C1  - 10/6/2020
DA  - October 20
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19
N1  - No Results Available
Drug: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid) plus Aerosolized Itraconazole|Drug: Drug: Isotretinoin(Aerosolized 13 cis retinoic acid)
lung injury score|Absolute lymphocyte counts|Serum levels of CRP, ESR ,IL-1,IL-6,TNF and Type I interferons|All cause mortality rate|Serum level of viral RNA|Ventilation free days|ICU free days
All
Phase 2
45
Other
Allocation: Randomized|Intervention Model: Sequential Assignment|Masking: Single (Participant)|Primary Purpose: Treatment
Isotretinoin
November 20, 2020
PB  - https://ClinicalTrials.gov/show/NCT04577378
PY  - 2020
ST  - Isotretinoin
T2  - ClinicalTrials
TI  - Efficacy and Safety of Drug Combination Therapy of Isotretinoin and Some Antifungal Drugs as A Potential Aerosol Therapy for COVID-19 : An Innovative Therapeutic Approach COVID-19
UR  - https://ClinicalTrials.gov/show/NCT04577378
ID  - 7788855
ER  - 

TY  - JOUR
AB  - Currently clinicians all around the world are experiencing a pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical presentation of this pathology includes fever, dry cough, fatigue and acute respiratory distress syndrome that can lead to death infected patients. Current studies on coronavirus disease 2019 (COVID-19) continue to highlight the urgent need for an effective therapy. Numerous therapeutic strategies have been used until now but, to date, there is no specific effective treatment for SARS-CoV-2 infection. Elevated inflammatory cytokines have been reported in patients with COVID-19. Evidence suggests that elevated cytokine levels, reflecting a hyperinflammatory response secondary to SARS-CoV-2 infection, are responsible for multi-organ damage in patients with COVID-19. For these reason, numerous randomized clinical trials are currently underway to explore the effectiveness of biopharmaceutical drugs, such as, interleukin-1 blockers, interleukin-6 inhibitors, Janus kinase inhibitors, in COVID-19. The aim of the present paper is to briefly summarize the pathogenetic rationale and the state of the art of therapeutic strategy blocking hyperinflammation. Copyright © The Author(s) 2020.
AD  - (Ucciferri, Vecchiet, Falasca) Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University 'G. d'Annunzio' Chieti-Pescara, Chieti 66100, Italy (Ucciferri) Department of Medicine and Health Sciences, University of Molise, Campobasso 66100, Italy
K. Falasca, Clinic of Infectious Diseases, Department of Medicine and Science of Aging, University 'G. d'Annunzio' Chieti-Pescara, Via dei Vestini, Chieti 66100, Italy. E-mail: k.falasca@unich.it
AN  - 632998274
AU  - Ucciferri, C.
AU  - Vecchiet, J.
AU  - Falasca, K.
C1  - 10/6/2020
DA  - 01 Oct
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i19.4280
DP  - Ovid Technologies
IS  - 19
KW  - Anakinra
Baricitinib
Canakinumab
Clazakizumab
Ruxolitinib
Sarilumab
Siltuximab
Tocilizumab
Tofacitinib
adult
controlled study
coronavirus disease 2019
drug therapy
gene expression
human
hyperinflammation
organ injury
protein expression
randomized controlled trial (topic)
review
endogenous compound
interleukin 1
interleukin 6
LA  - English
M3  - Review
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 4280-4285
ST  - Role of monoclonal antibody drugs in the treatment of COVID-19
T2  - World Journal of Clinical Cases
TI  - Role of monoclonal antibody drugs in the treatment of COVID-19
UR  - https://www.wjgnet.com/2307-8960/about.htm
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998274
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i19.4280&issn=2307-8960&isbn=&volume=8&issue=19&spage=4280&pages=4280-4285&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Role+of+monoclonal+antibody+drugs+in+the+treatment+of+COVID-19&aulast=Ucciferri&pid=%3Cauthor%3EUcciferri+C.%2CVecchiet+J.%2CFalasca+K.%3C%2Fauthor%3E&%3CAN%3E632998274%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 8
ID  - 7782824
ER  - 

TY  - JOUR
AB  - One of the negative components of international travel is the higher likelihood of emergencies that affect a large number of people (mass negative impact on health), for example the transmission of infectious diseases, as e.g. SARS CoV-2 pandemic. The frequency and sources of mass-casualty incidents are currently changing dynamically, especially with the onset of terrorist attacks and large-scale natural disasters. Health services and emergency medical service (EMS) take part in addressing these emergencies. For this reason, this paper deals with the EMS emergency preparedness in the Czech Republic for an emergency events with a large number of affected people. EMS in the Czech Republic are not provided by the state but by individual regions. EMS in the Czech Republic do not have central management, nor do they use uniform data documentation. The investigation of the current situation has shown that the attitudes of EMS in individual regions of the Czech Republic to the tasks of emergency preparedness for mass casualty incidents are not identical. The current method of evaluating improvements in the quality of EMS emergency preparedness lacks consistency and is not comprehensively supervised. To tackle this, the paper presents an internal audit methodology for assessing the level of emergency preparedness of the emergency medical services. The authors therefore defined the decisive criteria and indicators assessing the quality level of EMS emergency preparedness at major disaster with multiple victim incident. When developing the methodological procedure of the preparedness evaluation, an algorithm was chosen, based on the gradual verification of the evaluation criteria and indicators by an expert group. Some findings and recommendations based on a research carried out in EMS in individual regions of the Czech Republic are presented.
AD  - Department of Security and Law, AMBIS College, Prague, Czech Republic.
Department of Defense Technologies, General Jonas �aemaitis Military Academy of Lithuania, Šilo Str. 5A, 10322 Vilnius, Lithuania. GRID: grid.466225.1. ISNI: 0000 0001 1015 4482
AN  - 33020672
AU  - Tu�Qer, I.
AU  - Beke�Qienė, S.
AU  - Navr֙til, J.
C1  - 10/6/2020
C2  - PMC7528452
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s11135-020-01039-w
DP  - NLM
ET  - 2020/10/07
J2  - Quality & quantity
KW  - Emergency management
Emergency medical services
Emergency preparedness
Evaluating
Major disaster
Multiple victim incident
LA  - eng
N1  - Tu�Qer, Irena
Orcid: 0000-0002-4667-8146
Beke�Qienė, Svajonė
Navr֙til, Josef
Journal Article
Netherlands
Qual Quant. 2020 Oct 1:1-13. doi: 10.1007/s11135-020-01039-w.
PY  - 2020
SN  - 0033-5177 (Print)
0033-5177
SP  - 1-13
ST  - Emergency management and internal audit of emergency preparedness of pre-hospital emergency care
T2  - Quality & quantity
TI  - Emergency management and internal audit of emergency preparedness of pre-hospital emergency care
ID  - 7785018
ER  - 

TY  - JOUR
AB  - Background. Sensitive and specific SARS-CoV-2 serologic assays are needed to inform diagnostic, therapeutic, and public health decision-making. We evaluated three commercial serologic assays as stand-alone tests and as components of two-test algorithms. Methods. Two nucleocapsid (Abbott IgG and Roche total antibody) and one spike-protein (DiaSorin IgG) antibody tests were included. We assessed sensitivity using 128 serum samples from symptomatic PCR-confirmed COVID-19-infected patients, and specificity using 1204 samples submitted for routine serologies prior to COVID-19's emergence, plus 64 pandemic-era samples from SARS-CoV-2 PCR-negative patients with respiratory symptoms. Assays were evaluated as stand-alone tests and as components of a two-test algorithm in which positive results obtained using one assay were verified using a second assay. Results. The two nucleocapsid antibody tests were more sensitive than the spike-protein antibody test overall (70% and 70% versus 57%; P�?.003), with pronounced differences observed using samples collected 7-14 days after symptom onset. All three assays were comparably sensitive (�?9%, P�?.13) using samples collected 14 days after symptom onset. Specificity was higher using the nucleocapsid antibody tests (99.3% and 99.7%) compared with the spike protein antibody test (97.8%, P�?.002). When any two assays were paired in a two-test algorithm, specificity was 99.9% (P0.0001 to 0.25 compared with the individual assays), and positive predictive value (PPV) improved substantially with minimal effect on negative predictive value (NPV). Conclusions. Two nucleocapsid antibody tests outperformed a spike protein antibody test. Pairing two different serologic tests in a two-test algorithm improves PPV compared with the individual assays alone, while maintaining NPV.
AD  - Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Undergraduate Medical Education Program, Harvard Medical School, Boston, MA, USA.
Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. branda.john@mgh.harvard.edu.
AN  - 33020186
AU  - Turbett, S. E.
AU  - Anahtar, M.
AU  - Dighe, A. S.
AU  - Garcia Beltran, W.
AU  - Miller, T.
AU  - Scott, H.
AU  - Durbin, S. M.
AU  - Bharadwaj, M.
AU  - Thomas, J.
AU  - Gogakos, T. S.
AU  - Astudillo, M.
AU  - Lennerz, J.
AU  - Rosenberg, E. S.
AU  - Branda, J. A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1128/jcm.01892-20
DP  - NLM
ET  - 2020/10/07
J2  - Journal of clinical microbiology
LA  - eng
N1  - 1098-660x
Turbett, Sarah E
Anahtar, Melis
Dighe, Anand S
Garcia Beltran, Wilfredo
Miller, Tyler
Scott, Hannah
Durbin, Sienna Marie
Bharadwaj, Maheetha
Thomas, Jason
Gogakos, Tasos S
Astudillo, Michael
Lennerz, Jochen
Rosenberg, Eric S
Branda, John A
Journal Article
United States
J Clin Microbiol. 2020 Oct 5:JCM.01892-20. doi: 10.1128/JCM.01892-20.
PY  - 2020
SN  - 0095-1137
ST  - Evaluation of Three Commercial SARS-CoV-2 Serologic Assays and their Performance in Two-Test Algorithms
T2  - Journal of clinical microbiology
TI  - Evaluation of Three Commercial SARS-CoV-2 Serologic Assays and their Performance in Two-Test Algorithms
ID  - 7785045
ER  - 

TY  - JOUR
AD  - (Troidl) Max-Planck-Institute for Heart and Lung Research, Ludwigstr. 43, Bad Nauheim 61231, Germany (Troidl) Fachbereich Life Sciences and Engineering, TH Bingen, Berlinstrasse 109, Bingen am Rhein 55411, Germany (Simon) Klinik fur Gefas- und Endovaskularchirurgie, Universitatsklinikum Dusseldorf, Heinrich-Heine-Universitat Dusseldorf, Moorenstrase 5, Dusseldorf 40225, Germany
K. Troidl, Max-Planck-Institute for Heart and Lung Research, Ludwigstr. 43, Bad Nauheim 61231, Germany. E-mail: kerstin.troidl@mpi-bn.mpg.de F. Simon, Fachbereich Life Sciences and Engineering, TH Bingen, Berlinstrasse 109, Bingen am Rhein 55411, Germany. E-mail: florian.simon@med.uni-duesseldorf.de
AN  - 2006846617
AU  - Troidl, K.
AU  - Simon, F.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1007/s00772-020-00700-w
DP  - Ovid Technologies
KW  - article
coronavirus disease 2019
human
personal experience
LA  - German
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 0948-7034
1434-3932
ST  - Student tuition during COVID-19: Two personal experiences from the first online semester 2020. [German]
T2  - Gefasschirurgie
TI  - Student tuition during COVID-19: Two personal experiences from the first online semester 2020. [German]
TT  - Lehrveranstaltungen in Zeiten von Covid-19: Zwei personliche Erfahrungen aus dem ersten Online-Semester 2020.
UR  - http://link.springer.de/link/service/journals/00772/index.htm
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006846617
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1007%2Fs00772-020-00700-w&issn=0948-7034&isbn=&volume=&issue=&spage=&pages=&date=2020&title=Gefasschirurgie&atitle=Lehrveranstaltungen+in+Zeiten+von+Covid-19%3A+Zwei+personliche+Erfahrungen+aus+dem+ersten+Online-Semester+2020&aulast=Troidl&pid=%3Cauthor%3ETroidl+K.%2CSimon+F.%3C%2Fauthor%3E&%3CAN%3E2006846617%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
ID  - 7783065
ER  - 

TY  - JOUR
AB  - INTRODUCTION: Since the beginning of the COVID-19 pandemic there has been some debate regarding the risk of transmission through tissue transplantation and tissue banking processes. AIM OF THE STUDY: To analyze the changes that SARS-CoV-2 has caused regarding the harvesting of corneal donor tissue and eye bank activities in Germany. METHODS: A questionnaire was provided to 26 eye banks in Germany, consisting of questions about adaptations made in the screening of potential donors and the harvesting of corneal tissue following the pandemic spread of SARS-CoV-2. RESULTS: Eighteen eye banks actively reduced recruitment of donors and two banks ceased all activity. Additional diagnostic screening was performed in eight banks, using conjunctival swabs and/or nasopharyngeal swabs. In six eye banks, additional protective measures, such as FFP2 masks and/or facial shields, were implemented. Overall, a mean reduction in the number of obtained donor tissues of 17% was observed. DISCUSSION: Conjunctival and/or nasopharyngeal swabs of donors have been implemented by a minority. Reasons for not performing additional tests may be moderate sensitivity and lack of validation for postmortem use of RT-PCR testing. Also, the hazard of SARS-CoV-2 entering the corneal donor pool with subsequent transmission might be perceived as theoretical. Face shields provide a sufficient barrier against splash and splatter contamination but may be insufficient against aerosols. Additional face masks would provide support against aerosols, but it remains debatable if corneal harvesting can be considered an aerosol-producing procedure. In the future we expect to see changes in current guidelines because of a surge in scientific activities to improve our understanding of the risks involved with cornea donation in the COVID-19 pandemic, and because current practice may reduce the availability of donor corneas due to new exclusion criteria while the demand remains unchanged.
AD  - Department of Ophthalmology, University of Düsseldorf , Düsseldorf, Germany.
Department of Ophthalmology, RWTH University Aachen , Aachen, Germany.
Institute of Transfusion Medicine, University Tissue Bank, Charité - Universitätsmedizin Berlin , Berlin, Germany.
Department of Ophthalmology, University of Erlangen-Nuremberg , Erlangen-Nuremberg, Germany.
Department of Ophthalmology, University of Essen , Essen, Germany.
Department of Ophthalmology, University of Freiburg , Freiburg, Germany.
Department of Ophthalmology, University of Hamburg , Hamburg, Germany.
Department of eye banking, Deutsche Gesellschaft Für Gewebetransplantation, Hannover, Germany.
Department of Ophthalmology, University of Heidelberg , Heidelberg, Germany.
Department of Ophthalmology, Saarland University Medical Center, UKS , Homburg, Saar, Germany.
Department of Ophthalmology, University of Kiel , Kiel, Germany.
Department of Ophthalmology, Städt. Kliniken Köln , Cologne, Germany.
Department of Ophthalmology, University of Cologne , Cologne, Germany.
Department of Ophthalmology, University of Mainz , Mainz, Germany.
Hornhautbank München gGmbH , Munich, Germany.
Department of Ophthalmology, University of Münster , Münster, Germany.
Department of Ophthalmology, University of Tübingen , Tübingen, Germany.
Department of Ophthalmology, University of Ulm , Ulm, Germany.
Department of Ophthalmology, University of Würzburg , Würzburg, Germany.
AN  - 33016144
AU  - Trigaux, C.
AU  - Salla, S.
AU  - Schroeter, J.
AU  - Tourtas, T.
AU  - Thomasen, H.
AU  - Maier, P.
AU  - Hellwinkel, O. J. C.
AU  - Wittmershaus, I.
AU  - Merz, P. R.
AU  - Seitz, B.
AU  - Nölle, B.
AU  - Schrage, N.
AU  - Roters, S.
AU  - Apel, M.
AU  - Gareiss-Lok, A.
AU  - Uhlig, C. E.
AU  - Thaler, S.
AU  - Raber, F.
AU  - Kampik, D.
AU  - Geerling, G.
AU  - Menzel-Severing, J.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1080/02713683.2020.1828487
DP  - NLM
ET  - 2020/10/06
J2  - Current eye research
KW  - Covid-19
SARS-CoV-2
cornea
corona virus
eye banking
tissue banking
transplantation
LA  - eng
N1  - 1460-2202
Trigaux, Céline
Salla, Sabine
Schroeter, Jan
Tourtas, Theofilos
Thomasen, Henning
Maier, Philip
Hellwinkel, Olaf J C
Wittmershaus, Ilka
Merz, Patrick R
Seitz, Berthold
Nölle, Bernhard
Schrage, Norbert
Roters, Sigrid
Apel, Melissa
Gareiss-Lok, Andrea
Uhlig, Constantin E
Thaler, Sebastian
Raber, Florian
Kampik, Daniel
Geerling, Gerd
Menzel-Severing, Johannes
Journal Article
England
Curr Eye Res. 2020 Oct 4:1-6. doi: 10.1080/02713683.2020.1828487.
PY  - 2020
SN  - 0271-3683
SP  - 1-6
ST  - SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks
T2  - Current eye research
TI  - SARS-CoV-2: Impact on, Risk Assessment and Countermeasures in German Eye Banks
ID  - 7785219
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To summarize available literature regarding headache as a manifestation of coronaviruses and to describe potential underlying mechanisms. REVIEW METHODS: References for this review were identified by searches within PubMed without any date restrictions. The search terms used were coronavirus disease 2019 (COVID-19) clinical manifestation, COVID-19 epidemiology, neurologic findings in COVID-19, headache in COVID-19, neurologic manifestations of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and headache in SARS-CoV-2. RESULTS: Headache is one of the most common neurologic complaints in patients with SARS-CoV-2. While the pathophysiological connection between headache and SARS-CoV-2 is unclear, inflammatory mechanisms may play a key role. One of the mechanisms cited in the literature of migraine and other headache disorders is the activation of nociceptive sensory neurons by cytokines and chemokines. A similar mechanism has been reported in SARS-CoV-2 with the release of cytokines and chemokines by macrophages throughout the course of infection. Other mechanisms for headache in SARS-CoV-2 include (1) viral neuroinvasion as seen with viral encephalitis; (2) hypoxemia due to the well-described pulmonary manifestations of the disease; and (3) thrombosis secondary to COVID-19 induced hypercoagulable states. CONCLUSION: According to the Centers for Disease Control, common symptoms of human coronavirus include fever, cough, runny nose, sore throat, and headache. In the case of SARS-CoV-2, there are limited reports about headaches, one of the most common clinical manifestations. There are currently no studies that focus specifically on headache among patients with SARS-CoV-2 infection.
AD  - Fellow in Headache and Facial Pain, Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
Neurology & Neurological Sciences, Stanford Medicine, Palo Alto, CA, USA.
Department of Neurology, Yale School of Medicine, New Haven, CT, USA.
AN  - 33017479
AU  - Tolebeyan, A. S.
AU  - Zhang, N.
AU  - Cooper, V.
AU  - Kuruvilla, D. E.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/head.13980
DP  - NLM
ET  - 2020/10/06
J2  - Headache
KW  - coronavirus disease 2019
headache
migraine
severe acute respiratory syndrome coronavirus 2
LA  - eng
N1  - 1526-4610
Tolebeyan, Amir Soheil
Zhang, Niushen
Cooper, Vanessa
Orcid: 0000-0003-2058-4085
Kuruvilla, Deena E
Journal Article
Review
United States
Headache. 2020 Oct 5. doi: 10.1111/head.13980.
PY  - 2020
SN  - 0017-8748
ST  - Headache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review
T2  - Headache
TI  - Headache in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Narrative Review
ID  - 7785131
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic caused by SARS-CoV-2 has now emerged as a global health problem and is responsible for high mortality and morbidity. The SARS-CoV-2 main protease (M(pro)) emerged as a promising drug target because of its essential role in the processing of polyproteins, which is translated from viral RNA. The present study reports a designed novel hybrid antiviral molecule (VTRRT-13.V2.1) against SARS-CoV2 main protease. A series of different combinations of hybrid antiviral were generated from nonspecific antiviral molecules currently used to control COVID-19. To enhance the specificity of the designed hybrid antiviral molecule, the core pocket region of the active site of M(pro) protein was targeted. In-silico screening, molecular mechanics, molecular dynamics simulation (MDS) analysis identified a hybrid VTRRT-13.V2 molecule. Retrosynthetic analysis and combinatorial synthesis generated 1000 analogs of VTRRT-13.V2 molecules. Docking, molecular mechanics, and MDS analysis selected VTRRT-13.V2.1 as a possible inhibitor for SARS-CoV2 main protease. Comparative analysis of all the results showed that VTRRT-13.V2.1 have the highest docking Glide score (-12.28 kcal/mol) and best binding energy (-52.23 kcal/mol) as compared to the other hybrid constructs such as VTRRT-13.V2 (-9.47 and -47.36 kcal/mol), VTRRT-13 (-8.9 and -47.55 kcal/mol), and current antiviral investigated. The mutational sensitivity screening showed that binding residues of M(pro) are not present in mutation hotspots. It was also observed that VTRRT-13.V2.1 does not have any human off-targets. SARS-CoV2 main protease is essential for the survival of this virus; hence, a designed novel hybrid antiviral molecule (VTRRT-13.V2.1) might be useful to control the infection of COVID-19 infection.
AD  - Department of Biochemistry, Central University of Rajasthan, Bandarsindri, Ajmer, 305817, India.
AN  - 33020742
AU  - Tiwari, V.
C1  - 10/6/2020
C2  - PMC7526676
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.heliyon.2020.e05122
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Heliyon
KW  - Bioinformatics
Hybrid antiviral molecule
In-silico designing
Infectious disease
Medical microbiology
Microbiology
Molecular dynamics simulation
Retro-combinatorial synthesis
SARS-CoV2 main protease
LA  - eng
N1  - Tiwari, Vishvanath
Journal Article
England
Heliyon. 2020 Oct;6(10):e05122. doi: 10.1016/j.heliyon.2020.e05122. Epub 2020 Sep 30.
PY  - 2020
SN  - 2405-8440 (Print)
2405-8440
SP  - e05122
ST  - Novel hybrid antiviral VTRRT-13V2.1 against SARS-CoV2 main protease: retro-combinatorial synthesis and molecular dynamics analysis
T2  - Heliyon
TI  - Novel hybrid antiviral VTRRT-13V2.1 against SARS-CoV2 main protease: retro-combinatorial synthesis and molecular dynamics analysis
VL  - 6
ID  - 7784984
ER  - 

TY  - JOUR
AB  - The worldwide pandemic of COVID-19, caused by the virus SARS-CoV-2, continues to cause significant morbidity and mortality in both low- and high-income countries. Although COVID-19 is predominantly a respiratory illness, other systems including gastrointestinal (GI) system and liver may be involved because of the ubiquitous nature of ACE-2 receptors in various cell lines that SARS-CoV-2 utilizes to enter host cells. It appears that GI symptoms and liver enzyme abnormalities are common in COVID-19. The involvement of the GI tract and liver correlates with the severity of disease. A minority (10-20%) of patients with COVID-19 may also present initially with only GI complaints. The most common GI symptoms are anorexia, loss of smell, nausea, vomiting, and diarrhea. Viral RNA can be detected in stool in up to 50% of patients, sometimes even after pharyngeal clearance, but it is unclear whether fecal-oral transmission occurs. Liver enzymes are elevated, usually mild (2-3 times), in a substantial proportion of patients. There are many confounding factors that could cause liver enzyme abnormalities including medications, sepsis, and hypoxia. Although infection rates in those with preexisting liver disease are similar to that of general population, once infected, patients with liver disease are more likely to have a more severe disease and a higher mortality. There is a paucity of objective data on the optimal preventive or management strategies, but few recommendations for GI physicians based on circumstantial evidence are discussed.
AD  - Institute of Digestive Health and Liver Diseases, Mercy Medical Center, Baltimore, MD, USA. thuluvath@gmail.com.
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. thuluvath@gmail.com.
Department of Internal Medicine, Barbara and Zucker School of Medicine for Hofstra/Northwell Health, Manhasset, NY, USA.
AN  - 33015748
AU  - Thuluvath, P. J.
AU  - Alukal, J. J.
AU  - Ravindran, N.
AU  - Satapathy, S. K.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1007/s10620-020-06625-4
DP  - NLM
ET  - 2020/10/06
J2  - Digestive diseases and sciences
KW  - Covid-19
Liver enzymes
Liver manifestations: GI symptoms
SARS-CoV-2
LA  - eng
N1  - 1573-2568
Thuluvath, Paul J
Alukal, Joseph J
Ravindran, Nishal
Satapathy, Sanjaya K
Journal Article
Review
United States
Dig Dis Sci. 2020 Oct 5. doi: 10.1007/s10620-020-06625-4.
PY  - 2020
SN  - 0163-2116
ST  - What GI Physicians Need to Know During COVID-19 Pandemic
T2  - Digestive diseases and sciences
TI  - What GI Physicians Need to Know During COVID-19 Pandemic
ID  - 7785252
ER  - 

TY  - JOUR
AB  - OBJECTIVE: This study aimed to explore the transmission of COVID-19 in a U.S. state psychiatric hospital setting. METHODS: Symptomatic and asymptomatic patients were tested throughout a large psychiatric hospital to determine penetrance. The hospital followed initial Centers for Disease Control and Prevention (CDC) guidelines. RESULTS: Seventy-eight percent (N=51 of 65) of tested patients in the building where the first positive patient was housed (building zero) tested positive for COVID-19. Eighty-eight percent (N=14 of 16) of tested asymptomatic patients in building zero were positive, compared with 12% (N=6 of 51) of randomly selected asymptomatic patients in a sample from the rest of the hospital. CONCLUSIONS: A high percentage of patients can become positive for COVID-19 despite following initial CDC guidelines. As such, use of masks by all patients in close-quarter settings prior to the first positive case appears warranted. Recent CDC guidelines align with this strategy.
AD  - Department of Psychiatry and Behavioral Sciences (Thompson, Mikolajewski), Department of Microbiology and Immunology (Smither), and Department of Pathology and Laboratory Medicine (Lin, Tian), Tulane University School of Medicine, New Orleans; Tulane University of School of Public Health and Tropical Medicine, New Orleans (Kissinger, McCrossen); LaCATS-Clinical Translational Unit, New Orleans (Chamarthi).
AN  - 33019856
AU  - Thompson, J. W., Jr.
AU  - Mikolajewski, A. J.
AU  - Kissinger, P.
AU  - McCrossen, P.
AU  - Smither, A.
AU  - Chamarthi, G. D.
AU  - Lin, Z.
AU  - Tian, D.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1176/appi.ps.202000270
DP  - NLM
ET  - 2020/10/07
J2  - Psychiatric services (Washington, D.C.)
KW  - Covid-19
asymptomatic transmission
inpatient services
penetrance
LA  - eng
N1  - 1557-9700
Thompson, John W Jr
Mikolajewski, Amy J
Kissinger, Patricia
McCrossen, Patrick
Smither, Allison
Chamarthi, Govind Datta
Lin, Zhen
Tian, Di
Journal Article
United States
Psychiatr Serv. 2020 Oct 6:appips202000270. doi: 10.1176/appi.ps.202000270.
PY  - 2020
SN  - 1075-2730
SP  - appips202000270
ST  - An Epidemiologic Study of COVID-19 Patients in a State Psychiatric Hospital: High Penetrance With Early CDC Guidelines
T2  - Psychiatric services (Washington, DC)
TI  - An Epidemiologic Study of COVID-19 Patients in a State Psychiatric Hospital: High Penetrance With Early CDC Guidelines
ID  - 7785083
ER  - 

TY  - GEN
AN  - NCT04576312
AU  - therapeutics, UNION
C1  - 10/6/2020
DA  - June 29
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - covid-19
N1  - No Results Available
Drug: UNI911 INHALATION
Assess safety of UNI911 INHALATION in healthy volunteers: AE frequency
All
Phase 1
44
Industry
Allocation: Randomized|Intervention Model: Sequential Assignment|Masking: Single (Investigator)|Primary Purpose: Other
UNI911-101
December 31, 2020
PB  - https://ClinicalTrials.gov/show/NCT04576312
PY  - 2020
ST  - Study to Assess the Safety of Ascending Doses of UNI911 INHALATION in Healthy Volunteers in Preparation for Evaluation in Adults With COVID-19
T2  - ClinicalTrials
TI  - Study to Assess the Safety of Ascending Doses of UNI911 INHALATION in Healthy Volunteers in Preparation for Evaluation in Adults With COVID-19
UR  - https://ClinicalTrials.gov/show/NCT04576312
ID  - 7788847
ER  - 

TY  - JOUR
AU  - Thennakoon, Nishadi
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Central Bank Independence, Accountability, Challenges for Central Banks
PY  - 2020
ST  - Central Banks Are not Strangers to Unpopularity (preprint)
T2  - SSRN
TI  - Central Banks Are not Strangers to Unpopularity (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3692960
ID  - 7788910
ER  - 

TY  - JOUR
AB  - Interest continues to grow regarding the role of serologic assays for the detection of prior infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The U.S. Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) status to many SARS-CoV-2 serologic assays. In this document, expert recommendations from clinical microbiologist members of the American Society for Microbiology (ASM) concerning detailed verification strategies for SARS-CoV-2 serologic assays with FDA EUA are provided, as are insights into assay limitations and reporting considerations for laboratories. Assessments concerning single and multi-antibody isotype detection assays, which may provide either differentiated or non-differentiated (i.e., total antibody) antibody class results, are addressed. Additional considerations prior to assay implementation are also discussed, including biosafety, quality control and proficiency testing strategies. As the landscape of SARS-CoV-2 serologic testing is rapidly changing, this document provides updated guidance for laboratorians on application of these assays.
AD  - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT.
ARUP Laboratories, Salt Lake City, UT.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Department of Pathology, Wake Forest Baptist Medical Center, Medical Center Boulevard, Winston-Salem, NC.
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Department of Laboratory Medicine, Yale School of Medicine, West Haven, CT.
Department of Pathology and Laboratory Medicine, VA Connecticut Health Care, West Haven, CT.
College of Public Health, University of Iowa, Iowa City, IA.
State Hygienic Laboratory, University of Iowa, Coralville, IA.
Department of Pathology, Keck School of Medicine of USC, Los Angeles, CA.
Department of Pathology and Area Laboratory Services, Madigan Army Medical Center, Joint Base Lewis-McChord, WA.
American Society for Microbiology, Washington, DC.
AN  - 33020185
AU  - Theel, E. S.
AU  - Couturier, M. R.
AU  - Filkins, L.
AU  - Palavecino, E.
AU  - Mitchell, S.
AU  - Campbell, S.
AU  - Pentella, M.
AU  - Butler-Wu, S.
AU  - Jerke, K.
AU  - Dharmarha, V.
AU  - McNult, P.
AU  - Schuetz, A. N.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1128/jcm.02148-20
DP  - NLM
ET  - 2020/10/07
J2  - Journal of clinical microbiology
LA  - eng
N1  - 1098-660x
Theel, Elitza S
Orcid: 0000-0002-6886-2294
Couturier, Marc Roger
Filkins, Laura
Palavecino, Elizabeth
Mitchell, Stephanie
Orcid: 0000-0002-1777-7591
Campbell, Sheldon
Pentella, Michael
Butler-Wu, Susan
Orcid: 0000-0001-5372-8706
Jerke, Kurt
Dharmarha, Vaishali
McNult, Peggy
Schuetz, Audrey N
Orcid: 0000-0002-5837-270x
American Society for Microbiology Clinical and Public Health Microbiology Committee, Subcommittee on Laboratory Practices
Journal Article
United States
J Clin Microbiol. 2020 Oct 5:JCM.02148-20. doi: 10.1128/JCM.02148-20.
PY  - 2020
SN  - 0095-1137
ST  - Application, Verification and Implementation of SARS-CoV-2 Serologic Assays with Emergency Use Authorization
T2  - Journal of clinical microbiology
TI  - Application, Verification and Implementation of SARS-CoV-2 Serologic Assays with Emergency Use Authorization
ID  - 7785046
ER  - 

TY  - JOUR
AB  - The current COVID-19 pandemics is having a major impact on our global health and economies. There is widespread recognition that ecosystem disruption, including land-use change and illegal wildlife trade, is linked to the increasing emergence of zoonotic diseases. Here, we emphasize that protected areas play a fundamental role in buffering against novel disease outbreaks by maintaining ecosystem integrity. However, protected areas worldwide are facing increasing human pressures, which are being amplified by the unfolding COVID-19 crisis. Increased resources are thus urgently needed to mainstream a One Health approach to protected area management, focusing specifically on i) monitoring illegal wildlife trade, ii) biodiversity trends and iii) surveillance of zoonotic pathogens. Improving integration of public healthinto global biodiversity conservation policies should be a top priority to reduce the risk of future pandemics.
AD  - Global Change Ecology Research Group, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
Helsinki Institute of Sustainability Science (HELSUS), Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland.
AN  - 33014191
AU  - Terraube, J.
AU  - Fern֙ndez-Llamazares, Á
C1  - 10/6/2020
C2  - PMC7525266
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.cosust.2020.08.014
DP  - NLM
ET  - 2020/10/06
J2  - Current opinion in environmental sustainability
LA  - eng
N1  - 1877-3443
Terraube, Julien
Fern֙ndez-Llamazares, Álvaro
Journal Article
Curr Opin Environ Sustain. 2020 Sep 30. doi: 10.1016/j.cosust.2020.08.014.
PY  - 2020
SN  - 1877-3435 (Print)
1877-3435
ST  - Strengthening protected areas to halt biodiversity loss and mitigate pandemic risks
T2  - Current opinion in environmental sustainability
TI  - Strengthening protected areas to halt biodiversity loss and mitigate pandemic risks
ID  - 7785417
ER  - 

TY  - JOUR
AU  - Taxt, Arne Michael
AU  - Grødeland, Gunnveig
AU  - Lind, Andreas
AU  - Müller, Fredrik
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 13
LA  - en
PY  - 2020
ST  - Status for vaksineutvikling mot covid-19
T2  - Journal of the Norwegian Medical Association
TI  - Status for vaksineutvikling mot covid-19
TT  - Status for vaksineutvikling mot covid-19.
Status of COVID-19 vaccine development.
UR  - https://dx.doi.org/10.4045/tidsskr.20.0676
VL  - 140
ID  - 7788776
ER  - 

TY  - JOUR
AB  - Importance: Accurate understanding of COVID pandemic during the first viral wave in Canada could help prepare for future epidemic waves. Objective: To track the early course of the pandemic by examining self-reported COVID symptoms over time before testing became widely available. Design: Adults from the nationally representative Angus Reid Forum were randomly invited to complete an online survey in May/June 2020. The study is a part of the Action to Beat Coronavirus antibody testing study. Setting: A 20-item internet survey. Participants: 14,408 adults age 18 years of age. Exposures: The months that respondents and any household members first experienced various respiratory, neurological, sleep, skin or gastric symptoms. Main Outcomes and Measure: COVID symptom-positive, defined as fever (or fever with hallucinations) plus at least one of difficulty breathing, a dry severe cough, loss of smell or COVID toe. Results: In total, 14,408 panel members (48% male and 52% female) completed the survey. Despite overrepresentation of higher levels of education, the prevalence of obesity, smoking, diabetes and hypertension were similar to national census and health surveys. A total of 811 (5.6%) were COVID symptom-positive; highest rates were at ages 18-44 years (8.3% among), declining at older ages. Females had higher odds of reporting COVID symptoms (OR = 1.32, 95%CI 1.11-1.56) as did visible minorities (OR = 1.74, 1.29-2.35). COVID symptom positivity for respondents and their household members peaked in March (OR = 1.93, 95% CI = 1.59-2.34 compared to earlier months). Conclusions and Relevance: This study enhances our current understanding of the progression of the COVID epidemic in Canada, with few laboratory-confirmed cases in January and February, peaking in April. The results suggest substantial viral transmission in March, before widespread testing began, and a gradual decline in cases since May.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by the Canadian Institutes of Health Research Foundation grant (grant number FDN 154277); and Pfizer Canada (grant number 61608943). PJ is a Canada Research Chair and Dalla Lana Chair of Global Health at the University of Toronto, and received the above grants.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The Unity Health Toronto Research Ethics Board approved this study (REB# 20-107).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data that support the findings of the Ab-C Study are available on request from the corresponding author PJ. The request is also subject to the approval of the Unity Health Toronto Research Ethics Board.
AU  - Tang, Xuyang
AU  - Gelband, Hellen
AU  - Lam, Teresa
AU  - Nagelkerke, Nico
AU  - Reid, Angus
AU  - Jha, Prabhat
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205930
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205930
ST  - A national study of self-reported COVID symptoms during the first viral wave in Canada (preprint)
T2  - medRxiv
TI  - A national study of self-reported COVID symptoms during the first viral wave in Canada (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205930.abstract
ID  - 7788881
ER  - 

TY  - JOUR
AB  - The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses its spike (S) protein to mediate viral entry into host cells. Cleavage of the S protein at the S1/S2 and/or S2�?site is known to activate the S protein for viral entry, which can occur at either the cell plasma membrane or the endosomal membrane. Previous studies show that SARS-CoV-2 has a unique insert at the S1/S2 site that can be cleaved by furin, which expands viral tropism to lung cells. Here, we analyze the presence of a furin S1/S2 site in related CoVs and offer thoughts on the implications of the unique insert the origin of SARS-CoV-2. We also utilized viral pseudoparticles to study the impact of the S1/S2 cleavage on infectivity. Our results demonstrate that S1/S2 pre-cleavage is essential for plasma membrane entry into Calu-3 cells, a model lung epithelial cell line, but not for endosomal entry Vero E6 cells, a model cell culture line, and that other proteases in addition to furin are responsible for processing SARS-CoV-2 S1/S2.Competing Interest StatementThe authors have declared no competing interest.
AU  - Tang, Tiffany
AU  - Jaimes, Javier A.
AU  - Bidon, Miya K.
AU  - Straus, Marco R.
AU  - Daniel, Susan
AU  - Whittaker, Gary R.
C1  - 10/6/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.04.325522
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.04.325522
ST  - Proteolytic activation of the SARS-CoV-2 spike S1/S2 site: a re-evaluation of furin cleavage (preprint)
T2  - bioRxiv
TI  - Proteolytic activation of the SARS-CoV-2 spike S1/S2 site: a re-evaluation of furin cleavage (preprint)
UR  - http://biorxiv.org/content/early/2020/10/05/2020.10.04.325522.abstract
ID  - 7788886
ER  - 

TY  - JOUR
AB  - The ongoing pandemic of Coronavirus disease 19 (COVID-19) is caused by a newly discovered β Coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination. Here we examined, using ELISA, the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6-7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection. All samples were positive for IgGs against the S- and N-proteins of SARS-CoV-2. Notably, 14 samples available at 6-7 months post-infection all showed significant neutralizing activities in a pseudovirus assay, with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2. Furthermore, in 10 blood samples from cases at 6-7 months post-infection used for memory T-cell tests, we found that interferon ��-producing CD4(+) and CD8(+) cells were increased upon SARS-CoV-2 antigen stimulation. Together, these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population, and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2.
AD  - Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Shanghai Public Health Clinical Center, Shanghai, 201508, China.
National Institutes for Food and Drug Control (NIFDC), Beijing, 102629, China.
Shanghai Public Health Clinical Center, Shanghai, 201508, China. luhongzhou@shphc.org.cn.
Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. sjchen@stn.sh.cn.
AN  - 33017040
AU  - Tan, Y.
AU  - Liu, F.
AU  - Xu, X.
AU  - Ling, Y.
AU  - Huang, W.
AU  - Zhu, Z.
AU  - Guo, M.
AU  - Lin, Y.
AU  - Fu, Z.
AU  - Liang, D.
AU  - Zhang, T.
AU  - Fan, J.
AU  - Xu, M.
AU  - Lu, H.
AU  - Chen, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1007/s11684-020-0822-5
DP  - NLM
ET  - 2020/10/06
J2  - Frontiers of medicine
KW  - SARS-CoV-2
T-cell response
neutralizing antibodies
LA  - eng
N1  - 2095-0225
Tan, Yun
Liu, Feng
Xu, Xiaoguang
Ling, Yun
Huang, Weijin
Zhu, Zhaoqin
Guo, Mingquan
Lin, Yixiao
Fu, Ziyu
Liang, Dongguo
Zhang, Tengfei
Fan, Jian
Xu, Miao
Lu, Hongzhou
Chen, Saijuan
Journal Article
China
Front Med. 2020 Oct 5. doi: 10.1007/s11684-020-0822-5.
PY  - 2020
SN  - 2095-0217
ST  - Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
T2  - Frontiers of medicine
TI  - Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
ID  - 7785166
ER  - 

TY  - JOUR
AB  - BACKGROUND: A large number of the population experienced panic during the pandemic of the coronavirus disease 2019 (COVID-19) in China. The current study explored the trajectory of panic and its associated factors to develop promising strategies for controlling the global spread of COVID-19 and improving the mental health emergency management. METHODS: A total of 812 unmarried adults (aged from 18 to 42 years, M = 23.3, SD = 3.45) from all over China participated online in our investigation. A Growth Mixture Model (GMM) was developed and analysed. RESULTS: Three classes of trajectories for panic were identified: the "continuous decline group (CDG)", the "continuous low group (CLG)," and the "continuous high group (CHG)". With reference to the CDG, people in the CHG were more sensitive to social factors. With reference to the CDG, people in the CLG were more likely to possess some of the following traits: being men, in Hubei Province (center of the pandemic), with a lower income, and less sensitive towards social factors and individual factors. With reference to the CLG, people in the CHG were more likely to be women, located outside of Hubei Province, and more sensitive to social factors, family factors, and individual factors. CONCLUSION: Social factors, family factors, and individual factors predicted the different trajectories of panic.
AD  - Faculty of Psychology, Beijing Normal University, China.
Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, China.
AN  - 33016617
AU  - Tan, Y.
AU  - Lin, X.
AU  - Wu, D.
AU  - Chen, H.
AU  - Jiang, Y.
AU  - He, T.
AU  - Yin, J.
AU  - Tang, Y.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/aphw.12238
DP  - NLM
ET  - 2020/10/06
J2  - Applied psychology. Health and well-being
KW  - Covid-19
family factors
individual factors
panic
social factors
trajectory
LA  - eng
N1  - 1758-0854
Tan, Yuxin
Lin, Xiuyun
Orcid: 0000-0001-6006-2893
Wu, Dazhou
Chen, Hui
Jiang, Yongqiang
He, Ting
Yin, Jinxiu
Tang, Yingying
The COVID-19 Mental Health Support Project of the Department of Psychology of Beijing Normal University/
310430002/The COVID-19 Prevention and Research Emergency Project of Beijing Normal University/
2018YFC0810600/National Key R&D Program of China/
Journal Article
England
Appl Psychol Health Well Being. 2020 Oct 5. doi: 10.1111/aphw.12238.
PY  - 2020
SN  - 1758-0854
ST  - Different Trajectories of Panic and the Associated Factors among Unmarried Chinese during the COVID-19 Pandemic
T2  - Applied psychology Health and well-being
TI  - Different Trajectories of Panic and the Associated Factors among Unmarried Chinese during the COVID-19 Pandemic
ID  - 7785192
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The Singapore Armed Forces (SAF) recognises the potential benefits and looks to harnessing telemedicine for primary health care services. In this prospective self-controlled pilot study, we aimed to evaluate the safety, efficiency and user satisfaction outcomes of virtual care (VC) at a military medical centre. METHODS: Out of 320 patients seen during the study period, 28 were enrolled in this study and underwent on-premises VC, comprising digital symptoms collection and telemedicine in addition to the usual in-person physician consultation. Safety outcomes were measured based on the diagnostic concordance between physicians. Efficiency was measured based on consultation times, and user satisfaction was evaluated using a standard questionnaire. RESULTS: There was a higher caseload of both upper respiratory infections and dermatological conditions in our population, in which telemedicine performed well. In terms of safety, telemedicine achieved a mean diagnostic concordance of 92.8% compared to in-person consultations. In terms of efficiency, consultation times were 26.2% - or 2 minutes and 15 seconds - shorter on average with telemedicine (p�?�?.0488). User satisfaction was favourable, with 85.5% of patients satisfied with the VC experience. DISCUSSION: This study has been invaluable in showing that on-premises telemedicine is a safe, efficient and effective means to extend and increase our surge capacity for primary health care. Our results have given us reasonable confidence to explore a larger-scale implementation in our network of military medical centres in the future.
AD  - Singapore Armed Forces Medical Corps, Singapore.
AN  - 33016187
AU  - Tan, N. G.
AU  - Yang, L. W.
AU  - Tan, M. Z.
AU  - Chng, J.
AU  - Tan, M. H.
AU  - Tan, C.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/1357633x20959579
DP  - NLM
ET  - 2020/10/06
J2  - Journal of telemedicine and telecare
KW  - Covid-19
Telemedicine
general practice
military medicine
on-premises telemedicine
symptoms collection
telehealth
virtual care
LA  - eng
N1  - 1758-1109
Tan, Nan-Guang
Orcid: 0000-0001-7099-3691
Yang, Lily Wei-Yun
Tan, Mark Zhong-Wei
Chng, Jeremiah
Tan, Marcus Hong-Tat
Tan, Clive
Journal Article
England
J Telemed Telecare. 2020 Oct 4:1357633X20959579. doi: 10.1177/1357633X20959579.
PY  - 2020
SN  - 1357-633x
SP  - 1357633x20959579
ST  - Virtual care to increase military medical centre capacity in the primary health care setting: A prospective self-controlled pilot study of symptoms collection and telemedicine
T2  - Journal of telemedicine and telecare
TI  - Virtual care to increase military medical centre capacity in the primary health care setting: A prospective self-controlled pilot study of symptoms collection and telemedicine
ID  - 7785212
ER  - 

TY  - JOUR
AB  - STUDY DESIGN: This was a cross-sectional study. OBJECTIVE: The objective of this study is to report the impact of COVID-19 on spine surgery fellow education and readiness for practice. SUMMARY OF BACKGROUND DATA: COVID-19 has emerged as one of the most devastating global health crises of our time. To minimize transmission risk and to ensure availability of health resources, many hospitals have cancelled elective surgeries. There may be unintended consequences of this decision on the education and preparedness of current surgical trainees. MATERIALS AND METHODS: A multidimensional survey was created and distributed to all current AO Spine fellows and fellowship directors across the United States and Canada. RESULTS: Forty-five spine surgery fellows and 25 fellowship directors completed the survey. 62.2% of fellows reported 50% decrease in overall case volume since cancellation of elective surgeries. Mean hours worked per week decreased by 56.2%. Fellows reported completing a mean of 188.4�u64.8 cases before the COVID-19 crisis and 84.1% expect at least an 11%-25% reduction in case volume compared with previous spine fellows. In all, 95.5% of fellows did not expect COVID-19 to impact their ability to complete fellowship. Only 2 directors were concerned about their fellows successfully completing fellowship; however, 32% of directors reported hearing concerns regarding preparedness from their fellows and 25% of fellows were concerned about job opportunities. CONCLUSIONS: COVID-19 has universally impacted work hours and case volume for spine surgery fellows set to complete fellowship in the middle of 2020. Nevertheless, spine surgery fellows generally feel ready to enter practice and are supported by the confidence of their fellowship directors. The survey highlights a number of opportunities for improvement and innovation in the future training of spine surgeons. LEVEL OF EVIDENCE: Level III.
AD  - Department of Orthopaedic Surgery, Northwestern University, Chicago, IL.
Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY.
Department of Neurological Surgery, Northwestern University, Chicago, IL.
AN  - 33017340
AU  - Swiatek, P. R.
AU  - Weiner, J. A.
AU  - Butler, B. A.
AU  - McCarthy, M. H.
AU  - Louie, P. K.
AU  - Wolinsky, J. P.
AU  - Hsu, W. K.
AU  - Patel, A. A.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1097/bsd.0000000000001073
DP  - NLM
ET  - 2020/10/06
J2  - Clinical spine surgery
LA  - eng
N1  - 2380-0194
Swiatek, Peter R
Weiner, Joseph A
Butler, Bennet A
McCarthy, Michael H
Louie, Philip K
Wolinsky, Jean-Paul
Hsu, Wellington K
Patel, Alpesh A
Journal Article
United States
Clin Spine Surg. 2020 Oct 2. doi: 10.1097/BSD.0000000000001073.
PY  - 2020
SN  - 2380-0186
ST  - Assessing the Early Impact of the COVID-19 Pandemic on Spine Surgery Fellowship Education
T2  - Clinical spine surgery
TI  - Assessing the Early Impact of the COVID-19 Pandemic on Spine Surgery Fellowship Education
ID  - 7785143
ER  - 

TY  - JOUR
AB  - OBJECTIVE: This study aims to present clinical characteristics of 30 hospitalized cases with epileptic seizure and coronavirus disease 2019(COVID-19).　 METHODS: This is a retrospective observational research. Clinical data were extracted from electronic medical records in 1550 patients with laboratory-confirmed diagnosis of COVID-19 who hospitalized in Wuhan Central Hospital, China, from 1 January to 31 April, 2020. 30 COVID-19 patients with the diagnosis of epilepsy were enrolled. The clinical characteristics, complications, treatments,and clinical outcomes of 30 cases were collected. RESULT: Of 30 patients with diagnosis of epilepsy and COVID-19, 13 patients(43.4%) had new-onset epileptic seizure without epilepsy history(new-onset seizure group,NS group), 10 patients(33.3%) with epilepsy history had recurrent epileptic seizure(recurrent seizure group,RS group) and 7 patients(23.3%) with epilepsy history had no seizure during the course of COVID-19 (epilepsy history group,EH group). Patients in RS group had more other neurological disease history except for epilepsy than those in NS group and EH group(7/10[70%] VS 1/13 [7.7%]VS1/7[14.3%]), and the difference between RS group and NS group is significant (P �?.05). Patients in NE group and RS group suffered more severe/critical COVID-19 infection than patients in EH group (10/13[76.9%] VS 6/10[60%] VS 1/7[14.3%]),and the difference between NS group and EH group is significant (P �?.05). 36.7% of patients had 1 to 5 complications,and 46.4% of patients had 6-10 complications.The complications in patients with seizure(in RS group and NS group) seem to be more than those without seizure(in EH group), but it doesn't have statistic difference. The proportion of antiepileptic drugs (AEDs) treatment before admission was higher in EH group than in RE group(7/7 [100%] VS 2/10 [20%], P �?.05). The mortality of 30 patients with epilepsy and COVID-19 was 36.67%. The mortality of NS group(38.5%) and RS group(50%) were a little higher than in EH group(14.3%). None of convalescent patients had recurrent seizure, and there was no more death in the 3 month follow-up after discharge. CONCLUSIONS: COVID-19 Patients with recurrent epileptic seizure had more underlying neurological diseases than patients who had epilepsy history but without seizure.Patients with new-onset and recurrent epileptic seizure suffered more sever/critical COVID-19, which may lead to a worse prognosis.If patients with epilepsy history continue using AEDs during COVID-19 pandemics, the risk of recurrent seizure may reduce, and a good prognosis for patients with epilepsy history could be expected.
AD  - Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430021, China.
Department of Pharmacy, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430021, China.
Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, 430021, China. Electronic address: zhm7001@163.com.
AN  - 33017697
AU  - Sun, M.
AU  - Ruan, X.
AU  - Li, Y.
AU  - Wang, P.
AU  - Zheng, S.
AU  - Shui, G.
AU  - Li, L.
AU  - Zhang, H.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.ijid.2020.09.1475
DP  - NLM
ET  - 2020/10/06
J2  - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
KW  - Covid-19
clinical outcomes
complication
epilepsy
new-onset
recurrent
seizure
LA  - eng
N1  - 1878-3511
Sun, Minxian
Ruan, Xiaoyun
Li, Yuanyuan
Wang, Pei
Zheng, Shasha
Shui, Guiying
Li, Li
Zhang, Hongmei
Journal Article
Canada
Int J Infect Dis. 2020 Oct 2:S1201-9712(20)32191-3. doi: 10.1016/j.ijid.2020.09.1475.
PY  - 2020
SN  - 1201-9712
ST  - Clinical characteristics of 30 COVID-19 patients with epilepsy: a retrospective study in Wuhan
T2  - International journal of infectious diseases : IJID : official publication of International Society for Infectious Diseases
TI  - Clinical characteristics of 30 COVID-19 patients with epilepsy: a retrospective study in Wuhan
ID  - 7785121
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has caused millions of infections and hundreds of thousands deaths in the world. The pandemic is still ongoing and no specific antivirals have been found to control COVID-19. The integration of Traditional Chinese Medicine with supportive measures of Modern Medicine has reportedly played an important role in the control of COVID-19 in China. This review summarizes the evidence of TCM in the treatment of COVID-19 and discusses the plausible mechanism of TCM in control of COVID-19 and other viral infectious diseases. Copyright © 2020 Bentham Science Publishers.
AD  - (Sun) Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, United States
J. Sun, Department of Biological Sciences and Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, United States. E-mail: jsun@utep.edu
AN  - 2005153623
AU  - Sun, J.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.2174/2212697X07999200623130743
DP  - Ovid Technologies
IS  - 2
KW  - (SARSCoV-2)
Antivirals
covid-19
Modern medicine
Pandemic
Traditional chinese medicine
article
China
Chinese medicine
coronavirus disease 2019
human
virus infection
antivirus agent
LA  - English
PY  - 2020
SN  - 2212-697X
2212-6988
SP  - 89-94
ST  - 1+1 2: Integration of the host-directed traditional chinese medicine and the virus-targeted modern medicine in control of covid-19
T2  - Clinical Cancer Drugs
TI  - 1+1 2: Integration of the host-directed traditional chinese medicine and the virus-targeted modern medicine in control of covid-19
UR  - https://www.eurekaselect.com/184668/article
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005153623
VL  - 7
ID  - 7782978
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The SARS-CoV-2 virus has forced profound change on all aspects of society, with significant impact on dental education. Dental students like all other dental clinical personnel are considered to be at the highest risk amongst health care workers due to the nature of treatment, namely, working in the oral cavity (known reservoir for the virus) and the routine use of aerosol generating procedures. The nature of this pandemic has created several challenges to dental clinical education. The aim of this paper is to discuss these challenges and how educators have sought to overcome them. MATERIALS AND METHODS: This paper reviews the evidence base around bio-aerosol and infection control measures specifically in the context of dental education. RESULTS: Using current knowledge of bio-aerosol and increasing understanding of the virus dental educators can implement evidence-based measures to ensure safe teaching within both simulation and clinical environments. DISCUSSION: This paper contextualises the current pandemic in a dental education setting by providing a critical appraisal of the challenges posed by SARS-CoV-2 and how these challenges may be managed. CONCLUSION: The SARS-CoV-2 pandemic has created unique challenges for dental schools world-wide. Dental educators have sought to identify these challenges and find solutions appropriate to the stage of the pandemic specific to their geographical location.
AD  - Sydney Dental School, Faculty of Medicine and Health, University of Sydney.
3M Australia, Scientific Affairs and Education Manager, Australia/New Zealand Oral Care Division.
AN  - 33015929
AU  - Sukumar, S.
AU  - Dracopoulos, S. A.
AU  - Martin, F. E.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/eje.12608
DP  - NLM
ET  - 2020/10/06
J2  - European journal of dental education : official journal of the Association for Dental Education in Europe
KW  - Covid-19
aerosol
clinical teaching
dental education
simulation
LA  - eng
N1  - 1600-0579
Sukumar, Smitha
Orcid: 0000-0001-8202-3748
Dracopoulos, Susie Athanasia
Martin, Fjelda Elizabeth
Journal Article
England
Eur J Dent Educ. 2020 Oct 4. doi: 10.1111/eje.12608.
PY  - 2020
SN  - 1396-5883
ST  - Dental Education in the Time of SARS-CoV-2
T2  - European journal of dental education : official journal of Association for Dental Education in Europe
TI  - Dental Education in the Time of SARS-CoV-2
ID  - 7785235
ER  - 

TY  - JOUR
AD  - Centre for Research and Intervention on Suicide, Ethical Issues and End-of-Life Practices, Université du Québec à Montréal, Montreal, Quebec, Canada.
Department of Psychology, Université du Québec à Montréal, Montreal, Quebec, Canada.
AN  - 33016982
AU  - Stijelja, S.
AU  - Mishara, B. L.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1001/jamainternmed.2020.3271
DP  - NLM
ET  - 2020/10/06
J2  - JAMA internal medicine
LA  - eng
N1  - 2168-6114
Stijelja, Stefan
Mishara, Brian L
Journal Article
United States
JAMA Intern Med. 2020 Oct 5. doi: 10.1001/jamainternmed.2020.3271.
PY  - 2020
SN  - 2168-6106
ST  - COVID-19 and Psychological Distress-Changes in Internet Searches for Mental Health Issues in New York During the Pandemic
T2  - JAMA internal medicine
TI  - COVID-19 and Psychological Distress-Changes in Internet Searches for Mental Health Issues in New York During the Pandemic
ID  - 7785170
ER  - 

TY  - JOUR
AD  - Thomas Jefferson University, Jefferson College of Population Health, Philadelphia, Pennsylvania, USA.
Agenus, Lexington, Massachusetts, USA.
AN  - 33017282
AU  - Stefanacci, R.
AU  - Buffa, A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1089/pop.2020.0228
DP  - NLM
ET  - 2020/10/06
J2  - Population health management
KW  - Covid-19
Program of All-inclusive Care for the Elderly (PACE)
full-risk programs
managed care organizations
population health programs
LA  - eng
N1  - 1942-7905
Stefanacci, Richard
Buffa, Alexa
Journal Article
United States
Popul Health Manag. 2020 Oct 5. doi: 10.1089/pop.2020.0228.
PY  - 2020
SN  - 1942-7891
ST  - Full-Risk Population Health Programs for Older Adults Like PACE Benefit from COVID-19
T2  - Population health management
TI  - Full-Risk Population Health Programs for Older Adults Like PACE Benefit from COVID-19
ID  - 7785144
ER  - 

TY  - JOUR
AB  - The JAMA research letter “Association of Stay-at-Home Orders with COVID-19 Hospitalizations in 4 States�?fails placebo tests. Actual cumulative COVID-19 hospitalizations fall below the projections from univariate exponential time trend models in states with and without stay-at-home orders. No conclusions can be drawn about the association of stay-at-home orders with COVID-19 hospitalizations from the evidence in the letter.
AN  - 2448233022
AU  - Spry, John A.
C1  - 10/6/2020
DA  - Sep 2020
2020-10-05
DB  - ProQuest Central
DP  - ProQuest Central
IS  - 2
KW  - Business And Economics--Economic Systems And Theories, Economic History
pandemic
coronavirus
exponential growth
Shelter in place
Coronaviruses
Hospitalization
COVID-19
LA  - English
N1  - Copyright - Copyright Fraser Institute Sep 2020
PY  - 2020
SP  - 270-278
ST  - Comment on Sen, Karaca-Mandic, and Georgiou on Stay-at-Home Orders and COVID-19 Hospitalizations in Four States
T2  - Econ Journal Watch
TI  - Comment on Sen, Karaca-Mandic, and Georgiou on Stay-at-Home Orders and COVID-19 Hospitalizations in Four States
UR  - https://www.proquest.com/docview/2448233022?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Comment+on+Sen%2C+Karaca-Mandic%2C+and+Georgiou+on+Stay-at-Home+Orders+and+COVID-19+Hospitalizations+in+Four+States&title=Econ+Journal+Watch&issn=&date=2020-09-01&volume=17&issue=2&spage=270&au=Spry%2C+John+A&isbn=&jtitle=Econ+Journal+Watch&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 17
ID  - 7784903
ER  - 

TY  - JOUR
AB  - Since January 30, 2020, when the World Health Organization declared the SARS CoV-2 disease (COVID-19) to be a public health emergency of international concern, the National Library of Medicine's (NLM's) Web Collecting and Archiving Working Group has been collecting a broad range of web-based content about the emerging pandemic for preservation in an Internet archive. Like NLM's other Global Health Events web collections, this content will have enduring value as a multifaceted historical record for future study and understanding of this event. This article describes the scope of the COVID-19 project; some of the content captured from websites, blogs, and social media; collecting criteria and methods; and related COVID-19 collecting efforts by other groups. The growing collection-2,500 items as of June 30, 2020-chronicles the many facets of the pandemic: epidemiology; vaccine and drug research; disease control measures and resistance to them; effects of the pandemic on health care institutions and workers, education, commerce, and many aspects of social life; effects for especially vulnerable groups; role of health disparities in infection and mortality; and recognition of racism as a public health emergency.
AD  - speakes1@nih.gov, Historian for the Digital Manuscripts Program, History of Medicine Division, National Library of Medicine, Bethesda, MD.
christie.moffatt@nih.gov, Manager of the Digital Manuscripts Program, History of Medicine Division, and Chair, Web Collecting and Archiving Working Group, National Library of Medicine, Bethesda, MD.
AN  - 33013228
AU  - Speaker, S. L.
AU  - Moffatt, C.
C1  - 10/6/2020
C2  - PMC7524615
DA  - Oct 1
DB  - PubMed
DO  - 10.5195/jmla.2020.1090
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Journal of the Medical Library Association : JMLA
LA  - eng
N1  - 1558-9439
Speaker, Susan L
Moffatt, Christie
Journal Article
J Med Libr Assoc. 2020 Oct 1;108(4):656-662. doi: 10.5195/jmla.2020.1090.
PY  - 2020
SN  - 1536-5050 (Print)
1536-5050
SP  - 656-662
ST  - The National Library of Medicine Global Health Events web archive, coronavirus disease (COVID-19) pandemic collecting
T2  - Journal of Medical Library Association : JMLA
TI  - The National Library of Medicine Global Health Events web archive, coronavirus disease (COVID-19) pandemic collecting
VL  - 108
ID  - 7785479
ER  - 

TY  - JOUR
AB  - OBJECTIVE: The aim of this study is to compare the effects of COVID-19 on urology practice using pre- and post-pandemic data of a pandemic hospital. MATERIAL AND METHODS: March 11 is considered as the beginning of COVID-19 and, changes in the number of the outpatient clinic examinations, non-surgical procedures, and surgery in the 8-week period before and during the pandemic were evaluated by weeks. Age, gender, and comorbid diseases of the operated patients were compared statistically. The symptoms, complaints, mortality, and morbidity conditions of the patients were recorded by contacting them. Descriptive data and chi-square test were used. RESULTS: The number of COVID-19 cases has been reported as 8,916 for the hospital, 88,412 for the city and 150,593 for the country. The mean age of the operated patients before and after 11 March was 51 and 47, and comorbidities were 79 and 40, respectively, and there was no statistically significant difference(p0.05). The number of patients examined was 2,309 and 868, the number of operated patients 173 and 94, the number of patients undergoing non-surgical procedures were 371 and 174, respectively. The names and numbers of surgical and non-surgical procedures are listed according to European Association of Urology (EAU) priority classification. In follow-up, no complication because of COVID-19 was observed in any patient. CONCLUSION: Our study showed that, although the numbers have decreased, similar operations can be performed in daily urology practice without any contamination and mortality during the pandemic compared to the prepandemic period, by taking precautions and following the algorithms.
AD  - Department of Urology, İstanbul Medipol University Faculty of Medicine, İstanbul, Turkey.
AN  - 33016868
AU  - Soytaş, M.
AU  - Boz, M. Y.
AU  - Güzelburç, V.
AU  - Çal�\k, G.
AU  - Horuz, R.
AU  - Akbulut, Z.
AU  - Albayrak, S.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.5152/tud.2020.20230
DP  - NLM
ET  - 2020/10/06
J2  - Turkish journal of urology
LA  - eng
N1  - Soytaş, Mustafa
Orcid: 0000-0002-3474-3510
Boz, Mustafa Yücel
Orcid: 0000-0002-0159-2090
Güzelburç, Vahit
Orcid: 0000-0001-9988-2944
Çal�\k, Gökhan
Orcid: 0000-0002-9976-9666
Horuz, Rahim
Orcid: 0000-0001-8014-2321
Akbulut, Ziya
Orcid: 0000-0001-7146-4767
Albayrak, Selami
Orcid: 0000-0002-4245-7506
Journal Article
Turkey
Turk J Urol. 2020 Oct 1. doi: 10.5152/tud.2020.20230.
PY  - 2020
SN  - 2149-3235 (Print)
2149-3235
ST  - Comparison of before and after COVID-19 urology practices of a pandemic hospital
T2  - Turkish journal of urology
TI  - Comparison of before and after COVID-19 urology practices of a pandemic hospital
ID  - 7785173
ER  - 

TY  - JOUR
AB  - We present results on the mortality statistics of the COVID-19 epidemic in a number of countries. Our data analysis suggests classifying countries in five groups, (1) Western countries, (2) East Block, (3) developed Southeast Asian countries, (4) Northern Hemisphere developing countries and (5) Southern Hemisphere countries. Comparing the number of deaths per million inhabitants, a pattern emerges in which the Western countries exhibit the largest mortality rate. Furthermore, comparing the running cumulative death tolls as the same level of outbreak progress in different countries reveals several subgroups within the Western countries and further emphasises the difference between the five groups. Analysing the relationship between deaths per million and life expectancy in different countries, taken as a proxy of the preponderance of elderly people in the population, a main reason behind the relatively more severe COVID-19 epidemic in the Western countries is found to be their larger population of elderly people, with exceptions such as Norway and Japan, for which other factors seem to dominate. Our comparison between countries at the same level of outbreak progress allows us to identify and quantify a measure of efficiency of the level of stringency of confinement measures. We find that increasing the stringency from 20 to 60 decreases the death count by about 50 lives per million in a time window of 20  days. Finally, we perform logistic equation analyses of deaths as a means of tracking the dynamics of outbreaks in the "first wave" and estimating the associated ultimate mortality, using four different models to identify model error and robustness of results. This quantitative analysis allows us to assess the outbreak progress in different countries, differentiating between those that are at a quite advanced stage and close to the end of the epidemic from those that are still in the middle of it. This raises many questions in terms of organisation, preparedness, governance structure and so on.
AD  - Tokyo Tech World Research Hub Initiative (WRHI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama, 226-8502 Japan. GRID: grid.32197.3e. ISNI: 0000 0001 2179 2105
Institute of Risk Analysis, Prediction and Management (Risks-X), Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech), Shenzhen, 518055 China. GRID: grid.263817.9
Department of Management, Technology and Economics, ETH Zurich, Scheuchzerstrasse 7, 8092, Zurich, Switzerland. GRID: grid.5801.c. ISNI: 0000 0001 2156 2780
Gavekal Intelligence Software, 75016 Paris, France.
AN  - 33020681
AU  - Sornette, D.
AU  - Mearns, E.
AU  - Schatz, M.
AU  - Wu, K.
AU  - Darcet, D.
C1  - 10/6/2020
C2  - PMC7527427
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s11071-020-05966-z
DP  - NLM
ET  - 2020/10/07
J2  - Nonlinear dynamics
KW  - COVID-19 epidemic
Life expectancy
Logistic equation
Mortality
Outbreak progress
Stringency of confinement measures
LA  - eng
N1  - Sornette, Didier
Mearns, Euan
Schatz, Michael
Orcid: 0000-0003-1691-5558
Wu, Ke
Darcet, Didier
Journal Article
Netherlands
Nonlinear Dyn. 2020 Oct 1:1-26. doi: 10.1007/s11071-020-05966-z.
PY  - 2020
SN  - 0924-090X (Print)
0924-090x
SP  - 1-26
ST  - Interpreting, analysing and modelling COVID-19 mortality data
T2  - Nonlinear dynamics
TI  - Interpreting, analysing and modelling COVID-19 mortality data
ID  - 7785012
ER  - 

TY  - JOUR
AB  - Telehealth appears useful to fill in the void for home-ventilated patients to maintain the much-needed connectivity with their healthcare team during the #COVID19 pandemic https://bit.ly/3ftvjxW.
AD  - Pulmonology Unit, Dept of Medicine, National University of Malaysia (UKM) Medical Centre, Kuala Lumpur, Malaysia.
Dept of Anaesthesiology, Intensive Care and Pain Medicine, Director of Home Ventilation and Respiratory Support Service, Tan Tock Seng Hospital, Singapore.
Palliative Unit, Dept of Medicine, Faculty of Medicine, University of Malaya Medical Centre, Jalan Universiti, Kuala Lumpur, Malaysia.
Division of Respiratory Medicine, Dept of Medicine, Faculty of Medicine, University of Malaya Medical Centre, Jalan Universiti, Kuala Lumpur, Malaysia.
AN  - 33015149
AU  - Soo, C. I.
AU  - Chan, Y.
AU  - Loh, E. C.
AU  - Pang, Y. K.
C1  - 10/6/2020
C2  - PMC7520173 Chan has nothing to disclose. Conflict of interest: E.C. Loh has nothing to disclose. Conflict of interest: Y.K. Pang has nothing to disclose.
DA  - Jul
DB  - PubMed
DO  - 10.1183/23120541.00399-2020
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - ERJ open research
LA  - eng
N1  - 2312-0541
Soo, Chun Ian
Orcid: 0000-0001-8560-7888
Chan, Yeow
Loh, Ee Chin
Pang, Yong Kek
Journal Article
ERJ Open Res. 2020 Sep 28;6(3):00399-2020. doi: 10.1183/23120541.00399-2020. eCollection 2020 Jul.
PY  - 2020
SN  - 2312-0541 (Print)
2312-0541
ST  - Telehealth: "virtual" lifeline for home-ventilated patients during the COVID-19 pandemic
T2  - ERJ open research
TI  - Telehealth: "virtual" lifeline for home-ventilated patients during the COVID-19 pandemic
VL  - 6
ID  - 7785328
ER  - 

TY  - JOUR
AB  - The novel coronavirus pandemic that has originated from China and spread throughout the world in three months. Genome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) predecessor, severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) play an important role in understanding the concept of genetic variation. In this paper, the genomic data accessed from National Center for Biotechnology Information (NCBI) through Molecular Evolutionary Genetic Analysis (MEGA) for statistical analysis. Firstly, the Bayesian information criterion (BIC) and Akaike information criterion (AICc) are used to evaluate the best substitution pattern. Secondly, the maximum likelihood method used to estimate of transition/transversions (R) through Kimura-2, Tamura-3, Hasegawa-Kishino-Yano, and Tamura-Nei nucleotide substitutions model. Thirdly and finally nucleotide frequencies computed based on genomic data of NCBI. The results indicate that general times reversible model has the lowest BIC and AICc score 347,394 and 347,287, respectively. The transition/transversions bias for nucleotide substitutions models varies from 0.56 to 0.59 in MEGA output. The average nitrogenous bases frequency of U, C, A, and G are 31.74, 19.48, 28.04, and 20.74, respectively in percentages. Overall the genomic data analysis of SARS-CoV-2, SARS-CoV, and MERS-CoV highlights the close genetic relationship.
AD  - Department of Chemical & Bio Engineering, Beant College of Engineering & Technology, Gurdaspur 143521, India.
AN  - 33017874
AU  - Sohpal, V. K.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.5808/GI.2020.18.3.e30
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - Genomics & informatics
KW  - Middle East respiratory syndrome
Molecular Evolutionary Genetic Analysis
National Center for Biotechnology Information
SARS-CoV
SARS-CoV-2
LA  - eng
N1  - Sohpal, Vipan Kumar
Journal Article
Korea (South)
Genomics Inform. 2020 Sep;18(3):e30. doi: 10.5808/GI.2020.18.3.e30. Epub 2020 Sep 24.
PY  - 2020
SN  - 1598-866X (Print)
1598-866x
SP  - e30
ST  - Computational analysis of SARS-CoV-2, SARS-CoV, and MERS-CoV genome using MEGA
T2  - Genomics & informatics
TI  - Computational analysis of SARS-CoV-2, SARS-CoV, and MERS-CoV genome using MEGA
VL  - 18
ID  - 7785113
ER  - 

TY  - JOUR
AB  - COVID-19 infection caused by SARS-CoV2 virus is an acute respiratory illness which was declared as a pandemic by the World Health Organization. Usually, SARS-CoV2 infects independently and can cause spectrum of disease ranging from mild illness to severe progressive pneumonia, multiorgan dysfunction, and death; however, co-infections with other respiratory pathogens have been noted. Here, we present 2 fatal cases with co-infection, one with parainfluenza-4 virus and other co-infection/secondary infection with Streptococcus pneumoniae bacteria. Further studies are needed to study the effect of co-infections on morbidity and mortality of patients and establish the outcome of such infections.
AD  - Department of Internal Medicine, AMITA Health Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA ; Department of Infectious Diseases, AMITA Health Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA ; Department of Pulmonary Medicine and Critical Care, AMITA Health Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA ; Department of Internal Medicine, AMITA Health Saint Francis Hospital, 355 Ridge Avenue, Evanston, IL 60202, USA
AN  - 2448262879
AU  - Sohal, Sumit
AU  - Rodriguez-Nava, Guillermo
AU  - Khabbaz, Ramzy
AU  - Chaudry, Sana
AU  - Musurakis, Clio
AU  - Chitrakar, Solab
AU  - Chundi, Vishnu V.
AU  - Friedman, Harvey J.
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/8882348
DP  - ProQuest Central
KW  - Medical Sciences--Communicable Diseases
Viruses
Coronaviruses
Bacterial infections
COVID-19
China
LA  - English
N1  - Name - World Health Organization; New England Journal of Medicine
Copyright - Copyright © 2020 Sumit Sohal et al. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
SubjectsTermNotLitGenreText - China
PY  - 2020
SN  - 20906625
ST  - SARS-CoV2 and Co-Infections: A Review of Two Cases
T2  - Case Reports in Infectious Diseases
TI  - SARS-CoV2 and Co-Infections: A Review of Two Cases
UR  - https://www.proquest.com/docview/2448262879?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=SARS-CoV2+and+Co-Infections%3A+A+Review+of+Two+Cases&title=Case+Reports+in+Infectious+Diseases&issn=20906625&date=2020-01-01&volume=2020&issue=&spage=&au=Sohal%2C+Sumit%3BRodriguez-Nava%2C+Guillermo%3BKhabbaz%2C+Ramzy%3BChaudry%2C+Sana%3BMusurakis%2C+Clio%3BChitrakar%2C+Solab%3BChundi%2C+Vishnu+V%3BFriedman%2C+Harvey+J&isbn=&jtitle=Case+Reports+in+Infectious+Diseases&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F8882348
VL  - 2020
ID  - 7784937
ER  - 

TY  - JOUR
AB  - The most severe clinical feature of COVID-19 is Acute Respiratory Distress Syndrome (ARDS) which requires intubation and mechanical ventilation and it occurs in approximately 2.3% of cases. About 94% of of these cases end in death. This case series report two confirmed COVID-19 patients who had met criteria of intubation and mechanical ventilation, but not performed to them. Both patients experienced clinical improvement and recovery. Probably this is due to differences of COVID-19 ARDS (CARDS) with typical or classic ARDS.  CARDS is divided into two phenotypes of type L (Low Elastance) and type H (High Elastance). These different phenotypic also distinguish subsequent pathophysiology and clinical management. These phenotype can be differentiate by chest CT scan. This case series emphasizes the importance of understanding this phenotype so that clinicians can provide more appropriate treatment management and also availability of CT scans in health facilities that manage COVID -19.
AD  - Division of Respirology and Critical Care, Departement of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran. aysoeroto@yahoo.co.id.
AN  - 33020338
AU  - Soeroto, A. Y.
AU  - Hartantri, Y.
AU  - Perkusi, J. E.
AU  - Ferdian, F.
AU  - Rehimat, U.
AU  - Suryadinata, H.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Ards
Cards
Covid-19
Mechanical Ventilation
Thorax CT-Scan
LA  - eng
N1  - Soeroto, Arto Yuwono
Hartantri, Yovita
Perkusi, Jipi E
Ferdian, Ferdy
Rehimat, Undang
Suryadinata, Hendarsyah
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):274-282.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 274-282
ST  - Report of Two COVID-19 ARDS (CARDS) Cases Who Survived without Intubation and Mechanical Ventilation
T2  - Acta medica Indonesiana
TI  - Report of Two COVID-19 ARDS (CARDS) Cases Who Survived without Intubation and Mechanical Ventilation
VL  - 52
ID  - 7785032
ER  - 

TY  - JOUR
AB  - Crop agriculture and food production constantly face climactic challenges to the supply of safe, nutritious food. These challenges highlight the importance of innovation resulting in improved crop technologies, capable of providing consistently increasing yields in the face of abiotic and biotic stresses. This article addresses the challenge that regulatory barriers are, and can, have on the adoption of innovative crop and food technologies that improve food security. Evidence of increased crop yield and the potential for increased yields, are presented from innovative plant breeding technologies, especially gene editing. Recent advances from the use of gene editing in the pharmaceutical field may offer opportunities to reduce regulatory burdens.
AD  - Department of Agricultural and Resource Economics, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan, S7N 5A8, Canada.
AN  - 33014703
AU  - Smyth, S. J.
C1  - 10/6/2020
C2  - PMC7521901
DA  - Sep
DB  - PubMed
DO  - 10.1016/j.gfs.2020.100440
DP  - NLM
ET  - 2020/10/06
J2  - Global food security
KW  - Biotechnology
Crispr
Covid-19
Gene editing
Innovation
Regulatory burden
personal relationships that could have appeared to influence the work reported in
this paper.
LA  - eng
N1  - 2211-9124
Smyth, Stuart J
Journal Article
Glob Food Sec. 2020 Sep;26:100440. doi: 10.1016/j.gfs.2020.100440. Epub 2020 Sep 28.
PY  - 2020
SN  - 2211-9124 (Print)
SP  - 100440
ST  - Regulatory barriers to improving global food security
T2  - Global food security
TI  - Regulatory barriers to improving global food security
VL  - 26
ID  - 7785373
ER  - 

TY  - JOUR
AB  - Importance: An observant Chinese doctor Li Wenliang became the first physician to alert the world about COVID-19. Being an ophthalmologist himself, he has put the additional onus on us. The fact that the ocular manifestation could be the first presenting feature of novel coronavirus pneumonia should not be ignored and the possibility of spread of SARS-CoV-2 through the ocular secretions cannot be ruled out. However, with breakthroughs still evolving about this disease, the calls are now louder for closer examination on the pathogenesis of conjunctivitis associated with it. Hence, we conducted a scoping review of all available literature till date to fill in the "potential" gaps in currently available knowledge on ocular manifestations of SARS-CoV-2 infection in an attempt to establish continuity in the "chain of information" from December 2019 till April 2020. We also summarize a possible hypothesis on much less understood and highly debated topics on regard to the etiopathogenesis of ocular involvement in SARS-CoV-2 based on either presence or absence of ACE2 receptor in the ocular surface. Method(s): We conducted a scoping review search of published and unpublished SARS-CoV-2-related English language articles from December 2019 till mid of April 2020 from the online databases. The findings were summarized using text, tables, diagrams, and flowcharts. Result(s): The commonest ocular manifestation in SARS-CoV-2 infection is follicular conjunctivitis and has been the first manifestation of SARS-CoV-2 infection in 3 reported cases till date. The ocular surface inoculated with the SARS-CoV-2 leads to the facilitation of the virus to the respiratory system via the lacrimal passage. RT-PCR analysis of the ocular secretions has shown the presence of the SARS-CoV-2 nucleotides indicating the possibility of infection of ocular secretions. ACE2 receptors and its expression on the ocular mucosal surface are linked behind the etiopathogenesis of conjunctivitis. Conclusion(s): Conjunctivitis can be the presenting manifestation but may go unnoticed due to its mild nature. The ocular surface could serve as the entry gateway for the virus and ocular secretions could play a role in virus shed. The eye care personnel, as well as the general people, need to be more vigilant and adopt protective eye measures. Copyright © 2020 Kharel Sitaula et al.
AD  - (Sitaula) Department of Ophthalmology, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal (Khatri) Birat Eye Hospital, Biratnagar, Nepal (Janani) Sankara Nethralaya Referral Laboratory, Medical Research Foundation, Chennai, India (Mandage) Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India (Sadhu) Department of Optometry, The SankaraNethralaya Academy, Unit of Medical Research Foundation, Chennai, India (Madhavan) Larson & Turbo Microbiology Research Center, Sankara Nethralaya Referral Laboratory, Chennai, India (Upadhyay) Children Hospital for Eye, Ear Nose Throat and Rehabilitation Services, Bhaktapur, Nepal (Biswas) Department of Uvea and Ocular Pathology, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, India
A. Khatri, Birat Eye Hospital, Biratnagar, Nepal. E-mail: anadikc@gmail.com
AN  - 2005150249
AU  - Sitaula, R. K.
AU  - Khatri, A.
AU  - Janani, M. K.
AU  - Mandage, R.
AU  - Sadhu, S.
AU  - Madhavan, H. N.
AU  - Upadhyay, M. P.
AU  - Biswas, J.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.2147/OPTH.S259857
DP  - Ovid Technologies
KW  - 2019-nCOV
ACE2 receptor
Conjunctiva
Coronavirus
COVID-19 infection
Ocular
Ophthalmic
SARS-CoV-2
bodily secretions
case report
clinical article
conjunctivitis
coronavirus disease 2019
English (language)
eye care professional
eye infection
facilitation
human
learning
ophthalmology
polymerase chain reaction
protein expression
respiratory system
review
angiotensin converting enzyme 2
endogenous compound
nucleotide
LA  - English
M3  - Review
PY  - 2020
SN  - 1177-5467
1177-5483
SP  - 2807-2820
ST  - Unfolding covid-19: Lessons-in-learning in ophthalmology
T2  - Clinical Ophthalmology
TI  - Unfolding covid-19: Lessons-in-learning in ophthalmology
UR  - https://www.dovepress.com/getfile.php?fileID=61874
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005150249
VL  - 14
ID  - 7782988
ER  - 

TY  - JOUR
AU  - Singh, J. A.
AU  - Habib, A.
AU  - Jansen, J.
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 7
KW  - Advisory Committees
Coronavirus Infections
Dissent and Disputes
Freedom
Pandemics
Pneumonia, Viral
Public Health
Speech
Betacoronavirus
Government
Humans
Politics
South Africa
LA  - en
PY  - 2020
SP  - 578-580
ST  - Freedom of speech and public interest, not allegiance, should underpin science advisement to government
T2  - S Afr Med J
TI  - Freedom of speech and public interest, not allegiance, should underpin science advisement to government
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812928
VL  - 110
ID  - 7788470
ER  - 

TY  - JOUR
AB  - The government of India implemented social distancing interventions to contain the COVID-19 epidemic. However, effects of these interventions on epidemic dynamics are yet to be understood. Rates of laboratory-confirmed COVID-19 infections per day and effective reproduction number (R(t) ) were estimated for 7 periods (Pre-lockdown, Lockdown Phases 1 to 4 and Unlock 1-2) according to nationally implemented interventions with phased relaxation. Adoption of these interventions was estimated using Google mobility data. Estimates at the national level and for 12 Indian states most affected by COVID-19 are presented. Daily case rates ranged from 0·03 to 285.60/10 million people across 7 discrete periods in India. From 18 May to 31 July 2020, the NCT of Delhi had the highest case rate (999/10 million people/day), whereas Madhya Pradesh had the lowest (49/10 million/day). Average R(t) was 1.99 (95% CI 1.93-2.06) and 1.39 (95% CI 1.38-1.40) for the entirety of India during the period from 22 March 2020 to 17 May 2020 and from 18 May 2020 to 31 July 2020, respectively. Median mobility in India decreased in all contact domains during the period from 22 March 2020 to 17 May 2020, with the lowest being 21% in retail/recreation, except home which increased to 129% compared to the 100% baseline value. Median mobility in the 'Grocery and Pharmacy' returned to levels observed before 22 March 2020 in Unlock 1 and 2 and the enhanced mobility in the Pharmacy sector needs to be investigated. The Indian government imposed strict contact mitigation, followed by a phased relaxation, which slowed the spread of COVID-19 epidemic progression in India. The identified daily COVID-19 case rates and R(t) will aid national and state governments in formulating ongoing COVID-19 containment plans. Furthermore, these findings may inform COVID-19 public health policy in developing countries with similar settings to India.
AD  - School of Public Health & Zoonoses, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, 141004, India.
Sydney School of Veterinary Science, The University of Sydney, 425 Werombi Road, Camden, 2570 NSW, Australia.
Dept. of Veterinary Microbiology, University of Saskatchewan, Canada.
Dept. of Community Health Sciences, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada, T2N 4N1, Ontario.
One Health at UCalgary, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada, T2N 4N1.
Dept. of Medicine, Cumming School of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada, T2N 4N1, Ontario.
Dept. of Production Animal Health, Faculty of Veterinary Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Canada, T2N 4N1, Ontario.
Dept. of Mathematics and Statistics, Faculty of Science, University of Calgary, 2500 University Drive NW, Calgary, AB, Canada, T2N 1N4.
AN  - 33012088
AU  - Singh, B. B.
AU  - Lowerison, M.
AU  - Lewinson, R. T.
AU  - Vallerand, I. A.
AU  - Deardon, R.
AU  - Gill, J. P.
AU  - Singh, B.
AU  - Barkema, H. W.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/tbed.13868
DP  - NLM
ET  - 2020/10/05
J2  - Transboundary and emerging diseases
KW  - Covid-19
Epidemic dynamics
India
Public health interventions
LA  - eng
N1  - 1865-1682
Singh, Balbir B
Orcid: 0000-0002-6823-6146
Lowerison, Mark
Lewinson, Ryan T
Vallerand, Isabelle A
Deardon, Rob
Gill, J֙tinder Ps
Singh, Baljit
Barkema, Herman W
Orcid: 0000-0002-9678-8378
Journal Article
Germany
Transbound Emerg Dis. 2020 Oct 4. doi: 10.1111/tbed.13868.
PY  - 2020
SN  - 1865-1674
ST  - Public health interventions slowed but did not halt the spread of COVID-19 in India
T2  - Transboundary and emerging diseases
TI  - Public health interventions slowed but did not halt the spread of COVID-19 in India
ID  - 7785626
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Coronavirus infections, including SARS, MERS and COVID-19 have significant impact on global health as well as on pregnancies. The aim of this review was to enlighten and summarize the cumulative knowledge regarding the relationship between Coronavirus outbreaks and pregnancy. MATERIALS AND METHODS: Literature search was commenced in order to analyze the maternofetal effects of Coronavirus outbreaks. RESULTS: Fever and cough are the most common presenting symptoms of COVID-19 which mostly affects pregnant women in their 3rd trimester with a maternal mortality rate of  0-77%  and fetal and neonatal mortality rates of 1.2%. Fetal demise is common in critically ill pregnant. Pregnancy seems as a worsening factor for SARS and MERS epidemics and both infections affect prominently 3rd trimester pregnancies, although abortion (57%) is a significant risk for cases of early pregnancy. Clinical course of COVID-19, SARS and MERS may be rapid and worse in pregnant women than non-pregnant individuals. Cesarean section is the choice of delivery in most reported women due to mostly obstetrical reasons, although vaginal delivery seems not a worsening factor for the disease. CONCLUSIONS: COVID-19, SARS and MERS have significant detrimental effect on pregnancy. Rapid intervention, treatment, and intensive care support are essential for infected pregnant. Timely delivery is important in order to avoid intrauterine fetal death.
AD  - K�\rşehir Ahi Evran University, Faculty of Medicine, Obstetrics and Gynecology Department, K�\rşehir, Turkey. dryavuzsimsek@gmail.com.
AN  - 33015821
AU  - Simsek, Y.
AU  - Ciplak, B.
AU  - Songur, S.
AU  - Kara, M.
AU  - Karahocagil, M. K.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23068
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Simsek, Y
Ciplak, B
Songur, S
Kara, M
Karahocagil, M K
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9748-9752. doi: 10.26355/eurrev_202009_23068.
PY  - 2020
SN  - 1128-3602
SP  - 9748-9752
ST  - Maternal and fetal outcomes of COVID-19, SARS, and MERS: a narrative review on the current knowledge
T2  - European review for medical and pharmacological sciences
TI  - Maternal and fetal outcomes of COVID-19, SARS, and MERS: a narrative review on the current knowledge
VL  - 24
ID  - 7785244
ER  - 

TY  - JOUR
AB  - Objective: The new type of Corona virus (SARS-CoV-2) is the most important item on the agenda, currently affecting our world. The number of cases has exceeded millions and the number of dead has exceeded hundreds of thousands. The precautions to be taken by societies and individuals, especially states, will undoubtedly be the most important task at the end of this epidemic. In our study, analyzes the data and consequences regarding COVID-19, making use of worldwide experiences and national statistics. In the report writing process, evidence-based and scientific tables and charts were used. In these times when most citizens have just begun to encounter the word pandemic, this report has been prepared using the data and scientific facts of the Ministry of Health of the Republic of Turkey. In this study, it was aimed to evaluate "contact tracing management" (detection, referral and follow-up) studies for positive cases with COVID-19 test results and their contacts in Ankara. Methods: With the Laboratory Information Management System (LBYS), Public Health Management System (HSYS), Contact Tracing and Isolation Tracking System (FITAS) and the Family Medicine Information System (AHBS) prepared by our Ministry, the COVID-19 test results in Ankara were directed towards the "the Our study, which aims to evaluate contact tracing management" (detection, referral and follow-up) studies, is a descriptive study. Within the scope of the research, the studies between March 11, 2020 and May 31, 2020 were examined. In order to use the data in the study, permission was obtained from the General Directorate of Public Health of the Ministry of Health of the Republic of Turkey. dated 06/12/2020 and numbered 119016548. Results: In Ankara, the number of contacts per case is 4.07 and the number of contact tracing per case is 4.05. With a total of 398 "Field Contact Tracing Teams" consisting of 1 doctor and 2 health care personnel throughout the city, the average of 50 �u standard deviations reached 99.4% within hours. Conclusion: The most effective way to prevent the spread of the virus; the epidemic is expected to be brought under control by public health interventions such as mask use, social distance, hand washing, hygiene rules, infection prevention activities such as indoor ventilation and contact management made through Field Contact Tracing Teams" and Family Medicine providing service across the country with GPS-based mobile application FITAS. © 2020 Refik Saydam National Public Health Agency (RSNPHA).
AD  - Ankara Provincial Health Directorate, Ankara, Turkey
Hacettepe University Faculty of Medicine, Ankara, Turkey
Gazi University Faculty of Medicine, Ankara, Turkey
T.C. Ministry of Health, General Directorate of Public Health, Ankara, Turkey
AU  - Şimşek, A. C.
AU  - Kara, A.
AU  - Baran-Aksakal, F. N.
AU  - Gülüm, M.
AU  - Ilter, B.
AU  - Ender, L.
AU  - Bulut, Y. E.
AU  - Gül, H.
AU  - Irmak, H.
AU  - Altunay, K.
AU  - Çakmak, D.
AU  - Tosun, E.
AU  - Gülegen, E. C.
AU  - Demirkasimoğlu, M.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.5505/TurkHijyen.2020.80688
IS  - 3
J2  - Turk Hijyen Deney. Biyoloji Dergisi
KW  - Contact tracing
COVID-19
COVID-19 pandemic control
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Şimşek, A.C.; Ankara Provincial Health DirectorateTurkey; email: cigdemsimsek2000@yahoo.com
References: Sağlik Bakanliği, T.C., Halk Sağliği Genel Müdürlüğü, COVID-19 (SARS-CoV-2 Enfeksiyonu) Rehberi, , 14 Nisan 2020, Ankara; Sağlik Bakanliği, T.C., (2017) Halk Sağliği Genel Müdürlüğü, Bulaşici Hastaliklar I˙le Mücadele Rehberi, , Ankara; (2006) Hacettepe Üniversitesi Yayinlari, pp. 865-887. , Sayfa: Ankara; Epidemiyoloji, T., (2017) Sabahat Güven Tezcan, Hipokrat Yayinevi, pp. 190-209. , Sayfa: Ankara; (2020) Coronavirus Disease (COVID-19) events as they happen [online], , https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen, Website: [accessed 28 April 2020]; Sağlik Bakanliği, T.C., (2019) Halk Sağliği Genel Müdürlüğü, Pandemik I˙nfluenza Ulusal Hazirlik Plani, , Ankara; (2019), Ankara; Demirbilek, Y., Pehlivantürk, G., Özgüler, Z., Alp Meşe E. COVID-19 Outbreak control, example of Ministry of Health of Turkey (2020) Turkish Journal of Medical Sciences, 50, pp. 489-494; Nussbaumer-Streit, B., Quarantine alone or in combination with other public healthmeasures to control COVID-19: A rapid review Cochrane Database of Systematic Reviews; Boccia, S., Ricciardi, W., Ioannidis, J., What other countries can learn from italy during the COVID-19 Pandemic (2020) JAMA Intern Med, , Published online April 7; Anelli, F., Italian doctors call for protecting healthcare workers and boosting community surveillance during Covid-19 outbreak (2020) BMJ, , 368:m1254 (Published 26 March 2020); (2020) Rational use of personal protective equipment for coronavirus disease (COVID-19), , interim guidance, 27 February; Choi, J.Y., Covid-19 in South Korea (2020) Postgrad Med J, p. ii. , May 4. postgradmedj-2020-137738. [Epub ahead of print]; Cha, V., (2020) A Timeline of South Korea's response to COVID-19, , https://www.csis.org/analysis/timeline-south-koreas-response-covid-19, March 27; Cheng, H.-Y., Jian, S.-W., Contact tracing assessment of COVID-19 transmission dynamics in taiwan and risk at different exposure periods before and after symptom onset (2020) JAMA Intern Med, , May 1; Wölfel, R., Corman, V.M., Guggemos, W., Virological assessment of hospitalized patients with COVID-2019 (2020) Nature, , published online April 1; He, X., Lau, E.H.Y., Wu, P., Temporal dynamics in viral shedding and transmissibility of COVID-19 (2020) Nat Med, , published April 15; Ferretti, L., Wymant, C., Kendall, M., Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing (2020) Science, , published online March 31; Salathé, M., Althaus, C., Neher, R., Stringhini, S., Hodcroft, E., Fellay, J., Zwahlen, M., Low, N., COVID-19 Epidemic in Switzerland: On the Importance of Testing, Contact Tracing and Isolation (2020) Swiss Med Wkly, 150; Steinbrook, R., (2020) Testing, and Control of COVID-19-Learning From Taiwan JAMA Intern Med, , Published online May 1, [Epub ahead of print]; (2020) Covid-19 Pandemi Değerlendirme Raporu, Turkish Academy of Sciences, , March 17. Ankara
PY  - 2020
SN  - 03779777 (ISSN)
SP  - 269-280
ST  - Contact tracing management of the COVID-19 pandemic
T2  - Turk Hijyen ve Deneysel Biyoloji Dergisi
TI  - Contact tracing management of the COVID-19 pandemic
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091723408&doi=10.5505%2fTurkHijyen.2020.80688&partnerID=40&md5=7dbe6cd17aa7c24636108467644e572b
VL  - 77
ID  - 7783248
ER  - 

TY  - JOUR
AB  - The ongoing SARS-CoV-2 pandemic stresses the need for effective antiviral drugs that can quickly be applied in order to reduce morbidity, mortality and ideally viral transmission. By repurposing of broadly active antiviral drugs and compounds that are known to inhibit viral replication of related viruses several advances could be made in the development of treatment strategies against COVID-19. The nucleoside analog remdesivir, which is known for its potent in vitro activity against Ebolavirus and other RNA viruses was recently shown to reduce the time to recovery in patients with severe COVID-19. It is to date the only approved antiviral for treating COVID-19. Here, we provide a mechanism and evidence based comparative review of remdesivir and other repurposed drugs with proven in vitro activity against SARS-CoV-2.
AD  - Department I of Internal Medicine, Division of Infectious Diseases, University of Cologne, 50937, Cologne, Germany.
Faculty of Medicine, Center for Molecular Medicine Cologne (CMMC), University of Cologne, 50931, Cologne, Germany.
German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany.
AN  - 33015938
AU  - Simonis, A.
AU  - Theobald, S. J.
AU  - Fätkenheuer, G.
AU  - Rybniker, J.
AU  - Malin, J. J.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.15252/emmm.202013105
DP  - NLM
ET  - 2020/10/06
J2  - EMBO molecular medicine
KW  - Covid-19
Remdesivir
SARS-CoV-2
antivirals
LA  - eng
N1  - 1757-4684
Simonis, Alexander
Theobald, Sebastian J
Fätkenheuer, Gerd
Rybniker, Jan
Malin, Jakob J
Journal Article
Review
England
EMBO Mol Med. 2020 Oct 4:e202013105. doi: 10.15252/emmm.202013105.
PY  - 2020
SN  - 1757-4676
SP  - e202013105
ST  - A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2
T2  - EMBO molecular medicine
TI  - A comparative analysis of remdesivir and other repurposed antivirals against SARS-CoV-2
ID  - 7785234
ER  - 

TY  - JOUR
AB  - OBJECTIVES: We evaluated whether implementation of lockdown orders in South Africa affected ambulatory clinic visitation in rural Kwa-Zulu Natal (KZN). DESIGN: Observational cohort SETTING: Data were analysed from 11 primary healthcare clinics in northern KZN. PARTICIPANTS: A total of 46�?23 individuals made 89�?76 clinic visits during the observation period. EXPOSURE OF INTEREST: We conducted an interrupted time series analysis to estimate changes in clinic visitation with a focus on transitions from the prelockdown to the level 5, 4 and 3 lockdown periods. OUTCOME MEASURES: Daily clinic visitation at ambulatory clinics. In stratified analyses, we assessed visitation for the following subcategories: child health, perinatal care and family planning, HIV services, non-communicable diseases and by age and sex strata. RESULTS: We found no change in total clinic visits/clinic/day at the time of implementation of the level 5 lockdown (change from 90.3 to 84.6 mean visits/clinic/day, 95% CI -16.5 to 3.1), or at the transitions to less stringent level 4 and 3 lockdown levels. We did detect a 50% reduction in child healthcare visits at the start of the level 5 lockdown from 11.9 to 4.7 visits/day (-7.1 visits/clinic/day, 95% CI -8.9 to 5.3), both for children aged 1 year and 1-5 years, with a gradual return to prelockdown within 3 months after the first lockdown measure. In contrast, we found no drop in clinic visitation in adults at the start of the level 5 lockdown, or related to HIV care (from 37.5 to 45.6, 8.0 visits/clinic/day, 95% CI 2.1 to 13.8). CONCLUSIONS: In rural KZN, we identified a significant, although temporary, reduction in child healthcare visitation but general resilience of adult ambulatory care provision during the first 4 months of the lockdown. Future work should explore the impacts of the circulating epidemic on primary care provision and long-term impacts of reduced child visitation on outcomes in the region.
AD  - Clinical Research Department, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa mark.siedner@ahri.org.
Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Department of Health Systems Administration, Georgetown University, Washington, District of Columbia, USA.
Department of Mathematics and Statistics, Georgetown University, Washington, District of Columbia, USA.
Institute for Global Health, University College London, London, UK.
Department of Social Sciences, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Department of Population Research, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Department of Nursing, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Research Data Management, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Public Engagement, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Research Unit on AIDS, Medical Research Council and Ugandan Virus Research Institute, Entebbe, Uganda.
Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Clinical Research Department, Africa Health Research Institute, Durban, Kwa-Zulu Natal, South Africa.
Department of Sexual Health and HIV Medicine, Brighton and Sussex Medical School, Brighton, Brighton and Hove, UK.
AN  - 33020109
AU  - Siedner, M. J.
AU  - Kraemer, J. D.
AU  - Meyer, M. J.
AU  - Harling, G.
AU  - Mngomezulu, T.
AU  - Gabela, P.
AU  - Dlamini, S.
AU  - Gareta, D.
AU  - Majozi, N.
AU  - Ngwenya, N.
AU  - Seeley, J.
AU  - Wong, E.
AU  - Iwuji, C.
AU  - Shahmanesh, M.
AU  - Hanekom, W.
AU  - Herbst, K.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/bmjopen-2020-043763
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - BMJ open
KW  - Covid-19
international health services
public health
LA  - eng
N1  - 2044-6055
Siedner, Mark J
Orcid: 0000-0003-3506-842x
Kraemer, John D
Meyer, Mark J
Orcid: 0000-0003-3942-9675
Harling, Guy
Orcid: 0000-0001-6604-491x
Mngomezulu, Thobeka
Gabela, Patrick
Dlamini, Siphephelo
Gareta, Dickman
Majozi, Nomathamsanqa
Ngwenya, Nothando
Seeley, Janet
Orcid: 0000-0002-0583-5272
Wong, Emily
Iwuji, Collins
Shahmanesh, Maryam
Hanekom, Willem
Herbst, Kobus
Journal Article
England
BMJ Open. 2020 Oct 5;10(10):e043763. doi: 10.1136/bmjopen-2020-043763.
PY  - 2020
SN  - 2044-6055
SP  - e043763
ST  - Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: an interrupted time series analysis
T2  - BMJ open
TI  - Access to primary healthcare during lockdown measures for COVID-19 in rural South Africa: an interrupted time series analysis
VL  - 10
ID  - 7785053
ER  - 

TY  - JOUR
AB  - Prioritizing trainee safety during the COVID-19 era is paramount In March 2020, the AAMC recommended prohibiting medical students from direct patient care in significantly affected regions Guidelines continue evolving;however, the AMA continues to recommend clinical experiences, not requiring direct patient care, be achieved through virtual formats
AU  - Shibata, Jacqueline
AU  - Weingrow, Daniel
AU  - Tabibnia, Amir
AU  - Lim, George
AU  - Chiem, Alan
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Ultrasound Treasure Hunt: A Novel Teaching Method that Overcomes Direct-Patient Care Restrictions brought on by the COVID-19 Pandemic
T2  - AEM Education and Training
TI  - Ultrasound Treasure Hunt: A Novel Teaching Method that Overcomes Direct-Patient Care Restrictions brought on by the COVID-19 Pandemic
UR  - https://doi.org/10.1002/aet2.10541
ID  - 7788132
ER  - 

TY  - JOUR
AB  - In this current pandemic of COVID-19, entire world is facing a huge crisis in healthcare and economic fronts. Till date, there is no definitive drug or vaccine for the cure of this novel Coronavirus 2019. Numerous repurposed and newer drugs are being tried in the therapy of this disease yet none have reached to conclusion of effectiveness in this disease. Hence, preventive strategies like social distancing, hand washing, using hand sanitizers, masks and personal protective equipment tends to be the crucial component in prevention from getting infected from this highly infective virus. Alcohol based hand sanitizers and hand rubs with more than 70 % alcohol seems to be effective in disinfecting the hands and touched surfaces. The sanitizers seem to be the first line of defense in the prevention of COVID19 as well as other microbial infections. The article elaborates the importance of hand sanitizers in the present new world pandemic and reduction in disease burden. Copyright © 2020, Global Research Online. All rights reserved.
AD  - (Sharma, Dutta, Kumar, Singh) Department of Pharmacology, All India Institute of Medical Sciences (AIIMS), Jodhpur, Rajasthan 342005, India (Sharma) Dr.V.M. Govt. Medical College, Solapur, Maharashtra 403001, India
A. Sharma, Dr.V.M. Govt. Medical College, Solapur, Maharashtra 403001, India. E-mail: dranusharma2014@gmail.com
AN  - 2005146636
AU  - Sharma, R. P.
AU  - Dutta, S.
AU  - Kumar, T.
AU  - Singh, S.
AU  - Sharma, A.
C1  - 10/6/2020
DA  - September-October
DB  - Embase
DO  - http://dx.doi.org/10.47583/ijpsrr.2020.v64i01.032
DP  - Ovid Technologies
IS  - 1
KW  - Alcohol Base Hand Rub
Coronavirus
covid-19
Hand sanitizer
Micro-organism
SARS-CoV-2
article
coronavirus disease 2019
disease burden
hand washing
human
mask
microorganism
nonhuman
pandemic
prevention
protective equipment
social distancing
alcohol
vaccine
LA  - English
PY  - 2020
SN  - 0976-044X
SP  - 179-182
ST  - Role of alcohol based hand rubs (ABHR) in the COVID-19 era: A concise review
T2  - International Journal of Pharmaceutical Sciences Review and Research
TI  - Role of alcohol based hand rubs (ABHR) in the COVID-19 era: A concise review
UR  - http://globalresearchonline.net/journalcontents/v64-1/32.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005146636
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.47583%2Fijpsrr.2020.v64i01.032&issn=0976-044X&isbn=&volume=64&issue=1&spage=179&pages=179-182&date=2020&title=International+Journal+of+Pharmaceutical+Sciences+Review+and+Research&atitle=Role+of+alcohol+based+hand+rubs+%28ABHR%29+in+the+COVID-19+era%3A+A+concise+review&aulast=Sharma&pid=%3Cauthor%3ESharma+R.P.%2CDutta+S.%2CKumar+T.%2CSingh+S.%2CSharma+A.%3C%2Fauthor%3E&%3CAN%3E2005146636%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 64
ID  - 7782993
ER  - 

TY  - JOUR
AB  - BackgroundWe aimed to systematically review all relevant studies related to the risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients.MethodsWe utilised PubMed, Scopus, ProQuest, Wiley Online Library, ScienceDirect and MedRxiv to search for studies, with additional hand-searched journals. We included systematic reviews/meta-analyses, cohort and case control studies of suspected and/or confirmed COVID-19 cases with severe illness and/or mortality as outcomes. We included laboratory test results and risk factors. We assessed risk of bias using ROBIS-I and Newcastle-Ottawa Scale assessment tool. Type of study, risk of bias, and precision of results determined evidence sufficiency.ResultsOf 26 records included, sufficient evidence suggested the association between age 60 years, hypertension, coronary heart disease, DM, serum LDH 250-500 U/L, LDH 500 U/L, and lymphopenia (lymphocyte count �?.0 x 109 /L) and severe illness of COVID-19. CD3+CD8+ cell count �?75 cell/μl, D-dimer  1 mg/L, AKI stage 2 and 3, proteinuria �?+, hematuria �?+, and peak serum creatinine  13.26 μmol/L are associated with mortality.ConclusionAge 60 years, hypertension, DM, and coronary heart disease are the risk factors for severe illness of COVID-19. Laboratory test results associated with severe illness are serum LDH 250-500 U/L, LDH 500 U/L, and lymphopenia, whereas test results associated with mortality are CD3+CD8+ cell count �?75 cell/μl, AKI stage 2 and 3, proteinuria �?+, hematuria �?+, D-dimer  1 mg/L, peak serum creatinine  13.26 μmol/L.
AD  - 1 Clinical Epidemiology and Evidence-Based Medicine Unit, Cipto Mangunkusumo Hospital - Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia 2 Division of Geriatrics, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia -Cipto Mangunkusumo Hospital, Jakarta, Indonesia. s_setiati@yahoo.com.
AN  - 33020334
AU  - Setiati, S.
AU  - Harimurti, K.
AU  - Safitri, E. D.
AU  - Ranakusuma, R. W.
AU  - Saldi, S. R. F.
AU  - Azwar, M. K.
AU  - Marsigit, J.
AU  - Pitoyo, Y.
AU  - Widyaningsih, W.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
laboratory test
mortality
risk factor
severe illness
LA  - eng
N1  - Setiati, Siti
Harimurti, Kuntjoro
Safitri, Eka Dian
Ranakusuma, Respati W
Saldi, Siti Rizny F
Azwar, Muhammad K
Marsigit, Jessica
Pitoyo, Yupitri
Widyaningsih, Widyaningsih
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):227-245.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 227-245
ST  - Risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients: A systematic review
T2  - Acta medica Indonesiana
TI  - Risk factors and laboratory test results associated with severe illness and mortality in COVID-19 patients: A systematic review
VL  - 52
ID  - 7785034
ER  - 

TY  - JOUR
AB  - Since the detection of the first confirmed case of coronavirus disease 2019 (COVID-19) in early March 2020, 248,852 cases have been detected in Indonesia by 21 September 2020. At least 100 doctors have died from COVID-19 nationwide. Full large-scale social restriction was a temporary measure, followed by an early transition to the new normal era during the never-ending first wave in the country. Workers in industrial, retail, transport, and tourism fields suffered a significant decrease in work. Many countries are, however, in dilemma of protecting the health of the citizens and prioritising economy. Health should be prioritised because it is an important aspect of our lives for our economy. Poor health is estimated to reduce global gross domestic product (GDP) by 15% annually through premature deaths and potential loss of productivity of the working-age citizens. Pandemics also depress economy through decrease in both supply and demand. Data from flu pandemic a century ago suggested the importance of aggressiveness and speed of intervention. Taiwan's early action led to beneficial effects on SARS-CoV-2 infection rate and economy recovery. The target of enhancement of containment measures, provision of personal protective equipments, and testing and isolation facilities should be achieved earlier and be more than the projected demand.
AD  - Department of Internal Medicine - Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia. s_setiati@yahoo.com.
AN  - 33020330
AU  - Setiati, S.
AU  - Azwar, M. K.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
Dilemma
Economy
Health
Indonesia
LA  - eng
N1  - Setiati, Siti
Azwar, Muhammad K
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):196-198.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 196-198
ST  - Dilemma of Prioritising Health and the Economy During COVID-19 Pandemic in Indonesia
T2  - Acta medica Indonesiana
TI  - Dilemma of Prioritising Health and the Economy During COVID-19 Pandemic in Indonesia
VL  - 52
ID  - 7785038
ER  - 

TY  - JOUR
AB  - Rapid obtaining of safe, effective, anti-viral vaccines has recently risen to the top of the international agenda. To maximize the success probability of future anti-viral vaccines, the anti-viral vaccines successful in the past are summarized here by virus type and vaccine type. The primary focus is on viruses with both single-stranded RNA genomes and a membrane envelope, given the pandemic past of influenza viruses and coronaviruses. The following conclusion is reached, assuming that success of future strategies is positively correlated with strategies successful in the past. The primary strategy, especially for emerging pandemic viruses, should be development of vaccine antigens that are live-attenuated viruses; the secondary strategy should be development of vaccine antigens that are inactivated virus particles. Support for this conclusion comes from the complexity of immune systems. These conclusions imply the need for a revision in current strategic planning.
AD  - Department of Biochemistry and Structural Biology, The University of Texas Health Center, San Antonio, TX 78229-3900, USA.
AN  - 33019507
AU  - Serwer, P.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/vaccines8040566
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Vaccines
KW  - SARS-CoV-2
immune system complexity
influenza
pandemics, virus-caused
vaccine development strategy
LA  - eng
N1  - Serwer, Philip
Orcid: 0000-0002-8990-3251
2018/San Antonio Area Foundation/
2019/Morrison Trust/
Journal Article
Switzerland
Vaccines (Basel). 2020 Oct 1;8(4):E566. doi: 10.3390/vaccines8040566.
PY  - 2020
SN  - 2076-393X (Print)
2076-393x
ST  - Using the Past to Maximize the Success Probability of Future Anti-Viral Vaccines
T2  - Vaccines
TI  - Using the Past to Maximize the Success Probability of Future Anti-Viral Vaccines
VL  - 8
ID  - 7785099
ER  - 

TY  - JOUR
AB  - On March 11th, 2020, the World Health Organization declared COVID-19 infection as a pandemic. Since it is a novel virus, there are basically no proven drugs or therapies; although many laboratories in different countries are working to develop a vaccine, it will take time to make it available. Passive immunization is the therapy born from the intuition of Behring and Kisato in the late 19th century. It was widely used for the treatment of bacterial infections until the discovery of antibiotics, as well as during the viral pandemics of the 20th century and of the beginning of the 21st; it still has clinical applications (e.g., tetanus prevention). This paper summarizes the basic principles of passive immunization, with particular reference to convalescent plasma. The literature concerning its use during past epidemics and the results of the first clinical studies concerning its use during the current pandemic are discussed too. A large section is dedicated to the analysis of the possible, although rare, side effects. Recently, in 2017, the WHO Blood Regulators Network (BRN) published a position paper, recommending convalescent plasma as the first-choice treatment to be tested in the absence of authorized drugs; however, this strategy has not been followed. In the current epidemic, the principle of passive immunization through convalescent plasma has been applied in several circumstances and particularly in patients with serious complications. The first reported results are encouraging and confirm the effectiveness of plasma therapy and its safety. Also, the FDA has proposed plasma treatment in order to face the increasingly complex situation and manage patients with serious or immediately life-threatening COVID-19 disease. Several studies and clinical programs are still ongoing.
AD  - Department of Experimental and Clinical Biomedical Sciences Radiodiagnostic Unit N. 2, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy ; Department of Experimental and Clinical Biomedical Sciences Radiodiagnostic Unit N. 2, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50134 Florence, Italy
AN  - 2448264192
AU  - Selvi, Valeria
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/2606058
DP  - ProQuest Central
KW  - Medical Sciences
Epidemics
Pandemics
Side effects
Bacterial diseases
Vaccines
Immunization (passive)
Mortality
Regulators
Complications
Viruses
Antibiotics
COVID-19
Health services
Viral diseases
Immunization
Tetanus
Infections
Patients
Coronaviruses
China
LA  - English
N1  - Copyright - Copyright © 2020 Valeria Selvi. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
SubjectsTermNotLitGenreText - China
PY  - 2020
SN  - 23146133
ST  - Convalescent Plasma: A Challenging Tool to Treat COVID-19 Patients—A Lesson from the Past and New Perspectives
T2  - BioMed Research International
TI  - Convalescent Plasma: A Challenging Tool to Treat COVID-19 Patients—A Lesson from the Past and New Perspectives
UR  - https://www.proquest.com/docview/2448264192?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Convalescent+Plasma%3A+A+Challenging+Tool+to+Treat+COVID-19+Patients%26mdash%3BA+Lesson+from+the+Past+and+New+Perspectives&title=BioMed+Research+International&issn=23146133&date=2020-01-01&volume=2020&issue=&spage=&au=Selvi%2C+Valeria&isbn=&jtitle=BioMed+Research+International&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F2606058
VL  - 2020
ID  - 7784934
ER  - 

TY  - JOUR
AU  - Sekhar, Jerin C.
AU  - Passi, Gouri Rao
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A game changer in COVID-19 testing
T2  - Indian Pediatrics
TI  - A game changer in COVID-19 testing
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812931
ID  - 7788118
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To determine whether SARS-CoV-2 is present in the vaginal secretions of both reproductive-aged and postmenopausal women during acute SARS-CoV-2 infection. DESIGN: Prospective study. SETTING: a single tertiary, university-affiliated medical center in Israel. Time period, June 1, 2020 through July 31, 2020. POPULATION: Women that were hospitalized in a single tertiary medical center, who were diagnosed with acute SARS-CoV-2 infection by a nasopharyngeal RT-PCR test. METHODS: A prospective study of women who were diagnosed with acute SARS-CoV-2 infection by a nasopharyngeal RT-PCR test. Vaginal RT-PCR swabs were obtained from all study participants after a proper cleansing of the perineum. MAIN OUTCOME MEASURES: Detection of SARS-CoV-2 in vaginal RT-PCR swabs. RESULTS: Vaginal and nasopharyngeal swabs were obtained from 35 women, aged 21-93 years. Twenty-one patients (60%) were in their reproductive years, of them, 5 patients were in their third trimester of pregnancy. Most of the participants (57%) were healthy without any underlying medical conditions. Of the 35 patients sampled, 2 (5.7%) had a positive vaginal RT-PCR for SARS-CoV-2, one was pre-menopausal and the other was a post-menopausal woman. Both women had mild disease. CONCLUSION: Our findings contradict most previous reports, which did not detect the presence of viral colonization in the vagina. Although passage through the birth canal exposes neonates to the vaginal polymicrobial flora, an acquisition of pathogens does not necessarily mandate neonatal infection or clinical disease. Nevertheless, when delivering a woman with acute SARS-CoV-2 infection, a clinician should consider the possibility of vaginal colonization, even if it is uncommon.
AD  - Department of Obstetrics and Gynecology, Lis Maternity Hospital, Sourasky Medical Center, Tel Aviv, Israel, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Maccabi Healthcare Services, Herzliya, Israel.
AN  - 33021026
AU  - Schwartz, A.
AU  - Yogev, Y.
AU  - Zilberman, A.
AU  - Alpern, S.
AU  - Many, A.
AU  - Yousovich, R.
AU  - Gamzu, R.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/1471-0528.16556
DP  - NLM
ET  - 2020/10/07
J2  - BJOG : an international journal of obstetrics and gynaecology
KW  - SARS-CoV-2
Vaginal secretion
LA  - eng
N1  - 1471-0528
Schwartz, Anat
Orcid: 0000-0002-0161-8932
Yogev, Yariv
Zilberman, Ayala
Alpern, Sharon
Many, Ariel
Yousovich, Ruth
Gamzu, Ronni
Journal Article
England
BJOG. 2020 Oct 5. doi: 10.1111/1471-0528.16556.
PY  - 2020
SN  - 1470-0328
ST  - Detection of SARS-CoV-2 in vaginal swabs of women with acute SARS-CoV-2 infection: a prospective study
T2  - BJOG : an international journal of obstetrics and gynaecology
TI  - Detection of SARS-CoV-2 in vaginal swabs of women with acute SARS-CoV-2 infection: a prospective study
ID  - 7784962
ER  - 

TY  - JOUR
AB  - ZusammenfassungDie durch SARS‐CoV�? verursachte Pandemie COVID�?9 hat weitreichende direkte und indirekte medizinische Folgen. Dazu gehören sowohl der Verlauf als auch die Behandlung vieler Krankheiten. Es wird immer deutlicher, dass Infektionen mit SARS‐CoV�? erhebliche immunologische Veränderungen verursachen können, die insbesondere auch pathogenetisch und/oder therapeutisch relevante Faktoren betreffen.Vor diesem Hintergrund fassen wir hier den aktuellen Wissensstand zur Interaktion von SARS‐CoV�?/COVID�?9 mit Mediatoren der akuten Phase der Entzündung (TNF, IL�?, IL�?), der Typ�?�?und Typ�?7‐Immunantwort (IL�?2, IL�?3, IL�?7, IL�?6), Typ�?‐Immunreaktionen (IL�?, IL�?3, IL�?, IL�?1, IgE), B‐Zell‐Immunität, Checkpoint‐Regulatoren (PD�?, PD‐L1, CTLA4) und Signalwegen, die durch oral applizierte Medikamente moduliert werden (JAK, PDE4, Calcineurin), zusammen. Darüber hinaus diskutieren wir in diesem Zusammenhang die unspezifische Immunmodulation durch Glukokortikosteroide, Methotrexat, Malariamittel, Azathioprin, Dapson, Mycophenolsäure‐Derivate und Fumarsäureester sowie angeborene Immunmechanismen neutrophiler Granulozyten.Aus diesen neueren Erkenntnissen leiten wir mögliche Implikationen für die therapeutische Modulation der genannten immunologischen Mechanismen im Zusammenhang mit SARS‐CoV�?/COVID�?9 ab. Obwohl natürlich bei Patienten mit immunologisch vermittelten Krankheiten oder immunmodulierenden Therapien größte Vorsicht geboten ist, scheint es, dass viele Behandlungen auch während der COVID�?9‐Pandemie durchgeführt werden können; einige scheinen COVID�?9 sogar zu lindern.
AD  - Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Deutschland; Niedersächsisches Institut für Berufsdermatologie, Universitätsmedizin Göttingen, Deutschland ; Hautklinik, Universitätsklinikum Erlangen, Deutsches Zentrum Immuntherapie, Friedrich‐Alexander‐Universität Erlangen‐Nürnberg, Deutschland ; Klinik für Dermatologie und Allergie Biederstein, Technische Universität München, Deutschland ; Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Deutschland ; Klinik für Dermatologie und Allergie Biederstein, Technische Universität München, Deutschland; Department of Medicine Solna, Unit of Dermatology and Venereology, Karolinska Institutet, Stockholm, Schweden ; ZAUM �?Zentrum für Allergie und Umwelt, Technische Universität München, Deutschland ; Klinik für Dermatologie, Venerologie und Allergologie, Charité �?Universitätsmedizin Berlin, Deutschland ; Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Deutschland ; Lübeck Institut für Experimentelle Dermatologie, Universität Lübeck, Deutschland ; Hautklinik, Universitätsklinikum Heidelberg, Deutschland ; Klinik für Dermatologie, Inselspital Universitätsklinikum Bern, Schweiz ; Klinik für Dermatologie, Medizinische Universität Wien, Österreich ; Klinik für Dermatologie, Universitätsklinikum Köln, Deutschland ; Klinik für Dermatologie, Westfälische Wilhelms‐Universität Münster, Deutschland ; Klinik für Dermatologie, Venerologie und Allergologie, Universitätsmedizin Göttingen, Deutschland; Niedersächsisches Institut für Berufsdermatologie, Universitätsmedizin Göttingen, Deutschland
AN  - 2448415518
AU  - Schön, Michael P.
AU  - Berking, Carola
AU  - Biedermann, Tilo
AU  - Buhl, Timo
AU  - Erpenbeck, Luise
AU  - Eyerich, Kilian
AU  - Eyerich, Stefanie
AU  - Ghoreschi, Kamran
AU  - Goebeler, Matthias
AU  - Ludwig, Ralf J.
AU  - Schäkel, Knut
AU  - Schilling, Bastian
AU  - Schlapbach, Christoph
AU  - Stary, Georg
AU  - Esther von, Stebut
AU  - Steinbrink, Kerstin
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/ddg.14169_g
DP  - ProQuest Central
IS  - 8
KW  - Medical Sciences--Dermatology And Venereology
Severe acute respiratory syndrome coronavirus 2
Immunoglobulin E
COVID-19
CTLA-4 protein
Calcineurin
Tumor necrosis factor
Phosphodiesterase
LA  - English
N1  - Copyright - © 2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SN  - 16100379
SP  - 795-809
ST  - COVID�?9 und Immunregulation �?von grundlegenden und translationalen Aspekten zu klinischen Implikationen
T2  - Journal der Deutschen Dermatologischen Gesellschaft
TI  - COVID�?9 und Immunregulation �?von grundlegenden und translationalen Aspekten zu klinischen Implikationen
UR  - https://www.proquest.com/docview/2448415518?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=COVID%E2%80%9019+und+Immunregulation+%26ndash%3B+von+grundlegenden+und+translationalen+Aspekten+zu+klinischen+Implikationen&title=Journal+der+Deutschen+Dermatologischen+Gesellschaft&issn=16100379&date=2020-08-01&volume=18&issue=8&spage=795&au=Sch%C3%B6n%2C+Michael+P%3BBerking%2C+Carola%3BBiedermann%2C+Tilo%3BBuhl%2C+Timo%3BErpenbeck%2C+Luise%3BEyerich%2C+Kilian%3BEyerich%2C+Stefanie%3BGhoreschi%2C+Kamran%3BGoebeler%2C+Matthias%3BLudwig%2C+Ralf+J%3BSch%C3%A4kel%2C+Knut%3BSchilling%2C+Bastian%3BSchlapbach%2C+Christoph%3BStary%2C+Georg%3BEsther+von+Stebut%3BSteinbrink%2C+Kerstin&isbn=&jtitle=Journal+der+Deutschen+Dermatologischen+Gesellschaft&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fddg.14169_g
VL  - 18
ID  - 7784909
ER  - 

TY  - JOUR
AB  - The COVID�?9 pandemic caused by SARS‐CoV�? has far‐reaching direct and indirect medical consequences. These include both the course and treatment of diseases. It is becoming increasingly clear that infections with SARS‐CoV�? can cause considerable immunological alterations, which particularly also affect pathogenetically and/or therapeutically relevant factors.Against this background we summarize here the current state of knowledge on the interaction of SARS‐CoV�?/COVID�?9 with mediators of the acute phase of inflammation (TNF, IL�?, IL�?), type 1 and type 17 immune responses (IL�?2, IL�?3, IL�?7, IL�?6), type 2 immune reactions (IL�?, IL�?3, IL�?, IL�?1, IgE), B‐cell immunity, checkpoint regulators (PD�?, PD‐L1, CTLA4), and orally druggable signaling pathways (JAK, PDE4, calcineurin). In addition, we discuss in this context non‐specific immune modulation by glucocorticosteroids, methotrexate, antimalarial drugs, azathioprine, dapsone, mycophenolate mofetil and fumaric acid esters, as well as neutrophil granulocyte‐mediated innate immune mechanisms.From these recent findings we derive possible implications for the therapeutic modulation of said immunological mechanisms in connection with SARS‐CoV�?/COVID�?9. Although, of course, the greatest care should be taken with patients with immunologically mediated diseases or immunomodulating therapies, it appears that many treatments can also be carried out during the COVID�?9 pandemic; some even appear to alleviate COVID�?9.
AD  - Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany; Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen, Germany ; Department of Dermatology, University Medical Center Erlangen, Deutsches Zentrum Immuntherapie, Friedrich Alexander University Erlangen‐Nürnberg, Germany ; Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany ; Department of Dermatology and Allergy Biederstein, Technical University Munich, Germany; Department of Medicine Solna, Unit of Dermatology and Venereology, Karolinska Institutet, Stockholm, Sweden ; ZAUM �?Center of Allergy and Environment, Technical University and Helmholtz Center Munich, Germany ; Department of Dermatology, Venereology and Allergology, Charité �?University Medical Center Berlin, Germany ; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany ; Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany ; Department of Dermatology, University Medical Center Heidelberg, Germany ; Department of Dermatology, Inselspital University Medical Center, Bern, Switzerland ; Department of Dermatology, Medical University of Vienna, Austria ; Department of Dermatology, University Hospital Cologne, Germany ; Department of Dermatology, Westfälische Wilhelms University Münster, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany; Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen, Germany
AN  - 2448415652
AU  - Schön, Michael P.
AU  - Berking, Carola
AU  - Biedermann, Tilo
AU  - Buhl, Timo
AU  - Erpenbeck, Luise
AU  - Eyerich, Kilian
AU  - Eyerich, Stefanie
AU  - Ghoreschi, Kamran
AU  - Goebeler, Matthias
AU  - Ludwig, Ralf J.
AU  - Schäkel, Knut
AU  - Schilling, Bastian
AU  - Schlapbach, Christoph
AU  - Stary, Georg
AU  - Esther von, Stebut
AU  - Steinbrink, Kerstin
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/ddg.14169
DP  - ProQuest Central
IS  - 8
KW  - Medical Sciences--Dermatology And Venereology
Esters
CTLA-4 protein
Calcineurin
Methotrexate
Phosphodiesterase
Dapsone
Mycophenolate mofetil
Pandemics
Immunology
Mycophenolic acid
Immunomodulation
Severe acute respiratory syndrome coronavirus 2
Immunoglobulin E
Immunosuppressive agents
COVID-19
Azathioprine
Tumor necrosis factor
Leukocytes (granulocytic)
Immune response
Fumaric acid
LA  - English
N1  - Copyright - © 2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SN  - 16100379
SP  - 795-807
ST  - COVID�?9 and immunological regulations �?from basic and translational aspects to clinical implications
T2  - Journal der Deutschen Dermatologischen Gesellschaft
TI  - COVID�?9 and immunological regulations �?from basic and translational aspects to clinical implications
UR  - https://www.proquest.com/docview/2448415652?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=COVID%E2%80%9019+and+immunological+regulations+%26ndash%3B+from+basic+and+translational+aspects+to+clinical+implications&title=Journal+der+Deutschen+Dermatologischen+Gesellschaft&issn=16100379&date=2020-08-01&volume=18&issue=8&spage=795&au=Sch%C3%B6n%2C+Michael+P%3BBerking%2C+Carola%3BBiedermann%2C+Tilo%3BBuhl%2C+Timo%3BErpenbeck%2C+Luise%3BEyerich%2C+Kilian%3BEyerich%2C+Stefanie%3BGhoreschi%2C+Kamran%3BGoebeler%2C+Matthias%3BLudwig%2C+Ralf+J%3BSch%C3%A4kel%2C+Knut%3BSchilling%2C+Bastian%3BSchlapbach%2C+Christoph%3BStary%2C+Georg%3BEsther+von+Stebut%3BSteinbrink%2C+Kerstin&isbn=&jtitle=Journal+der+Deutschen+Dermatologischen+Gesellschaft&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fddg.14169
VL  - 18
ID  - 7784906
ER  - 

TY  - JOUR
AD  - University of Pennsylvania, Philadelphia, PA.
Massachusetts Institute of Technology, Cambridge, MA.
Boston College, Chestnut Hill, MA.
AN  - 33020072
AU  - Schmidt, H.
AU  - Pathak, P.
AU  - Sönmez, T.
AU  - Ünver, M. U.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/bmj.m3795
DP  - NLM
ET  - 2020/10/07
J2  - BMJ (Clinical research ed.)
LA  - eng
N1  - 1756-1833
Schmidt, Harald
Pathak, Parag
Sönmez, Tayfun
Ünver, M Utku
Journal Article
England
BMJ. 2020 Oct 5;371:m3795. doi: 10.1136/bmj.m3795.
PY  - 2020
SN  - 0959-8138
SP  - m3795
ST  - Covid-19: how to prioritize worse-off populations in allocating safe and effective vaccines
T2  - BMJ 
TI  - Covid-19: how to prioritize worse-off populations in allocating safe and effective vaccines
VL  - 371
ID  - 7785055
ER  - 

TY  - JOUR
AB  - We describe a rapid and reusable biophysical method to assay COVID-19. The method uses fluorescent sensors (i.e. molecular beacons) designed to detect COVID-19 RNA or any RNA of interest, concurrent with an internal control without the need for amplification. The molecular beacons are stem-loop structures in which a ~10 nucleotide loop region has the complementary sequence of a region of the target RNA, and a fluorophore and quencher are placed on the 5&#039; and 3&#039; ends of the stem. The energy of hybridization of the loop with its target is designed to be greater than the hybridization energy of the energy of the stem so that when the beacon encounters its target RNA, the structure opens resulting in dequenching of the fluorophore. Here, we designed a COVID-19 beacon that is completely quenched in its native form and undergoes a 50-fold increase in fluorescence when exposed to nanomolar amounts of synthetic viral oligonucleotide. No changes in intensity are seen when control RNA is added. A control beacon to a human GAPDH RNA, chosen for its high levels in saliva, behaved similar to the COVID-19 beacon. This increase in fluorescence with beacon opening can be completely reversed upon addition of single stranded DNA complementary to COVID-19 beacon loop region. Beacons can be attached to an insert matrix allowing their use in concentrated form and can be made from morphilino oligonucleotides that are resistant to RNases. We present an analysis of the parameters that will allow the development of test strips to detect virus in aerosol, body fluids and community waste.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialThis work was declared exempt from human subject research based on Worcester Polytechnic University&#039;s IRB review board.Funding StatementNIH-NIGMSAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Human Subjects Exemption was issued by the WPI Institutional Review Board, Chaired by Kent Rissmiller, PhD, JD All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll primary data will be available upon request
AU  - Scarlata, Suzanne
AU  - Yerramilli, V. Siddartha
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20196113
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20196113
ST  - Design Of A Rapid And Reversible Fluorescence Assay To Detect COVID-19 And Other Pathogens (preprint)
T2  - medRxiv
TI  - Design Of A Rapid And Reversible Fluorescence Assay To Detect COVID-19 And Other Pathogens (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20196113.abstract
ID  - 7788888
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2. With the rapid evolution of the pandemic, even the off-label use of existing drugs has been restricted by limited availability. Several old antivirals, antimalarial, and biological drugs are being reconsidered as possible therapies. The effectiveness of the controversial treatment options for COVID-19 such as nonsteroidal antiinflammatory drugs, angiotensin 2 conversion enzyme inhibitors and selective angiotensin receptor blockers was also discussed. A systemic search in the PubMed, Science Direct, LitCovid, Chinese Clinical Trial Registry, and ClinicalTrials.gov data bases was conducted using the keywords "coronavirus drug therapy," passive immunotherapy for COVID-19', "convalescent plasma therapy," (CPT) "drugs for COVID-19 treatment," "SARS-CoV-2," "COVID-19," "2019-nCoV," "coronavirus immunology," "microbiology," "virology," and individual drug names. Systematic reviews, case presentations and very recent clinical guidelines were included. This narrative review summarizes the available information on possible therapies for COVID-19, providing recent data to health professionals. © Copyright © 2020 Sarkar, Mondal, Torequl Islam, Martorell, Docea, Maroyi, Sharifi-Rad and Calina.
AD  - (Sarkar, Mondal) Department of Pharmacy, Life Science School, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj (Dhaka), Bangladesh (Torequl Islam) Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Vietnam (Torequl Islam) Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam (Martorell) Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepcion, Concepcion, Chile (Martorell) Universidad de Concepcion, Unidad de Desarrollo Tecnologico, UDT, Concepcion, Chile (Docea) Department of Toxicology, University of Medicine and Pharmacy of Craiova, Craiova, Romania (Maroyi) Department of Botany, University of Fort Hare, Alice, South Africa (Sharifi-Rad) Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of (Calina) Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
M. Torequl Islam, Laboratory of Theoretical and Computational Biophysics, Ton Duc Thang University, Ho Chi Minh City, Vietnam M. Torequl Islam, Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam J. Sharifi-Rad, Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of D. Calina, Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Craiova, Romania
AN  - 632973757
AU  - Sarkar, C.
AU  - Mondal, M.
AU  - Torequl Islam, M.
AU  - Martorell, M.
AU  - Docea, A. O.
AU  - Maroyi, A.
AU  - Sharifi-Rad, J.
AU  - Calina, D.
C1  - 10/6/2020
DA  - 15 Sep
DB  - Embase
DO  - http://dx.doi.org/10.3389/fphar.2020.572870
DP  - Ovid Technologies
IS  - 572870
KW  - convalescent plasma
COVID-19 proposed therapy
pandemic
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
therapeutic challenges
clinical trial
coronavirus disease 2019
drug therapy
human
immunology
immunotherapy
Medline
narrative
practice guideline
review
ScienceDirect
systematic review
virology
angiotensin II
angiotensin receptor antagonist
enzyme inhibitor
nonsteroid antiinflammatory agent
LA  - English
M3  - Review
PY  - 2020
SN  - 1663-9812 (electronic)
1663-9812
ST  - Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives
T2  - Frontiers in Pharmacology
TI  - Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives
UR  - http://www.frontiersin.org/Pharmacology
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632973757
VL  - 11 (no pagination)
ID  - 7782918
ER  - 

TY  - JOUR
AB  - Background: Transmission dynamics of the infectious disease Corona Virus Disease - 19 (COVID-19) is yet to be understood fully The study aimed at exploring whether quantitative viral load of COVID-19-infected case indicated by cycle threshold (Ct) value of real-time reverse transcription polymerase chain reaction could predict about transmission pattern in the community Materials and Methods: An observational study was conducted involving 1976 individuals, suspected to be suffering from COVID-19 and contacts, of laboratory confirmed cases from selected districts of Gujarat, India A total of 138 persons were detected to be positive Weekly positivity showed an overall increasing trend during the studied weeks It was observed that only 7% had high, 9% as moderate and rest, 84% had low viral load based on Ct values of real-time RT-PCR Results: Most secondary cases clustered around index cases with high viral load whereas fewer secondary cases clustered around index cases with low viral load Each index high viral load case transmitted an average of 6 25 secondary cases whereas the same of low viral load transmitted an average of 0 8 case Conclusion: If cases with higher viral load are selectively isolated on detection from the rest of the community along with contact tracing of all individuals, who came in contact with them during the previous 5 days, the quantum of transmission will reduce subsequently Moreover, health-care workers often get infected while working, probably due to the fact that they often handle cases with higher viral load The Ct value of all may be provided along with test report to safeguard everybody&#039;s health including health-care workers
AU  - Sarkar, Bidisa
AU  - Sinha, Rabindra Nath
AU  - Sarkar, Kamalesh
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Initial viral load of a COVID-19-infected case indicated by its cycle threshold value of polymerase chain reaction could be used as a predictor of its transmissibility-An experience from Gujarat, India
T2  - Indian Journal of Community Medicine
TI  - Initial viral load of a COVID-19-infected case indicated by its cycle threshold value of polymerase chain reaction could be used as a predictor of its transmissibility-An experience from Gujarat, India
UR  - https://doi.org/10.4103/ijcm.IJCM_593_20
ID  - 7788394
ER  - 

TY  - JOUR
AU  - Sarbunan, Thobias
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - English Foreign Language, Deadly Boulevard, Third Circle, The Tentative Hypothesis, Novel Corona Virus Policy
PY  - 2020
ST  - Foreign Language Deadly Boulevard: The Tentative Hypothesis of Novel Corona Virus Policy Manifestation to the English as a Foreign Language (preprint)
T2  - SSRN
TI  - Foreign Language Deadly Boulevard: The Tentative Hypothesis of Novel Corona Virus Policy Manifestation to the English as a Foreign Language (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3694213
ID  - 7788902
ER  - 

TY  - JOUR
AB  - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes COVID-19 (Coronavirus disease 2019). This disease was detected in the city of Wuhan in China in December 2019. People infected with COVID-19 shows varying manifestations, depending on their health and age. The most common symptoms are fever, cough, myalgia, fatigue, odynophagia, and dyspnea. Infected adults older 60 years of age are the group of patients most susceptible to severe COVID-19 states and present comor-bidity in the presence of chronic diseases. On the other hand, it is also essential to have tests to detect SARS-COV-2 in people and follow the evolution of COVID-19 quickly, reliably, and cheap. To achieve this, there are real-time reverse transcription pol-ymerase chain reaction (RT-PCR) tests, isothermal nucleic acid amplification, and enzyme immunostimulation. Currently, there are no drug treatments to prevent infection and to combat the virus's effects. However, different research groups that are conduct-ing in vitro, in vivo, and in silico tests to find drugs able to provide an immune response and to control infection in humans with SARS-CoV-2. Chloroquine, hydroxychloroquine, remdesivir, interferon-�?b, and oseltamivir are some pharmacological options evaluated in clinical trials for prophylaxis of COVID-19. The purpose of this review is to establish a reference framework for taxonomic classification of SARS-CoV-2 and the relationship they have with other CoVs, as well as their structure and propaga-tion pathways in humans. The characteristics and symptoms presented by patients with COVID-19, the detection methods, and possible treatments are also presented.
AD  - Instituto de Agroindustrias, Universidad Tecnol�Qgica de la Mixteca, Huajuapan de Le�Qn, Oaxaca, México. ORCID: 0000-0001-5094-0488.
Instituto de Agroindustrias, Universidad Tecnol�Qgica de la Mixteca, Huajuapan de Le�Qn, Oaxaca, México. Direcci�Qn: km 2,5 Huajuapan de Le�Qn, Oaxaca, México, C�Qdigo postal: 69000. Email: rsalas@mixteco.utm.mx. ORCID: 0000-0002-5458-0157.
AN  - 33017386
AU  - Santos-S֙nchez, N. F.
AU  - Salas-Coronado, R.
C1  - 10/6/2020
DA  - Sep 25
DB  - PubMed
DO  - 10.5867/medwave.2020.08.8037
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Medwave
KW  - Antiviral agents
Mechanism of action
SARS-CoV-2
SARS-CoV-2 testing
Transmission
Betacoronavirus
LA  - spa
eng
N1  - 0717-6384
Santos-S֙nchez, Norma Francenia
Salas-Coronado, Raúl
Journal Article
Chile
Medwave. 2020 Sep 25;20(8):e8037. doi: 10.5867/medwave.2020.08.8037.
OP  - Origen, caracter�Tsticas estructurales, medidas de prevenci�Qn, diagn�Qstico y f֙rmacos potenciales para prevenir y controlar COVID-19.
PY  - 2020
SN  - 0717-6384
SP  - e8037
ST  - Origin, structural characteristics, prevention measures, diagnosis and potential drugs to prevent and COVID-19
T2  - Medwave
TI  - Origin, structural characteristics, prevention measures, diagnosis and potential drugs to prevent and COVID-19
VL  - 20
ID  - 7785137
ER  - 

TY  - JOUR
AB  - The recent COVID-19 pandemic promoted efforts to better understand the organization of the respiratory microbiome and its evolution from birth to adulthood and how it interacts with external pathogens and the host immune system. This review aims to deepen understanding of the essential physiological functions of the resident microbiome of the respiratory system on human health and diseases. First, the general characteristics of the normal microbiota in the different anatomical sites of the airways have been reported in relation to some factors such as the effect of age, diet and others on its composition and stability. Second, we analyze in detail the functions and composition and the correct functionality of the microbiome in the light of current knowledge. Several studies suggest the importance of preserving the micro-ecosystem of commensal, symbiotic and pathogenic microbes of the respiratory system, and, more recently, its relationship with the intestinal microbiome, and how it also leads to the maintenance of human health, has become better understood.
AD  - Ionian Department, Microbiology and Virology Laboratory, University of Bari "Aldo Moro", Piazza G. Cesare 11, 70124 Bari, Italy.
Department of Clinical Disciplines, University of Elbasan, Rruga Ismail Zyma, 3001 Elbasan, Albania.
Poison Center, OO. RR. University Hospital of Foggia, Viale Luigi Pinto 1, 71122 Foggia, Italy.
Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari "Aldo Moro", Via Orabona 4, 70125 Bari, Italy.
Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Vico L. De Crecchio 7, 80138 Naples, Italy.
Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza G. Cesare 11, 70124 Bari, Italy.
ENT Service, Brindisi Local Health Agency, Via Dalmazia 3, 72100 Brindisi, Italy.
Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari "Aldo Moro", Piazza G. Cesare 11, 70124 Bari, Italy.
AN  - 33019595
AU  - Santacroce, L.
AU  - Charitos, I. A.
AU  - Ballini, A.
AU  - Inchingolo, F.
AU  - Luperto, P.
AU  - De Nitto, E.
AU  - Topi, S.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/biology9100318
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Biology
KW  - SARS-CoV-2
asthma
clinical microbiology
dysbiosis
human microbiome
immune modulation
respiratory diseases
respiratory microbiome
translational research
LA  - eng
N1  - Santacroce, Luigi
Orcid: 0000-0001-5671-8124
Charitos, Ioannis Alexandros
Ballini, Andrea
Orcid: 0000-0001-8758-1415
Inchingolo, Francesco
Luperto, Paolo
De Nitto, Emanuele
Topi, Skender
Journal Article
Review
Switzerland
Biology (Basel). 2020 Oct 1;9(10):E318. doi: 10.3390/biology9100318.
PY  - 2020
SN  - 2079-7737 (Print)
2079-7737
ST  - The Human Respiratory System and its Microbiome at a Glimpse
T2  - Biology
TI  - The Human Respiratory System and its Microbiome at a Glimpse
VL  - 9
ID  - 7785094
ER  - 

TY  - JOUR
AB  - A 38-year-old man presented with cough, shortness of breath, and fatigue. He was diagnosed with Coronavirus Disease-2019 (COVID-19) as well as Enterococcus faecalis bacteremia. Imaging revealed a subaortic membrane with aortic valve endocarditis and severe aortic insufficiency. He had successful aortic valve replacement with a mechanical prosthesis and subaortic membrane resection. This case highlights some of the diagnostic and therapeutic challenges presented by COVID-19 pandemic.
AD  - Department of Internal Medicine, Section of Cardiology, Rush University Medical Center, Chicago, IL, USA.
Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, USA.
AN  - 33014475
AU  - Sanders, D. J.
AU  - Sutter, J. S.
AU  - Tatooles, A.
AU  - Suboc, T. M.
AU  - Rao, A. K.
C1  - 10/6/2020
C2  - PMC7525298
DB  - PubMed
DO  - 10.1155/2020/8844255
DP  - NLM
ET  - 2020/10/06
J2  - Case reports in cardiology
LA  - eng
N1  - 2090-6412
Sanders, David J
Orcid: 0000-0002-5050-4333
Sutter, Joanne S
Tatooles, Antone
Suboc, Tisha M
Rao, Anupama K
Case Reports
Case Rep Cardiol. 2020 Sep 29;2020:8844255. doi: 10.1155/2020/8844255. eCollection 2020.
PY  - 2020
SN  - 2090-6404 (Print)
2090-6404
SP  - 8844255
ST  - Endocarditis Complicated by Severe Aortic Insufficiency in a Patient with COVID-19: Diagnostic and Management Implications
T2  - Case reports in cardiology
TI  - Endocarditis Complicated by Severe Aortic Insufficiency in a Patient with COVID-19: Diagnostic and Management Implications
VL  - 2020
ID  - 7785395
ER  - 

TY  - JOUR
AB  - In view of the need to manage and forecast the number of Intensive Care Unit (ICU) beds for critically ill COVID-19 patients, the Forecast UTI open access application was developed to enable hospital indicator monitoring based on past health data and the temporal dynamics of the Coronavirus epidemic. Forecast UTI also enables short-term forecasts of the number of beds occupied daily by COVID-19 patients and possible care scenarios to be established. This article presents the functions, mode of access and examples of uses of Forecast UTI, a computational tool intended to assist managers of public and private hospitals within the Brazilian National Health System by supporting quick, strategic and efficient decision-making.
AU  - Salles Neto, Luiz Ledu�Tno de
AU  - Martins, Camila Bertini
AU  - Chaves, Antônio Augusto
AU  - Konstantyner, Thais Cl֙udia Roma de Oliveira
AU  - Yanasse, Horacio Hideki
AU  - Campos, Claudia Barbosa Ladeira de
AU  - Bellini, Ana Júlia de Oliveira
AU  - Butkeraites, Renan Brito
AU  - Correia, Leonardo
AU  - Magro, Igor Luciano
AU  - Soares, Fernando Dos Santos
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 4
LA  - pt
PY  - 2020
SP  - e2020391-e2020391
ST  - Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de COVID-19
T2  - Epidemiol Serv Saude
TI  - Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de COVID-19
TT  - Forecast UTI: aplicativo para previsão de leitos de unidades de terapia intensiva no contexto da pandemia de COVID-19.
Forecast UTI: application for predicting intensive care unit beds in the context of the COVID-19 pandemic.
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-809790
VL  - 29
ID  - 7788784
ER  - 

TY  - JOUR
AB  - The rate of venous and arterial thrombotic events among patients infected with severe acute respiratory syndrome coronavirus-2 (SAR-CoV-2) is high. This may be due to a hypercoagulable state induced by the severe inflammation that results from the SAR-CoV-2 infection. We aimed to determine hypercoagulable states' incidence based on thromboelastography study and its association with thrombotic events in critically ill patients with coronavirus disease 2019 (COVID-19). Fifty-two COVID-19 patients who had thromboelastography study were retrospectively included. All patients received pharmacologic thromboprophylaxis. The hypercoagulable state was observed in 16 patients (30.8%). Among them, maximum amplitude and a-angle were elevated in 75% and 25%, respectively. Reaction time and K were low in only 12.5% for both of them. Inflammatory and coagulation markers, as well as thromboprophylaxis regimens, were not associated with a hypercoagulable state. Fourteen patients (27%) experienced a total of 16 thrombotic events, including 8 (57%) deep venous thrombosis, 6 (43%) pulmonary embolism, and 2 (14.3%) arterial thrombosis. The hypercoagulable state was not significantly associated with thrombotic events. In summary, we observed a lower rate of hypercoagulable state on thromboelastography study in critically ill COVID-19 patients. Also, the hypercoagulable state was not associated with the occurrence of thrombotic events.
AD  - Department of Pharmacy, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Heart and Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.
Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. mallatjihad@gmail.com.
Critical Care Institute, Cleveland Clinic Abu Dhabi, Al Maryah Island, PO Box 112412, Abu Dhabi, United Arab Emirates. mallatjihad@gmail.com.
Normandy University, UNICAEN, ED 497, Caen, France. mallatjihad@gmail.com.
AN  - 33011896
AU  - Salem, N.
AU  - Atallah, B.
AU  - El Nekidy, W. S.
AU  - Sadik, Z. G.
AU  - Park, W. M.
AU  - Mallat, J.
C1  - 10/6/2020
C2  - PMC7532945
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s11239-020-02300-7
DP  - NLM
ET  - 2020/10/05
J2  - Journal of thrombosis and thrombolysis
KW  - Covid-19
Critically ill patients
Hypercoagulable state
Thromboelastography (TEG)
Thromboembolism
Thrombotic events
LA  - eng
N1  - 1573-742x
Salem, Nouran
Atallah, Bassam
El Nekidy, Wasim S
Sadik, Ziad G
Park, Woosup Michael
Mallat, Jihad
Orcid: 0000-0001-6372-7360
Letter
J Thromb Thrombolysis. 2020 Oct 4:1-5. doi: 10.1007/s11239-020-02300-7.
PY  - 2020
SN  - 0929-5305 (Print)
0929-5305
SP  - 1-5
ST  - Thromboelastography findings in critically ill COVID-19 patients
T2  - Journal of thrombosis and thrombolysis
TI  - Thromboelastography findings in critically ill COVID-19 patients
ID  - 7785646
ER  - 

TY  - JOUR
AB  - Telemedicine use among otolaryngologists-head and neck surgeons and facial plastic and reconstructive surgeons has accelerated as a result of the COVID-19 pandemic. Yet, it is unclear what impact the increased adoption of telehealth will have on the doctor-patient relationship, patients' perceptions of individual practices, and the likelihood of patients proceeding with the next steps toward surgery. While an understanding of these complex questions is imperative for all otolaryngologists, it is extremely important for facial plastic surgeons who focus on elective procedures, particularly cosmetic/aesthetic operations. The use of telemedicine has the potential to reduce bias among patients seeking facial plastic surgery, especially cosmetic procedures. As reports of this phenomenon are anecdotal thus far, we recommend further study into the specific criteria that patients consider when selecting a facial plastic surgeon.
AD  - Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, School of Medicine, Yale University, New Haven, Connecticut, USA.
Division of Facial Plastic and Reconstructive Surgery, Department of Otolaryngology-Head and Neck Surgery, University of California-Irvine, Irvine, California, USA.
Center for Advanced Facial Plastic Surgery, Beverly Hills, California, USA.
Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
AN  - 33019883
AU  - Salehi, P. P.
AU  - Wong, B. J. F.
AU  - Azizzadeh, B.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0194599820964731
DP  - NLM
ET  - 2020/10/07
J2  - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
KW  - Covid-19
SARS-CoV-2
bias
choosing surgeon
coronavirus
pandemic
patient bias
public health
surgeon selection
telehealth
telemedicine
virus
LA  - eng
N1  - 1097-6817
Salehi, Parsa P
Wong, Brian J F
Azizzadeh, Babak
Journal Article
England
Otolaryngol Head Neck Surg. 2020 Oct 6:194599820964731. doi: 10.1177/0194599820964731.
PY  - 2020
SN  - 0194-5998
SP  - 194599820964731
ST  - The Potential for Telemedicine to Reduce Bias in Patients Seeking Facial Plastic Surgery
T2  - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
TI  - The Potential for Telemedicine to Reduce Bias in Patients Seeking Facial Plastic Surgery
ID  - 7785077
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 remains a global threat with few proven efficacious treatments. Transfusion of convalescent plasma collected from donors who have recovered from COVID-19 disease has emerged as a promising therapy and has been granted emergency use authorization by the U.S. Food and Drug Administration (FDA). We recently reported results from interim analysis of a propensity-score matched study suggesting that early treatment of COVID-19 patients with convalescent plasma containing high titer anti-spike protein receptor binding domain (RBD) IgG significantly decreases mortality. We here present results from 60-day follow up of our cohort of 351 transfused hospitalized patients. Prospective determination of ELISA anti-RBD IgG titer facilitated selection and transfusion of the highest titer units available. Retrospective analysis by the Ortho VITROS IgG assay revealed a median signal/cutoff (S/C) ratio of 24.0 for transfused units, a value far exceeding the recently FDA-required cutoff of 12.0 for designation of high titer convalescent plasma. With respect to altering mortality, our analysis identified an optimal window of 44 hours post-hospitalization for transfusing COVID-19 patients with high titer convalescent plasma. In the aggregate, the analysis confirms and extends our previous preliminary finding that transfusion of COVID-19 patients soon after hospitalization with high titer anti-spike protein RBD IgG present in convalescent plasma significantly reduces mortality.Competing Interest StatementES is the local principal investigator for a clinical trial sponsored by Regeneron assessing an investigational therapy for COVID-19.Funding StatementThis study was supported by the Fondren Foundation, Houston Methodist Hospital and Research Institute (to JMM).Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Houston Methodist Research Institute ethics review boardAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesData available within the article or its supplementary materials.
AU  - Salazar, Eric
AU  - Christensen, Paul A.
AU  - Graviss, Edward A.
AU  - Ngyuen, Duc T.
AU  - Castillo, Brian
AU  - Chen, Jian
AU  - Valdez Lopez, Bevin
AU  - Eager, Todd
AU  - Yi, Xin
AU  - Zhao, Picheng
AU  - Rogers, John
AU  - Shehabeldin, Ahmed
AU  - Joseph, David
AU  - Masud, Faisal
AU  - Leveque, Christopher
AU  - Olsen, Randall J.
AU  - Bernard, David W.
AU  - Gollihar, Jimmy
AU  - Musser, James M.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20206029
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20206029
ST  - Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality (preprint)
T2  - medRxiv
TI  - Early transfusion of a large cohort of COVID-19 patients with high titer anti-SARS-CoV-2 spike protein IgG convalescent plasma confirms a signal of significantly decreased mortality (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20206029.abstract
ID  - 7788877
ER  - 

TY  - JOUR
AB  - Background: COVID-19 is a novel coronavirus, which is highly contagious and a threat to human health, spreading across nearly 235 countries, affecting 33.8 million and causing 1.01 million fatalities as of 22 September 2020. Researchers have invested tremendous efforts to develop vaccines or effective drug therapy but have not yet been fruitful. Hence, we planned to conduct this systematic review and meta-analysis to supplement the readers with comprehensive data and credible information on the safety and efficacyof essential pharmacotherapy during the pharmacological management of COVID-19. Methods: Theprotocol will be designed based on the updated PRISMA-P 2015 guidelines. An elaborate search of electronic databases such as PubMed/Medline, Web of Science, Scopus, The Cochrane Library, ClinicalTrials.gov, Google Scholar, Medrxiv and other potential databases for articles published during January 2020 to 10 October 2020 is planned to be conducted. Following this,randomized control trials published in English language that assess the safety and efficacy of pharmacotherapy versusplacebo or standard of care or usual care will be evaluated for inclusion. The primary outcomes will include time to clinical recovery and the probability for the negative conversion of COVID-19. Secondary outcomes will quantifythe proportion of patients relieved of symptoms, the all-cause mortality, morbidity, detection of viral RNA, time needed to achieve a negative viral load, ordinal scale changes, ventilatorand oxygen requirements,length of hospital stayand the incidence of adverse and serious adverse events.RevMan V.5.3 computer software packages will be utilised to conduct an accurate statistical analysis of the study. Thebinary random-effects model will be used at a 95 % confidence interval to estimate the weighted effect size ofdichotomous data and continuous data studies. The results of statistical analysis will be considered statistically significant whena p-value &amp;lt;0.05 is attained. Results: Selected studies will be used to evaluate the safety and efficacy of pharmacotherapy used during the management of the novel COVID-19. Conclusion: This study will be a qualitative and quantitative pool of comprehensive evidence regarding the safety and efficacy of pharmacotherapy on COVID-19.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialThis is a protocol of systematic review and meta-analysis and registered in PROSPERO (CRD42020205433).Funding StatementThis review did not received any funding support.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This review will use the published data in the public domain and no direct human subjects are involved in study. Hence, the ethical clearance is exemoted.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe additional data will be provided on request
AU  - Sah, Sujit Kumar
AU  - Undela, Krishna
AU  - Chand, Dr Sharad
AU  - Ramesh, Madhan
AU  - R, Subramanian
AU  - Gona, Oliver Joel
AU  - George, Sophia M.
AU  - Up, Nandakumar
AU  - Aryal, Santosh
AU  - P, Niharika
AU  - Shastry, C. S.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20206045
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20206045
ST  - Safety and efficacy of pharmacotherapy used for the management of COVID 19: A systematic review and meta-analysis of randomized control trials (preprint)
T2  - medRxiv
TI  - Safety and efficacy of pharmacotherapy used for the management of COVID 19: A systematic review and meta-analysis of randomized control trials (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20206045.abstract
ID  - 7788873
ER  - 

TY  - JOUR
AD  - Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.
Student Research Committee, Iran University of Medical Sciences, Tehran, Iran.
Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Clinical Laboratory, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
AN  - 33012270
AU  - Safaei, S.
AU  - Karimi-Googheri, M.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1089/vim.2020.0074
DP  - NLM
ET  - 2020/10/06
J2  - Viral immunology
LA  - eng
N1  - 1557-8976
Safaei, Sadegh
Karimi-Googheri, Masoud
Journal Article
United States
Viral Immunol. 2020 Oct 1. doi: 10.1089/vim.2020.0074.
PY  - 2020
SN  - 0882-8245
ST  - Letter to the Editor: Toll-Like Receptor Antagonists as a Potential Therapeutic Strategy Against Cytokine Storm in COVID-19-Infected Patients
T2  - Viral immunology
TI  - Letter to the Editor: Toll-Like Receptor Antagonists as a Potential Therapeutic Strategy Against Cytokine Storm in COVID-19-Infected Patients
ID  - 7785608
ER  - 

TY  - JOUR
AB  - Cytokine storm in COVID-19 infection is an excessive immune response to external stimuli where the pathogenesis is complex. The disease progresses rapidly and the mortality is high. Certain evidence shows that the severe deterioration of some patients has been closely related to the strong upregulation of cytokine production in SARS-Co-V2 induced pneumonia with an associated cytokine storm syndrome. Identification of existing approaved therapy with proven safety profile to treat hyperinflammation is critical unmet need in order to reduce COVID-19 associated mortality. To date, no specific therapeutic drugs are available to treat COVID-19 infection. Preliminary studies have shown that immune-modulatory or immune suppressive treatments might be considered as treatment choices for COVID-19, particularly in severe disease. This article review the pathogenesis and treatment strategies of COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
AD  - Division of Respirology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital. Jakarta, Indonesia. Rumende_martin@gmail.com.
AN  - 33020343
AU  - Rumende, C. M.
AU  - Susanto, E. C.
AU  - Sitorus, T. P.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
cytokine storm
hyperinflammation
LA  - eng
N1  - Rumende, Cleopas Martin
Susanto, Erwin C
Sitorus, Truely P
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):306-313.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 306-313
ST  - The Management of Cytokine Storm in COVID-19
T2  - Acta medica Indonesiana
TI  - The Management of Cytokine Storm in COVID-19
VL  - 52
ID  - 7785027
ER  - 

TY  - JOUR
AD  - Department of Cardiology, ASL3, Ospedale Villa Scassi, Genoa, Italy.
Department of Cardiology, ASL3, Ospedale PA Micone, Genoa, Italy.
AN  - 33016817
AU  - Rubartelli, P.
AU  - Toselli, A.
AU  - Camerini, A.
AU  - Lupi, G.
AU  - Romeo, M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/00015385.2020.1826702
DP  - NLM
ET  - 2020/10/06
J2  - Acta cardiologica
KW  - Covid-19
Left ventricular thrombi
Myocarditis
LA  - eng
N1  - 1784-973x
Rubartelli, Paolo
Orcid: 0000-0002-8817-6232
Toselli, Aldo
Camerini, Alberto
Lupi, Gabriele
Romeo, Maurizio
Journal Article
England
Acta Cardiol. 2020 Oct 5:1-3. doi: 10.1080/00015385.2020.1826702.
PY  - 2020
SN  - 0001-5385
SP  - 1-3
ST  - A patient with COVID-19 presenting multiple thrombi in the left ventricle
T2  - Acta cardiologica
TI  - A patient with COVID-19 presenting multiple thrombi in the left ventricle
ID  - 7785177
ER  - 

TY  - JOUR
AB  - BACKGROUND: Coronavirus Disease 2019 is an emerging respiratory disease that is now a pandemic. Indonesia is experiencing a rapid surge of cases but the local data are scarce. METHODS: this is an analysis using data from the ongoing recapitulation of Epidemiological Surveillance (ES) by the Provincial Health Office of Jakarta from March 2nd to April 27th 2020. We evaluated demographic and clinical characteristics of all confirmed cases in association with death. RESULTS: of the 4,052 patients, 381 (9.4%) patients were deceased. Multivariable analysis showed that death was associated with older age (odds ratio [OR] 1.03; 95% confidence interval [CI] 1.02, 1.05, per year increase; p0.001), dyspnea (OR 4.83; 95% CI 3.20, 7.29; p0.001), pneumonia (OR 2.46; 95%CI 1.56, 3.88; p0.001), and pre-existing hypertension (OR 1.86; 95% CI 1.24, 2.78; p=0.003). Death was highest in the week of April 6th 2020 and declined in the subsequent weeks, after a large-scale social restriction commenced. CONCLUSION: older age, dyspnea, pneumonia, and pre-existing hypertension were associated with death. Mortality was high, but may be reduced by lockdown.
AD  - National Medical Team COVID-19, the Indonesian Society of Respirology Department of Parasitology, Faculty of Medicine Universitas Indonesia. academicfkui@gmail.com.
AN  - 33020335
AU  - Rozaliyani, A.
AU  - Savitri, A. I.
AU  - Setianingrum, F.
AU  - Shelly, T. N.
AU  - Ratnasari, V.
AU  - Kuswindarti, R.
AU  - Salama, N.
AU  - Oktavia, D.
AU  - Widyastuti, W.
AU  - Handayani, D.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
Indonesia
Jakarta
death
patient characteristics
LA  - eng
N1  - Rozaliyani, Anna
Savitri, Ary Indriana
Setianingrum, Findra
Shelly, Titania Nur
Ratnasari, Vini
Kuswindarti, Romala
Salama, Ngabila
Oktavia, Dwi
Widyastuti, Widyastuti
Handayani, Diah
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):246-254.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 246-254
ST  - Factors Associated with Death in COVID-19 Patients in Jakarta, Indonesia: An Epidemiological Study
T2  - Acta medica Indonesiana
TI  - Factors Associated with Death in COVID-19 Patients in Jakarta, Indonesia: An Epidemiological Study
VL  - 52
ID  - 7785033
ER  - 

TY  - JOUR
AB  - SARS-CoV2, first described in December 2019, was declared a pandemic by the World Health Organization in March 2020. Various surgical and medical societies promptly published guidelines, based on expert opinion, on managing patients with COVID-19, with a consensus to postpone elective surgeries and procedures. We describe the case of an orthotopic liver transplantation (OLT) in a young female who presented with acute liver failure secondary to acetaminophen toxicity to manage abdominal pain and in the setting of a positive SARS-CoV2 test. Despite a positive test, she had no respiratory symptoms at time of presentation. The positive test was thought to be residual viral load. The patient had a very favorable outcome, likely related to multiple factors including her young age, lack of respiratory COVID-19 manifestations and plasma exchange peri-operatively. We recommend a full work-up for OLT in COVID-19 patients with uncomplicated disease according to standard of care, with careful interpretation of COVID-19 testing in patients presenting with conditions requiring urgent or emergent surgery as well as repeat testing even a few days after initial testing, as this could alter management.
AD  - Department of Gastroenterology and Hepatology, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Transplantation Center, Department of General Surgery, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA.
Department of General Anesthesiology, Anesthesiology Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Department of Infectious Disease, Cleveland Clinic, Cleveland, OH, USA.
Department of Critical Care, Cleveland Clinic, Cleveland, OH, USA.
AN  - 33017864
AU  - Rouphael, C.
AU  - D'Amico, G.
AU  - Ricci, K.
AU  - Cywinski, J.
AU  - Miranda, C.
AU  - Koval, C.
AU  - Duggal, A.
AU  - Quintini, C.
AU  - Menon, K. N.
AU  - Miller, C.
AU  - Modaresi Esfeh, J.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/ajt.16330
DP  - NLM
ET  - 2020/10/06
J2  - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
LA  - eng
N1  - 1600-6143
Rouphael, Carol
Orcid: 0000-0003-3492-2073
D'Amico, Giuseppe
Ricci, Kristin
Cywinski, Jacek
Miranda, Cyndee
Koval, Christine
Duggal, Abhijit
Quintini, Cristiano
Menon, Kv Narayanan
Miller, Charles
Modaresi Esfeh, Jamak
Case Reports
United States
Am J Transplant. 2020 Oct 5. doi: 10.1111/ajt.16330.
PY  - 2020
SN  - 1600-6135
ST  - Successful Orthotopic Liver Transplantation in a Patient with a Positive SARS-CoV2 Test and Acute Liver Failure Secondary to Acetaminophen Overdose
T2  - American journal of transplantation : official journal of American Society of Transplantation and American Society of Transplant Surgeons
TI  - Successful Orthotopic Liver Transplantation in a Patient with a Positive SARS-CoV2 Test and Acute Liver Failure Secondary to Acetaminophen Overdose
ID  - 7785114
ER  - 

TY  - JOUR
AU  - Rouleau, Linda
AU  - Hällgren, Markus
AU  - de Rond, Mark
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Covid 19 and Our Understanding of Risk, Emergencies, and Crises
T2  - Journal of Management Studies
TI  - Covid 19 and Our Understanding of Risk, Emergencies, and Crises
UR  - https://doi.org/10.1111/joms.12649
ID  - 7788295
ER  - 

TY  - JOUR
AD  - Cardiology Unit, Policlinico Di Modena Hospital, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy. rosario.rossi@unimore.it.
Cardiology Unit, Policlinico Di Modena Hospital, University of Modena and Reggio Emilia, Via del Pozzo 71, 41124, Modena, Italy.
AN  - 33011928
AU  - Rossi, R.
AU  - Talarico, M.
AU  - Coppi, F.
AU  - Boriani, G.
C1  - 10/6/2020
C2  - PMC7532733
DA  - Oct 3
DB  - PubMed
DO  - 10.1007/s11739-020-02504-y
DP  - NLM
ET  - 2020/10/05
J2  - Internal and emergency medicine
LA  - eng
N1  - 1970-9366
Rossi, Rosario
Orcid: 0000-0001-9065-1808
Talarico, Marisa
Coppi, Francesca
Boriani, Giuseppe
Letter
Intern Emerg Med. 2020 Oct 3:1-4. doi: 10.1007/s11739-020-02504-y.
PY  - 2020
SN  - 1828-0447 (Print)
1828-0447
SP  - 1-4
ST  - Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action
T2  - Internal and emergency medicine
TI  - Protective role of statins in COVID 19 patients: importance of pharmacokinetic characteristics rather than intensity of action
ID  - 7785644
ER  - 

TY  - JOUR
AB  - Introduction: Various drugs are being used against the symptoms caused by COVID-19, without being approved for these purposes. Many of these drugs have small safety margin and very risky adverse effects on health, a reason why they require prescription and, above all, medical monitoring and follow-up. Unfortunately, there are many cases of self-medication in Peru and Bolivia that require prompt management. Objective(s): To carry out a systematic review of the scientific literature that presents evidence about the effectiveness and adverse reactions of the drugs currently used against COVID-19 in Peru and Bolivia. Method(s): Qualitative research based on the systematic review of the scientific literature available in PubMed, as well as in the national regulations of Peru and Bolivia related to the etiology, epidemiology, symptoms, as well as treatments approved and discontinued by both countries since the exacerbation of the COVID-19 crisis and the completion of clinical studies to date. Conclusion(s): The drugs used in Peru and Bolivia for treating COVID-19 have side effects and possible risks to the health of people who unfortunately self-medicate. Greater control of these drugs is required to avoid their free acquisition, and to improve the national and regional strategy to evaluate the possible symptomatic treatments of COVID-19, taking into consideration the high probability of survival of the disease and the risk posed by using these drugs, which, in the future, could cause serious adverse effects on public health in the two countries. Copyright © 2020, Editorial Ciencias Medicas. All rights reserved.
AD  - (Roman, Moscoso, Chung, Terceros) Universidad Cristiana de Bolivia, Comunidad Cientifica de Estudiantes de Medicina, Santa Cruz, Bolivia (Alvarez-Risco) Universidad de Lima, Facultad de Ciencias Empresariales y Economicas. Carrera de Negocios Internacionales, Lima, Peru (Yanez) Universidad Peruana de Ciencias Aplicadas, Facultad de Educacion, Carrera de Educacion y Gestion del Aprendizaje, Lima, Peru (Yanez) Teoma Global, Gerencia Corporativa de Asuntos Cientificos y Regulatorios, Lima, Peru
J.A. Yanez, Universidad Peruana de Ciencias Aplicadas, Facultad de Educacion, Carrera de Educacion y Gestion del Aprendizaje, Lima, Peru. E-mail: jaimeayanez@gmail.com J.A. Yanez, Teoma Global, Gerencia Corporativa de Asuntos Cientificos y Regulatorios, Lima, Peru. E-mail: jaimeayanez@gmail.com
AN  - 2005143291
AU  - Roman, B. R.
AU  - Moscoso, S.
AU  - Chung, S. A.
AU  - Terceros, B. L.
AU  - Alvarez-Risco, A.
AU  - Yanez, J. A.
C1  - 10/6/2020
DA  - April-June
DB  - Embase
DP  - Ovid Technologies
IS  - 2
KW  - Bolivia
covid-19
Drugs
Peru
Self-medication
Strategy
Treatment
adverse drug reaction
article
coronavirus disease 2019
disease exacerbation
human
Medline
palliative therapy
probability
public health
qualitative research
scientific literature
self medication
side effect
systematic review
LA  - Spanish
PY  - 2020
SN  - 0034-7515
1561-2988
SP  - 1-20
ST  - Treatment of COVID-19 in peru and bolivia, and self-medication risks. [Spanish]
T2  - Revista Cubana de Farmacia
TI  - Treatment of COVID-19 in peru and bolivia, and self-medication risks. [Spanish]
TT  - Tratamiento de la COVID-19 en peru y bolivia y los riesgos de la automedicacion.
UR  - http://www.revfarmacia.sld.cu/index.php/far/article/download/435/310
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005143291
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=&issn=0034-7515&isbn=&volume=53&issue=2&spage=1&pages=1-20&date=2020&title=Revista+Cubana+de+Farmacia&atitle=Tratamiento+de+la+COVID-19+en+peru+y+bolivia+y+los+riesgos+de+la+automedicacion&aulast=Roman&pid=%3Cauthor%3ERoman+B.R.%2CMoscoso+S.%2CChung+S.A.%2CTerceros+B.L.%2CAlvarez-Risco+A.%2CYanez+J.A.%3C%2Fauthor%3E&%3CAN%3E2005143291%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 53
ID  - 7783007
ER  - 

TY  - JOUR
AB  - In the wake of the sudden spread of COVID-19, a large amount of the Italian population practiced incongruous behaviors with the protective health measures. The present study aimed at examining psychological and psychosocial variables that could predict behavioral compliance. An online survey was administered from 18-22 March 2020 to 2766 participants. Paired sample t-tests were run to compare efficacy perception with behavioral compliance. Mediation and moderated mediation models were constructed to explore the association between perceived efficacy and compliance, mediated by self-efficacy and moderated by risk perception and civic attitudes. Machine learning algorithms were trained to predict which individuals would be more likely to comply with protective measures. Results indicated significantly lower scores in behavioral compliance than efficacy perception. Risk perception and civic attitudes as moderators rendered the mediating effect of self-efficacy insignificant. Perceived efficacy on the adoption of recommended behaviors varied in accordance with risk perception and civic engagement. The 14 collected variables, entered as predictors in machine learning models, produced an ROC area in the range of 0.82-0.91 classifying individuals as high versus low compliance. Overall, these findings could be helpful in guiding age-tailored information/advertising campaigns in countries affected by COVID-19 and directing further research on behavioral compliance.
AD  - Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Department of General Psychology, University of Padova, 35131 Padova, Italy.
Department of Dynamic and Clinical Psychology, Sapienza University of Rome, 00185 Rome, Italy.
Department of Medical Surgical Science and Translational Medicine, Sapienza University of Rome, 00189 Rome, Italy.
Department of Neuroscience, Imaging and Clinical Sciences, University "G.d'Annunzio", 66100 Chieti-Pescara, Italy.
AN  - 33020395
AU  - Roma, P.
AU  - Monaro, M.
AU  - Muzi, L.
AU  - Colasanti, M.
AU  - Ricci, E.
AU  - Biondi, S.
AU  - Napoli, C.
AU  - Ferracuti, S.
AU  - Mazza, C.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.3390/ijerph17197252
DP  - NLM
ET  - 2020/10/07
IS  - 19
J2  - International journal of environmental research and public health
KW  - Covid-19
civic engagement
compliance
efficacy
personality
risk perception
LA  - eng
N1  - 1660-4601
Roma, Paolo
Orcid: 0000-0002-1031-0948
Monaro, Merylin
Muzi, Laura
Colasanti, Marco
Ricci, Eleonora
Biondi, Silvia
Napoli, Christian
Orcid: 0000-0002-5775-2276
Ferracuti, Stefano
Orcid: 0000-0003-1150-1460
Mazza, Cristina
Orcid: 0000-0002-2554-8094
Journal Article
Switzerland
Int J Environ Res Public Health. 2020 Oct 4;17(19):E7252. doi: 10.3390/ijerph17197252.
PY  - 2020
SN  - 1660-4601
ST  - How to Improve Compliance with Protective Health Measures during the COVID-19 Outbreak: Testing a Moderated Mediation Model and Machine Learning Algorithms
T2  - International journal of environmental research and public health
TI  - How to Improve Compliance with Protective Health Measures during the COVID-19 Outbreak: Testing a Moderated Mediation Model and Machine Learning Algorithms
VL  - 17
ID  - 7785025
ER  - 

TY  - JOUR
AB  - Drastic changes in electricity demand have been observed since March 2020 in Europe, after several countries implemented lockdown-like measures to contain the spread of COVID-19 We investigate the sensitivity of the electricity-water nexus in the European electric grid to large-scale behavior changes during the COVID-19 pandemic lockdown-like measures We quantify changes in the blue virtual water trade between five European countries heavily affected by COVID-19 during the same period As a result, the consumptive water footprint of thermal power plant operations in Europe decreased by 1 77 x 10(6) m(3)/day during the COVID-19 lockdowns, compared to the average of the past four years Reduced electricity demand accounts for 16% (0 29 x 10(6) m(3)/day) of the decrease, while the remainder is attributable to changes in the electricity generation mix toward less water-intensive technologies before 2020 and during lockdowns Virtual water transfers associated with electricity were also affected: Italy, a hotspot of COVID-19, reduced its water footprint by 8 4% and its virtual water imports by 70,700 m(3)/day Germany and France slightly reduced their domestic water footprint of electricity but increased their virtual water imports These findings improve our understanding of the impacts of large-scale behavior and technological changes to the European electricity-water nexus
AU  - Roidt, Mario
AU  - Chini, Christopher M.
AU  - Stillwell, Ashlynn S.
AU  - Cominola, Andrea
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Unlocking the Impacts of COVID-19 Lockdowns: Changes in Thermal Electricity Generation Water Footprint and Virtual Water Trade in Europe
T2  - Environmental Science & Technology Letters
TI  - Unlocking the Impacts of COVID-19 Lockdowns: Changes in Thermal Electricity Generation Water Footprint and Virtual Water Trade in Europe
UR  - https://doi.org/10.1021/acs.estlett.0c00381
ID  - 7788207
ER  - 

TY  - JOUR
AB  - OBJECTIVES: The Janus kinase (JAK) inhibitor baricitinib may block viral entry into pneumocytes and prevent cytokine storm in patients with SARS-CoV-2 pneumonia. We aimed to assess whether baricitinib improved pulmonary function in patients treated with high-dose corticosteroids for moderate to severe SARS-CoV-2 pneumonia. METHODS: This observational study enrolled patients with moderate to severe SARS-CoV-2 pneumonia [arterial oxygen partial pressure (PaO2)/fraction of inspired oxygen (FiO2) 200 mmHg] who received lopinavir/ritonavir and HCQ plus either corticosteroids (CS group, n�?�?0) or corticosteroids and baricitinib (BCT-CS group, n�?�?2). The primary end point was the change in oxygen saturation as measured by pulse oximetry (SpO2)/FiO2 from hospitalization to discharge. Secondary end points included the proportion of patients requiring supplemental oxygen at discharge and 1 month later. Statistics were adjusted by the inverse propensity score weighting (IPSW). RESULTS: A greater improvement in SpO2/FiO2 from hospitalization to discharge was observed in the BCT-CS vs CS group (mean differences adjusted for IPSW, 49; 95% CI: 22, 77; P �?.001). A higher proportion of patients required supplemental oxygen both at discharge (62.0% vs 25.8%; reduction of the risk by 82%, OR adjusted for IPSW, 0.18; 95% CI: 0.08, 0.43; P  0.001) and 1 month later (28.0% vs 12.9%, reduction of the risk by 69%, OR adjusted for IPSW, 0.31; 95% CI: 0.11, 0.86; P�?�?.024) in the CS vs BCT-CS group. CONCLUSIONS: . In patients with moderate to severe SARS-CoV-2 pneumonia a combination of baricitinib with corticosteroids was associated with greater improvement in pulmonary function when compared with corticosteroids alone. TRIAL REGISTRATION: European Network of Centres for Pharmacoepidemiology and Pharmacovigilance, ENCEPP (EUPAS34966, http://www.encepp.eu/encepp/viewResource.htm? id = 34967).
AD  - Internal Medicine.
Rheumatology, General University Hospital of Albacete, Albacete.
Internal Medicine, Principe de Asturias University Hospital, Alcala de Henares.
Pharmacy.
Anaesthesiology.
Infectious Diseases, General University Hospital of Albacete, Albacete, Spain.
AN  - 33020836
AU  - Rodriguez-Garcia, J. L.
AU  - Sanchez-Nievas, G.
AU  - Arevalo-Serrano, J.
AU  - Garcia-Gomez, C.
AU  - Jimenez-Vizuete, J. M.
AU  - Martinez-Alfaro, E.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/rheumatology/keaa587
DP  - NLM
ET  - 2020/10/07
J2  - Rheumatology (Oxford, England)
KW  - Covid-19
SARS-CoV-2
baricitinib
corticosteroids
LA  - eng
N1  - 1462-0332
Rodriguez-Garcia, Jose Luis
Sanchez-Nievas, Gines
Arevalo-Serrano, Juan
Garcia-Gomez, Cristina
Jimenez-Vizuete, Jose Maria
Martinez-Alfaro, Elisa
Journal Article
England
Rheumatology (Oxford). 2020 Oct 6:keaa587. doi: 10.1093/rheumatology/keaa587.
PY  - 2020
SN  - 1462-0324
ST  - Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: an observational cohort study
T2  - Rheumatology (Oxford, England)
TI  - Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: an observational cohort study
ID  - 7784971
ER  - 

TY  - JOUR
AB  - In December 2019, cases of acute respiratory illness of unknown origin were reported in Wuhan, China. The disease is caused by "severe acute respiratory syndrome coronavirus 2". After identifying severe lung damage, injury to other organs, such as the kidney, has been identified. Peritoneal dialysis is a renal replacement therapy (RRT) and is at least as effective as other extracorporeal therapy options, with significant cost-effective advantages. However, this strategy is rarely used for the management of acute kidney injury in severe lung disease. In this review, we explore PD as an RRT strategy that may be a key instrument in countries and hospitals with limited access to all RRTs.
AD  - Nephrology Department, Centro Médico Issemym Toluca, Toluca de Lerdo, Mexico, jm.rodriguez.chagolla@gmail.com.
Nephrology Department, Instituto Nacional de Cardiolog�Ta Ignacio Ch֙vez, Ciudad de México, Mexico.
Nephrology Department, Centro Médico Issemym Toluca, Toluca de Lerdo, Mexico.
AN  - 33017826
AU  - Rodr�Tguez-Chagolla, J. M.
AU  - V֙squez Jiménez, E.
AU  - Herrera Arellano, L.
AU  - Villa Torres, A.
AU  - Acosta Garc�Ta, N.
AU  - Aleman Quimbiulco, D.
AU  - Armeaga Aguilar, S.
AU  - Madero, M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1159/000511390
DP  - NLM
ET  - 2020/10/06
J2  - Blood purification
KW  - Acute kidney injury
COVID-19 disease
Peritoneal dialysis
LA  - eng
N1  - 1421-9735
Rodr�Tguez-Chagolla, José M
V֙squez Jiménez, Enzo
Herrera Arellano, Leticia
Villa Torres, Alberto
Acosta Garc�Ta, Nayeli
Aleman Quimbiulco, Dolores
Armeaga Aguilar, Sergio
Madero, Magdalena
Journal Article
Review
Switzerland
Blood Purif. 2020 Oct 5:1-7. doi: 10.1159/000511390.
PY  - 2020
SN  - 0253-5068
SP  - 1-7
ST  - Peritoneal Dialysis Is an Option for Acute Kidney Injury Management in Patients with COVID-19
T2  - Blood purification
TI  - Peritoneal Dialysis Is an Option for Acute Kidney Injury Management in Patients with COVID-19
ID  - 7785118
ER  - 

TY  - JOUR
AD  - Respiratory Medicine, Cochin Hospital, APHP. Centre University of Paris, Inserm UMR1016, Paris, France.
Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Respiratory Paediatrics, Imperial College and Royal Brompton Hospital, London, UK.
Dept of Respiratory Science, NIHR Biomedical Research Centre, Institute for Lung Health University of Leicester, Leicester, UK.
Dept of Medicine and Pathology, McMaster University, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, ON, Canada.
Dept of Molecular Medicine, McMaster University, Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, ON, Canada.
Respiratory Physiology, Cochin Hospital, APHP, Centre University of Paris, Paris, France.
Dept of Respiratory and Intensive Care Medicine, Université Paris-Saclay, Faculty of Medicine, Inserm UMR_S 999, Assistance Publique - Hôpitaux de Paris (AP-HP), Hôpital Bic�^tre, Le Kremlin-Bic�^tre, France.
Sleep and Ventilation Unit, Royal Brompton & Harefield NHS Foundation Trust, London, UK.
Lady Davis Carmel Medical Center, Pulmonary Division, Faculty of Medicine, Technion Institute of Technology, Haifa, Israel.
AN  - 33020070
AU  - Roche, N.
AU  - Tonia, T.
AU  - Bush, A.
AU  - Brightling, C.
AU  - Kolb, M.
AU  - Dinh-Xuan, A. T.
AU  - Humbert, M.
AU  - Simonds, A.
AU  - Adir, Y.
C1  - 10/6/2020
DA  - Sep 30
DB  - PubMed
DO  - 10.1183/16000617.0310-2020
DP  - NLM
ET  - 2020/10/07
IS  - 157
J2  - European respiratory review : an official journal of the European Respiratory Society
LA  - eng
N1  - 1600-0617
Roche, Nicolas
Tonia, Thomy
Bush, Andrew
Brightling, Chris
Kolb, Martin
Orcid: 0000-0003-3837-1467
Dinh-Xuan, Anh Tuan
Orcid: 0000-0001-8651-5176
Humbert, Marc
Orcid: 0000-0003-0703-2892
Simonds, Anita
Adir, Yochai
Editorial
England
Eur Respir Rev. 2020 Oct 5;29(157):200310. doi: 10.1183/16000617.0310-2020. Print 2020 Sep 30.
PY  - 2020
SN  - 0905-9180
ST  - Guidance production before evidence generation for critical issues: the example of COVID-19
T2  - European respiratory review : an official journal of European Respiratory Society
TI  - Guidance production before evidence generation for critical issues: the example of COVID-19
VL  - 29
ID  - 7785056
ER  - 

TY  - JOUR
AB  - The vocabulary used in news on a disease such as COVID-19 changes according the period [4]. This aspect is discussed on the basis of MEDISYS-sourced media datasets via two studies. The first focuses on terminology extraction and the second on period prediction according to the textual content using machine learning approaches.
AD  - CIRAD, UMR TETIS, F-34398 Montpellier, France.
TETIS, Univ Montpellier, AgroParisTech, CIRAD, CNRS, INRAE, Montpellier, France.
AN  - 33015251
AU  - Roche, M.
C1  - 10/6/2020
C2  - PMC7525263
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.dib.2020.106356
DP  - NLM
ET  - 2020/10/06
J2  - Data in brief
KW  - Covid-19
Classification
Corpus
Nlp
Terminology Extraction
Text-Mining
LA  - eng
N1  - 2352-3409
Roche, Mathieu
Journal Article
Data Brief. 2020 Sep 30:106356. doi: 10.1016/j.dib.2020.106356.
PY  - 2020
SN  - 2352-3409
SP  - 106356
ST  - COVID-19 and Media Datasets: Period- and location-specific textual data mining
T2  - Data in brief
TI  - COVID-19 and Media Datasets: Period- and location-specific textual data mining
ID  - 7785324
ER  - 

TY  - JOUR
AB  - COVID-19 is an emerging outbreak similar to previous pandemics caused by Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). Till date, SARS-CoV-2 infection is still spreading, representing a major threat to public health, where several control measures are being practiced in order to culminate its spread. The research and development of new drugs require a lot of funding in addition to being a slow and costly process. As a result, new techniques have been proposed to streamline this process. The repositioning or repurposing of drugs represents an attractive strategy, presenting a promising way to introduce new drugs. Currently, numerous reused drugs are already available in the market and are in practice. In this review, it was observed that the antiviral drugs Entricitabine and Tenofovir display potential therapeutic efficacy in preclinical studies. Therefore, in silico analyses were considered a potential tool for predicting the effectiveness of drugs, mainly as an effective approach to encourage a complementary in vitro and in vivo antiviral evaluation.
AD  - Programa de P�Qs-Graduação em Ci�^ncias Farmac�^uticas, Universidade Federal do Cear֙ (UFC), Fortaleza-CE. Brazil.
Universidade Estadual do Cear֙ (UECE), Fortaleza-CE-. Brazil.
Rede Nordeste de Biotecnologia (Renorbio), Universidade Estadual do Cear֙ (UECE), Fortaleza-CE-. Brazil.
International University for the Integration of AfroBrazilian Lusophony (UNILAB), Redenção-CE. Brazil.
AN  - 33019921
AU  - Rocha, Y. M.
AU  - de Moura, G. A.
AU  - de Oliveira, J. R.
AU  - de Figueiredo Nicolete, L. D.
AU  - Nicolete, R.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.2174/0929867327666201005113204
DP  - NLM
ET  - 2020/10/07
J2  - Current medicinal chemistry
KW  - Covid-19
SARS-CoV-2
antivirals
drugs
repurposing
treatment
LA  - eng
N1  - 1875-533x
Rocha, Yasmim Mendes
de Moura, Gabriel Ac֙cio
de Oliveira, Juliana Ramos
de Figueiredo Nicolete, Larissa Deadame
Nicolete, Roberto
Journal Article
United Arab Emirates
Curr Med Chem. 2020 Oct 5. doi: 10.2174/0929867327666201005113204.
PY  - 2020
SN  - 0929-8673
ST  - Potential repurposing of drugs with anti-SARS-CoV-2 activity in preclinical trials: a systematic review
T2  - Current medicinal chemistry
TI  - Potential repurposing of drugs with anti-SARS-CoV-2 activity in preclinical trials: a systematic review
ID  - 7785071
ER  - 

TY  - JOUR
AB  - Objective: The evidence pertaining to the effects of asthma on Coronavirus disease 2019 outcomes has been unclear. To improve our understanding of the clinically important association of asthma and Coronavirus disease 2019. Methods: A matched cohort study was performed using data from the Mass General Brigham Health Care System (Boston, MA). Adult (age �?18 years) patients with confirmed Coronavirus disease 2019 and without chronic obstructive pulmonary disease, cystic fibrosis, or interstitial lung disease between March 4, 2020 and July 2, 2020 were analyzed. Up to 5 non-asthma comparators were matched to each asthma patient based on age (within 5 years), sex, and date of positive test (within 7 days). The primary outcomes were hospitalization, mechanical ventilation, and death, using multivariable Cox-proportional hazards models accounting for competing risk of death, when appropriate. Patients were followed for these outcomes from diagnosis of Coronavirus disease 2019 until July 2, 2020. Results: Among 562 asthma patients, 199 (21%) were hospitalized, 15 (3%) received mechanical ventilation, and 7 (1%) died. Among the 2686 matched comparators, 487 (18%) were hospitalized, 107 (4%) received mechanical ventilation, and 69 (3%) died. The adjusted Hazard Ratios among asthma patients were 0.99 (95% Confidence Internal 0.80, 1.22) for hospitalization, 0.69 (95% Confidence Internal 0.36, 1.29) for mechanical ventilation, and 0.30 (95% Confidence Internal 0.11, 0.80) for death. Conclusions: In this matched cohort study from a large Boston-based healthcare system, asthma was associated with comparable risk of hospitalization and mechanical ventilation but a lower risk of mortality.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo specific funding was received for this project. Dr. Camargo is supported, in part, by grant R01AI127507 from the National Institutes of Health. Dr. Blumenthal is supported by National Institutes of Health K01AI125631, the American Academy of Allergy Asthma and Immunology Foundation (AAAAI), and the Massachusetts General Hospital Claflin Distinguished Scholars Award. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health, AAAAI Foundation, nor the MGH.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study was reviewed by the Partners Human Research Committee and determined to be exempt/non-human subjects research (Protocol 2020P000833).All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data are from Mass General Brigham and are not publicly available.
AU  - Robinson, Lacey B.
AU  - Wang, Liqin
AU  - Fu, Xiaoqing
AU  - Wallace, Zachary S.
AU  - Long, Aidan A.
AU  - Zhang, Yuqing
AU  - Camargo, Carlso A.
AU  - Blumenthal, Kimberly G.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205724
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205724
ST  - COVID-19 severity in asthma patients: A multi-center matched cohort study (preprint)
T2  - medRxiv
TI  - COVID-19 severity in asthma patients: A multi-center matched cohort study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205724.abstract
ID  - 7788878
ER  - 

TY  - JOUR
AB  - Background: In December 2019 a novel human coronavirus (COVID-19) was identified in Wuhan, China (Wu et al, 2020). The virus subsequently spread to most countries worldwide and the World Health Organisation characterised the outbreak a pandemic on March 11 (th) 2020 (WHO, 2020a). Older age is associated with an increased risk of mortality in patients with COVID-19 (Chen et al., 2020). In March 2020, the Irish Government introduced 'cocooning' as a measure for those over 70 years of age to minimise interactions with others by not leaving their homes (Dept. of Health, 2020). The COVID-19 pandemic presents unique threats to the health and well-being of older adults. This study aims to explore the longitudinal experiences and beliefs of older adults during the COVID-19 pandemic. Findings will be important for tailoring supports, interventions and public health information for this population. Methods: A longitudinal exploratory qualitative study will be conducted using repeated semi-structured telephone interviews with a convenient sample of older adults recruited from participants of an older adult and family carer stakeholder panel for health services research established by the Ageing Research Centre (ARC) at the University of Limerick and through known older adult contacts of ARC academic members. Interviews will be audio recorded, transcribed and analysed using a reflexive approach to thematic analysis. Participants will have the opportunity to review and discuss preliminary analysis of the interview data and to co-write / design dissemination materials. Ethics and Dissemination: Ethical approval has been granted by the Faculty of Education and Health Sciences University of Limerick, Research Ethics Committee (2020_03_51_EHS (ER)). Findings will be disseminated through open access journal publications and distribution of lay summaries, a press release and an infographic to organisations of and for older people in Ireland, broadcast and print media.
AD  - School of Allied Health, University of Limerick, Limerick, V94 T9PX, Ireland.
Ageing Research Centre, Health Research Institute, University of Limerick, Limerick, V94 T9PX, Ireland.
Department of Nursing and Midwifery, University of Limerick, Limerick, V94 T9PX, Ireland.
AN  - 33015540
AU  - Robinson, K.
AU  - O'Neill, A.
AU  - Conneely, M.
AU  - Morrissey, A.
AU  - Leahy, S.
AU  - Meskell, P.
AU  - Pettigrew, J.
AU  - Galvin, R.
C1  - 10/6/2020
C2  - PMC7509595
DB  - PubMed
DO  - 10.12688/hrbopenres.13031.1
DP  - NLM
ET  - 2020/10/06
J2  - HRB open research
KW  - Covid-19
Older adults
Public and Patient Involvement
Qualitative Research
LA  - eng
N1  - 2515-4826
Robinson, Katie
Orcid: 0000-0003-1008-9857
O'Neill, Aoife
Orcid: 0000-0002-8670-6738
Conneely, Mairead
Orcid: 0000-0002-9233-2007
Morrissey, AnnMarie
Leahy, Siobhan
Meskell, Pauline
Orcid: 0000-0002-0218-5390
Pettigrew, Judi
Galvin, Rose
Orcid: 0000-0002-8171-224x
Journal Article
HRB Open Res. 2020 Apr 20;3:16. doi: 10.12688/hrbopenres.13031.1. eCollection 2020.
PY  - 2020
SN  - 2515-4826
SP  - 16
ST  - Exploring the beliefs and experiences of older Irish adults and family carers during the novel coronavirus (COVID-19) pandemic: A qualitative study protocol
T2  - HRB open research
TI  - Exploring the beliefs and experiences of older Irish adults and family carers during the novel coronavirus (COVID-19) pandemic: A qualitative study protocol
VL  - 3
ID  - 7785297
ER  - 

TY  - JOUR
AB  - Introduction: The world-wide lockdown caused by Coronavirus Disease 2019 (COVID-19) has upended the trajectories of lives everywhere. The medical profession has been on the front lines of this rapidly developing situation, which in turn has called for unprecedented changes in the medical school curriculum. These changes have severe implications for medical students interested in applying to competitive surgical specialties like orthopedics. Method(s): As medical students in 3 different class years pursuing orthopedic surgery, we provide our perspectives on the impact that COVID-19 has had on medical student orthopedic education. Result(s): With the removal of away rotations and a shift to virtual interviews, rising fourth year medical students are arguably the most impacted as they prepare for the orthopedic residency application process. Third year students, who are in the exploratory phase of choosing a specialty, also face uncertainties in the shift to a "new" clerkship experience that may (1) be of shorter duration, (2) implement shifts to limit overcrowding of clinical space, and (3) increase the use of telehealth over direct patient contact. Discussion(s): The COVID-19 pandemic has altered the course of medical students' orthopedic education in unprecedented ways. We believe the following suggestions may be helpful for students seeking alternative, supplemental ways of learning: (1) read up on major orthopedic journals, (2) reach out to orthopedic surgeons in areas of interest, (3) reach out to program directors/medical clerkship directors/program coordinators for opportunities to attend their educational curriculum virtually, (4) attend online lectures and hospital grand rounds, and (5) practice suturing technique with a practice kit. Conclusion(s): While the medical education landscape remains uncertain amid the evolving conditions of COVID-19, as medical students we strive to learn from this pandemic and respond to future unforeseen challenges with resilience, dedication, and compassion: all qualities we admire in orthopedic surgeons. Copyright © The Author(s) 2020.
AD  - (Richardson) University of Rochester School of Medicine and Dentistry, Rochester, NY, United States (Islam, Magruder) Weill Cornell Medical College, New York, NY, United States
M.A. Richardson, University of Rochester School of Medicine and Dentistry, Rochester, NY, United States. E-mail: michelle_richardson@urmc.rochester.edu
AN  - 2006822752
AU  - Richardson, M. A.
AU  - Islam, W.
AU  - Magruder, M.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1177/2151459320951721
DP  - Ovid Technologies
IS  - no pagination
KW  - away rotation
clerkship
covid-19
medical education
residency application
adult
article
coronavirus disease 2019
crowding (area)
curriculum
human
interview
learning
medical student
orthopedic surgeon
orthopedic surgery
pandemic
rotation
suture technique
telehealth
uncertainty
imidacloprid
LA  - English
N1  - Using Smart Source Parsing
( Date of Publication: 2020
PY  - 2020
SN  - 2151-4585
2151-4593
ST  - The Evolving Impact of COVID-19 on Medical Student Orthopedic Education: Perspectives From Medical Students in Different Phases of the Curriculum
T2  - Geriatric Orthopaedic Surgery and Rehabilitation
TI  - The Evolving Impact of COVID-19 on Medical Student Orthopedic Education: Perspectives From Medical Students in Different Phases of the Curriculum
UR  - http://gos.sagepub.com/
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006822752
VL  - 11
ID  - 7782962
ER  - 

TY  - JOUR
AB  - Chloroquine (CQ) and hydroxychloroquine (HCQ) are derivatives of 4-aminoquinoline compounds with over 60 years of safe clinical usage. CQ and HCQ are able to inhibit the production of cytokines such as interleukin- (IL-) 1, IL-2, IL-6, IL-17, and IL-22. Also, CQ and HCQ inhibit the production of interferon- (IFN-) �� and IFN-�� and/or tumor necrotizing factor- (TNF-) ��. Furthermore, CQ blocks the production of prostaglandins (PGs) in the intact cell by inhibiting substrate accessibility of arachidonic acid necessary for the production of PGs. Moreover, CQ affects the stability between T-helper cell (Th) 1 and Th2 cytokine secretion by augmenting IL-10 production in peripheral blood mononuclear cells (PBMCs). Additionally, CQ is capable of blocking lipopolysaccharide- (LPS-) triggered stimulation of extracellular signal-modulated extracellular signal-regulated kinases 1/2 in human PBMCs. HCQ at clinical levels effectively blocks CpG-triggered class-switched memory B-cells from differentiating into plasmablasts as well as producing IgG. Also, HCQ inhibits cytokine generation from all the B-cell subsets. IgM memory B-cells exhibits the utmost cytokine production. Nevertheless, CQ triggers the production of reactive oxygen species. A rare, but serious, side effect of CQ or HCQ in nondiabetic patients is hypoglycaemia. Thus, in critically ill patients, CQ and HCQ are most likely to deplete all the energy stores of the body leaving the patient very weak and sicker. We advocate that, during clinical usage of CQ and HCQ in critically ill patients, it is very essential to strengthen the CQ or HCQ with glucose infusion. CQ and HCQ are thus potential inhibitors of the COVID-19 cytokine storm.
AD  - Department of Medicine, Princefield University, P. O. Box MA128, Ho, Ghana West Africa, ; Department of Anesthesia and Critical Care, School of Medicine, University of Health and Allied Sciences, Ho, Ghana ; Department of Pharmacy, Ho Teaching Hospital, P.O. Box MA374, Ho, Ghana West Africa, ; Department of Surgery, School of Medicine and Health Science, University for Development Studies, Tamale, Ghana ; Department of Clinical Microbiology, School of Medicine and Health Science, University for Development Studies, Tamale, Ghana ; Department of Clinical Medicine, Habana Medical Services, Tamale, Ghana ; Department of Medicine, Princefield University, P. O. Box MA128, Ho, Ghana West Africa
AN  - 2448257908
AU  - Richard, Seidu A.
AU  - Kampo, Sylvanus
AU  - Hechavarria, Maite Esquijarosa
AU  - Sackey, Marian
AU  - Buunaaim, Alexis D. B.
AU  - Kuugbee, Eugene Dogkotenge
AU  - Anabah, Thomas Winsum
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/4582612
DP  - ProQuest Central
KW  - Medical Sciences--Allergology And Immunology
Plasma
Acids
Rheumatoid arthritis
Lymphocytes T
Hydroxychloroquine
Lupus
Reactive oxygen species
Immunomodulation
Interleukin 17
Arachidonic acid
Autophagy
Cell differentiation
Kinases
Rare species
Interleukin 10
Interleukin 6
Chloroquine
Hypoglycemia
Drug dosages
Immunological memory
Proteins
Interleukin 2
Inflammation
Prostaglandins
Malaria
Human immunodeficiency virus--HIV
CpG islands
Autoimmune diseases
Immunoglobulin M
Memory cells
Lipopolysaccharides
Immunoglobulin G
Viruses
Tumor necrosis factor-TNF
Leukocytes (mononuclear)
Interleukin 22
Lymphocytes B
Enzymes
��-Interferon
LA  - English
N1  - Copyright - Copyright © 2020 Seidu A. Richard et al. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
PY  - 2020
SN  - 23148861
ST  - Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine
T2  - Journal of Immunology Research
TI  - Elucidating the Pivotal Immunomodulatory and Anti-Inflammatory Potentials of Chloroquine and Hydroxychloroquine
UR  - https://www.proquest.com/docview/2448257908?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Elucidating+the+Pivotal+Immunomodulatory+and+Anti-Inflammatory+Potentials+of+Chloroquine+and+Hydroxychloroquine&title=Journal+of+Immunology+Research&issn=23148861&date=2020-01-01&volume=2020&issue=&spage=&au=Richard%2C+Seidu+A%3BKampo%2C+Sylvanus%3BHechavarria%2C+Maite+Esquijarosa%3BSackey%2C+Marian%3BBuunaaim%2C+Alexis+D+B%3BKuugbee%2C+Eugene+Dogkotenge%3BAnabah%2C+Thomas+Winsum&isbn=&jtitle=Journal+of+Immunology+Research&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F4582612
VL  - 2020
ID  - 7784946
ER  - 

TY  - JOUR
AD  - Division of Cardiovascular Medicine, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Division of Cardiology, Columbia University Irving Medical Center, New York, NY.
Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins School of Medicine, Baltimore, MD.
AN  - 33016784
AU  - Reza, N.
AU  - DeFilippis, E. M.
AU  - Michos, E. D.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1161/circulationaha.120.049792
DP  - NLM
ET  - 2020/10/06
J2  - Circulation
LA  - eng
N1  - 1524-4539
Reza, Nosheen
DeFilippis, Ersilia M
Michos, Erin D
Journal Article
United States
Circulation. 2020 Oct 5. doi: 10.1161/CIRCULATIONAHA.120.049792.
PY  - 2020
SN  - 0009-7322
ST  - The Cascading Effects of COVID-19 on Women in Cardiology
T2  - Circulation
TI  - The Cascading Effects of COVID-19 on Women in Cardiology
ID  - 7785180
ER  - 

TY  - JOUR
AN  - 33012275
AU  - Reviglio, V. E.
AU  - Osaba, M.
AU  - Chiaradia, P.
AU  - Arevalo, J. F.
C1  - 10/6/2020
DA  - Dec
DB  - PubMed
DO  - 10.1080/10872981.2020.1830680
DP  - NLM
ET  - 2020/10/06
IS  - 1
J2  - Medical education online
LA  - eng
N1  - 1087-2981
Reviglio, Victor Eduardo
Osaba, Matias
Chiaradia, Pablo
Arevalo, J Fernando
Editorial
United States
Med Educ Online. 2020 Dec;25(1):1830680. doi: 10.1080/10872981.2020.1830680.
PY  - 2020
SN  - 1087-2981
SP  - 1830680
ST  - Academic ophthalmology in the post-COVID-19 era
T2  - Medical education online
TI  - Academic ophthalmology in the post-COVID-19 era
VL  - 25
ID  - 7785606
ER  - 

TY  - GEN
AN  - NCT04577235
AU  - Research, Gaziosmanpasa Taksim
AU  - Hospital, Education
C1  - 10/6/2020
DA  - June 5
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - covid-19
N1  - No Results Available
Other: severity of lung involvement with COVID-19.
The evaluation of the correlation between the baseline LUS score and mortality rate of patients with severe COVID-19 pneumonia who were followed up in the intensive care unit|The evaluation of the correlation between the baseline CT score and mortality rate of patients with severe COVID-19 pneumonia who were followed up in the intensive care unit
All
Not Applicable
29
Other
Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Diagnostic
AyşeV
September 5, 2020
PB  - https://ClinicalTrials.gov/show/NCT04577235
PY  - 2020
ST  - Correlation Between Thoracic Ultrasound and Thorax Computed Tomography Scores
T2  - ClinicalTrials
TI  - Correlation Between Thoracic Ultrasound and Thorax Computed Tomography Scores
UR  - https://ClinicalTrials.gov/show/NCT04577235
ID  - 7788856
ER  - 

TY  - JOUR
AB  - In the current coronavirus SARS-CoV-2 pandemic, certain patients are becoming seriously ill. Lung pathologies are common, and some patients even go on to develop acute respiratory distress syndrome (ARDS), which requires intubation and artificial respiration of the critically ill patient. Imaging of the lung is absolutely necessary to obtain a diagnosis, assess the course of disease and for treatment. Particularly in gynecology and obstetrics (OBGYN), ultrasound scans of the lung can be a useful additional tool when caring for pregnant patients in the delivery room. As obstetricians use ultrasound imaging a lot in routine clinical practice, in the current pandemic setting, routine prenatal imaging screening could be expanded by the addition of ultrasound scans of the lung. Lung sonography can offer important additional information, particularly in obstetrics where the indications for radiation-emitting imaging are particularly restrictive. If there is a sonographic suspicion of lung involvement, then, depending on the symptoms and the morphological extent of the ultrasound findings, it may be necessary to consider admitting the patient to hospital for close fetal and maternal monitoring.
AD  - Zentrum für Frauenheilkunde und Geburtshilfe, Universitätsklinikum Bonn, Bonn.
Abteilung für Geburtshilfe und Pränatale Medizin, Universitätsklinikum Bonn, Bonn, Germany.
Abteilung für Anästhesiologie, Intensiv- und Notfallmedizin, Diakonie Klinikum Jung-Stilling, Siegen, Germany.
AN  - 33012834
AU  - Recker, F.
AU  - Weber, E.
AU  - Strizek, B.
AU  - Gembruch, U.
AU  - Seibel, A.
C1  - 10/6/2020
C2  - PMC7518931
DA  - Oct
DB  - PubMed
DO  - 10.1055/a-1228-4242
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Geburtshilfe und Frauenheilkunde
KW  - lung ultrasound scan
obstetrics
training
conflict of interest./Die Autorinnen/Autoren geben an, dass kein Interessenkonflikt
besteht.
LA  - eng
N1  - 1438-8804
Recker, Florian
Weber, Eva
Strizek, Brigitte
Gembruch, Ulrich
Seibel, Armin
Journal Article
Geburtshilfe Frauenheilkd. 2020 Oct;80(10):1026-1032. doi: 10.1055/a-1228-4242. Epub 2020 Sep 25.
PY  - 2020
SN  - 0016-5751 (Print)
0016-5751
SP  - 1026-1032
ST  - Lung Sonography in Obstetrics during COVID-19
T2  - Geburtshilfe und Frauenheilkunde
TI  - Lung Sonography in Obstetrics during COVID-19
VL  - 80
ID  - 7785553
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic is straining public health systems and the global economy, triggering unprecedented measures by governments around the globe. The adoption of a preventive measure is required to control the spread. This research explores the impact of influencing factors like COVID-19 knowledge, behavioral control, moral and subject norms, preventive e-guidelines by the government, and environmental factors on the intention to prevent COVID-19 and risk aversion. A cross-sectional study was performed of 310 respondents about different COVID-19 related influencing factors in Pakistan. The partial least square-structural equation modeling was applied to estimate the path coefficient. Moral and subject norms (0.359) had a comparatively higher path coefficient. Other influencing factors/drivers were preventive e-guideline by the government (0.215) followed by COVID-19 knowledge (0.197), and behavioral control (0.121). The intention to prevent COVID-19 showed a positive and significant impact (0.705) on risk aversion. The indirect analysis also confirmed that the positive influence of moral and subject norms, COVID-19 knowledge, preventive e-guideline by the government, and behavioral control on risk aversion. However, the path coefficient of environmental factors was negative but insignificant, which implies than environmental factors do not influence the intention to prevent COVID-19. It is suggested to provide clear guidelines using print, social, electronic media. It is also suggested to provide e-guidelines in local languages. The COVID-19 knowledge about its transmission, symptoms, and precautions is also useful. It is suggested to include the causes, symptoms, and precaution of viral diseases in the educational syllabus. The government should ensure the availability of preventive medical items like surgical masks and sanitizers to meet the demand of the public.
AD  - Department of Molecular Biology, Virtual University of Pakistan-Faisalabad Campus, Faisalabad, 38000, Pakistan.
Department of Economics, Virtual University of Pakistan-Faisalabad Campus, Faisalabad, 38000, Pakistan.
Department of Molecular Biology, Virtual University of Pakistan, -54000, Lahore, Pakistan. tanveer.hussain@vu.edu.pk.
AN  - 33011950
AU  - Raza, A.
AU  - Ali, Q.
AU  - Hussain, T.
C1  - 10/6/2020
C2  - PMC7532951
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s11356-020-10931-9
DP  - NLM
ET  - 2020/10/05
J2  - Environmental science and pollution research international
KW  - Behavior
COVID-19 knowledge
Environment
Pls-sem
Pandemic
SARS-CoV-2
LA  - eng
N1  - 1614-7499
Raza, Ali
Ali, Qamar
Hussain, Tanveer
Orcid: 0000-0002-2522-2406
Journal Article
Environ Sci Pollut Res Int. 2020 Oct 4:1-17. doi: 10.1007/s11356-020-10931-9.
PY  - 2020
SN  - 0944-1344 (Print)
0944-1344
SP  - 1-17
ST  - Role of knowledge, behavior, norms, and e-guidelines in controlling the spread of COVID-19: evidence from Pakistan
T2  - Environmental science and pollution research international
TI  - Role of knowledge, behavior, norms, and e-guidelines in controlling the spread of COVID-19: evidence from Pakistan
ID  - 7785641
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) is a highly infectious disease caused by the severe acute respiratory syndrome coronavirus 2 virus (SARS-CoV-2). While children appear to experience less severe disease than adults, those with underlying conditions such as kidney disease may be more susceptible to infection. Limited data are present for children with kidney disease, and there are limited prior reports of pediatric hemodialysis patients with COVID-19. This report describes the mild clinical disease course of COVID-19 in two pediatric patients with chronic kidney disease, one on hemodialysis and both on chronic immunosuppression. We review treatment in these patients, as well as our measures to reduce transmission among our hemodialysis patients and staff.
AD  - Division of Nephrology, Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
Division of Infectious Diseases, Department of Pediatrics, Indiana University, Indianapolis, Indiana, USA.
AN  - 33015942
AU  - Rawson, A.
AU  - Wilson, A. C.
AU  - Schwaderer, A. L.
AU  - Spiwak, E.
AU  - Johnston, B.
AU  - Anderson, S.
AU  - Nailescu, C.
AU  - Gupta, S.
AU  - Christenson, J. C.
AU  - Hains, D. S.
AU  - Starr, M. C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/hdi.12876
DP  - NLM
ET  - 2020/10/06
J2  - Hemodialysis international. International Symposium on Home Hemodialysis
KW  - Coronavirus
SARS-CoV-2
end-stage kidney disease
hemodialysis
pediatrics
LA  - eng
N1  - 1542-4758
Rawson, Ashley
Wilson, Amy C
Schwaderer, Andrew L
Spiwak, Elizabeth
Johnston, Bethanne
Anderson, Shannon
Nailescu, Corina
Gupta, Sushil
Christenson, John C
Hains, David S
Starr, Michelle C
Orcid: 0000-0001-9412-8950
T32DK120524/DK/NIDDK NIH HHS/United States
Case Reports
Canada
Hemodial Int. 2020 Oct 5. doi: 10.1111/hdi.12876.
PY  - 2020
SN  - 1492-7535
ST  - Coronavirus disease 2019 (COVID-19) in two pediatric patients with kidney disease on chronic immunosuppression: A case series
T2  - Hemodialysis international International Symposium on Home Hemodialysis
TI  - Coronavirus disease 2019 (COVID-19) in two pediatric patients with kidney disease on chronic immunosuppression: A case series
ID  - 7785232
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The ongoing pandemic of COVID-19 has led to severe disruption of healthcare services worldwide. We conducted this study to assess the impact of COVID-19 pandemic on the management of Systemic Lupus Erythematosus (SLE) patients who were enrolled in the nation-wide inception cohort. METHODS: A questionnaire was administered to the SLE patients enrolled in the inception cohort. Questions related to the effect on disease activity, preventive measures adopted against COVID-19, the incidence of COVID-19, hardships faced in getting access to health care professionals and availability of medicines, adherence, fear of COVID-19 and the potential benefits of being part of the registry. RESULTS: A total of 1040 (90% females) patients completed the questionnaire. The mean age was 27.5 ±�?9.1 years and the mean disease duration was 1.25 years. Twenty-Four (2.3%) patients had developed fever (1 day) during this period, including one patient with additional symptoms of diarrhoea and anosmia, however, none of the patients developed COVID-19 infection. 262 patients (25.2%) reported financial difficulty during this period and patients reported an average excess expenditure of at least 2255.45 INR ($30) per month. 378 patients (36%) reported problems in getting their prescribed medicines due to lockdown. Of these, 167 (40%) patients needed to change their medication schedule due to this non-availability. Almost 54% of patients missed their scheduled follow up visits during the lockdown period and 37% of patients were unable to get their investigations done due to closure of laboratories and hospitals. 266 patients (25.5%) reported worsening of various symptoms of SLE during this period. Almost 61% patients felt confident that being associated with the inception cohort had helped them in managing their disease better during this period of lockdown as they received help in the form of timely and frequent telephonic consults, assistance in making the medicines available, and regular counselling resulting in abetment of their fears and anxieties. CONCLUSION: The current COVID-19 pandemic has made a huge impact on our SLE patients. Patients faced difficulty in the availability of medicines, missed the doses of medicines, had financial constraints, and spent more money on health during the pandemic.
AD  - Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Rheumatology, Nizam Institute of Medical Sciences, Hyderabad, India.
Department of Clinical Immunology and Rheumatology, St John's Medical College Hospital, Bengaluru, India.
Department of Clinical Immunology, JIPMER, Puducherry, India.
Department of Rheumatology, SCB Medical College, Cuttack, Inida.
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, India.
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India.
Department of Medicine, Division of Clinical Immunology and Rheumatology, SMS Medical College, Jaipur, India.
AN  - 33019877
AU  - Rathi, M.
AU  - Singh, P.
AU  - Bi, H. P.
AU  - Shivanna, A.
AU  - Kavadichanda, C.
AU  - Tripathy, S. R.
AU  - Parthasarathy, J.
AU  - Tota, S.
AU  - Maurya, S.
AU  - Vijayalekshmi, V.
AU  - Bhavani, D.
AU  - Jain, A.
AU  - Gupta, R.
AU  - Danda, D.
AU  - Rajasekhar, L.
AU  - Negi, V. S.
AU  - Shobha, V.
AU  - Das, B.
AU  - Aggarwal, A.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/0961203320962855
DP  - NLM
ET  - 2020/10/07
J2  - Lupus
KW  - Cohort
Corona virus
Hydroxychloroquine
pandemic
LA  - eng
N1  - 1477-0962
Rathi, Manish
Orcid: 0000-0002-2642-8895
Singh, Parmeshar
Bi, Hayath Peta
Shivanna, Archana
Kavadichanda, Chengappa
Tripathy, Saumya Ranjan
Parthasarathy, Janani
Tota, Sneha
Maurya, Supriya
Vijayalekshmi, Vishnupriya
Bhavani, D
Jain, Avinash
Gupta, Ranjan
Orcid: 0000-0003-3965-5410
Danda, Debashish
Orcid: 0000-0002-8751-2724
Rajasekhar, Liza
Negi, Vir Singh
Orcid: 0000-0002-9548-7725
Shobha, Vineeta
Das, Bidyut
Aggarwal, Amita
Orcid: 0000-0002-2187-5186
Journal Article
England
Lupus. 2020 Oct 6:961203320962855. doi: 10.1177/0961203320962855.
PY  - 2020
SN  - 0961-2033
SP  - 961203320962855
ST  - Impact of the COVID-19 pandemic on patients with systemic lupus erythematosus: Observations from an Indian inception cohort
T2  - Lupus
TI  - Impact of the COVID-19 pandemic on patients with systemic lupus erythematosus: Observations from an Indian inception cohort
ID  - 7785078
ER  - 

TY  - JOUR
AB  - Objective: To evaluate if the number of admitted extremely preterm (EP) infants (born before 28weeks of gestational age) has changed in the neonatal intensive care units (NICUs) of the SafeBoosC-III consortium during the global lockdown when compared to the corresponding time period in 2019. Design: This is a retrospective, observational study. Forty-six out of 79 NICUs (58%) from 17 countries participated. Principal investigators were asked to report the following information: 1) Total number of EP infant admissions to their NICU in the three months where the lockdown restrictions were most rigorous during the first phase of the COVID-19 pandemic, 2) Similar EP infant admissions in the corresponding three months of 2019, 3) the level of local restrictions during the lockdown period and 4) the local impact of the COVID-19 lockdown on the everyday life of a pregnant woman. Results: There was no significant difference between the number of EP infant admissions during the three most rigorous lockdown months of the COVID-19 pandemic compared to the corresponding three months in 2019 (n=428 versus n=457 respectively, p=0.33). There were no significant changes within individual geographic regions and no significant association between the level of lockdown restrictions and change in the number of EP infant admissions (p=0.334). Conclusion: This larger ad hoc study did not confirm previous studies report of a major reduction in the number of extremely preterm births during the first phase of the COVID-19 pandemic.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT04527601Clinical Protocolshttps://clinicaltrials.gov/ct2/show/NCT04527601Funding StatementThe sponsor/coordinating investigator, Professor of Paediatrics Gorm Greisen, is the initiator of the SafeBoosC-III project. He has no financial interest in the results of the trial. The Elsass Foundation, Aage and Johanne Louis-Hansen Foundation, and Svend Andersen Foundation supported the SafeBoosC-III trial through unconditional and unrestricted grants of DKK 2,700,000, DKK 1,000,000 and DKK 1,000,000, respectively. These funding sources had no role in the design of this study and will not have any role during its execution, analysis, interpretation of the data or decision to submit results.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:According to Danish law, ethical permission to conduct this study was not necessary.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe datasets used and/or analysed during the current study are available from the corresponding author on request and will be published on www.safeboosc.eu
AU  - Rasmussen, Marie Isabel
AU  - Hansen, Mathias Luehr
AU  - Pichler, Gerhard
AU  - Dempsey, Eugene
AU  - Pellicer, Adelina
AU  - El-Khuffash, Afif
AU  - A, Shashidhar
AU  - Piris-Borregas, Salvador
AU  - Alsina, Miguel
AU  - Cetinkaya, Merih
AU  - Chalak, Lina
AU  - Ozkan, Hilal
AU  - Baserga, Mariana
AU  - Sirc, Jan
AU  - Fuchs, Hans
AU  - Ergenekon, Ebru
AU  - Arruza, Luis
AU  - Mathur, Amit
AU  - Stocker, Martin
AU  - Otero-Vaccarello, Olalla
AU  - Szczapa, Tomasz
AU  - Sarafidis, Kosmas
AU  - Krolak-Olejnik, Barbara
AU  - Memisoglu, Asli
AU  - Reigstad, Hallvard
AU  - Rafinska-Wazny, Elzbieta
AU  - Hatzidaki, Eleftheria
AU  - Peng, Zhang
AU  - Gkentzi, Despoina
AU  - Viellevoye, Renaud
AU  - De Buyst, Julie
AU  - Mastretta, Emmanuele
AU  - Wang, Ping
AU  - Hahn, Gitte
AU  - Bender, Lars
AU  - Cornette, Luc
AU  - Tkaczyk, Jakub
AU  - del Rio, Ruth
AU  - Fumagalli, Monica
AU  - Papathoma, Evangelina
AU  - Wilinska, Maria
AU  - Naulers, Gunnar
AU  - Sadowska-Kakrawczenko, Iwona
AU  - Lecart, Chantal
AU  - Couce, Maria Luz
AU  - Fredly, Siv
AU  - Heuchan, Anne Marie
AU  - Karen, Tanja
AU  - Greisen, Gorm
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20204578
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20204578
ST  - Extremely preterm infant admissions within the SafeBoosC-III consortium during the COVID-19 lockdown (preprint)
T2  - medRxiv
TI  - Extremely preterm infant admissions within the SafeBoosC-III consortium during the COVID-19 lockdown (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20204578.abstract
ID  - 7788869
ER  - 

TY  - JOUR
AB  - We read with great interest the letter by Leocani and coworkers "Disability through COVID-19 pandemic: neurorehabilitation cannot wait". We agree with their report of how the COVID-19 epidemic countermeasures affected Neurorehabilitation facilities in Italy (1) and we endorse the Authors' position concerning the importance of providing timely disability management even in the pandemic phase. At the same time, given the necessity to adapt protections from COVID-19 exposure for patients and staff, multidisciplinary teams have to reorganize work routine with the support of digital technology .
AD  - Rehabilitation Medicine Unit, Geriatric and Rehabilitation Department, University Hospital of Parma, Italy, Parma.
AN  - 33012098
AU  - Ranza, E.
AU  - Mammi, P.
AU  - Rampello, A.
AU  - Salghetti, A.
AU  - Brianti, R.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/ene.14569
DP  - NLM
ET  - 2020/10/05
J2  - European journal of neurology
KW  - Botulinum toxin therapy
covid19
neurorehabilitation
physiatry
LA  - eng
N1  - 1468-1331
Ranza, Elena
Orcid: 0000-0002-9018-0468
Mammi, Patrizia
Rampello, Anais
Salghetti, Annamaria
Brianti, Rodolfo
Journal Article
England
Eur J Neurol. 2020 Oct 4. doi: 10.1111/ene.14569.
PY  - 2020
SN  - 1351-5101
ST  - Botulinum toxin therapy during the Covid 19 outbreak: Experience of an Italian multidisciplinary team
T2  - European journal of neurology
TI  - Botulinum toxin therapy during the Covid 19 outbreak: Experience of an Italian multidisciplinary team
ID  - 7785622
ER  - 

TY  - JOUR
AB  - Purpose: We respond to calls from business schools (B-schools), apex education bodies, regulators, activist groups and researchers for more rigorous research to understand the future strategies of B-schools in India. We specifically examine the challenges posed by the current COVID-19 pandemic (and possible future similar eventualities) and the current and long-term strategies being planned to combat such crises. Design/methodology/approach: To reveal the real-life scenario, semi-structured interviews were conducted with 22 academic leaders (Deans and Directors) of B-schools in India. These respondents were from both public and private institutions across the country. Open-ended questions were framed for exploration to help the authors understand the way forward in the Indian B-school context. Findings: Findings reveal that B-schools in India are preparing themselves to overcome short-term challenges faced due to COVID-19 as well as transforming themselves through long-term strategies. Originality/value: The study outlines strategic plans for some imaginative reassessments that B-schools may consider as a reaction to a pandemic-like emergency. The focus is on distinguishing the imperatives, creating a key guide for meeting immediate requirements, allotting assets in a prudent way to update educational course curricula and teaching methods and building the required academic infrastructure. The ability to focus on enduring changes (e.g. creating an e-learning framework and providing a safe and secure learning environment to students as per government mandates) will provide B-schools with a new lease of life in the future. © 2020, Emerald Publishing Limited.
AD  - Fortune Institute of International Business, New Delhi, India
Indian Institute of Management (IIM) Raipur, Raipur, India
College of Healthcare Management and Economics, Gulf Medical University, Ajman, United Arab Emirates
AU  - Rana, S.
AU  - Anand, A.
AU  - Prashar, S.
AU  - Haque, M. M.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1108/IJOEM-04-2020-0415
J2  - Int. J. Emerg. Mark.
KW  - Business schools
COVID-19
India
Pandemic
Strategy
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Rana, S.; Fortune Institute of International BusinessIndia; email: rana.sudheer21@gmail.com
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PY  - 2020
SN  - 17468809 (ISSN)
ST  - A perspective on the positioning of Indian business schools post COVID-19 pandemic
T2  - International Journal of Emerging Markets
TI  - A perspective on the positioning of Indian business schools post COVID-19 pandemic
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091733845&doi=10.1108%2fIJOEM-04-2020-0415&partnerID=40&md5=25dd0a87aded92cd542de8cac313a084
ID  - 7783309
ER  - 

TY  - JOUR
AD  - Department of Pediatrics, Xinhua Hospital Affiliated to the Shanghai Jiao Tong University School of Medicine, Shanghai, China.
University Iberoamericana UNIBE School of Medicine, Santo Domingo, The Dominican Republic.
Department of Medicine, Sir Seewoosagur Ramgoolam National Hospital, Pamplemousses, Mauritius.
AN  - 33014228
AU  - Ramphul, K.
AU  - Mejias, S. G.
AU  - Ramphul, Y.
C1  - 10/6/2020
C2  - PMC7517395
DB  - PubMed
DO  - 10.5847/wjem.j.1920-8642.2020.04.014
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - World journal of emergency medicine
LA  - eng
N1  - Ramphul, Kamleshun
Mejias, Stephanie G
Ramphul, Yogeshwaree
Journal Article
World J Emerg Med. 2020;11(4):274. doi: 10.5847/wjem.j.1920-8642.2020.04.014.
PY  - 2020
SN  - 1920-8642 (Print)
1920-8642
SP  - 274
ST  - Headache may not be linked with severity of coronavirus disease 2019 (COVID-19)
T2  - World journal of emergency medicine
TI  - Headache may not be linked with severity of coronavirus disease 2019 (COVID-19)
VL  - 11
ID  - 7785412
ER  - 

TY  - JOUR
AB  - Homeless persons and migrants in precarious housing conditions are vulnerable populations that have been peculiarly impacted by the Coronavirus Disease 19 (COVID-19) pandemic. These populations are more at risk of contracting COVID-19 as they often find it difficult to adhere to public health directives and, if exposed, may be more susceptible to illness or death due to the higher prevalence of underlying physical and mental comorbidities compared to the general population. In addition, vulnerable populations may have limited access to essential diagnostics and treatments, thus leading to untreated COVID-19 cases and their development into more severe forms. Health, social and government agencies should collaborate to develop services that support these communities, in accordance with the World Health Organization principles. Migrant and homeless centers have a central role, as they provide a significant contribution to prevent infection spread and favor access to early medical treatment to those affected, thus preventing more severe forms of infection.
AD  - Department of Sense Organs, Sapienza University of Rome, Rome, Italy. massimo.ralli@uniroma1.it.
AN  - 33015824
AU  - Ralli, M.
AU  - Cedola, C.
AU  - Urbano, S.
AU  - Morrone, A.
AU  - Ercoli, L.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23071
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Ralli, M
Cedola, C
Urbano, S
Morrone, A
Ercoli, L
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9765-9767. doi: 10.26355/eurrev_202009_23071.
PY  - 2020
SN  - 1128-3602
SP  - 9765-9767
ST  - Homeless persons and migrants in precarious housing conditions and COVID-19 pandemic: peculiarities and prevention strategies
T2  - European review for medical and pharmacological sciences
TI  - Homeless persons and migrants in precarious housing conditions and COVID-19 pandemic: peculiarities and prevention strategies
VL  - 24
ID  - 7785241
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Since the COVID-19 outbreak, otolaryngologists, ophthalmologists and dentists have been severely affected, both for the transmission routes and for the diagnostical and therapeutic procedures typical of these disciplines. MATERIALS AND METHODS: In this article, we discuss the transmission routes, the potential risk of contagion for patients and healthcare providers during procedures, and comment on the changes that will affect head and neck clinical practice in the future of outpatient and surgical activities. RESULTS: Otolaryngologists, ophthalmologists and dentists are at high risk for infection contagion and spread because they perform diagnostic and therapeutic procedures that generate aerosol and droplets thus facilitating virus transmission. Furthermore, examination involves close doctor-patient contact and otolaryngologists and dentists have to remove patient's protective devices during the visit. CONCLUSIONS: Special attention to prevention protocols for diagnostic and therapeutic procedures and the use of protective equipment is of utmost importance to limit contagion and prevent a new virus spread in the near future.
AD  - Department of Sense Organs, Sapienza University of Rome, Rome, Italy. massimo.ralli@uniroma1.it.
AN  - 33015816
AU  - Ralli, M.
AU  - Candelori, F.
AU  - Cambria, F.
AU  - Greco, A.
AU  - Angeletti, D.
AU  - Lambiase, A.
AU  - Campo, F.
AU  - Minni, A.
AU  - Polimeni, A.
AU  - de Vincentiis, M.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23062
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Ralli, M
Candelori, F
Cambria, F
Greco, A
Angeletti, D
Lambiase, A
Campo, F
Minni, A
Polimeni, A
de Vincentiis, M
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9705-9711. doi: 10.26355/eurrev_202009_23062.
PY  - 2020
SN  - 1128-3602
SP  - 9705-9711
ST  - Impact of COVID-19 pandemic on otolaryngology, ophthalmology and dental clinical activity and future perspectives
T2  - European review for medical and pharmacological sciences
TI  - Impact of COVID-19 pandemic on otolaryngology, ophthalmology and dental clinical activity and future perspectives
VL  - 24
ID  - 7785248
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The World Health Organization declared COVID-19 a pandemic on March 11, 2020. The virus that causes COVID-19 was designated as severe acute respiratory syndrome corona virus 2 (SARS-CoV-2). Several studies have reported chemosensory dysfunction, such as anosmia and ageusia, as common findings in COVID-19 positive patients. To date, qualitative olfactory testing has been performed only in a very few cohort studies on COVID-19 patients. However, objective testing is necessary to verify or determine the true magnitude of their deficits. Moreover, the proportion of COVID-19 patients exhibiting true olfactory disturbances is unknown. AIM OF THE STUDY: To determine the true prevalence of olfactory dysfunction in COVID-19 patients by objective assessment in mild to moderate symptomatic patients. MATERIALS & METHODOLOGY: This was a prospective cross-sectional analytical study. All patients who were COVID-19 positive and having mild to moderate symptoms and not admitted in ICU formed part of the study group. Objective evaluation of smell function was done. RESULTS: Self-reported smell dysfunction was present in 26.9% patients (n=62) and taste dysfunction was seen in 10.9% (n=25) of patients. On quantitative assessment of smell dysfunction, it was noted that 41.3% (n=95) of patients had some form of smell dysfunction out of which 70.5% patients (n=67) had hyposmia and 29.5% patients (n=28) had anosmia. CONCLUSION: Incidence was found to be more by objective assessment when compared to self-reported symptoms.
AD  - Department of ENT-HNS, Saveetha Medical College and Hospital, No. 1 Saveetha Nagar, Thandalam, Chennai, 602105 Tamil Nadu India.
AN  - 33020732
AU  - Rajkumar, I.
AU  - Anand, K. H.
AU  - Revathishree, K.
AU  - Shoba, K.
AU  - Srinivasan, K.
C1  - 10/6/2020
C2  - PMC7526965
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s12070-020-02175-3
DP  - NLM
ET  - 2020/10/07
J2  - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
KW  - Covid-19
Incidence
Keywords
Objective
Olfactory disturbance
Self-reported
Subjective
LA  - eng
N1  - Rajkumar, Indu
Orcid: 0000-0002-5640-3787
Anand, K H
Revathishree, K
Shoba, K
Srinivasan, K
Journal Article
India
Indian J Otolaryngol Head Neck Surg. 2020 Sep 30:1-5. doi: 10.1007/s12070-020-02175-3.
PY  - 2020
SN  - 2231-3796 (Print)
2231-3796
SP  - 1-5
ST  - Contemporary Analysis of Olfactory Dysfunction in Mild to Moderate Covid 19 Patients in A Tertiary Health Care Centre
T2  - Indian journal of otolaryngology and head and neck surgery : official publication of Association of Otolaryngologists of India
TI  - Contemporary Analysis of Olfactory Dysfunction in Mild to Moderate Covid 19 Patients in A Tertiary Health Care Centre
ID  - 7784992
ER  - 

TY  - JOUR
AB  - The novel coronavirus disease of 2019 (COVID-19) is caused by the binding of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) to angiotensin-converting enzyme 2 (ACE2) receptors present on various locations such as the pulmonary alveolar epithelium and vascular endothelium. In COVID-19 patients, the interaction of SARS-CoV-2 with these receptors in the cerebral blood vessels has been attributed to stroke. Although the incidence of acute ischemic stroke is relatively low, ranging from 1% to 6%, the mortality associated with it is substantially high, reaching as high as 38%. This case series describes three distinct yet similar scenarios of COVID-19 positive patients with several underlying comorbidities, wherein two of the patients presented to our hospital with sudden onset right-sided weakness, later diagnosed with ischemic stroke, and one patient who developed an acute intracerebral hemorrhage during his hospital stay. The patients were diagnosed with acute stroke as a complication of COVID-19 infection. We also provide an insight into the possible mechanisms responsible for the life-threatening complication. Physicians should have a low threshold for suspecting stroke in COVID-19 patients, and close observation should be kept on such patients particularly those with clinical evidence of traditional risk factors.
AD  - Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, USA.
Internal Medicine, University College of Medical Sciences, Delhi, IND.
Internal Medicine, University of Nebraska Medical Center, Omaha, USA.
AN  - 33014653
AU  - Rajdev, K.
AU  - Lahan, S.
AU  - Klein, K.
AU  - Piquette, C. A.
AU  - Thi, M.
C1  - 10/6/2020
C2  - PMC7526955
DA  - Aug 31
DB  - PubMed
DO  - 10.7759/cureus.10157
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Cureus
KW  - co-morbidity
complication
covid-19
intracerebral hemorrhage
mortality
stroke
LA  - eng
N1  - 2168-8184
Rajdev, Kartikeya
Lahan, Shubham
Klein, Kate
Piquette, Craig A
Thi, Meilinh
Case Reports
Cureus. 2020 Aug 31;12(8):e10157. doi: 10.7759/cureus.10157.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10157
ST  - Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence
T2  - Cureus
TI  - Acute Ischemic and Hemorrhagic Stroke in COVID-19: Mounting Evidence
VL  - 12
ID  - 7785378
ER  - 

TY  - JOUR
AB  - In this review article, we have presented a detailed analysis of the recent advancement of quantum mechanical calculations in the applications of the low-dimensional nanomaterials (LDNs) into biomedical fields like biosensors and drug delivery systems development. Biosensors play an essential role for many communities, e.g. law enforcing agencies to sense illicit drugs, medical communities to remove overdosed medications from the human and animal body etc. Besides, drug delivery systems are theoretically being proposed for many years and experimentally found to deliver the drug to the targeted sites by reducing the harmful side effects significantly. In current COVID-19 pandemic, biosensors can play significant roles, e.g. to remove experimental drugs during the human trials if they show any unwanted adverse effect etc. where the drug delivery systems can be potentially applied to reduce the side effects. But before proceeding to these noble and expensive translational research works, advanced theoretical calculations can provide the possible outcomes with considerable accuracy. Hence in this review article, we have analyzed how theoretical calculations can be used to investigate LDNs as potential biosensor devices or drug delivery systems. We have also made a very brief discussion on the properties of biosensors or drug delivery systems which should be investigated for the biomedical applications and how to calculate them theoretically. Finally, we have made a detailed analysis of a large number of recently published research works where theoretical calculations were used to propose different LDNs for bio-sensing and drug delivery applications.
AD  - Department of Physics, Jahangirnagar University, Savar, Dhaka 1342, Bangladesh.
Department of Physics, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.
AN  - 33012931
AU  - Rahman, H.
AU  - Hossain, M. R.
AU  - Ferdous, T.
C1  - 10/6/2020
C2  - PMC7525470
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.molliq.2020.114427
DP  - NLM
ET  - 2020/10/06
J2  - Journal of molecular liquids
KW  - Boron nitride
Dft
Drug delivery
Drug sensing
Graphene
Review
personal relationships that could have appeared to influence the work reported in
this paper.
LA  - eng
N1  - 1873-3166
Rahman, Hamidur
Hossain, Md Rakib
Ferdous, Tahmina
Journal Article
Review
J Mol Liq. 2020 Sep 30:114427. doi: 10.1016/j.molliq.2020.114427.
PY  - 2020
SN  - 0167-7322 (Print)
0167-7322
SP  - 114427
ST  - The recent advancement of low-dimensional nanostructured materials for drug delivery and drug sensing application: A brief review
T2  - Journal of molecular liquids
TI  - The recent advancement of low-dimensional nanostructured materials for drug delivery and drug sensing application: A brief review
ID  - 7785531
ER  - 

TY  - JOUR
AB  - Although Kerala was the first state in India to report COVID cases, it was well prepared drawing on its past experience in managing effectively the Nipah outbreak and Kerala floods It knew and initiated the measures required for containment because of its prior experience with mobilizing community-based groups, involvement of local-self government in decentralized planning, and participation in the containment and relief measure as well as a system-ready health system and infrastructure The measures taken to &quot;flatten the curve&quot; that is unique to Kerala and the determinants of success are described in detail as &quot;what worked&quot; using the framework we developed post the Nipah outbreak containment experience These are being shared with the hope that the insights these measures undertaken by the state provide can be used elsewhere to translate and replicate components that work
AU  - Rahim, Asma Ayesha
AU  - Chacko, Thomas V.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Replicating the Kerala state's successful COVID-19 containment model: Insights on what worked
T2  - Indian Journal of Community Medicine
TI  - Replicating the Kerala state's successful COVID-19 containment model: Insights on what worked
UR  - https://doi.org/10.4103/ijcm.IJCM_598_20
ID  - 7788395
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19) pandemic is straining public health systems worldwide, and major non-pharmaceutical interventions have been implemented to slow its spread(1-4). During the initial phase of the outbreak, dissemination of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was primarily determined by human mobility from Wuhan, China(5,6). Yet empirical evidence on the effect of key geographic factors on local epidemic transmission is lacking(7). In this study, we analyzed highly resolved spatial variables in cities, together with case count data, to investigate the role of climate, urbanization and variation in interventions. We show that the degree to which cases of COVID-19 are compressed into a short period of time (peakedness of the epidemic) is strongly shaped by population aggregation and heterogeneity, such that epidemics in crowded cities are more spread over time, and crowded cities have larger total attack rates than less populated cities. Observed differences in the peakedness of epidemics are consistent with a meta-population model of COVID-19 that explicitly accounts for spatial hierarchies. We paired our estimates with globally comprehensive data on human mobility and predict that crowded cities worldwide could experience more prolonged epidemics.
AD  - Computational Epidemiology Lab, Boston Children's Hospital, Boston MA, USA.
Department of Epidemiology, Boston University School of Public Health, Boston MA, USA.
Network Science Institute, Northeastern University, Boston MA, USA. s.scarpino@northeastern.edu.
ISI Foundation, Turin, Italy. s.scarpino@northeastern.edu.
Santa Fe Institute, Santa Fe NM, USA. s.scarpino@northeastern.edu.
Program for Evolutionary Dynamics, Harvard University, Cambridge MA, USA.
Institute for Computational Medicine, Johns Hopkins University, Baltimore MD, USA.
Department of Health Metrics, University of Washington, Seattle WA, USA.
Institute for Health Metrics and Evaluation, University of Washington, Seattle WA, USA.
Department of Zoology, University of Oxford, Oxford, UK.
School of Biological and Environmental Sciences, Universidad San Francisco de Quito USFQ, Quito, Ecuador.
Network Science Institute, Northeastern University, Boston MA, USA.
Harvard Medical School, Boston MA, USA.
Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston MA, USA.
State Key Laboratory of Remote Sensing Science, College of Global Change and Earth System Science, Beijing Normal University, Beijing, China.
Department of Zoology, University of Oxford, Oxford, UK. oliver.pybus@zoo.ox.ac.uk.
Department of Pathobiology and Population Science, The Royal Veterinary College, London, UK. oliver.pybus@zoo.ox.ac.uk.
Department of Zoology, University of Oxford, Oxford, UK. moritz.kraemer@zoo.ox.ac.uk.
AN  - 33020651
AU  - Rader, B.
AU  - Scarpino, S. V.
AU  - Nande, A.
AU  - Hill, A. L.
AU  - Adlam, B.
AU  - Reiner, R. C.
AU  - Pigott, D. M.
AU  - Gutierrez, B.
AU  - Zarebski, A. E.
AU  - Shrestha, M.
AU  - Brownstein, J. S.
AU  - Castro, M. C.
AU  - Dye, C.
AU  - Tian, H.
AU  - Pybus, O. G.
AU  - Kraemer, M. U. G.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1038/s41591-020-1104-0
DP  - NLM
ET  - 2020/10/07
J2  - Nature medicine
LA  - eng
N1  - 1546-170x
Rader, Benjamin
Orcid: 0000-0002-6095-0193
Scarpino, Samuel V
Orcid: 0000-0001-5716-2770
Nande, Anjalika
Orcid: 0000-0003-1726-6633
Hill, Alison L
Orcid: 0000-0002-6583-3623
Adlam, Ben
Reiner, Robert C
Orcid: 0000-0003-1056-7919
Pigott, David M
Orcid: 0000-0002-6731-4034
Gutierrez, Bernardo
Orcid: 0000-0002-9220-2739
Zarebski, Alexander E
Shrestha, Munik
Brownstein, John S
Orcid: 0000-0001-8568-5317
Castro, Marcia C
Orcid: 0000-0003-4606-2795
Dye, Christopher
Orcid: 0000-0002-2957-1793
Tian, Huaiyu
Pybus, Oliver G
Orcid: 0000-0002-8797-2667
Kraemer, Moritz U G
Orcid: 0000-0001-8838-7147
Journal Article
United States
Nat Med. 2020 Oct 5. doi: 10.1038/s41591-020-1104-0.
PY  - 2020
SN  - 1078-8956
ST  - Crowding and the shape of COVID-19 epidemics
T2  - Nature medicine
TI  - Crowding and the shape of COVID-19 epidemics
ID  - 7785019
ER  - 

TY  - JOUR
AB  - Epidemics and pandemics can traumatically impact the emotional wellbeing of adults, children, and adolescents in diverse ways. This impact can be reduced by applying a range of evidence-based coping strategies. Based on previous research, we created a pamphlet-based communication campaign designed to assist adults to provide support for young people confronted with emotional distress associated with the pandemic caused by the novel coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] and the related disease [coronavirus disease (COVID-19)] in 2020. We developed a pamphlet describing the common emotions children and adolescents report feeling in the face of disasters and the coping strategies that have proven effective in mitigating them. The target population was adults who interact with children and adolescents in both formal and informal settings. The pamphlet included basic information on this specific emergency, emotions that might be commonly experienced, and coping strategies for dealing with negative emotions. The aim of this paper is to describe the planning, development, and implementation of the campaign. First, we monitored how the media gave visibility to the campaign during the 40 days following the release of the pamphlet: it potentially reached a large audience at a national and international level through at least 216 media channels included the HEMOT(�]) (Helmet for EMOTions) website. Second, Google Analytics�?data from the HEMOT(�]) website enabled us to examine the characteristics of the visitors to the website and the behavior of those who viewed the pamphlet. More than 6,000 visitors, most from Europe followed by the Americas, visited the website in the first 40 days after the pamphlet publication. The webpage including the pamphlet obtained over 6,200 views, most directly or via other websites. A cluster analysis suggested that the access to the webpage did not mirror the trend concerning the new cases of COVID-19 in Italy (which increased during the central phase of the campaign) or worldwide (which continued to increase across the 40 days). Third, data gathered with a convenience sample of adults who had consulted the pamphlet provided a perspective on the comprehensibility of the messages conveyed by the pamphlet and on the utility for children and adolescents. The process we have demonstrated in this example could be replicated in different communities and settings to respond to the spread of the COVID-19 or to respond to other widespread or more localized disasters.
AD  - Department of Human Sciences, University of Verona, Verona, Italy.
Environmetrics Pty Ltd., Killara, NSW, Australia.
AN  - 33013563
AU  - Raccanello, D.
AU  - Vicentini, G.
AU  - Rocca, E.
AU  - Barnaba, V.
AU  - Hall, R.
AU  - Burro, R.
C1  - 10/6/2020
C2  - PMC7511710
DB  - PubMed
DO  - 10.3389/fpsyg.2020.02184
DP  - NLM
ET  - 2020/10/06
J2  - Frontiers in psychology
KW  - adolescents
children
communication campaign
coping strategies
coronavirus
emotions
LA  - eng
N1  - 1664-1078
Raccanello, Daniela
Vicentini, Giada
Rocca, Emmanuela
Barnaba, Veronica
Hall, Rob
Burro, Roberto
Journal Article
Front Psychol. 2020 Sep 10;11:2184. doi: 10.3389/fpsyg.2020.02184. eCollection 2020.
PY  - 2020
SN  - 1664-1078 (Print)
1664-1078
SP  - 2184
ST  - Development and Early Implementation of a Public Communication Campaign to Help Adults to Support Children and Adolescents to Cope With Coronavirus-Related Emotions: A Community Case Study
T2  - Frontiers in psychology
TI  - Development and Early Implementation of a Public Communication Campaign to Help Adults to Support Children and Adolescents to Cope With Coronavirus-Related Emotions: A Community Case Study
VL  - 11
ID  - 7785450
ER  - 

TY  - JOUR
AB  - INTRODUCTION: During the COVID-19 pandemic, hospitals faced increasing pressure, where people living with HIV risked to either acquire SARS-CoV-2 and to interrupt the HIV continuum of care. METHODS: This is a retrospective, observational study. We compared the numbers of medical visits performed, antiretroviral drugs dispensed and the number of new HIV diagnosis and of hospitalizations in a cohort of people living with HIV (PLWH) followed by the Spedali Civili of Brescia between the bimester of the COVID-19 pandemic peak and the bimester of October-November 2019. Data were retrieved from administrative files and from paper and electronic clinical charts. Categorical variables were described using frequencies and percentages, while continuous variables were described using mean, median, and interquartile range (IQR) values. Means for continuous variables were compared using Student's t-tests and the Mann-Whitney test. Proportions for categorical variables were compared using the χ(2) test. RESULTS: As of December 31st, 2019, a total of 3875 PLWH were followed in our clinic. Mean age was 51.4 ±�?3 years old, where 28% were females and 18.8% non-Italian. Overall, 98.9% were on ART (n�?�?834), 93% were viro-suppressed. A total of 1217 and 1162 patients had their visit scheduled at our out-patient HIV clinic during the two bimesters of 2019 and 2020, respectively. Comparing the two periods, we observed a raise of missed visits from 5 to 8% (p �?.01), a reduction in the number of new HIV diagnosis from 6.4 in 2019 to 2.5 per month in 2020 (p�?�?.01), a drop in ART dispensation and an increase of hospitalized HIV patients due to COVID-19. ART regimens including protease inhibitors (PIs) had a smaller average drop than ART not including PIs (16.6 vs 21.6%, p �?.05). Whether this may be due to the perception of a possible efficacy of PIs on COVID19 is not known. CONCLUSIONS: Our experience highlights the importance of a resilient healthcare system and the need to implement new strategies in order to guarantee the continuum of HIV care even in the context of emergency.
AD  - Department of Infectious Diseases, University of Brescia, Brescia, Italy.
Division of Infectious Diseases, ASST Spedali Civili, Brescia, Italy.
Department of Infectious Diseases, University of Brescia, Brescia, Italy. magropao@gmail.com.
Division of Infectious Diseases, ASST Spedali Civili, Brescia, Italy. magropao@gmail.com.
Central Pharmacy, ASST Spedali Civili, Brescia, Italy.
AN  - 33012282
AU  - Quiros-Roldan, E.
AU  - Magro, P.
AU  - Carriero, C.
AU  - Chiesa, A.
AU  - El Hamad, I.
AU  - Tratta, E.
AU  - Fazio, R.
AU  - Formenti, B.
AU  - Castelli, F.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1186/s12981-020-00314-y
DP  - NLM
ET  - 2020/10/06
IS  - 1
J2  - AIDS research and therapy
KW  - Adherence
Covid-19
Follow-up
HIV continuum of care
Public health
SARS-CoV-2
LA  - eng
N1  - 1742-6405
Quiros-Roldan, Eugenia
Magro, Paola
Orcid: 0000-0001-7660-161x
Carriero, Canio
Chiesa, Annacarla
El Hamad, Issa
Tratta, Elena
Fazio, Raffaella
Formenti, Beatrice
Castelli, Francesco
Journal Article
England
AIDS Res Ther. 2020 Oct 4;17(1):59. doi: 10.1186/s12981-020-00314-y.
PY  - 2020
SN  - 1742-6405
SP  - 59
ST  - Consequences of the COVID-19 pandemic on the continuum of care in a cohort of people living with HIV followed in a single center of Northern Italy
T2  - AIDS research and therapy
TI  - Consequences of the COVID-19 pandemic on the continuum of care in a cohort of people living with HIV followed in a single center of Northern Italy
VL  - 17
ID  - 7785604
ER  - 

TY  - JOUR
AB  - Anti-melanoma differentiation-associated gene 5 juvenile dermatomyositis (anti-MDA5 JDM) is associated with high risk of developing rapidly progressive interstitial lung disease (RP-ILD). Here we report an 11-year-old girl with anti-MDA5 JDM and RP-ILD which led to a fatal outcome, further aggravated by SARS-CoV-2 infection. She was referred to our hospital after being diagnosed with anti-MDA5 JDM and respiratory failure due to RP-ILD. On admission, fibrobronchoscopy with bronchoalveolar lavage (BAL) revealed Pneumocystis jirovecii infection so treatment with intravenous trimethoprim-sulfamethoxazole was initiated. Due to RP-ILD worsening, immunosuppressive therapy was intensified using methylprednisolone pulses, cyclophosphamide, tofacitinib and intravenous immunoglobulin without response. She developed severe hypoxemic respiratory failure, pneumomediastinum and pneumothorax, further complicated with severe RP-ILD and cervical subcutaneous emphysema. Three real-time RT-PCR for SARS-CoV-2 were made with a negative result. In addition, she was complicated with a secondary hemophagocytic lymphohistiocytosis and a fourth real-time PCR for SARS-CoV-2 performed in BAS sample was positive. Despite aggressive treatment of RP-ILD due to anti-MDA5 JDM, there was no improvement of respiratory failure in the following days and patient developed refractory septic shock and died.Anti-MDA5 JDM patients with RP-ILD have a poor prognosis with a high mortality rate. For this reason, intensive immunosuppressive therapy is essential including the use of promising drugs such as tofacitinib. COVID-19 in children with underlying health conditions like anti-MDA5 JDM, may still be at risk for disease and severe complications.
AD  - Pediatric Rheumatology Department, La Paz Children´s Hospital, Madrid, Spain.
Pediatric Pulmonology Department, La Paz Children´s Hospital, Madrid, Spain.
Pediatric Intensive Care Unit, La Paz Children´s Hospital, Madrid, Spain.
AN  - 33019894
AU  - Quintana-Ortega, C.
AU  - Remesal, A.
AU  - Ruiz de Valbuena, M.
AU  - de la Serna, O.
AU  - Laplaza-Gonz֙lez, M.
AU  - Álvarez-Rojas, E.
AU  - Udaondo, C.
AU  - Alcobendas, R.
AU  - Murias, S.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/24725625.2020.1832755
DP  - NLM
ET  - 2020/10/07
J2  - Modern rheumatology case reports
KW  - Anti-MDA5
Covid-19
interstitial lung disease (ILD)
juvenile dermatomyositis
tofacitinib
LA  - eng
N1  - 2472-5625
Quintana-Ortega, Cristian
Orcid: 0000-0003-1680-3599
Remesal, Agust�Tn
Ruiz de Valbuena, Marta
de la Serna, Olga
Laplaza-Gonz֙lez, Mar�Ta
Álvarez-Rojas, Elena
Udaondo, Clara
Alcobendas, Rosa
Murias, Sara
Journal Article
England
Mod Rheumatol Case Rep. 2020 Oct 6:1-16. doi: 10.1080/24725625.2020.1832755.
PY  - 2020
SN  - 2472-5625
SP  - 1-16
ST  - Fatal outcome of anti-MDA5 juvenile dermatomyositis in a pediatric COVID-19 patient: a case report
T2  - Modern rheumatology case reports
TI  - Fatal outcome of anti-MDA5 juvenile dermatomyositis in a pediatric COVID-19 patient: a case report
ID  - 7785075
ER  - 

TY  - JOUR
AB  - BACKGROUND: Many low- and middle-income countries have implemented control measures against coronavirus disease 2019 (COVID-19). However, it is not clear to what extent these measures explain the low numbers of recorded COVID-19 cases and deaths in Africa. One of the main aims of control measures is to reduce respiratory pathogen transmission through direct contact with others. In this study, we collect contact data from residents of informal settlements around Nairobi, Kenya, to assess if control measures have changed contact patterns, and estimate the impact of changes on the basic reproduction number (R(0)). METHODS: We conducted a social contact survey with 213 residents of five informal settlements around Nairobi in early May 2020, 4 weeks after the Kenyan government introduced enhanced physical distancing measures and a curfew between 7 pm and 5 am. Respondents were asked to report all direct physical and non-physical contacts made the previous day, alongside a questionnaire asking about the social and economic impact of COVID-19 and control measures. We examined contact patterns by demographic factors, including socioeconomic status. We described the impact of COVID-19 and control measures on income and food security. We compared contact patterns during control measures to patterns from non-pandemic periods to estimate the change in R(0). RESULTS: We estimate that control measures reduced physical contacts by 62% and non-physical contacts by either 63% or 67%, depending on the pre-COVID-19 comparison matrix used. Masks were worn by at least one person in 92% of contacts. Respondents in the poorest socioeconomic quintile reported 1.5 times more contacts than those in the richest. Eighty-six percent of respondents reported a total or partial loss of income due to COVID-19, and 74% reported eating less or skipping meals due to having too little money for food. CONCLUSION: COVID-19 control measures have had a large impact on direct contacts and therefore transmission, but have also caused considerable economic and food insecurity. Reductions in R(0) are consistent with the comparatively low epidemic growth in Kenya and other sub-Saharan African countries that implemented similar, early control measures. However, negative and inequitable impacts on economic and food security may mean control measures are not sustainable in the longer term.
AD  - Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. matthew.quaife@lshtm.ac.uk.
Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK. matthew.quaife@lshtm.ac.uk.
Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Health Economics Research Unit, KEMRI-Wellcome Trust Research Programme, Nairobi, Kenya.
Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
Population Council, Nairobi, Kenya.
Population Council, New York, USA.
AN  - 33012285
AU  - Quaife, M.
AU  - van Zandvoort, K.
AU  - Gimma, A.
AU  - Shah, K.
AU  - McCreesh, N.
AU  - Prem, K.
AU  - Barasa, E.
AU  - Mwanga, D.
AU  - Kangwana, B.
AU  - Pinchoff, J.
AU  - Edmunds, W. J.
AU  - Jarvis, C. I.
AU  - Austrian, K.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1186/s12916-020-01779-4
DP  - NLM
ET  - 2020/10/06
IS  - 1
J2  - BMC medicine
KW  - Covid-19
Physical distancing
SARS-CoV-2
Social contacts
LA  - eng
N1  - 1741-7015
Quaife, Matthew
Orcid: 0000-0001-9291-1511
van Zandvoort, Kevin
Gimma, Amy
Shah, Kashvi
McCreesh, Nicky
Prem, Kiesha
Barasa, Edwine
Mwanga, Daniel
Kangwana, Beth
Pinchoff, Jessie
CMMID COVID-19 Working Group
Edmunds, W John
Jarvis, Christopher I
Austrian, Karen
INV-003174/Bill and Melinda Gates Foundation/
INV-001754/Bill and Melinda Gates Foundation/
221303/z/20/z/dfid/
757699/ERC_/European Research Council/International
101003688/Horizon 2020/
Es/p010873/1/ukri gcrf/
Journal Article
England
BMC Med. 2020 Oct 5;18(1):316. doi: 10.1186/s12916-020-01779-4.
PY  - 2020
SN  - 1741-7015
SP  - 316
ST  - The impact of COVID-19 control measures on social contacts and transmission in Kenyan informal settlements
T2  - BMC medicine
TI  - The impact of COVID-19 control measures on social contacts and transmission in Kenyan informal settlements
VL  - 18
ID  - 7785603
ER  - 

TY  - JOUR
AB  - This study aimed to analyze aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio in COVID-19 patients. After exclusion, 567 inpatients were included in this study and separated into two groups according to their AST/ALT ratio on admission. Death was regarded as poor prognosis in this study. Of 567 patients, 200 (35.3%) had AST/ALT ≥�?.38. Of the 200 patients, older age (median age 60 years), myalgia (64 [32%] cases), fatigue (91 [45.5%] cases), some comorbidities and outcomes were significantly different from patients with AST/ALT �?.38. They also had worse chest computed tomography (CT) findings, laboratory results and severity scores. Levels of platelet count (OR 0.995, 95% CI [0.992-0.998]) and hemoglobin (OR 0.984, 95% CI [0.972-0.995]) were independently associated with AST/ALT ≥�?.38 on admission. Furthermore, a high AST/ALT ratio on admission was an independent risk factor for poor prognosis (OR 99.9, 95% CI [2.1-4280.5]). In subsequent monitoring, both survivors and non-survivors showed decreased AST/ALT ratio during hospitalization. In conclusion, high AST/ALT ratio might be the indication of worse status and outcomes in COVID-19 patients.
AD  - Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Department of Endocrinology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, 430014, Hubei Province, China.
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Department of Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. wwb_xh@163.com.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, 100730, China. florayo@163.com.
Department of Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, 430014, Hubei Province, China. wyj_tongji@163.com.
AN  - 33020546
AU  - Qin, C.
AU  - Wei, Y.
AU  - Lyu, X.
AU  - Zhao, B.
AU  - Feng, Y.
AU  - Li, T.
AU  - Cao, H.
AU  - Yang, X.
AU  - Zhou, X.
AU  - Wang, W.
AU  - You, L.
AU  - Wang, Y.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1038/s41598-020-73575-2
DP  - NLM
ET  - 2020/10/07
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Qin, Cheng
Wei, Yingxin
Lyu, Xiaoyu
Zhao, Bangbo
Feng, Yunlu
Li, Tianhao
Cao, Hongtao
Yang, Xiaoying
Zhou, Xingtong
Wang, Weibin
You, Lei
Wang, Yujun
81773215/National Natural Science Foundation of China/
81972321/National Natural Science Foundation of China/
Journal Article
England
Sci Rep. 2020 Oct 5;10(1):16496. doi: 10.1038/s41598-020-73575-2.
PY  - 2020
SN  - 2045-2322
SP  - 16496
ST  - High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
T2  - Scientific reports
TI  - High aspartate aminotransferase to alanine aminotransferase ratio on admission as risk factor for poor prognosis in COVID-19 patients
VL  - 10
ID  - 7785022
ER  - 

TY  - JOUR
AD  - American College of Physicians, Philadelphia, Pennsylvania (A.Q., I.E.).
American College of Physicians, Philadelphia, and Villanova University, Villanova, Pennsylvania (J.Y.).
University of Massachusetts Medical School and Saint Vincent Hospital, Worcester, Massachusetts (G.M.A.).
University of Illinois College of Medicine at Urbana-Champaign, Champaign, Illinois (J.A.J.).
Penn Medicine, Philadelphia, Pennsylvania (M.A.F., M.C.M.).
Portland Veterans Affairs Medical Center and Oregon Health & Science University, Portland, Oregon (L.L.H.).
AN  - 33017175
AU  - Qaseem, A.
AU  - Yost, J.
AU  - Etxeandia-Ikobaltzeta, I.
AU  - Abraham, G. M.
AU  - Jokela, J. A.
AU  - Forciea, M. A.
AU  - Miller, M. C.
AU  - Humphrey, L. L.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.7326/m20-5831
DP  - NLM
ET  - 2020/10/06
J2  - Annals of internal medicine
LA  - eng
N1  - 1539-3704
Qaseem, Amir
Orcid: 0000-0001-6866-7985
Yost, Jennifer
Orcid: 0000-0002-3170-1956
Etxeandia-Ikobaltzeta, Itziar
Orcid: 0000-0001-6606-649x
Abraham, George M
Orcid: 0000-0003-4296-8362
Jokela, Janet A
Orcid: 0000-0003-4324-4809
Forciea, Mary Ann
Orcid: 0000-0002-1999-1145
Miller, Matthew C
Orcid: 0000-0001-7267-4897
Humphrey, Linda L
Journal Article
United States
Ann Intern Med. 2020 Oct 5. doi: 10.7326/M20-5831.
PY  - 2020
SN  - 0003-4819
ST  - Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 1)
T2  - Annals of internal medicine
TI  - Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 1)
ID  - 7785157
ER  - 

TY  - JOUR
AB  - The pandemic caused by the SARS-CoV-2 virus (COVID-19) made it necessary to evaluate in more detail the processes of neuroinflammation as an integral component of the pathogenesis of viral infection. The acute neuroinflammatory response includes the activation of resident tissue macrophages in the CNS and the subsequent release of various cytokines and chemokines, which probably activates oxidative stress, causing long-term neuronal damage. This makes urgent the search for drugs with indirect anti-inflammatory effects with proven effectiveness. From this point of view, it is worth further studying the treatment of patients with COVID-19 with dipyridamole, which, with its antiviral activity and anti-inflammatory effect, inhibiting acute inflammation and progressive fibrosis, is the drug of choice, especially for patients with early signs of elevated D-dimer concentrations and pronounced clinical symptoms of microangiopathy.
AD  - Pirogov Russian National Research Medical University, Moscow, Russia.
Filatov City Clinical Hospital No. 15, Moscow, Russia.
AN  - 33016678
AU  - Putilina, M. V.
AU  - Grishin, D. V.
C1  - 10/6/2020
DB  - PubMed
DO  - 10.17116/jnevro202012008258
DP  - NLM
ET  - 2020/10/06
IS  - 8. Vyp. 2
J2  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
KW  - SARS-CoV-2 coronavirus
cognitive impairment
cytokine storm
dipyridamole
neurodegeneration
neuroinflammation
potential therapy strategies
LA  - rus
N1  - Putilina, M V
Orcid: 0000-0002-8655-8501
Grishin, D V
Orcid: 0000-0002-3810-9971
English Abstract
Journal Article
Russia (Federation)
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8. Vyp. 2):58-64. doi: 10.17116/jnevro202012008258.
OP  - SARS-CoV-2 (COVID-19) kak prediktor neirovospaleniya i neirodegeneratsii: potentsial'nye strategii terapii.
PY  - 2020
SN  - 1997-7298 (Print)
1997-7298
SP  - 58-64
ST  - [SARS-CoV-2 (COVID-19) as a predictor of neuroinflammation and neurodegeneration: potential therapy strategies]
T2  - Zhurnal nevrologii i psikhiatrii imeni SS Korsakova
TI  - [SARS-CoV-2 (COVID-19) as a predictor of neuroinflammation and neurodegeneration: potential therapy strategies]
VL  - 120
ID  - 7785187
ER  - 

TY  - JOUR
AB  - OBJECTIVES: Comparative assessments of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) molecular assays that have been operationalized through the US Food and Drug Administration's Emergency Use Authorization process are warranted to assess real-world performance. Characteristics such as sensitivity, specificity, and false-negative rate are important to inform clinical use. METHODS: We compared five SARS-CoV-2 assays using nasopharyngeal and nasal swab specimens submitted in transport media; we enriched this cohort for positive specimens, since we were particularly interested in the sensitivity and false-negative rate. Performance of each test was compared with a composite standard. RESULTS: The sensitivities and false-negative rates of the 239 specimens that met inclusion criteria were, respectively, as follows: Centers for Disease Control and Prevention 2019 nCoV Real-Time RT-PCR Diagnostic Panel, 100% and 0%; TIB MOLBIOL/Roche z 480 Assay, 96.5% and 3.5%; Xpert Xpress SARS-CoV-2 (Cepheid), 97.6% and 2.4%; Simplexa COVID-19 Direct Kit (DiaSorin), 88.1% and 11.9%; and ID Now COVID-19 (Abbott), 83.3% and 16.7%. CONCLUSIONS: The assays that included a nucleic acid extraction followed by reverse transcription polymerase chain reaction were more sensitive than assays that lacked a full extraction. Most false negatives were seen in patients with low viral loads, as extrapolated from crossing threshold values.
AD  - Pathology and Laboratory Medicine Institute, Cleveland, OH.
Department of Infectious Diseases, Cleveland Clinic, Cleveland, OH.
AN  - 33015712
AU  - Procop, G. W.
AU  - Brock, J. E.
AU  - Reineks, E. Z.
AU  - Shrestha, N. K.
AU  - Demkowicz, R.
AU  - Cook, E.
AU  - Ababneh, E.
AU  - Harrington, S. M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1093/ajcp/aqaa181
DP  - NLM
ET  - 2020/10/06
J2  - American journal of clinical pathology
KW  - Covid-19
Coronavirus
Nucleic acid amplification tests
SARS-CoV-2
LA  - eng
N1  - 1943-7722
Procop, Gary W
Brock, Jay E
Reineks, Edmunds Z
Shrestha, Nabin K
Demkowicz, Ryan
Cook, Eleanor
Ababneh, Emad
Harrington, Susan M
Journal Article
England
Am J Clin Pathol. 2020 Oct 5:aqaa181. doi: 10.1093/ajcp/aqaa181.
PY  - 2020
SN  - 0002-9173
ST  - A Comparison of Five SARS-CoV-2 Molecular Assays With Clinical Correlations
T2  - American journal of clinical pathology
TI  - A Comparison of Five SARS-CoV-2 Molecular Assays With Clinical Correlations
ID  - 7785257
ER  - 

TY  - JOUR
AD  - Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037, USA. Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA 24061, USA. Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA. Division of Occupational & Environmental Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. School of Medicine, University of California, San Francisco, CA 94143, USA. Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA. Institute for Applied Environmental Health, University of Maryland, College Park, MD 20742, USA.
AN  - 33020250
AU  - Prather, K. A.
AU  - Marr, L. C.
AU  - Schooley, R. T.
AU  - McDiarmid, M. A.
AU  - Wilson, M. E.
AU  - Milton, D. K.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1126/science.abf0521
DP  - NLM
ET  - 2020/10/07
J2  - Science (New York, N.Y.)
LA  - eng
N1  - 1095-9203
Prather, Kimberly A
Marr, Linsey C
Schooley, Robert T
McDiarmid, Melissa A
Wilson, Mary E
Milton, Donald K
Letter
United States
Science. 2020 Oct 5:eabf0521. doi: 10.1126/science.abf0521.
PY  - 2020
SN  - 0036-8075
ST  - Airborne transmission of SARS-CoV-2
T2  - Science (New York, NY)
TI  - Airborne transmission of SARS-CoV-2
ID  - 7785042
ER  - 

TY  - JOUR
AB  - Background: Favipiravir is a promising drug for COVID-19, but evidence from a robust clinical trial is limited Objective: To describe the demographics, clinical characteristics, and various antiviral treatment regimens (with and without favipiravir) of patients with severe and nonsevere COVID-19 Method: We conducted a retrospective observational study in all COVID-19 patients admitted at Bamrasnaradura Infectious Diseases Institute (BIDI) from January 8 to March 30, 2020 We compared the demographics, clinical characteristics, and various antiviral treatment regimens of 12 severe and 29 nonsevere COVID-19 patients in Thailand Results: Adjunctive favipiravir was given to only severe cases The median length of hospitalization of patients either receiving favipiravir or not receiving favipiravir was not significantly different (P = 0 8549), but those who received adjunctive favipiravir became reverse transcriptase-polymerase chain reaction negative 2 days sooner than the other group (median: 6 days vs 8 days;P = 0 1125) Conclusion: The findings suggested that adjunctive favipiravir might not be effective for patients with severe COVID-19, but further studies with larger sample sizes are needed
AU  - Prasithsirikul, Wisit
AU  - Pongpirul, Krit
AU  - Sakornsakolpat, Phuwanat
AU  - Burana, Chuti
AU  - Phutrakool, Phanupong
AU  - Pongpirul, Wannarat A.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Adjunctive favipiravir for severe COVID-19: a retrospective observational study of the first 41 patients in Thailand
T2  - Asian Biomedicine
TI  - Adjunctive favipiravir for severe COVID-19: a retrospective observational study of the first 41 patients in Thailand
UR  - https://doi.org/10.1515/abm-2020-0016
ID  - 7788360
ER  - 

TY  - JOUR
AB  - This paper studies the cybersecurity issues that have occurred during the coronavirus (COVID-19) pandemic During the pandemic, cyber criminals and Advanced Persistent Threat (APT) groups have taken advantage of targeting vulnerable people and systems This paper emphasizes that there is a correlation between the pandemic and the increase in cyber-attacks targeting sectors that are vulnerable In addition, the growth in anxiety and fear due to the pandemic is increasing the success rate of cyber-attacks We also highlight that healthcare organizations are one of the main victims of cyber-attacks during the pandemic The pandemic has also raised the issue of cybersecurity in relation to the new normal of expecting staff to work from home (WFH), the possibility of state-sponsored attacks, and increases in phishing and ransomware We have also provided various practical approaches to reduce the risks of cyber-attacks while WFH including mitigation of security risks related to healthcare It is crucial that healthcare organizations improve protecting their important data and assets by implementing a comprehensive approach to cybersecurity This article is protected by copyright All rights reserved
AU  - Pranggono, Bernardi
AU  - Arabo, Abdullahi
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 Pandemic Cybersecurity Issues
T2  - Internet Technology Letters
TI  - COVID-19 Pandemic Cybersecurity Issues
UR  - https://doi.org/10.1002/itl2.247
ID  - 7788143
ER  - 

TY  - JOUR
AB  - Throughout the COVID-19 pandemic, the main risk factors associated with the progression to severe disease or death have been typically advanced age, diabetes mellitus, obesity, high blood pressure, heart disease, and chronic pneumopathy. Because of their immunosuppression status, persons with HIV were also expected to have a higher susceptibility to infection or a poor clinical evolution. So far, this has not been confirmed to happen, giving way to hypotheses about the role of immunosuppression or the use of antiretrovirals, which could explain this paradox. In this article we present the existing data on the epidemiology and characteristics of HIV-COVID-19 co-infection, discuss the available evidence on the possible factors involved in the evolution of individuals affected by both viruses, analyze other determinants that may negatively affect persons with HIV during the pandemic, and present recommendations for the prevention and care of COVID-19 infection in the context of HIV.
AD  - Grupo VIHCOL, Cali, Colombia.
Corporaci�Qn para Investigaciones Biol�Qgicas, Unidad de Investigaci�Qn Cl�Tnica. Medellin, Colombia.
Red de VIH/SIDA del Valle del Cauca, REVIVA, Cali, Colombia.
Universidad del Valle, Facultad de Salud, Departamento de Medicina Interna, Cali, Colombia.
Hospital Universitario del Valle Evaristo Garc�Ta, Cali, Colombia.
AN  - 33012892
AU  - Posada-Vergara, M. P.
AU  - Alzate-Ángel, J. C.
AU  - Mart�Tnez-Buitrago, E.
C1  - 10/6/2020
C2  - PMC7518728
DA  - Jun 30
DB  - PubMed
DO  - 10.25100/cm.v51i2.4327
DP  - NLM
ET  - 2020/10/06
IS  - 2
J2  - Colombia medica (Cali, Colombia)
KW  - Covid-19
Hiv
SARS virus
coinfection
LA  - eng
N1  - 1657-9534
Posada-Vergara, Mar�Ta Paulina
Orcid: 0000-0002-1516-1662
Alzate-Ángel, Juan Carlos
Orcid: 0000-0003-0319-0623
Mart�Tnez-Buitrago, Ernesto
Orcid: 0000-0002-0959-8593
Journal Article
Review
Colomb Med (Cali). 2020 Jun 30;51(2):e4327. doi: 10.25100/cm.v51i2.4327.
PY  - 2020
SN  - 0120-8322 (Print)
0120-8322
SP  - e4327
ST  - COVID-19 and VIH
T2  - Colombia medica (Cali, Colombia)
TI  - COVID-19 and VIH
VL  - 51
ID  - 7785535
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic is a unique opportunity to examine the relationships between hospitalists, neurosurgeons, and patients. Each individual must weigh the risk of further virus spread during a pandemic, while maintaining personal and professional obligations. Here we reflect on the experience of both neurosurgeon and hospitalist. We identify a need for interdisciplinary reflection and collaboration so that a potential second wave or future pandemic might be better mitigated.
AD  - Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address: jporras1@jhmi.edu.
Division of Hospital Medicine, Yale New Haven Health Bridgeport Hospital, New Haven, CT, USA.
Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
AN  - 33011359
AU  - Porras, J. L.
AU  - Mallipudi, R.
AU  - Sciubba, D. M.
C1  - 10/6/2020
C2  - PMC7529667
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.wneu.2020.09.159
DP  - NLM
ET  - 2020/10/05
J2  - World neurosurgery
KW  - Covid-19
consult
hospitalist
LA  - eng
N1  - 1878-8769
Porras, Jose Luis
Mallipudi, Rajiv
Sciubba, Daniel Michael
Journal Article
World Neurosurg. 2020 Oct 1:S1878-8750(20)32178-1. doi: 10.1016/j.wneu.2020.09.159.
PY  - 2020
SN  - 1878-8750 (Print)
1878-8750
ST  - "How the Social Isolation of the COVID-19 Pandemic Creates Opportunity for Interdisciplinary Collaboration"
T2  - World neurosurgery
TI  - "How the Social Isolation of the COVID-19 Pandemic Creates Opportunity for Interdisciplinary Collaboration"
ID  - 7785675
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic is nowhere near over. Some things, however, seem relatively clear. So far, the agendas of the world's most powerful actors seem unchanged—or, indeed, accelerated. Partly as a result, disease mortality and economic losses have fallen largely on poorer people, though deaths so far have been concentrated among poorer people in rich countries. Consequently, the pandemic's implications look very different at the local, subnational, and international levels—although at all levels, they thus far reflect accelerations of preexisting trends more than new departures. Many developments reflect remarkable gains in human capacity to cope with disasters—a point highlighted by comparisons to the 1919 flu and other historical events pandemics made by the authors in this forum. Those gains are particularly evident in Asia, though they look more precarious in South Asia and Southeast Asia than in East Asia; this has contributed to a marked shift in rhetoric about global “sickness�?and health and seems consistent with prophecies of a coming “Asian century.�?However, COVID-19 may not be a singular event like 1919 but may portend a wave of environmental emergencies; in that scenario, no world region has exhibited as much resilience as it would need.
AD  - Kenneth Pomeranz ( kpomeranz1@uchicago.edu ) is University Professor of Modern Chinese History, East Asian Languages and Civilization, and in the College at the University of Chicago ; Kenneth Pomeranz ( kpomeranz1@uchicago.edu ) is University Professor of Modern Chinese History, East Asian Languages and Civilization, and in the College at the University of Chicago
AN  - 2448360910
AU  - Pomeranz, Kenneth
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1017/S0021911820002338
DP  - ProQuest Central
IS  - 3
KW  - Literature
COVID-19
East Asia
South Asia
migrants
inequality
racism
telecommunications
environmental crisis
global politics
poverty
Vaccines
Historical events
Success
Power
Politics
Pandemics
Influenza
Deaths
Rhetoric
Insecure
Prophecies
Coronaviruses
Resilience
Disasters
Hong Kong
United States--US
Asia
China
Japan
India
LA  - English
N1  - Copyright - Copyright © The Association for Asian Studies, Inc., 2020
SubjectsTermNotLitGenreText - United States--US; India; China; Hong Kong; Asia; Japan
PY  - 2020
SN  - 00219118
SP  - 621-631
ST  - Afterword: Lives Interrupted, Trends Continued?
T2  - Journal of Asian Studies
TI  - Afterword: Lives Interrupted, Trends Continued?
UR  - https://www.proquest.com/docview/2448360910?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Afterword%3A+Lives+Interrupted%2C+Trends+Continued%3F&title=The+Journal+of+Asian+Studies&issn=00219118&date=2020-08-01&volume=79&issue=3&spage=621&au=Pomeranz%2C+Kenneth&isbn=&jtitle=The+Journal+of+Asian+Studies&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1017%2FS0021911820002338
VL  - 79
ID  - 7784918
ER  - 

TY  - JOUR
AB  - In the midst of the severe acute respiratory syndrome coronavirus 2 pandemic and its attendant morbidity and mortality, safe and efficacious vaccines are needed that induce protective and long-lived immune responses. More than 120 vaccine candidates worldwide are in various preclinical and phase 1 to 3 clinical trials that include inactivated, live-attenuated, viral-vectored replicating and nonreplicating, protein- and peptide-based, and nucleic acid approaches. Vaccines will be necessary both for individual protection and for the safe development of population-level herd immunity. Public-private partnership collaborative efforts, such as the Accelerating COVID-19 Therapeutic Interventions and Vaccines mechanism, are key to rapidly identifying safe and effective vaccine candidates as quickly and efficiently as possible. In this article, we review the major vaccine approaches being taken and issues that must be resolved in the quest for vaccines to prevent coronavirus disease 2019. For this study, we scanned the PubMed database from 1963 to 2020 for all publications using the following search terms in various combinations: SARS, MERS, COVID-19, SARS-CoV-2, vaccine, clinical trial, coronavirus, pandemic, and vaccine development. We also did a Web search for these same terms. In addition, we examined the World Health Organization, Centers for Disease Control and Prevention, and other public health authority websites. We excluded abstracts and all articles that were not written in English. Copyright © 2020 Mayo Foundation for Medical Education and Research
AD  - (Poland, Ovsyannikova, Crooke, Kennedy) Vaccine Research Group, Mayo Clinic, Rochester, MN
G.A. Poland, Vaccine Research Group, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States. E-mail: poland.gregory@mayo.edu
AN  - 2007954614
AU  - Poland, G. A.
AU  - Ovsyannikova, I. G.
AU  - Crooke, S. N.
AU  - Kennedy, R. B.
C1  - 10/6/2020
DA  - October
DB  - Embase
DO  - http://dx.doi.org/10.1016/j.mayocp.2020.07.021
DP  - Ovid Technologies
IS  - 10
KW  - clinical trial
controlled study
coronavirus disease 2019
disease control
drug therapy
herd immunity
human
Medline
pandemic
phase 1 clinical trial (topic)
preclinical study
prevention
public health
public-private partnership
review
severe acute respiratory syndrome
systematic review
World Health Organization
endogenous compound
nucleic acid
SARS CoV 2 vaccine
LA  - English
M3  - Review
PY  - 2020
SN  - 0025-6196
1942-5546
SP  - 2172-2188
ST  - SARS-CoV-2 Vaccine Development: Current Status
T2  - Mayo Clinic Proceedings
TI  - SARS-CoV-2 Vaccine Development: Current Status
UR  - http://www.journals.elsevier.com/mayo-clinic-proceedings
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007954614
VL  - 95
ID  - 7782907
ER  - 

TY  - JOUR
AD  - Servicio de Endocrinolog�Ta y Nutrici�Qn, Hospital Universitario de La Princesa, Instituto de Investigaci�Qn Princesa, Universidad Aut�Qnoma de Madrid, Madrid, España.
Servicio de Endocrinolog�Ta y Nutrici�Qn, Hospital Universitario de La Princesa, Instituto de Investigaci�Qn Princesa, Universidad Aut�Qnoma de Madrid, Madrid, España. Electronic address: monica.hup@gmail.com.
AN  - 33012671
AU  - Pla, B.
AU  - Silva, M.
AU  - Arranz, A.
AU  - Marazuela, M.
C1  - 10/6/2020
DA  - Sep 2
DB  - PubMed
DO  - 10.1016/j.endinu.2020.06.002
DP  - NLM
ET  - 2020/10/06
J2  - Endocrinologia, diabetes y nutricion
LA  - eng
spa
N1  - 2530-0172
Pla, Begoña
Silva, Maria
Arranz, Alfonso
Marazuela, Monica
Letter
Spain
Endocrinol Diabetes Nutr. 2020 Sep 2:S2530-0164(20)30163-4. doi: 10.1016/j.endinu.2020.06.002.
OP  - Hipocalcemia severa y resistente al tratamiento en paciente con neumon�Ta bilateral COVID-19.
PY  - 2020
SN  - 2530-0164
ST  - Severe and treatment-resistant hypocalcemia in patient with bilateral COVID-19 pneumonia
T2  - Endocrinologia, diabetes y nutricion
TI  - Severe and treatment-resistant hypocalcemia in patient with bilateral COVID-19 pneumonia
ID  - 7785562
ER  - 

TY  - JOUR
AB  - AIM: In many countries nursing home populations have accounted for half of all deaths during the first wave of COVID-19. FINDINGS: Infection and risk of death are not the only risks related to COVID-19. The lockdown causes risks of cognitive decline, depression, anxiety, frailty and disabilities. MESSAGE: The risks of prolonged isolation should be weighted against the COVID-19 risks.
AD  - Unit of Primary Health Care, Department of General Practice and Primary Health Care, Helsinki University Hospital, University of Helsinki, PO Bo x20, 00014, Helsinki, Finland. kaisu.pitkala@helsinki.fi.
AN  - 33011911
AU  - Pitkälä, K. H.
C1  - 10/6/2020
C2  - PMC7532929
DA  - Oct 3
DB  - PubMed
DO  - 10.1007/s41999-020-00411-1
DP  - NLM
ET  - 2020/10/05
J2  - European geriatric medicine
LA  - eng
N1  - 1878-7657
Pitkälä, Kaisu H
Editorial
Eur Geriatr Med. 2020 Oct 3:1-3. doi: 10.1007/s41999-020-00411-1.
PY  - 2020
SN  - 1878-7649 (Print)
1878-7649
SP  - 1-3
ST  - COVID-19 has hit nursing homes hard
T2  - European geriatric medicine
TI  - COVID-19 has hit nursing homes hard
ID  - 7785645
ER  - 

TY  - JOUR
AD  - Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy. Electronic address: piccolo.vincenzo@gmail.com.
Unità Operativa Dermatologia Lucca-Azienda Unità Sanitaria Locale, Toscana Nordovest, Italy; Department of Health Science, University of Florence, Italy.
Dermatology Unit, University of Campania Luigi Vanvitelli, Naples, Italy.
Unità Operativa Dermatologia Lucca-Azienda Unità Sanitaria Locale, Toscana Nordovest, Italy.
Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Italy.
AN  - 33010953
AU  - Piccolo, V.
AU  - Bassi, A.
AU  - Argenziano, G.
AU  - Mazzatenta, C.
AU  - Guglielmo, A.
AU  - Patrizi, A.
AU  - Neri, I.
C1  - 10/6/2020
C2  - PMC7526605
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.jaad.2020.07.058
DP  - NLM
ET  - 2020/10/05
J2  - Journal of the American Academy of Dermatology
LA  - eng
N1  - 1097-6787
Piccolo, Vincenzo
Bassi, Andrea
Argenziano, Giuseppe
Mazzatenta, Carlo
Guglielmo, Alba
Patrizi, Annalisa
Neri, Iria
Journal Article
J Am Acad Dermatol. 2020 Sep 30:S0190-9622(20)32257-X. doi: 10.1016/j.jaad.2020.07.058.
PY  - 2020
SN  - 0190-9622 (Print)
0190-9622
ST  - Dermoscopy of chilblain-like lesions during the COVID-19 outbreak: A multicenter study on 10 patients
T2  - Journal of American Academy of Dermatology
TI  - Dermoscopy of chilblain-like lesions during the COVID-19 outbreak: A multicenter study on 10 patients
ID  - 7785711
ER  - 

TY  - JOUR
AB  - The Italian Government has decreed a series of progressive restrictions to delay the COVID-19 pandemic diffusion in Italy since March 10, 2020, including limitation in individual mobility and the closure of social, cultural, economic and industrial activities. Here we show the lockdown effect in Northern Italy, the COVID-19 most affected area, as revealed by noise variation at seismic stations. The reaction to lockdown was slow and not homogeneous with spots of negligible noise reduction, especially in the first week. A fresh interpretation of seismic noise variations in terms of socio-economic indicators sheds new light on the lockdown efficacy pointing to the causes of such delay: the noise reduction is significant where non strategic activities prevails, while it is small or negligible where dense population and strategic activities are present. These results are crucial for the a posteriori interpretation of the pandemic diffusion and the efficacy of differently targeted political actions.
AD  - Istituto Nazionale di Geofisica e Vulcanologia, Sezione Di Pisa, Via Cesare Battisti 53, 56125, Pisa, Italy. davide.piccinini@ingv.it.
Istituto Nazionale di Geofisica e Vulcanologia, Sezione Di Pisa, Via Cesare Battisti 53, 56125, Pisa, Italy.
Istituto Nazionale di Geofisica e Vulcanologia, Sezione Di Bologna, Via Donato Creti 12, 40128, Bologna, Italy.
Department of Economics and Management, University of Ferrara, Via Voltapaletto 11, 44121, Ferrara, Italy.
Istituto Nazionale di Geofisica e Vulcanologia, Osservatorio Nazionale Terremoti, Via di Vigna Murata 605, 00143, Rome, Italy.
AN  - 33020508
AU  - Piccinini, D.
AU  - Giunchi, C.
AU  - Olivieri, M.
AU  - Frattini, F.
AU  - Di Giovanni, M.
AU  - Prodi, G.
AU  - Chiarabba, C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1038/s41598-020-73102-3
DP  - NLM
ET  - 2020/10/07
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Piccinini, Davide
Giunchi, Carlo
Olivieri, Marco
Frattini, Federico
Di Giovanni, Matteo
Prodi, Giorgio
Chiarabba, Claudio
Journal Article
England
Sci Rep. 2020 Oct 5;10(1):16487. doi: 10.1038/s41598-020-73102-3.
PY  - 2020
SN  - 2045-2322
SP  - 16487
ST  - COVID-19 lockdown and its latency in Northern Italy: seismic evidence and socio-economic interpretation
T2  - Scientific reports
TI  - COVID-19 lockdown and its latency in Northern Italy: seismic evidence and socio-economic interpretation
VL  - 10
ID  - 7785023
ER  - 

TY  - JOUR
AB  - Since the appearance of the novel coronavirus (severe acute respiratory syndrome-coronavirus-2) and related coronavirus disease 2019 (COVID-19) in China in December 2019, a very high number of small and large patient series have been published in literature from around the world. Even though the classical presentation of COVID-19 is one with respiratory symptoms with or without pneumonia that can be self-limiting or evolve into severe respiratory distress syndrome with multiple organ failure, and secondary bacterial sepsis, a large body of evidence suggests a plethora of other types of clinical presentation. In this exhaustive review, we reviewed all of the published literature on COVID-19 to identify different types of clinical presentations affecting various organ systems, to provide an in-depth analysis that may prove useful for clinicians and health-workers on the frontline, battling the severe pandemic. Copyright © The Author(s) 2020.
AD  - (Philips, Mohan) The Liver Unit and Monarch, Cochin Gastroenterology Group, Ernakulam Medical Center, Cochin, Kerala 682025, India (Ahamed, Kumbar, Augustine) Gastroenterology and Advanced GI Endoscopy, Cochin Gastroenterology Group, Ernakulam Medical Center, Cochin, Kerala 682025, India (Rajesh, George) Division of Hepatobiliary Interventional Radiology, Cochin Gastroenterology Group, Ernakulam Medical Center, Cochin, Kerala 682025, India (Mohanan) Anesthesia and Critical Care, Cochin Gastroenterology Group, Ernakulam Medical Center, Cochin, Kerala 682025, India
C.A. Philips, Consultant Physician-Scientist, The Liver Unit and Monarch Liver Lab, Cochin Gastroenterology Group, Ernakulam Medical Center, NH Bypass, Palarivattom, Cochin, Kerala 682025, India. E-mail: abbyphilips@gmail.com
AN  - 632998339
AU  - Philips, C. A.
AU  - Mohan, N.
AU  - Ahamed, R.
AU  - Kumbar, S.
AU  - Rajesh, S.
AU  - George, T.
AU  - Mohanan, M.
AU  - Augustine, P.
C1  - 10/6/2020
DA  - 26 Sep
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i18.3956
DP  - Ovid Technologies
IS  - 18
KW  - Adult respiratory distress syndrome
Centers for disease control
covid-19
SARS-CoV-2
Sepsis
World health organization
coronavirus disease 2019
disease control
human
organ systems
pandemic
review
systematic review
LA  - English
M3  - Review
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 3956-3970
ST  - One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease
T2  - World Journal of Clinical Cases
TI  - One disease, many faces-typical and atypical presentations of SARS-CoV-2 infection-related COVID-19 disease
UR  - https://f6publishing.blob.core.windows.net/2ab0884c-0618-4586-aaf1-41004e6ad656/WJCC-8-3956.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998339
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i18.3956&issn=2307-8960&isbn=&volume=8&issue=18&spage=3956&pages=3956-3970&date=2020&title=World+Journal+of+Clinical+Cases&atitle=One+disease%2C+many+faces-typical+and+atypical+presentations+of+SARS-CoV-2+infection-related+COVID-19+disease&aulast=Philips&pid=%3Cauthor%3EPhilips+C.A.%2CMohan+N.%2CAhamed+R.%2CKumbar+S.%2CRajesh+S.%2CGeorge+T.%2CMohanan+M.%2CAugustine+P.%3C%2Fauthor%3E&%3CAN%3E632998339%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 8
ID  - 7782816
ER  - 

TY  - JOUR
AB  - To date, COVID-19 has claimed more than 100 000 American lives Early inquiry suggests preexisting conditions are key risk factors contributing to COVID-19 mortality and air pollution exposure could exacerbate this relationship Building on prior research linking deaths from respiratory viruses to air pollution exposures, we investigate how 2014 National Air Toxics Assessment hazardous air pollutants (HAPs) respiratory hazard quotient and respiratory hazard index are related to COVID-19 mortality Our focus on HAPs builds upon the knowledge base linking poor air quality to COVID-19 mortality, since most (if not all) earlier studies only include criteria pollutants Herein, we examine the relationship between HAP exposure and US-based COVID-19 mortality, while controlling for socioeconomic status, population health indicators, and exposure to PM2 5 and ozone We fit county-level negative binomial mixed models, predicting COVID-19 mortality as a function of HAP respiratory toxicity levels and relevant covariates We include models for combined exposure to HAPs, as well as for specific pollutants We find that an increase in the respiratory hazard index is associated with a 9% increase in COVID-19 mortality Although differing in magnitude, this association holds for individual HAPs acetaldehyde, and diesel PM These findings help us to understand variation in US-based COVID-19 mortality rates, reinforce existing research linking air pollution to mortality, and emphasize the importance of regulatory efforts to limit air pollution exposure risk
AU  - Petroni, Michael
AU  - Hill, Dustin
AU  - Younes, Lylla
AU  - Barkman, Liesl
AU  - Howard, Sarah
AU  - Howell, I. Brielle
AU  - Mirowsky, Jaime
AU  - Collins, Mary B.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Hazardous air pollutant exposure as a contributing factor to COVID-19 mortality in the United States
T2  - Environmental Research Letters
TI  - Hazardous air pollutant exposure as a contributing factor to COVID-19 mortality in the United States
UR  - https://doi.org/10.1088/1748-9326/abaf86
ID  - 7788224
ER  - 

TY  - JOUR
AB  - Four recent reports from the National Academies of Sciences, Engineering, and Medicine framed around the issues of poverty; mental, emotional, and behavioral health; adolescence; and young family health and education build on extensive recent evidence of what can be done to improve the health and well-being of children, youth, and families. We describe the process of generating the reports, briefly summarize each report's content, and identify crosscutting themes and recommendations. We also note how the coronavirus disease 2019 (COVID-19) pandemic highlights major disparities and systemic problems addressed in the reports and heightens the relevance of their policy recommendations. The reports issue a unified, urgent call for measures with the potential to change the trajectory and outcomes for children and youth. Among these are basic income supports, other family supports, universal health care structured to meet family needs, and a broad national policy that prioritizes children and youth.
AD  - James M. Perrin (jperrin@mgh.harvard.edu) is a professor of pediatrics at Harvard Medical School and holds the John C. Robinson Distinguished Chair in Pediatrics at MassGeneral Hospital for Children, both in Boston, Massachusetts.
Greg Duncan is a professor of education at the University of California Irvine, in Irvine, California.
Angela Diaz is a professor of pediatrics, environmental medicine, and public health at the Icahn School of Medicine at Mt. Sinai, in New York, New York.
Kelly Kelleher is a professor of pediatrics and psychiatry at Nationwide Children's Hospital and the Ohio State University School of Medicine, in Columbus, Ohio.
AN  - 33017241
AU  - Perrin, J. M.
AU  - Duncan, G.
AU  - Diaz, A.
AU  - Kelleher, K.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1377/hlthaff.2020.00709
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Health affairs (Project Hope)
LA  - eng
N1  - 1544-5208
Perrin, James M
Duncan, Greg
Diaz, Angela
Kelleher, Kelly
Journal Article
United States
Health Aff (Millwood). 2020 Oct;39(10):1677-1683. doi: 10.1377/hlthaff.2020.00709.
PY  - 2020
SN  - 0278-2715
SP  - 1677-1683
ST  - Principles And Policies To Strengthen Child And Adolescent Health And Well-Being
T2  - Health affairs (Project Hope)
TI  - Principles And Policies To Strengthen Child And Adolescent Health And Well-Being
VL  - 39
ID  - 7785147
ER  - 

TY  - JOUR
AB  - This paper discusses an optimization model for handling the impact of the COVID-19 pandemic based on food supply network through regional food hubs (RFHs) under uncertainty. To this end, uncertainty is assumed in the demand and production data. During the Pandemic COVID-19 period, uncertainty has increased and the food supply chain system has changed. Thus, a new configuration of the food supply network requires analysis. In this paper, the concept of RFH is introduced to connect producers in rural areas and customers in urban areas. This paper determines the location and capacity of RFHs, the food supply network, the sum of maximum food supplies, and minimum logistics cost. This is done via a Multi-Objective Many-to-Many Location-Routing Problem model. Furthermore, since the conditions of the COVID-19 pandemic is uncertain, robust optimization is employed to handle uncertainties. During the current pandemic, red zones are defined to indicate the severity of the pandemic in a region. In this paper, the numerical experiment is considered for three scenarios: when a region is in large-scale social distancing, partial social distancing, or normal conditions. This social distancing situation is based on the defined red zones. The optimal food supply network is obtained for the three scenarios and the best scenario among the three is identified.
AD  - Department of Agro Socio-Economics, Faculty of Agriculture, Universitas Padjadjaran Jl.Raya Bandung-Sumedang KM 21, Jatinangor, Sumedang, West Java Province 45363, Indonesia.
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Indonesia.
Agricultural Logistics and Supply Chain System (AGRILOGICS), Universitas Padjadjaran, Indonesia.
AN  - 33020743
AU  - Perdana, T.
AU  - Chaerani, D.
AU  - Achmad, A. L. H.
AU  - Hermiatin, F. R.
C1  - 10/6/2020
C2  - PMC7526684
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.heliyon.2020.e05128
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Heliyon
KW  - Agricultural policy
COVID-19 pandemic
Food security
Logistics
Many-to-many location-routing problem
Multi-objective
Regional food hubs
Robust optimization
Sustainable business
Systems engineering
Systems theory
LA  - eng
N1  - Perdana, Tomy
Chaerani, Diah
Achmad, Audi Luqmanul Hakim
Hermiatin, Fernianda Rahayu
Journal Article
England
Heliyon. 2020 Sep 30;6(10):e05128. doi: 10.1016/j.heliyon.2020.e05128. eCollection 2020 Oct.
PY  - 2020
SN  - 2405-8440 (Print)
2405-8440
SP  - e05128
ST  - Scenarios for handling the impact of COVID-19 based on food supply network through regional food hubs under uncertainty
T2  - Heliyon
TI  - Scenarios for handling the impact of COVID-19 based on food supply network through regional food hubs under uncertainty
VL  - 6
ID  - 7784983
ER  - 

TY  - JOUR
AB  - Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.
AD  - Texas A&M University, College Station, Texas 77843, USA.
University of Science and Technology of China, Hefei 230026, China.
University of Maryland, Baltimore County, Baltimore, Maryland 21250, USA.
Zhejiang University, Hangzhou 310027, China.
AN  - 33012808
AU  - Peng, T.
AU  - Liu, X.
AU  - Adams, L. G.
AU  - Agarwal, G.
AU  - Akey, B.
AU  - Cirillo, J.
AU  - Deckert, V.
AU  - Delfan, S.
AU  - Fry, E.
AU  - Han, Z.
AU  - Hemmer, P.
AU  - Kattawar, G.
AU  - Kim, M.
AU  - Lee, M. C.
AU  - Lu, C.
AU  - Mogford, J.
AU  - Nessler, R.
AU  - Neuman, B.
AU  - Nie, X.
AU  - Pan, J.
AU  - Pryor, J.
AU  - Rajil, N.
AU  - Shih, Y.
AU  - Sokolov, A.
AU  - Svidzinsky, A.
AU  - Wang, D.
AU  - Yi, Z.
AU  - Zheltikov, A.
AU  - Scully, M.
C1  - 10/6/2020
C2  - PMC7518548
DA  - Sep 21
DB  - PubMed
DO  - 10.1063/5.0021842
DP  - NLM
ET  - 2020/10/06
IS  - 12
J2  - Applied physics letters
LA  - eng
N1  - 1077-3118
Peng, Tao
Orcid: 0000-0002-5296-240x
Liu, Xiangpei
Adams, L Garry
Agarwal, Girish
Akey, Bruce
Cirillo, Jeffrey
Deckert, Volker
Delfan, Sahar
Fry, Edward
Han, Zehua
Hemmer, Philip
Kattawar, George
Kim, Moochan
Lee, Ming-Che
Lu, Chaoyang
Mogford, Jon
Nessler, Reed
Orcid: 0000-0001-5692-6150
Neuman, Ben
Orcid: 0000-0003-1240-8954
Nie, Xiaoyu
Orcid: 0000-0003-3408-1630
Pan, Jianwei
Pryor, Jane
Rajil, Navid
Shih, Yanhua
Sokolov, Alexei
Orcid: 0000-0002-6879-7840
Svidzinsky, Anatoly
Wang, Dawei
Yi, Zhenhuan
Orcid: 0000-0003-4827-1013
Zheltikov, Aleksei
Scully, Marlan
Orcid: 0000-0001-6397-4927
Journal Article
Appl Phys Lett. 2020 Sep 21;117(12):120601. doi: 10.1063/5.0021842.
PY  - 2020
SN  - 0003-6951 (Print)
0003-6951
SP  - 120601
ST  - Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2
T2  - Applied physics letters
TI  - Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2
VL  - 117
ID  - 7785555
ER  - 

TY  - JOUR
AB  - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection has been a global challenge. The complicated forms of the Coronavirus Disease 2019 (COVID-19) can evolve to multiple-organ failure, including several coagulopathies related to a sudden worsening of respiratory status. This article aimed to review studies about hematological and hemostatic laboratory disorders directly related to COVID-19 and to discuss how SARS-CoV-2 causes these abnormalities. The coagulation cascade model is associated with both COVID-19 and pulmonary involvement. Laboratory changes are relevant to evaluate the coagulation state - D-dimer, prothrombin time (PT), Activated Partial Thromboplastin Time (APTT), platelet count and fibrinogen. Pregnants and patients in Extracorporeal Membrane Oxygenation (ECMO) need special attention. Prophylactic interventions for COVID-19 coagulopathy should consider patients at risk for thrombotic events and potential contraindications. The mechanisms exerted by SARS-CoV-2 that impairs hemostatic balance include endothelial injury, inflammation, activation of the immune and complement systems. For diagnosis of coagulopathy, mainly Ddimer, but also PT, APTT and FDP, should be evaluated in COVID-19 patients. Intervention possibilities vary between lowmolecular-weight heparin (LMWH) and Unfractionated Heparin (UFH). Up to now, there is sufficient evidence that acutelyill patients with risk factors for coagulopathies will benefit from thrombophylaxis during hospitalization and post-discharge, but not all patients.
AD  - Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais, UFMG, Belo Horizonte, Minas Gerais. Brazil.
AN  - 33019920
AU  - Pena, A. L. B.
AU  - Oliveira, R. A.
AU  - Severo, R. G.
AU  - Simões, E. Silva A. C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.2174/0929867327666201005112231
DP  - NLM
ET  - 2020/10/07
J2  - Current medicinal chemistry
KW  - Acute respiratory distress syndrome
Covid-19
Coagulation
Coagulopathy
SARS-CoV-2.
angiotensin-converting enzyme 2
LA  - eng
N1  - 1875-533x
Pena, Ana Lu�Tsa Batista
Oliveira, Rafael Arantes
Severo, Renata Gomes
Simões E Silva, Ana Cristina
Journal Article
United Arab Emirates
Curr Med Chem. 2020 Oct 5. doi: 10.2174/0929867327666201005112231.
PY  - 2020
SN  - 0929-8673
ST  - COVID-19 related coagulopathy: what is known up to now
T2  - Current medicinal chemistry
TI  - COVID-19 related coagulopathy: what is known up to now
ID  - 7785072
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The impact of atrial arrhythmias on COVID-19-associated outcomes are unclear. We sought to identify prevalence, risk factors and outcomes associated with atrial arrhythmias among patients hospitalized with COVID-19. METHODS: An observational cohort study of 1053 patients with SARS-CoV2 infection admitted to a quaternary care hospital and a community hospital was conducted. Data from electrocardiographic and telemetry were collected to identify atrial fibrillation (AF) or atrial flutter/tachycardia (AFL). The association between atrial arrhythmias and 30-day mortality was assessed with multivariable analysis. RESULTS: Mean age of patients was 62 �u 17 years and 62% were men. Atrial arrhythmias were identified in 166 (15.8%) patients, with AF in 154 (14.6%) patients and AFL in 40 (3.8%) patients. Newly detected atrial arrhythmias occurred in 101 (9.6%) patients. Age, male sex, prior AF, renal disease, and hypoxia on presentation were independently associated with AF/AFL occurrence. Compared to patients without AF/AFL, patients with AF/AFL had significantly higher levels of troponin, B-type natriuretic peptide, C-reactive protein, ferritin and D-dimer. Mortality was significantly higher among patients with AF/AFL (39.2%) compared to patients without (13.4%; P0.001). After adjustment for age and co-morbidities, AF/AFL (adjusted OR 1.93; P = 0.007) and newly detected AF/AFL (adjusted OR 2.87; P 0.001) were independently associated with 30-day mortality. CONCLUSIONS: Atrial arrhythmias are common among patients hospitalized with COVID-19. The presence of AF/AFL tracked with markers of inflammation and cardiac injury. Atrial arrhythmias were independently associated with increased mortality. This article is protected by copyright. All rights reserved.
AD  - Department of Medicine, Division of Cardiology, Weill Cornell Medicine - New York Presbyterian Hospital, New York, NY, United States.
Department of Medicine, Division of General Internal Medicine, Weill Cornell Medicine - New York Presbyterian Hospital, New York, NY, United States.
AN  - 33017083
AU  - Peltzer, B.
AU  - Manocha, K. K.
AU  - Ying, X.
AU  - Kirzner, J.
AU  - Ip, J. E.
AU  - Thomas, G.
AU  - Liu, C. F.
AU  - Markowitz, S. M.
AU  - Lerman, B. B.
AU  - Safford, M. M.
AU  - Goyal, P.
AU  - Cheung, J. W.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/jce.14770
DP  - NLM
ET  - 2020/10/06
J2  - Journal of cardiovascular electrophysiology
KW  - Atrial fibrillation
Covid-19
atrial flutter
mortality
outcomes
LA  - eng
N1  - 1540-8167
Peltzer, Bradley
Manocha, Kevin K
Ying, Xiaohan
Kirzner, Jared
Ip, James E
Orcid: 0000-0002-3461-505x
Thomas, George
Orcid: 0000-0001-7158-8305
Liu, Christopher F
Orcid: 0000-0001-8852-4551
Markowitz, Steven M
Orcid: 0000-0002-3401-8933
Lerman, Bruce B
Orcid: 0000-0001-6780-2903
Safford, Monika M
Goyal, Parag
Cheung, Jim W
Orcid: 0000-0002-4574-9360
Journal Article
United States
J Cardiovasc Electrophysiol. 2020 Oct 5. doi: 10.1111/jce.14770.
PY  - 2020
SN  - 1045-3873
ST  - Outcomes and Mortality Associated with Atrial Arrhythmias Among Patients Hospitalized with COVID-19
T2  - Journal of cardiovascular electrophysiology
TI  - Outcomes and Mortality Associated with Atrial Arrhythmias Among Patients Hospitalized with COVID-19
ID  - 7785163
ER  - 

TY  - JOUR
AB  - Individuals can test positive for SARS-CoV-2 by real-time polymerase chain reaction (RT-PCR) after no longer being infectious.1-8 Positive SARS-CoV-2 antigen-based testing exhibits a temporal pattern that corresponds with active, replicating virus and could therefore be a more accurate predictor of an individuals potential to transmit SARS-CoV-2.2,3,9 Using the BD Veritor System for Rapid Detection of SARS-CoV-2 later flow antigen detection test, we demonstrate a higher concordance of antigen-positive test results with the presence of cultured, infectious virus when compared to RT-PCR. When compared to infectious virus isolation, the sensitivity of antigen-based testing is similar to RT-PCR. The correlation between SARS-CoV-2 antigen and SARS-CoV-2 culture represents a significant advancement in determining the risk for potential transmissibility beyond that which can be achieved by detection of SARS-CoV-2 genomic RNA. Coupled with a rapid time-to-result, low cost, and scalability, antigen-based testing should facilitate effective implementation of testing and public health interventions that will better contain COVID-19.Competing Interest StatementCKC, VP, JCA, SK, JL, DSG, and CR-D are employees of Becton, Dickinson and Company. AP, ML, and YM received research funds to support their work for this study.Clinical TrialRegistration of this study at ClinicalTrials.gov was not obtained as it did not fulfill the applicable minimum medical device clinical trial requirement criteria as per the Food and Drug Administration Amendments Act. Specifically, this study did not assess health outcomes associated with the use of this assay.Funding StatementThis study was funded by Becton, Dickinson and Company; BD Life Sciences-Integrated Diagnostics Solutions. Non-BD employee authors received research funds to support their work for this study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Advarra IRBapproval--MOD00683499--29May2020 Becton Dickinson - BDX-GSCP01, Becton Dickinson Program for Collection of BioSpecimens (Pro00015576)All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesRequests for data related to this study should be sent to Charles K. Cooper at Becton, Dickinson and Company.
AU  - Pekosz, Andrew
AU  - Cooper, Charles
AU  - Parvu, Valentin
AU  - Li, Maggie
AU  - Andrews, Jeffrey
AU  - Manabe, Yukari C. C.
AU  - Kodsi, Salma
AU  - Leitch, Jeffry
AU  - Gary, Devin
AU  - Roger-Dalbert, Celine
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205708
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205708
ST  - Antigen-based testing but not real-time PCR correlates with SARS-CoV-2 virus culture (preprint)
T2  - medRxiv
TI  - Antigen-based testing but not real-time PCR correlates with SARS-CoV-2 virus culture (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205708.abstract
ID  - 7788872
ER  - 

TY  - JOUR
AU  - Peet, Lisa
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - As COVID-related budget cuts hit libraries, directors and deans must decide what their communities need most
T2  - Library Journal
TI  - As COVID-related budget cuts hit libraries, directors and deans must decide what their communities need most
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812940
ID  - 7788116
ER  - 

TY  - JOUR
AD  - Department of Bioscience and Bioinformatics, Khallikote University, Transit Campus: GMax Building, Konisi, Berhampur, Odisha, India.
AN  - 33011811
AU  - Pati, A.
AU  - Padhi, S.
AU  - Suvankar, S.
AU  - Panda, A. K.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1093/infdis/jiaa630
DP  - NLM
ET  - 2020/10/05
J2  - The Journal of infectious diseases
LA  - eng
N1  - 1537-6613
Pati, Abhijit
Padhi, Sunali
Suvankar, Subham
Panda, Aditya K
Journal Article
United States
J Infect Dis. 2020 Oct 3:jiaa630. doi: 10.1093/infdis/jiaa630.
PY  - 2020
SN  - 0022-1899
ST  - Minor allele of Interferon-Induced Transmembrane Protein-3 (IFITM3) polymorphism (rs12252) is covered against SARS-CoV-2 infection and mortality: a worldwide epidemiological investigation
T2  - Journal of infectious diseases
TI  - Minor allele of Interferon-Induced Transmembrane Protein-3 (IFITM3) polymorphism (rs12252) is covered against SARS-CoV-2 infection and mortality: a worldwide epidemiological investigation
ID  - 7785651
ER  - 

TY  - JOUR
AB  - The pandemic COVID-19 abruptly exploded, taking most health professionals around the world unprepared. Italy, the first European country to be hit violently, was forced to activate the lockdown in mid-February 2020. At the time of the spread, a high number of victims were quickly registered, especially in the regions of Northern Italy which have a high rate of highly-polluting production activities. The need to hospitalize the large number of patients with severe forms of COVID-19 led the National Health System to move a large number of specialists from their disciplines to the emergency hospital departments for the treatment of COVID-19. Furthermore, the lockdown itself has limited the possibility for general practitioners and pediatricians to be able to make outpatient visits and/or home care for patients with chronic diseases. Among them, the patient with atopic diseases, such as asthma, rhinitis and atopic dermatitis, is worthy of particular attention as she/he is immersed in a studded negative scenario with the onset of spring, a factor that should not be underestimated for those who suffer from pollen allergy. The Italian Society of Asthma Allergology and Clinical Immunology, to quickly deal with the lack of references and specialist medical procedures, has produced a series of indications for immunologic patient care that are reported in this paper, and can be used as guidelines by specialists of our discipline.
AD  - Division Allergy and Clinical Immunology, Department of Medicine, "Santa Maria Della Speranza" Hospital, Salerno, Italy.
Postgraduate Program in Allergy and Clinical Immunology, University of Naples Federico II, Naples, Italy. GRID: grid.4691.a. ISNI: 0000 0001 0790 385X
Department of Translational Medical Sciences, University of Naples Federico II, Naples, Italy. GRID: grid.4691.a. ISNI: 0000 0001 0790 385X
Respiratory Diseases Unit, Padua University and General Hospital, Padua, Italy. GRID: grid.5608.b. ISNI: 0000 0004 1757 3470
Asthma Center and Allergy Unit, Verona University and General Hospital, Verona, Italy. GRID: grid.5611.3. ISNI: 0000 0004 1763 1124
Chairman of Italian Society of Allergology, Asthma and Clinical Immunology (SIAAIC), Milan, Italy.
Center of Advanced Science and Technology, G. D'Annunzio University, Chieti-Pescara, Italy. GRID: grid.412451.7. ISNI: 0000 0001 2181 4941
Leonardo Da Vinci, University, Chieti, Italy.
AN  - 33020697
AU  - Patella, V.
AU  - Delfino, G.
AU  - Florio, G.
AU  - Spadaro, G.
AU  - Chieco Bianchi, F.
AU  - Senna, G.
AU  - Di Gioacchino, M.
C1  - 10/6/2020
C2  - PMC7528155
DB  - PubMed
DO  - 10.1186/s12948-020-00134-5
DP  - NLM
ET  - 2020/10/07
J2  - Clinical and molecular allergy : CMA
KW  - Allergy
Asthma
Autoimmune diseases
Covid-19
Immunodeficiencies
Personal protective equipment
Rhinitis
LA  - eng
N1  - Patella, Vincenzo
Orcid: 0000-0001-5640-6446
Delfino, Gabriele
Florio, Giovanni
Spadaro, Giuseppe
Chieco Bianchi, Fulvia
Senna, Gianerico
Di Gioacchino, Mario
Journal Article
Review
England
Clin Mol Allergy. 2020 Oct 1;18:18. doi: 10.1186/s12948-020-00134-5. eCollection 2020.
PY  - 2020
SN  - 1476-7961 (Print)
1476-7961
SP  - 18
ST  - Management of the patient with allergic and immunological disorders in the pandemic COVID-19 era
T2  - Clinical and molecular allergy : CMA
TI  - Management of the patient with allergic and immunological disorders in the pandemic COVID-19 era
VL  - 18
ID  - 7785005
ER  - 

TY  - JOUR
AD  - Department of Periodontics and Dental Hygiene, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX 77054, USA.
Department of General Practice and Dental Public Health, University of Texas Health Science Center at Houston, School of Dentistry, Houston, TX 77054, USA.
AN  - 33011983
AU  - Parsegian, K.
AU  - Ayilavarapu, S.
AU  - Gardner, A. L.
AU  - Angelov, N.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1002/jdd.12451
DP  - NLM
ET  - 2020/10/05
J2  - Journal of dental education
KW  - Covid-19
Curriculum Innovation
Periodontics
Undergraduate Dental
LA  - eng
N1  - 1930-7837
Parsegian, Karo
Orcid: 0000-0002-5440-6036
Ayilavarapu, Srinivas
Gardner, Amity L
Angelov, Nikola
Journal Article
United States
J Dent Educ. 2020 Oct 4. doi: 10.1002/jdd.12451.
PY  - 2020
SN  - 0022-0337
ST  - Predoctoral periodontal education and COVID-19: challenges, actions, and learned lessons
T2  - Journal of dental education
TI  - Predoctoral periodontal education and COVID-19: challenges, actions, and learned lessons
ID  - 7785634
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The pandemic caused by the novel coronavirus virus has altered all facets of clinical practice in the United States. The goal of this study is to better understand the impact of COVID-19 on rhinologic ambulatory and operative practice. METHODS: A 27-item survey to assess these objectives was created and approved by the Division of Rhinology faculty at Rush University Medical Center in April 2020. The survey was then distributed to rhinologists in a web based format via www.surveymonkey.com from April 10 through April 23, 2020. RESULTS: A total of 277 U.S based rhinologists responded to the survey (23.04%). The most common practice types were single specialty private (44.9%) and academic (24.6%). 90.2% practice in a state under a shelter in place order. Comparing pre-COVID baseline to during-COVID, there was statistically significant reduction in the number of patients of seen daily in clinic (p �?.001). The number of nasal endoscopies in the office and surgical procedures fell dramatically. Overall, 5 respondent rhinologists have been infected with COVID-19 and 27 have been furloughed. CONCLUSION: COVID-19 has drastically affected rhinologic practice. There is a dramatic reduction of in person care in the office setting and surgical management of sinonasal and skull base disease. Enhanced PPE is being used in only half of potentially aerosolizing procedures which represents an area of further education. Novel approaches such as use of virtual encounters and point of care testing should be considered as options to facilitate care.
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois.
Department of Otorhinolaryngology - Head and Neck Surgery, University of California Irvine, Irvine, California.
AN  - 33019817
AU  - Papagiannopoulos, P.
AU  - Ganti, A.
AU  - Kim, Y. J.
AU  - Raad, R. A.
AU  - Kuan, E. C.
AU  - Losavio, P.
AU  - Tajudeen, B. A.
AU  - Batra, P. S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/1945892420961962
DP  - NLM
ET  - 2020/10/07
J2  - American journal of rhinology & allergy
KW  - Covid-19
endoscopy
novel coronavirus
otolaryngology
pandemic
point of care testing
rhinology
sinus surgery
LA  - eng
N1  - 1945-8932
Papagiannopoulos, P
Orcid: 0000-0002-4209-9980
Ganti, A
Kim, Y J
Raad, R A
Kuan, E C
Orcid: 0000-0003-3475-0718
Losavio, P
Tajudeen, B A
Batra, P S
Journal Article
United States
Am J Rhinol Allergy. 2020 Oct 5:1945892420961962. doi: 10.1177/1945892420961962.
PY  - 2020
SN  - 1945-8932
SP  - 1945892420961962
ST  - Impact of COVID-19 Pandemic on Ambulatory and Operating Room Rhinology Practice in the US
T2  - American journal of rhinology & allergy
TI  - Impact of COVID-19 Pandemic on Ambulatory and Operating Room Rhinology Practice in the US
ID  - 7785087
ER  - 

TY  - JOUR
AB  - As a result of the various restrictions associated with the current COVID-19 pandemic, the practice of veterinary telehealth is likely to grow substantially. One area in which high quality care can be maintained while respecting physical distancing is teleconsulting, which describes the relationship between an attending and off-site consulting veterinarian. This guide uses a dentistry case to illustrate the provision of real-time anesthesia consulting, with a focus on the technological considerations central to facilitating live, 2-way video-communication. Case selection, teamwork, and patient safety are also discussed.
AD  - Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Alberta (DSJ Pang, JM Pang); Clinical Sciences, Faculty of Veterinary Medicine, Université de Montréal, St-Hyacinthe, Québec (DSJ Pang); Alberta Veterinary Dentistry, Calgary, Alberta (Payne, Faber); Oracle Corporation, Oracle Parkway, Reading, UK (Clement).
AN  - 33012826
AU  - Pang, D. S. J.
AU  - Pang, J. M.
AU  - Payne, O. J.
AU  - Clement, F. M.
AU  - Faber, T.
C1  - 10/6/2020
C2  - PMC7488381
DA  - Oct
DB  - PubMed
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - The Canadian veterinary journal = La revue veterinaire canadienne
LA  - eng
N1  - Pang, Daniel S J
Pang, Jessica M
Payne, Opal-Jane
Clement, Frazer M
Faber, Terrie
Journal Article
Review
Can Vet J. 2020 Oct;61(10):1092-1100.
PY  - 2020
SN  - 0008-5286 (Print)
0008-5286
SP  - 1092-1100
ST  - Teleconsulting in the time of a global pandemic: Application to anesthesia and technological considerations
T2  - Canadian veterinary journal = La revue veterinaire canadienne
TI  - Teleconsulting in the time of a global pandemic: Application to anesthesia and technological considerations
VL  - 61
ID  - 7785554
ER  - 

TY  - JOUR
AB  - PurposeInclusion of mobile nodes (MNs) in Internet of Things (IoT) further increases the challenges such as frequent network disconnection and intermittent connectivity because of high mobility rate of nodes. This paper aims to propose a proactive mobility and congestion aware route prediction mechanism (PMCAR) to find the congestion free route from leaf to destination oriented directed acyclic graph root (DODAG-ROOT) which considers number of MNs connected to a static node. This paper compares the proposed technique (PMCAR) with RPL (OF0) which considers the HOP-COUNT to determine the path from leaf to DODAG-ROOT. The authors performed a simulation with the proposed technique in MATLAB to present the benefits in terms of packet loss and energy consumption.Design/methodology/approachIn this pandemic situation, mobile and IoT play major role in predicting and preventing the CoronaVirus Disease of 2019 (COVID-19). Huge amount of computations is happening with the data generated in this pandemic with the help of mobile devices. To route the data to remote locations through the network, it is necessary to have proper routing mechanism without congestion. In this paper, PMCAR mechanism is introduced to achieve the same. Internet of mobile Things (IoMT) is an extension of IoT that consists of static embedded devices and sensors. IoMT includes MNs which sense data and transfer it to the DODAG-ROOT. The nodes in the IoMT are characterised by low power, low memory, low computing power and low bandwidth support. Several challenges are encountered by routing protocols defined for IPV6 over low power wireless personal area networks to ensure reduced packet loss, less delay, less energy consumption and guaranteed quality of service.FindingsThe results obtained shows a significant improvement compared to the existing approach such as RPL (OF0). The proposed route prediction mechanism can be applied largely to medical applications which are delay sensitive, particularly in pandemic situations where the number of patients involved and the data gathered from them flows towards a central root for analysis. Support of data transmission from the patients to the doctors without much delay and packet loss will make the response or decisions available more quickly which is a vital part of medical applications.Originality/valueThe computational technologies in this COVID-19 pandemic situation needs timely data for computation without delay. IoMT is enabled with various devices such as mobile, sensors and wearable devices. These devices are dedicated for collecting the data from the patients or any objects from different geographical location based on the predetermined time intervals. Timely delivery of data is essential for accurate computation. So, it is necessary to have a routing mechanism without delay and congestion to handle this pandemic situation. The proposed PMCAR mechanism ensures the reliable delivery of data for immediate computation which can be used to make decisions in preventing and prediction.
AN  - 2448231352
AU  - Pandi, Suganya
AU  - Pradeep Reddy, Ch
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1108/IJPCC-06-2020-0061
DP  - ProQuest Central
IS  - 5
KW  - Computers
QoS
Covid-19
IoMT
RPL
LNC-PP
MRPL
EC-MRPL
Wireless networks
Doctors
Computation
Protocol (computers)
Internet of Things
Sensors
Electronic devices
Nodes
Wearable technology
Data transmission
Viral diseases
Energy consumption
Traffic congestion
Computer simulation
Bandwidth
Simulation
Congestion
Delay
Pandemics
Traffic control
Power management
Embedded systems
Quality of service
Connectivity
Algorithms
Coronaviruses
Geographical locations
Decisions
Disease transmission
LA  - English
N1  - Copyright - © Emerald Publishing Limited 2020
PY  - 2020
SN  - 17427371
SP  - 429-446
ST  - PMCAR: proactive mobility and congestion aware route prediction mechanism in IoMT for delay sensitive medical applications to ensure reliability in COVID-19 pandemic situation
T2  - International Journal of Pervasive Computing and Communications
TI  - PMCAR: proactive mobility and congestion aware route prediction mechanism in IoMT for delay sensitive medical applications to ensure reliability in COVID-19 pandemic situation
UR  - https://www.proquest.com/docview/2448231352?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahightechjournals&atitle=PMCAR%3A+proactive+mobility+and+congestion+aware+route+prediction+mechanism+in+IoMT+for+delay+sensitive+medical+applications+to+ensure+reliability+in+COVID-19+pandemic+situation&title=International+Journal+of+Pervasive+Computing+and+Communications&issn=17427371&date=2020-01-01&volume=16&issue=5&spage=429&au=Pandi%2C+Suganya%3BPradeep+Reddy+Ch&isbn=&jtitle=International+Journal+of+Pervasive+Computing+and+Communications&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1108%2FIJPCC-06-2020-0061
VL  - 16
ID  - 7784955
ER  - 

TY  - JOUR
AB  - The COVID-19 diagnostic approach is mainly divided into two broad categories, a laboratory-based and chest radiography approach. The last few months have witnessed a rapid increase in the number of studies use artificial intelligence (AI) techniques to diagnose COVID-19 with chest computed tomography (CT). In this study, we review the diagnosis of COVID-19 by using chest CT toward AI. We searched ArXiv, MedRxiv, and Google Scholar using the terms "deep learning", "neural networks", "COVID-19", and "chest CT". At the time of writing (August 24, 2020), there have been nearly 100 studies and 30 studies among them were selected for this review. We categorized the studies based on the classification tasks: COVID-19/normal, COVID-19/non-COVID-19, COVID-19/non-COVID-19 pneumonia, and severity. The sensitivity, specificity, precision, accuracy, area under the curve, and F1 score results were reported as high as 100%, 100%, 99.62, 99.87%, 100%, and 99.5%, respectively. However, the presented results should be carefully compared due to the different degrees of difficulty of different classification tasks.
AD  - Department of Biomedical Engineering, Near East University, Nicosia / TRNC, Mersin-10, 99138, Turkey.
DESAM Institute, Near East University, Nicosia / TRNC, Mersin-10, 99138, Turkey.
Department of Artificial Intelligence Engineering, Near East University, Nicosia / TRNC, Mersin-10, 99138, Turkey.
AN  - 33014121
AU  - Ozsahin, I.
AU  - Sekeroglu, B.
AU  - Musa, M. S.
AU  - Mustapha, M. T.
AU  - Uzun Ozsahin, D.
C1  - 10/6/2020
C2  - PMC7519983 of this paper.
DB  - PubMed
DO  - 10.1155/2020/9756518
DP  - NLM
ET  - 2020/10/06
J2  - Computational and mathematical methods in medicine
LA  - eng
N1  - 1748-6718
Ozsahin, Ilker
Orcid: 0000-0002-3141-6805
Sekeroglu, Boran
Orcid: 0000-0001-7284-1173
Musa, Musa Sani
Orcid: 0000-0003-0068-074x
Mustapha, Mubarak Taiwo
Uzun Ozsahin, Dilber
Orcid: 0000-0002-3873-1410
Journal Article
Comput Math Methods Med. 2020 Sep 26;2020:9756518. doi: 10.1155/2020/9756518. eCollection 2020.
PY  - 2020
SN  - 1748-670X (Print)
1748-670x
SP  - 9756518
ST  - Review on Diagnosis of COVID-19 from Chest CT Images Using Artificial Intelligence
T2  - Computational and mathematical methods in medicine
TI  - Review on Diagnosis of COVID-19 from Chest CT Images Using Artificial Intelligence
VL  - 2020
ID  - 7785421
ER  - 

TY  - JOUR
AB  - PURPOSE: The aim of our study is to evaluate the incidence and characteristics of otolaryngology symptoms in COVID 19 patients. METHODS: 116 patients with positive PCR test results for COVID-19 and followed up by otolaryngologists at a tertiary referral center/COVID-19 pandemic hospital were questioned in terms of otolaryngology symptoms associated with COVID-19 infection. Data including demographics, disease severity, concomitant diseases, previous otolaryngologic diseases,incidence and duration of new onset symptoms were collected and categorically analyzed. In addition, the severity of loss of smell and taste was evaluated by visual analogue score (VAS). RESULTS: A total of 58 men and 58 women participated. The mean age of the patients was 57.24 ±�?4.32 (19-83). The most common otolaryngological findings were hyposmia/anosmia (37.9%) and hypogeusia/ageusia (41.37%), respectively. These complaints were followed by headache (37.1%), and nausea/vomiting (31%). The most common oropharyngeal symptoms were sore throat (32.7%) and dysphagia (20.6%). The rate of otological/vestibular symptoms was dizziness (31.8%), tinnitus (11%), true vertigo (6%), and hearing impairment (5.1%), respectively. The most of symptoms were more frequent in �?0 years and women. There was a significant correlation between nasal itching and smell disturbance in patients with allergic rhinitis. Considering the duration of symptoms, the longest were hyposmia/anosmia and hypogeusia/ageusia. The mean VAS's in patients with hyposmia/anosmia and hypogeusia/ageusia were 5.52 ±�?.08 and 5.79 ±�?.21, respectively. CONCLUSION: The most common otolaryngologic symptoms of COVID-19 infection are known as sore throat, smell and/or taste disturbances. However, our study showed that these patients can be seen with different symptoms in otological or laryngeal areas. Therefore, a more careful evaluation should be made in terms of otolaryngologic symptoms when COVID 19 infection is suspected.
AD  - Sakarya University Medical Faculty Traning and Research Hospital, Otolaryngology Department, Korucuk Campus, Korucuk, 54290, Sakarya, Turkey. ozcelikmuge@gmail.com.
Sakarya University Medical Faculty Traning and Research Hospital, Otolaryngology Department, Korucuk Campus, Korucuk, 54290, Sakarya, Turkey.
AN  - 33011957
AU  - Özçelik Korkmaz, M.
AU  - Eğilmez, O. K.
AU  - Özçelik, M. A.
AU  - Güven, M.
C1  - 10/6/2020
C2  - PMC7532931
DA  - Oct 3
DB  - PubMed
DO  - 10.1007/s00405-020-06396-8
DP  - NLM
ET  - 2020/10/05
J2  - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
KW  - Allergic rhinitis
Covid-19
Otology
Rhinology
Throat
Vertigo
LA  - eng
N1  - 1434-4726
Özçelik Korkmaz, Müge
Orcid: 0000-0003-4726-7987
Eğilmez, Oğuz Kadir
Orcid: 0000-0003-2395-1098
Özçelik, Muhammet Ali
Orcid: 0000-0001-5587-9882
Güven, Mehmet
Orcid: 0000-0002-3665-2428
Journal Article
Eur Arch Otorhinolaryngol. 2020 Oct 3:1-11. doi: 10.1007/s00405-020-06396-8.
PY  - 2020
SN  - 0937-4477 (Print)
0937-4477
SP  - 1-11
ST  - Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection
T2  - European archives of oto-rhino-laryngology : official journal of European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
TI  - Otolaryngological manifestations of hospitalised patients with confirmed COVID-19 infection
ID  - 7785639
ER  - 

TY  - JOUR
AB  - Introduction In the last 18 years, on three occasions, coronavirus has represented a challenge for global health Between 2002 and 2003 with Severe Acute Respiratory Syndrome, in 2012 with Middle East Respiratory Syndrome, and since the end of 2019 with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) pandemic, which has challenged health care models and the way of doing research, placing bioethics at the center of discussion Methods On August 19, 2020, a webinar organized by the Research Institute of Medical Science (IICIMED, for its acronym in Spanish), entitled &#039;Bioethical Implications in Vaccine Development, a COVID-19 Challenge&#039; took place Three experts spoke about the importance of bioethics in the race to develop a COVID-19 vaccine, the risk involved in shortening the terms of the clinical trial phases, and how the associated risks can be minimized, in order to expedite research results Conclusion With the novel SARS-CoV-2 coronavirus, critical challenges have been posed not only for public health but for research and the scientific community A safe and effective vaccine is urgently needed to prevent COVID-19 transmission, complications, and deaths;the adherence to ethical principles required by clinical research is mandatory and closer supervision is also essential
AU  - Ospina Henao, Sebastian
AU  - Marin Mora, Alejandro
AU  - Chan Solano, Fanny
AU  - Avila-Aguero, Maria L.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Bioethical Implications in Vaccine Development, a COVID-19 Challenge
T2  - Cureus
TI  - Bioethical Implications in Vaccine Development, a COVID-19 Challenge
UR  - https://doi.org/10.7759/cureus.10530
ID  - 7788410
ER  - 

TY  - JOUR
AB  - Coronavirus illness 2019 (COVID-19) is an airways infection caused by the new coronavirus (SARS-CoV-2) which has been quickly disseminated all over the world, affecting to the general population including women in pregnancy time. As being a recent infection, the evidence that supports the best practices for the management of the infection during pregnancy is limited, and most of the questions have not been completely solved yet. This publication offers general guidelines focused on decision-making people, managers, and health's teams related to pregnant women attention and newborn babies during COVID-19 pandemic. Its purpose is to promote useful interventions to prevent new infections as well as prompt and adequate attention to avoid serious complications or deaths, trying to be adapted to the different contexts in which attention to expectant mothers is provided. Guidelines are set within a well-scientific evidence and available recommendations up to date.
AD  - Universidad del Valle, Facultad de Salud, Escuela de Medicina, Departamento de Obstetricia y Ginecolog�Ta. Cali, Colombia.
Centro Medico Imbanaco, Cali, Colombia.
Centro Médico Imbanaco, Direcci�Qn Cient�Tfica. Cali, Colombia.
AN  - 33012886
AU  - Ortiz, E. I.
AU  - Herrera, E.
AU  - De La Torre, A.
C1  - 10/6/2020
C2  - PMC7518733
DA  - Jun 30
DB  - PubMed
DO  - 10.25100/cm.v51i2.4271
DP  - NLM
ET  - 2020/10/06
IS  - 2
J2  - Colombia medica (Cali, Colombia)
KW  - Covid-19
Symptomatic expectant mothers
Symptomless expectant mothers
childbirth
lactation
newborn
LA  - eng
N1  - 1657-9534
Ortiz, Edgar Iv֙n
Orcid: 0000-0001-8625-659x
Herrera, Enrique
Orcid: 0000-0003-1308-8083
De La Torre, Alejandro
Orcid: 0000-0002-3902-5294
Journal Article
Review
Colomb Med (Cali). 2020 Jun 30;51(2):e4271. doi: 10.25100/cm.v51i2.4271.
PY  - 2020
SN  - 0120-8322 (Print)
0120-8322
SP  - e4271
ST  - Coronavirus (COVID 19) Infection in Pregnancy
T2  - Colombia medica (Cali, Colombia)
TI  - Coronavirus (COVID 19) Infection in Pregnancy
VL  - 51
ID  - 7785541
ER  - 

TY  - JOUR
AB  - PURPOSE OF REVIEW: Increased focus on patient-centered outcomes, mental health, and delirium prevention makes this review timely and relevant for critical care. RECENT FINDINGS: This review focuses on patient-centered outcomes in the ICU, highlighting the latest research to promote brain health and psychological recovery during and after perioperative critical illness. Topics include sedation in the obese patient, delirium severity assessments, the role of the Psychiatry Consultation-Liaison in the ICU, Post-intensive care syndrome, and the importance of family engagement in the COVID era. SUMMARY: Highlighting new research, such as novel implementation strategies in addition to a lack of research in certain areas like sleep in the ICU may lead to innovation and establishment of evidence-based practices in critical care. Perioperative brain health is multifaceted, and an increase in multidisciplinary interventions may help improve outcomes and decrease morbidity in ICU survivors.
AU  - Ortiz, Damaris
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - en
PY  - 2020
ST  - Assessment and management of agitation, sleep, and mental illness in the surgical ICU
T2  - Current Opinion in Critical Care
TI  - Assessment and management of agitation, sleep, and mental illness in the surgical ICU
UR  - https://dx.doi.org/10.1097/MCC.0000000000000762
ID  - 7788636
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic threatens to set back major successes that have been achieved in global vaccine initiatives. We conducted a rapid review and synthesis of the literature on immunization provision and Utilization since the onset of the COVID-19 pandemic. A total of 11 papers comprising peer-reviewed articles and key policies and guidelines, published between January 1 and June 15, 2020, were analyzed. Widespread disruptions of routine immunization and vaccination campaigns were reported leaving millions of children worldwide at risk of measles outbreaks. We present an expanded model of the World Health Organization's Global Routine Immunization Strategic Plan (GRISP) action areas as a tool to help countries quickly adapt to immunization challenges in the presence of COVID-19 and close the emerging immunization coverage gaps.
AD  - Department of Public Health, Arcadia University, Glenside, PA, USA.
College of Nursing and Public Health, Adelphi University, Garden City, NY, USA.
Department of Family and Community Medicine; and Center of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, Houston, TX, USA.
AN  - 33014624
AU  - Olorunsaiye, C. Z.
AU  - Yusuf, K. K.
AU  - Reinhart, K.
AU  - Salihu, H. M.
C1  - 10/6/2020
C2  - PMC7520883
DB  - PubMed
DO  - 10.21106/ijma.401
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - International journal of MCH and AIDS
KW  - Covid-19
Child health
Corona virus
Essential health services
Immunization
Vaccination
LA  - eng
N1  - 2161-864x
Olorunsaiye, Comfort Z
Yusuf, Korede K
Reinhart, Kylie
Salihu, Hamisu M
Journal Article
Int J MCH AIDS. 2020;9(3):381-385. doi: 10.21106/ijma.401. Epub 2020 Sep 15.
PY  - 2020
SN  - 2161-8674 (Print)
2161-864x
SP  - 381-385
ST  - COVID-19 and Child Vaccination: A Systematic Approach to Closing the Immunization Gap
T2  - International journal of MCH and AIDS
TI  - COVID-19 and Child Vaccination: A Systematic Approach to Closing the Immunization Gap
VL  - 9
ID  - 7785387
ER  - 

TY  - JOUR
AB  - Background: An understanding of willingness of people to disclose coronavirus disease 2019 (COVID-19) symptoms and take the COVID-19 test will help provide important insight for motivators towards the self-surveillance and testing strategies recommended by the World Health Organization to curtail and halt the transmission of COVID-19. Objectives: This study assessed willingness to disclose symptoms suggestive of COVID-19 and willingness to take COVID-19 test as well as their predictors. Methods: A cross-sectional online survey of 524 Nigerian adults, aged �?18 years, residing in Nigeria and who had not taken the COVID-19 test was conducted. Information on willingness to disclose COVID-19 symptoms, take COVID-19 test and possible predictors were collected. Data were analysed using descriptive and inferential statistics evaluated at 5% significance level. Results: Mean age of respondents was 35.8 (S.D: 10.7) years and 57.0% were males. Majority (85.8% and 86.2% respectively) were willing to disclose COVID-19 symptoms and take COVID-19 test. Self-risk perception of contracting COVID-19 predicted both willingness to disclose COVID-19 symptoms (aOR=3.236; 95%CI=1.836-5.704) and take COVID-19 test (aOR=3.174; 95%CI=1.570-6.419). Willingness to disclose COVID-19 symptoms (aOR=13.060; 95%CI= 6.253-27.276), knowledge of someone who had taken the test (aOR= 4.106; 95%CI= 1.179-14.299) and thought that it was important for people to know their COVID-19 status (aOR=3.123; 95%CI= 1.516-6.434) also predicted willingness to take COVID-19 test. Conclusion: Nigerians are willing to disclose symptoms suggestive of COVID-19 and take the COVID-19 test. Investment in interventions developed based on the predicting factors will help speed up the finding and testing of suspected COVID-19 cases.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe authors declare that this work was not fundedAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Ethical approval to conduct the study was obtained from the Ondo State Health Research Ethics Committee with study protocol number OSHREC/28/05/20/268.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data referred to in the manuscript are available upon request
AU  - Oladoyin, Victoria Oluwabunmi
AU  - Okunlola, Oluyemi Adewole
AU  - Israel, Oluwaseyi Kikelomo
AU  - Ibirongbe, Demilade Olusola
AU  - Osifo, Joy Atonirehonmon
AU  - Obembe, Taiwo Akinyode
AU  - Omode, Paulinus Kunle
AU  - Osunmakinwa, Olugbenga Olusegun
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205914
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205914
ST  - Willingness of Nigerian residents to disclose COVID-19 symptoms and take COVID-19 test (preprint)
T2  - medRxiv
TI  - Willingness of Nigerian residents to disclose COVID-19 symptoms and take COVID-19 test (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205914.abstract
ID  - 7788868
ER  - 

TY  - JOUR
AB  - Background and objectives: the emergency department (ED) is frequently identified by patients as a possible solution for all healthcare problems, leading to a high rate of misuse of the ED, possibly causing overcrowding. The coronavirus disease 2019 (COVID-19) pandemic started in China; it then spread throughout Italy, with the first cases confirmed in Lombardy, Italy, in February 2020. This has totally changed the type of patients referred to EDs. The aim of this study was to analyze the reduction of ED admissions at a Second level urban teaching (Fondazione Policlinico Universitario Agostino Gemelli IRCCS) during the COVID-19 pandemic. Materials and Methods: in this retrospective observational cross-sectional study, we reviewed and compared clinical records of all the patients consecutively admitted to our ED over a 40-day period (21 February -31 March) in the last three years (2018-2019-2020). Mean age, sex, triage urgency level, day/night admission, main presentation symptom, and final diagnosis, according to different medical specialties, hospitalization, and discharge rate, were analyzed. Results: we analyzed 16,281 patient clinical records. The overall reduction in ED admissions in 2020 was 37.6% compared to 2019. In 2020, we observed an increase in triage urgency levels for ED admissions (the main presentation symptom was a fever). We noticed a significant drop in admissions for cardio-thoracic, gastroenterological, urological, otolaryngologic/ophthalmologic, and traumatological diseases. Acute neurological conditions registered only a slight, but significant, reduction. Oncology admissions were stable. Admissions for infectious diseases were 30% in 2020, compared to 5% and 6% in 2018 and 2019, respectively. In 2020, the hospitalization rate increased to 42.9% compared to 27.7%, and 26.4% in previous years. Conclusions: the drastic reduction of ED admissions during the pandemic may be associated with fear of the virus, suggesting that patients with serious illnesses did not go to the emergency room. Moreover, there was possible misuse of the ED in the previous year. In particular, worrisome data emerged regarding a drop in cardiology and neurology admissions. Those patients postponed medical attention, possibly with fatal consequences, just for fear of exposure to COVID-19, leading to unnecessary morbidity and mortality.
AD  - Emergency Department-Fondazione Policlinico Universitario A. Gemelli, IRCCS-Largo A. Gemelli, 00168 1 Rome, Italy.
Università Cattolica del Sacro Cuore-Largo F. Vito, 00168 1 Rome, Italy.
Ospedale Cristo Re, Emergency Department-Via delle Calasanziane, 00168 25 Rome, Italy.
AN  - 33019514
AU  - Ojetti, V.
AU  - Covino, M.
AU  - Brigida, M.
AU  - Petruzziello, C.
AU  - Saviano, A.
AU  - Migneco, A.
AU  - Candelli, M.
AU  - Franceschi, F.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/medicina56100512
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Medicina (Kaunas, Lithuania)
KW  - Covid-19
Emergency department access
fever
misuse
LA  - eng
N1  - 1648-9144
Ojetti, Veronica
Covino, Marcello
Orcid: 0000-0002-6709-2531
Brigida, Mattia
Petruzziello, Carmine
Saviano, Angela
Migneco, Alessio
Orcid: 0000-0001-8901-932x
Candelli, Marcello
Orcid: 0000-0001-8443-7880
Franceschi, Francesco
Journal Article
Switzerland
Medicina (Kaunas). 2020 Oct 1;56(10):E512. doi: 10.3390/medicina56100512.
PY  - 2020
SN  - 1010-660x
ST  - Non-COVID Diseases during the Pandemic: Where Have All Other Emergencies Gone?
T2  - Medicina (Kaunas, Lithuania)
TI  - Non-COVID Diseases during the Pandemic: Where Have All Other Emergencies Gone?
VL  - 56
ID  - 7785098
ER  - 

TY  - JOUR
AB  - A pandemic such as COVID-19 can cause a sudden depletion of the worldwide supply of respirators, forcing healthcare providers to reuse them In this study, we systematically evaluated dry heat treatment as a viable option for the safe decontamination of N95 respirators (1860, 3M) before their reuse We found that the dry heat generated by an electric cooker (100 degrees C, 5% relative humidity, 50 min) effectively inactivated Tulane virus (TV, &amp;gt;5 2-log(10) reduction), rotavirus (RV, &amp;gt;6 6-log10 reduction), adenovirus (AdV, &amp;gt;4 0-log(10) reduction), and transmissible gastroenteritis virus (TGEV, &amp;gt;4 7-log(10) reduction) The respirator integrity (determined on the basis of the particle filtration efficiency and quantitative fit testing) was not compromised after 20 cycles of a 50 min dry heat treatment On the basis of these results, dry heat decontamination generated by an electric cooker (e g , rice cookers, instant pots, and ovens) could be an effective and accessible decontamination method for the safe reuse of N95 respirators We recommend users measure the temperature during decontamination to ensure the respirator temperature can be maintained at 100 degrees C for 50 min
AU  - Oh, Chamteut
AU  - Araud, Elbashir
AU  - Puthussery, Joseph V.
AU  - Bai, Hezi
AU  - Clark, Gemma G.
AU  - Wang, Leyi
AU  - Verma, Vishal
AU  - Nguyen, Thanh H.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Dry Heat as a Decontamination Method for N95 Respirator Reuse
T2  - Environmental Science & Technology Letters
TI  - Dry Heat as a Decontamination Method for N95 Respirator Reuse
UR  - https://doi.org/10.1021/acs.estlett.0c00534
ID  - 7788209
ER  - 

TY  - JOUR
AD  - Instituto Alexander Fleming, 1180 Cr֙mer St., Buenos Aires, Argentina.
AN  - 33014141
AU  - O'Connor, J. M.
AU  - Esteso, F.
AU  - Chac�Qn, M.
C1  - 10/6/2020
C2  - PMC7524005 or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
DA  - May
DB  - PubMed
DO  - 10.2217/crc-2020-0018
DP  - NLM
ET  - 2020/10/06
IS  - 2
J2  - Colorectal cancer
LA  - eng
N1  - 1758-1958
O'Connor, Juan Manuel
Orcid: 0000-0002-6975-5466
Esteso, Federico
Chac�Qn, Mat�Tas
Journal Article
Colorectal Cancer. 2020 May;9(2):CRC21. doi: 10.2217/crc-2020-0018.
PY  - 2020
SN  - 1758-194X (Print)
1758-194x
SP  - Crc21
ST  - Official French SARS-CoV-2 guidelines for cancer patients, a triage solution with precision medicine
T2  - Colorectal cancer
TI  - Official French SARS-CoV-2 guidelines for cancer patients, a triage solution with precision medicine
VL  - 9
ID  - 7785419
ER  - 

TY  - JOUR
AB  - BACKGROUND: Cardiovascular diseases, cancer, type-2 diabetes and chronic obstructive pulmonary disease (COPD) were initially noted as the most common diseases among individuals who were hospitalised for COVID-19. However, the evidence base is weak. The objective of this study is to describe how selected diseases were distributed among adults with confirmed COVID-19 (COVID-19 positive tests) and among those hospitalised for COVID-19 compared to the general population. MATERIAL AND METHOD: We used data from the Norwegian Patient Registry, the Norwegian Registry for Primary Health Care and the Norwegian Surveillance System for Communicable Diseases for adults from the age of 20 and older for the period 1 March 2020-13 May 2020. RESULTS: Of all those who tested positive for COVID-19, 7 632 (94 %) were aged 20 years or older, and 1 025 (13.4 %) of these had been hospitalised. Among those hospitalised with COVID-19, there was a higher proportion of individuals with cardiovascular diseases (18.3 % versus 15.6 %), cancer (6.9 % versus 5.4 %), type-2 diabetes (8.6 % versus 5.2 %) and COPD (3.8 % versus 2.7 %) than in the general population as a whole after adjusting for age. The proportion of hospitalised patients with asthma, other chronic respiratory disease, cardiovascular disease, ongoing cancer treatment, complications related to hypertension, obesity and overweight, neurological disorders and cardiac and renal failure was also higher than in the general population. There were few differences between persons who had tested positive for COVID-19 and the general population in terms of underlying conditions. INTERPRETATION: Among those hospitalised for COVID-19, there was a higher proportion of patients with underlying illnesses than in the general population. This may indicate that these patients tend to have a more severe course of disease or that they are more likely to be hospitalised compared to healthy individuals. The results must be interpreted with caution, since the sample of COVID-19 individuals is non-random.
AU  - Nystad, Wenche
AU  - Hjellvik, Vidar
AU  - Larsen, Inger Kristin
AU  - Ariansen, Inger
AU  - Helland, Eyvind
AU  - Johansen, Knut Ivar
AU  - Gulbrandsen, Johanne
AU  - Gulseth, Hanne Løvdal
AU  - Eide, Helena Niemi
AU  - Håberg, Siri E.
AU  - Karlstad, Øystein
AU  - Bakken, Inger Johanne
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 13
LA  - nor
PY  - 2020
ST  - Underliggende tilstander hos voksne med covid-19
T2  - Journal of the Norwegian Medical Association
TI  - Underliggende tilstander hos voksne med covid-19
TT  - Underliggende tilstander hos voksne med covid-19.
Underlying conditions in adults with COVID-19.
UR  - https://dx.doi.org/10.4045/tidsskr.20.0512
VL  - 140
ID  - 7788775
ER  - 

TY  - JOUR
AB  - AbstrakCOVID-19 telah menjadi pandemik di Indonesia sejak ditemukannya kasus pertama pada tanggal 2 Maret 2020 di Depok. Peningkatan kasus perhari semakin tinggi sejak akhir Agustus 2020 yang mencapai lebih dari 2000 kasus per hari. Sistem kesehatan di Indonesia perlu ditingkatkan dalam hal kapasitas, termasuk rehabilitasi medik yang harus dilibatkan dari fase akut hingga jangka panjang dalam penanganan pasien COVID-19. Rehabilitasi medik juga diperlukan untuk pasien lain yang bukan COVID-19. Pentingnya keterlibatan, pelayanan rehabilitasi medik dan implementasinya dimasa pandemic COVID-19 memerlukan strategi tersendiri yang harus dilakukan baik oleh pekerja kesehatannya, rumah sakit dan kebijakan pemerintah. Hal ini diperlukan untuk percepatan peningkatan kesehatan pasien, percepatan pemulangan dan menghindari readmisi pasien, dan juga pengoptimalan program kembali bekerja untuk pasien yang sembuh dari COVID-19.AbstractCOVID-19 has become a pandemic in Indonesia since the first cases have been positively diagnosed on 2 March 2020 in Depok. The cases have been increased gradually since the end of August 2020 that has reached 1000 cases per day. The health system in Indonesia needs to be improved in terms of capacity, including rehabilitation medicine that should be involved in all health phases (from acute to long-term) in managing patients with COVID-19. Rehabilitation is also still needed for other non-COVID-19 patients. The importance of involvement and implementation of rehabilitation services during the COVID-19 pandemic will need special strategies that should be done by rehabilitation professionals, hospitals, and government. These are necessary to accelerate the improvement of patients' health, discharge, and avoid re-admission, as well as optimize return-to-work for patients who are recovered from COVID-19.
AD  - Department of Rehabilitation Medicine, Hannover Medical School, Hannover. boya.nugraha@gmail.com.
AN  - 33020342
AU  - Nugraha, B.
AU  - Wahyuni, L. K.
AU  - Laswati, H.
AU  - Kusumastuti, P.
AU  - Tulaar, A. B.
AU  - Gutenbrunner, C.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
Indonesia
health care
pandemic
rehabilitation
rehabilitation services
LA  - eng
N1  - Nugraha, Boya
Wahyuni, Luh Karunia
Laswati, Hening
Kusumastuti, Peni
Tulaar, Angela Bm
Gutenbrunner, Christoph
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):299-305.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 299-305
ST  - COVID-19 pandemic in Indonesia: Situation and challenges of rehabilitation medicine in Indonesia
T2  - Acta medica Indonesiana
TI  - COVID-19 pandemic in Indonesia: Situation and challenges of rehabilitation medicine in Indonesia
VL  - 52
ID  - 7785028
ER  - 

TY  - JOUR
AB  - BACKGROUND: The ongoing SARS-CoV-2 pandemic presents a unique challenge to diagnostic laboratories. There are preliminary studies correlating qRT-PCR results from different materials to clinical outcomes, yet, comparability is limited due to the plethora of different assays used for diagnostics. In this study we evaluate clinical performance and linear range for the SARS-CoV-2 IVD (cobas6800/8800 system, a fully automated sample-to-result platform) in different clinically relevant matrix materials outside official specifications. METHODS: Assay performance was assessed in human plasma, BAL/BL and transport medium following chemical inactivation. For analytical evaluation, respective matrix materials were spiked with SARS-CoV-2 RNA in ten-fold dilution series. The efficacy of chemical inactivation by guanidine hydrochloride solution was confirmed in cell culture infectivity experiments. For correlation, a total of 289 predetermined clinical samples including respiratory swabs, plasma and lower respiratory tract specimens were subjected to the SARS-CoV-2 IVD test and results were compared. RESULTS: The SARS-CoV-2 IVD showed excellent linearity over four to six log steps depending on matrix material. Chemical inactivation resulted in a reduction in plaque forming units of at least 3.5 log steps, while having no significant impact on assay performance. Inter-run consistency from three different testing sites demonstrated excellent comparability of RT-PCR results (maximum deviation was 1.53 CT). Clinical evaluation for respiratory swabs showed very good agreement with the comparator assay (Positive agreement 95.7 %, negative agreement 98.9 %). CONCLUSION: The SARS-CoV-2 IVD test for the cobas6800/8800 systems offers excellent linear range and inter-run consistency for quantification of SARS-CoV-2 RNA in different matrices outside official specifications.
AD  - University Medical Center Hamburg-Eppendorf (UKE), Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany.
Labor Stein, Mönchengladbach, Germany.
Labor Limbach, Heidelberg, Germany.
Bernhard Nocht Institute, Leibniz Institute for Tropical Medicine, Hamburg, Germany; German Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck-Riems, Germany.
University Medical Center Hamburg-Eppendorf (UKE), Department of Intensive Care, Hamburg, Germany.
University Medical Center Hamburg-Eppendorf (UKE), Institute of Medical Microbiology, Virology and Hygiene, Hamburg, Germany; German Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck-Riems, Germany. Electronic address: mluetgeh@uke.de.
AN  - 33011643
AU  - Nörz, D.
AU  - Frontzek, A.
AU  - Eigner, U.
AU  - Oestereich, L.
AU  - Wichmann, D.
AU  - Kluge, S.
AU  - Fischer, N.
AU  - Aepfelbacher, M.
AU  - Pfefferle, S.
AU  - Lütgehetmann, M.
C1  - 10/6/2020
C2  - PMC7510425
DA  - Sep 23
DB  - PubMed
DO  - 10.1016/j.jcv.2020.104650
DP  - NLM
ET  - 2020/10/05
J2  - Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
KW  - Covid-19
Cobas 6800
Molecular diagnostics
Quantification
Rt-pcr
SARS-CoV-2
LA  - eng
N1  - 1873-5967
Nörz, Dominik
Frontzek, André
Eigner, Ulrich
Oestereich, Lisa
Wichmann, Dominic
Kluge, Stefan
Fischer, Nicole
Aepfelbacher, Martin
Pfefferle, Susanne
Lütgehetmann, Marc
Journal Article
J Clin Virol. 2020 Sep 23;132:104650. doi: 10.1016/j.jcv.2020.104650.
PY  - 2020
SN  - 1386-6532 (Print)
1386-6532
SP  - 104650
ST  - Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations
T2  - Journal of clinical virology : official publication of Pan American Society for Clinical Virology
TI  - Pushing beyond specifications: Evaluation of linearity and clinical performance of the cobas 6800/8800 SARS-CoV-2 RT-PCR assay for reliable quantification in blood and other materials outside recommendations
VL  - 132
ID  - 7785668
ER  - 

TY  - JOUR
AB  - There is increasing evidence that children and adolescents can efficiently transmit SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19) (1�?). During July–August 2020, four state health departments and CDC investigated a COVID-19 outbreak that occurred during a 3-week family gathering of five households in which an adolescent aged 13 years was the index and suspected primary patient; 11 subsequent cases occurred.

Both heads of each household were interviewed to assess demographic characteristics, exposures, symptoms, close contacts, and outcomes. Parents provided data for all children, adolescents, and young adults. Thirteen of the index patient’s relatives sought viral testing; test results were reported by respondents, and all test results that were reported to be positive were verified in state reporting systems. For three children and adolescents who were not tested while symptomatic, a chemiluminescent immunoassay* detecting total antibody to SARS-CoV-2 was performed 28�?6 days after symptom onset; results were positive for all three children and adolescents, including the index patient and her two brothers, indicating earlier infection. Likely exposure periods�?and infectious periods�� were estimated from symptom onset dates. This activity was reviewed by CDC and was conducted consistent with applicable federal law and CDC policy.¶

While away from home, the index patient was exposed during a large COVID-19 outbreak in June 2020. Because of her exposure, she sought testing for SARS-CoV-2 after returning home. A rapid antigen test performed 4 days after exposure, when she was asymptomatic, was negative (Table) (Figure). She experienced nasal congestion 2 days later, her only symptom. That same day, she, her parents, and two brothers traveled to a gathering with 15 other relatives, which began the following day. Attendees belonged to five households in four states and ranged in age from 9 to 72 years. Fourteen relatives, including the index patient, stayed in a five-bedroom, two-bathroom house for 8�?5 days. These relatives did not wear face masks or practice physical distancing. An additional six relatives (an aunt, an uncle, and four cousins) visited for 10 hours on day 3 and 3 hours on day 10, when six overnight attendees were potentially infectious, but maintained physical distance and remained outdoors; none wore face masks.

Among the 14 persons who stayed in the same house, 12 experienced symptoms** and were subsequently found to have COVID-19 based on Council of State and Territorial Epidemiologists definitions.†�?Six cases were confirmed by reverse transcription–polymerase chain reaction (RT-PCR) testing, four persons were classified as having probable COVID-19 based on positive antigen testing or clinical and epidemiologic criteria, and two persons were classified as having suspected COVID-19 based on positive antibody testing, including the index patient (Table). The other two overnight attendees never experienced symptoms, including one who received a negative SARS-CoV-2 RT-PCR test result 4 days after the last exposure. One person with COVID-19 was hospitalized and another sought emergency department care for respiratory symptoms; both recovered. None of the six relatives who remained outdoors and maintained physical distance developed symptoms; four had negative RT-PCR test results 4 days after the last exposure, and two were not tested. Relatives with COVID-19 were advised by state investigators to self-isolate, and contacts were advised to self-quarantine.

Eight relatives reported activities outside the gathering during their exposure periods that might have increased their risks for exposure. However, only the index patient reported exposure to a person with confirmed COVID-19 or compatible symptoms outside the family. The index patient’s high-risk exposure and symptom onset 3�?9 days before that of any other person at the family gathering support the hypothesis that this adolescent’s infection was the source of the family outbreak (Figure). The adolescent’s initial antigen test result was likely a false negative because it was performed before symptom onset; the only antigen test that had Food and Drug Administration Emergency Use Authorization at the time was intended for use within the first 5 days of symptoms.����

This outbreak highlights several important issues. First, children and adolescents can serve as the source for COVID-19 outbreaks within families, even when their symptoms are mild (2). Better understanding of transmission by children and adolescents in different settings is needed to refine public health guidance. Second, this investigation provides evidence of the benefit of physical distancing as a mitigation strategy to prevent SARS-CoV-2 transmission. None of the six family members who maintained outdoor physical distance without face masks during two visits to the family gathering developed symptoms; the four who were tested for SARS-CoV-2 had negative test results. Third, rapid antigen tests generally have lower sensitivity (84.0%�?7.6%) compared with RT-PCR testing; negative results should be confirmed with RT-PCR if used for persons with high pretest probability of infection, such as those with a known exposure (4). Fourth, regardless of negative test results, persons should self-quarantine for 14 days after a known exposure (5) or after travel when mandated by state, territorial, tribal, or local authorities (6). Finally, SARS-CoV-2 can spread efficiently during gatherings, especially with prolonged, close contact. Physical distancing, face mask use, and hand hygiene reduce transmission; gatherings should be avoided when physical distancing and face mask use are not possible (7).

AU  - Noah G. Schwartz, MD1, 2; Anne C. Moorman, MPH1; Anna Makaretz, ScM3; Karen T. Chang, PhD1,2; Victoria T. Chu, MD1,2; Christine M. Szablewski, DVM1,4; Anna R. Yousaf, MD1,2; Marie M. Brown, MPH4; Ailis Clyne, MD3; Amanda DellaGrotta, MPH3; Jan Drobeniuc, MD, PhD1; Jacqueline Korpics, MD5; Adam Muir, MSc6; Cherie Drenzek, DVM4; Utpala Bandy, MD3; Hannah L. Kirking, MD1; Jacqueline E. Tate, PhD1; Aron J. Hall, DVM1; Tatiana M. Lanzieri, MD1; Rebekah J. Stewart, MSN, MPH
C1  - 10/6/2020
DB  - Centers for Disease Control and Prevention
DP  - Centers for Disease Control and Prevention
IS  - early release
PY  - 2020
ST  - Adolescent with COVID-19 as the Source of an Outbreak at a 3-Week Family Gathering �?Four States, June–July 2020
T2  - MMWR Morbidity and Mortality Weekly Report
TI  - Adolescent with COVID-19 as the Source of an Outbreak at a 3-Week Family Gathering �?Four States, June–July 2020
UR  - http://www.cy118119.com/mmwr/volumes/69/wr/mm6940e2.htm?s_cid=mm6940e2_w
VL  - 69
ID  - 7788842
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19) pandemic is now a major global health threat. More than half a year have passed since the first discovery of severe acute respiratory syndrome coronavirus-2 (SARS-CoV2), no effective treatment has been established especially in intensive care unit. Inflammatory cytokine storm caused by SARS-CoV-2 infection has been reported to play a central role in COVID-19; therefore, treatments for suppressing cytokines, including extracorporeal treatments, are considered to be beneficial. However, until today the efficacy of removing cytokines by extracorporeal treatments in patients with COVID-19 is unclear. Herein, we report our experience with a 66-year-old male patient undergoing maintenance peritoneal dialysis who became critically ill with COVID-19 and underwent several extracorporeal treatment approaches including plasma exchange, direct hemoperfusion using a polymyxin B-immobilized fiber column and continuous hemodiafiltration. Though the patient developed acute respiratory distress syndrome (ARDS) repeatedly and subacute cerebral infarction and finally died for respiratory failure on day 30 after admission, these attempts appeared to dampen the cytokine storm based on the observed decline in serum IL-6 levels and were effective against ARDS and secondary haemophagocytic lymphohistiocytosis. This case suggests the significance of timely initiation of extracorporeal treatment approaches in critically ill patients with COVID-19.
AD  - Department of Nephrology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan.
Department of Nephrology, Faculty of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. yusuke@juntendo.ac.jp.
AN  - 33011959
AU  - Nihei, Y.
AU  - Nagasawa, H.
AU  - Fukao, Y.
AU  - Kihara, M.
AU  - Ueda, S.
AU  - Gohda, T.
AU  - Suzuki, Y.
C1  - 10/6/2020
C2  - PMC7532984
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s13730-020-00538-x
DP  - NLM
ET  - 2020/10/05
J2  - CEN case reports
KW  - Covid-19
Continuous renal replacement therapy
Cytokine storm
Plasma exchange
LA  - eng
N1  - 2192-4449
Nihei, Yoshihito
Nagasawa, Hajime
Fukao, Yusuke
Kihara, Masao
Ueda, Seiji
Gohda, Tomohito
Suzuki, Yusuke
Journal Article
CEN Case Rep. 2020 Oct 4:1-6. doi: 10.1007/s13730-020-00538-x.
PY  - 2020
SN  - 2192-4449
SP  - 1-6
ST  - Continuous extracorporeal treatments in a dialysis patient with COVID-19
T2  - CEN case reports
TI  - Continuous extracorporeal treatments in a dialysis patient with COVID-19
ID  - 7785638
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To describe the impact of the SARS-CoV-2 pandemic on the frequency of blood donation (BD) in a Latin American hospital and how the social isolation policy implemented during the pandemic jeopardizes the quality of postpartum hemorrhage (PPH) care due to shortages at blood banks (BB). METHODS: A retrospective, descriptive study was conducted, lasting for 31 months, including the start of the pandemic. Frequency of BD and the use of obstetric emergency services was observed. RESULTS: A direct relationship was observed between the pandemic and a decrease in BD. Although emergency obstetric visits decreased, the frequency of deliveries and cases of PPH remained unchanged. After applying strategies to promote voluntary BD, a very slight increase was observed in the frequency of BD, with a negative indicator persisting between donation and blood demand. CONCLUSION: The SARS-CoV-2 pandemic has led to shortages at BBs. In this context, typical measures to encourage an altruistic attitude toward donation have not had a significant impact. As causes of PPH continue, quality of care may be affected by the current situation at BBs. Governments and institutions must implement new strategies to motivate BD.
AD  - Fundaci�Qn Valle del Lili, Abnormally Invasive Placenta Clinic, Cali, Colombia.
Fundaci�Qn Valle del Lili, Blood Bank Department, Cali, Colombia.
Fundaci�Qn Valle del Lili, Clinical Research Center, Cali, Colombia.
Universidad Icesi, Department of Medicine, Cali, Colombia.
Fundaci�Qn Valle del Lili, Department of Anesthesiology, Cali, Colombia.
AN  - 33011971
AU  - Nieto-Calvache, A. J.
AU  - Quintero-Santacruz, M.
AU  - Macia-Mej�Ta, C.
AU  - L�Qpez-Gir�Qn, M. C.
AU  - Vergara-Galliadi, L. M.
AU  - Ariza, F.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1002/ijgo.13409
DP  - NLM
ET  - 2020/10/05
J2  - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
KW  - Blood donation
Covid-19
Postpartum hemorrhage
SARS-CoV-2
LA  - eng
N1  - 1879-3479
Nieto-Calvache, Albaro J
Quintero-Santacruz, Marcela
Macia-Mej�Ta, Carmenza
L�Qpez-Gir�Qn, Mar�Ta C
Vergara-Galliadi, Lina M
Ariza, Fredy
Journal Article
United States
Int J Gynaecol Obstet. 2020 Oct 4. doi: 10.1002/ijgo.13409.
PY  - 2020
SN  - 0020-7292
ST  - Dangerous shortage of blood banks as an indirect effect of SARS-CoV-2: An obstetrics perspective
T2  - International journal of gynaecology and obstetrics: official organ of International Federation of Gynaecology and Obstetrics
TI  - Dangerous shortage of blood banks as an indirect effect of SARS-CoV-2: An obstetrics perspective
ID  - 7785636
ER  - 

TY  - JOUR
AB  - Coronavirus disease-2019 (COVID-19) has so far caused hundreds of mortalities worldwide. Although respiratory symptoms are the main complication in COVID-19 patients, the disease is also associated with gastrointestinal problems, with diarrhea, nausea, and vomiting being primary COVID-19 symptoms. Thus, cancer and inflammatory bowel disease (IBD) management, stool viral tests, and virus exposure are major concerns in the context of COVID-19 epidemic. In patients with colorectal cancer and IBD, the colonic mucosa exhibits elevated angiotensin-converting enzyme 2 receptor levels, enhancing COVID-19 susceptibility. In some cases, positive viral stool tests may be the only indicator of infection at admission or after leaving quarantine. Without supplemental stool tests, the risk of undetected COVID-19 transmission is high. Moreover, viral exposure during the regular or emergency endoscopic examination should be avoided. We carefully discuss key gastrointestinal concerns with regard to COVID-19 and call for more attention to such problems. Copyright © The Author(s) 2020.
AD  - (Nie, Yang, Deng, Wang) Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan Province 410000, China
X.-Y. Wang, Department of Gastroenterology, The Third Xiangya Hospital of Central South University, No. 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province 410013, China. E-mail: wxy220011@163.com
AN  - 632998331
AU  - Nie, K.
AU  - Yang, Y. Y.
AU  - Deng, M. Z.
AU  - Wang, X. Y.
C1  - 10/6/2020
DA  - 26 Sep
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i18.3934
DP  - Ovid Technologies
IS  - 18
KW  - Colorectal cancer
covid-19
Diarrhea
Inflammatory bowel disease
SARS-CoV-2
Stool tests
adult
attention
cancer patient
clinical assessment
colon mucosa
complication
coronavirus disease 2019
epidemic
feces analysis
gastrointestinal symptom
gene expression
human
mortality
nausea and vomiting
protein expression
quarantine
review
angiotensin converting enzyme 2
endogenous compound
LA  - English
M3  - Review
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 3934-3941
ST  - Gastrointestinal insights during the COVID-19 epidemic
T2  - World Journal of Clinical Cases
TI  - Gastrointestinal insights during the COVID-19 epidemic
UR  - https://f6publishing.blob.core.windows.net/e8643eea-9706-49e1-9276-0f9f5271c837/WJCC-8-3934.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998331
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i18.3934&issn=2307-8960&isbn=&volume=8&issue=18&spage=3934&pages=3934-3941&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Gastrointestinal+insights+during+the+COVID-19+epidemic&aulast=Nie&pid=%3Cauthor%3ENie+K.%2CYang+Y.-Y.%2CDeng+M.-Z.%2CWang+X.-Y.%3C%2Fauthor%3E&%3CAN%3E632998331%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 8
ID  - 7782818
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) has affected patients across all age groups, with a wide range of illness severity from asymptomatic carriers to severe multi-organ dysfunction and death. Although early reports have shown that younger age groups experience less severe disease than older adults, our understanding of this phenomenon is in continuous evolution. Recently, a severe multisystem inflammatory syndrome in children (MIS-C), with active or recent COVID-19 infection, has been increasingly reported. Children with MIS-C may demonstrate signs and symptoms of Kawasaki disease, but also have some distinct differences. These children have more frequent and severe gastrointestinal symptoms and are more likely to present with a shock-like presentation. Moreover, they often present with cardiovascular involvement including myocardial dysfunction, valvulitis, and coronary artery dilation or aneurysms. Here, we present a review of the literature and summary of our current understanding of cardiovascular involvement in children with COVID-19 or MIS-C and identifying the role of a pediatric cardiologist in caring for these patients.
AD  - Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Division of Pediatric Cardiology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
Division of Pediatric Cardiology, Department of Pediatrics, Columbia University College of Physicians and Surgeons, Morgan Stanley Children's Hospital of New York, New York, USA.
Pediatric Cardiology, Cohen Children's Medical Center, New Hyde Park, NY, USA.
Department of Cardiology, Hospital Sant Joan de Deu, Barcelona, Spain.
Paediatric Cardiology Services, Royal Brompton and Harefield Hospitals Trust, National Heart and Lung Institute, Imperial College, London, UK.
Section of Pediatric Cardiothoracic Surgery, Washington University School of Medicine, St Louis Children's Hospital, St Louis, MO, USA.
Pediatric Cardiology, Rainbow Babies and Children's Hospital, Case Western Reserve University, School of Medicine, Cleveland, OH, USA.
Cardiology Care for Children, 1834 Oregon Pike, Ste 20, Lancaster, PA, 17601, USA. dchowdhury@cardiologylancaster.com.
AN  - 33015722
AU  - Niaz, T.
AU  - Hope, K.
AU  - Fremed, M.
AU  - Misra, N.
AU  - Altman, C.
AU  - Glickstein, J.
AU  - Sanchez-de-Toledo, J.
AU  - Fraisse, A.
AU  - Miller, J.
AU  - Snyder, C.
AU  - Johnson, J. N.
AU  - Chowdhury, D.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s00246-020-02476-y
DP  - NLM
ET  - 2020/10/06
J2  - Pediatric cardiology
KW  - Covid-19
Cardiovascular
Mis-c
Pediatric
LA  - eng
N1  - 1432-1971
Niaz, Talha
Hope, Kyle
Fremed, Michael
Misra, Nilanjana
Altman, Carrie
Glickstein, Julie
Sanchez-de-Toledo, Joan
Fraisse, Alain
Miller, Jacob
Snyder, Christopher
Johnson, Jonathan N
Chowdhury, Devyani
Journal Article
Review
United States
Pediatr Cardiol. 2020 Oct 4. doi: 10.1007/s00246-020-02476-y.
PY  - 2020
SN  - 0172-0643
ST  - Role of a Pediatric Cardiologist in the COVID-19 Pandemic
T2  - Pediatric cardiology
TI  - Role of a Pediatric Cardiologist in the COVID-19 Pandemic
ID  - 7785255
ER  - 

TY  - JOUR
AB  - PURPOSE: The coronavirus disease 2019 (COVID-19) pandemic has had a global impact, and Singapore has seen 33,000 confirmed cases. Patients with cancer, their caregivers, and health care workers (HCWs) need to balance the challenges associated with COVID-19 while ensuring that cancer care is not compromised. This study aimed to evaluate the psychological effect of COVID-19 on these groups and the prevalence of burnout among HCWs. METHODS: A cross-sectional survey of patients, caregivers, and HCWs at the National Cancer Centre Singapore was performed over 17 days during the lockdown. The Generalized Anxiety Disorder-7 and Maslach Burnout Inventory were used to assess for anxiety and burnout, respectively. Self-reported fears related to COVID-19 were collected. RESULTS: A total of 624 patients, 408 caregivers, and 421 HCWs participated in the study, with a response rate of 84%, 88%, and 92% respectively. Sixty-six percent of patients, 72.8% of caregivers, and 41.6% of HCWs reported a high level of fear from COVID-19. The top concern of patients was the wide community spread of COVID-19. Caregivers were primarily worried about patients dying alone. HCWs were most worried about the relatively mild symptoms of COVID-19. The prevalence of anxiety was 19.1%, 22.5%, and 14.0% for patients, caregivers, and HCWs, respectively. Patients who were nongraduates and married, and caregivers who were married were more anxious. The prevalence of burnout in HCWs was 43.5%, with more anxious and fearful HCWs reporting higher burnout rates. CONCLUSION: Fears and anxiety related to COVID-19 are high. Burnout among HCWs is similar to rates reported prepandemic. An individualized approach to target the specific fears of each group will be crucial to maintain the well-being of these vulnerable groups and prevent burnout of HCWs.
AD  - Division of Medical Oncology, National Cancer Centre, Singapore.
Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore.
Oncology Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Division of Radiation Oncology, National Cancer Centre, Singapore.
Department of Pharmacy, National Cancer Centre, Singapore.
Department of Nursing, National Cancer Centre, Singapore.
Division of Oncological Imaging, National Cancer Centre, Singapore.
AN  - 33017179
AU  - Ng, K. Y. Y.
AU  - Zhou, S.
AU  - Tan, S. H.
AU  - Ishak, N. D. B.
AU  - Goh, Z. Z. S.
AU  - Chua, Z. Y.
AU  - Chia, J. M. X.
AU  - Chew, E. L.
AU  - Shwe, T.
AU  - Mok, J. K. Y.
AU  - Leong, S. S.
AU  - Lo, J. S. Y.
AU  - Ang, Z. L. T.
AU  - Leow, J. L.
AU  - Lam, C. W. J.
AU  - Kwek, J. W.
AU  - Dent, R.
AU  - Tuan, J.
AU  - Lim, S. T.
AU  - Hwang, W. Y. K.
AU  - Griva, K.
AU  - Ngeow, J.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1200/go.20.00374
DP  - NLM
ET  - 2020/10/06
J2  - JCO global oncology
LA  - eng
N1  - 2687-8941
Ng, Kennedy Yao Yi
Orcid: 0000-0001-6630-3803
Zhou, Siqin
Tan, Sze Huey
Orcid: 0000-0002-3089-7379
Ishak, Nur Diana Binte
Goh, Zack Zhong Sheng
Chua, Zi Yang
Chia, Jace Ming Xuan
Chew, Ee Ling
Shwe, Than
Mok, Jacklyn Kah Yeen
Leong, Shen Si
Lo, Joanne Si Ying
Ang, Zoe Li Ting
Leow, Jo Lene
Lam, Chanel Wei Jie
Kwek, Jin Wei
Orcid: 0000-0002-3081-5767
Dent, Rebecca
Tuan, Jeffrey
Lim, Soon Thye
Orcid: 0000-0002-0366-5505
Hwang, William Ying Khee
Orcid: 0000-0003-0143-6263
Griva, Konstadina
Orcid: 0000-0001-8173-5663
Ngeow, Joanne
Orcid: 0000-0003-1558-3627
Journal Article
United States
JCO Glob Oncol. 2020 Oct;6:1494-1509. doi: 10.1200/GO.20.00374.
PY  - 2020
SN  - 2687-8941
SP  - 1494-1509
ST  - Understanding the Psychological Impact of COVID-19 Pandemic on Patients With Cancer, Their Caregivers, and Health Care Workers in Singapore
T2  - JCO global oncology
TI  - Understanding the Psychological Impact of COVID-19 Pandemic on Patients With Cancer, Their Caregivers, and Health Care Workers in Singapore
VL  - 6
ID  - 7785156
ER  - 

TY  - JOUR
AB  - OBJECTIVES: The aim of this study was to estimate delay-adjusted case fatality rates (CFRs) for COVID-19 in South Korea and evaluate how these estimates have evolved over time throughout the epidemic. METHODS: Data from the Korea Centers for Disease Control and Prevention (KCDC) were used to estimate age- and sex-specific CFRs for COVID-19 in South Korea up until the 12th June 2020. We applied statistical methods previously developed to adjust for the delay between diagnosis and death and presented both delay-adjusted and crude (unadjusted) CFRs throughout the epidemic. RESULTS: The overall estimated delay-adjusted CFR was 2.39% (3.05% for males and 1.92% for females). Within each age strata where deaths were reported, we found males had significantly higher CFRs than females. The estimated CFRs increased substantially from age 60 years in males and from 70 years in females. We found that both the delay-adjusted CFRs and crude CFRs evolved substantially, particularly early in the epidemic, converging only from mid-April 2020. CONCLUSIONS: The CFRs for South Korea provide an estimate of mortality risk in a setting where case ascertainment is likely to be more complete. The evolution in CFRs throughout the epidemic highlights the need for caution when interpreting CFRs calculated at a given time point.
AD  - School of Public Health and Community Medicine, University of NSW, Sydney, NSW, Australia. Electronic address: a.newall@unsw.edu.au.
School of Public Health and Community Medicine, University of NSW, Sydney, NSW, Australia. Electronic address: robertneil.leong@unsw.edu.au.
School of Public Health and Community Medicine, University of NSW, Sydney, NSW, Australia. Electronic address: a.nazareno@unsw.edu.au.
School of Public Health and Community Medicine, University of NSW, Sydney, NSW, Australia. Electronic address: david.muscatello@unsw.edu.au.
School of Public Health and Community Medicine, University of NSW, Sydney, NSW, Australia. Electronic address: james.wood@unsw.edu.au.
Department of Infectious Diseases, Guro Hospital, Korea University College of Medicine, Seoul, South Korea. Electronic address: wjkim@korea.ac.kr.
AN  - 33011281
AU  - Newall, A. T.
AU  - Leong, R. N. F.
AU  - Nazareno, A.
AU  - Muscatello, D. J.
AU  - Wood, J. G.
AU  - Kim, W. J.
C1  - 10/6/2020
C2  - PMC7529598
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.ijid.2020.09.1478
DP  - NLM
ET  - 2020/10/05
J2  - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
KW  - Covid-19
Case-fatality rate
Death
Mortality
SARS-CoV-2
LA  - eng
N1  - 1878-3511
Newall, A T
Leong, R N F
Nazareno, A
Muscatello, D J
Wood, J G
Kim, W J
Journal Article
Int J Infect Dis. 2020 Oct 1:S1201-9712(20)32194-9. doi: 10.1016/j.ijid.2020.09.1478.
PY  - 2020
SN  - 1201-9712 (Print)
1201-9712
ST  - Delay-adjusted age- and sex-specific case fatality rates for COVID-19 in South Korea: evolution in the estimated risk of mortality throughout the epidemic
T2  - International journal of infectious diseases : IJID : official publication of International Society for Infectious Diseases
TI  - Delay-adjusted age- and sex-specific case fatality rates for COVID-19 in South Korea: evolution in the estimated risk of mortality throughout the epidemic
ID  - 7785683
ER  - 

TY  - JOUR
AD  - J.-Y. Nau J.-Y. Nau
AN  - 2007813267
AU  - Nau, J. Y.
C1  - 10/6/2020
DA  - 26 Aug
DB  - Embase
DP  - Ovid Technologies
IS  - 703
KW  - Coronavirinae
immune system
nonhuman
reproduction
short survey
LA  - French
M3  - Short Survey
PY  - 2020
SN  - 1660-9379
SP  - 1530-1531
ST  - Miscellanea about coronaviruses and reproduction, viruses and immune systems. [French]
T2  - Revue Medicale Suisse
TI  - Miscellanea about coronaviruses and reproduction, viruses and immune systems. [French]
TT  - Miscellanees coronavirales et procreatives, virales et immunitaires.
UR  - https://www.revmed.ch/RMS/2020/RMS-N-703/Miscellanees-coronavirales-et-procreatives-virales-et-immunitaires
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007813267
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=&issn=1660-9379&isbn=&volume=16&issue=703&spage=1530&pages=1530-1531&date=2020&title=Revue+Medicale+Suisse&atitle=Miscellanees+coronavirales+et+procreatives%2C+virales+et+immunitaires&aulast=Nau&pid=%3Cauthor%3ENau+J.-Y.%3C%2Fauthor%3E&%3CAN%3E2007813267%3C%2FAN%3E&%3CDT%3EShort+Survey%3C%2FDT%3E
VL  - 16
ID  - 7782848
ER  - 

TY  - JOUR
AB  - OBJECTIVE: In physiological conditions, arterial blood lactate concentration is equal to or lower than central venous blood lactate concentration. A reversal in this rate (i.e., higher lactate concentration in central venous blood), which could reflect a derangement in the mitochondrial metabolism of lung cells induced by inflammation, has been previously reported in patients with ARDS but has been never explored in COVID-19 patients. The aim of this study was to explore if the COVID-19-induced lung cell damage was mirrored by an arterial lactatemia higher than the central venous one; then if the administration of anti-inflammatory therapy (i.e., canakinumab 300 mg subcutaneous) could normalize such abnormal lactate a-cv difference. METHODS: A prospective cohort study was conducted, started on March 25, 2020, for a duration of 10 days, enrolling 21 patients affected by severe COVID-19 pneumonia undergoing mechanical ventilation consecutively admitted to the ICU of the Rimini Hospital, Italy. Arterial and central venous blood samples were contemporarily collected to calculate the difference between arterial and central venous lactate (Delta a-cv lactate) concentrations within 24 h from tracheal intubation (T (0)) and 24 hours after canakinumab administration (T (1)). RESULTS: At T (0), 19 of 21 (90.5%) patients showed a pathologic Delta a-cv lactate (median 0.15 mmol/L; IQR 0.07-0.25). In the 13 patients undergoing canakinumab administration, at T (1), Delta a-cv lactate decreased in 92.3% of cases, the decrease being statistically significant (T (0): median 0.24, IQR 0.09-0.31 mmol/L; T (1): median -0.01, IQR -0.08-0.04 mmol/L; p=0.002). CONCLUSION: A reversed Delta a-cv lactate might be interpreted as one of the effects of COVID-19-related cytokine storm, which could reflect a derangement in the mitochondrial metabolism of lung cells induced by severe inflammation or other uncoupling mediators. In addition, Delta a-cv lactate decrease might also reflect the anti-inflammatory activity of canakinumab. Our preliminary findings need to be confirmed by larger outcome studies.
AD  - Dept. of Anaesthesia and Intensive Care, Infermi Hospital, Viale Settembrini 2, 47921 Rimini, Italy.
Clinical Dept. of Medical, Surgical and Health Sciences, University of Trieste, Strada Di Fiume 447, 34149 Trieste, Italy.
Dept of Emergency Medicine, AORN San Pio, Via Pacevecchia 53, 82100 Benevento, Italy.
Emergency Dept San Paolo Hospital, Via Terracina, 80125 Naples, Italy.
AN  - 33014462
AU  - Nardi, G.
AU  - Sanson, G.
AU  - Tassinari, L.
AU  - Guiotto, G.
AU  - Potalivo, A.
AU  - Montomoli, J.
AU  - Schiraldi, F.
C1  - 10/6/2020
C2  - PMC7519437
DB  - PubMed
DO  - 10.1155/2020/4743904
DP  - NLM
ET  - 2020/10/06
J2  - Critical care research and practice
LA  - eng
N1  - 2090-1313
Nardi, Giuseppe
Orcid: 0000-0002-1866-568x
Sanson, Gianfranco
Orcid: 0000-0001-8319-635x
Tassinari, Lucia
Guiotto, Giovanna
Potalivo, Antonella
Montomoli, Jonathan
Schiraldi, Fernando
Orcid: 0000-0002-1985-7616
Journal Article
Crit Care Res Pract. 2020 Sep 25;2020:4743904. doi: 10.1155/2020/4743904. eCollection 2020.
PY  - 2020
SN  - 2090-1305 (Print)
2090-1305
SP  - 4743904
ST  - Lactate Arterial-Central Venous Gradient among COVID-19 Patients in ICU: A Potential Tool in the Clinical Practice
T2  - Critical care research and practice
TI  - Lactate Arterial-Central Venous Gradient among COVID-19 Patients in ICU: A Potential Tool in the Clinical Practice
VL  - 2020
ID  - 7785396
ER  - 

TY  - JOUR
AD  - Adventist Medical Center, Hanford, CA, USA.
Ashland Bellefonte Cancer Center, Ashland, KY, USA.
Phoebe Putney Memorial Hospital, Albany, GA, USA.
Medical College of Georgia, Augusta, GA, USA.
Interfaith Medical Center, Brooklyn, NY, USA.
AN  - 33019825
AU  - Naramala, S.
AU  - Konala, V. M.
AU  - Adapa, S.
AU  - Chenna, A.
AU  - Garlapati, P. R.
AU  - Gayam, V.
C1  - 10/6/2020
DA  - Jan-Dec
DB  - PubMed
DO  - 10.1177/2324709620963611
DP  - NLM
ET  - 2020/10/07
J2  - Journal of investigative medicine high impact case reports
LA  - eng
N1  - 2324-7096
Naramala, Srikanth
Orcid: 0000-0003-1238-856x
Konala, Venu Madhav
Orcid: 0000-0003-1953-8815
Adapa, Sreedhar
Orcid: 0000-0001-5608-5654
Chenna, Avantika
Garlapati, Pavani Reddy
Gayam, Vijay
Orcid: 0000-0001-5194-9134
Letter
United States
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620963611. doi: 10.1177/2324709620963611.
PY  - 2020
SN  - 2324-7096
SP  - 2324709620963611
ST  - Response to Letter Regarding "A Case Series of Patients Coinfected With Influenza and COVID-19"
T2  - Journal of investigative medicine high impact case reports
TI  - Response to Letter Regarding "A Case Series of Patients Coinfected With Influenza and COVID-19"
VL  - 8
ID  - 7785086
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has hit hard on the world economy and global health. Where most businesses are completely closed following governments restrictions, the food sector across the supply chain must remain operational in order to feed the nations. In such a challenging time, keeping the workers healthy and safe is critical while maintaining a high level of food safety and consumer confidence. Against a backdrop of heightened uncertainty, up-to-date and reliable information is more important than ever, both for regulators and this sector. This literature review aims at assembling all current knowledge about COVID-19 and its impact on the food industry. It is an exhaustive compilation of relevant public information and guidance published by the World Health Organization (WHO), and collected from 11 governmental and 10 non-governmental sources as well as 25 peer-reviewed articles published in scientific journals since the beginning of the crisis till June 5th, 2020. This paper could be of assistance to educators, researchers, and policy makers. It could also serve as an assessment tool to ensure business continuity and to determine the level of food industry readiness providing reassurance to all stakeholders during these unprecedented times.
AD  - Afnor Groupe, Nohra Bldg, Tahwita Highway, Furn El Chebbak. P.O.Box: 16-5806, Beirut, Lebanon.
Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, P.O.Box: 72, Zouk Mikael, Lebanon.
AN  - 33013004
AU  - Nakat, Z.
AU  - Bou-Mitri, C.
C1  - 10/6/2020
C2  - PMC7523550
DA  - Mar
DB  - PubMed
DO  - 10.1016/j.foodcont.2020.107661
DP  - NLM
ET  - 2020/10/06
J2  - Food control
KW  - Covid-19
Food industry
Food safety
Guidance
Occupational safety and health
Risk assessment.
cGMP
for providing expert advice and intervention for the food industry on the current
COVID-19 Pandemic. No other potential conflict of interest relevant to this paper
was reported.
LA  - eng
N1  - 0956-7135
Nakat, Zeina
Bou-Mitri, Christelle
Journal Article
Food Control. 2021 Mar;121:107661. doi: 10.1016/j.foodcont.2020.107661. Epub 2020 Sep 29.
PY  - 2021
SN  - 0956-7135 (Print)
0956-7135
SP  - 107661
ST  - COVID-19 and the food industry: Readiness assessment
T2  - Food control
TI  - COVID-19 and the food industry: Readiness assessment
VL  - 121
ID  - 7785513
ER  - 

TY  - JOUR
AN  - 33019956
AU  - Myers, K. A.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1017/cjn.2020.220
DP  - NLM
ET  - 2020/10/07
J2  - The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
LA  - eng
N1  - Myers, Kenneth A
Orcid: 0000-0001-7831-4593
Journal Article
England
Can J Neurol Sci. 2020 Oct 6:1-6. doi: 10.1017/cjn.2020.220.
PY  - 2020
SN  - 0317-1671 (Print)
0317-1671
SP  - 1-6
ST  - Response to Canadian Neurophysiology Laboratory COVID-19 Practice Guidelines
T2  - Canadian journal of neurological sciences Le journal canadien des sciences neurologiques
TI  - Response to Canadian Neurophysiology Laboratory COVID-19 Practice Guidelines
ID  - 7785068
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Recent anecdotal reports and cadaveric simulations have described aerosol generation during endonasal instrumentation, highlighting a possible risk for transmission of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during endoscopic endonasal instrumentation. This study aims to provide a greater understanding of particle generation and exposure risk during endoscopic endonasal instrumentation. STUDY DESIGN: Prospective quantification of aerosol generation during office-based nasal endoscopy procedures. METHODS: Using an optical particle sizer, airborne particles concentrations 0.3 to 10 microns in diameter, were measured during 30 nasal endoscopies in the clinic setting. Measurements were taken at time points throughout diagnostic and debridement endoscopies and compared to preprocedure and empty room particle concentrations. RESULTS: No significant change in airborne particle concentrations was measured during diagnostic nasal endoscopies in patients without the need for debridement. However, significant increases in mean particle concentration compared to preprocedure levels were measured during cold instrumentation at 2,462 particles/foot(3) (95% CI 837 to 4,088; P =�?005) and during suction use at 2,973 particle/foot(3) (95% CI 1,419 to 4,529; P =�?001). In total, 99.2% of all measured particles were �? μm in diameter. CONCLUSION: When measured with an optical particle sizer, diagnostic nasal endoscopy with a rigid endoscope is not associated with increased particle aerosolization in patient for whom sinonasal debridement is not needed. In patients needing sinonasal debridement, endonasal cold and suction instrumentation were associated with increased particle aerosolization, with a trend observed during endoscope use prior to tissue manipulation. Endonasal debridement may potentially pose a higher risk for aerosolization and SARS-CoV-2 transmission. Appropriate personal protective equipment use and patient screening are recommended for all office-based endonasal procedures. LEVEL OF EVIDENCE: 3 Laryngoscope, 2020.
AD  - Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.
AN  - 33017067
AU  - Murr, A. T.
AU  - Lenze, N. R.
AU  - Gelpi, M. W.
AU  - Brown, W. C.
AU  - Ebert, C. S., Jr.
AU  - Senior, B. A.
AU  - Thorp, B. D.
AU  - Kimple, A. J.
AU  - Zanation, A. M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/lary.29122
DP  - NLM
ET  - 2020/10/06
J2  - The Laryngoscope
KW  - Covid-19
aerosol-generating procedures
droplet quantification
nasal endoscopy
optical particle sizer
LA  - eng
N1  - 1531-4995
Murr, Alexander T
Orcid: 0000-0003-1102-9477
Lenze, Nicholas R
Orcid: 0000-0002-2126-6663
Gelpi, Mark W
Brown, William C
Ebert, Charles S Jr
Senior, Brent A
Thorp, Brian D
Kimple, Adam J
Orcid: 0000-0003-1670-8401
Zanation, Adam M
Distinguished Medical Scholars/Howard Holderness Distinguished Medical Scholars program/
KL2TR002490/NH/NIH HHS/United States
Pillsbury Medical Student Research Grant/Pillsbury Medical Student Research Fellowship/
Journal Article
United States
Laryngoscope. 2020 Oct 5. doi: 10.1002/lary.29122.
PY  - 2020
SN  - 0023-852x
ST  - Quantification of Aerosol Concentrations During Endonasal Instrumentation in the Clinic Setting
T2  - Laryngoscope
TI  - Quantification of Aerosol Concentrations During Endonasal Instrumentation in the Clinic Setting
ID  - 7785165
ER  - 

TY  - JOUR
AB  - BACKGROUND: Recent indirect evidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission during endoscopic endonasal procedures has highlighted the dearth of knowledge surrounding aerosol generation with these procedures. As we adapt to function in the era of Coronavirus Disease 2019 (COVID-19) a better understanding of how surgical techniques generate potentially infectious aerosolized particles will enhance the safety of operating room (OR) staff and learners. OBJECTIVE: To provide greater understanding of possible SARS-CoV-2 exposure risk during endonasal surgeries by quantifying increases in airborne particle concentrations during endoscopic sinonasal surgery. METHODS: Aerosol concentrations were measured during live-patient endoscopic endonasal surgeries in ORs with an optical particle sizer. Measurements were taken throughout the procedure at six time points: 1) before patient entered the OR, 2) before pre-incision timeout during OR setup, 3) during cold instrumentation with suction, 4) during microdebrider use, 5) during drill use and, 6) at the end of the case prior to extubation. Measurements were taken at three different OR position: surgeon, circulating nurse, and anesthesia provider. RESULTS: Significant increases in airborne particle concentration were measured at the surgeon position with both the microdebrider (p�?�?.001) and drill (p�?�?.001), but not for cold instrumentation with suction (p�?�?.340). Particle concentration did not significantly increase at the anesthesia position or the circulator position with any form of instrumentation. Overall, the surgeon position had a mean increase in particle concentration of 2445 particles/ft3 (95% CI 881 to 3955; p�?�?.001) during drill use and 1825 particles/ft3 (95% CI 641 to 3009; p�?�?.001) during microdebrider use. CONCLUSION: Drilling and microdebrider use during endonasal surgery in a standard operating room is associated with a significant increase in airborne particle concentrations. Fortunately, this increase in aerosol concentration is localized to the area of the operating surgeon, with no detectable increase in aerosol particles at other OR positions.
AD  - Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
AN  - 33012174
AU  - Murr, A.
AU  - Lenze, N. R.
AU  - Brown, W. C.
AU  - Gelpi, M. W.
AU  - Ebert, C. S., Jr.
AU  - Senior, B. A.
AU  - Thorp, B. D.
AU  - Zanation, A. M.
AU  - Kimple, A. J.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/1945892420962335
DP  - NLM
ET  - 2020/10/06
J2  - American journal of rhinology & allergy
KW  - Covid-19
SARS-CoV-2
aerosolization
airborne particles
endoscopic sinus surgery
LA  - eng
N1  - 1945-8932
Murr, Alex
Orcid: 0000-0003-1102-9477
Lenze, Nicholas R
Brown, William Colby
Orcid: 0000-0002-5305-1210
Gelpi, Mark W
Ebert, Charles S Jr
Senior, Brent A
Thorp, Brian D
Zanation, Adam M
Kimple, Adam J
Journal Article
United States
Am J Rhinol Allergy. 2020 Oct 4:1945892420962335. doi: 10.1177/1945892420962335.
PY  - 2020
SN  - 1945-8932
SP  - 1945892420962335
ST  - Quantification of Aerosol Particle Concentrations During Endoscopic Sinonasal Surgery in the Operating Room
T2  - American journal of rhinology & allergy
TI  - Quantification of Aerosol Particle Concentrations During Endoscopic Sinonasal Surgery in the Operating Room
ID  - 7785614
ER  - 

TY  - JOUR
AB  - There are many barriers to fieldwork including cost, time, and physical ability Unfortunately, these barriers disproportionately affect minority communities and create a disparity in access to fieldwork in the natural sciences Travel restrictions, concerns about our carbon footprint, and the global lockdown have extended this barrier to fieldwork across the community and led to increased anxiety about gaps in productivity, especially among graduate students and early-career researchers In this paper, we discuss agent-based modeling as an open-source, accessible, and inclusive resource to substitute for lost fieldwork during COVID-19 and for future scenarios of travel restrictions such as climate change and economic downturn We describe the benefits of Agent-Based models as a teaching and training resource for students across education levels We discuss how and why educators and research scientists can implement them with examples from the literature on how agent-based models can be applied broadly across life science research We aim to amplify awareness and adoption of this technique to broaden the diversity and size of the agent-based modeling community in ecology and evolutionary research Finally, we discuss the challenges facing agent-based modeling and discuss how quantitative ecology can work in tandem with traditional field ecology to improve both methods
AU  - Murphy, Kilian J.
AU  - Ciuti, Simone
AU  - Kane, Adam
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - An introduction to agent-based models as an accessible surrogate to field-based research and teaching
T2  - Ecology and Evolution
TI  - An introduction to agent-based models as an accessible surrogate to field-based research and teaching
UR  - https://doi.org/10.1002/ece3.6848
ID  - 7788141
ER  - 

TY  - JOUR
AU  - Murphy, David
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - David Murphy, Chair of the Covid-19
T2  - Psychologist
TI  - David Murphy, Chair of the Covid-19
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812945
ID  - 7788115
ER  - 

TY  - JOUR
AB  - We adopt a holistic-micro, meso, macro-approach to health leadership ethics to examine how low- and middle-income countries have responded to the COVID-19 pandemic. Healthcare delivery happens within complex settings in low- and middle-income countries and high-income countries. These settings are riddled with systemic political and economic challenges which, in some instances, make it difficult for health leaders to be ethical. These challenges, however, are not unique to low- and middle-income countries. Globally, countries can learn from ethical health leadership missteps that occurred during low- and middle-income countries' responses to COVID-19. We discuss the implications of problematic ethics in health leadership on managing pandemics in low- and middle-income countries, using Zimbabwe as an example. We offer suggestions on what can be done to improve ethical health leadership in response to future health crises in both high-income and low- and middle-income nations.
AD  - Research Promotion and Initiatives, 120458Smith School of Business, Queen's University, Kingston, Ontario, Canada.
Global Health, Department of Medical Oncology, Queen's University, Kingston Ontario, Canada.
AN  - 33016129
AU  - Munezhi, M.
AU  - Hammad, N.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/0840470420961913
DP  - NLM
ET  - 2020/10/06
J2  - Healthcare management forum
LA  - eng
N1  - Munezhi, Martha
Hammad, Nazik
Journal Article
United States
Healthc Manage Forum. 2020 Oct 5:840470420961913. doi: 10.1177/0840470420961913.
PY  - 2020
SN  - 0840-4704 (Print)
0840-4704
SP  - 840470420961913
ST  - Ethical health leadership: Lessons from low- and middle-income countries during COVID-19
T2  - Healthcare management forum
TI  - Ethical health leadership: Lessons from low- and middle-income countries during COVID-19
ID  - 7785221
ER  - 

TY  - JOUR
AB  - OBJECTIVES: Following the outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus and the subsequent global spread of the 2019 novel coronavirus disease (COVID-19), health systems and the populations who use them have faced unprecedented challenges. We aimed to measure the impact of COVID-19 on the uptake of hospital-based care at a national level. DESIGN: The study period (weeks ending 5 January to 28 June 2020) encompassed the pandemic announcement by the World Health Organization and the initiation of the UK lockdown. We undertook an interrupted time-series analysis to evaluate the impact of these events on hospital services at a national level and across demographics, clinical specialties and National Health Service Health Boards. SETTING: Scotland, UK. PARTICIPANTS: Patients receiving hospital care from National Health Service Scotland. MAIN OUTCOME MEASURES: Accident and emergency (A&E) attendances, and emergency and planned hospital admissions measured using the relative change of weekly counts in 2020 to the averaged counts for equivalent weeks in 2018 and 2019. RESULTS: Before the pandemic announcement, the uptake of hospital care was largely consistent with historical levels. This was followed by sharp drops in all outcomes until UK lockdown, where activity began to steadily increase. This time-period saw an average reduction of -40.7% (95% confidence interval [CI]: -47.7 to -33.7) in A&E attendances, -25.8% (95% CI: -31.1 to -20.4) in emergency hospital admissions and -60.9% (95% CI: -66.1 to -55.7) in planned hospital admissions, in comparison to the 2018-2019 averages. All subgroup trends were broadly consistent within outcomes, but with notable variations across age groups, specialties and geography. CONCLUSIONS: COVID-19 has had a profoundly disruptive impact on hospital-based care across National Health Service Scotland. This has likely led to an adverse effect on non-COVID-19-related illnesses, increasing the possibility of potentially avoidable morbidity and mortality. Further research is required to elucidate these impacts.
AD  - Usher Institute, University of Edinburgh, Edinburgh EH8 9YL, UK.
National Health Service Scotland, Public Health Scotland, Glasgow G2 6QE and Edinburgh EH12 9EB, UK.
Centre for Brain Sciences, Centre for Population Health, University of Edinburgh, Edinburgh EH8 9YL, UK.
School of Health, Wellington Faculty of Health, Victoria University of Wellington, Wellington PO Box 600, Wellington 6140, New Zealand.
School of Medicine, University of St Andrews, St Andrews KY16 9AJ, UK.
Centre of Academic Primary Care, University of Aberdeen, Aberdeen AB24 3FX, UK.
Department of Mathematics and Statistics, University of Strathclyde, Glasgow G1 1XQ, UK.
AN  - 33012218
AU  - Mulholland, R. H.
AU  - Wood, R.
AU  - Stagg, H. R.
AU  - Fischbacher, C.
AU  - Villacampa, J.
AU  - Simpson, C. R.
AU  - Vasileiou, E.
AU  - McCowan, C.
AU  - Stock, S. J.
AU  - Docherty, A. B.
AU  - Ritchie, L. D.
AU  - Agrawal, U.
AU  - Robertson, C.
AU  - Murray, J. L.
AU  - MacKenzie, F.
AU  - Sheikh, A.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/0141076820962447
DP  - NLM
ET  - 2020/10/06
J2  - Journal of the Royal Society of Medicine
KW  - A&E attendances
Covid-19
SARS-CoV-2
hospital admissions
secondary care
uptake
LA  - eng
N1  - 1758-1095
Mulholland, Rachel H
Orcid: 0000-0003-1020-3373
Wood, Rachael
Orcid: 0000-0003-4453-623x
Stagg, Helen R
Fischbacher, Colin
Villacampa, Jaime
Simpson, Colin R
Vasileiou, Eleftheria
McCowan, Colin
Stock, Sarah J
Docherty, Annemarie B
Orcid: 0000-0001-8277-420x
Ritchie, Lewis D
Agrawal, Utkarsh
Robertson, Chris
Murray, Josephine Lk
MacKenzie, Fiona
Sheikh, Aziz
Journal Article
England
J R Soc Med. 2020 Oct 4:141076820962447. doi: 10.1177/0141076820962447.
PY  - 2020
SN  - 0141-0768
SP  - 141076820962447
ST  - Impact of COVID-19 on accident and emergency attendances and emergency and planned hospital admissions in Scotland: an interrupted time-series analysis
T2  - Journal of Royal Society of Medicine
TI  - Impact of COVID-19 on accident and emergency attendances and emergency and planned hospital admissions in Scotland: an interrupted time-series analysis
ID  - 7785611
ER  - 

TY  - JOUR
AU  - Moyses, Valerie
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Make covid-19 vaccines mandatory to go overseas?
T2  - New Scientist
TI  - Make covid-19 vaccines mandatory to go overseas?
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812946
ID  - 7788114
ER  - 

TY  - JOUR
AB  - INTRODUCTION: The celebrated diarist Samuel Pepys kept a detailed diary of exceptional candour throughout the years of The Great Plague of 1665, in which he recorded his own observations as well as the reactions of society and the medical profession to this unprecedented event. In this paper we examine his diaries at the time of the plague, as well as in the proceeding years and consider how the experiences of Pepys are similar to our own experiences of the 2020 Coronavirus Epidemic. METHOD: We examined the entire diaries of Samuel Pepys from 1664 to 1670, as well as supplementary source material, looking for all references to The Great Plague.Results and Conclusion: Though written over 350 years ago the diaries paint a very co-orientated response of society to The Plague. Accurate official statistics were available weekly, isolation was imposed and the government made provision for 'pest houses' to be set up. Pepys is grateful to the doctors who remain in London but critical of the majority who flee the city. Pepys's own reactions, which progress from fear of contracting the disease to fear for his business interests, mirror today's reaction to The 2020 Coronavirus Epidemic.
AD  - St Mary's Hospital, London, UK.
4617Queen Mary University of London, UK.
AN  - 33016177
AU  - Mosli-Lynch, C.
AU  - O'Shaughnessy, N.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/0967772020948781
DP  - NLM
ET  - 2020/10/06
J2  - Journal of medical biography
KW  - Covid-19
Pepys
Samuel Pepys
coronavirus
plague
LA  - eng
N1  - 1758-1087
Mosli-Lynch, Conor
Orcid: 0000-0002-1008-3597
O'Shaughnessy, Nicholas
Journal Article
England
J Med Biogr. 2020 Oct 4:967772020948781. doi: 10.1177/0967772020948781.
PY  - 2020
SN  - 0967-7720
SP  - 967772020948781
ST  - Pepys's plague: How the reaction of the individual, society and the medical profession to the Great Plague of 1665 is similar to our experience of Covid-19
T2  - Journal of medical biography
TI  - Pepys's plague: How the reaction of the individual, society and the medical profession to the Great Plague of 1665 is similar to our experience of Covid-19
ID  - 7785214
ER  - 

TY  - JOUR
AB  - Previous studies link obesity and individual components of metabolic syndrome to increased hospitalisations and death rates of patients with COVID-19. Here, in two overlapping samples of over 1,000 individuals from the UK Biobank we investigate whether metabolic syndrome, and its constituent components, increased waist circumference, dyslipidaemia, hypertension, diabetes, and systemic inflammation, are related to increased COVID-19 infection and mortality rates. Using logistic regression and controlling for confounding variables such as socioeconomic status, age, sex or ethnicity, we find that individuals with pre-existing metabolic syndrome (measured on average eleven years prior to 2020) have an increased risk for COVID-19-related death (odds ratio 1.67). We also find that specific factors contributing to increased mortality are serum glucose levels, systolic blood pressure and waist circumference.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by a Foundation Scheme award to AD from the Canadian Institutes of Health Research. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:All participants signed informed consents prior to participating in the UK Biobank study, which was approved by the North-West Multi-centre Research Ethics Committee (11/NW/0382). All UK Biobank actions are overseen by the UK Biobank Ethics Advisory Committee. All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data underlying the results presented in the study are available from the UK Biobank.
AU  - Morys, Filip
AU  - Dagher, Alain
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205716
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205716
ST  - Metabolic syndrome increases COVID-19-related mortality in the UK Biobank sample (preprint)
T2  - medRxiv
TI  - Metabolic syndrome increases COVID-19-related mortality in the UK Biobank sample (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205716.abstract
ID  - 7788883
ER  - 

TY  - JOUR
AB  - COVID-19 pneumonia produces a heterogeneous array of clinical, biochemical, and radiological findings. Over the last few months of global hurry to optimize a testing strategy, it has been suggested that bedside point-of-care lung ultrasound may have a diagnostic role. We present 3 patients with RT-PCR nasopharyngeal swab-confirmed COVID-19 pneumonia, who had an admission plain chest film reported to be normal by a consultant radiologist, but with significant sonographic abnormalities on bedside ultrasound performed within 24 hours of the chest radiograph. Lung ultrasound may better correlate with the oxygen requirement and overall condition of the patient than chest radiographs - a pertinent consideration given the imminent advance of the pandemic into resource-poor zones where timely access to roentgenological imaging may be sparse.
AD  - Acute Medical Unit, Royal Berkshire Hospital, Reading, UK.
AN  - 33020762
AU  - Mort, D. O.
AU  - Limbu, D.
AU  - Nunan, J.
AU  - Walden, A.
C1  - 10/6/2020
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acute medicine
LA  - eng
N1  - 1747-4892
Mort, D O
Limbu, D
Nunan, J
Walden, A
Journal Article
England
Acute Med. 2020;19(3):162-167.
PY  - 2020
SN  - 1747-4884
SP  - 162-167
ST  - Abnormal Lung Point-of-Care Ultrasound (POCUS) in Suspected Cases of COVID-19 pneumonia with Normal Plain Chest Radiographs - A Case Series
T2  - Acute medicine
TI  - Abnormal Lung Point-of-Care Ultrasound (POCUS) in Suspected Cases of COVID-19 pneumonia with Normal Plain Chest Radiographs - A Case Series
VL  - 19
ID  - 7784977
ER  - 

TY  - JOUR
AB  - BACKGROUND: The new coronavirus disease (COVID-19) has high infection and mortality rates, and has become a pandemic. The infection and mortality rates are lower in Asian countries than in European countries. This study aimed to conduct a survey on the effects of COVID-19 on the capacity to perform gastrointestinal motility tests in Asian countries compared with European countries. METHODS: We used the questionnaire previously established by our team for researchers in European countries. The correlation between the decreased rate of gastrointestinal motility and function tests, and the infection/mortality rates of COVID-19 and stringency of a government's interventions in each country was analysed and protective measures were assessed. RESULTS: In total, 58 gastroenterologists/motility experts in Asian countries responded to this survey. The infection/mortality rates of COVID-19 and Stringency Index had a significant impact on the testing capacity of oesophageal manometry and catheter-based pH monitoring. In European countries, most facilities used filtering facepiece 2/3 (FFP2/3) masks during oesophageal motility studies. Meanwhile, in Asian countries, most facilities used surgical masks. CONCLUSION: The total infection and mortality rates of COVID-19 can affect the rate of gastrointestinal motility testing and the type of protective equipment that must be used.
AD  - Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Diseases (TARGID), University of Leuven, 3000 Leuven, Belgium.
Gastroenterology and Hepatology Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Hatyai 90110, Thailand.
Center of Excellence on Neurogastroenterology and Motility, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Internal Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.
Endoscopy Center for Diagnosis and Treatment, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Department of Medical Innovation, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan.
Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul 03080, Korea.
School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu 15200, Malaysia.
Department of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan.
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, Isehara 259-1193, Japan.
AN  - 33019626
AU  - Mori, H.
AU  - Schol, J.
AU  - Geeraerts, A.
AU  - Huang, I. H.
AU  - Jandee, S.
AU  - Gonlachanvit, S.
AU  - Tseng, P. H.
AU  - Lu, C. L.
AU  - Kamiya, T.
AU  - Kim, N.
AU  - Lee, Y. Y.
AU  - Kuribayashi, S.
AU  - Tack, J.
AU  - Suzuki, H.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/jcm9103189
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Journal of clinical medicine
KW  - Covid-19
SARS-CoV-2
anorectal manometry
breath tests
catheter-based pH-monitoring
infection prevention
motility disorders of the gastrointestinal tract
oesophageal manometry
wireless pH-monitoring (Bravo�])
LA  - eng
N1  - Mori, Hideki
Schol, Jolien
Orcid: 0000-0003-0537-969x
Geeraerts, Annelies
Orcid: 0000-0003-4941-3263
Huang, I-Hsuan
Jandee, Sawangpong
Gonlachanvit, Sutep
Tseng, Ping-Huei
Orcid: 0000-0002-7483-7538
Lu, Ching-Liang
Kamiya, Takeshi
Kim, Nayoung
Lee, Yeong Yeh
Orcid: 0000-0002-6486-7717
Kuribayashi, Shiko
Orcid: 0000-0002-5067-552x
Tack, Jan
Suzuki, Hidekazu
Orcid: 0000-0002-8994-6163
20H3667/Japan Society for the Promotion of Science (JSPS KAKENHI)/
Journal Article
Switzerland
J Clin Med. 2020 Oct 1;9(10):E3189. doi: 10.3390/jcm9103189.
PY  - 2020
SN  - 2077-0383 (Print)
2077-0383
ST  - The Impact of COVID-19 on Gastrointestinal Motility Testing in Asia and Europe
T2  - Journal of clinical medicine
TI  - The Impact of COVID-19 on Gastrointestinal Motility Testing in Asia and Europe
VL  - 9
ID  - 7785093
ER  - 

TY  - JOUR
AB  - BACKGROUND This is a case report of an immunocompromised patient with a history of non-Hodgkin lymphoma and persistent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection who was seronegative and successfully treated with convalescent plasma. CASE REPORT A 63-year-old woman with a past medical history of non-Hodgkin lymphoma in remission while on maintenance therapy with the anti-CD20 monoclonal antibody, obinutuzumab, tested positive for SARS-CoV-2 via nasopharyngeal reverse transcription polymerase chain reaction (RT-PCR) testing over 12 weeks and persistently tested seronegative for immunoglobulin G (IgG) antibodies using SARS-CoV-2 IgG chemiluminescent microparticle immunoassay technology. During this time, the patient experienced waxing and waning of symptoms, which included fever, myalgia, and non-productive cough, but never acquired severe respiratory distress. She was admitted to our hospital on illness day 88, and her symptoms resolved after the administration of convalescent plasma. CONCLUSIONS As the understanding of the pathogenesis of SARS-CoV-2 continues to evolve, we can currently only speculate about the occurrence of chronic infection vs. reinfection. The protective role of antibodies and their longevity against SARS-CoV-2 remain unclear. Since humoral immunity has an integral role in SARS-CoV-2 infection, various phase 3 vaccine trials are underway. In the context of this pandemic, the present case demonstrates the challenges in our understanding of testing and treating immunocompromised patients.
AD  - Department of Medicine, Norwalk Hospital, Norwalk, CT, USA.
Department of Internal Medicine, Yale School of Medicine, New Haven, CT, USA.
Department of Pulmonary and Critical Care Medicine, Norwalk Hospital, Yale School of Medicine, University of Vermont School of Medicine, Norwalk, CT, USA.
Department of Pulmonary and Critical Care Medicine, Norwalk Hospital, Norwalk, CT, USA.
Department of Infectious Disease, Norwalk Hospital, Norwalk, CT, USA.
AN  - 33009361
AU  - Moore, J. L.
AU  - Ganapathiraju, P. V.
AU  - Kurtz, C. P.
AU  - Wainscoat, B.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.12659/ajcr.927812
DP  - NLM
ET  - 2020/10/04
J2  - The American journal of case reports
LA  - eng
N1  - 1941-5923
Moore, Joanna L
Ganapathiraju, Pavan V
Kurtz, Caroline P
Wainscoat, Booth
Journal Article
United States
Am J Case Rep. 2020 Oct 3;21:e927812. doi: 10.12659/AJCR.927812.
PY  - 2020
SN  - 1941-5923
SP  - e927812
ST  - A 63-Year-Old Woman with a History of Non-Hodgkin Lymphoma with Persistent SARS-CoV-2 Infection Who Was Seronegative and Treated with Convalescent Plasma
T2  - American journal of case reports
TI  - A 63-Year-Old Woman with a History of Non-Hodgkin Lymphoma with Persistent SARS-CoV-2 Infection Who Was Seronegative and Treated with Convalescent Plasma
VL  - 21
ID  - 7785815
ER  - 

TY  - JOUR
AB  - Although the practice of strengthening the immune system may not guarantee that people will not contract severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is evidence that suggests that the likelihood and severity of many viral infections can be considerably reduced if appropriate measures are taken to increase the efficacy of the immune response to invading organisms Evidence-based public health measures to reduce viral spread include?personal isolation, physical distancing, wearing facial masks, frequent hand washing with soap and running water, not touching the face, vaccination, etc However once infected, recovery relies on host immunity to eradicate the foreign invaders, with symptomatic management, which is the core management strategy in COVID-19 management guidelines Researchers have observed that severe COVID-19 prevalence and mortality is highest in people with preexisting conditions Eighty percent of these preexisting diseases are lifestyle related Also, the science of strengthening the immune system by adopting appropriate lifestyle changes is still evolving, especially among the suspected and confirmed COVID-19 cases This article briefly highlights the immune response to viral infections including COVID-19 and refers to evidence that healthy lifestyle practices, enshrined as core aspects of lifestyle medicine, can strengthen the immune response to infections This may improve outcome in COVID-19 We therefore recommend specific evidence-based lifestyle intervention measures that should be considered in the management of COVID-19
AU  - Monye, Ifeoma
AU  - Adelowo, Abiodun Bamidele
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Strengthening immunity through healthy lifestyle practices: Recommendations for lifestyle interventions in the management of COVID-19
T2  - Lifestyle Medicine
TI  - Strengthening immunity through healthy lifestyle practices: Recommendations for lifestyle interventions in the management of COVID-19
UR  - https://doi.org/10.1002/lim2.7
ID  - 7788151
ER  - 

TY  - JOUR
AB  - The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) pandemic. While the common cold symptoms are observed in mild cases, COVID-19 is accompanied by multiorgan failure in severe patients. The involvement of different organs in severe patients results in lengthening the hospitalization duration and increasing the mortality rate. In this review, we aimed to investigate the involvement of different organs in COVID-19 patients, particularly in severe cases. Also, we tried to define the potential underlying mechanisms of SARS-CoV2 induced multiorgan failure. The multi-organ dysfunction is characterized by acute lung failure, acute liver failure, acute kidney injury, cardiovascular disease, and as well as a wide spectrum of hematological abnormalities and neurological disorders. The most important mechanisms are related to the direct and indirect pathogenic features of SARS-CoV2. Although the presence of angiotensin-converting enzyme 2, a receptor of SARS-CoV2 in the lung, heart, kidney, testis, liver, lymphocytes, and nervous system was confirmed, there are controversial findings to about the observation of SARS-CoV2 RNA in these organs. Moreover, the organ failure may be induced by the cytokine storm, a result of increased levels of inflammatory mediators, endothelial dysfunction, coagulation abnormalities, and infiltration of inflammatory cells into the organs. Therefore, further investigations are needed to detect the exact mechanisms of pathogenesis. Since the involvement of several organs in COVID-19 patients is important for clinicians, increasing their knowledge may help to improve the outcomes and decrease the rate of mortality and morbidity.
AD  - CAS Key Laboratory of Mental Health, Institute of Psychology, Beijing, China.
Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.
Department of Embryology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Department of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. hassanzadeh@tums.ac.ir.
Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. hassanzadeh@tums.ac.ir.
Legal Medicine Research Center, Legal Medicine Organization, Tehran, Iran. hassanzadeh@tums.ac.ir.
AN  - 33011887
AU  - Mokhtari, T.
AU  - Hassani, F.
AU  - Ghaffari, N.
AU  - Ebrahimi, B.
AU  - Yarahmadi, A.
AU  - Hassanzadeh, G.
C1  - 10/6/2020
C2  - PMC7533045
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s10735-020-09915-3
DP  - NLM
ET  - 2020/10/05
J2  - Journal of molecular histology
KW  - Angiotensin-converting enzyme-2
Covid-19
Coagulation
Cytokine storm
Multi-organ failure
SARS-CoV2
LA  - eng
N1  - 1567-2387
Mokhtari, Tahmineh
Hassani, Fatemeh
Ghaffari, Neda
Ebrahimi, Babak
Yarahmadi, Atousa
Hassanzadeh, Ghomareza
Journal Article
Review
J Mol Histol. 2020 Oct 4:1-16. doi: 10.1007/s10735-020-09915-3.
PY  - 2020
SN  - 1567-2379 (Print)
1567-2379
SP  - 1-16
ST  - COVID-19 and multiorgan failure: A narrative review on potential mechanisms
T2  - Journal of molecular histology
TI  - COVID-19 and multiorgan failure: A narrative review on potential mechanisms
ID  - 7785647
ER  - 

TY  - JOUR
AD  - Sechenov First Moscow State Medical University, Moscow, Russia.
AN  - 33015828
AU  - Moiseev, S.
AU  - Avdeev, S.
AU  - Brovko, M.
AU  - Bulanov, N.
AU  - Tao, E.
AU  - Fomin, V.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/anae.15265
DP  - NLM
ET  - 2020/10/06
J2  - Anaesthesia
LA  - eng
N1  - 1365-2044
Moiseev, S
Orcid: 0000-0002-7232-4640
Avdeev, S
Brovko, M
Bulanov, N
Tao, E
Fomin, V
Letter
England
Anaesthesia. 2020 Oct 5. doi: 10.1111/anae.15265.
PY  - 2020
SN  - 0003-2409
ST  - Outcomes of intensive care unit patients with COVID-19: a nationwide analysis in Russia
T2  - Anaesthesia
TI  - Outcomes of intensive care unit patients with COVID-19: a nationwide analysis in Russia
ID  - 7785240
ER  - 

TY  - JOUR
AB  - Background With emergence of coronavirus-2019 or COVID-19 a diverse number of people have been infected worldwide in a short time, with no specific treatment or vaccine. Infected patients are in danger of creating respiratory failure that necessitating admission to intensive care units (ICU). Thus intensivists (ICU providers) and anesthesiologists must be ready for the newcomers to ICU and to sustain care for them. Method We performed a narrative review via searching in three databases PubMed, Google Scholar and Embase for all studies that mentioned all intensive care admission rates for who infected with coronavirus 2019, manual searching also completed. All the selected reviews were limited to the English language and date also. Result Five researches referred to the rate of ICU admission, about 9.3% of all cases. Male patients were more comparing to female (59% to 41%), median age range were (40-56) years, cases with co-existing diseases range from 23.7%-51%, with ICU admission rate being 5%-32%. An immense number of patients received oxygen therapy (41.3%-76.81%), while 6.7% of cases were under non-invasive ventilation with range from 4.9%-24% and just 3.6% of patients who received invasive ventilation with range from 3.3%-12.32%. Finally the mortality rate was 2.6%. Conclusion The novel virus, COVID-19 has shown to more likely affect older male with underlying conditions such as hypertension, diabetes and others, a point that could expose them to fatal respiratory symptoms, including respiratory failure. So a quite enough of patients might need oxygen support and ICU admission. Copyright © 2020, Advanced Scientific Research. All rights reserved.
AD  - (Mohammadi) Anesthesiology and intensive care department (FCCM). TUMS, Tehran, Iran, Islamic Republic of (Sasaa) AL-Sader teaching hospital, Al-Mustaqbal college university, department of anesthesia and intensive care unit, Iraq (Al-Emran) AL-Hussaini teaching hospital, Al-Mustaqbal college university, Department of anesthesia and intensive care unit, Iraq (Alhamaidah) AL-Rifaei General Hospital, Iraq (Alhamaidah, Abd-Alzahra) Department of Anesthesia, College of Health and Medical. Technology, Al-Ayen University, Iraq (Roomi) College of Health and Medical Technology, Al-Ayen University, Iraq (Kabbi, Hussaini, Naqeeb) AL-Hussaini teaching hospital, Iraq
M. Mohammadi, Anesthesiology and intensive care department (FCCM). TUMS, Tehran, Iran, Islamic Republic of. E-mail: mohammady_m2007@yahoo.com
AN  - 2005131282
AU  - Mohammadi, M.
AU  - Sasaa, M. A. Z.
AU  - Al-Emran, A. F.
AU  - Alhamaidah, M. F.
AU  - Roomi, A. B.
AU  - Abd-Alzahra, H. S.
AU  - Kabbi, M. S. A. L.
AU  - Hussaini, S. A. L.
AU  - Naqeeb, N. A.
C1  - 10/6/2020
DA  - April-June
DB  - Embase
DO  - http://dx.doi.org/10.31838/ijpr/2020.12.02.355
DP  - Ovid Technologies
IS  - 2
KW  - And mortality rate
Coronavirus-2019
covid-19
ICU admission
Mechanical ventilation
Oxygen support
adult
article
controlled study
coronavirus disease 2019
diabetes mellitus
Embase
English (language)
female
human
hypertension
intensive care unit
male
Medline
mortality rate
narrative
noninvasive ventilation
oxygen therapy
respiratory failure
systematic review
oxygen
LA  - English
PY  - 2020
SN  - 0975-2366 (electronic)
0975-2366
SP  - 2632-2635
ST  - Intensive care admission rate due to COVID-2109
T2  - International Journal of Pharmaceutical Research
TI  - Intensive care admission rate due to COVID-2109
UR  - http://www.ijpronline.com/DownloadFile.aspx?FilePath=d4004650-2bd2-4679-8eca-d647a6307f8c.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005131282
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.31838%2Fijpr%2F2020.12.02.355&issn=0975-2366&isbn=&volume=12&issue=2&spage=2632&pages=2632-2635&date=2020&title=International+Journal+of+Pharmaceutical+Research&atitle=Intensive+care+admission+rate+due+to+COVID-2109&aulast=Mohammadi&pid=%3Cauthor%3EMohammadi+M.%2CSasaa+M.A.Z.%2CAl-Emran+A.F.%2CAlhamaidah+M.F.%2CRoomi+A.B.%2CAbd-Alzahra+H.S.%2CKabbi+M.S.A.L.%2CHussaini+S.A.L.%2CNaqeeb+N.A.%3C%2Fauthor%3E&%3CAN%3E2005131282%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 12
ID  - 7783014
ER  - 

TY  - JOUR
AB  - Objective: To address the issue of limited national data on the prevalence and distribution of underlying conditions among COVID-19 deaths between sexes and across age groups. Patients and Methods: All adult (=18 years) deaths recorded in England and Wales (March 1, 2020, to May 12, 2020) were analyzed retrospectively. We compared the prevalence of underlying health conditions between COVID and non-COVID-related deaths during the COVID-19 pandemic and the age-standardized mortality rate (ASMR) of COVID-19 compared with other primary causes of death, stratified by sex and age group. Result(s): Of 144,279 adult deaths recorded during the study period, 36,438 (25.3%) were confirmed COVID deaths. Women represented 43.2% (n=15,731) of COVID deaths compared with 51.9% (n=55,980) in non-COVID deaths. Overall, COVID deaths were younger than non-COVID deaths (82 vs 83 years). ASMR of COVID-19 was higher than all other common primary causes of death, across age groups and sexes, except for cancers in women between the ages of 30 and 79 years. A linear relationship was observed between ASMR and age among COVID-19 deaths, with persistently higher rates in men than women across all age groups. The most prevalent reported conditions were hypertension, dementia, chronic lung disease, and diabetes, and these were higher among COVID deaths. Pre-existing ischemic heart disease was similar in COVID (11.4%) and non-COVID (12%) deaths. Conclusion(s): In a nationwide analysis, COVID-19 infection was associated with higher age-standardized mortality than other primary causes of death, except cancer in women of select age groups. COVID-19 mortality was persistently higher in men and increased with advanced age. Copyright © 2020 Mayo Foundation for Medical Education and Research
AD  - (Mohamed, Rashid, Mamas) Keele Cardiovascular Research Group, Centre for Prognosis Research, Institutes of Applied Clinical Science and Primary Care and Health Sciences, Keele University, Keele, United Kingdom (Mohamed, Rashid, Mamas) Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, United Kingdom (Gale, Wu) Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom (Gale) Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom (Gale) Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom (Kontopantelis) Division of Informatics, Imaging and Data Science, University of Manchester, Manchester, United Kingdom (Doran) Department of Health Sciences, University of York, York, United Kingdom (de Belder) National Institute for Cardiovascular Outcomes Research, Barts Health NHS Trust, United Kingdom (Asaria) London School of Economics, London, United Kingdom (Luscher) Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (Stephenson, Denwood, Roebuck) NHS Digital, Leeds, United Kingdom (Deanfield) University College London, London, United Kingdom
M.A. Mamas, Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute for Primary Care and Health Sciences, Keele University, University Drive, Keele, United Kingdom. E-mail: mamasmamas1@yahoo.co.uk
AN  - 2007954597
AU  - Mohamed, M. O.
AU  - Gale, C. P.
AU  - Kontopantelis, E.
AU  - Doran, T.
AU  - de Belder, M.
AU  - Asaria, M.
AU  - Luscher, T.
AU  - Wu, J.
AU  - Rashid, M.
AU  - Stephenson, C.
AU  - Denwood, T.
AU  - Roebuck, C.
AU  - Deanfield, J.
AU  - Mamas, M. A.
C1  - 10/6/2020
DA  - October
DB  - Embase
DO  - http://dx.doi.org/10.1016/j.mayocp.2020.07.009
DP  - Ovid Technologies
IS  - 10
KW  - adult
advanced cancer
article
cancer patient
cause of death
chronic lung disease
controlled study
coronavirus disease 2019
dementia
diabetes mellitus
England
female
groups by age
human
hypertension
ischemic heart disease
major clinical study
male
mortality rate
pandemic
prevalence
retrospective study
sex difference
Wales
LA  - English
PY  - 2020
SN  - 0025-6196
1942-5546
SP  - 2110-2124
ST  - Sex Differences in Mortality Rates and Underlying Conditions for COVID-19 Deaths in England and Wales
T2  - Mayo Clinic Proceedings
TI  - Sex Differences in Mortality Rates and Underlying Conditions for COVID-19 Deaths in England and Wales
UR  - http://www.journals.elsevier.com/mayo-clinic-proceedings
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007954597
VL  - 95
ID  - 7782908
ER  - 

TY  - JOUR
AB  - The COVID-19 outbreak emphasizes the need for alternative methods for data gathering and collaboration among researchers in a virtual research environment. One experimental design that is well suited in a social distancing research context is the single-case experimental design (SCD). SCDs can handle disruptions as (a) they do not require large groups gathering for data collection or intervention administration, (b) interventions are administered individually and in some cases remotely, (c) no comparison group is needed, and (d) they are adaptive and flexible designs. The purpose of this article is to introduce the mobile application, SCD-MVA (2019), developed to assists in the design of an SCD, data gathering, data analysis, and remote collaboration. The application allows data management and data sharing among researchers, provides an in real time visualization of the gathered data, stimulates interaction between researchers in terms of designing the SCD, gathering the data, and analyzing the gathered data, and does all these things with no need for in-person meetings of the research team. © 2020 Wiley Periodicals LLC
AD  - Department of Educational and Counseling Psychology, University at Albany-SUNY, Albany, NY, United States
Department of Educational Theory and Practice, University at Albany-SUNY, Albany, NY, United States
Department of Educational Measurement and Research, University of South Florida, Tampa, FL, United States
AU  - Moeyaert, M.
AU  - Bursali, S.
AU  - Ferron, J. M.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1002/hbe2.223
J2  - Hum. Behav. Emerg. Technol.
KW  - masked visual analysis
multiple baseline design
single-case experimental design
“SCD-MVA�?mobile application
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Moeyaert, M.; Department of Educational and Counseling Psychology, University at Albany-SUNYUnited States; email: mmoeyaert@albany.edu
Funding details: Institute of Education Sciences, IES
Funding details: U.S. Department of Education, ED, R305D190022
Funding text 1: This research was supported by the Institute of Education Sciences, U.S. Department of Education, through grant R305D190022. The content is solely the responsibility of the author and does not necessarily represent the official views of the Institute of Education Sciences, or the U.S. Department of Education.
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PY  - 2020
SN  - 25781863 (ISSN)
ST  - SCD-MVA: A mobile application for conducting single-case experimental design research during the pandemic
T2  - Human Behavior and Emerging Technologies
TI  - SCD-MVA: A mobile application for conducting single-case experimental design research during the pandemic
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091725449&doi=10.1002%2fhbe2.223&partnerID=40&md5=195f88c3228e445c8db2222fe739e0b9
ID  - 7783330
ER  - 

TY  - JOUR
AN  - 33019958
AU  - Mirian, A.
AU  - Jenkins, M. E.
AU  - Watling, C. J.
AU  - Venance, S. L.
AU  - Florendo-Cumbermack, A.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1017/cjn.2020.218
DP  - NLM
ET  - 2020/10/07
J2  - The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques
LA  - eng
N1  - Mirian, Ario
Orcid: 0000-0002-1477-9196
Jenkins, Mary E
Watling, Christopher J
Venance, Shannon L
Florendo-Cumbermack, Anita
Journal Article
England
Can J Neurol Sci. 2020 Oct 6:1-10. doi: 10.1017/cjn.2020.218.
PY  - 2020
SN  - 0317-1671 (Print)
0317-1671
SP  - 1-10
ST  - Finding the "right" Canadian neurology residency program during the COVID-19 era
T2  - Canadian journal of neurological sciences Le journal canadien des sciences neurologiques
TI  - Finding the "right" Canadian neurology residency program during the COVID-19 era
ID  - 7785067
ER  - 

TY  - JOUR
AD  - The University of Chicago Medicine, Chicago, IL
AN  - 146192809. Language: English. Entry Date: In Process. Revision Date: 20201005. Publication Type: Article. Supplement Title: 2020 Supplement. Journal Subset: Biomedical
AU  - Miller, Tamari A.
AU  - Kalantari, Sara
AU  - Grinstein, Jonathan
AU  - Nguyen, Ann
AU  - Chung, Bow Young
AU  - Sarswat, Nitasha
AU  - Kim, Gene
AU  - Nadeem, Urooba
AU  - Husain, Aliya
AU  - Holzhauser, Luise Heddy
AU  - Mehta, Natasha
AU  - Kagan, Viktoriya
AU  - Labuhn, Colleen
AU  - Jeevanandam, Valluvan
AU  - Song, Tae
AU  - Smith, Bryan
C1  - 10/6/2020
DB  - cin20
DO  - 10.1016/j.cardfail.2020.09.214
DP  - EBSCOhost
IS  - 10
N1  - Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9442138.
PY  - 2020
SN  - 1071-9164
SP  - S73-S73
ST  - A Case of Suspected Covid 19 Related Cardiomyopathy
T2  - Journal of Cardiac Failure
TI  - A Case of Suspected Covid 19 Related Cardiomyopathy
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=146192809&site=ehost-live
VL  - 26
ID  - 7784715
ER  - 

TY  - JOUR
AB  - BACKGROUND: The mortality rate associated with Covid-19 varies considerably among studies and determinants of this variability are not well characterized. METHODS: A systematic review of peer-reviewed literature published through March 31, 2020 was performed to estimate the mortality rate among hospitalized patients in China with a confirmed diagnosis of Covid-19. Hospital mortality rates were estimated using an inverse variance-weighted random-effects meta-analysis model. Funnel plot symmetry was evaluated for small-study effects, a one-study removed sensitivity analysis assessed the influence of individual studies on the pooled mortality rate, and metaregression assessed the association of potential confounding variables with mortality rates. RESULTS: The review included 16 observational studies involving 1832 hospitalized patients with a diagnosis of Covid-19. The surveillance period among studies ranged from December 16, 2019 to February 23, 2020. The median patient age was 53 years and 53% were males. A total of 38.5% of patients presented with at least 1 comorbidity, most commonly hypertension (24.0%), cardiac disease (15.1%), and diabetes mellitus (14.4%). Fever and cough, reported in 84.8% and 61.7% of patients respectively, were the most common patient symptoms. The pooled mortality rate was 9.9% (95% confidence interval 6.1% to 14.5%). Funnel plot asymmetry was not observed and the meta-analysis results were not substantially influenced by any single study since the pooled mortality rate ranged from 8.9% to 11.1% following iterative removal of one study at a time. Substantial heterogeneity in the mortality rate was identified among studies (I�?�?7%; P �?001). In a metaregression that included demographics, patient risk factors, and presenting symptoms, only a higher prevalence of diabetes mellitus was associated with a higher mortality rate (P�?�?03). CONCLUSIONS: In a meta-analysis of hospitalized patients in China with a diagnosis of Covid-19, the mortality rate was 9.9% and a higher diabetes mellitus prevalence was independently associated with a worse prognosis. The independent influence of diabetes mellitus with Covid-19 mortality should be viewed as hypothesis-generating and warrants further study.
AN  - 33019426
AU  - Miller, L. E.
AU  - Bhattacharyya, R.
AU  - Miller, A. L.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1097/md.0000000000022439
DP  - NLM
ET  - 2020/10/07
IS  - 40
J2  - Medicine
LA  - eng
N1  - 1536-5964
Miller, Larry E
Bhattacharyya, Ruemon
Miller, Anna L
Journal Article
United States
Medicine (Baltimore). 2020 Oct 2;99(40):e22439. doi: 10.1097/MD.0000000000022439.
PY  - 2020
SN  - 0025-7974
SP  - e22439
ST  - Diabetes mellitus increases the risk of hospital mortality in patients with Covid-19: Systematic review with meta-analysis
T2  - Medicine
TI  - Diabetes mellitus increases the risk of hospital mortality in patients with Covid-19: Systematic review with meta-analysis
VL  - 99
ID  - 7785100
ER  - 

TY  - JOUR
AD  - (Mian) Afdeling Klinische Farmacie Medisch Spectrum Twente (Van Der Zanden, De Wildt) Nederlands Kenniscentrum Farmacotherapie bij Kinderen, Netherlands (De Hoop-Sommen) Nederlands Kenniscentrum Farmacotherapie bij Kinderen, KNMP, Netherlands
AN  - 632947846
AU  - Mian, P.
AU  - Van Der Zanden, T.
AU  - De Hoop-Sommen, M.
AU  - De Wildt, S.
C1  - 10/6/2020
DA  - 29 May
DB  - Embase
DP  - Ovid Technologies
IS  - 22-23
KW  - article
child
coronavirus disease 2019
human
LA  - Dutch
PY  - 2020
SN  - 0031-6911
SP  - 12-15
ST  - Need more knowledge about children with COVID-19. [Dutch]
T2  - Pharmaceutisch Weekblad
TI  - Need more knowledge about children with COVID-19. [Dutch]
TT  - Meer kennis nodig over kinderen met COVID-19.
UR  - http://www.pw.nl/archief
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632947846
VL  - 155
ID  - 7782920
ER  - 

TY  - JOUR
AB  - OBJECTIVE: The weather-related conditions change the ecosystem and pose a threat to social, economic and environmental development. It creates unprecedented or unanticipated human health problems in various places or times of the year. Africa is the world's second largest and most populous continent and has relatively changeable weather conditions. The present study aims to investigate the impact of weather conditions, heat and humidity on the incidence and mortality of COVID-19 pandemic in various regions of Africa. MATERIALS AND METHODS: In this study, 16 highly populated countries from North, South, East, West, and Central African regions were selected. The data on COVID-19 pandemic including daily new cases and new deaths were recorded from World Health Organization. The daily temperature and humidity figures were obtained from the weather web "Time and Date". The daily cases, deaths, temperature and humidity were recorded from the date of appearance of first case of "Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)" in the African region, from Feb 14 to August 2, 2020. RESULTS: In African countries, the daily basis mean temperature from Feb 14, 2020 to August 2, 2020 was 26.16�u0.12��C, and humidity was 57.41�u0.38%. The overall results revealed a significant inverse correlation between humidity and the number of cases (r= -0.192, p0.001) and deaths (r= -0.213, p0.001). Similarly, a significant inverse correlation was found between temperature and the number of cases (r= -0.25, p0.001) and deaths (r=-0.18, p0.001). Furthermore, the regression results showed that with 1% increase in humidity the number of cases and deaths was significantly reduced by 3.6% and 3.7% respectively. Congruently, with 1��C increase in temperature, the number of cases and deaths was also significantly reduced by 15.1% and 10.5%, respectively. CONCLUSIONS: Increase in relative humidity and temperature was associated with a decrease in the number of daily cases and deaths due to COVID-19 pandemic in various African countries. The study findings on weather events and COVID-19 pandemic have an impact at African regional levels to project the incidence and mortality trends with regional weather events which will enhance public health readiness and assist in planning to fight against this pandemic.
AD  - Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. sultanmeo@hotmail.com.
AN  - 33015822
AU  - Meo, S. A.
AU  - Abukhalaf, A. A.
AU  - Alomar, A. A.
AU  - Aljudi, T. W.
AU  - Bajri, H. M.
AU  - Sami, W.
AU  - Akram, J.
AU  - Akram, S. J.
AU  - Hajjar, W.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23069
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Meo, S A
Abukhalaf, A A
Alomar, A A
Aljudi, T W
Bajri, H M
Sami, W
Akram, J
Akram, S J
Hajjar, W
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9753-9759. doi: 10.26355/eurrev_202009_23069.
PY  - 2020
SN  - 1128-3602
SP  - 9753-9759
ST  - Impact of weather conditions on incidence and mortality of COVID-19 pandemic in Africa
T2  - European review for medical and pharmacological sciences
TI  - Impact of weather conditions on incidence and mortality of COVID-19 pandemic in Africa
VL  - 24
ID  - 7785243
ER  - 

TY  - JOUR
AB  - Background In the current coronavirus disease-2019 (COVID-19) pandemic, the pattern of hospital admissions for acute ST-elevation myocardial infarction (STEMI) is changing, and increased mortality and morbidity is being noted in these patients Cardiac manifestations of COVID-19 are complex and include STEMI, myocarditis, myocardial injury, and cardiomyopathy The objective of our study was to compare the data of patients with STEMI presenting in COVID-19 versus the non-COVID-19 era Methods We analyzed the clinical and angiographic characteristics of STEMI patients undergoing primary percutaneous coronary intervention (PCI) at our center The primary outcome variables were admission rate for STEMI, mean total ischemic time (TIT), coronary artery disease burden, mean ejection fraction, and in-hospital mortality for three defined groups Group A consisted of patients who underwent primary PCI from March through April 2020 Group B included patients who underwent primary PCI from January to February 2020 Group C consisted of patients who underwent primary PCI from March to April 2019 We then compared the data among the three groups and calculated any significant p-value (p&amp;lt; 001) Results In Group A, 1139 patients were admitted for primary PCI The mean admission rate was 18 6 +/- 4 36 admissions per day There were 1535 patients in Group B and an admission rate of 26 01 +/- 4 90 (p&amp;lt; 001 compared to Group A) In Group C, there were 1537 patients and an admission rate of 24 8 +/- 4 55 (p&amp;lt; 001, compared to Group A) The mean TIT was 429 25 +/- 272 16 minutes for Group A, 359 78 +/- 148 04 minutes for Group B, and 346 75 +/- 207 31 minutes for Group C (p&amp;lt; 001) A higher mortality rate was noted in Group A (COVID-19 era) versus Group C (non-COVID-19 era;p&amp;lt; 001) Conclusions A lower admission rate, higher TIT, and higher mortality rates were noted in patients with acute STEMI during the COVID-19 pandemic compared to the pre-COVID era During the COVID-19 pandemic, physicians should bear in mind that patients with STEMI have increased mortality and morbidity Where possible, efforts should be made for timely management of these critical patients to decrease mortality
AU  - Mengal, Naeem
AU  - Saghir, Tahir
AU  - Rizvi, Syed N. Hassan
AU  - Khan, Naveedullah
AU  - Qamar, Nadeem
AU  - Masood, Sobia
AU  - Badini, Abida
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Acute ST-Elevation Myocardial Infarction Before and During the COVID-19 Pandemic: What is the Clinically Significant Difference?
T2  - Cureus
TI  - Acute ST-Elevation Myocardial Infarction Before and During the COVID-19 Pandemic: What is the Clinically Significant Difference?
UR  - https://doi.org/10.7759/cureus.10523
ID  - 7788409
ER  - 

TY  - JOUR
AB  - BACKGROUND The global outbreak of human severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infection represents an urgent need for readily available, accurate and rapid diagnostic tests. Nucleic acid testing of respiratory tract specimens for SARS-CoV-2 is the current gold standard for diagnosis of coronavirus disease 2019 (COVID-19). However, the diagnostic accuracy of reverse transcription polymerase chain reaction (RT-PCR) tests for detecting SARS-CoV-2 nucleic acid may be lower than optimal. The detection of SARS-CoV-2-specific antibodies should be used as a serological non-invasive tool for the diagnosis and management of SARS-CoV-2 infection. AIM To investigate the diagnostic value of SARS-CoV-2 IgM/IgG and nucleic acid detection in COVID-19. METHODS We retrospectively analyzed 652 suspected COVID-19 patients, and 206 non-COVID-19 patients in Wuhan Integrated TCM and Western Medicine Hospital. Data on SARS-CoV-2 nucleic acid tests and serum antibody tests were collected to investigate the diagnostic value of nucleic acid RT-PCR test kits and immunoglobulin (Ig)M/IgG antibody test kits. The j2 test was used to compare differences between categorical variables. A 95% confidence interval (CI) was provided by the Wilson score method. All analyses were performed with IBM SPSS Statistics version 22.0 (IBM Corp., Armonk, NY, United States). RESULTS Of the 652 suspected COVID-19 patients, 237 (36.3%) had positive nucleic acid tests, 311 (47.7%) were positive for IgM, and 592 (90.8%) were positive for IgG. There was a significant difference in the positive detection rate between the IgM and IgG test groups (P  0.001). Using the RT-PCR results as a reference, the specificity, sensitivity, and accuracy of IgM/IgG combined tests for SARS-CoV-2 infection were 98.5%, 95.8%, and 97.1%, respectively. Of the 415 suspected COVID-19 patients with negative nucleic acid test results, 366 had positive IgM/IgG tests with a positive detection rate of 88.2%. CONCLUSION Our data indicate that serological IgM/IgG antibody combined test had high sensitivity and specificity for the diagnosis of SARS-CoV-2 infection, and can be used in combination with RT-PCR for the diagnosis of SARS-CoV-2 infection. Copyright © The Author(s) 2020.
AD  - (Meng) Department of Pulmonary and Critical Care Medicine and Department of Gastrointestinal Surgery, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430022, China (Peng) Department of Respiratory Medicine, General Hospital of the Yangtze River Shipping, Wuhan, Hubei Province 430015, China (Wei) Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430000, China (Yang) Department of Gastroenterology, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430022, China (Li, Xiong) Department of Transfusion Medicine, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430022, China (Qu) Department of Gastrointestinal Surgery, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430022, China (Wu) Department of Infection Management and Disease Control, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China (Hu) Department of Clinical Microbiology and Molecular Biology, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technologz, Wuhan, Hubei Province 430022, China (Yu) Department of General Surgery, Peking Union Medicine College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China (Su) Department of Science and Education, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province 430022, China
W. Su, Department of Science and Education, Wuhan Integrated TCM and Western Medicine Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 215 Zhongshan Avenue, Wuhan, Hubei Province 430022, China. E-mail: 501820747@qq.com
AN  - 632998313
AU  - Meng, Q. B.
AU  - Peng, J. J.
AU  - Wei, X.
AU  - Yang, J. Y.
AU  - Li, P. C.
AU  - Qu, Z. W.
AU  - Xiong, Y. F.
AU  - Wu, G. J.
AU  - Hu, Z. M.
AU  - Yu, J. C.
AU  - Su, W.
C1  - 10/6/2020
DA  - 01 Oct
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i19.4360
DP  - Ovid Technologies
IS  - 19
KW  - covid-19
Diagnosis
Immunoglobulin G
Immunoglobulin M
Nucleic acid detection
SARS-CoV-2
adult
antibody blood level
article
controlled study
coronavirus disease 2019
diagnostic test accuracy study
diagnostic value
female
human
human tissue
major clinical study
male
retrospective study
reverse transcription polymerase chain reaction
sensitivity and specificity
United States
western medicine
endogenous compound
immunoglobulin G antibody
nucleic acid
LA  - English
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 4360-4369
ST  - Clinical application of combined detection of SARS-CoV-2-specific antibody and nucleic acid
T2  - World Journal of Clinical Cases
TI  - Clinical application of combined detection of SARS-CoV-2-specific antibody and nucleic acid
UR  - https://f6publishing.blob.core.windows.net/b2aeafb8-69a4-4fd3-823c-92d010bdea7c/WJCC-8-4360.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998313
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i19.4360&issn=2307-8960&isbn=&volume=8&issue=19&spage=4360&pages=4360-4369&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Clinical+application+of+combined+detection+of+SARS-CoV-2-specific+antibody+and+nucleic+acid&aulast=Meng&pid=%3Cauthor%3EMeng+Q.-B.%2CPeng+J.-J.%2CWei+X.%2CYang+J.-Y.%2CLi+P.-C.%2CQu+Z.-W.%2CXiong+Y.-F.%2CWu+G.-J.%2CHu+Z.-M.%2CYu+J.-C.%2CSu+W.%3C%2Fauthor%3E&%3CAN%3E632998313%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 8
ID  - 7782821
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To evaluate whether clinical and social risk factors are associated with negative outcomes for COVID-19 disease among Brazilian pregnant and postpartum women. METHODS: A secondary analysis was conducted of the official Acute Respiratory Syndrome Surveillance System database. Pregnant and postpartum women diagnosed with COVID-19 ARDS until July 14, 2020, were included. Adverse outcomes were a composite endpoint of either death, admission to the intensive care unit (ICU), or mechanical ventilation. Risk factors were examined by multiple logistic regression. RESULTS: There were 2475 cases of COVID-19 ARDS. Among them, 23.8% of women had the composite endpoint and 8.2% died. Of those who died, 5.9% were not hospitalized, 39.7% were not admitted to the ICU, 42.6% did not receive mechanical ventilation, and 25.5% did not have access to respiratory support. Multivariate analysis showed that postpartum period, age over 35 years, obesity, diabetes, black ethnicity, living in a peri-urban area, no access to Family Health Strategy, or living more than 100 km from the notification hospital were associated with an increased risk of adverse outcomes. CONCLUSION: Clinical and social risk factors and barriers to access health care are associated with adverse outcomes among maternal cases of COVID-19 ARDS in Brazil.
AD  - São Paulo State University (UNESP), Medical School of Botucatu - Botucatu, SP, Brazil.
Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil.
Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, PE, Brazil.
Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Universidade Federal de Campina Grande (UFCG), Campina Grande, PB, Brazil.
Department of Health, Life Cycles and Society, School of Public Health, University of São Paulo (USP), São Paulo, SP, Brazil.
Escola de Saúde Pública do Cear֙, Fortaleza, CE, Brazil.
Universidade Federal de Santa Catarina (UFSC), Department of Gynecology and Obstetrics, Florian�Qpolis, SC, Brazil.
Universidade Federal de São Carlos (UFSCAR), Department of Medicine, São Carlos, SP, Brazil.
AN  - 33011966
AU  - Menezes, M. O.
AU  - Takemoto, M. L. S.
AU  - Nakamura-Pereira, M.
AU  - Katz, L.
AU  - Amorim, M. M. R.
AU  - Salgado, H. O.
AU  - Melo, A.
AU  - Diniz, C. S. G.
AU  - de Sousa, L. A. R.
AU  - Magalhaes, C. G.
AU  - Knobel, R.
AU  - Andreucci, C. B.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1002/ijgo.13407
DP  - NLM
ET  - 2020/10/05
J2  - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
KW  - Covid-19
Health services accessibility
Health status indicators
Maternal death
LA  - eng
N1  - 1879-3479
Menezes, Mariane O
Takemoto, Ma�Tra L S
Nakamura-Pereira, Marcos
Katz, Leila
Amorim, Melania M R
Salgado, Heloisa O
Melo, Adriana
Diniz, Carmen S G
de Sousa, Liduina A R
Magalhaes, Claudia G
Knobel, Roxana
Andreucci, Carla B
Brazilian Group of Studies for COVID-19, Pregnancy
Journal Article
United States
Int J Gynaecol Obstet. 2020 Oct 4. doi: 10.1002/ijgo.13407.
PY  - 2020
SN  - 0020-7292
ST  - Risk factors for adverse outcomes among pregnant and postpartum women with acute respiratory distress syndrome due to COVID-19 in Brazil
T2  - International journal of gynaecology and obstetrics: official organ of International Federation of Gynaecology and Obstetrics
TI  - Risk factors for adverse outcomes among pregnant and postpartum women with acute respiratory distress syndrome due to COVID-19 in Brazil
ID  - 7785637
ER  - 

TY  - JOUR
AB  - PURPOSE: To review the literature on the use of povidone prior to dental treatment for the reduction of viruses in the oral cavity. METHODS: PubMed and Cochrane databases published from January 2019 to June 2020 were reviewed. Studies that met the inclusion criteria were reviewed by two authors separately. A qualitative review of the data was performed. RESULTS: There were no randomized controlled trials or clinical observation studies on the curative or preventive effect of povidone against COVID-19, but there are clinical trial protocols in the recruitment process. The use of a dose between 0.2% to 2.5% is recommended four times a day for 15-30 seconds. CLINICAL SIGNIFICANCE: Povidone mouthwash could be a viable solution before dental care that should be studied to reduce the viral load off COVID-19.
AD  - Regional Institute of Health Research, National University of Caaguazú, Coronel Oviedo, Paraguay, julieta_mendez92@hotmail.com.
National University of Caaguazú, Coronel Oviedo, Paraguay.
AN  - 33017527
AU  - Mendez, J.
AU  - Villasanti, U.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DP  - NLM
ET  - 2020/10/06
IS  - 5
J2  - American journal of dentistry
LA  - eng
N1  - Mendez, Julieta
Villasanti, Ulises
Journal Article
Review
United States
Am J Dent. 2020 Oct;33(5):248-250.
PY  - 2020
SN  - 0894-8275 (Print)
0894-8275
SP  - 248-250
ST  - Use of povidone as a mouthrinse to decrease the viral load of Covid-19 before dental care: Review of the literature
T2  - American journal of dentistry
TI  - Use of povidone as a mouthrinse to decrease the viral load of Covid-19 before dental care: Review of the literature
VL  - 33
ID  - 7785129
ER  - 

TY  - JOUR
AB  - BACKGROUND: The study aim is to share our experience in hospital re-organization and management of paediatric traumatology in the early stage of COVID-19 pandemic. We centralized paediatric traumatology supposing a reduction of ER admissions, with increased severity of conditions, and a change in fracture patterns and consequently re-organized our structure. The COVID-19 epidemic in Europe has seen Italy as the first focus starting from the 21st of February 2020. Lombardy has been the most affected area. The initial NHS approach determined a high percentage of hospital admissions that led to early overload of hospitals, and we had to reorganize our structure to face the emergency. METHODS: We retrospectively evaluated the admission and treatment data to observe the epidemiological evolution of paediatric trauma during the lockdown ordinance and compared them with the same period in 2019. RESULTS: We found a reduction of 78% paediatric visits in the ER but no decrease in the amount of paediatric fractures, rather we found a rate of paediatric fractures increased by 21,62 %. The upper limb fractures being the most representative. CONCLUSIONS: Our expectations were confirmed. We believe that the reorganization and the guidelines by us designed has been effective to spare resources and subtract the paediatric traumatology load from those hospitals dealing with an unexpected number of critical COVID-19 patients. Even if we experienced a significant reduction of paediatric admissions to our trauma E.R., the presence of a determined number of fractures justifies the necessity of a specialized hub to collect all paediatric fractures.
AD  - Ortopedia e Traumatologia Pediatrica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy.
Ortopedia e Traumatologia Pediatrica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy - daniele.priano@gmail.com.
Prima Clinica Ortopedica, ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO, Milan, Italy.
Laboratory of Applied Biomechanics, Department of Biomedical Sciences for Health, Università degli studi di Milano, Milan, Italy.
Deparment of Biomedical Sciences for Health, Research Center for Adult and Pediatric Rheumatic Disease (RECAP-RD), Università degli Studi di Milano, Milan, Italy.
AN  - 33016683
AU  - Memeo, A.
AU  - Priano, D.
AU  - Caldarini, C.
AU  - Trezza, P.
AU  - Laquidara, M.
AU  - Montanari, L.
AU  - Randelli, P.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.23736/s0026-4946.20.05910-1
DP  - NLM
ET  - 2020/10/06
J2  - Minerva pediatrica
LA  - eng
N1  - 1827-1715
Memeo, Antonio
Priano, Daniele
Caldarini, Camilla
Trezza, Paolo
Laquidara, Melania
Montanari, Lucrezia
Randelli, Pietro
Journal Article
Italy
Minerva Pediatr. 2020 Oct 5. doi: 10.23736/S0026-4946.20.05910-1.
PY  - 2020
SN  - 0026-4946
ST  - How the pandemic spread of COVID-19 affected children's traumatology in Italy: changes of numbers, anatomical locations, and severity
T2  - Minerva pediatrica
TI  - How the pandemic spread of COVID-19 affected children's traumatology in Italy: changes of numbers, anatomical locations, and severity
ID  - 7785184
ER  - 

TY  - JOUR
AB  - Introduction: Choriocarcinoma is a rare neoplasm, which is commonly treated with chemotherapy. However, in some cases, it is managed by surgical intervention to save the patient's life. Here, we present a rare case of uterine rupture associated with chorio-carcinoma in a patient with COVID-19 infection. Case Presentation: We present the case of a 34-year-old woman with choriocarcinoma, complicated by uterine rupture after the first course of chemotherapy, and concurrent COVID-19 infection. The patient underwent an emergency hysterectomy and survived after transferring to an isolated intensive care unit room. Conclusion(s): During the COVID-19 pandemic, it is suggested to perform optimal surgery in the emergency setting to prevent further complications. Copyright © 2020, Author(s).
AD  - (Mehr, Payandeh, Nazari) Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, Islamic Republic of (Ayatollahi) Solid tumor Research Center, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, Islamic Republic of (Mohammadi) Department of Radiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, Islamic Republic of (Gharebaghi) Department of Infectious Disease, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, Islamic Republic of (Fakari) Student Research Committee, Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of
S.G.D. Mehr, Department of Obstetrics and Gynecology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran, Islamic Republic of. E-mail: dr.ghassemian@yahoo.com
AN  - 2005153375
AU  - Mehr, S. G. D.
AU  - Ayatollahi, H.
AU  - Mohammadi, A.
AU  - Gharebaghi, N.
AU  - Fakari, F. R.
AU  - Payandeh, S. M.
AU  - Nazari, L.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.5812/ijcm.104080
DP  - Ovid Technologies
IS  - 9
KW  - Choriocarcinoma
Coronavirus Infections
Uterine Rupture
adult
article
cancer chemotherapy
cancer patient
cancer surgery
cancer survival
case report
clinical article
complication
coronavirus disease 2019
female
human
hysterectomy
intensive care unit
pandemic
prevention
uterus rupture
LA  - English
PY  - 2020
SN  - 2538-4422
2538-497X
SP  - 1-4
ST  - Choriocarcinoma with uterine rupture in a patient with confirmed COVID-19 infection: A rare case report
T2  - International Journal of Cancer Management
TI  - Choriocarcinoma with uterine rupture in a patient with confirmed COVID-19 infection: A rare case report
UR  - https://ijcm.kowsarpub.com/cdn/dl/5cb501d2-ff65-11ea-b6f7-8b601073b998
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005153375
VL  - 13
ID  - 7782980
ER  - 

TY  - JOUR
AB  - BACKGROUND: Restricting community mobility during COVID-19 can potentially trigger anxiety, depression and stress in the community. The study aims to analyze variables associated with the community psychosocial burden (anxiety level) during the co-19 pandemic in Indonesia. METHODS: This study collected data (n = 8,031) online. Psychosocial burden was measured based on the anxiety level which include 5 aspects, such as economic, religious, educational, employment, and social issues. Each question used a Likert scale. Six independent were examined, such as age, gender, religion, marital, education, and employement. In the final stage, a multivariate test was performed using a multinomial logistic regression. RESULTS: Someone older experienced less high anxiety. The age group of 20-29 years was 4,330 times likely to experience higher anxiety than the age group of �?0 years. While, those in the age group of 40-49 years weer 2,322 times more likely to have higher anxiety than those in the age group of �?0 years. Male respondents had lower possibility of medium to high anxiety than females. Respondents with secondary and lower education had 3,117 times possibilities to experience higher anxiety than those with high education level. CONCLUSION: Four variables affected the psychosocial burden i.e, anxiety level of community in Indonesia. These involved age, gender, education, and employement.
AD  - Faculty of Public Health, Universitas Airlangga, Surabaya, Indonesia.
National Institute of Health Research and Development, The Indonesian Ministry of Health, Jakarta, Indonesia.
Faculty of Health, Nadlatul Ulama University, Surabaya, Indonesia.
The Indonesian Public Health Union, Makassar, Indonesia.
AN  - 33020744
AU  - Megatsari, H.
AU  - Laksono, A. D.
AU  - Ibad, M.
AU  - Herwanto, Y. T.
AU  - Sarweni, K. P.
AU  - Geno, R. A. P.
AU  - Nugraheni, E.
C1  - 10/6/2020
C2  - PMC7526603
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.heliyon.2020.e05136
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Heliyon
KW  - Covid-19
Health behaviour
Mental health
Psychology
Psychosocial burden
Public health
LA  - eng
N1  - Megatsari, Hario
Laksono, Agung Dwi
Ibad, Mursyidul
Herwanto, Yeni Tri
Sarweni, Kinanty Putri
Geno, Rachmad Ardiansyah Pua
Nugraheni, Estiningtyas
Journal Article
England
Heliyon. 2020 Sep 30;6(10):e05136. doi: 10.1016/j.heliyon.2020.e05136. eCollection 2020 Oct.
PY  - 2020
SN  - 2405-8440 (Print)
2405-8440
SP  - e05136
ST  - The community psychosocial burden during the COVID-19 pandemic in Indonesia
T2  - Heliyon
TI  - The community psychosocial burden during the COVID-19 pandemic in Indonesia
VL  - 6
ID  - 7784982
ER  - 

TY  - JOUR
AB  - Cancer patients frequently develop tumor and treatment-related complications, leading to diminished quality of life, shortened survival, and overutilization of emergency department and hospital services. Outpatient oncology treatment has potential to leave cancer patients unmonitored for long periods while at risk of clinical deterioration which has been exaggerated during the COVID19 pandemic. Visits to cancer clinics and hospitals risk exposing immunocompromised patients to infectious complications. Remote patient reported outcomes monitoring systems have been developed for use in cancer treatment, showing benefits in economic and survival outcomes. While advanced devices such as pulmonary artery pressure monitors and implantable loop recorders have proven benefits in cardiovascular care, similar options do not exist for oncology. Here we review the current literature around remote patient monitoring in cancer care and propose the use of reliable devices for capturing and reporting patient symptoms and physiology.
AD  - Oncology, Dana-Farber Cancer Institute, Boston, USA.
Oncology, West Cancer Center and Research Institute and the University of Tennessee Health Science Center, Memphis, USA.
Oncology, Stanford University School of Medicine, Palo Alto, USA.
Radiation Oncology, Northbay Healthcare, Vacaville, USA.
Oncology, Cedars-Sinai Medical Center, Los Angeles, USA.
AN  - 33014652
AU  - McGregor, B. A.
AU  - Vidal, G. A.
AU  - Shah, S. A.
AU  - Mitchell, J. D.
AU  - Hendifar, A. E.
C1  - 10/6/2020
C2  - PMC7526951
DA  - Aug 31
DB  - PubMed
DO  - 10.7759/cureus.10156
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Cureus
KW  - implantable medical device
oncology
patient reported outcomes
pro
remote monitoring
rpm
LA  - eng
N1  - 2168-8184
McGregor, Bradley A
Vidal, Gregory A
Shah, Sumit A
Mitchell, James D
Hendifar, Andrew E
Journal Article
Review
Cureus. 2020 Aug 31;12(8):e10156. doi: 10.7759/cureus.10156.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10156
ST  - Remote Oncology Care: Review of Current Technology and Future Directions
T2  - Cureus
TI  - Remote Oncology Care: Review of Current Technology and Future Directions
VL  - 12
ID  - 7785379
ER  - 

TY  - JOUR
AB  - In March 2020, Prime Minister Abe Shinzō, the Tokyo Olympic Organising Committee, and the International Olympic Committee postponed the 2020 Tokyo Olympics for one year. The delay is the most prominent consequence of the COVID-19 crisis in Japan thus far. But the “Corona Calamity�?(korona ka) is bigger than the Olympics. The totality of the disaster is impossible to capture. The very thing that makes it a calamity are the myriad rhythms of crisis that intersect at COVID-19. If there is a shared theme to be found in these rhythms, it is the question of recovery. When will it happen? What will it look like? And what, exactly, will we recover? In what follows, I share three rhythms of crisis and recovery: national history, the tourism industry, and the parcel delivery industry.
AD  - Kate McDonald ( kmcdonald@history.ucsb.edu ) is Associate Professor of History at the University of California, Santa Barbara ; Kate McDonald ( kmcdonald@history.ucsb.edu ) is Associate Professor of History at the University of California, Santa Barbara
AN  - 2448352106
AU  - McDonald, Kate
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1017/S0021911820002296
DP  - ProQuest Central
IS  - 3
KW  - Literature
Olympics
Japan
COVID-19
2011 Triple Disaster
parcel delivery
tourism
Abenomics
cultural diplomacy
national disaster
recovery
Aircraft accidents & safety
Olympic games
Tsunamis
Disasters
Coronaviruses
Rhythm
Nuclear power plants
Crises
Disease transmission
LA  - English
N1  - Copyright - Copyright © The Association for Asian Studies, Inc., 2020
SubjectsTermNotLitGenreText - Japan
PY  - 2020
SN  - 00219118
SP  - 599-608
ST  - Olympic Recoveries
T2  - Journal of Asian Studies
TI  - Olympic Recoveries
UR  - https://www.proquest.com/docview/2448352106?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Olympic+Recoveries&title=The+Journal+of+Asian+Studies&issn=00219118&date=2020-08-01&volume=79&issue=3&spage=599&au=McDonald%2C+Kate&isbn=&jtitle=The+Journal+of+Asian+Studies&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1017%2FS0021911820002296
VL  - 79
ID  - 7784921
ER  - 

TY  - JOUR
AB  - On February 20, 2020 the first case of coronavirus disease (COVID-19) has been diagnosed in Italy. In a few weeks the Policlinico A. Gemelli Hospital in Rome has become a so called "COVID Hospital", so its structure has changed and consequently also the organization of the clinical activities of the Psychiatric Unit. In particular, outpatients' services (ambulatory and day hospital) have guaranteed the management of emergencies, the administration of oral and long acting drug therapies, the assistance of patients with severe mental illness by means of telephone checks.
AD  - Institute of Psychiatry and Psychology, Department of Geriatrics, Neuroscience and Orthopedics, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
AN  - 33012116
AU  - Mazza, M.
AU  - Marano, G.
AU  - Janiri, L.
AU  - Sani, G.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/bdi.13015
DP  - NLM
ET  - 2020/10/05
J2  - Bipolar disorders
KW  - Bipolar Disorder
Covid-19
personalized medicine
LA  - eng
N1  - 1399-5618
Mazza, Marianna
Orcid: 0000-0002-3007-8162
Marano, Giuseppe
Janiri, Luigi
Sani, Gabriele
Letter
Denmark
Bipolar Disord. 2020 Oct 4. doi: 10.1111/bdi.13015.
PY  - 2020
SN  - 1398-5647
ST  - MANAGING bipolar disorder patients during COVID-19 outbreak
T2  - Bipolar disorders
TI  - MANAGING bipolar disorder patients during COVID-19 outbreak
ID  - 7785619
ER  - 

TY  - JOUR
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Modena, Via Largo del Pozzo 71, Modena, Italy.
Bronchoscopy and Respiratory Diseases Department, University Hospital of Modena, Via Largo del Pozzo 71, Modena, Italy.
Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital of Modena, Via Largo del Pozzo 71, Modena, Italy. matteo.fermi.med@gmail.com.
AN  - 33011955
AU  - Mattioli, F.
AU  - Marchioni, A.
AU  - Andreani, A.
AU  - Cappiello, G.
AU  - Fermi, M.
AU  - Presutti, L.
C1  - 10/6/2020
C2  - PMC7532739
DA  - Oct 3
DB  - PubMed
DO  - 10.1007/s00405-020-06394-w
DP  - NLM
ET  - 2020/10/05
J2  - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
LA  - eng
N1  - 1434-4726
Mattioli, Francesco
Orcid: 0000-0002-1481-668x
Marchioni, Alessandro
Orcid: 0000-0003-3720-3517
Andreani, Alessandro
Cappiello, Gaia
Fermi, Matteo
Orcid: 0000-0002-2727-0321
Presutti, Livio
Orcid: 0000-0002-2752-132x
Letter
Eur Arch Otorhinolaryngol. 2020 Oct 3:1-2. doi: 10.1007/s00405-020-06394-w.
PY  - 2020
SN  - 0937-4477 (Print)
0937-4477
SP  - 1-2
ST  - Post-intubation tracheal stenosis in COVID-19 patients
T2  - European archives of oto-rhino-laryngology : official journal of European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
TI  - Post-intubation tracheal stenosis in COVID-19 patients
ID  - 7785640
ER  - 

TY  - JOUR
AB  - Once the WHO declared the Sars-CoV-2 pandemic, the world had to reprogram numerous clinical activities, particularly those related to highly disabling diseases such as inflammatory bowel diseases (IBDs). In this study, 1083 IBD patients were assessed, affected by Crohn's Disease (CD) and Ulcerative Colitis (UC), and subdivided into two groups. The first group included patients who needed treatment in person at the outpatients clinic, while the second group could be tele-monitored because they were able to self-administer therapy. The tele-monitoring was based on telecommunication applications via smartphone, driven by a dedicated clinical control room in the IBD Clinic. The aim of this study was to assess the quality of life (using IBDQ32) of UC patients and tele-monitored CD patients (tele-monitoring group) as compared to those patients who underwent assessment in person in the outpatients clinic (control group). Despite observing a lower number of relapses in the control group than the tele-monitoring group, there were no statistically significant differences between the groups in terms of the IBD32Q scores. Tele-monitoring of patients who are able to self-administer the IBD therapy can be an effective vicarious system as compared to the clinical evaluation in person, that could lead to important changes to avoid the overcrowding of the IBD outpatients clinic, especially during public health crises like the present pandemic.
AD  - National Institute of Gastroenterology, "Saverio de Bellis" Research Hospital, 70013 Castellana Grotte, Italy.
AN  - 33019563
AU  - Mastronardi, M.
AU  - Curlo, M.
AU  - Polignano, M.
AU  - Vena, N.
AU  - Rossi, D.
AU  - Giannelli, G.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/healthcare8040377
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Healthcare (Basel, Switzerland)
KW  - Crohn’s Disease (CD)
Ulcerative Colitis (UC)
inflammatory bowel disease (IBD)
smart phone
tele-monitoring
LA  - eng
N1  - Mastronardi, Mauro
Curlo, Margherita
Polignano, Maurizio
Vena, Natalino
Rossi, Daniela
Giannelli, Gianluigi
Journal Article
Switzerland
Healthcare (Basel). 2020 Oct 1;8(4):E377. doi: 10.3390/healthcare8040377.
PY  - 2020
SN  - 2227-9032 (Print)
2227-9032
ST  - Remote Monitoring Empowerment of Patients with IBDs during the SARS-CoV-2 Pandemic
T2  - Healthcare (Basel, Switzerland)
TI  - Remote Monitoring Empowerment of Patients with IBDs during the SARS-CoV-2 Pandemic
VL  - 8
ID  - 7785097
ER  - 

TY  - JOUR
AB  - PURPOSE: Unidentified dynamics for the causative agent of COVID-19, SARS-Cov-2, led to the critical public health issue. Suspicion for the airborne potential of SARS-Cov-2 is an important problem for its transmission and relevant epidemics. This research investigated hospital indoor air quality to SARS-Cov-2 occurrence and determination its air born potential. METHODS: The site study was a referral hospital with 630 beds for admitting of COVID-19 patients. Air sampling was done (n�?�?1) on selected wards including Emergency 1, Emergency 2, bedridden (4-B, 10-D), ICU 2, ICU 3, CT-SCAN, and laundry. The average temperature and relative humidities were 22 ±�? ��C and 43 percent respectively. All glass impinger used for sampling in which the sampling pumps capacities were 5 and 40 L.min(-�?). Sampling duration time was 20 and 15 minutes and 100 to 1000 L of air were gathered. All parts of the sampling equipment were completely disinfected by hot water, ethanol (70%), chlorine solution (1000 ppm), hot water (70 ��C for 1 min) and washed with distilled water. The transmitting media (7 ml) was injected into impinger and residual of this media (2 ml) was sent to the virology laboratory within 2 hours and preserved on refrigerator �? ��C. Analysis of samples was performed by RT-PCR and repeated for accuracy control. RESULTS: All of the samples were negative for SARS-Cov-2 occurrence. These results showed that SARS-Cov-2 had not airborne potential in this hospital. CONCLUSIONS: Although SARS-Cov-2 similar to the SARS virus but, SARS-Cov-2 is not an airborne virus.
AD  - Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. GRID: grid.411521.2. ISNI: 0000 0000 9975 294X
Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. GRID: grid.411521.2. ISNI: 0000 0000 9975 294X
Students' Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran. GRID: grid.411521.2. ISNI: 0000 0000 9975 294X
Trauma Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. GRID: grid.411521.2. ISNI: 0000 0000 9975 294X
Trauma Research Center, Emergency Deptment, Baqiyatallah University of Medical Sciences, Tehran, Iran. GRID: grid.411521.2. ISNI: 0000 0000 9975 294X
Applied Virology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. GRID: grid.411521.2. ISNI: 0000 0000 9975 294X
AN  - 33014385
AU  - Masoumbeigi, H.
AU  - Ghanizadeh, G.
AU  - Yousefi Arfaei, R.
AU  - Heydari, S.
AU  - Goodarzi, H.
AU  - Dorostkar Sari, R.
AU  - Tat, M.
C1  - 10/6/2020
C2  - PMC7525766
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s40201-020-00543-3
DP  - NLM
ET  - 2020/10/06
J2  - Journal of environmental health science & engineering
KW  - Airborne
Covid-19
Hospital
Indoor air quality
SARS-Cov-2
LA  - eng
N1  - 2052-336x
Masoumbeigi, Hossein
Ghanizadeh, Ghader
Orcid: 0000-0002-5624-4712
Yousefi Arfaei, Reza
Heydari, Soleyman
Goodarzi, Hassan
Dorostkar Sari, Ruhollah
Tat, Mehdi
Journal Article
J Environ Health Sci Eng. 2020 Sep 30:1-5. doi: 10.1007/s40201-020-00543-3.
PY  - 2020
SN  - 2052-336X (Print)
SP  - 1-5
ST  - Investigation of hospital indoor air quality for the presence of SARS-Cov-2
T2  - Journal of environmental health science & engineering
TI  - Investigation of hospital indoor air quality for the presence of SARS-Cov-2
ID  - 7785398
ER  - 

TY  - JOUR
AD  - Servicio de Medicina Interna, Hospital Universitari Parc Taul�T, Sabadell, Barcelona, España.
Servicio de Neurolog�Ta, Hospital Universitari Parc Taul�T, Sabadell, Barcelona, España.
Servicio de Enfermedades Infecciosas, Hospital Universitari Parc Taul�T, Sabadell, Barcelona, España.
Unidad de Geriatr�Ta de Agudos y Paciente Cr�Qnico Complejo, Hospital Universitari Parc Taul�T, Sabadell, Barcelona, España. Electronic address: mmorenoar@tauli.cat.
AN  - 33020016
AU  - Mas Maresma, L.
AU  - Barrachina Esteve, O.
AU  - Navarro Vilasar�Q, M.
AU  - Moreno-Ariño, M.
C1  - 10/6/2020
DA  - Sep 11
DB  - PubMed
DO  - 10.1016/j.regg.2020.08.004
DP  - NLM
ET  - 2020/10/07
J2  - Revista espanola de geriatria y gerontologia
LA  - spa
N1  - 1578-1747
Mas Maresma, Laia
Barrachina Esteve, Oriol
Navarro Vilasar�Q, Marta
Moreno-Ariño, Marc
Case Reports
Spain
Rev Esp Geriatr Gerontol. 2020 Sep 11:S0211-139X(20)30142-6. doi: 10.1016/j.regg.2020.08.004.
OP  - Miastenia gravis asociada a la infecci�Qn por SARS-CoV-2: una conjunci�Qn de factores.
PY  - 2020
SN  - 0211-139x
ST  - [Myasthenia gravis associated with SARS-CoV-2 infection: a conjunction of several factors]
T2  - Revista espanola de geriatria y gerontologia
TI  - [Myasthenia gravis associated with SARS-CoV-2 infection: a conjunction of several factors]
ID  - 7785060
ER  - 

TY  - JOUR
AD  - Investigative Pathology Laboratory, Federal University of Sergipe, Aracaju, Brazil.
Graduate Program in Law, Federal University of Sergipe, Aracaju, Brazil.
Juvenile Justice and Child Abuse, UNICEF, Aracaju, Brazil.
AN  - 33012011
AU  - Martins-Filho, P. R.
AU  - Damascena, N. P.
AU  - Lage, R. C.
AU  - Sposato, K. B.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/jpc.15213
DP  - NLM
ET  - 2020/10/05
J2  - Journal of paediatrics and child health
LA  - eng
N1  - 1440-1754
Martins-Filho, Paulo R
Orcid: 0000-0001-8779-0727
Damascena, Nicole P
Lage, Renata Cm
Sposato, Karyna B
Journal Article
Australia
J Paediatr Child Health. 2020 Oct 4. doi: 10.1111/jpc.15213.
PY  - 2020
SN  - 1034-4810
ST  - Decrease in child abuse notifications during COVID-19 outbreak: A reason for worry or celebration?
T2  - Journal of paediatrics and child health
TI  - Decrease in child abuse notifications during COVID-19 outbreak: A reason for worry or celebration?
ID  - 7785631
ER  - 

TY  - JOUR
AB  - BACKGROUND: To evaluate chest-computed-tomography (CT) scans in coronavirus-disease-2019 (COVID-19) patients for signs of organizing pneumonia (OP) and microinfarction as surrogate for microscopic thromboembolic events. METHODS: Real-time polymerase-chain-reaction (RT-PCR)-confirmed COVID-19 patients undergoing chest-CT (non-enhanced, enhanced, pulmonary-angiography [CT-PA]) from March-April 2020 were retrospectively included (COVID-19-cohort). As control-groups served 175 patients from 2020 (cohort-2020) and 157 patients from 2019 (cohort-2019) undergoing CT-PA for pulmonary embolism (PE) during the respective time frame at our institution. Two independent readers assessed for presence and location of PE in all three cohorts. In COVID-19 patients additionally parenchymal changes typical of COVID-19 pneumonia, infarct pneumonia and OP were assessed. Inter-reader agreement and prevalence of PE in different cohorts were calculated. RESULTS: From 68 COVID-19 patients (42 female [61.8%], median age 59 years [range 32-89]) undergoing chest-CT 38 obtained CT-PA. Inter-reader-agreement was good (k = 0.781). On CT-PA, 13.2% of COVID-19 patients presented with PE whereas in the control-groups prevalence of PE was 9.1% and 8.9%, respectively (p = 0.452). Up to 50% of COVID-19 patients showed changes typical for OP. 21.1% of COVID-19 patients suspected with PE showed subpleural wedge-shaped consolidation resembling infarct pneumonia, while only 13.2% showed visible filling defects of the pulmonary artery branches on CT-PA. CONCLUSION: Despite the reported hypercoagulability in critically ill patients with COVID-19, we did not encounter higher prevalence of PE in our patient cohort compared to the control cohorts. However, patients with suspected PE showed a higher prevalence of lung changes, resembling patterns of infarct pneumonia or OP and CT-signs of pulmonary-artery hypertension.
AD  - Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Zurich, Switzerland.
Faculty of Medicine, University of Zurich, Zurich, Switzerland.
Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland.
AN  - 33017451
AU  - Martini, K.
AU  - Blüthgen, C.
AU  - Walter, J. E.
AU  - Nguyen-Kim, T. D. L.
AU  - Thienemann, F.
AU  - Frauenfelder, T.
C1  - 10/6/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240078
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Martini, Katharina
Orcid: 0000-0002-2638-6832
Blüthgen, Christian
Orcid: 0000-0001-7321-5676
Walter, Joan Elias
Nguyen-Kim, Thi Dan Linh
Thienemann, Friedrich
Orcid: 0000-0002-4801-2030
Frauenfelder, Thomas
Orcid: 0000-0002-3295-6619
Journal Article
United States
PLoS One. 2020 Oct 5;15(10):e0240078. doi: 10.1371/journal.pone.0240078. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240078
ST  - Patterns of organizing pneumonia and microinfarcts as surrogate for endothelial disruption and microangiopathic thromboembolic events in patients with coronavirus disease 2019
T2  - PloS one
TI  - Patterns of organizing pneumonia and microinfarcts as surrogate for endothelial disruption and microangiopathic thromboembolic events in patients with coronavirus disease 2019
VL  - 15
ID  - 7785134
ER  - 

TY  - JOUR
AB  - While institutional repositories are common in medical schools and academic health centers, they have been used by only a small number of health systems to track and promote their research and scholarly activity. This article describes how Providence System Library Services leveraged their existing institutional repository platform to substitute a virtual showcase for an annual in-person event.
AD  - Heather.Martin@Providence.org, Director, System Library Services, Providence St. Joseph Health, Portland, OR.
amanda.schwartz@providence.org, Digital Asset Librarian, System Library Services, Providence St. Joseph Health, Missoula, MT.
AN  - 33013224
AU  - Martin, H. J.
AU  - Schwartz, A.
C1  - 10/6/2020
C2  - PMC7524618
DA  - Oct 1
DB  - PubMed
DO  - 10.5195/jmla.2020.1052
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Journal of the Medical Library Association : JMLA
LA  - eng
N1  - 1558-9439
Martin, Heather J
Orcid: 0000-0002-2633-096x
Schwartz, Amanda
Journal Article
J Med Libr Assoc. 2020 Oct 1;108(4):645-646. doi: 10.5195/jmla.2020.1052.
PY  - 2020
SN  - 1536-5050 (Print)
1536-5050
SP  - 645-646
ST  - Virtual resident showcase: leveraging an institutional repository during COVID-19 social distancing
T2  - Journal of Medical Library Association : JMLA
TI  - Virtual resident showcase: leveraging an institutional repository during COVID-19 social distancing
VL  - 108
ID  - 7785481
ER  - 

TY  - JOUR
AD  - Antimicrobial Resistance and Infection Control Division of HPSC, 25-27 Middle Gardiner Street, Dublin 1, Ireland.
Department of Infectious Diseases, St James's Hospital, James's Street, Dublin 8, Ireland.
School of Medicine, Trinity College Dublin, College Green, Dublin 2, Ireland.
Department of Clinical Microbiology, Our Lady of Lourdes Hospital, Drogheda, Co. Louth, Ireland.
Department of Microbiology, Beaumont Hospital, Dublin, Ireland.
Department of Clinical Microbiology, Royal College of Surgeons Ireland, Dublin, Ireland.
AN  - 33011763
AU  - Martin, E.
AU  - Philbin, M.
AU  - Hughes, G.
AU  - Bergin, C.
AU  - Talento, A. F.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1093/jac/dkaa400
DP  - NLM
ET  - 2020/10/05
J2  - The Journal of antimicrobial chemotherapy
LA  - eng
N1  - 1460-2091
Martin, Ellen
Philbin, Marie
Hughes, Gerry
Bergin, Colm
Talento, Alida Fe
Journal Article
England
J Antimicrob Chemother. 2020 Oct 4:dkaa400. doi: 10.1093/jac/dkaa400.
PY  - 2020
SN  - 0305-7453
ST  - Antimicrobial stewardship challenges and innovative initiatives in the acute hospital setting during the COVID-19 pandemic
T2  - Journal of antimicrobial chemotherapy
TI  - Antimicrobial stewardship challenges and innovative initiatives in the acute hospital setting during the COVID-19 pandemic
ID  - 7785655
ER  - 

TY  - JOUR
AU  - Marjerison, Rob Kim
AU  - Rahman, Jahidur Md
AU  - Li, Zihui
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
PY  - 2020
ST  - Students�?Attitudes Towards Distance Education: A Comparative Study between Sino-Foreign Cooperative Universities and Typical Universities in China (preprint)
T2  - SSRN
TI  - Students�?Attitudes Towards Distance Education: A Comparative Study between Sino-Foreign Cooperative Universities and Typical Universities in China (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693978
ID  - 7788903
ER  - 

TY  - JOUR
AN  - 33016684
AU  - Marcinkiewicz, J.
AU  - Mazurek, H.
AU  - Majka, G.
AU  - Chain, B.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.20452/pamw.15630
DP  - NLM
ET  - 2020/10/06
J2  - Polish archives of internal medicine
LA  - eng
N1  - 1897-9483
Marcinkiewicz, Janusz
Mazurek, Henryk
Majka, Grzegorz
Chain, Benjamin
Journal Article
Poland
Pol Arch Intern Med. 2020 Oct 5. doi: 10.20452/pamw.15630.
PY  - 2020
SN  - 0032-3772
ST  - Are patients with lung cystic fibrosis at increased risk for severe and fatal COVID-19? Interleukin-6 as a predictor of COVID-19 outcome
T2  - Polish archives of internal medicine
TI  - Are patients with lung cystic fibrosis at increased risk for severe and fatal COVID-19? Interleukin-6 as a predictor of COVID-19 outcome
ID  - 7785183
ER  - 

TY  - JOUR
AB  - Despite the fact that strand-displacing activity is of great utility for a variety of applications, including isothermal amplification assays, there are relatively few strand-displacing DNA polymerases. In particular, the thermotolerant DNA polymerase from Geobacillus stearothermophilus (previously Bacillus stearothermophilus), Bst DNA polymerase (Bst DNAP), is used in a variety of assays, including loop-mediated isothermal amplification. However, despite its wide use, its properties remain open to improvement, as has been demonstrated by a variety of engineering efforts, including the identification of point mutations that impact its robustness, strand-displacement capabilities, and nascent reverse transcriptase activity. Interestingly, a strategy that has been commonly used to alter the capabilities of DNA polymerases, the addition of additional DNA- or RNA-binding domains, has yet to be applied to Bst DNAP. To this end, we now show that by adding fusion domains the performance of Bst DNAP in isothermal amplification assays, including its nascent RT activity, can be greatly improved. The impact of these improvements on the development of LAMP assays for the detection of SARS-CoV-2 is fully explored.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by the National Institutes of Health and the National Science Foundation.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No human subject studies were performed in this study. This study was performed under approval from the University of Texas at Austin IRB for the study number UT IRB # 2020-07-0011. All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data pertaining to the study have been provided in the manuscript.
AU  - Maranhao, Andre
AU  - Bhadra, Sanchita
AU  - Paik, Inyup
AU  - Walker, David
AU  - Ellington, Andrew D.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20203356
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20203356
ST  - An improved and readily available version of Bst DNA Polymerase for LAMP, and applications to COVID-19 diagnostics (preprint)
T2  - medRxiv
TI  - An improved and readily available version of Bst DNA Polymerase for LAMP, and applications to COVID-19 diagnostics (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20203356.abstract
ID  - 7788870
ER  - 

TY  - JOUR
AB  - A sizeable proportion of individuals contracting the corona virus disease 2019 (COVID-19) infection remains asymptomatic, while some patients develop mild symptoms and others exhibit severe symptomatology becoming critically ill necessitating admission to intensive care unit exposed to a high mortality risk. The pathophysiological mechanisms underlying this diversity in the clinical picture of COVID-19 are poorly understood. A variety of reasons have been postulated, among which, viral load, age, gender, immune response, blood type, genotypes, polymorphisms, comorbidities and pre-existing immunity are actively explored. Thus, there is a dire need to further elucidate this phenomenon and find ways to identify and discern susceptible from resistant individuals with the ultimate goal to find a cure for the disease. These issues are herein discussed and pertinent recent literature is reviewed. [ABSTRACT FROM AUTHOR]
Copyright of Rhythmos is the property of Evagelismos General Hospital of Athens and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146201706
AU  - Manolis, Antonis S.
AU  - Manolis, Theodora A.
C1  - 10/6/2020
DB  - a9h
DP  - EBSCOhost
IS  - 4
KW  - ACE2
asymptomatic COVID-19
blood type
children
COVID-19
genetics
immune response
immunity
polymorphism
SARS-CoV-2
transmissibility
vitamin
M3  - Article
N1  - Manolis, Antonis S. 1; Email Address: asm@otenet.gr Manolis, Theodora A. 2; Affiliation: 1: Athens University School of Medicine, Athens, Greece 2: Red Cross Hospital, Athens, Greece; Source Info: Oct2020, Vol. 15 Issue 4, p65; Author-Supplied Keyword: ACE2; Author-Supplied Keyword: asymptomatic COVID-19; Author-Supplied Keyword: blood type; Author-Supplied Keyword: children; Author-Supplied Keyword: COVID-19; Author-Supplied Keyword: genetics; Author-Supplied Keyword: immune response; Author-Supplied Keyword: immunity; Author-Supplied Keyword: polymorphism; Author-Supplied Keyword: SARS-CoV-2; Author-Supplied Keyword: transmissibility; Author-Supplied Keyword: vitamin; Number of Pages: 8p; Document Type: Article
PY  - 2020
SN  - 17927919
SP  - 65-72
ST  - Asymptomatic Carriers/Patients with COVID-19 Infection: How is this Possible?
T2  - Rhythmos
TI  - Asymptomatic Carriers/Patients with COVID-19 Infection: How is this Possible?
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146201706&site=ehost-live
VL  - 15
ID  - 7783630
ER  - 

TY  - JOUR
AB  - The SARS-CoV-2 (COVID-19) pandemic has significantly impacted the management of patients with gynecologic cancers. Many centers have reduced access to routine visits to avoid crowded waiting areas and specially to reduce the infection risk for oncologic patients. The goal of this review is to propose a surveillance algorithm for patients with gynecologic cancers during the COVID-19 pandemic based on existing evidence and established guidelines. It is time to consider strategies based on telemedicine and to adapt protocols in this new era. We hereby propose a strategy for routine surveillance both during and beyond the pandemic.
AD  - Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain GMancebo@parcdesalutmar.cat.
Department of Obstetrics and Gynecology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Radiation Oncology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Medical Oncology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
Department of Pathology, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona, Spain.
AN  - 33020205
AU  - Mancebo, G.
AU  - Solé-Sedeño, J. M.
AU  - Membrive, I.
AU  - Taus, A.
AU  - Castells, M.
AU  - Serrano, L.
AU  - Carreras, R.
AU  - Miralpeix, E.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/ijgc-2020-001942
DP  - NLM
ET  - 2020/10/07
J2  - International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
KW  - cervical cancer
endometrial neoplasms
gynecology
ovarian cancer
LA  - eng
N1  - 1525-1438
Mancebo, Gemma
Orcid: 0000-0001-5859-7936
Solé-Sedeño, Josep-Maria
Membrive, Ismael
Taus, Alvaro
Castells, Marta
Serrano, Laia
Carreras, Ramon
Miralpeix, Ester
Orcid: 0000-0003-1708-6448
Journal Article
Review
England
Int J Gynecol Cancer. 2020 Oct 5:ijgc-2020-001942. doi: 10.1136/ijgc-2020-001942.
PY  - 2020
SN  - 1048-891x
ST  - Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19)
T2  - International journal of gynecological cancer : official journal of International Gynecological Cancer Society
TI  - Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19)
ID  - 7785044
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To describe lifestyle changes with regard to consumption of tobacco and alcohol, food intake and physical activity, in the period of social restriction resulting from the COVID-19 pandemic. METHODS: This is a cross-sectional study conducted in Brazil with data from the ConVid online health behavior survey. The data were collected via an online questionnaire answered by the survey participants. Post-stratification procedures were used to calculate prevalence rates and 95% confidence intervals. RESULTS: 45,161 individuals aged 18 years or more participated. During the period of social restriction participants reported a decrease in practicing physical activity and an increase in time spent using computers or tablets or watching TV, intake of ultra-processed foods, number of cigarettes smoked and alcoholic beverage consumption. Differences were observed according to sex and age group. CONCLUSION: The results indicate a worsening of lifestyles and an increase in health risk behaviors.
AU  - Malta, Deborah Carvalho
AU  - Szwarcwald, Célia Landmann
AU  - Barros, Marilisa Berti de Azevedo
AU  - Gomes, Crizian Saar
AU  - Machado, Ísis Eloah
AU  - Souza Júnior, Paulo Roberto Borges de
AU  - Romero, Dalia Elena
AU  - Lima, Margareth Guimaraes
AU  - Damacena, Giseli Nogueira
AU  - Pina, Maria de F֙tima
AU  - Freitas, Maria Imaculada de F֙tima
AU  - Werneck, André Oliveira
AU  - Silva, Danilo Rodrigues Pereira da
AU  - Azevedo, Luiz Ot֙vio
AU  - Gracie, Renata
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 4
LA  - pt
PY  - 2020
SP  - e2020407-e2020407
ST  - A pandemia da COVID-19 e as mudanças no estilo de vida dos brasileiros adultos: um estudo transversal, 2020
T2  - Epidemiol Serv Saude
TI  - A pandemia da COVID-19 e as mudanças no estilo de vida dos brasileiros adultos: um estudo transversal, 2020
TT  - A pandemia da COVID-19 e as mudanças no estilo de vida dos brasileiros adultos: um estudo transversal, 2020.
The COVID-19 Pandemic and changes in adult Brazilian lifestyles: a cross-sectional study, 2020.
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-810135
VL  - 29
ID  - 7788744
ER  - 

TY  - JOUR
AB  - [This corrects the article DOI: 10.1007/s10640-020-00488-z.].
AD  - OFCE - French Economic Observatory, Paris, France.
NEO - Netherlands Economic Observatory, Rotterdam, The Netherlands.
TNO - Netherlands Organization for Applied Scientifc Research, The Hague, The Netherlands.
LSE - London School of Economics, London, UK. GRID: grid.13063.37. ISNI: 0000 0001 0789 5319
AN  - 33020682
AU  - Malliet, P.
AU  - Reyn؈s, F.
AU  - Landa, G.
AU  - Hamdi-Cherif, M.
AU  - Saussay, A.
C1  - 10/6/2020
C2  - PMC7527785
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s10640-020-00510-4
DP  - NLM
ET  - 2020/10/07
J2  - Environmental & resource economics
LA  - eng
N1  - Malliet, Paul
Orcid: 0000-0003-0362-9050
Reyn؈s, Frédéric
Landa, Gissela
Hamdi-Cherif, Meriem
Saussay, Aurélien
Published Erratum
Netherlands
Environ Resour Econ (Dordr). 2020 Oct 1:1. doi: 10.1007/s10640-020-00510-4.
PY  - 2020
SN  - 0924-6460 (Print)
0924-6460
SP  - 1
ST  - Correction to: Assessing Short-Term and Long-Term Economic and Environmental Effects of the COVID-19 Crisis in France
T2  - Environmental & resource economics
TI  - Correction to: Assessing Short-Term and Long-Term Economic and Environmental Effects of the COVID-19 Crisis in France
ID  - 7785011
ER  - 

TY  - JOUR
AB  - As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intravenous vitamin C for severe COVID-19 infection. Collapsing FSGS has been described in patients with COVID-19 infection associated with APOL-1; however, this case had collapsing FSGS developing in low-risk heterozygous APOL-1 variant, and we postulate that the intensity of the COVID-19 cytokine storm overwhelmed the protective state of APOL-1 heterozygosity. This case illustrates the importance of assessing the risk and benefit of planned therapeutic interventions on a case-by-case basis especially when there are still so many unknowns in the management of COVID-19 infection. Strong consideration should be given for performing a renal biopsy in patients who develop multifactorial acute kidney injury.
AD  - Eastern Virginia Medical School, Norfolk, VA, USA.
Sentara Norfolk General Hospital, Norfolk, VA, USA.
AN  - 33019829
AU  - Malhotra, V.
AU  - Magoon, S.
AU  - Troyer, D. A.
AU  - McCune, T. R.
C1  - 10/6/2020
DA  - Jan-Dec
DB  - PubMed
DO  - 10.1177/2324709620963635
DP  - NLM
ET  - 2020/10/07
J2  - Journal of investigative medicine high impact case reports
KW  - Aki
Covid
Fsgs
Sars
collapsing
glomerulopathy
oxalate
LA  - eng
N1  - 2324-7096
Malhotra, Varun
Magoon, Sandeep
Troyer, Dean A
Orcid: 0000-0002-0337-5890
McCune, Thomas R
Journal Article
United States
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620963635. doi: 10.1177/2324709620963635.
PY  - 2020
SN  - 2324-7096
SP  - 2324709620963635
ST  - Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy
T2  - Journal of investigative medicine high impact case reports
TI  - Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy
VL  - 8
ID  - 7785085
ER  - 

TY  - JOUR
AB  - BACKGROUND: The COVID-19 pandemic has made a significant impact on all spheres of society. The objective of this study was to examine the impact of COVID-19 on the practices, finances, and social aspects of Brazilian vascular surgeons' lives. METHODS: This is a descriptive analysis of the responses from Brazilian vascular surgeons to the cross-sectional anonymous Society for Vascular Surgery Wellness Task Force Pandemic Practice, Anxiety, Coping, and Support Survey for Vascular Surgeons disseminated 14-24 April 2020. Survey dissemination in Brazil occurred mainly via the Brazilian Society of Angiology and Vascular Surgery (SBACV) and social media. The survey evaluated the impact of the COVID-19 pandemic on vascular surgeons' lives by assessing COVID-19-related stressors, anxiety using theGeneral Anxiety Disorder (GAD)-7 scale, and coping strategies using the Brief Coping Orientation to Problems Experienced (Brief-COPE) inventory. RESULTS: A total of 452 responses were recorded from Brazil, with 335 (74%) respondents completing the entire survey. The majority of respondents were males (N�?�?01, 67%) and practiced in an urban hospitals. The majority of respondents considered themselves at high risk to be infected with COVID-19 (N�?�?51, 55.8%), and just over half the respondents noted that they had adequate PPE at their primary hospital (N�?�?71, 54%). One hundred and nine (35%) surgeons confirmed that their hospitals followed professional surgical society guidelines for prioritizing surgeries during the pandemic. At the time of the survey, only 33 (10%) surgeons stated they have pre-operative testing of patients for COVID-19 available at their hospital. Academic vascular surgeons reported being redeployed more often to help with other non-vascular duties compared to community-based or solo practitioners (43% vs. 30% vs. 21% respectively, P�?�?01). Severe anxiety due to pandemic-related financial concerns was similar in those surgeons practicing solo compared to those in community- or academic-based/group practice (46% vs. 38% vs. 22%; P�?�?54). The respondents reported their anxiety levels as mild based on the stressors investigated instead of moderate-severe (54% vs. 46%; P�?�?04). Social media was utilized heavily during the pandemic, with video gatherings being the most commonly used tool (76%). Self-distraction (60%) and situational acceptance (81%) were the most frequently reported coping mechanisms used among Brazilian vascular surgeons. CONCLUSION: The COVID pandemic has greatly affected healthcare providers around the world. At the time of this survey, Brazilian vascular surgeons are reporting low anxiety levels during this time and are using mostly active coping mechanisms.
AD  - Anschutz Medical Center, Division of Vascular Surgery and Endovascular Therapy, The University of Colorado, Aurora, CO, USA.
Division of Vascular Surgery, Botucatu School of Medicine, Sao Paulo State University, Botucatu, Brazil.
Vascular & Endovascular Surgery, McLaren Health System, Bay City, MI, USA.
New York/Presbyterian Weill Cornell School of Medicine, New York, NY, USA.
Department of Cardiovascular Surgery, University of Texas at Houston, Houston, TX, USA.
Vascular Surgery, Spectrum Health Medical Group, Grand Rapids, MI, USA.
Department of Surgery, University of Michigan, Ann Arbor, MI, USA.
Division of Vascular and Endovascular Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Division of Vascular Surgery. University of California Los Angeles, Los Angeles, CA, USA.
Division of Vascular Surgery, Department of Surgery, University of Washington, Seattle, WA, USA.
AN  - 33019914
AU  - Malgor, R. D.
AU  - Sobreira, M. L.
AU  - Mouawad, N. J.
AU  - Johnson, A. P.
AU  - Wohlauer, M. V.
AU  - Coogan, S. M.
AU  - Cuff, R. F.
AU  - Coleman, D. M.
AU  - Sheahan, M. G., 3rd
AU  - Woo, K.
AU  - Shalhub, S.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1177/1708538120954961
DP  - NLM
ET  - 2020/10/07
J2  - Vascular
KW  - Covid-19
Gad-7
brief COPE
vascular surgery practice
LA  - eng
N1  - 1708-539x
Malgor, Rafael D
Sobreira, Marcone Lima
Orcid: 0000-0003-2271-5878
Mouawad, Nicolas J
Orcid: 0000-0002-8699-0572
Johnson, Adam P
Wohlauer, Max V
Coogan, Sheila M
Cuff, Robert F
Coleman, Dawn M
Sheahan, Malachi G 3rd
Woo, Karen
Shalhub, Sherene
Journal Article
England
Vascular. 2020 Oct 6:1708538120954961. doi: 10.1177/1708538120954961.
PY  - 2020
SN  - 1708-5381
SP  - 1708538120954961
ST  - Brazilian vascular surgeons experience during the coronavirus (COVID-19) pandemic
T2  - Vascular
TI  - Brazilian vascular surgeons experience during the coronavirus (COVID-19) pandemic
ID  - 7785074
ER  - 

TY  - JOUR
AB  - This article is about a known case of heart failure presented with acute liver failure following a coronavirus disease-2019 (COVID-19) respiratory tract infection. The patient was admitted with encephalopathy and respiratory distress with a positive COVID-19 reverse transcription-polymerase chain reaction (RT-PCR) test. Elevated liver enzymes, severe coagulopathy, and hypoglycemia were apparent without any clinical or laboratory findings of sepsis, acute viral hepatitis, medicine related or drug-induced, or autoimmune-related acute liver failure. Supportive and therapeutic measures related to his cardiovascular, respiratory, and liver function were executed in the ICU. Unfortunately, the patient expired because of respiratory failure.
AD  - Anesthesiology and Critical Care, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IRN.
Cardiology, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, IRN.
AN  - 33014641
AU  - Makarem, J.
AU  - Naghibi, N.
AU  - Beigmohammadi, M. T.
AU  - Foroumandi, M.
AU  - Mehrpooya, M.
C1  - 10/6/2020
C2  - PMC7526756
DA  - Aug 30
DB  - PubMed
DO  - 10.7759/cureus.10142
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Cureus
KW  - covid-19
heart failure
liver failure
respiratory failure
LA  - eng
N1  - 2168-8184
Makarem, Jalil
Naghibi, Nikoo
Beigmohammadi, Mohammad Taghi
Foroumandi, Morteza
Mehrpooya, Maryam
Case Reports
Cureus. 2020 Aug 30;12(8):e10142. doi: 10.7759/cureus.10142.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10142
ST  - A Case Report of Progressive Liver Failure Inappropriate to Decompensated Heart Failure Following Infection With COVID-19
T2  - Cureus
TI  - A Case Report of Progressive Liver Failure Inappropriate to Decompensated Heart Failure Following Infection With COVID-19
VL  - 12
ID  - 7785382
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To determine the impact of roster reorganization on ensuring uninterrupted services while providing necessary relief to healthcare workers (HCW) in the obstetrics department of a tertiary care center amid the COVID-19 outbreak. METHODS: The COVID-19 rostering response began in April 2020 and evolved in two phases: (1) development of new areas for screening and managing suspected/positive cases of COVID-19; and (2) team segregation according to area of work. The impact of these changes on HCWs and patients was assessed 3 months later. RESULTS: Developing separate areas helped to minimize the risk of exposure of patients and HCWs to those with COVID-19. Residents and consultants worked intensively in clinical areas for 1 week followed by 1-2 weeks of non-clinical or standby assignments, providing adequate opportunity for isolation. Frequent re-evaluation of the roster was nevertheless required as the pandemic progressed. Segregating teams vertically significantly reduced the number of contacts identified on contact tracing and quarantine leaves, while maintaining patient satisfaction with no increase in adverse events. Residents found the roster to be "smart" and "pandemic-appropriate." CONCLUSION: The "COVID emergency roster" helped ensure quality care with minimum risk of exposure and sufficient breaks for physical and psychological recovery of HCWs.
AD  - Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India.
AN  - 33011974
AU  - Mahey, R.
AU  - Sharma, A.
AU  - Kumari, A.
AU  - Kachhawa, G.
AU  - Gupta, M.
AU  - Meena, J.
AU  - Bhatla, N.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1002/ijgo.13408
DP  - NLM
ET  - 2020/10/05
J2  - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
KW  - Covid-19
Pregnancy care
Rostering
Segregated teams
LA  - eng
N1  - 1879-3479
Mahey, Reeta
Sharma, Aparna
Kumari, Archana
Kachhawa, Garima
Gupta, Monica
Meena, Jyoti
Bhatla, Neerja
Journal Article
United States
Int J Gynaecol Obstet. 2020 Oct 4. doi: 10.1002/ijgo.13408.
PY  - 2020
SN  - 0020-7292
ST  - The impact of a segregated team roster on obstetric and gynecology services in response to the COVID-19 pandemic in a tertiary care center in India
T2  - International journal of gynaecology and obstetrics: official organ of International Federation of Gynaecology and Obstetrics
TI  - The impact of a segregated team roster on obstetric and gynecology services in response to the COVID-19 pandemic in a tertiary care center in India
ID  - 7785635
ER  - 

TY  - JOUR
AB  - This paper looks at the disruption in food supply chains due to COVID-19 induced economic shutdown in India We use a novel dataset from one of the largest online grocery retailers to look at the impact on product stockouts and prices We find that product availability falls by 10 percent for vegetables, fruits, and edible oils, while there is a minimal impact on their prices On the farm-gate side, it is matched by a 20 percent fall in quantity arrivals of vegetables and fruits We then show that supply chain disruption is the main driver behind this fall We compute the distance to production zones from our retail centers and find that the fall in product availability and quantity arrivals is larger for items that are cultivated or manufactured farther from the final point of sale Our results show that long-distance food supply chains have been hit the hardest during the current pandemic with welfare consequences for urban consumers and farmers This article is protected by copyright All rights reserved
AU  - Mahajan, Kanika
AU  - Tomar, Shekhar
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 and Supply Chain Disruption: Evidence from Food Markets in India
T2  - American Journal of Agricultural Economics
TI  - COVID-19 and Supply Chain Disruption: Evidence from Food Markets in India
UR  - https://doi.org/10.1111/ajae.12158
ID  - 7788265
ER  - 

TY  - JOUR
AD  - Department of Cardiac Anaesthesia, Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS) and Dr. Ram Manohar Lohia Hospital, Baba Kharak Singh Marg, New Delhi-110001, INDIA.
AN  - 33012159
AU  - Magoon, R.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.4097/kja.20536
DP  - NLM
ET  - 2020/10/06
J2  - Korean journal of anesthesiology
KW  - Acute respiratory distress syndrome
Covid-19
Extravascular lung water
Pulmonary vascular permeability indices
SARS-CoV-2 pneumonia
LA  - eng
N1  - 2005-7563
Magoon, Rohan
Journal Article
Korea (South)
Korean J Anesthesiol. 2020 Oct 5. doi: 10.4097/kja.20536.
PY  - 2020
SN  - 2005-6419
ST  - Pulmonary vasculature in COVID-19: mechanism to monitoring!
T2  - Korean journal of anesthesiology
TI  - Pulmonary vasculature in COVID-19: mechanism to monitoring!
ID  - 7785616
ER  - 

TY  - JOUR
AB  - OBJECTIVE: This rapid review addresses two key questions posed by the COVID-19 pandemic: What are the anticipated mental health sequelae for frontline health workers? and What are best practices during health emergencies to address the mental health needs of these workers? METHODS: This review synthesized the literature on the mental health sequelae for health workers during major pandemics and epidemics that occurred in the 21st century (severe acute respiratory syndrome, Middle East respiratory syndrome, Ebola virus disease, and swine flu) and interventions used to address related mental health sequelae. PubMed, MEDLINE, and PsycINFO were searched with terms related to these epidemics/pandemics. RESULTS: Of 3,876 articles retrieved, 94 were included in this review. Across these studies, most health workers exhibited some adverse psychological experiences during outbreaks, with stress and anxiety being most common. Psychological distress decreased over time. Some studies reported insomnia, burnout, and posttraumatic stress for a subset of individuals up to 3 years after the disease outbreak. Few interventions have been implemented to address providers' mental health needs, and these strategies have not been evaluated systematically. CONCLUSIONS: Systems-level interventions may alleviate distress for most providers without the need for specialized mental health intervention. Psychotherapeutic support and referral to specialty care should be available to health workers with severe and intense adverse psychological outcomes during and beyond the COVID-19 pandemic. Evidence-based interventions are urgently needed to better serve health workers both during and following epidemics/pandemics.
AD  - Columbia-WHO Center for Global Mental Health, Department of Psychiatry, Columbia University Irving Medical Center, New York.
AN  - 33019857
AU  - Magill, E.
AU  - Siegel, Z.
AU  - Pike, K. M.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1176/appi.ps.202000274
DP  - NLM
ET  - 2020/10/07
J2  - Psychiatric services (Washington, D.C.)
KW  - Coronavirus/COVID-19
Frontline workers
Health providers
Mental health
Pandemic
Stress
LA  - eng
N1  - 1557-9700
Magill, Elizabeth
Siegel, Zoe
Pike, Kathleen M
Journal Article
United States
Psychiatr Serv. 2020 Oct 6:appips202000274. doi: 10.1176/appi.ps.202000274.
PY  - 2020
SN  - 1075-2730
SP  - appips202000274
ST  - The Mental Health of Frontline Health Care Providers During Pandemics: A Rapid Review of the Literature
T2  - Psychiatric services (Washington, DC)
TI  - The Mental Health of Frontline Health Care Providers During Pandemics: A Rapid Review of the Literature
ID  - 7785082
ER  - 

TY  - JOUR
AD  - University of Groningen, University Medical Center Groningen, Wenckebach Institute for Medical Education and Training, Groningen, The Netherlands.
Eupha Ethics in Public Health, European Public Health Association, PO Box 1568, 3500 BN Utrecht, The Netherlands.
Department of International Health, Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.
AN  - 33020827
AU  - Maeckelberghe, E.
AU  - Schröder-Bäck, P.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1093/eurpub/ckaa180
DP  - NLM
ET  - 2020/10/07
IS  - 5
J2  - European journal of public health
LA  - eng
N1  - 1464-360x
Maeckelberghe, Els
Schröder-Bäck, Peter
Journal Article
England
Eur J Public Health. 2020 Oct 1;30(5):852-853. doi: 10.1093/eurpub/ckaa180.
PY  - 2020
SN  - 1101-1262
SP  - 852-853
ST  - Covid-19: a test for our humanity
T2  - European journal of public health
TI  - Covid-19: a test for our humanity
VL  - 30
ID  - 7784973
ER  - 

TY  - JOUR
AD  - Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, 535 East 70th St., New York, NY 10021 USA. GRID: grid.239915.5. ISNI: 0000 0001 2285 8823
Department of Anesthesiology, Critical Care & Pain Management, Hospital for Special Surgery, 535 East 70th St., New York, NY 10021 USA. GRID: grid.239915.5. ISNI: 0000 0001 2285 8823
AN  - 33020699
AU  - MacKenzie, C. R.
AU  - Green, D. S. T.
AU  - Chisholm, M. F.
AU  - Waldman, S. A.
C1  - 10/6/2020
C2  - PMC7527662
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s11420-020-09791-3
DP  - NLM
ET  - 2020/10/07
J2  - HSS journal : the musculoskeletal journal of Hospital for Special Surgery
KW  - Covid-19
bioethics
communication
do-not-resuscitate
scarce resources
ventilators
LA  - eng
N1  - MacKenzie, C Ronald
Green, Douglas S T
Chisholm, Mary F
Waldman, Seth A
Journal Article
United States
HSS J. 2020 Oct 1:1-5. doi: 10.1007/s11420-020-09791-3.
PY  - 2020
SN  - 1556-3316 (Print)
1556-3316
SP  - 1-5
ST  - In the Eye of the Storm: Bioethics in the Time of COVID-19
T2  - HSS journal : musculoskeletal journal of Hospital for Special Surgery
TI  - In the Eye of the Storm: Bioethics in the Time of COVID-19
ID  - 7785004
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To analyze factors associated with the deaths of individuals hospitalized with COVID-19 in the state of Esp�Trito Santo, Brazil. METHODS: This was a cross-sectional study using secondary data. Logistic regression models were used to estimate crude and adjusted odds ratios (OR). RESULTS: As at May 14, 2020, 200 individuals had been discharged and 220 had died. Of the total number of people studied, 57.1% were male, 46.4% were &gt;60 years old, 57.9% were cases notified by a private institution, and 61.7% had &gt;1 comorbidity. In the adjusted analysis, hospital mortality was higher for the 51-60 age group (OR=4.33 - 95%CI 1.50;12.46), the over 60 age group (OR=11.84 - 95%CI 4.31;32.54), cases notified by public institutions (OR=8.23 - 95%CI 4.84;13.99) and cases with a greater number of comorbidities (two [OR=2.74 - 95%CI 1.40;5.34] and three [OR=2.90 - 95%CI 1.07;7.81]). CONCLUSION: Higher mortality was found in older individuals, those with comorbidities and users of public hospitals.
AU  - Maciel, Ethel Leonor
AU  - Jabor, Pablo
AU  - Goncalves Júnior, Etereldes
AU  - Tristão-S֙, Ricardo
AU  - Lima, Rita de C֙ssia Duarte
AU  - Reis-Santos, Barbara
AU  - Lira, Pablo
AU  - Bussinguer, Elda Coelho Azevedo
AU  - Zandonade, Eliana
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 4
LA  - pt
PY  - 2020
SP  - e2020413-e2020413
ST  - Fatores associados ao �Qbito hospitalar por COVID-19 no Esp�Trito Santo, 2020
T2  - Epidemiol Serv Saude
TI  - Fatores associados ao �Qbito hospitalar por COVID-19 no Esp�Trito Santo, 2020
TT  - Fatores associados ao �Qbito hospitalar por COVID-19 no Esp�Trito Santo, 2020.
Factors associated with COVID-19 hospital deaths in Esp�Trito Santo, Brazil, 2020.
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-810137
VL  - 29
ID  - 7788743
ER  - 

TY  - JOUR
AB  - BACKGROUND: During the period of health emergency linked to the current COVID-19 pandemic, the paediatric dentists' management of oral health problems in children must have as primary objective the control of the spread of the disease according to specific protocols aimed at minimizing the risk of viral transmission. AIM: This paper examines the possible clinical conditions that may require intervention by the paediatric dentist, distinguishing clinical situations that fall into the category of paediatric dental emergencies from conditions of oral pathologies that normally do not represent an emergency. The definition of rigorous and highly effective infection control protocols in the dental settings must therefore be complemented by the development and strengthening of remote communication techniques with the parents, who must be adequately educated on preventive and palliative measures for the management of their children's oral health, with the aim of postponing clinical attendance to when the circumstances become favourable. CONCLUSIONS: The experience gained with these approaches and models of treatment, where remote interaction techniques play a central role, will hone the communication skills of the paediatric dentist and will retain its usefulness even at the end of the current emergency period.
AD  - Department of Oral and Maxillo-Facial Science, "Sapienza" University of Rome, Rome, Italy.
AN  - 33012056
AU  - Luzzi, V.
AU  - Ierardo, G.
AU  - Bossù, M.
AU  - Polimeni, A.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/ipd.12737
DP  - NLM
ET  - 2020/10/05
J2  - International journal of paediatric dentistry
KW  - COVID-19 pandemic
oral health prevention
paediatric dentistry
LA  - eng
N1  - 1365-263x
Luzzi, Valeria
Orcid: 0000-0002-2502-6077
Ierardo, Gaetano
Bossù, Maurizio
Polimeni, Antonella
Journal Article
England
Int J Paediatr Dent. 2020 Oct 4. doi: 10.1111/ipd.12737.
PY  - 2020
SN  - 0960-7439
ST  - Paediatric Oral Health during and after the COVID-19 Pandemic
T2  - International journal of paediatric dentistry
TI  - Paediatric Oral Health during and after the COVID-19 Pandemic
ID  - 7785627
ER  - 

TY  - JOUR
AB  - COVID-19-related disruptions led to a historic rise in the spread between livestock and wholesale meat prices Concerns about concentration and allegations of anticompetitive behavior have led to several inquiries and civil suits by the U S Department of Agriculture and the U S Department of Justice, with increases in price differentials serving as a focal point This article notes the difference between price spreads and marketing margins, outlines corresponding economic theory, and describes the empirical evidence on wholesale meat and livestock price dynamics in the wake of COVID-19 disruptions At one point during the pandemic, beef and pork packers were both operating at about 60% of the previous year&#039;s processing volume We explore how such a massive supply shock would be expected to affect marketing margins even in the absence of anti-competitive behavior Moreover, we document how margin measurements are critically sensitive to the selection of data and information utilized Finally, we conclude with some discussion around policy proposals that would pit industry concentration against industry coordination and economies of scale
AU  - Lusk, Jayson L.
AU  - Tonsor, Glynn T.
AU  - Schulz, Lee L.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Beef and Pork Marketing Margins and Price Spreads during COVID-19
T2  - Applied Economic Perspectives and Policy
TI  - Beef and Pork Marketing Margins and Price Spreads during COVID-19
UR  - https://doi.org/10.1002/aepp.13101
ID  - 7788128
ER  - 

TY  - JOUR
AB  - OBJECTIVES: To determine the age-specific clinical presentations and incidence of adverse outcomes among patients with COVID-19 in Jiangsu, China. DESIGN AND SETTING: Retrospective, multicentre cohort study performed at 24 hospitals in Jiangsu, China. PARTICIPANTS: 625 patients with COVID-19 enrolled between 10 January and 15 March 2020. RESULTS: Of the 625 patients (median age, 46 years; 329 (52.6%) men), 37 (5.9%) were children (18 years or younger), 261 (41.8%) young adults (19-44 years), 248 (39.7%) middle-aged adults (45-64 years) and 79 (12.6%) elderly adults (65 years or older). The incidence of hypertension, coronary heart disease, chronic obstructive pulmonary disease and diabetes comorbidities increased with age (trend test, p0.0001, p=0.0003, p0.0001 and p0.0001, respectively). Fever, cough and shortness of breath occurred more commonly among older patients, especially the elderly, compared with children (χ(2) test, p=0.0008, 0.0146 and 0.0282, respectively). The quadrant score and pulmonary opacity score increased with age (trend test, both p0.0001). Older patients had many significantly different laboratory parameters from younger patients. Elderly patients had the highest proportion of severe or critically-ill cases (33.0%, χ(2) test p0.0001), intensive care unit use (35.4%, χ(2) test p0.0001), respiratory failure (31.6%, χ(2) test p0.0001) and the longest hospital stay (median 21 days, Kruskal-Wallis test p0.0001). CONCLUSIONS: Elderly (�?5 years) patients with COVID-19 had the highest risk of severe or critical illness, intensive care use, respiratory failure and the longest hospital stay, which may be due partly to their having a higher incidence of comorbidities and poor immune responses to COVID-19.
AD  - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.
Department of Radiology, Southeast University Zhongda Hospital, Nanjing, China.
Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China yiyiyang2004@163.com Duolao.Wang@lstmed.ac.uk.
Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom yiyiyang2004@163.com Duolao.Wang@lstmed.ac.uk.
AN  - 33020106
AU  - Luo, H.
AU  - Liu, S.
AU  - Wang, Y.
AU  - Phillips-Howard, P. A.
AU  - Ju, S.
AU  - Yang, Y.
AU  - Wang, D.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/bmjopen-2020-039887
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - BMJ open
KW  - epidemiology
infectious diseases
public health
LA  - eng
N1  - 2044-6055
Luo, Huanyuan
Liu, Songqiao
Wang, Yuancheng
Phillips-Howard, Penelope A
Ju, Shenghong
Orcid: 0000-0002-2497-4286
Yang, Yi
Wang, Duolao
Orcid: 0000-0003-2788-2464
Journal Article
England
BMJ Open. 2020 Oct 5;10(10):e039887. doi: 10.1136/bmjopen-2020-039887.
PY  - 2020
SN  - 2044-6055
SP  - e039887
ST  - Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multicentre cohort study
T2  - BMJ open
TI  - Age differences in clinical features and outcomes in patients with COVID-19, Jiangsu, China: a retrospective, multicentre cohort study
VL  - 10
ID  - 7785054
ER  - 

TY  - JOUR
AU  - Lühken, Arnim
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Chemie unterrichten und lernen in der Corona-Zeit �?Neue Wege finden!
T2  - CHEMKON
TI  - Chemie unterrichten und lernen in der Corona-Zeit �?Neue Wege finden!
UR  - https://doi.org/10.1002/ckon.202000070
ID  - 7788138
ER  - 

TY  - JOUR
AB  - A pandemic linked to the new coronavirus strain (SARS-CoV-2) has been raging for several months. Pediatric populations are less impacted than adults, and critical respiratory diseases seem rare (1, 2). We report the case of an infant, who presented with life-threatening apneas at home requiring basic life support. SARS-CoV-2 was subsequently identified in the patient's nasopharyngeal aspirate. He did not present with bronchiolitis or hypoxic failure as described in severe forms of COVID-19. The outcome was favorable in a few hours. The occurrence of apneas is not uncommon during viral respiratory infections in early infancy; however, there are very few descriptions related to a documented SARS-CoV-2 respiratory tract infection. In light of this clinical case, it seems necessary to quickly bring up a potential COVID-19 contamination in infants admitted for life-threatening apnea, in order to properly report and isolate these patients to avoid further nosocomial dissemination of SARS-CoV-2. © Copyright © 2020 Loron, Tromeur, Venot, Beck, Andreoletti, Mauran and Bednarek.
AD  - (Loron, Tromeur, Venot, Beck, Mauran, Bednarek) Department of Pediatrics, CHU Reims, Reims, France (Loron, Bednarek) CReSTIC / EA 3804, Reims Champagne-Ardenne University, Reims, France (Loron, Tromeur, Bednarek) Medical University Reims Champagne-Ardenne University, Reims, France (Andreoletti) Reims Champagne-Ardenne University, Reims, France (Andreoletti) Department of Virology, CHU Reims, Reims, France (Mauran) Pediatric Cardiology Unit, CHU Reims, Reims, France
G. Loron, Department of Pediatrics, CHU Reims, Reims, France. E-mail: gloron@chu-reims.fr G. Loron, CReSTIC / EA 3804, Reims Champagne-Ardenne University, Reims, France. E-mail: gloron@chu-reims.fr G. Loron, Medical University Reims Champagne-Ardenne University, Reims, France. E-mail: gloron@chu-reims.fr
AN  - 632973887
AU  - Loron, G.
AU  - Tromeur, T.
AU  - Venot, P.
AU  - Beck, J.
AU  - Andreoletti, L.
AU  - Mauran, P.
AU  - Bednarek, N.
C1  - 10/6/2020
DA  - 15 Sep
DB  - Embase
DO  - http://dx.doi.org/10.3389/fped.2020.00568
DP  - Ovid Technologies
IS  - 568
KW  - apnea
case report
children
coronavirus
SARS-CoV-2
article
basic life support
bronchiolitis
clinical article
contamination
coronavirus disease 2019
human
infancy
infant
male
nasopharyngeal aspiration
respiratory tract infection
treatment failure
LA  - English
PY  - 2020
SN  - 2296-2360 (electronic)
2296-2360
ST  - COVID-19 Associated With Life-Threatening Apnea in an Infant Born Preterm: A Case Report
T2  - Frontiers in Pediatrics
TI  - COVID-19 Associated With Life-Threatening Apnea in an Infant Born Preterm: A Case Report
UR  - https://www.frontiersin.org/journals/pediatrics
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632973887
VL  - 8 (no pagination)
ID  - 7782916
ER  - 

TY  - JOUR
AB  - BACKGROUND The coronavirus disease 2019 (COVID-19) pandemic is hitting many countries. It is hypothesized the epidemic is differentially progressing in different countries. AIM To investigate how the COVID-19 epidemic is going on in different countries by analyzing representative countries. METHODS The status of COVID-19 epidemic in over 60 most affected countries was characterized. The data of daily new cases of each country were collected from Worldometer. The data of daily tests for the United States, Italy, and South Korea were collected from the Website of One World Data. Levels of daily positive COVID-19 tests in the two most affected states of the United States (New York and New Jersey) were collected from the website of the COVID Tracking Project. Statistics were analyzed using Microcal Origin software with ANOVA algorithm, and significance level was set at a P value of 0.05. RESULTS The COVID-19 epidemic was differentially progressing in different countries. Comparative analyses of daily new cases as of April 19, 2020 revealed that 61 most affected countries can be classified into four types: Downward (22), upward (20), static-phase (12), and uncertain ones (7). In particular, the 12 static-phase countries including the United States were characterized by largely constant numbers of daily new cases in the past over 14 d. Furthermore, these static-phase countries were overall significantly lower in testing density (P = 0.016) but higher in the level of positive COVID-19 tests than downward countries (P = 0.028). These findings suggested that the testing capacity in static-phase countries was lagging behind the spread of the outbreak, i.e., daily new cases (confirmed) were likely less than daily new infections and the remaining undocumented infections were thus still expanding, resulting in unstoppable epidemic. CONCLUSION Increasing the testing capacity and/or reducing the COVID-19 transmission are urgently needed to stop the potentially unstoppable, severing crisis in static-phase countries. Copyright © The Author(s) 2020.
AD  - (Long) Department of Orthopaedics, Sichuan University West China Hospital, Chengdu, Sichuan Province 610041, China (Fu) College of Life Sciences, Fujian Normal University, Fuzhou, Fujian Province 350117, China (Fu) Anxi AIER Eye Hospital (AIER EYE Hospital Group), Anxi, Fujian Province 362400, China
Z.-F. Fu, Anxi AIER Eye Hospital (AIER EYE Hospital Group), Anxi County, Anxi, Fujian Province 362400, China. E-mail: fu_zhifu@163.com
AN  - 632998336
AU  - Long, C.
AU  - Fu, X. M.
AU  - Fu, Z. F.
C1  - 10/6/2020
DA  - 01 Oct
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i19.4431
DP  - Ovid Technologies
IS  - 19
KW  - Coronavirus
covid-19
Pandemic
SARS-CoV-2
Testing density
algorithm
analysis of variance
article
controlled study
coronavirus disease 2019
epidemic
human
Italy
New Jersey
New York
software
South Korea
LA  - English
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 4431-4442
ST  - Global analysis of daily new COVID-19 cases reveals many static-phase countries including the United States potentially with unstoppable epidemic
T2  - World Journal of Clinical Cases
TI  - Global analysis of daily new COVID-19 cases reveals many static-phase countries including the United States potentially with unstoppable epidemic
UR  - https://f6publishing.blob.core.windows.net/d5d45e61-9a16-4616-ab78-c3741d910ee5/WJCC-8-4431.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998336
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i19.4431&issn=2307-8960&isbn=&volume=8&issue=19&spage=4431&pages=4431-4442&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Global+analysis+of+daily+new+COVID-19+cases+reveals+many+static-phase+countries+including+the+United+States+potentially+with+unstoppable+epidemic&aulast=Long&pid=%3Cauthor%3ELong+C.%2CFu+X.-M.%2CFu+Z.-F.%3C%2Fauthor%3E&%3CAN%3E632998336%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 8
ID  - 7782817
ER  - 

TY  - JOUR
AB  - BACKGROUND: This article explores the effectiveness of development of the Lo's Healthy and Happy Lifestyle Scale (LHHLS), which is an evaluative tool that monitors the resilience of the Taiwan population in times of such COVID-19 epidemic. Also, to verify factors of resilience, namely the reliability and validity of self-efficacy and positive thinking, and establishment of a prospective norm analysis. METHOD: The study mainly applied Explorative Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA) to develop LHHLS and establish the reliability and validity of the tool's structure, verify norm analysis and the reliability of data from each question using Cronbach's alpha. RESULTS: According to statistics, LHHLS has a good factorial effectiveness and relatively high reliability, with factor reliability analyses where Cronbach's alpha lies between 0.83 to 0.94. The 14 questions in the LHHLS has a total variance of 67.04%. The tool includes two sub-assessments that are theoretically and statistically appropriate: mental health/self-efficacy and positive thinking. CONCLUSION: The tool LHHLS can be applied to populations affected by COVID-19. With participants' self-awareness of mental health state and state of happy living, this tool is valid and reliable in assessing and evaluating the resilience of such participants against times of COVID-19. This study can become future use for epidemic prevention communities in monitoring residents' healthy living and changes in their resilience. Also, can become a reference standard for interventions to reduce the impacts populations' happy and healthy living, in times of biological disasters.
AD  - Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung.
Department of Child and Adolescent Psychiatry, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung.
Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung.
Department of Adult Psychiatry, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung.
Graduate Institute of Humanities in Medicine, Taipei Medical University, Taipei.
Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung.
Graduate Institute of Gender Education, National Kaohsiung Normal University, Kaohsiung.
AN  - 33012222
AU  - Lo, A.
AU  - Hsieh, K. Y.
AU  - Lu, W. C.
AU  - Shieh, I.
AU  - Chou, F. H.
AU  - Shieh, V.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1177/0020764020960771
DP  - NLM
ET  - 2020/10/06
J2  - The International journal of social psychiatry
KW  - Covid-19
Healthy and Happy Lifestyle Scale (LHHLS)
positive thinking
resilience norm verification
self-efficacy
LA  - eng
N1  - 1741-2854
Lo, Angela
Hsieh, Kuan-Ying
Orcid: 0000-0002-6728-0807
Lu, Wan-Chun
Shieh, Ierna
Chou, Frank Huang-Chih
Orcid: 0000-0001-7802-3489
Shieh, Vincent
Journal Article
England
Int J Soc Psychiatry. 2020 Oct 3:20764020960771. doi: 10.1177/0020764020960771.
PY  - 2020
SN  - 0020-7640
SP  - 20764020960771
ST  - Development and validation of the Lo's Healthy and Happy Lifestyle Scale (LHHLS): The resilience in general population facing COVID-19 in Taiwan
T2  - International journal of social psychiatry
TI  - Development and validation of the Lo's Healthy and Happy Lifestyle Scale (LHHLS): The resilience in general population facing COVID-19 in Taiwan
ID  - 7785610
ER  - 

TY  - JOUR
AB  - For all health conditions, reliable age-disaggregated data are vital for both epidemiological analysis and monitoring the relative prioritization of different age groups in policy responses. This is especially essential in the case of Coronavirus Disease-2019 (COVID-19), given the strong association between age and case fatality. This paper assesses the availability and quality of age-based data on reported COVID-19 cases and deaths for low and middle-income countries. It finds that the availability of reliable data which permit specific analyses of older people is largely absent. The paper explores the potential of excess mortality estimates as an alternative metric of the pandemic's effects on older populations. Notwithstanding some technical challenges, this may offer a better approach, especially in countries where cause of death data is unreliable.
AD  - School of International Development, University of East Anglia, Norwich. Norfolk, UK.
Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK.
School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, UK.
AN  - 33017839
AU  - Lloyd-Sherlock, P.
AU  - Sempe, L.
AU  - McKee, M.
AU  - Guntupalli, A.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/geront/gnaa153
DP  - NLM
ET  - 2020/10/06
J2  - The Gerontologist
KW  - Ageism
Covid-19
Data
Low- and middle-income countries
LA  - eng
N1  - 1758-5341
Lloyd-Sherlock, Peter
Sempe, Lucas
McKee, Martin
Guntupalli, Aravinda
Journal Article
United States
Gerontologist. 2020 Oct 6:gnaa153. doi: 10.1093/geront/gnaa153.
PY  - 2020
SN  - 0016-9013
ST  - Problems of Data Availability and Quality for COVID-19 and Older People in Low- and Middle-Income Countries
T2  - Gerontologist
TI  - Problems of Data Availability and Quality for COVID-19 and Older People in Low- and Middle-Income Countries
ID  - 7785115
ER  - 

TY  - JOUR
AD  - Advocate Good Samaritan Hospital, Downers Grove, IL
AN  - 146192893. Language: English. Entry Date: In Process. Revision Date: 20201005. Publication Type: Article. Supplement Title: 2020 Supplement. Journal Subset: Biomedical
AU  - Livorsi-Moore, Jeanne
AU  - Malick, Owais
AU  - Valika, Ali
C1  - 10/6/2020
DB  - cin20
DO  - 10.1016/j.cardfail.2020.09.303
DP  - EBSCOhost
IS  - 10
N1  - Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9442138.
PY  - 2020
SN  - 1071-9164
SP  - S104-S105
ST  - Outpatient Ultrafiltration to Prevent Hospital Readmission During Covid 19 Pandemic in Diuretic Intolerant Patient: Case Study
T2  - Journal of Cardiac Failure
TI  - Outpatient Ultrafiltration to Prevent Hospital Readmission During Covid 19 Pandemic in Diuretic Intolerant Patient: Case Study
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=146192893&site=ehost-live
VL  - 26
ID  - 7784598
ER  - 

TY  - JOUR
AD  - (Liu, Prestigiacomo, Cyders) Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States (Plawecki) Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, United States
M. Liu, Department of Psychology, Indiana University Purdue University Indianapolis, Indianapolis, IN, United States. E-mail: maliu@iu.edu
AN  - 2007961271
AU  - Liu, M.
AU  - Prestigiacomo, C. J.
AU  - Plawecki, M. H.
AU  - Cyders, M. A.
C1  - 10/6/2020
DA  - November
DB  - Embase
DO  - http://dx.doi.org/10.1016/j.psychres.2020.113469
DP  - Ovid Technologies
IS  - 113469
KW  - coronavirus disease 2019
female
gender
human
letter
male
pandemic
writing
LA  - English
M3  - Letter
PY  - 2020
SN  - 0165-1781
1872-7123
ST  - Correspondence on gender disparities in the initial psychological impact of the U.S. COVID-19 pandemic
T2  - Psychiatry Research
TI  - Correspondence on gender disparities in the initial psychological impact of the U.S. COVID-19 pandemic
UR  - http://www.elsevier.com/locate/psychres
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007961271
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1016%2Fj.psychres.2020.113469&issn=0165-1781&isbn=&volume=293&issue=&spage=&pages=&date=2020&title=Psychiatry+Research&atitle=Correspondence+on+gender+disparities+in+the+initial+psychological+impact+of+the+U.S.+COVID-19+pandemic&aulast=Liu&pid=%3Cauthor%3ELiu+M.%2CPrestigiacomo+C.J.%2CPlawecki+M.H.%2CCyders+M.A.%3C%2Fauthor%3E&%3CAN%3E2007961271%3C%2FAN%3E&%3CDT%3ELetter%3C%2FDT%3E
VL  - 293 (no pagination)
ID  - 7782814
ER  - 

TY  - JOUR
AB  - Objective: Recently, the number of gynecological cancer patients infected with SARS-CoV-2 has been increasing. This article was committed to studying the influence of gynecological tumor treatment history compared to the Coronavirus Disease 2019 (COVID-19), which was of great significance for the treatment of gynecological cancer patients during the outbreak of COVID-19. Method(s): We retrospectively analyzed the diagnosis and treatment of six gynecological cancer patients infected with SARS-CoV-2 in Tongji Hospital in Wuhan from January 30 to March 25, 2020. To better explain the treatment of gynecological cancer patients during the epidemic of COVID-19, we summarized the case characteristics, auxiliary examination, treatment plan, and outcome of these six patients. Result(s): We observed a high rate of nosocomial SARS-CoV-2 infection among these six gynecological cancer patients, who were in a low immune state. Also, due to the influence of cancer treatment history, COVID-19-related atypical symptoms became the first symptom of COVID-19 in some cases, which increased the difficulty of diagnosis. Furthermore, in terms of treatment for these cases, immune boosters and reagents that raised white blood cells were applied, except for in symptomatic antiviral treatment. At present, all patients in this study were discharged from the hospital with a good prognosis. Conclusion(s): After cancer-related treatment, the gynecological cancer patients became more susceptible to COVID-19. Besides, the history of cancer treatment made the diagnosis of COVID-19 difficult, which also affected the treatment of COVID-19. Therefore, we put forward the corresponding therapy suggestions for gynecological cancer patients during the outbreak of COVID-19. © Copyright © 2020 Liu, Huang, Qin, Guo, Wu, Sun and Chen.
AD  - (Guo) Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
P. Wu C. Sun G. Chen
AU  - Liu, C.
AU  - Huang, Y.
AU  - Qin, T.
AU  - Guo, E.
AU  - Wu, P.
AU  - Sun, C.
AU  - Chen, G.
C1  - 10/6/2020
DA  - 15 Sep
DO  - http://dx.doi.org/10.3389/fonc.2020.01606
DP  - Ui - 632973739
IS  - 1606
KW  - covid-19
gynecological cancer
SARS-CoV-2
suggestions
treatment
adult
antiviral therapy
article
cancer chemotherapy
cancer patient
cancer prognosis
cancer radiotherapy
case study
clinical article
coronavirus disease 2019
epidemic
female
female genital tract cancer
human
human cell
leukocyte
prognosis
retrospective study
tumor-related gene
LA  - English
PY  - 2020
SN  - 2234-943X (electronic)
2234-943X
ST  - Six Gynecological Cancer Patients Infected With SARS-CoV-2 After Surgery or Radio-/Chemo-Therapy Treatment: Case Series
T2  - Frontiers in Oncology
TI  - Six Gynecological Cancer Patients Infected With SARS-CoV-2 After Surgery or Radio-/Chemo-Therapy Treatment: Case Series
UR  - http://www.frontiersin.org/Oncology/about
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632973739
VL  - 10 (no pagination)
ID  - 7782919
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Covid-19 can involve multiple organs including the nervous system. We sought to characterize the neurologic manifestations, their risk factors, and associated outcomes in hospitalized patients with Covid-19. METHODS: We examined neurologic manifestations in 509 consecutive patients admitted with confirmed Covid-19 within a hospital network in Chicago, Illinois. We compared the severity of Covid-19 and outcomes in patients with and without neurologic manifestations. We also identified independent predictors of any neurologic manifestations, encephalopathy, and functional outcome using binary logistic regression. RESULTS: Neurologic manifestations were present at Covid-19 onset in 215 (42.2%), at hospitalization in 319 (62.7%), and at any time during the disease course in 419 patients (82.3%). The most frequent neurologic manifestations were myalgias (44.8%), headaches (37.7%), encephalopathy (31.8%), dizziness (29.7%), dysgeusia (15.9%), and anosmia (11.4%). Strokes, movement disorders, motor and sensory deficits, ataxia, and seizures were uncommon (0.2 to 1.4% of patients each). Severe respiratory disease requiring mechanical ventilation occurred in 134 patients (26.3%). Independent risk factors for developing any neurologic manifestation were severe Covid-19 (OR 4.02; 95% CI 2.04-8.89; P  0.001) and younger age (OR 0.982; 95% CI 0.968-0.996; P = 0.014). Of all patients, 362 (71.1%) had a favorable functional outcome at discharge (modified Rankin Scale 0-2). However, encephalopathy was independently associated with worse functional outcome (OR 0.22; 95% CI 0.11-0.42; P  0.001) and higher mortality within 30 days of hospitalization (35 [21.7%] vs. 11 [3.2%] patients; P  0.001). INTERPRETATION: Neurologic manifestations occur in most hospitalized Covid-19 patients. Encephalopathy was associated with increased morbidity and mortality, independent of respiratory disease severity.
AD  - Ken & Ruth Davee Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
AN  - 33016619
AU  - Liotta, E. M.
AU  - Batra, A.
AU  - Clark, J. R.
AU  - Shlobin, N. A.
AU  - Hoffman, S. C.
AU  - Orban, Z. S.
AU  - Koralnik, I. J.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/acn3.51210
DP  - NLM
ET  - 2020/10/06
J2  - Annals of clinical and translational neurology
LA  - eng
N1  - 2328-9503
Liotta, Eric M
Orcid: 0000-0003-3182-585x
Batra, Ayush
Orcid: 0000-0002-4783-5801
Clark, Jeffrey R
Shlobin, Nathan A
Hoffman, Steven C
Orban, Zachary S
Koralnik, Igor J
Orcid: 0000-0001-6836-1468
Journal Article
United States
Ann Clin Transl Neurol. 2020 Oct 5. doi: 10.1002/acn3.51210.
PY  - 2020
SN  - 2328-9503
ST  - Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients
T2  - Annals of clinical and translational neurology
TI  - Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients
ID  - 7785191
ER  - 

TY  - JOUR
AB  - Background Giant inguinal hernia(GIH), a rare disease, has brought great challenges to surgeons. GIH is defined as an inguinal hernia that extends below the midpoint of the inner thigh in standing position. However, a giant recurrent inguinal hernia resulting from previous operations that destroy the anatomical structure of the inguinal region is extremely rare. Nerve injury, a complication following inguinal hernia repair, is mostly found in ilioinguinal nerve and iliohypogastric nerve, which often presents as numbness and acute or chronic pain, while postoperative muscular dysfunction results from femoral nerve injury is rare. Case presentation A 77-years-old woman presented with a complaint of a reducible mass in the left inguinal of duration 1 year. The patient had three previous inguinal hernia repairs. Physical examination and auxiliary examination indicated a giant inguinal hernia with femoral nerve injury. After preoperative evaluation and preparation, a transabdominal partial extraperitoneal(TAPE) repair have performed. Finally, the patient recovered and was discharged. Conclusions In conclusion, we reported a rare case of a giant recurrent inguinal hernia with femoral nerve injury and made a successful treatment for the patient via transabdominal partial extraperitoneal(TAPE) repair.
AN  - 2414593824
AU  - Lin, Manzhou
AU  - Long, Guojie
AU  - Chen, Ming
AU  - Chen, Weice
AU  - Mo, Jian
AU  - Chen, Nianping
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1186/s12893-020-00786-9
DP  - ProQuest Central
KW  - Medical Sciences--Surgery
Giant inguinal hernia
Recurrent hernia
Nerve injury
Inguinal hernia repair
Patients
Surgery
Hernias
Hernia
Femur
Pain
Electromyography
Abdomen
Atrophy
Thigh
Injuries
COVID-19
LA  - English
N1  - Copyright - © 2020. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SP  - 1-9
ST  - Giant recurrent left inguinal hernia with femoral nerve injury: a report of a rare case
T2  - BMC Surgery
TI  - Giant recurrent left inguinal hernia with femoral nerve injury: a report of a rare case
UR  - https://www.proquest.com/docview/2414593824?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=unknown&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Giant+recurrent+left+inguinal+hernia+with+femoral+nerve+injury%3A+a+report+of+a+rare+case&title=BMC+Surgery&issn=&date=2020-01-01&volume=20&issue=&spage=1&au=Lin%2C+Manzhou%3BLong%2C+Guojie%3BChen%2C+Ming%3BChen%2C+Weice%3BMo%2C+Jian%3BChen%2C+Nianping&isbn=&jtitle=BMC+Surgery&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1186%2Fs12893-020-00786-9
VL  - 20
ID  - 7784958
ER  - 

TY  - JOUR
AB  - A large number of studies are being conducted to evaluate the efficacy and safety of candidate vaccines against novel coronavirus disease-2019 (COVID-19). Most Phase 3 trials have adopted virologically confirmed symptomatic COVID-19 disease as the primary efficacy endpoint, although laboratory-confirmed SARS-CoV-2 is also of interest. In addition, it is important to evaluate the effect of vaccination on disease severity. To provide a full picture of vaccine efficacy and make efficient use of available data, we propose using SARS- CoV-2 infection, COVID-19, and severe COVID-19 as dual or triple primary endpoints. We demonstrate the advantages of this strategy through realistic simulation studies. Finally, we show how this approach can provide rigorous interim monitoring of the trials and efficient assessment of the durability of vaccine efficacy.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external funding was received for this work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Not applicableAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe simulated datasets are available from the corresponding author upon reasonable request.
AU  - Lin, Dan-Yu
AU  - Zeng, Donglin
AU  - Mehrotra, Devan V.
AU  - Corey, Lawrence
AU  - Gilbert, Peter B.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205906
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205906
ST  - Evaluating the Efficacy of COVID-19 Vaccines (preprint)
T2  - medRxiv
TI  - Evaluating the Efficacy of COVID-19 Vaccines (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205906.abstract
ID  - 7788876
ER  - 

TY  - JOUR
AB  - PURPOSE: This study was conducted to determine the feasibility of providing an eHealth intervention for health-related quality of life (HRQOL) to facilitate patient self-management. METHODS: A randomized controlled trial was conducted from 2019-2020 within the Pain Registry for Epidemiological, Clinical, and Interventional Studies and Innovation. Eligible patients included those with chronic low back pain and a SPADE (sleep disturbance, pain interference with activities, anxiety, depression, and low energy/fatigue) cluster score �?55 based on the relevant scales from the Patient-Reported Outcomes Measurement Information System instrument with 29 items (PROMIS-29). Patients were randomized to the eHealth treatment group, which received a tailored HRQOL report and interpretation guide, or to a wait-list control group. The primary outcome was change in the SPADE cluster score, including its five component scales, over 3 months. Secondary outcomes were changes in low back pain intensity and back-related disability. Treatment effects were measured using the standardized mean difference (SMD) in change scores between groups. The eHealth intervention was also assessed by a survey of the experimental treatment group 1 month following randomization. RESULTS: A total of 102 patients were randomized, including 52 in the eHealth treatment group and 50 in the wait-list control group, and 100 (98%) completed the trial. A majority of patients agreed that the HRQOL report was easy to understand (86%), provided new information (79%), and took actions to read or learn more about self-management approaches to improve their HRQOL (77%). Although the eHealth intervention met the criteria for a small treatment effect in improving the overall SPADE cluster score (SMD = 0.24; p= 0.23) and anxiety (SMD = 0.24; p = 0.23), and for a small-to-medium treatment effect in improving depression (SMD = 0.37; p = 0.06) and back-related disability (SMD = 0.36; p = 0.07), none of these results achieved statistical significance because of limited sample size. CONCLUSION: Given the feasibility of rapid online deployment, low cost, and low risk of adverse events, this eHealth intervention for HRQOL may be useful for patients with chronic pain during the COVID-19 pandemic.
AD  - Department of Family Medicine, University of North Texas Health Science Center, Fort Worth, TX 76203, USA.
AN  - 33019676
AU  - Licciardone, J. C.
AU  - Pandya, V.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/healthcare8040381
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Healthcare (Basel, Switzerland)
KW  - Covid-19
back-related disability
chronic low back pain
eHealth
health-related quality of life
low back pain intensity
randomized controlled trial
LA  - eng
N1  - Licciardone, John C
Pandya, Vishruti
N/A/University of North Texas Health Science Center, Office of Research Development and Commercialization/
Journal Article
Switzerland
Healthcare (Basel). 2020 Oct 1;8(4):E381. doi: 10.3390/healthcare8040381.
PY  - 2020
SN  - 2227-9032 (Print)
2227-9032
ST  - Feasibility Trial of an eHealth Intervention for Health-Related Quality of Life: Implications for Managing Patients with Chronic Pain during the COVID-19 Pandemic
T2  - Healthcare (Basel, Switzerland)
TI  - Feasibility Trial of an eHealth Intervention for Health-Related Quality of Life: Implications for Managing Patients with Chronic Pain during the COVID-19 Pandemic
VL  - 8
ID  - 7785089
ER  - 

TY  - JOUR
AB  - [This corrects the article DOI: 10.1016/j.xinn.2020.100028.].
AN  - 33016958
AU  - Li, H. T.
AU  - Cheng, Z. H.
AU  - Huang, Y. Y.
AU  - Lv, X. L.
AU  - Zhou, Y. B.
AU  - Dong, E.
AU  - Liu, J. M.
C1  - 10/6/2020
C2  - PMC7519756
DA  - Sep 26
DB  - PubMed
DO  - 10.1016/j.xinn.2020.100046
DP  - NLM
ET  - 2020/10/06
J2  - Innovation (New York, N.Y.)
LA  - eng
N1  - 2666-6758
Li, Hong-Tian
Cheng, Zhi-Hao
Huang, Yong-Ying
Lv, Xi-Lin
Zhou, Yu-Bo
Dong, Erdan
Liu, Jian-Meng
Published Erratum
United States
Innovation (N Y). 2020 Sep 26:100046. doi: 10.1016/j.xinn.2020.100046.
PY  - 2020
SN  - 2666-6758
SP  - 100046
ST  - Erratum: Patients' Attitudes to Unproven Therapies in Treating COVID-19 Merit Evaluation
T2  - Innovation (New York, NY)
TI  - Erratum: Patients' Attitudes to Unproven Therapies in Treating COVID-19 Merit Evaluation
ID  - 7785171
ER  - 

TY  - JOUR
AB  - BACKGROUND: To better understand the impact of common coronaviruses, we compared outcomes in inpatients and outpatients, pre-COVID19, who were infected with either coronavirus or influenza. METHODS: Using de-identified EHR data from the Geisinger-Regeneron DiscovEHR partnership, we compared patients with confirmed RT-PCR positive tests for the four common coronaviruses (229E, HKU1, NL63, OC43) or influenza (A and B) performed from June 2016 to February 2019. RESULTS: Overall, 52,833 patients were tested for coronaviruses and influenza viruses. For patients =21 years old, 1,555 and 3,991 patient encounters had confirmed positive coronavirus and influenza tests, respectively. Both groups had similar ICU admission rates (7.2% vs. 6.1%, p=0.12), though patients with coronavirus had significantly more pneumonia (15% vs. 7.4%, p0.001) and a higher death rate within 30 days of testing (4.9% vs. 3.0%, p0.001). After controlling for other covariates, coronavirus infection still had a higher risk of death and pneumonia than influenza (OR 1.64 and 2.05, p0.001), with no significant difference in ICU admission rates. CONCLUSIONS: Common coronaviruses cause significant morbidity, with potentially worse outcomes than influenza. These findings may help identify a subset of patients who are more susceptible to poor outcomes from common coronavirus infections and may help plan clinical interventions in patients with suspected infections.
AD  - Regeneron Genetics Center, Tarrytown, NY, USA.
Geisinger Health System, Danville, PA, USA.
AN  - 33011809
AU  - Li, D.
AU  - Wolk, D. M.
AU  - Cantor, M. N.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1093/infdis/jiaa626
DP  - NLM
ET  - 2020/10/05
J2  - The Journal of infectious diseases
KW  - common coronavirus
electronic health records
epidemiology
influenza
LA  - eng
N1  - 1537-6613
Li, Dadong
Wolk, Donna M
Cantor, Michael N
Journal Article
United States
J Infect Dis. 2020 Oct 3:jiaa626. doi: 10.1093/infdis/jiaa626.
PY  - 2020
SN  - 0022-1899
ST  - Comparing Clinical Characteristics of Influenza and Common Coronavirus Infections using Electronic Health Records
T2  - Journal of infectious diseases
TI  - Comparing Clinical Characteristics of Influenza and Common Coronavirus Infections using Electronic Health Records
ID  - 7785652
ER  - 

TY  - JOUR
AB  - For the last two decades, researchers have placed hopes in a new era in which a combination of reperfusion and neuroprotection would revolutionize the treatment of stroke. Nevertheless, despite the thousands of papers available in the literature showing positive results in preclinical stroke models, randomized clinical trials have failed to show efficacy. It seems clear now that the existing data obtained in preclinical research have depicted an incomplete picture of stroke pathophysiology. In order to ameliorate bench-to-bed translation, in this review we first describe the main actors on stroke inflammatory and immune responses based on the available preclinical data, highlighting the fact that the link between leukocyte infiltration, lesion volume and neurological outcome remains unclear. We then describe what is known on neuroinflammation and immune responses in stroke patients, and summarize the results of the clinical trials on immunomodulatory drugs. In order to understand the gap between clinical trials and preclinical results on stroke, we discuss in detail the experimental results that served as the basis for the summarized clinical trials on immunomodulatory drugs, focusing on (i) experimental stroke models, (ii) the timing and selection of outcome measuring, (iii) alternative entry routes for leukocytes into the ischemic region, and (iv) factors affecting stroke outcome such as gender differences, ageing, comorbidities like hypertension and diabetes, obesity, tobacco, alcohol consumption and previous infections like Covid-19. We can do better for stroke treatment, especially when targeting inflammation following stroke. We need to re-think the design of stroke experimental setups, notably by (i) using clinically relevant models of stroke, (ii) including both radiological and neurological outcomes, (iii) performing long-term follow-up studies, (iv) conducting large-scale preclinical stroke trials, and (v) including stroke comorbidities in preclinical research.
AD  - Normandie Univ, UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C), UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Caen, France.
Normandie Univ, UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C), UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Caen, France; CHU Caen, Department of Clinical Research, Caen University Hospital, Avenue de la Côte de Nacre, Caen, France.
Normandie Univ, UNICAEN, INSERM, GIP Cyceron, Institut Blood and Brain @Caen-Normandie (BB@C), UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Caen, France. Electronic address: rubio@cyceron.fr.
AN  - 33017613
AU  - Levard, D.
AU  - Buendia, I.
AU  - Lanquetin, A.
AU  - Glavan, M.
AU  - Vivien, D.
AU  - Rubio, M.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.bbi.2020.09.025
DP  - NLM
ET  - 2020/10/06
J2  - Brain, behavior, and immunity
KW  - clinical trials
experimental models
immune response
inflammation
ischemic stroke
translational research
LA  - eng
N1  - 1090-2139
Levard, Damien
Buendia, Izaskun
Lanquetin, Anastasia
Glavan, Martina
Vivien, Denis
Rubio, Marina
Journal Article
Review
Netherlands
Brain Behav Immun. 2020 Oct 2:S0889-1591(20)31483-5. doi: 10.1016/j.bbi.2020.09.025.
PY  - 2020
SN  - 0889-1591
ST  - Filling the gaps on stroke research: focus on inflammation and immunity
T2  - Brain, behavior, and immunity
TI  - Filling the gaps on stroke research: focus on inflammation and immunity
ID  - 7785125
ER  - 

TY  - JOUR
AU  - Leonardi, Paul M.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID and the New Technologies of Organizing:Digital Exhaust, Digital Footprints, and Artificial Intelligence in the Wake of Remote Work
T2  - Journal of Management Studies
TI  - COVID and the New Technologies of Organizing:Digital Exhaust, Digital Footprints, and Artificial Intelligence in the Wake of Remote Work
UR  - https://doi.org/10.1111/joms.12648
ID  - 7788294
ER  - 

TY  - JOUR
AB  - Migrant and seasonal farmworkers, who are essential workers in the coronavirus global public health emergency, face unique risks to their health as well as longstanding health inequities. This commentary highlights these risks and argues that Internet access represents an underappreciated but critical part of the public health response. The authors first discuss the unique risks farmworkers face. We note the importance of Internet access in the time of physical distancing, the fact that many health outreach workers are no longer visiting camps, the need for telemedicine infrastructure, and the role of Internet access in providing connections to families in communities of origin. We describe existing efforts that have been implemented in North Carolina to raise awareness among public health and health promotion practitioners and researchers. The current coronavirus pandemic demands the attention of medical libraries, public health practitioners, and policy makers to address the digital divide for farmworkers and their families.
AD  - leejose14@ecu.edu, Associate Professor, Department of Health Education and Promotion, East Carolina University, Greenville, NC.
celeprev@ncsu.edu, Teaching Associate Professor, Department of Applied Ecology, North Carolina State University and North Carolina Agromedicine Institute, Raleigh, NC.
elharwel@ncsu.edu, Research Assistant, Department of Applied Ecology, North Carolina State University, Raleigh, NC.
blossj19@ecu.edu, Assistant Professor, Laupus Health Sciences Library, East Carolina University, Greenville, NC.
cofiel18@ecu.edu, Assistant Professor, Department of Health Education and Promotion, East Carolina University, Greenville, NC.
melinda.wiggins@duke.edu, Executive Director, Student Action with Farmworkers, Durham, NC.
firnhaberg@ecu.edu, Assistant Professor, College of Nursing, East Carolina University, Greenville, NC.
AN  - 33013227
AU  - Lee, J. G. L.
AU  - LePrevost, C. E.
AU  - Harwell, E. L.
AU  - Bloss, J. E.
AU  - Cofie, L. E.
AU  - Wiggins, M. F.
AU  - Firnhaber, G. C.
C1  - 10/6/2020
C2  - PMC7524630
DA  - Oct 1
DB  - PubMed
DO  - 10.5195/jmla.2020.1045
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Journal of the Medical Library Association : JMLA
LA  - eng
N1  - 1558-9439
Lee, Joseph G L
Orcid: 0000-0001-9698-649x
LePrevost, Catherine E
Orcid: 0000-0001-7360-0021
Harwell, Emery L
Bloss, Jamie E
Orcid: 0000-0002-0706-7684
Cofie, Leslie E
Wiggins, Melinda F
Firnhaber, Gina C
Orcid: 0000-0003-4641-0913
Journal Article
J Med Libr Assoc. 2020 Oct 1;108(4):651-655. doi: 10.5195/jmla.2020.1045.
PY  - 2020
SN  - 1536-5050 (Print)
1536-5050
SP  - 651-655
ST  - Coronavirus pandemic highlights critical gaps in rural Internet access for migrant and seasonal farmworkers: a call for partnership with medical libraries
T2  - Journal of Medical Library Association : JMLA
TI  - Coronavirus pandemic highlights critical gaps in rural Internet access for migrant and seasonal farmworkers: a call for partnership with medical libraries
VL  - 108
ID  - 7785480
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 infection of human airway epithelium activates genetic programs that lead to progressive hyperinflammation in COVID-19 patients. Here we report on the transcriptomic response of airway epithelium to interferons and its suppression by the JAK inhibitors Baricitinib and Ruxolitinib. There is a debate on the regulation of the conventional versus the novel intronic promoter inducing the short ACE2 isoform. Through RNA-seq and ChIP-seq analyses for activating chromatin marks and Polymerase II, we define the interferon-activated intronic regulatory region. Our results also support that the conventional ACE2 promoter is controlled by interferon.Competing Interest StatementThe authors have declared no competing interest.
AU  - Lee, Hye Kyung
AU  - Jung, Olive
AU  - Hennighausen, Lothar
C1  - 10/6/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.04.325415
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.04.325415
ST  - Activation of ACE2 and interferon-stimulated transcriptomes in human airway epithelium is curbed by Janus Kinase inhibitors (preprint)
T2  - bioRxiv
TI  - Activation of ACE2 and interferon-stimulated transcriptomes in human airway epithelium is curbed by Janus Kinase inhibitors (preprint)
UR  - http://biorxiv.org/content/early/2020/10/05/2020.10.04.325415.abstract
ID  - 7788887
ER  - 

TY  - JOUR
AD  - Hong Kong Red Cross Blood Transfusion Service, Hong Kong, SAR, China.
Public Health Laboratory Centre, Centre for Health Protection, Department of Health, Hong Kong, SAR, China.
Department of Pathology, Queen Elizabeth Hospital, Hong Kong, SAR, China.
State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong.
AN  - 33015920
AU  - Lee, C. K.
AU  - Leung, J. N. S.
AU  - Cheng, P.
AU  - Lung, D. C.
AU  - To, K. K. W.
AU  - Tsang, D. N. C.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/tme.12724
DP  - NLM
ET  - 2020/10/06
J2  - Transfusion medicine (Oxford, England)
LA  - eng
N1  - 1365-3148
Lee, C K
Leung, J N S
Cheng, P
Lung, D C
To, K K W
Tsang, D N C
Letter
England
Transfus Med. 2020 Oct 4. doi: 10.1111/tme.12724.
PY  - 2020
SN  - 0958-7578
ST  - Absence of SARS-CoV-2 viraemia in a blood donor with COVID-19 post-donation
T2  - Transfusion medicine (Oxford, England)
TI  - Absence of SARS-CoV-2 viraemia in a blood donor with COVID-19 post-donation
ID  - 7785236
ER  - 

TY  - JOUR
AB  - AIMS: The coronavirus disease 2019 (Covid-19) is a widespread pandemic with an increased morbidity and mortality, especially for patients with cardiovascular diseases. Angiotensin-converting enzyme 2 (ACE2) has been identified as necessary cell entry point for SARS-CoV-2. Previous animal studies have demonstrated an increased ACE2 expression following treatment with either ACE inhibitors or angiotensin 1-receptor blockers (ACEi/ARB) that have led to a massive precariousness regarding the optimal cardiovascular therapy during this pandemic. METHODS AND RESULTS: We have measured ACE2 mRNA expression using real-time qPCR in atrial biopsies of 81 patients undergoing coronary artery bypass grafting and we compared 62 patients that received ACEi/ARB versus 19 patients that were not ACEi/ARB-treated. We found atrial ACE2 mRNA expression to be significantly increased in patients treated with an ACEi or an ARB, independent from potential confounding comorbidities. Interestingly, the cardiac ACE2 mRNA expression correlated significantly with the expression in white blood cells of 22 patients encouraging further evaluation if the latter may be used as a surrogate for the former. Similarly, analysis of 18 ventricular biopsies revealed a significant and independent increase in ACE2 mRNA expression in patients with end-stage heart failure that were treated with ACEi/ARB. On the other hand, cardiac unloading with a left ventricular assist device significantly reduced ventricular ACE2 mRNA expression. CONCLUSION: Treatment with ACEi/ARB is independently associated with an increased myocardial ACE2 mRNA expression in patients with coronary artery heart disease and in patients with end-stage heart failure. Further trials are needed to test whether this association is deleterious for patients with COVID-19, or possibly protective. Nevertheless, hemodynamic factors seem to be equally important for regulation of cardiac ACE2 mRNA expression. This article is protected by copyright. All rights reserved.
AD  - Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany.
Department of Cardiothoracic Surgery, University Hospital Regensburg, Regensburg, Germany.
Department of Internal Medicine I, Klinikum St. Marien, Amberg, Germany.
AN  - 33017071
AU  - Lebek, S.
AU  - Tafelmeier, M.
AU  - Messmann, R.
AU  - Provaznik, Z.
AU  - Schmid, C.
AU  - Maier, L. S.
AU  - Birner, C.
AU  - Arzt, M.
AU  - Wagner, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/ejhf.2020
DP  - NLM
ET  - 2020/10/06
J2  - European journal of heart failure
KW  - ACE inhibitor
Ace2
COVID-19 pandemic
Lvad
SARS-CoV-2
heart failure
LA  - eng
N1  - 1879-0844
Lebek, S
Tafelmeier, M
Messmann, R
Provaznik, Z
Schmid, C
Maier, L S
Birner, C
Arzt, M
Wagner, S
Orcid: 0000-0002-9471-1166
Journal Article
England
Eur J Heart Fail. 2020 Oct 5. doi: 10.1002/ejhf.2020.
PY  - 2020
SN  - 1388-9842
ST  - ACE inhibitor/angiotensin II receptor blocker treatment and hemodynamic factors are associated with increased cardiac mRNA expression of ACE2 in patients with cardiovascular disease
T2  - European journal of heart failure
TI  - ACE inhibitor/angiotensin II receptor blocker treatment and hemodynamic factors are associated with increased cardiac mRNA expression of ACE2 in patients with cardiovascular disease
ID  - 7785164
ER  - 

TY  - JOUR
AB  - The current COVID-19 pandemic is the most severe pandemic of the 21st century, on track to having a rising death toll. Beyond causing respiratory distress, COVID-19 may also cause mortality by way of suicide. The pathways by which emerging viral disease outbreaks (EVDOs) and suicide are related are complex and not entirely understood. We aimed to systematically review the evidence on the association between EVDOs and suicidal behaviors and/or ideation. An electronic search was conducted using five databases: Medline, Embase, Web of Science, PsycINFO and Scopus in April 2020. A rapid systematic review was carried out, which involved separately and independently extracting quantitative data of selected articles. The electronic search yielded 2480 articles, of which 9 met the inclusion criteria. Most of the data were collected in Hong Kong (n�?�?) and the USA (n�?�?). Four studies reported a slight but significant increase in deaths by suicide during EVDOs. The increase in deaths by suicide was mainly reported during the peak epidemic and in older adults. Psychosocial factors such as the fear of being infected by the virus or social isolation related to quarantine measures were the most prominent factors associated with deaths by suicide during EVDOs. Overall, we found scarce and weak evidence for an increased risk of deaths by suicide during EVDOs. Our results inform the need to orient public health policies toward suicide prevention strategies targeting the psychosocial effects of EVDOs. High-quality research on suicide risk and prevention are warranted during the current pandemic.
AD  - Centre Hospitalier Le Vinatier, Bron, France; INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response - PSYR2 Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France. Electronic address: edouard.leaune@ch-le-vinatier.fr.
Centre Hospitalier Le Vinatier, Bron, France; University Lyon 1, Villeurbanne F-69000, France.
University of Southern California, Los Angeles, CA, USA.
Centre Hospitalier Le Vinatier, Bron, France; INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response - PSYR2 Team, Lyon F-69000, France; University Lyon 1, Villeurbanne F-69000, France; Department of Emergency Psychiatry, University Hospital Edouard Herriot, Hospices civils de Lyon, Lyon, France.
Centre Hospitalier Le Vinatier, Bron, France; INSERM, U1028; CNRS, UMR5292; Lyon Neuroscience Research Center, Psychiatric Disorders: from Resistance to Response - PSYR2 Team, Lyon F-69000, France.
AN  - 33017599
AU  - Leaune, E.
AU  - Samuel, M.
AU  - Oh, H.
AU  - Poulet, E.
AU  - Brunelin, J.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.ypmed.2020.106264
DP  - NLM
ET  - 2020/10/06
J2  - Preventive medicine
LA  - eng
N1  - 1096-0260
Leaune, Edouard
Samuel, Maeva
Oh, Hans
Poulet, Emmanuel
Brunelin, Jérôme
Journal Article
Review
United States
Prev Med. 2020 Oct 2:106264. doi: 10.1016/j.ypmed.2020.106264.
PY  - 2020
SN  - 0091-7435
SP  - 106264
ST  - Suicidal behaviors and ideation during emerging viral disease outbreaks before the COVID-19 pandemic: A systematic rapid review
T2  - Preventive medicine
TI  - Suicidal behaviors and ideation during emerging viral disease outbreaks before the COVID-19 pandemic: A systematic rapid review
ID  - 7785128
ER  - 

TY  - JOUR
AB  - A growing body of literature recognises the profound impact of adversity on mental health outcomes for people living in rural and remote areas. With the cumulative effects of persistent drought, record-breaking bushfires, limited access to quality health services, the COVID-19 pandemic and ongoing economic and social challenges, there is much to understand about the impact of adversity on mental health and wellbeing in rural populations. In this conceptual paper, we aim to review and adapt our existing understanding of rural adversity. We undertook a wide-ranging review of the literature, sought insights from multiple disciplines and critically developed our findings with an expert disciplinary group from across Australia. We propose that rural adversity be understood using a rural ecosystem lens to develop greater clarity around the dimensions and experiences of adversity, and to help identify the opportunities for interventions. We put forward a dynamic conceptual model of the impact of rural adversity on mental health and wellbeing, and close with a discussion of the implications for policy and practice. Whilst this paper has been written from an Australian perspective, it has implications for rural communities internationally.
AD  - Centre for Rural and Remote Mental Health, University of Newcastle, Orange, NSW 2800, Australia.
Social Innovation Research Institute, Swinburne University of Technology, Hawthorn, VIC 3122, Australia.
School of Rural Health, University of Sydney, Orange, NSW 2800, Australia.
School of Nursing, Faculty of Health and Social Development, University of British Columbia, Kelowna, BC V1V 1V7, Canada.
Centre for Mental Health Research, Australian National University, Acton, ACT 2601, Australia.
AN  - 33019735
AU  - Lawrence-Bourne, J.
AU  - Dalton, H.
AU  - Perkins, D.
AU  - Farmer, J.
AU  - Luscombe, G.
AU  - Oelke, N.
AU  - Bagheri, N.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/ijerph17197205
DP  - NLM
ET  - 2020/10/07
IS  - 19
J2  - International journal of environmental research and public health
KW  - community wellbeing
intersectionality
rural adversity
rural communities
rural mental health
rural theory
rurality
social determinants
LA  - eng
N1  - 1660-4601
Lawrence-Bourne, Joanne
Orcid: 0000-0001-9819-7398
Dalton, Hazel
Orcid: 0000-0002-5816-4548
Perkins, David
Orcid: 0000-0001-9739-7339
Farmer, Jane
Luscombe, Georgina
Oelke, Nelly
Orcid: 0000-0002-1666-5360
Bagheri, Nasser
Journal Article
Switzerland
Int J Environ Res Public Health. 2020 Oct 1;17(19):E7205. doi: 10.3390/ijerph17197205.
PY  - 2020
SN  - 1660-4601
ST  - What Is Rural Adversity, How Does It Affect Wellbeing and What Are the Implications for Action?
T2  - International journal of environmental research and public health
TI  - What Is Rural Adversity, How Does It Affect Wellbeing and What Are the Implications for Action?
VL  - 17
ID  - 7785088
ER  - 

TY  - JOUR
AB  - AIMS: To determine if the frequency of severe diabetic ketoacidosis at presentation of new-onset type 1 diabetes to an Australian tertiary centre increased during the initial period of restrictions resulting from the COVID-19 pandemic (March to May 2020). METHODS: Data were collected on presentations of newly diagnosed type 1 diabetes as well as on all presentations to the emergency department of a tertiary centre between 2015 and 2020. Data from the period of initial COVID restrictions in Australia (March to May 2020) were compared to the period March to May of the previous 5 years (pre-pandemic periods). RESULTS: The number of new diagnoses of type 1 diabetes was comparable in the pandemic period and pre-pandemic periods (11 in 2020 vs range 6-10 in 2015-2019). The frequency of severe diabetic ketoacidosis was significantly higher in the pandemic period compared to the pre-pandemic periods (45% vs 5%; P 0.003), odds ratio 16.7 (95% CI 2.0, 194.7). The overall frequency of diabetic ketoacidosis was also significantly higher during the pandemic period (73% vs 26%; P 0.007), odds ratio 7.5 (95% CI 1.7, 33.5). None of the individuals tested positive for COVID-19. Presentations of people aged 18 years to the emergency department decreased by 27% in the pandemic period compared to the average of the pre-pandemic periods (4799 vs 6550; range 6268 to 7131). CONCLUSIONS: A significant increase in the frequency of severe diabetic ketoacidosis at presentation of type 1 diabetes was observed during the initial period of COVID-19 restrictions. We hypothesize that concern about presenting to hospital during a pandemic led to a delay in diagnosis. These data have important implications for advocacy of seeking healthcare for non-pandemic-related conditions during a global pandemic.
AD  - John Hunter Children's Hospital, Australia.
School of Medicine and Public Health, University of Newcastle, Australia.
Hunter Medical Research Institute, Australia.
School of Mathematical and Physical Sciences/Statistics, University of Newcastle, Newcastle, NSW, Australia.
AN  - 33020999
AU  - Lawrence, C.
AU  - Seckold, R.
AU  - Smart, C.
AU  - King, B. R.
AU  - Howley, P.
AU  - Feltrin, R.
AU  - Smith, T. A.
AU  - Roy, R.
AU  - Lopez, P.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1111/dme.14417
DP  - NLM
ET  - 2020/10/07
J2  - Diabetic medicine : a journal of the British Diabetic Association
LA  - eng
N1  - 1464-5491
Lawrence, C
Orcid: 0000-0002-0995-5714
Seckold, R
Smart, C
Orcid: 0000-0003-3104-8800
King, B R
Howley, P
Feltrin, R
Smith, T A
Roy, R
Lopez, P
Orcid: 0000-0003-0831-199x
Journal Article
England
Diabet Med. 2020 Oct 6:e14417. doi: 10.1111/dme.14417.
PY  - 2020
SN  - 0742-3071
SP  - e14417
ST  - Increased paediatric presentations of severe diabetic ketoacidosis in an Australian tertiary centre during the COVID-19 pandemic
T2  - Diabetic medicine : a journal of British Diabetic Association
TI  - Increased paediatric presentations of severe diabetic ketoacidosis in an Australian tertiary centre during the COVID-19 pandemic
ID  - 7784964
ER  - 

TY  - JOUR
AB  - About 50% of individuals infected with the novel Coronavirus (SARS-CoV-2) suffer from intestinal infection as well as respiratory infection. They shed virus in their stool. Municipal sewage systems carry the virus and its genetic remnants. These viral traces can be detected in the sewage entering a wastewater treatment plant (WTP). Such virus signals indicate community infections but not locations of the infection within the community. In this paper, we frame and formulate the problem in a way that leads to algorithmic procedures homing in on locations and/or neighborhoods within the community that are most likely to have infections. Our data source is wastewater sampled and real-time tested from selected manholes. Our algorithms dynamically and adaptively develop a sequence of manholes to sample and test. The algorithms are often finished after 5 to 10 manhole samples, meaning that-in the field-the procedure can be carried out within one day. The goal is to provide timely information that will support faster more productive human testing for viral infection and thus reduce community disease spread. Leveraging the tree graph structure of the sewage system, we develop two algorithms, the first designed for a community that is certified at a given time to have zero infections and the second for a community known to have many infections. For the first, we assume that wastewater at the WTP has just revealed traces of SARS-CoV-2, indicating existence of a "Patient Zero" in the community. This first algorithm identifies the city block in which the infected person resides. For the second, we home in on a most infected neighborhood of the community, where a neighborhood is usually several city blocks. We present extensive computational results, some applied to a small New England city.
AD  - Institute for Data, Systems, and Society, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
Rotman School of Management, University of Toronto, Toronto, Canada.
Department of Civil Engineering, York University, Toronto, Canada.
AN  - 33017438
AU  - Larson, R. C.
AU  - Berman, O.
AU  - Nourinejad, M.
C1  - 10/6/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0240007
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Larson, Richard C
Berman, Oded
Nourinejad, Mehdi
Orcid: 0000-0002-6050-7263
Journal Article
United States
PLoS One. 2020 Oct 5;15(10):e0240007. doi: 10.1371/journal.pone.0240007. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0240007
ST  - Sampling manholes to home in on SARS-CoV-2 infections
T2  - PloS one
TI  - Sampling manholes to home in on SARS-CoV-2 infections
VL  - 15
ID  - 7785135
ER  - 

TY  - JOUR
AB  - As of October 2020, the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2), responsible for Coronavirus Disease 2019 (COVID-19), has infected over 33million individuals and killed over one million people worldwide. (https://coronavirus.jhu.edu/map.html accessed October 1 2020) Obesity and its complications are linked to severe forms of COVID-19, favouring an increased hospitalization and mortality rate. Despite being the gold-standard for the treatment of selected individuals with severe obesity, there is scarce information on whether or not bariatric surgery modifies the prognosis of people living with obesity in the current COVID-19 pandemic. Bel Lassen and colleagues have carried out the first study with a high number of patients in their sample, bringing light into this area of uncertainty. The authors provide evidence of the importance of diabetes itself as a risk factor for severe COVID-19.
AD  - Internal Medicine Department, General Health Check-up Unit, Cl�Tnica Universidad de Navarra, COVID-19, Team, Pamplona, Spain.
Obesity Area, Department of Endocrinology & Nutrition, Cl�Tnica Universidad de Navarra, IdiSNA, Pamplona, Spain.
CIBER Fisiopatolog�Ta de la Obesidad y Nutrici�Qn (CIBEROBN), Instituto de Salud Carlos III, Pamplona, Spain.
AN  - 33021051
AU  - Landecho, M. M. F.
AU  - Frühbeck, G.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1002/oby.23059
DP  - NLM
ET  - 2020/10/07
J2  - Obesity (Silver Spring, Md.)
LA  - eng
N1  - 1930-739x
Landecho, Mf Manuel Fortún
Orcid: 0000-0003-3234-8805
Frühbeck, Gena
Journal Article
United States
Obesity (Silver Spring). 2020 Oct 6. doi: 10.1002/oby.23059.
PY  - 2020
SN  - 1930-7381
ST  - Benefits of bariatric surgery prior to SARS CoV 2 infection in modulating the response to COVID-19
T2  - Obesity (Silver Spring, Md)
TI  - Benefits of bariatric surgery prior to SARS CoV 2 infection in modulating the response to COVID-19
ID  - 7784961
ER  - 

TY  - JOUR
AB  - SARS-CoV-2 has a zoonotic origin and was transmitted to humans via an undetermined intermediate host, leading to infections in humans and other mammals. To enter host cells, the viral spike protein (S-protein) binds to its receptor, ACE2, and is then processed by TMPRSS2. Whilst receptor binding contributes to the viral host range, S-protein:ACE2 complexes from other animals have not been investigated widely. To predict infection risks, we modelled S-protein:ACE2 complexes from 215 vertebrate species, calculated changes in the energy of the complex caused by mutations in each species, relative to human ACE2, and correlated these changes with COVID-19 infection data. We also analysed structural interactions to better understand the key residues contributing to affinity. We predict that mutations are more detrimental in ACE2 than TMPRSS2. Finally, we demonstrate phylogenetically that human SARS-CoV-2 strains have been isolated in animals. Our results suggest that SARS-CoV-2 can infect a broad range of mammals, but few fish, birds or reptiles. Susceptible animals could serve as reservoirs of the virus, necessitating careful ongoing animal management and surveillance.
AD  - Department of Applied Physics, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia.
Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.
Indian Institute of Science Education and Research, Pune, 411008, India.
UCL Genetics Institute, University College London, London, WC1E 6BT, UK.
Department of Science and Technology Studies, University College London, London, WC1E 6BT, UK.
Randall Division of Cell and Molecular Biophysics, Guy's Campus, New Hunt's House, King's College London, London, SE1 1UL, UK.
Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Oxford, OX3 OBP, UK.
Institute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK. c.orengo@ucl.ac.uk.
AN  - 33020502
AU  - Lam, S. D.
AU  - Bordin, N.
AU  - Waman, V. P.
AU  - Scholes, H. M.
AU  - Ashford, P.
AU  - Sen, N.
AU  - van Dorp, L.
AU  - Rauer, C.
AU  - Dawson, N. L.
AU  - Pang, C. S. M.
AU  - Abbasian, M.
AU  - Sillitoe, I.
AU  - Edwards, S. J. L.
AU  - Fraternali, F.
AU  - Lees, J. G.
AU  - Santini, J. M.
AU  - Orengo, C. A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1038/s41598-020-71936-5
DP  - NLM
ET  - 2020/10/07
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Lam, S D
Bordin, N
Waman, V P
Scholes, H M
Ashford, P
Sen, N
van Dorp, L
Rauer, C
Dawson, N L
Pang, C S M
Abbasian, M
Sillitoe, I
Edwards, S J L
Fraternali, F
Lees, J G
Santini, J M
Orengo, C A
BB/R009597/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/S020039/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/S016007/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/S020144/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/R01356X/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/T002735/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
BB/R014892/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom
203780/Z/16/A/WT_/Wellcome Trust/United Kingdom
104960/Z/14/Z/WT_/Wellcome Trust/United Kingdom
MR/P007597/1/Newton Fund/
PANDORA-ID NET/European and Developing Countries Clinical Trials Partnership/
Journal Article
England
Sci Rep. 2020 Oct 5;10(1):16471. doi: 10.1038/s41598-020-71936-5.
PY  - 2020
SN  - 2045-2322
SP  - 16471
ST  - SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
T2  - Scientific reports
TI  - SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals
VL  - 10
ID  - 7785024
ER  - 

TY  - JOUR
AB  - The digital divide limits opportunities for those without ready access to Internet Movement online of essential activities during COVID-19 took inadequate internet service from inconvenient to emergency/crisis for many households A negative correlation between rurality and internet speed was found at the county level, highlighting the struggle for rural areas Schools tackle challenges of providing equitable educational access by attempting to provide access for students, while even households with service available struggle to maintain sufficient speeds and/or can afford it Essential activities moved online, yet sufficient internet is an essential public service that remains unattainable for many U S households This article is protected by copyright All rights reserved
AU  - Lai, John
AU  - Widmar, Nicole Olynk
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Revisiting the Digital Divide in the COVID-19 Era
T2  - Applied Economic Perspectives and Policy
TI  - Revisiting the Digital Divide in the COVID-19 Era
UR  - https://doi.org/10.1002/aepp.13104
ID  - 7788130
ER  - 

TY  - JOUR
AU  - Lacorzana, J.
AU  - Rocha-de-Lossada, C.
AU  - Fern֙ndez-Vega-Cueto, L.
AU  - Ortiz-Pérez, S.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Conjunctivitis and COVID: The importance of early recognition by the physician
T2  - Enferm Infecc Microbiol Clin
TI  - Conjunctivitis and COVID: The importance of early recognition by the physician
UR  - https://doi.org/10.1016/j.eimc.2020.08.009
ID  - 7788176
ER  - 

TY  - JOUR
AB  - This article summarizes and shares experiences of how Thailand has managed and controlled the coronavirus disease 2019 (COVID-19) outbreaks. COVID-19, an emerging severe respiratory infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has posed an unprecedented, serious health threat to humankind. Advancements in health science enables us to recognize the syndrome and its etiology rapidly. The ability to transmit the virus before the development of symptoms makes control efforts a difficult task. However, primary preventive practices, i.e., physical/social distancing, wearing masks, hand hygiene, early detection of disease and isolation of patients, can slow down the epidemic in many countries, including Thailand. Delaying interventions could worsen the situation, but this is not the case with Thailand. It has actively deployed necessary preventive measures since the early phase of the pandemic with government leadership; the healthcare system's infrastructure has had strong public engagement and collaboration of all sectors in the country. Although there have been worrisome outbreaks, Thailand finally succeeded in controlling the epidemic within a few months using simple science-based recommendations. Shutting down economic and social activities placed a financial burden on all sectors. Yet, formal and informal supports for those with financial constraints, donations to the healthcare sectors, and innovation of safety devices emerged everywhere. In the time of crisis, there are hopes and innovations. Science, collaboration, united policies, and standard practice are universal measures for humankind to survive the challenges of threats that continuously emerge. Finally, we should always be alert and ready to deploy intensive preventive measures against new waves of epidemic promptly because it is likely that this pandemic will not end soon.
AD  - Certificate in Infectious Diseases, Assistant Professor, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand
Associate Professor, Ramathibodi School of Nursing, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Thailand
AN  - 146201506. Language: English. Entry Date: In Process. Revision Date: 20201005. Publication Type: Article. Journal Subset: Asia
AU  - Kumthom, Malathum
AU  - Porntip, Malathum
C1  - 10/6/2020
DB  - cin20
DP  - EBSCOhost
IS  - 4
N1  - Double Blind Peer Reviewed; Editorial Board Reviewed; Expert Peer Reviewed; Nursing; Peer Reviewed.
PY  - 2020
SN  - 1906-8107
SP  - 431-435
ST  - The COVID-19 Pandemic: What We Have Learned from Thai Experiences
T2  - Pacific Rim International Journal of Nursing Research
TI  - The COVID-19 Pandemic: What We Have Learned from Thai Experiences
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=146201506&site=ehost-live
VL  - 24
ID  - 7784346
ER  - 

TY  - JOUR
AU  - Kumar, Satish
AU  - Sekhar Reddy, Dandu
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Response to COVID-19 pandemic in India: How can we strengthen our response?
T2  - Indian Journal of Community Medicine
TI  - Response to COVID-19 pandemic in India: How can we strengthen our response?
UR  - https://doi.org/10.4103/ijcm.IJCM_653_20
ID  - 7788396
ER  - 

TY  - JOUR
AU  - Kumar, Jogender
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Pediatric Coronavirus Disease-19 (COVID-19): Meta-analyzing Literature Versus Natural History REPLY
T2  - Indian Pediatrics
TI  - Pediatric Coronavirus Disease-19 (COVID-19): Meta-analyzing Literature Versus Natural History REPLY
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812958
ID  - 7788111
ER  - 

TY  - JOUR
AB  - Sri Lanka has controlled the direct impact of COVID-19 well, but the restrictive measures have adversely affected services including cardiac and cancer care. The reasons are multifold, including previous traumatic experiences of the population. Bespoke solutions should be implemented in pandemics, considering the socioeconomic and psychological status of vulnerable populations.
AD  - University of Jaffna, Jaffna, Sri Lanka.
Teaching Hospital Jaffna, Jaffna, Sri Lanka.
Tellipalai Trail Cancer Hospital, Jaffna, Sri Lanka.
AN  - 33016088
AU  - Kumanan, T.
AU  - Rajasooriyar, C.
AU  - Guruparan, M.
AU  - Sreeharan, N.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1177/1010539520963626
DP  - NLM
ET  - 2020/10/06
J2  - Asia-Pacific journal of public health
KW  - cancer care
cardiac care
lockdowns
posttraumatic stress
public health
LA  - eng
N1  - 1941-2479
Kumanan, Thirunavukarasu
Orcid: 0000-0001-5735-4713
Rajasooriyar, Chrishanthi
Guruparan, Mahesan
Sreeharan, Nadarajah
Orcid: 0000-0002-4839-6804
Journal Article
China
Asia Pac J Public Health. 2020 Oct 3:1010539520963626. doi: 10.1177/1010539520963626.
PY  - 2020
SN  - 1010-5395
SP  - 1010539520963626
ST  - The Impact of COVID-19 on the Delivery of Critical Health Care: Experience From a Non-High-Income Country
T2  - Asia-Pacific journal of public health
TI  - The Impact of COVID-19 on the Delivery of Critical Health Care: Experience From a Non-High-Income Country
ID  - 7785225
ER  - 

TY  - JOUR
AB  - Bioactive peptides produced from natural sources are considered as strategic target for drug discovery. Hyperglycemia caused protein glycation alters the structure of many tissues that impairs their functions and lead complications diseases in human body. This study investigated the bioactive peptides produced from red and brown Lens culinaris that might inhibit protein glycation to prevent diabetic complications. In this study, red and brown Lens culinaris protein hydrolysates were prepared by tryptic digestion, using an enzyme/substrate ratio of 1:20 (g/g), at 37��C, 12 hr then peptide fractions 3 kDa were filtered by using ultrafiltration membranes. Protective ability against protein glycation, DPPH radical scavenging, and anti-proliferative activities (on HepG2, MCF-7, and PC3 cell lines) of peptide fractions were assayed in vitro. Results showed that glycation was inhibited by peptides from 28.1% to 68.3% in different test model. PC3 cell line was more sensitive to the peptides which showed strong anticancer activity with lower IC50 (0.96 mg/ml). Peptide fractions were sequenced by HPLC-MS-MS. Twenty eight novel peptides sequences was identified. In silico study, two peptides could be developed as a potential bioactive peptides exhibited antiglycation, antioxidant, and antiproliferative activities. PRACTICAL APPLICATIONS: Peptides are becoming an emerging source of medications with the development of new technologies. We have selected Lens Culinaris as one of the rich sources of proteins to explore novel bioactive peptides encapsulated in its seeds. Peptides fractions demonstrated protective ability against protein glycation, strong antioxidant potential, and promising antiproliferative activity. We have identified 28 novel peptides and molecular docking study revealed that some peptides showed strong binding potential to insulin receptor and ACE. Thus, these peptides might be used to manage diabetes complication as well as COVID-19 disease due to their interaction with ACE. However, those peptides needs to be further studied as a potential new drug.
AD  - Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Bioactive Natural Products Research Group, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Experimental Biochemistry Unit, King Fahd Medical Research Center, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Production of Bioproducts for Industrial Application Research Group, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
AN  - 33015836
AU  - Kuerban, A.
AU  - Al-Malki, A. L.
AU  - Kumosani, T. A.
AU  - Sheikh, R. A.
AU  - Al-Abbasi, F. A. M.
AU  - Alshubaily, F. A.
AU  - Omar Abulnaja, K.
AU  - Salama Moselhy, S.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/jfbc.13494
DP  - NLM
ET  - 2020/10/06
J2  - Journal of food biochemistry
KW  - Lens culinaris
antiglycation
antioxidant
antiproliferative
bioactive peptides
LA  - eng
N1  - 1745-4514
Kuerban, Abudukadeer
Al-Malki, Abdulrahman L
Kumosani, Taha A
Sheikh, Ryan A
Al-Abbasi, Fahad Ahmed M
Alshubaily, Fawzia A
Omar Abulnaja, Khalid
Salama Moselhy, Said
Orcid: 0000-0002-2384-3700
RG-87-130-38/King Abdulaziz University/
Journal Article
United States
J Food Biochem. 2020 Oct 4:e13494. doi: 10.1111/jfbc.13494.
PY  - 2020
SN  - 0145-8884
SP  - e13494
ST  - Identification, protein antiglycation, antioxidant, antiproliferative, and molecular docking of novel bioactive peptides produced from hydrolysis of Lens culinaris
T2  - Journal of food biochemistry
TI  - Identification, protein antiglycation, antioxidant, antiproliferative, and molecular docking of novel bioactive peptides produced from hydrolysis of Lens culinaris
ID  - 7785239
ER  - 

TY  - JOUR
AB  - Background: Effective management of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) requires large-scale testing. Collection of nasopharyngeal swab (NPS) by healthcare workers (HCW) is currently used to diagnose SARS-CoV-2, which increases the risk of transmission to HCWs. Self-administered saliva and buccal swabs are convenient, painless and safe alternative sample collection methods. Methods: A cross-sectional single centre study was conducted on 42 participants who were tested positive for SARS-CoV-2 via NPS within the past 7 days. A self-collected saliva and buccal swab and a HCW-collected NPS were obtained. Real-time polymerase chain reaction (RT-PCR) was performed and cycle threshold (CT) values were obtained. Positive percent agreement (PPA), negative percent agreement (NPA) and overall agreement (OA) were calculated for saliva and buccal swabs, as compared with NPS. Results: Among the 42 participants, 73.8% (31/42) tested positive via any one of the 3 tests. With reference to NPS, the saliva test had PPA 66.7%, NPA 91.7% and OA 69.0%. The buccal swab had PPA 56.7%, NPA 100% and OA 73.8%. Presence of symptoms improved diagnostic accuracy. There was no statistically significant association between CT values and duration of symptom onset within the first 12 days of symptoms for all three modalities. Conclusion: Self-collected saliva tests and buccal swabs have only moderate agreement with HCW-collected NPS swabs. Primary screening for SARS-CoV-2 may be performed with a saliva test or buccal swab, with a negative test warranting a confirmatory NPS to avoid false negatives. This combined strategy minimizes discomfort and reduces the risk of spread to the community and HCWs.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work was supported by the FY2020 SingHealth Duke-NUS Obstetrics &amp;amp; Gynaecology Academic Clinical Programme, SingHealth Duke-NUS COVID-19 Innovation Grant [01/FY2020/P2(C1)/01-A48]. JCKY received support from Singapore Ministry of Health National Medical Research Council CSA-SI-0008-2016.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Singhealth (CIRB Ref No 2020/2655)All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data that support the findings of this study are available on request from the corresponding author JCKY. The data are not publicly available due to them containing information that could compromise research participant privacy/consent.
AU  - Ku, Chee Wai
AU  - Durai, Shivani
AU  - Kwan, Jacqueline Q. T.
AU  - Loy, See Ling
AU  - Erwin, Christina
AU  - Ko, Karrie K. K.
AU  - Ng, Xiang Wen
AU  - Oon, Lynette
AU  - Thoon, Koh Cheng
AU  - Kalimuddin, Shirin
AU  - Chan, Jerry K. Y.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20205278
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20205278
ST  - Validation of self-collected buccal swab and saliva as a diagnostic tool for COVID-19 (preprint)
T2  - medRxiv
TI  - Validation of self-collected buccal swab and saliva as a diagnostic tool for COVID-19 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.03.20205278.abstract
ID  - 7788879
ER  - 

TY  - JOUR
AB  - BACKGROUND: Growing concerns over ethical issues in mentoring in medicine and surgery have hindered efforts to reinitiate mentoring for Palliative Care (PC) physicians following the easing of COVID-19 restrictions. Ranging from the misappropriation of mentee's work to bullying, ethical issues in mentoring are attributed to poor understanding and structuring of mentoring programs, underlining the need for a consistent approach to mentoring practices. METHODS: Given diverse practices across different settings and the employ of various methodologies, a novel approach to narrative reviews (NR)s is proposed to summarize, interpret, and critique prevailing data on novice mentoring. To overcome prevailing concerns surrounding the reproducibility and transparency of narrative reviews, the Systematic Evidenced Based Approach (SEBA) adopts a structured approach to searching and summarizing the included articles and employed concurrent content and thematic analysis that was overseen by a team of experts. RESULTS: A total of 18�?15 abstracts were reviewed, 62 full text articles evaluated and 41 articles included. Ten themes/categories were ascertained identified including Nature; Stakeholders; Relationship; Approach; Environment; Benefits; Barriers; Assessments; Theories and Definitions. CONCLUSION: By compiling and scrutinizing prevailing practice it is possible to appreciate the notion of the mentoring ecosystem which sees each mentee, mentor, and host organization brings with them their own microenvironment that contains their respective goals, abilities, and contextual considerations. Built around competency based mentoring stages, it is possible to advance a flexible yet consistent novice mentoring framework.
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Division of Supportive and Palliative Care, National Cancer Centre Singapore, Singapore.
The Palliative Care Centre for Excellence in Research and Education, Singapore.
Division of Cancer Education, National Cancer Centre Singapore, Singapore.
Palliative Care Institute Liverpool, Academic Palliative & End of Life Care Centre, University of Liverpool, Liverpool, UK.
Duke-NUS Medical School, National University of Singapore, Singapore.
Centre of Biomedical Ethics, National University of Singapore, Singapore.
National University Hospital, National University Health System, Singapore.
AN  - 33015366
AU  - Krishna, L. K. R.
AU  - Tan, L. H. E.
AU  - Ong, Y. T.
AU  - Tay, K. T.
AU  - Hee, J. M.
AU  - Chiam, M.
AU  - Chia, E. W. Y.
AU  - Sheri, K.
AU  - Tan, X. H.
AU  - Teo, Y. H.
AU  - Kow, C. S.
AU  - Mason, S.
AU  - Toh, Y. P.
C1  - 10/6/2020
C2  - PMC7517982
DA  - Jan-Dec
DB  - PubMed
DO  - 10.1177/2382120520957649
DP  - NLM
ET  - 2020/10/06
J2  - Journal of medical education and curricular development
KW  - Palliative care
medical school
medicine
mentoring
novice mentoring
palliative care education
postgraduate medicine
of interest with respect to the research, authorship, and/or publication of this
article.
LA  - eng
N1  - 2382-1205
Krishna, Lalit Kumar Radha
Orcid: 0000-0002-7350-8644
Tan, Lorraine Hui En
Orcid: 0000-0003-3390-2361
Ong, Yun Ting
Tay, Kuang Teck
Hee, Jia Min
Chiam, Min
Chia, Elisha Wan Ying
Orcid: 0000-0002-7603-2688
Sheri, Krish
Tan, Xiu Hui
Teo, Yao Hao
Orcid: 0000-0003-0439-4097
Kow, Cheryl Shumin
Orcid: 0000-0002-0809-0771
Mason, Stephen
Orcid: 0000-0002-4020-6869
Toh, Ying Pin
Journal Article
Review
J Med Educ Curric Dev. 2020 Sep 23;7:2382120520957649. doi: 10.1177/2382120520957649. eCollection 2020 Jan-Dec.
PY  - 2020
SN  - 2382-1205 (Print)
2382-1205
SP  - 2382120520957649
ST  - Enhancing Mentoring in Palliative Care: An Evidence Based Mentoring Framework
T2  - Journal of medical education and curricular development
TI  - Enhancing Mentoring in Palliative Care: An Evidence Based Mentoring Framework
VL  - 7
ID  - 7785317
ER  - 

TY  - JOUR
AB  - Tom70 is a versatile adaptor protein of 70 kDa anchored in the outer membrane of mitochondria in metazoa, fungi and amoeba. The tertiary structure was resolved for the Tom70 of yeast, showing 26 ��-helices, most of them participating in the formation of 11 tetratricopeptide repeat (TPR) motifs. Tom70 serves as a docking site for cytosolic chaperone proteins and co-chaperones and is thereby involved in the uptake of newly synthesized chaperone-bound proteins in mitochondrial biogenesis. In yeast, Tom70 additionally mediates ER-mitochondria contacts via binding to sterol transporter Lam6/Ltc1. In mammalian cells, TOM70 promotes endoplasmic reticulum (ER) to mitochondria Ca(2+) transfer by association with the inositol-1,4,5-triphosphate receptor type 3 (IP3R3). TOM70 is specifically targeted by the Bcl-2-related protein MCL-1 that acts as an anti-apoptotic protein in macrophages infected by intracellular pathogens, but also in many cancer cells. By participating in the recruitment of PINK1 and the E3 ubiquitin ligase Parkin, TOM70 can be implicated in the development of Parkinson's disease. TOM70 acts as receptor of the mitochondrial antiviral-signaling protein (MAVS) and thereby participates in the corresponding system of innate immunity against viral infections. The protein encoded by Orf9b in the genome of SARS-CoV-2 binds to TOM70, probably compromising the synthesis of type I interferons.
AD  - Institute for Biochemistry and Pathobiochemistry, Ruhr-University Bochum, 44801 Bochum, Germany.
AN  - 33019591
AU  - Kreimendahl, S.
AU  - Rassow, J.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/ijms21197262
DP  - NLM
ET  - 2020/10/07
IS  - 19
J2  - International journal of molecular sciences
KW  - Ip3r3
Lam6
Ltc1
Mavs
SARS-CoV-2
Slc25
Tom70
membrane contact sites
mitochondria
mitochondrial carrier family
mitochondrial protein import
LA  - eng
N1  - 1422-0067
Kreimendahl, Sebastian
Orcid: 0000-0002-4864-1865
Rassow, Joachim
Orcid: 0000-0002-1219-2623
RA 702/4-1/undefined span style="color:gray;font-size:10px;"undefined/span/
Journal Article
Review
Switzerland
Int J Mol Sci. 2020 Oct 1;21(19):E7262. doi: 10.3390/ijms21197262.
PY  - 2020
SN  - 1422-0067
ST  - The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity
T2  - International journal of molecular sciences
TI  - The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity
VL  - 21
ID  - 7785096
ER  - 

TY  - JOUR
AD  - School of Postgraduate Studies, International Medical University, Kuala Lumpur, Malaysia. chiasiang_93@hotmail.com.
School of Applied Sciences, University of Huddersfield, Huddersfield, United Kingdom.
School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, Australia.
AN  - 33011825
AU  - Kow, C. S.
AU  - Aldeyab, M.
AU  - Hasan, S. S.
C1  - 10/6/2020
C2  - PMC7532950
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s00228-020-03008-6
DP  - NLM
ET  - 2020/10/05
J2  - European journal of clinical pharmacology
LA  - eng
N1  - 1432-1041
Kow, Chia Siang
Orcid: 0000-0002-8186-2926
Aldeyab, Mamoon
Hasan, Syed Shahzad
Letter
Eur J Clin Pharmacol. 2020 Oct 4:1-3. doi: 10.1007/s00228-020-03008-6.
PY  - 2020
SN  - 0031-6970 (Print)
0031-6970
SP  - 1-3
ST  - Quality of adverse event reporting in clinical trials of remdesivir in patients with COVID-19
T2  - European journal of clinical pharmacology
TI  - Quality of adverse event reporting in clinical trials of remdesivir in patients with COVID-19
ID  - 7785649
ER  - 

TY  - JOUR
AB  - Background and Objectives In the absence of a vaccine or specific antiviral drugs against SARS-CoV-2 COVID-19 convalescent plasma became one of the experimental treatment options in many countries. Aim of this study was to assess the impact of different pathogen reduction technologies on the immunological properties of COVID-19 convalescent plasma. Materials and Methods In our experiment 140 doses of plasma collected by plasmapheresis from COVID-19 convalescent donors were subjected to pathogen reduction with one of three different methods: methylene blue (M), riboflavin (R), and amotosalen (A). To conduct a paired two-sample comparison each plasma dose was divided into 2 that were treated by one of these technologies. The titres of SARS-CoV2 neutralizing antibodies (NtAbs) and levels of specific immunoglobulins to RBD, S- and N- proteins of SARS-CoV-2 were measured before and after pathogen reduction. Results All methods reduced NtAbs titers significantly but not at the same grade: among units with the initial titre 80 or above, 81% of units had unchanged titres while 19% decreased by 1 step after methylene blue; 60% unchanged and 40% - decreased by 1 step after amotosalen; 43% unchanged, 67% a one-step decrease and 6% - a two-step decrease after riboflavin. Pairwise two-sample comparisons (M vs A, M vs R and A vs R) revealed the most prominent and statistically significant decrease in all studied parameters (except anti-RBD) following pathogen reduction with riboflavin. Conclusion Pathogen reduction with amotosalen and methylene blue provides the greater likelihood of preserving the immunological properties of the COVID-19 convalescent plasma compared to riboflavin.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis study was made possible in the context of Moscow Government COVID-19 Convalescent Plasma Program. Stanislav Volkovs research is partially supported by the Swedish Research Council and the Crafoord foundation.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Moscow Government Health Care DepartmentAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll the data referred to at this manuscript is available
AU  - Kostin, Alexander I.
AU  - Lundgren, Maria N.
AU  - Bulanov, Andrey Y.
AU  - Ladygina, Elena A.
AU  - Chirkova, Karina
AU  - Gintsburg, Alexander
AU  - Logunov, Denis
AU  - Dolzhikova, Inna
AU  - Shcheblyakov, Dmitry
AU  - Borovkova, Natalya V.
AU  - Godkov, Mikhail A.
AU  - Bazhenov, Alexey I.
AU  - Shustov, Valery
AU  - Bogdanova, Alina
AU  - Kamalova, Alina
AU  - Ganchin, Vladimir
AU  - Dombrovskiy, Eugene
AU  - Volkov, Stanislav
AU  - Drozdova, Nataliya E.
AU  - Petrikov, Sergey S.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205567
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205567
ST  - Impact of pathogen reduction technologies on immunological properties of the COVID-19 convalescent plasma (preprint)
T2  - medRxiv
TI  - Impact of pathogen reduction technologies on immunological properties of the COVID-19 convalescent plasma (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205567.abstract
ID  - 7788875
ER  - 

TY  - JOUR
AD  - Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA. Electronic address: kristin.kostick@bcm.edu.
Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.
Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.
Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, USA.
Parkinson's Disease and Movement Disorders Center, Neurology, Movement Disorders, Baylor College of Medicine, Houston, Texas, USA.
Movement Disorders Neuromodulation & Brain Circuit Therapeutics, Neurology, Icahn School of Medicine at Mount Sinai, Mount Sinai West, 1000 10th Avenue, Suite 10C, New York, NY, 10019, USA.
AN  - 33017673
AU  - Kostick, K.
AU  - Storch, E. A.
AU  - Zuk, P.
AU  - Jennifer Blumenthal, Barby
AU  - Torgerson, L.
AU  - Yoshor, D.
AU  - Sheth, S.
AU  - Viswanathan, A.
AU  - Tarakad, A.
AU  - Jimenez-Shahed, J.
AU  - Goodman, W.
AU  - L֙zaro-Muñoz, G.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.brs.2020.09.023
DP  - NLM
ET  - 2020/10/06
J2  - Brain stimulation
LA  - eng
N1  - 1876-4754
Kostick, Kristin
Storch, Eric A
Zuk, Peter
Jennifer-Blumenthal-Barby
Torgerson, Laura
Yoshor, Daniel
Sheth, Sameer
Viswanathan, Ashwin
Tarakad, Arjun
Jimenez-Shahed, Joohi
Goodman, Wayne
L֙zaro-Muñoz, Gabriel
Letter
United States
Brain Stimul. 2020 Oct 2:S1935-861X(20)30262-X. doi: 10.1016/j.brs.2020.09.023.
PY  - 2020
SN  - 1876-4754
ST  - Strategies to Mitigate Impacts of the COVID-19 Pandemic on Patients Treated with Deep Brain Stimulation
T2  - Brain stimulation
TI  - Strategies to Mitigate Impacts of the COVID-19 Pandemic on Patients Treated with Deep Brain Stimulation
ID  - 7785123
ER  - 

TY  - JOUR
AB  - Sarcoidosis is a rare disease characterized by granulomatous inflammation in affected organs, primarily in lungs. Neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) are easy and practical methods providing valuable information in diagnosis, severity, and prognosis of various diseases. Here, we aimed to investigate the association between NLR, PLR, and hematological parameters in sarcoidosis. The study was performed with 75 sarcoidosis patients and 92 controls. Patients�?NLR, PLR, and hematological parameters were compared with those of controls. Additionally, while differences between NLR and PLR were investigated in sarcoidosis patients, differences of extrapulmonary involvement, pulmonary hypertension (PH), and spontaneous remission between those with and without responses to treatment concerning stages were also assessed. NLR and PLR were significantly higher in sarcoidosis patients than controls. For NLR, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were found as 68, 61, 58, and 70% respectively, while sensitivity, specificity, PPV, and NPV for PLR were found as 72, 67, 63, and 74%, respectively. In sarcoidosis patients, NLR and PLR were significantly higher at stage-2 and -3 than at stage -1 and -4. There was a significant weak positive correlation between C-reactive protein (CRP) and NLR and PLR. Mean platelet volume (MPV), hemoglobin (Hgb), and mean corpuscular volume (MCV) were lower among patients than controls. A positive moderate correlation was detected between NLR and CD4/CD8 in blood, while there was a strong positive correlation between CD4/CD8 in bronchoalveolar lavage (BAL) and positive moderate correlation between PLR and CD4/CD8 in BAL. High NLR and PLR values were not significantly associated with pulmonary PH, spontaneous remission, response to treatment, and prognosis. The increase in PLR and NLR may be a guide for diagnoses of both sarcoidosis and lung parenchymal involvement. To use these entities as markers, our findings should be supported with prospective studies with larger samples.
AD  - Department of Chest Diseases, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey ; Department of Internal Medicine, Division of Hematology, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey ; Department of Chest Diseases, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey
AN  - 2448262905
AU  - Korkmaz, Celalettin
AU  - Demircioglu, Sinan
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/1696450
DP  - ProQuest Central
KW  - Medical Sciences--Respiratory Diseases
Lymphocytes
Investigations
Coronaviruses
COVID-19
LA  - English
N1  - Copyright - Copyright © 2020 Celalettin Korkmaz and Sinan Demircioglu. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
PY  - 2020
SN  - 11982241
ST  - The Association of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios and Hematological Parameters with Diagnosis, Stages, Extrapulmonary Involvement, Pulmonary Hypertension, Response to Treatment, and Prognosis in Patients with Sarcoidosis
T2  - Canadian Respiratory Journal
TI  - The Association of Neutrophil/Lymphocyte and Platelet/Lymphocyte Ratios and Hematological Parameters with Diagnosis, Stages, Extrapulmonary Involvement, Pulmonary Hypertension, Response to Treatment, and Prognosis in Patients with Sarcoidosis
UR  - https://www.proquest.com/docview/2448262905?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=The+Association+of+Neutrophil%2FLymphocyte+and+Platelet%2FLymphocyte+Ratios+and+Hematological+Parameters+with+Diagnosis%2C+Stages%2C+Extrapulmonary+Involvement%2C+Pulmonary+Hypertension%2C+Response+to+Treatment%2C+and+Prognosis+in+Patients+with+Sarcoidosis&title=Canadian+Respiratory+Journal&issn=11982241&date=2020-01-01&volume=2020&issue=&spage=&au=Korkmaz%2C+Celalettin%3BDemircioglu%2C+Sinan&isbn=&jtitle=Canadian+Respiratory+Journal&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F1696450
VL  - 2020
ID  - 7784936
ER  - 

TY  - JOUR
AB  - Last week, the Substance Abuse and Mental Health Services Administration (SAMHSA) struck back against ?members of the media and even other federal agencies who purportedly exist to protect the health of Americans,? charging that children&#039;s mental health is the agency&#039;s main reason for promoting school reopenings The Sept 29 statement by SAMHSA (https://www samhsa gov/newsroom/press-announcements/202009290204) came the day after the New York Times article (https://www nytimes com/2020/09/28/us/politics/white-house-cdc-coronavirus-schools html) revealing the federal Centers for Disease Control and Prevention&#039;s (CDC&#039;s) concerns about reopening schools
AU  - Knopf, Alison
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - SAMHSA pushes back against ‘political ploy�?criticism
T2  - Alcoholism & Drug Abuse Weekly
TI  - SAMHSA pushes back against ‘political ploy�?criticism
UR  - https://doi.org/10.1002/adaw.32850
ID  - 7788124
ER  - 

TY  - JOUR
AD  - University of Augsburg, Germany
Wits Centre for Diversity Studies, South Africa
AU  - Knaut, A.
AU  - Bargohain, R.
AU  - Steyn, M.
C1  - 10/6/2020
DB  - Scopus
IS  - 4
J2  - J. Int. Women's Stud.
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
PY  - 2020
SN  - 15398706 (ISSN)
SP  - 11-12
ST  - Organized by Dr. Sayan Dey, lecturer, yonphula centenary college, Bhutan: Gender, race and Covid-19
T2  - Journal of International Women's Studies
TI  - Organized by Dr. Sayan Dey, lecturer, yonphula centenary college, Bhutan: Gender, race and Covid-19
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091718286&partnerID=40&md5=4f422d8670a87b2dd02f559dc2523b48
VL  - 21
ID  - 7783286
ER  - 

TY  - JOUR
AD  - Sustainable Process Integration Laboratory �?SPIL, NETME Centre, FME, Brno University of Technology �?VUT Brno, Brno, Czech Republic
Department of Systems Science, Institute of High Performance Computing, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore
AU  - Kleme�Q, J. J.
AU  - Fan, Y. V.
AU  - Jiang, P.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1002/er.6007
J2  - Int. J. Energy Res.
KW  - COVID-19
emerging opportunities
energy
energy efficiency pros and cons
pandemic and post-pandemic
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
CODEN: IJERD
Correspondence Address: Kleme�Q, J.J.; Sustainable Process Integration Laboratory �?SPIL, NETME Centre, FME, Brno University of Technology �?VUT BrnoCzech Republic; email: jiri.klemes@vutbr.cz
Funding details: European Commission, EC
Funding text 1: The authors gratefully acknowledge financial support from the EU project Sustainable Process Integration Laboratory �?SPIL, funded as project No. CZ.02.1.01/0.0/0.0/15_003/0000456, by Czech Republic Operational Programme Research and Development, Education, Priority 1: Strengthening capacity for quality research.
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PY  - 2020
SN  - 0363907X (ISSN)
ST  - COVID-19 pandemic facilitating energy transition opportunities
T2  - International Journal of Energy Research
TI  - COVID-19 pandemic facilitating energy transition opportunities
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091731159&doi=10.1002%2fer.6007&partnerID=40&md5=379c6def36eb0082b354a3aa81591c99
ID  - 7783255
ER  - 

TY  - JOUR
AN  - 33020002
AU  - Klein, D. E.
AU  - Libman, R.
AU  - Kirsch, C.
AU  - Arora, R.
C1  - 10/6/2020
DA  - Jul 31
DB  - PubMed
DO  - 10.1016/j.jstrokecerebrovasdis.2020.105227
DP  - NLM
ET  - 2020/10/07
J2  - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
LA  - eng
N1  - 1532-8511
Klein, David E
Libman, Richard
Kirsch, Claudia
Arora, Rohan
Letter
United States
J Stroke Cerebrovasc Dis. 2020 Jul 31:105227. doi: 10.1016/j.jstrokecerebrovasdis.2020.105227.
PY  - 2020
SN  - 1052-3057
SP  - 105227
ST  - Author's response to Letter to the Editor: Anticoagulant approach in COVID-19 patients with cerebral venous thrombosis
T2  - Journal of stroke and cerebrovascular diseases : official journal of National Stroke Association
TI  - Author's response to Letter to the Editor: Anticoagulant approach in COVID-19 patients with cerebral venous thrombosis
ID  - 7785061
ER  - 

TY  - JOUR
AD  - The University of British Columbia; The Child and Family Research Institute; and BC Children's Hospital, Vancouver, BC, Canada.
AN  - 33017128
AU  - Kissoon, N.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1097/pcc.0000000000002549
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
LA  - eng
N1  - Kissoon, Niranjan
Journal Article
United States
Pediatr Crit Care Med. 2020 Oct;21(10):921-922. doi: 10.1097/PCC.0000000000002549.
PY  - 2020
SN  - 1529-7535 (Print)
1529-7535
SP  - 921-922
ST  - Coronavirus Disease 2019: A Tsunami of Data and a Plethora of Unanswered Questions
T2  - Pediatric critical care medicine : a journal of Society of Critical Care Medicine and World Federation of Pediatric Intensive and Critical Care Societies
TI  - Coronavirus Disease 2019: A Tsunami of Data and a Plethora of Unanswered Questions
VL  - 21
ID  - 7785161
ER  - 

TY  - JOUR
AB  - AIMS/INTRODUCTION: Amid the coronavirus disease (COVID-19) pandemic, the Japanese government declared a state of emergency and urged people to stay at home to prevent disease transmission. Herein, we investigated this emergency situation's effect on diabetes patients' lifestyle and glycemic control. MATERIALS AND METHODS: Diabetes patients who visited our hospital between April 1 and June 13, 2020, for a regular consultation were asked about changes in their physical activities and dietary habits during the state of emergency period. RESULTS: Among 168 patients, 26 (15.5%) gained �? kg; HbA1c levels were elevated or decreased by �?.2% compared to that at the last visit in 57 and 51 patients (Groups D and I), respectively. Group D patients were affected to a larger extent by changes in commuting (transition to teleworking) and closures of sport gyms than Group I patients. Increased snacks, sweets, total diet, and alcohol intake could have contributed to worsening of glucose control in Group D, whereas a healthy diet and less alcohol intake could have led to better glucose control in Group I. CONCLUSION: During the state of emergency period, decreased physical activity levels negatively affected glycemic control. However, despite changes in physical activity level, maintaining or improving dietary habits could lead to better glycemic control in diabetes patients. During this COVID-19 pandemic, more diabetes patients are likely to shift to teleworking and stay home for longer periods. Therefore, we should develop effective and feasible measures to promote exercise and dietary therapy, especially for those who engage in teleworking.
AD  - Clinical Research Center, Department of Medicine, International University of Health and Welfare, 8-10-16 Akasaka Minato, Tokyo, 107-0052 Japan. GRID: grid.411731.1. ISNI: 0000 0004 0531 3030
Department of Internal Medicine, Sanno Hospital, 8-10-16 Akasaka Minato, Tokyo, 107-0052 Japan.
AN  - 33020726
AU  - Kishimoto, M.
AU  - Ishikawa, T.
AU  - Odawara, M.
C1  - 10/6/2020
C2  - PMC7526069
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s13340-020-00467-1
DP  - NLM
ET  - 2020/10/07
J2  - Diabetology international
KW  - Covid-19
Diet
Physical activity
Stay-at-home
Teleworking
LA  - eng
N1  - Kishimoto, Miyako
Orcid: 0000-0003-3043-2720
Ishikawa, Takuya
Odawara, Masato
Journal Article
Japan
Diabetol Int. 2020 Sep 30:1-5. doi: 10.1007/s13340-020-00467-1.
PY  - 2020
SN  - 2190-1678 (Print)
2190-1678
SP  - 1-5
ST  - Behavioral changes in patients with diabetes during the COVID-19 pandemic
T2  - Diabetology international
TI  - Behavioral changes in patients with diabetes during the COVID-19 pandemic
ID  - 7784995
ER  - 

TY  - JOUR
AD  - Department of Anesthesiology, Critical Care, and Pain Management, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA. GRID: grid.239915.5. ISNI: 0000 0001 2285 8823
Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065 USA. GRID: grid.5386.8. ISNI: 000000041936877X
Department of Medicine, Infectious Diseases, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA. GRID: grid.239915.5. ISNI: 0000 0001 2285 8823
AN  - 33020700
AU  - Kirksey, M. A.
AU  - Yang, E. I.
AU  - Kuvadia, M.
AU  - Miller, A. O.
C1  - 10/6/2020
C2  - PMC7528450
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s11420-020-09789-x
DP  - NLM
ET  - 2020/10/07
J2  - HSS journal : the musculoskeletal journal of Hospital for Special Surgery
KW  - Covid-19
coronavirus
critical care
MD
and Andy O. Miller, MD, declare that they have no conflicts of interest.
LA  - eng
N1  - Kirksey, Meghan A
Orcid: 0000-0003-0284-9510
Yang, Elaine I
Kuvadia, Mausam
Miller, Andy O
Journal Article
United States
HSS J. 2020 Oct 1:1-7. doi: 10.1007/s11420-020-09789-x.
PY  - 2020
SN  - 1556-3316 (Print)
1556-3316
SP  - 1-7
ST  - Management Considerations for the COVID-19 Patient with Severe Disease: a Case Scenario and Literature Review
T2  - HSS journal : musculoskeletal journal of Hospital for Special Surgery
TI  - Management Considerations for the COVID-19 Patient with Severe Disease: a Case Scenario and Literature Review
ID  - 7785003
ER  - 

TY  - JOUR
AB  - Objectives: In Japan, the first case of coronavirus disease 2019 (COVID-19) was diagnosed on January 15, 2020 and subsequent infections rapidly increased. The Bacillus Calmette-Guérin (BCG) vaccination program is the principal element of tuberculosis control in Japan. We investigated the impact of routine infant BCG vaccination on prevention of local COVID-19 spread.Methods: Data on the prevalence of SARS-CoV-2 infection, annual routine infant BCG vaccine coverage (represented by the number of BCG vaccinations per live births), and other candidate factors in each prefecture were obtained from the official notifications database in Japan. We analysed the association of vaccine coverage with the prevalence of SARS-CoV-2 infection.Results: The BCG vaccine coverage in 1999-2002, 2004, and 2012 in five prefectures with no COVID-19 infections was significantly higher than that in five prefectures with a high prevalence of infections (Mann-Whitney U test, p0.05). The prevalence of SARS-CoV-2 infection was significantly negatively correlated with BCG vaccine coverage in 2004 and was significantly positively correlated with age groups 20-34 and 40-54 years (Spearman's rank correlation, p0.01).Conclusions: Our findings suggest that routine infant BCG vaccination coverage in young generation had a significant impact on prevention of local COVID-19 spread in Japan.
AD  - Department of Neurology, National Hospital Organization Utano National Hospital, 8 Ondoyama-Cho, Narutaki, Ukyo-Ku, Kyoto 616-8255, Japan
Kyoto MS Center, Kyoto Min-Iren Chuo Hospital, 16-1 Kasuga-Cho Nishinokyo, Nakagyo-Ku, Kyoto 604-8453, Japan
Department of Neurology, Kaikoukai Josai Hospital, 4-1 Kitahata-Cho, Nakamura-Ku, Nagoya 453-0815, Japan
AN  - 146013324. Language: English. Entry Date: In Process. Revision Date: 20200929. Publication Type: journal article. Journal Subset: Biomedical
AU  - Kinoshita, Masako
AU  - Tanaka, Masami
C1  - 10/6/2020
DB  - cin20
DO  - 10.1016/j.jinf.2020.08.013
DP  - EBSCOhost
IS  - 4
N1  - USA. NLM UID: 7908424.
PMID: NLM32795481.
PY  - 2020
SN  - 0163-4453
SP  - 625-633
ST  - Impact of Routine Infant BCG Vaccination on COVID-19
T2  - Journal of Infection
TI  - Impact of Routine Infant BCG Vaccination on COVID-19
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=146013324&site=ehost-live
VL  - 81
ID  - 7784427
ER  - 

TY  - JOUR
AD  - Department of Allergy and Clinical Immunology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, Korea.
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
Divison of Infectious Disease, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
Department of Allergy and Rheumatology, Fatima Hospital, Daegu, Korea.
Office of Hospital Information, Seoul National University Hospital, Seoul, Korea.
Department of internal medicine, Medical school of Yeungnam University, Daegu, Korea.
Department of Allergy and Clinical Immunology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, Korea.
AN  - 33012003
AU  - Kim, S.
AU  - Jung, C. G.
AU  - Lee, J. Y.
AU  - Kim, G.
AU  - Choi, S. W.
AU  - Jin, H. J.
AU  - Park, H. K.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/all.14609
DP  - NLM
ET  - 2020/10/05
J2  - Allergy
KW  - Asthma
Covid-19
SARS-CoV-2
negative conversion
prevalence
risk factor
LA  - eng
N1  - 1398-9995
Kim, Sujeong
Jung, Chang-Gyu
Lee, Ji Yeon
Kim, Gunwoo
Choi, Sae Won
Jin, Hyun Jung
Park, Han-Ki
Orcid: 0000-0002-5460-9917
Letter
Denmark
Allergy. 2020 Oct 4. doi: 10.1111/all.14609.
PY  - 2020
SN  - 0105-4538
ST  - Characterization of asthma and risk factors for delayed SARS-CoV-2 clearance in adult COVID-19 inpatients in Daegu
T2  - Allergy
TI  - Characterization of asthma and risk factors for delayed SARS-CoV-2 clearance in adult COVID-19 inpatients in Daegu
ID  - 7785632
ER  - 

TY  - JOUR
AD  - Department of Gastroenterology, Toranomon Hospital, Tokyo, Japan.
AN  - 33020948
AU  - Kikuchi, D.
AU  - Suzuki, Y.
AU  - Hoteya, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/den.13821
DP  - NLM
ET  - 2020/10/07
J2  - Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
LA  - eng
N1  - 1443-1661
Kikuchi, Daisuke
Orcid: 0000-0002-0529-7910
Suzuki, Yugo
Orcid: 0000-0001-9182-6286
Hoteya, Shu
Journal Article
Australia
Dig Endosc. 2020 Oct 5. doi: 10.1111/den.13821.
PY  - 2020
SN  - 0915-5635
ST  - Shielding method for the endoscopic procedures during the COVID-19 pandemic
T2  - Digestive endoscopy : official journal of Japan Gastroenterological Endoscopy Society
TI  - Shielding method for the endoscopic procedures during the COVID-19 pandemic
ID  - 7784967
ER  - 

TY  - JOUR
AB  - INTRODUCTION: COVID-19 disease has shocked the world by its spread and contagiousness. At this time, there is no valid vaccine and no proven drug treatment for COVID-19 patients. Current treatments are focused on Oxygenation, Cytokine Storm management, anti-inflammatory effects and antiviral therapy. Antiviral photodynamic therapy (aPDT) is based on the reaction between a photo-sensitive agent and a light source in the presence oxygen which can produce oxidative and free radical agents to damage the virus' structures.Recent studies show that nanotechnology can improve aPDT's outcome . The aim of this study was to find out the potential therapeutic effects of Nano antiviral photodynamic therapy on COVID-19. AREAS COVERED: This review evaluates Nano Antiviral Photodynamic Therapy: A Probable Biophysicochemical Management Modality in SARS-CoV-2. Data was extracted from published different studies published on PUBMED, SCOPUS and Web of Science. EXPERT OPINION: Studies indicating that aPDT and Nano based aPDT can be useful in viral pulmonary complications like Influenza, SARS-CoV and MERS, but there was no direct study on SARS-Cov-2. Recent studies showed that Nano based aPDT could relate to control of the stages of viral infections. Altogether, further investigations for application of nanomedicine in antimicrobial photodynamic inactivation are needed for COVID-19 Management.
AD  - Department of Biochemistry, Department of Photodynamic, Medical Laser Research Center, YARA Institute, ACECR , Tehran, Iran.
School of Medicine, Tehran University of Medical Sciences , Tehran, Iran.
Dental Research Center, Dental School, Hamadan University of Medical Sciences , Hamadan, Iran.
Radiation Sciences Research Center, Laser Research Center in Medical Sciences, AJA University of Medical Sciences , Tehran, Iran.
International Network for Photo Medicine and Photo Dynamic Therapy (INPMPDT), Universal Scientific Education and Research , Tehran, Iran.
AN  - 33019838
AU  - Khorsandi, K.
AU  - Fekrazad, S.
AU  - Vahdatinia, F.
AU  - Farmany, A.
AU  - Fekrazad, R.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/17425247.2021.1829591
DP  - NLM
ET  - 2020/10/07
J2  - Expert opinion on drug delivery
KW  - Antiviral Photodynamic therapy
Covid-19
Nanoparticle
Photodynamic therapy
SARS-CoV-2
Virus
LA  - eng
N1  - 1744-7593
Khorsandi, Khatereh
Fekrazad, Sepehr
Vahdatinia, Farshid
Farmany, Abbas
Fekrazad, Reza
Orcid: 0000-0001-5188-8829
Journal Article
England
Expert Opin Drug Deliv. 2020 Oct 6. doi: 10.1080/17425247.2021.1829591.
PY  - 2020
SN  - 1742-5247
ST  - Nano antiviral photodynamic therapy: A probable biophysicochemical management modality in SARS-CoV-2
T2  - Expert opinion on drug delivery
TI  - Nano antiviral photodynamic therapy: A probable biophysicochemical management modality in SARS-CoV-2
ID  - 7785084
ER  - 

TY  - JOUR
AB  - Objective: SARS-CoV-2 infection may manifest with minimal or no clinical symptoms. However, signs of infection may appear on routine imaging obtained in the care of patients with cancer. The management of patients planned for chemoradiation with asymptomatic or mildly symptomatic SARS-CoV-2 infection is uncertain. Method(s): Here, we present a case study of a mildly symptomatic patient with anal cancer diagnosed with SARS-CoV-2 from a staging PET-CT scan. Result(s): PET-CT scan for anal cancer staging demonstrated pulmonary avidity suspicious for an infectious, rather than malignant, process. In the setting of these imaging findings and new-onset anosmia, viral polymerase chain reaction was ordered and found to be positive for SARS-CoV-2. To avoid myelosuppression in the setting of active infection, planned chemoradiation was delayed until cessation of viral shedding. Conclusion(s): In the COVID-19 era, oncologists obtaining routine staging imaging should have high diagnostic suspicion for subclinical SARS-CoV-2 infection. To avoid precipitating severe pneumonia and hospitalization, multidisciplinary discussion with risk-benefit analysis is recommended before initiating immunosuppressive therapies such as chemoradiation. Copyright © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
AD  - (Khattab, Chakravarthy) Department of Radiation Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, Preston Research Building, Rm B-1003, Nashville, TN 37232-5671, United States (Sherry) Vanderbilt University School of Medicine, Nashville, TN, United States (Jessop) Division of Nuclear Medicine, Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, United States (Ciombor) Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States
M.H. Khattab, Department of Radiation Oncology, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2220 Pierce Avenue, Preston Research Building, Rm B-1003, Nashville, TN 37232-5671, United States. E-mail: mohamed.khattab@vumc.org
AN  - 2006834915
AU  - Khattab, M. H.
AU  - Sherry, A. D.
AU  - Jessop, A. C.
AU  - Ciombor, K. K.
AU  - Chakravarthy, B.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1007/s13566-020-00436-w
DP  - Ovid Technologies
KW  - Anal cancer
Cancer staging
Chemoradiation
Coronavirus
covid-19
adult
anosmia
anus cancer
bone marrow suppression
cancer patient
case report
chemoradiotherapy
clinical article
coronavirus disease 2019
female
hospitalization
human
immunosuppressive treatment
male
nonhuman
oncologist
polymerase chain reaction
positron emission tomography-computed tomography
radiotherapy
review
risk benefit analysis
Severe acute respiratory syndrome coronavirus 2
virus shedding
LA  - English
M3  - Review
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 1948-7894
1948-7908
ST  - Early detection of SARS-CoV-2 from staging PET-CT
T2  - Journal of Radiation Oncology
TI  - Early detection of SARS-CoV-2 from staging PET-CT
UR  - http://www.springer.com/medicine/oncology/journal/13566
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006834915
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1007%2Fs13566-020-00436-w&issn=1948-7894&isbn=&volume=&issue=&spage=&pages=&date=2020&title=Journal+of+Radiation+Oncology&atitle=Early+detection+of+SARS-CoV-2+from+staging+PET-CT&aulast=Khattab&pid=%3Cauthor%3EKhattab+M.H.%2CSherry+A.D.%2CJessop+A.C.%2CCiombor+K.K.%2CChakravarthy+B.%3C%2Fauthor%3E&%3CAN%3E2006834915%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
ID  - 7783113
ER  - 

TY  - JOUR
AB  - The homeschooling of my 6-year-old son during the school closures due to the pandemic outbreak of COVID-19 has become exceptionally easier when, after a few failed attempts, I decided to give willed-learning a try I have been brought up in a very different educational system, and my biggest fear was to lower my standards I thought without a fixed daily plan and a rigid curriculum, my son would waste his time, but soon I realized that my style of homeschooling is more damaging than helping After trying the willed-learning approach, his stress subsided and he became more confident and happy in his learning journey In this paper, I will share my story while drawing on the willed-learning approach by Carlo Ricci (2012) to argue that children will feel empowered when they have the freedom to choose when to learn, what to learn and how to learn
AU  - Kharazmi, Leila
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Willed Learning and Art as a Way for Young People to Express Their Feelings
T2  - Journal of Unschooling and Alternative Learning
TI  - Willed Learning and Art as a Way for Young People to Express Their Feelings
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812959
ID  - 7788110
ER  - 

TY  - JOUR
AB  - COVID-19 has led to an unprecedented reduction in demand for energy for transportation and electricity, a crash in prices and employment in the fossil fuel industries and record-breaking reductions in global carbon emissions This paper discusses whether this ?demand destruction? could spell the beginning of the end for fossil fuels or a temporary recession and the imperative to recover from the current crisis by ?building back better? and not the same as before There are encouraging signs for the renewable energy industry that could make COVID-19 a cloud with a silver lining;whether this is the case will depend not only on the technological realities and social response to the crisis but also on political will and foresight This article is protected by copyright All rights reserved
AU  - Khanna, Madhu
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19: A Cloud with a Silver Lining for Renewable Energy?
T2  - Applied Economic Perspectives and Policy
TI  - COVID-19: A Cloud with a Silver Lining for Renewable Energy?
UR  - https://doi.org/10.1002/aepp.13102
ID  - 7788129
ER  - 

TY  - JOUR
AB  - Large population studies such as the UK Biobank provide great opportunities for understanding the pathophysiology, health impact and prognostic factors associated with COVID-19, a condition that has had significant impact on almost everyone around the world We highlight the vast opportunities, challenges and limitations for research and collaboration from the UK Biobank and other large population studies in helping us better understand and manage both current and potential future pandemics
AU  - Khanji, Mohammed Y.
AU  - Aung, Nay
AU  - Chahal, C. Anwar A.
AU  - Petersen, Steffen E.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 and the UK Biobank-Opportunities and Challenges for Research and Collaboration With Other Large Population Studies
T2  - Frontiers in Cardiovascular Medicine
TI  - COVID-19 and the UK Biobank-Opportunities and Challenges for Research and Collaboration With Other Large Population Studies
UR  - https://doi.org/10.3389/fcvm.2020.00156
ID  - 7788384
ER  - 

TY  - JOUR
AB  - There is an ongoing debate about rooming-in for neonates born to mothers with COVID-19 disease. Rooming-in promotes bonding and leads to better outcomes for both mother and baby. The unprecedented nature of COVID-19 has led to practices aimed at protecting newborns but may come with risks of losing the momentum of rooming-in that has been achieved over past decade. In this pilot study, well neonates born at or near term (36 weeks gestational-age) were roomed in with their mothers who were positive for SARS-Co-V-2 infection, in a single room with infection control education according to American Academy of Pediatrics (AAP) recommendations and followed weekly through telehealth for 2 weeks after discharge. Of the 49 infants, none developed any symptoms of COVID-19. One out of 49 infants tested positive for SARS-Co-V-2 by reverse transcription polymerase chain reaction (RT-PCR) but repeat testing at 48-hours was negative. Our pilot study showed that rooming-in may be considered for term/near term infants with asymptomatic mothers with COVID19, while limiting transmission risk through infection control and education measures.
AD  - Pediatric Infectious Diseases, Department Of Pediatrics, St. Joseph's Children's Hospital, Paterson, New Jersey, United States.
Pediatric Infectious Diseases, Unity Point Health at St. Luke's Regional Medical Center and University of Iowa Carver College of Medicine, Sioux City, IA, United States.
Neonatology, Department Of Pediatrics, St. Joseph's Children's Hospital, Paterson, New Jersey, United States.
Department Of Pediatrics, St. Joseph's Children's Hospital, Paterson, New Jersey, United States.
AN  - 33015705
AU  - Kest, H.
AU  - Kaushik, A.
AU  - Skroce, L.
AU  - Bogusz, J.
AU  - Datta-Bhutada, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1093/jpids/piaa120
DP  - NLM
ET  - 2020/10/06
J2  - Journal of the Pediatric Infectious Diseases Society
KW  - Covid-19
Rooming-in
infants
LA  - eng
N1  - 2048-7207
Kest, Helen
Kaushik, Ashlesha
Skroce, Linda
Bogusz, Jaimee
Datta-Bhutada, Subhashree
Journal Article
England
J Pediatric Infect Dis Soc. 2020 Oct 5:piaa120. doi: 10.1093/jpids/piaa120.
PY  - 2020
SN  - 2048-7193
ST  - Rooming-in for well term infants born to asymptomatic mothers with COVID-19
T2  - Journal of Pediatric Infectious Diseases Society
TI  - Rooming-in for well term infants born to asymptomatic mothers with COVID-19
ID  - 7785258
ER  - 

TY  - JOUR
AD  - Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA. Electronic address: dkerr@sansum.org.
Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA.
AN  - 33010821
AU  - Kerr, D.
AU  - Glantz, N.
C1  - 10/6/2020
C2  - PMC7529400
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/s2213-8587(20)30312-0
DP  - NLM
ET  - 2020/10/05
J2  - The lancet. Diabetes & endocrinology
LA  - eng
N1  - 2213-8595
Kerr, David
Glantz, Namino
Journal Article
Lancet Diabetes Endocrinol. 2020 Oct 1:S2213-8587(20)30312-0. doi: 10.1016/S2213-8587(20)30312-0.
PY  - 2020
SN  - 2213-8587 (Print)
2213-8587
ST  - Diabetes, like COVID-19, is a wicked problem
T2  - lancet Diabetes & endocrinology
TI  - Diabetes, like COVID-19, is a wicked problem
ID  - 7785724
ER  - 

TY  - JOUR
AB  - Neonates are exposed to pain as a result of routinely applied painful procedures which in many cases are poorly managed. There are numerous non-pharmacologic interventions that could help manage procedural pain. There still a lack of evidence supporting the use of several non-pharmacologic interventions, such as facilitated tucking by parents (FTP) for neonatal pain management. A randomized controlled three-group experimental design was used to compare the effectiveness of oral dextrose water D10%W vs. FTP among neonates whose ages ranged from 24 to 48 hours. Three phases of (baseline, during, and after) heel stick procedures were videotaped. Pain responses were measured using a behavioral pain scale, as well as physiological pain responses (heart rate, respiratory rate, and oxygen saturation). A total of 135 neonates were included in the study. Both D10W and FTP groups were found to be effective in reducing behavioral scores (P=0.00). And physiological pain scores, including heart rate (P= 0.009), respiratory rate (P=0.01), and oxygen saturation (P=0.002) as compared to control group. However, immediately (20sec) after the procedure, the total pain score was significantly lower in dextrose group compared to the other two groups (m= 2.8, SD= 0.7). D10%W and FTP had pain-relieving effects as compared to control in neonates who are 38-40 �u 2 weeks of gestation and are undergoing heel stick procedure. However, an added advantage for D10%W, in these times, is reducing physical contact between neonate and parent during limited access of parent to NICUs units a s a result of COVID 19 transmission. © 2020, Advanced Scientific Research. All rights reserved.
AD  - Maternal & Child Health Department/Faculty of Nursing, Jordan University of Science & Technology (JUST), Jordan
Department of Clinical Pharmacy, Jordan University of Science & Technology, Jordan
King Abdullah University Hospital (KAUH), Irbid, 22110, Jordan
Department of child health, Al-abayt University, Irbid, 22110, Jordan
Kerala University of Health Sciences, Thrissur, Kerala, India
AU  - Kassab, M.
AU  - Nuseair, K.
AU  - Al-Qaoud, N.
AU  - Hamadneh, S.
AU  - Roy, A. N.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.31838/ijpr/2020.12.01.341
IS  - 1
J2  - Int. J. Pharm. Res.
KW  - Dextrose water (D10W)
Facilitated Tucking by Parents (FTP)
Pain
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Funding details: Jordan University of Science and Technology, JUST, 100/2015
Funding text 1: This study received a grant from the deanship research (JUST). (Project No.: 100/2015).
Funding text 2: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. IRB were provided by JUTS Human Research Ethics Committee (IRB project #: 100/2015) and funded this research. Special thanks to all nursing managers and staff at postnatal wards of the selected settings for their unwavering participation and support. We appreciate the participation of mothers and their support and assistance during the FTP.
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B, Tachibana, T., Altered nociceptive neuronal circuits after neonatal peripheral inflammation (2000) Science, 289 (5479), pp. 628-630; Carbajal, R., Annequin, D., Pain management in neonates (2004) Expert Rev Neurother, 4 (3), pp. 491-505. , G. O; Kassab, M, Almomani, A., Nuseir, K, Alhouary, A., Efficacy of Sucrose in Reducing Pain during Immunization among 10-to 18-Month-Old Infants and Young Children: A Randomized Controlled Trial (2020) Journal of Pediatric Nursing, 50 (2020), pp. e55-e61; Melzack, R., Wall, P. D., Pain mechanisms: a new theory. Science,2007;150(3699):971�?979. Benedetti F: Placebo and endogenous mechanisms of analgesia Handbook Exp Pharmacol,2007;177, 393�?13; Huang, C. M, Tung, W. S, Kuo, L. L, Ying-Ju, C., Comparison of pain responses of premature infants to the heelstick between containment and swaddling (2004) Journal of Nursing Research, 12 (1), pp. 31-40; Corff, K. E., Seideman, R., Venkataraman, P. S, Lutes, L., Yate Facilitated tucking: a nonpharmacologic comfort measure forpain in preterm neonates (1995) J Obstet Gynecol Neonatal Nurs, 24, pp. 143-147; Axelin, A., Salantera, S, Kirjavainen, J, Lehtonen, L., Oral glucose and parental holding preferable to opioid in pain management in preterm infants (2009) Clin J Pain, 25 (2), pp. 138-145; Rainville, P, Carrier, B, Hofbauer, R. K., Bushnell, M. C, Duncan, G. H., (1999) Dissociation of sensory Pain, 82 (2), pp. 159-171; Leslie, A., Marlow, N., Nonpharmacological pain relief (2006) Seminars in Neonatal Medicine, 11, pp. 246-250. , 2006;, 0; Okan, F, Coban, A, Ince, Z, Yapici, Z, Can, G., Analgesia in preterm newborns: the comparative effects of sucrose and glucose (2007) European journal of pediatrics, 166 (10), pp. 1017-1024; Kassab, M, Anabrees, J, Harrison, D, Sweet Taste Drinks Effects on Reducing Injection Pain and Associated Stress among Infants: A MetaAnalysis of Randomized Controlled Trials (2017) Open Journal of Pediatrics, 1 (1), pp. 1-10; Tsao, J. C, Evans, S, Meldrum, M, Altman, T, Zeltzer, L. K., A review of CAM for procedural pain in infancy: part I. Sucrose and non-nutritive sucking (2008) Evid Based Complement Alternat Med, 5 (4), pp. 371-381; Gaspardo, C. M, Linhares, M. B, Martinex, F. E., A eficacia da sacarose no alivio de doremneonatos: revisaosistematica da literatura (2005) J Pediatr (Rio J), 81 (6), pp. 435-442; Kassab, M, Foster, J. P, Foureur, M, Fowler, C., (2013) Sweet-tasting solutions for needle-related procedural pain infants one month to one year of age (Cochrane Review), 2, pp. 1-59; Cignacco, E, Hamers, J. P, Stoffel van Lingen, R. A., Gessler, P, McDougall, J, Nelle, M., The efficacy of non-pharmacological interventions in the management of proceduralpain in preterm and term neonates. A systematic literature review (2007) European Journal of Pain, 11 (2), pp. 139-152; Cignacco, E, Axelin, A, Stoffel LFacilitated tucking as a non-pharmacological interventionfor neonatal pain relief: is itclinically feasible? ActaPaediatr (2010), pp. 1651-2227. , Epubahead of print; Axelin, A, Lehtonen, L, Pelander, T, Salenterä, S., Mothers�?different styles of involvement in preterm infant pain care (2010) Journal of Obstetric Gynecology and Neonatal Nursing, 39, pp. 415-424; Axelin, A, Salantera, S, Lehtonen, L., Facilitated tucking by parents�?in pain management of fullterm neonates infants a randomized crossover trial (2006) Early Human Development, 82 (4), pp. 241-247; Stevens, B, McGrath, P, Gibbins, S, Beyene, J, Breau, L, Camfield, C., Determining behavioural and physiological responses to pain in infants at risk for neurological impairment (2007) Pain, 127 (1�?), pp. 94-102; Taddio, A, Goldbach, M, Ipp, M, Stevens, B, Koren, G., Effect of neonatal circumcision on pain responses during vaccination in boys (1995) The Lancet, 345 (8945), pp. 291-292; McClellan, C. B, Cohen, L. L, Joseph, K. E., Infant distress during immunization: A multimethod assessment (2003) Journal of Clinical Psychology in Medical Settings, 10 (4), pp. 231-238; Taddio, A, Katz, J, Ilersich, A. L, Koren, G., Effect of neonatal circumcision on pain response during subsequent routine vaccination (1997) The lancet, 349 (9052), pp. 599-603; Chambers, C. T, Reid, G. J, Craig, K. D, McGrath, P. J, Finley, G. A., Agreement between child and parent reports of pain (1998) The Clinical journal of pain, 14 (4), pp. 336-342; Barr, R. G., Reflection on measuring pain in infants: dissociation in responsive systems and bhonestsignalling Q (1999) Neonatal Intensive Care, 12, pp. 19-24; Ling, J. M., Quah, B. S, Rostenberghe, Van, The safety and efficacy of oral dextrose for relieving pain following venepuncture in neonates (2005) The Medical journal of Malaysia, 60 (2), pp. 140-145; Sahoo, JP, Rao, S, Nesargi, S, Ranjit, T, Ashok, C, Bhat, S., Expressed breast milk vs 25% dextrose in procedural pain in neonates: a double blind randomized controlled trial (2013) Indian Pediatr, 50 (2), pp. 203-207; Liaw, J, Yang, L, Katherine Wang, K. W, Chen, C. M, Chang, Y. C, Yin, T., Non-nutritive sucking and facilitated tucking relieve preterm infant pain during heel-stick procedures: A prospective, randomized controlled crossover trial (2012) International Journal of Nursing Studies, 49 (3), pp. 300-309; Slater, R, Cornelissen, L, Fabrizi, L, Patten, D, Yoxen, J, Worley, A, Boyd, S., Oral sucrose as an analgesic drug for procedural pain in newborn infants: a randomised controlled trial (2010) Lancet, 376 (9748), pp. 1225-1232
PY  - 2020
SN  - 09752366 (ISSN)
SP  - 2178-2186
ST  - Is facilitated tucking by parents more effective than dextrose water (10%) in reducing full-term neonatal pain during the heel-lancing procedure: A randomized controlled trial
T2  - International Journal of Pharmaceutical Research
TI  - Is facilitated tucking by parents more effective than dextrose water (10%) in reducing full-term neonatal pain during the heel-lancing procedure: A randomized controlled trial
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091717464&doi=10.31838%2fijpr%2f2020.12.01.341&partnerID=40&md5=1cecd4c158c38c1699678073476857f7
VL  - 12
ID  - 7783335
ER  - 

TY  - JOUR
AB  - Aims To determine the prevalence, level of coronavirus disease 2019 (COVID-19) risk perception attitude and preventive behavior implemented by the Latino population in the United States of America (USA). Methods This cross-sectional study was conducted between July 25 and August 25, 2020, and included asymptomatic Latino participants (n=410) with no current/previous COVID-19 within a religious community in Maryland. Participants answered a questionnaire consisting of three components: patient demographics/socioeconomic status, COVID-19 risk perception, and precautionary behavior. Additionally, a focused history taking and physical examination were performed, and nasal swabs for COVID-19 testing were obtained. Results Around 80% of our study population was 35 years and older, considerably healthy, with only about a third reporting history of chronic disease (~80%); most were females (~66%). Of our participants, 90% lived under poverty; only ~6% had made it to college. When asked about the likelihood of acquiring COVID-19, 97.3% stated they have a low risk of getting infected. However, as we asked about the risk of individuals living in their neighborhood, state, and country, the rates changed to moderate to high (78.4%, 86.3%, and 86.6%, respectively). When asked about preventive behavior, 71.2% stated they never wear masks and 85.4% mentioned they never keep social distance. Additionally, 76 (18.5%) tested positive for COVID-19, whereas 64 (84.2%) developed symptoms at follow-up, 57 (75%) were hospitalized, and 4 (5.2%) died. Conclusions Our study identified inadequate COVID-19 threat perception and lack of engagement in preventive behavior among a group of Latinos living in the USA. We believe that Latino communities across the USA are at markedly high risk of acquiring, spreading, and dying of COVID-19.
AD  - Radiology, American University of Beirut Medical Center, Beirut, LBN.
Internal Medicine, Self Researcher, Collierville, USA.
Medicine, Liaquat National Medical College, Karachi, PAK.
Medicine, University of Ottawa Heart Institute, Ottawa, CAN.
Cardiology, Massachusetts General Hospital, Boston, USA.
Medicine, King Edward Medical University, Lahore, PAK.
Infectious Diseases, Self Investigator, Greenbelt, USA.
Infectious Diseases, Hospital Aristides Fiallo Cabral, La Romana, DOM.
AN  - 33014665
AU  - Karout, L.
AU  - Serwat, A.
AU  - El Mais, H.
AU  - Kassab, M.
AU  - Khalid, F.
AU  - Ruiz Mercedes, B.
C1  - 10/6/2020
C2  - PMC7526957
DA  - Sep 29
DB  - PubMed
DO  - 10.7759/cureus.10707
DP  - NLM
ET  - 2020/10/06
IS  - 9
J2  - Cureus
KW  - asymptomatic
covid-19
latinos
risk perception
LA  - eng
N1  - 2168-8184
Karout, Lina
Serwat, Ayna
El Mais, Huda
Kassab, Mohamad
Khalid, Fatima
Ruiz Mercedes, Brisandi
Journal Article
Cureus. 2020 Sep 29;12(9):e10707. doi: 10.7759/cureus.10707.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10707
ST  - COVID-19 Prevalence, Risk Perceptions, and Preventive Behavior in Asymptomatic Latino Population: A Cross-Sectional Study
T2  - Cureus
TI  - COVID-19 Prevalence, Risk Perceptions, and Preventive Behavior in Asymptomatic Latino Population: A Cross-Sectional Study
VL  - 12
ID  - 7785376
ER  - 

TY  - JOUR
AB  - The COVID-19 outbreak like SARS and MERS would have been thought to end in China. But it has not been envisaged, spread in Iran then Italy to continental Europe and spread to America in very prevalant and in a very short time. It was thought that looking to China from Turkey was very distant story for us. When it showed that the heavy influence on Italy, gave us the idea to be our next photograph. No matter how slow the World Health Organization behaved, the fact that it declared the disease as a pandemic during this period, increased the seriousness. COVID-19, after confirmation with the PCR test, the detection of spread in the lungs with radiological imaging chest tomography is also done. Commonly presented clinical findings were characterized by fever, cough, headache and muscle weakness. Some person recovered with mild symptoms of this disease contrary to the high level of contagiousness without symptoms of this disease sign both a good and a bad condition. It is very crucial to avoid contact, to protect personal distance, to wear a mask and to pay attention to hand hygiene to prevent disease transmission from human to human. It is important for those with suspected diseases to isolate themselves, to be quarantined and to be kept under the supervision of a doctor. The screening and observation of patients with whom they have been in contact with their families for the last three days is the best way to break the chain of contamination. Teams established to filiation are working hard in our country. The number of patient cases in Turkey as of May 22, 154.500. The number of death was 4.276, with 2.8% ratio. COVID-19 case numbers and mortality rates declined with the curfew of over 65-year old people and younger than 20s. With the drugs that were used in the treatment protocol as hydroxychloroquine, favipiravir and supportive treatments, in Turkey, it is stated that the treatment was good. © 2020 Refik Saydam National Public Health Agency (RSNPHA).
AD  - Siirt University, Faculty of Health Sciences, Siirt, Turkey
Ankara Health Directorate, Public Health Services Presidency, Ankara, Turkey
AU  - Karageçili, H.
AU  - Yildirim, Z.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.5505/TurkHijyen.2020.95914
IS  - 3
J2  - Turk Hijyen Deney. Biyoloji Dergisi
KW  - COVID-19
Epidemiyoloji
Filyasyon
Pandemi
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Yildirim, Z.; Ankara Health Directorate, Public Health Services PresidencyTurkey; email: zyildirim7073@gmail.com
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Gautret, P., Lagier, J.C., Parola, P., Hoang, V.T., Meddeb, L., Mailhe, M., Hydroxychloroquine and azithromycin as a treatment of COVID-19: Results of an open-label non-randomized clinical trial (2020) Int J Antimicrob Agents, 20, p. 105949; Wu, C.-I., Postema, P.G., Arbelo, E., Behr, E.R., Bezzina, C.R., Napolitano, C., SARS-CoV-2, COVID-19 and inherited arrhythmia syndromes (2020) Hear Rhythm, 31. , S1547-5271(20)30285-X; Zheng, C., Wang, J., Guo, H., Lu, Z., Ma, Y., Zhu, Y., Risk-adapted treatment strategy for COVID-19 patients (2020) Int J Infect Dis, 94, pp. 74-77; Zhu, Z., Lu, Z., Xu, T., Chen, C., Yang, G., Zha, T., Arbidol monotherapy is superior to lopinavir/ ritonavir in treating COVID-19 (2020) J Infect, 81 (1); Zhang, C., Wu, Z., Li, J.-W., Zhao, H., Wang, G.-Q., The cytokine release syndrome (CRS) of severe COVID-19 and interleukin-6 receptor (IL-6R) antagonist tocilizumab may be the key to reduce the mortality (2020) Int J Antimicrob Agents, 55 (5), p. 105954; Amrane, S., Tissot-Dupont, H., Doudier, B., Eldin, C., Hocquart, M., Mailhe, M., Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France,-January 31st to March 1st, 2020: A respiratory virus snapshot (2020) Travel Med Infect Dis, 20, p. 101632; 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Baski. Ankara. Pelikan Tip Teknik Yayincilik-Akademik Kitaplar; Bozalioğlu, S., Kiliç, N., Yildirim, Z., Baştürk, B., Kurukahvecioğlu, O., The relationship between HLA-G levels and oxidative stress parameters in patients with breast cancer (2013) Turk J Med Sci, 43 (6), pp. 870-877; Yildirim, Z., Uçgun, N.I., Yildirim, F., The role of oxidative stress and antioxidants in the pathogenesis of age-related macular degeneration (2011) Clinics (Sao Paulo), 66 (5), pp. 743-746; Uçgun, N.I., Yildirim, Z., Abbasoğlu, O.E., Özel, U., Fikret, Z.C., Bilgihan, A., Senil katarakt ilerlemesi ve askorbik asit (2005) MN Oftalmol, 12, pp. 10-12; Biswal, M., Rudramurthy, S.M., Jain, N., Shamanth, A.S., Sharma, D., Jain, K., Controlling a possible outbreak of Candida auris infection: Lessons learnt from multiple interventions (2017) J Hosp Infect, 97, pp. 363-370; Schelenz, S., Hagen, F., Rhodes, J.L., Abdolrasouli, A., Chowdhary, A., Hall, A., First hospital outbreak of the globally emerging Candida auris in a European hospital (2016) Antimicrob Resist Infect Control, 5, p. 35; http://www.promedmail.org/post/20180425.5767936, (Erişim Tarihi: 15.05. 2019)UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091722064&doi=10.5505%2fTurkHijyen.2020.95914&partnerID=40&md5=3cefe006fa735bba071db892aa0ffa7d
PY  - 2020
SN  - 03779777 (ISSN)
SP  - 355-366
ST  - Epidemiological and clinical aspects of the COVID-19 pandemic and world common experiences in treatment: Turkey experience
T2  - Turk Hijyen ve Deneysel Biyoloji Dergisi
TI  - Epidemiological and clinical aspects of the COVID-19 pandemic and world common experiences in treatment: Turkey experience
VL  - 77
ID  - 7783310
ER  - 

TY  - JOUR
AB  - This essay provides a critical observation of the South Korean government's distinctive management of COVID-19 with particular reference to the state of emergency. It reveals that the success of South Korea's handling of the pandemic is largely attributed by a majority of Western media to the efficient deployment of both information and communication technologies and Confucian collectivism, two components that seem contradictory yet not incompatible under the rubric of techno-Orientalism. Analyzing the intensification of surveillance and the rapid datafication of society, this essay argues that the current state of emergency is not a breakdown of normality but a continuation of the state of crisis and disaster that rules a developing country like South Korea. In doing so, the essay seeks to facilitate a critical discussion about a new mode of democracy in the era of pandemic that increasingly grapples with tensions between individual freedom and public health.
AD  - Jaeho Kang ( jaekang@snu.ac.kr ) is Associate Professor of Communication at Seoul National University ; Jaeho Kang ( jaekang@snu.ac.kr ) is Associate Professor of Communication at Seoul National University
AN  - 2448360908
AU  - Kang, Jaeho
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1017/S0021911820002302
DP  - ProQuest Central
IS  - 3
KW  - Literature
COVID-19
media spectacle
Orientalism
datafication
surveillance
state of emergency
Culture
Public health
Success
Democracy
Communication technology
Mass media
Deployment
Nightclubs
Collectivism
Pandemics
Society
Epidemics
Information technology
Coronaviruses
Normality
Disease transmission
South Korea
Hong Kong
Asia
United States--US
China
Huxley, Aldous (1894-1963)
Western Europe
North Korea
LA  - English
N1  - Copyright - Copyright © The Association for Asian Studies, Inc., 2020
People - Huxley, Aldous (1894-1963)
SubjectsTermNotLitGenreText - Western Europe; Hong Kong; Asia; South Korea; North Korea; United States--US; China; Huxley, Aldous (1894-1963)
PY  - 2020
SN  - 00219118
SP  - 589-598
ST  - The Media Spectacle of a Techno-City: COVID-19 and the South Korean Experience of the State of Emergency
T2  - Journal of Asian Studies
TI  - The Media Spectacle of a Techno-City: COVID-19 and the South Korean Experience of the State of Emergency
UR  - https://www.proquest.com/docview/2448360908?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=The+Media+Spectacle+of+a+Techno-City%3A+COVID-19+and+the+South+Korean+Experience+of+the+State+of+Emergency&title=The+Journal+of+Asian+Studies&issn=00219118&date=2020-08-01&volume=79&issue=3&spage=589&au=Kang%2C+Jaeho&isbn=&jtitle=The+Journal+of+Asian+Studies&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1017%2FS0021911820002302
VL  - 79
ID  - 7784919
ER  - 

TY  - JOUR
AD  - Department of Anaesthesia, St Vincent's Hospital, Darlinghurst, Sydney, Australia.
Department of Anaesthesia, Liverpool Hospital, Liverpool, Sydney, Australia.
Department of Anaesthesia, Wollongong Hospital, Wollongong, Australia.
Department of Anaesthesia, Nepean Hospital, Kingswood, Sydney, Australia.
Department of Anaesthesia, Canterbury Hospital, Campsie, Sydney, Australia.
Department of Anaesthesia, Ryde Hospital, Denistone, Sydney, Australia.
South Western Sydney Clinical School, UNSW Sydney, Liverpool, Sydney, Australia.
Ingham Institute of Applied Medical Research, Liverpool, Sydney, Australia.
St Vincent's Clinical School, UNSW Sydney, Darlinghurst, Sydney, Australia.
AN  - 33016078
AU  - Kalogeropoulos, G.
AU  - Shirvington, W. J.
AU  - Magi, K. E.
AU  - Fisher, A.
AU  - Ramirez, V.
AU  - Khoury, S.
AU  - Moi, D. K.
AU  - Ban, C. D.
AU  - Kim, J.
AU  - Chuan, A.
AU  - Ben-Menachem, E.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/0310057x20954212
DP  - NLM
ET  - 2020/10/06
J2  - Anaesthesia and intensive care
LA  - eng
N1  - Kalogeropoulos, Gregory
Shirvington, William J
Magi, Karmen E
Fisher, Angus
Ramirez, Veronica
Khoury, Shano
Moi, Daniel K
Orcid: 0000-0001-8012-7252
Ban, Caroline D
Kim, Jeff
Chuan, Alwin
Orcid: 0000-0003-4356-6525
Ben-Menachem, Erez
Orcid: 0000-0002-2429-1813
Letter
United States
Anaesth Intensive Care. 2020 Oct 4:310057X20954212. doi: 10.1177/0310057X20954212.
PY  - 2020
SN  - 0310-057X (Print)
0310-057x
SP  - 310057x20954212
ST  - A multicentre audit of COVID-19 intubations in New South Wales metropolitan hospitals
T2  - Anaesthesia and intensive care
TI  - A multicentre audit of COVID-19 intubations in New South Wales metropolitan hospitals
ID  - 7785228
ER  - 

TY  - JOUR
AD  - Division of Nursing, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Alfred Nobels Allé 23, 141 83, Huddinge, Stockholm, Sweden. Zarina.kabir@ki.se.
Division of Nursing, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Alfred Nobels Allé 23, 141 83, Huddinge, Stockholm, Sweden.
Theme Aging, Karolinska University Hospital, Huddinge, Sweden.
R&D unit, Stockholms Sjukhem, Stockholm, Sweden.
Department of Gastroenterology, Herlev and Gentofte University Hospital, Herlev, Denmark.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
AN  - 33015728
AU  - Kabir, Z. N.
AU  - Boström, A. M.
AU  - Konradsen, H.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1007/s10823-020-09415-7
DP  - NLM
ET  - 2020/10/06
J2  - Journal of cross-cultural gerontology
LA  - eng
N1  - 1573-0719
Kabir, Zarina N
Orcid: 0000-0003-0465-5701
Boström, Anne-Marie
Konradsen, Hanne
Journal Article
Netherlands
J Cross Cult Gerontol. 2020 Oct 5. doi: 10.1007/s10823-020-09415-7.
PY  - 2020
SN  - 0169-3816
ST  - In Conversation with a Frontline Worker in a Care Home in Sweden during the COVID-19 Pandemic
T2  - Journal of cross-cultural gerontology
TI  - In Conversation with a Frontline Worker in a Care Home in Sweden during the COVID-19 Pandemic
ID  - 7785253
ER  - 

TY  - JOUR
AU  - Juli֙n-Jiménez, Agust�Tn
AU  - Garc�Ta, Dar�To Eduardo
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 5
LA  - es
PY  - 2020
SP  - 307-308
ST  - Acerca de c�Qmo los servicios de urgencias españoles hicieron frente a la primera oleada de pacientes durante la pandemia COVID-19
T2  - Emergencias
TI  - Acerca de c�Qmo los servicios de urgencias españoles hicieron frente a la primera oleada de pacientes durante la pandemia COVID-19
TT  - Acerca de c�Qmo los servicios de urgencias españoles hicieron frente a la primera oleada de pacientes durante la pandemia COVID-19.
On how Spanish hospital emergency departments coped with the first wave of patients during the COVID-19 pandemic.
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813019
VL  - 32
ID  - 7788455
ER  - 

TY  - JOUR
AB  - Summary This article presents a high-level synthesis implementation of the longest common subsequence (LCS) algorithm combined with a weighted-based scheduler for comparing biological sequences prioritizing energy consumption or execution time The LCS algorithm has been thoroughly tailored using Vivado High-Level Synthesis tool, which is able to synthesize register transfer level (RTL) from high-level language descriptions, such as C/C++ Performance and energy consumption results were obtained with a CPU Intel Core i7-3770 CPU and an Alpha-Data ADM-PCIE-KU3 board that has a Xilinx Kintex UltraScale XCKU060 FPGA chip We executed a batch of 20 comparisons of sequences on 10k, 20k, and 50k sizes Our experiments showed that the energy consumption on the combined approach was significantly lower when compared to the CPU, achieving 75% energy reduction on 50k comparisons We also used the tool proposed in this article to do a case study on Covid-19, with real SARS-CoV-2 sequences, comparing their LCS scores
AU  - Jorge, Carlos A. C.
AU  - Nery, Alexandre S.
AU  - Melo, Alba C. M. A.
AU  - Goldman, Alfredo
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - A CPU-FPGA heterogeneous approach for biological sequence comparison using high-level synthesis
T2  - Concurrency and Computation: Practice and Experience
TI  - A CPU-FPGA heterogeneous approach for biological sequence comparison using high-level synthesis
UR  - https://doi.org/10.1002/cpe.6007
ID  - 7788140
ER  - 

TY  - JOUR
AB  - SARS-CoV-2, an emerging coronavirus, has spread rapidly around the world, resulting in over ten million cases and more than half a million deaths as of July 1, 2020. Effective treatments and vaccines for SARS-CoV-2 infection do not currently exist. Previous studies demonstrated that nonstructural protein 16 (nsp16) of coronavirus is an S-adenosyl methionine (SAM)-dependent 2'-O-methyltransferase (2'-O-MTase) that has an important role in viral replication and prevents recognition by the host innate immune system. In the present study, we employed structural analysis, virtual screening, and molecular simulation approaches to identify clinically investigated and approved drugs which can act as promising inhibitors against nsp16 2'-O-MTase of SARS-CoV-2. Comparative analysis of primary amino acid sequences and crystal structures of seven human CoVs defined the key residues for nsp16 2-O'-MTase functions. Virtual screening and docking analysis ranked the potential inhibitors of nsp16 from more than 4,500 clinically investigated and approved drugs. Furthermore, molecular dynamics simulations were carried out on eight top candidates, including Hesperidin, Rimegepant, Gs-9667, and Sonedenoson, to calculate various structural parameters and understand the dynamic behavior of the drug-protein complexes. Our studies provided the foundation to further test and repurpose these candidate drugs experimentally and/or clinically for COVID-19 treatment. Communicated by Ramaswamy H. Sarma.
AD  - Department of Oncology, Wayne State University School of Medicine, Detroit, MI, USA.
Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI, USA.
Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, MI, USA.
AN  - 33016237
AU  - Jiang, Y.
AU  - Liu, L.
AU  - Manning, M.
AU  - Bonahoom, M.
AU  - Lotvola, A.
AU  - Yang, Z.
AU  - Yang, Z. Q.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1080/07391102.2020.1828172
DP  - NLM
ET  - 2020/10/06
J2  - Journal of biomolecular structure & dynamics
KW  - KDKE motif
SARS-CoV-2
inhibitor
methyltransferase
molecular dynamics simulation
nsp16
virtual screening
LA  - eng
N1  - 1538-0254
Jiang, Yuanyuan
Liu, Lanxin
Manning, Morenci
Bonahoom, Madison
Lotvola, Aaron
Yang, Zhe
Yang, Zeng-Quan
Journal Article
England
J Biomol Struct Dyn. 2020 Oct 4:1-16. doi: 10.1080/07391102.2020.1828172.
PY  - 2020
SN  - 0739-1102
SP  - 1-16
ST  - Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus
T2  - Journal of biomolecular structure & dynamics
TI  - Structural analysis, virtual screening and molecular simulation to identify potential inhibitors targeting 2'-O-ribose methyltransferase of SARS-CoV-2 coronavirus
ID  - 7785211
ER  - 

TY  - JOUR
AU  - Jiang, Erica Xuewei
AU  - Liu, Will Shuo
AU  - Seltzer, Lee
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Banks, Small Businesses, Local Economy, Paycheck Protection Program, COVID-19
PY  - 2020
ST  - Intermediated Credit and Local Resilience (preprint)
T2  - SSRN
TI  - Intermediated Credit and Local Resilience (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693350
ID  - 7788908
ER  - 

TY  - JOUR
AB  - BACKGROUND: The objective of this study was to perform a seroprevalence survey on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among Danish healthcare workers to identify high risk groups. METHODS: All healthcare workers and administrative personnel at the seven hospitals, pre-hospital services and specialist practitioner clinics in the Central Denmark Region were invited to be tested by a commercial SARS-CoV-2 total antibody enzyme-linked immunosorbent assay (ELISA, Wantai Biological Pharmacy Enterprise Co., Ltd., Beijing, China). RESULTS: A total of 25,950 participants were invited. Of these, 17,971 had samples available for SARS-CoV-2 antibody testing. After adjustment for assay sensitivity and specificity, the overall seroprevalence was 3.4% (CI: 2.5%-3.8%). The seroprevalence was higher in the western part of the region than in the eastern part (11.9% vs 1.2%, difference: 10.7 percentage points, CI: 9.5-12.2). In the high prevalence area, the emergency departments had the highest seroprevalence (29.7%), while departments without patients or with limited patient contact had the lowest seroprevalence (2.2%). Among the total 668 seropositive participants, 433 (64.8%) had previously been tested for SARS-CoV-2 RNA, and 50.0% had a positive RT-PCR result. CONCLUSIONS: We found large differences in the prevalence of SARS-CoV-2 antibodies in staff working in the healthcare sector within a small geographical area of Denmark. Half of all seropositive staff had been tested positive by PCR prior to this survey. This study raises awareness of precautions which should be taken to avoid in-hospital transmission. Regular testing of healthcare workers for SARS-CoV-2 should be considered to identify areas with increased transmission.
AD  - Department of Infectious Diseases, Aarhus University Hospital, Aarhus N, Denmark.
Department of Clinical Immunology, Aarhus University Hospital, Aarhus N, Denmark.
Department of Clinical Microbiology, Aarhus University Hospital, Aarhus N, Denmark.
Danish Big Data Centre for Environment and Health (BERTHA), Aarhus University, Roskilde, Denmark.
Business Intelligence, Central Denmark Region, Aarhus N, Denmark.
Department of Occupational Medicine, Herning Regional Hospital, Herning, Denmark.
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus N, Denmark.
Department of Occupational Medicine, Aarhus University Hospital, Aarhus N, Denmark.
Department of Clinical Medicine, Aarhus University, Aarhus C, Denmark.
AN  - 33011792
AU  - Jespersen, S.
AU  - Mikkelsen, S.
AU  - Greve, T.
AU  - Kaspersen, K. A.
AU  - Tolstrup, M.
AU  - Boldsen, J. K.
AU  - Redder, J. D.
AU  - Nielsen, K.
AU  - Abildgaard, A. M.
AU  - Kolstad, H. A.
AU  - Østergaard, L.
AU  - Thomsen, M. K.
AU  - Møller, H. J.
AU  - Erikstrup, C.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1093/cid/ciaa1471
DP  - NLM
ET  - 2020/10/05
J2  - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
KW  - Covid-19
SARS-CoV-2
antibody
healthcare workers
serology
LA  - eng
N1  - 1537-6591
Jespersen, Sanne
Mikkelsen, Susan
Greve, Thomas
Kaspersen, Kathrine Agergård
Tolstrup, Martin
Boldsen, Jens Kjærgaard
Redder, Jacob Dvinge
Nielsen, Kent
Abildgaard, Anders Mønsted
Kolstad, Henrik Albert
Østergaard, Lars
Thomsen, Marianne Kragh
Møller, Holger Jon
Erikstrup, Christian
Journal Article
United States
Clin Infect Dis. 2020 Oct 3:ciaa1471. doi: 10.1093/cid/ciaa1471.
PY  - 2020
SN  - 1058-4838
ST  - SARS-CoV-2 seroprevalence survey among 17,971 healthcare and administrative personnel at hospitals, pre-hospital services, and specialist practitioners in the Central Denmark Region
T2  - Clinical infectious diseases : an official publication of Infectious Diseases Society of America
TI  - SARS-CoV-2 seroprevalence survey among 17,971 healthcare and administrative personnel at hospitals, pre-hospital services, and specialist practitioners in the Central Denmark Region
ID  - 7785653
ER  - 

TY  - JOUR
AN  - 33019951
AU  - James, J. J.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1017/dmp.2020.363
DP  - NLM
ET  - 2020/10/07
J2  - Disaster medicine and public health preparedness
LA  - eng
N1  - 1938-744x
James, James J
Journal Article
United States
Disaster Med Public Health Prep. 2020 Oct 6:1-5. doi: 10.1017/dmp.2020.363.
PY  - 2020
SN  - 1935-7893
SP  - 1-5
ST  - From COVID-19 to COVID-20: one virus, two diseases
T2  - Disaster medicine and public health preparedness
TI  - From COVID-19 to COVID-20: one virus, two diseases
ID  - 7785069
ER  - 

TY  - JOUR
AB  - The number of corona virus cases is steeply increasing day by day worldwide. According to WHO, Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infection is managed by preventing infection, detection of cases, providing supportive care, and monitoring. No specific options (antiviral, monoclonal antibody or vaccine) are available for controlling and treatment of the COVID-19 infection, Convalescent plasma (CP) therapy becomes the first available option to treat this pandemic situation according to the successful use of plasma therapy in a historical corona virus outbreak. Plasma obtained from COVID-19 recovered patients is used as prophylaxis therapy or as a therapeutic option. Plasma collection, preparation, and administration requires a proper procedure to enhance its productivity. Preparation of plasma with adequate neutralizing antibody titer becomes challenging. CP therapy may provide antiviral and immunomodulatory effect to SARS-CoV-2 infected patients by controlling overactive immune system such as cytokine storm, Th1/Th17 ratio, and hypercoagulable state. Based on the available case studies data, the administration of CP is proven to be beneficial in treating critically ill patients of SARS-CoV-2 infection. Passive antibody transfusion may reduce viral load with no severe adverse reaction and provide passive immunity against the virus. However, further well-designed clinical trials are needed to establish true clinical efficacy and safety of plasma therapy. Copyright © 2020, Global Research Online. All rights reserved.
AD  - (Jain, Haque, Bhyan, Thomas, Kumari, Hamid, Sreelakshmi, Goel, Chauhan) Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, India (Haque) Department of Clinical Pharmacology Jaypee Hospital, Noida, Uttar Pradesh, India
A. Jain, Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, India. E-mail: aashijain979@gmail.com
AN  - 2005146582
AU  - Jain, A.
AU  - Haque, I.
AU  - Bhyan, S. J.
AU  - Thomas, B.
AU  - Kumari, A.
AU  - Hamid, K.
AU  - Sreelakshmi, M.
AU  - Goel, N.
AU  - Chauhan, R.
C1  - 10/6/2020
DA  - September-October
DB  - Embase
DO  - http://dx.doi.org/10.47583/ijpsrr.2020.v64i01.029
DP  - Ovid Technologies
IS  - 1
KW  - Convalescent plasma therapy
Coronavirus (COVID-19)
Neutralizing antibody
Passive antibody therapy
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
adult
case report
clinical article
clinical trial
coronavirus disease 2019
critically ill patient
cytokine storm
drug therapy
female
human
human tissue
hypercoagulability
immune system
male
passive immunization
productivity
review
virus load
antivirus agent
convalescent plasma
LA  - English
M3  - Review
PY  - 2020
SN  - 0976-044X
SP  - 159-164
ST  - Convalescent plasma therapy: Treatment option for SARS-CoV-2 infection
T2  - International Journal of Pharmaceutical Sciences Review and Research
TI  - Convalescent plasma therapy: Treatment option for SARS-CoV-2 infection
UR  - http://globalresearchonline.net/journalcontents/v64-1/29.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005146582
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.47583%2Fijpsrr.2020.v64i01.029&issn=0976-044X&isbn=&volume=64&issue=1&spage=159&pages=159-164&date=2020&title=International+Journal+of+Pharmaceutical+Sciences+Review+and+Research&atitle=Convalescent+plasma+therapy%3A+Treatment+option+for+SARS-CoV-2+infection&aulast=Jain&pid=%3Cauthor%3EJain+A.%2CHaque+I.%2CBhyan+S.J.%2CThomas+B.%2CKumari+A.%2CHamid+K.%2CSreelakshmi+M.%2CGoel+N.%2CChauhan+R.%3C%2Fauthor%3E&%3CAN%3E2005146582%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 64
ID  - 7782994
ER  - 

TY  - JOUR
AB  - The lower limits for nursing staff—as red lines to demarcate a dangerous nursing practice—are not suitable for initiating the urgently needed trend reversal to improve staffing in nursing. The German Nursing Staff Strengthening Act sets the right framework conditions for overcoming the shortage of skilled workers by returning to full coverage of nursing staff costs, but this can only be successful if—as required by the Concerted Action on Nursing—the build-up of nursing staff is presented by a procedure for a needs-based nursing staff definition. With the nursing staff regulation PPR 2.0, the German Hospital Association, the worker’s union ver.di, and the German Nursing Council have presented a pragmatic but above all immediately usable solution that has been extensively pretested. This interim solution must now be introduced immediately and bindingly in the political process and the path for further scientific development must be initiated. Health care—not only in the current COVID-19 pandemic situation—depends to a large extent on an adequate supply of nursing staff. To also ensure this in the future is the order of the day and binding nurse staffing to a needs-based staff definition are key. © 2020, Springer Medizin Verlag GmbH, ein Teil von Springer Nature.
AD  - Department für Innere Medizin, AG Versorgungsforschung, Pflege im Krankenhaus, Universitätsmedizin Halle (Saale), Ernst-Grube-Straße 40, Halle (Saale), 06120, Germany
AU  - Jahn, P.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s00761-020-00838-y
J2  - Onkologe
KW  - Health care economics and organizations
Health planning
Health services need and demand
Personnel staffing and scheduling
Staff development
LA  - German
M3  - Review
N1  - Export Date: 6 October 2020
CODEN: ONKOF
Correspondence Address: Jahn, P.; Department für Innere Medizin, AG Versorgungsforschung, Pflege im Krankenhaus, Universitätsmedizin Halle (Saale), Ernst-Grube-Straße 40, Germany; email: patrick.jahn@uk-halle.de
References: Westerfellhaus, A., ; (2020) 4. Ad-Hoc-Stellungnahme �?Coronavirus-Pandemie: Medizinische Versorgung Und Patientennahe Forschung in Einem Adaptiven Gesundheitssystem, , https://www.leopoldina.org/uploads/tx_leopublication/2020_05_27_Stellungnahme_Corona_Gesundheitssystem.pdf, . Zugegriffen: 28. Mai 2020; Simon, M., (2018), https://www.boeckler.de/pdf/p_fofoe_WP_096_2018.pdf, Von der Unterbesetzung in der Krankenhauspflege zur bedarfsgerechten Personalausstattung | Eine kritische Analyse der aktuellen Reformpläne für die Personalbesetzung im Pflegedienst der Krankenhäuser und Vorstellung zweier Alternativmodelle, . Zugegriffen: 28. Mai 2020 (Working Paper Forschungsförderung Hans Böckler Stiftung, Nummer 096, Oktober 2018); (2016) E (2019) Handbuch Zur Kalkulation Von Behandlungskosten Version, , https://www.g-drg.de/Kalkulation2/DRG-Fallpauschalen_17b_KHG/Kalkulationshandbuch.Zugegriffen:28.Mai2020; Schreyögg, J., Milstein, R., (2016) Expertise Zur Ermittlung Des Zusammenhangs Zwischen Pflegeverhältniszahlen Und Pflegesensitiven Ergebnisparametern in Deutschland, , https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/5_Publikationen/Pflege/Berichte/Gutachten_Schreyoegg_Pflegesensitive_Fachabteilungen.pdf.Zugegriffen:28.Mai2020; Needleman, J., Nurse-staffing levels and the quality of care in hospitals (2002) N Engl J Med, 346 (22), pp. 1715-1722; Aiken, L., Implications of the California nurse staffing mandate for other states (2010) Health Serv Res, 45 (4), pp. 904-921; Augurzky, B., Bünnings, C., Dördelmann, S., Greiner, W., Hein, L., Scholz, S., Wübker, A., Die Zukunft der Pflege im Krankenhaus (2016) Heft, 104. , https://www.rwi-essen.de/media/content/pages/publikationen/rwi-materialien/rwi-materialien_104.pdf.Zugegriffen:28.Mai2020; (2017) Faktencheck �?Pflegepersonal Im Krankenhaus, , https://faktencheck-gesundheit.de/de/publikationen/publikation/did/faktencheck-pflegepersonal-im-krankenhaus/, | Internationale Empirie und Status quo in Deutschland, Bertelsmann Stiftung, Zugegriffen: 28. Mai 2020; (2020), https://www.dbfk.de/media/docs/download/Allgemein/Bericht-Umfrage-Pflegepersonaluntergrenzen-2020-05-19.pdf, Ziel erreicht? Ergebnisse einer Online-Umfrage zu Effekten der Pflegepersonaluntergrenzen im Krankenhaus, . Zugegriffen: 28. Mai 2020; Thomas, D., Reifferscheid, A., Pomorin, N., Wasem, J., (2014); (2019) Vereinbarungen Der Arbeitsgruppen 1 Bis 5, , https://www.bundesgesundheitsministerium.de/fileadmin/Dateien/3_Downloads/K/Konzertierte_Aktion_Pflege/191129_KAP_Gesamttext__Stand_11.2019_3._Auflage.pdf, Zugegriffen: 28. Mai 2020; (2020), https://www.dkgev.de/themen/personal-weiterbildung/ppr-20/, Material zur PPR 2.0, Zugegriffen: 8. Mai; Eckpunkte Zur Umsetzung Der PPR 2.0, , https://gesundheit-soziales.verdi.de/++file++5e1dbaa8322ec4d3fa916945/download/20200113_Eckpunkte_Umsetzung_PPR2.0.pdf, Zugegriffen: 28. Mai 2020
PY  - 2020
SN  - 09478965 (ISSN)
ST  - Untergrenzen oder Personalbemessung in der Pflege
T2  - Onkologe
TI  - Red lines or staffing definition in nursing
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091732781&doi=10.1007%2fs00761-020-00838-y&partnerID=40&md5=1198832bee4602490d410d69bb695383
ID  - 7783333
ER  - 

TY  - JOUR
AB  - The novel coronavirus infection has spread all over the world. With no specific drug or vaccine, the process of "drug repurposing"becomes a feasible solution. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has 80% sequence similarity with the SARS-CoV, the nuclear import inhibitor "Ivermectin"(IVM) has recently been studied as a possible treatment option for coronavirus disease-2019 (COVID-19). The article aims to provide a review on structure and immunogenicity of SARS-CoV-2, indications of IVM for viral diseases, its possible mechanism on COVID-19 with a brief discussion on IVM structure, pharmacokinetics, adverse drug reactions, drug interactions, and contraindications. Further, we made possible comparisons of IVM with solidarity trial drugs and analyzed its major advantages, limitations and gave necessary recommendations for its use in future in vivo studies in the treatment of COVID-19. Copyright © 2020 The Authors.
AD  - (Jabeen, Khader) Department of Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technological University, Hyderabad,Telangana, India (Jabeen) Department of Pharmacy Practice, Mrm College of Pharmacy, Jawaharlal Nehru Technological University, Bongloor,Telangana, India
T. Jabeen, Department of Pharmacy Practice, Bhaskar Pharmacy College, Jawaharlal Nehru Technological University, Hyderabad,Telangana, India. E-mail: talhajabeen9191@gmail.com
AN  - 2007415915
AU  - Jabeen, T.
AU  - Khader, M. A.
AU  - Jabeen, S.
C1  - 10/6/2020
DA  - August
DB  - Embase
DO  - http://dx.doi.org/10.22159/ajpcr.2020.v13i8.38357
DP  - Ovid Technologies
IS  - 8
KW  - Coronavirus disease-2019
Drug repurposing
Ivermectin
Severe acute respiratory syndrome coronavirus 2
Solidarity trial
adverse drug reaction
clinical trial
contraindication
coronavirus disease 2019
drug repositioning
drug therapy
human
immunogenicity
in vivo study
nonhuman
nuclear import
pharmacokinetics
review
side effect
vaccine
LA  - English
M3  - Review
PY  - 2020
SN  - 0974-2441
2455-3891
SP  - 21-27
ST  - A REVIEW on the ANTIPARASITIC DRUG IVERMECTIN for VARIOUS VIRAL INFECTIONS and POSSIBILITIES of USING IT for NOVEL SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2: NEW HOPE to TREAT CORONAVIRUS DISEASE-2019
T2  - Asian Journal of Pharmaceutical and Clinical Research
TI  - A REVIEW on the ANTIPARASITIC DRUG IVERMECTIN for VARIOUS VIRAL INFECTIONS and POSSIBILITIES of USING IT for NOVEL SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2: NEW HOPE to TREAT CORONAVIRUS DISEASE-2019
UR  - https://innovareacademics.in/journals/index.php/ajpcr/article/view/38357
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007415915
VL  - 13
ID  - 7782944
ER  - 

TY  - JOUR
AB  - COVID-19 pandemic has had a profound impact on the delivery of medical education, training and examination schedule across the world both at undergraduate and at postgraduate (PG) levels. The novel coronavirus SARS-CoV-2 outbreak has resulted in the cancellation of traditional in-person meetings and clinical examination assessments, learning and education activities because of concern of viral transmission. Various medical universities, Royal Medical and Surgical Colleges in the UK have suspended delivery of qualifying examinations until they can be resumed safely with updated social distancing guidelines. This article evaluates the role and the possibility of virtual PG practical examination template based on authors' own recent experience of conducting successful virtual practical PG orthopaedic qualifying examinations during the COVID-19 pandemic in New Delhi, India. Advances in telecommunication technology can enable academic institution and orthopaedic educators to develop such a model and act as a blueprint for the future.
AD  - Department of Orthopaedics, Southport and Ormskirk NHS Trust, Southport, UK.
Department of Orthopaedics, Atal Bihari Vajpaee Institute of Medical Sciences, New Delhi, India drvijayortho@gmail.com.
Orthopaedics, Indraprastha Apollo Hospital, New Delhi, India.
AN  - 33011681
AU  - Iyengar, K. P.
AU  - Jain, V. K.
AU  - Vaishya, R.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1136/postgradmedj-2020-138726
DP  - NLM
ET  - 2020/10/05
J2  - Postgraduate medical journal
KW  - Medical education & training
LA  - eng
N1  - 1469-0756
Iyengar, Karthikeyan P
Orcid: 0000-0002-4379-1266
Jain, Vijay Kumar
Orcid: 0000-0003-4164-7380
Vaishya, Raju
Journal Article
England
Postgrad Med J. 2020 Oct 3:postgradmedj-2020-138726. doi: 10.1136/postgradmedj-2020-138726.
PY  - 2020
SN  - 0032-5473
ST  - Virtual postgraduate orthopaedic practical examination: a pilot model
T2  - Postgraduate medical journal
TI  - Virtual postgraduate orthopaedic practical examination: a pilot model
ID  - 7785665
ER  - 

TY  - JOUR
AB  - The pandemic of the new coronavirus infection caused by SARS-CoV-2 has forced to reconsider the methods of rehabilitation of patients with emergency conditions, including neurology. The Council of Experts of Neurologists and Rehabilitation Therapists gathered to develop unified approaches to manage stroke patients based on a discussion of practical experience and, taking into account the scientific information on COVID-19 that was available by the time of the meeting. Stroke is a serious disabling condition that requires maximum rehabilitation efforts at all stages of medical care. In the context of the SARS-CoV-2 coronavirus epidemic, the process of medical rehabilitation and the routing of patients with stroke is undergoing major changes. Combining COVID-19 and stroke requires new approaches to rehabilitation and patient management. During the meeting, a resolution was developed in which the experts formulated the tactics of medical rehabilitation of patients with stroke and COVID-19 at the first and second stages. The arguments of the importance and practicability of carrying out measures of medical rehabilitation at the third stage is given and the need to continue consultations on the indicated topic is revealed.
AD  - Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation, Moscow, Russia.
Federal Center for Brain and Neurotechnologies of the Federal Medical and Biological Agency, Moscow, Russia.
St. Petersburg Medical and Social Institute, St. Petersburg, Russia.
I.P. Pavlov First St. Petersburg State Medical University of the Ministry of Health of the Russian Federation, St. Petersburg, Russia.
Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
Treatment and Rehabilitation Center of the National Medical Research Center of the Ministry of Health of the Russian Federation, Moscow, Russia.
Kazan State Medical University of the Ministry of Health of the Russian Federation, Kazan, Russia.
Almazov National Medical Research Centre of the Ministry of Health of the Russian Federation, St. Petersburg, Russia.
N.I. Pirogov National Medical and Surgical Center of the Ministry of Healthcare of the Russian Federation, Moscow, Russia.
AN  - 33016681
AU  - Ivanova, G. E.
AU  - Melnikova, E. V.
AU  - Levin, O. S.
AU  - Khatkova, S. E.
AU  - Khasanova, D. R.
AU  - Yanishevsky, S. N.
AU  - Daminov, V. D.
AU  - Vasenina, E. E.
AU  - Gurkina, M. V.
C1  - 10/6/2020
DB  - PubMed
DO  - 10.17116/jnevro202012008281
DP  - NLM
ET  - 2020/10/06
IS  - 8. Vyp. 2
J2  - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
KW  - Covid-19
acute cerebrovascular accident
medical rehabilitation
LA  - rus
N1  - Ivanova, G E
Orcid: 0000-0001-6429-1335
Melnikova, E V
Orcid: 0000-0002-2076-4062
Levin, O S
Orcid: 0000-0003-3872-5923
Khatkova, S E
Orcid: 0000-0002-3071-4712
Khasanova, D R
Orcid: 0000-0002-8825-2346
Yanishevsky, S N
Orcid: 0000-0002-6484-286x
Daminov, V D
Orcid: 0000-0001-7141-6052
Vasenina, E E
Orcid: 0000-0002-2600-0573
Gurkina, M V
Orcid: 0000-0003-1035-9220
English Abstract
Journal Article
Russia (Federation)
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(8. Vyp. 2):81-87. doi: 10.17116/jnevro202012008281.
OP  - Aktual'nye voprosy reabilitatsii patsientov s insul'tom na fone novoi koronavirusnoi infektsii (COVID-19). Rezolyutsiya Soveta ekspertov.
PY  - 2020
SN  - 1997-7298 (Print)
1997-7298
SP  - 81-87
ST  - [Current issues in the rehabilitation of stroke patients against the background of a new coronavirus infection (COVID-19). Resolution of the Council of Experts]
T2  - Zhurnal nevrologii i psikhiatrii imeni SS Korsakova
TI  - [Current issues in the rehabilitation of stroke patients against the background of a new coronavirus infection (COVID-19). Resolution of the Council of Experts]
VL  - 120
ID  - 7785186
ER  - 

TY  - JOUR
AB  - Atrial fibrillation is a frequent complication among patients with severe coronavirus disease-2019 (COVID-19) infection. Both direct and indirect mechanisms through COVID-19 have been described to explain this relationship. COVID-19 infection increases the risk of developing both arterial and venous thrombotic complications through systemic coagulation activation, leading to increased mortality. Chronic oral anticoagulation is essential to reduce the thromboembolic risk among AF patients. Switching to low-molecular-weight heparin has been recommended during hospitalization for COVID-19 infection. Of note, at discharge, the prescription of direct oral anticoagulants may offer some advantages over vitamin K antagonists. However, oral anticoagulants should only be prescribed after the consideration of drug-drug interactions with antiviral therapies as well as of the risk of hepatotoxicity, which is common among individuals with severe COVID-19 pneumonia. Not all anticoagulants have the same risk of hepatotoxicity; dabigatran has shown a good efficacy and safety profile and could have a lower risk of hepatotoxicity. Furthermore, its metabolism by cytochrome P450 is absent and it has a specific reversal agent. Therefore, dabigatran may be considered as a first-line choice for oral anticoagulation at discharge after COVID-19 infection. In this review, the available information on the antithrombotic management of AF patients at discharge after COVID-19 infection is updated. In addition, a practical algorithm, considering renal and liver function, which facilitates the anticoagulation choice at discharge is presented.
AD  - Department of Hematology, Hospital Cl�Tnico Universitario Santa Luc�Ta, Cartagena, Spain.
Laboratory Department, Hospital Cl�Tnico Universitario Santa Luc�Ta, Cartagena, Spain.
Department of Cardiology, Hospital Cl�Tnico Universitario Santa Luc�Ta, Cartagena, Spain.
Department of Pneumology, Hospital Cl�Tnico Universitario Santa Luc�Ta, Cartagena, Spain.
AN  - 33014097
AU  - Iturbe-Hernandez, T.
AU  - Garc�Ta de Guadiana Romualdo, L.
AU  - Gil Ortega, I.
AU  - Mart�Tnez Francés, A.
AU  - Meca Birlanga, O.
AU  - Cerezo-Manchado, J. J.
C1  - 10/6/2020
C2  - PMC7505118
DB  - PubMed
DO  - 10.7573/dic.2020-8-3
DP  - NLM
ET  - 2020/10/06
J2  - Drugs in context
KW  - Covid-19
atrial fibrillation
dabigatran
direct oral anticoagulants
hepatotoxicity
no conflicts of interest related to this manuscript. The International Committee of
Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the
authors is available for download at:
https://www.drugsincontext.com/wp-content/uploads/2020/09/dic.2020-8-3-COI.pdf
LA  - eng
N1  - 1740-4398
Iturbe-Hernandez, Teodoro
Garc�Ta de Guadiana Romualdo, Luis
Gil Ortega, Ignacio
Mart�Tnez Francés, Antonio
Meca Birlanga, Olga
Cerezo-Manchado, Juan José
Journal Article
Drugs Context. 2020 Sep 18;9:2020-8-3. doi: 10.7573/dic.2020-8-3. eCollection 2020.
PY  - 2020
SN  - 1745-1981 (Print)
1740-4398
ST  - Dabigatran, the oral anticoagulant of choice at discharge in patients with non-valvular atrial fibrillation and COVID-19 infection: the ANIBAL protocol
T2  - Drugs in context
TI  - Dabigatran, the oral anticoagulant of choice at discharge in patients with non-valvular atrial fibrillation and COVID-19 infection: the ANIBAL protocol
VL  - 9
ID  - 7785422
ER  - 

TY  - JOUR
AB  - COVID-19 is a novel virus that causes infection in both the upper respiratory tract and the lungs. The numbers of cases and deaths have increased on a daily basis on the scale of a global pandemic. Chest X-ray images have proven useful for monitoring various lung diseases and have recently been used to monitor the COVID-19 disease. In this paper, deep-learning-based approaches, namely deep feature extraction, fine-tuning of pretrained convolutional neural networks (CNN), and end-to-end training of a developed CNN model, have been used in order to classify COVID-19 and normal (healthy) chest X-ray images. For deep feature extraction, pretrained deep CNN models (ResNet18, ResNet50, ResNet101, VGG16, and VGG19) were used. For classification of the deep features, the Support Vector Machines (SVM) classifier was used with various kernel functions, namely Linear, Quadratic, Cubic, and Gaussian. The aforementioned pretrained deep CNN models were also used for the fine-tuning procedure. A new CNN model is proposed in this study with end-to-end training. A dataset containing 180 COVID-19 and 200 normal (healthy) chest X-ray images was used in the study's experimentation. Classification accuracy was used as the performance measurement of the study. The experimental works reveal that deep learning shows potential in the detection of COVID-19 based on chest X-ray images. The deep features extracted from the ResNet50 model and SVM classifier with the Linear kernel function produced a 94.7% accuracy score, which was the highest among all the obtained results. The achievement of the fine-tuned ResNet50 model was found to be 92.6%, whilst end-to-end training of the developed CNN model produced a 91.6% result. Various local texture descriptors and SVM classifications were also used for performance comparison with alternative deep approaches; the results of which showed the deep approaches to be quite efficient when compared to the local texture descriptors in the detection of COVID-19 based on chest X-ray images.
AD  - Sulaimani Polytechnic University, College of Informatics, Information Technology Department, Sulaymaniyah, Iraq.
Firat University, Technology Faculty, Electrical-Electronics Engineering Department, Elazig, Turkey.
AN  - 33013005
AU  - Ismael, A. M.
AU  - Şengür, A.
C1  - 10/6/2020
C2  - PMC7521412
DA  - Sep 28
DB  - PubMed
DO  - 10.1016/j.eswa.2020.114054
DP  - NLM
ET  - 2020/10/06
J2  - Expert systems with applications
KW  - Covid-19
chest X-ray images
convolutional neural networks
deep learning
local texture descriptors
LA  - eng
N1  - 0957-4174
Ismael, Aras M
Şengür, Abdulkadir
Journal Article
Expert Syst Appl. 2020 Sep 28:114054. doi: 10.1016/j.eswa.2020.114054.
PY  - 2020
SN  - 0957-4174 (Print)
0957-4174
SP  - 114054
ST  - Deep Learning Approaches for COVID-19 Detection Based on Chest X-ray Images
T2  - Expert systems with applications
TI  - Deep Learning Approaches for COVID-19 Detection Based on Chest X-ray Images
ID  - 7785512
ER  - 

TY  - JOUR
AD  - Department of Computer Science and Engineering, Military Institute of Science and Technology, Dhaka, Bangladesh.
Bangladesh Institute of Child Health, Dhaka Shishu (Children) Hospital, Dhaka, Bangladesh.
AN  - 33016099
AU  - Islam, M. N.
AU  - Zaman, A.
AU  - Sarker, S.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1177/1010539520964275
DP  - NLM
ET  - 2020/10/06
J2  - Asia-Pacific journal of public health
LA  - eng
N1  - 1941-2479
Islam, Muhammad Nazrul
Orcid: 0000-0002-7189-4879
Zaman, Akib
Sarker, Shaoli
Letter
China
Asia Pac J Public Health. 2020 Oct 3:1010539520964275. doi: 10.1177/1010539520964275.
PY  - 2020
SN  - 1010-5395
SP  - 1010539520964275
ST  - Beliefs About COVID-19 of Elderly Residents in Rural Bangladesh
T2  - Asia-Pacific journal of public health
TI  - Beliefs About COVID-19 of Elderly Residents in Rural Bangladesh
ID  - 7785222
ER  - 

TY  - JOUR
AB  - Marked differences in COVID-19 mortalities have been observed among 47 prefectures in Japan. Here, we explored associations between COVID-19 mortalities and medical and public health capacities in individual prefectures. The following data by prefecture were abstracted from open resources provided by the Ministry of Health, Labour and Welfare in Japan as of May 24, 2020: total number of COVID-19 deaths; polymerase chain reaction (PCR)-positive ratio (i.e., number of patients with PCR-positive results/number of patients aiming diagnosis of COVID-19 or individuals in close contacted with COVID-19 patients); number of call centers, outpatient centers, and hospital beds specifically for patients diagnosed with COVID-19; and others. The primary outcome was COVID-19 mortality per million population. Multiple and simple linear regression models were applied. Two variables were significantly associated with COVID-19 mortality: PCR-positive ratio (P  0.001) and number of critical care medical centers per million population (P = 0.001). PCR-positive ratio was positively associated with COVID-19 mortality (aR-sqr = 0.522). Low PCR-positive ratio, especially = 4%, was associated with low COVID-19 mortality. Critical care medical centers may also play an important role in reducing the risk of COVID-19 death. Copyright © 2020, The Author(s).
AD  - (Ishikawa, Hifumi) Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan (Urashima) Division of Molecular Epidemiology, The Jikei University School of Medicine, 3-19-18, Nishi-shinbashi, Minato-ku, Tokyo 105-8471, Japan
T. Hifumi, Department of Emergency and Critical Care Medicine, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo 104-8560, Japan. E-mail: hifumitoru@gmail.com
AU  - Ishikawa, Y.
AU  - Hifumi, T.
AU  - Urashima, M.
C1  - 10/6/2020
DO  - http://dx.doi.org/10.1007/s42399-020-00547-y
DP  - OviUI - 2006834957
KW  - covid-19
Mortality
Polymerase chain reaction
SARS-CoV-2
adult
article
call center
controlled study
coronavirus disease 2019
hospital bed
human
intensive care
Japan
linear regression analysis
outcome assessment
outpatient
public health
welfare
LA  - English
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 2523-8973 (electronic)
2523-8973
ST  - Critical Care Medical Centers May Play an Important Role in Reducing the Risk of COVID-19 Death in Japan
T2  - SN Comprehensive Clinical Medicine
TI  - Critical Care Medical Centers May Play an Important Role in Reducing the Risk of COVID-19 Death in Japan
UR  - https://link.springer.com/journal/volumesAndIssues/42399
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006834957
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1007%2Fs42399-020-00547-y&issn=2523-8973&isbn=&volume=&issue=&spage=&pages=&date=2020&title=SN+Comprehensive+Clinical+Medicine&atitle=Critical+Care+Medical+Centers+May+Play+an+Important+Role+in+Reducing+the+Risk+of+COVID-19+Death+in+Japan&aulast=Ishikawa&pid=%3Cauthor%3EIshikawa+Y.%2CHifumi+T.%2CUrashima+M.%3C%2Fauthor%3E&%3CAN%3E2006834957%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
ID  - 7783111
ER  - 

TY  - JOUR
AB  - The COVID-19 patients were first detected in China, in December 2019, then the novel virus with associated pneumonia and other diseases spread quickly to worldwide becoming a serious public health intimidation. Despite all the efforts, the pharmacological agents used for controlling or treating the disease, especially respiratory problems, have not been accomplished so far. Among various treatment options, mesenchymal stem cell-based cellular therapies are being investigated, because of their regeneration ability and multipotency along with other features like immunomodulation, antifibrosis and anti-inflammatory effects. This paper intends to analyze the current clinical trials on stem cell treatment of novel virus, searching and reviewing the available information and the International Clinical Trials Registry Platform (ICTRP) of World Health Organization (WHO). We concluded that the stem cell treatment of COVID-19 is found promising with pilot studies' results, but still in the early development phase. There is an urgent need for large-scale investigations to confirm and validate the safety and efficacy profile of these therapies with reliable scientific evidence.
AD  - 1Istinye University, Faculty of Medicine, Department of Histology & Embryology, Istanbul, Turkey.
2Istinye University, Stem Cell and Tissue Engineering R&D Center, Istanbul, Turkey.
3Istinye University, 3D Bioprinting Design & Prototyping R&D Center, Istanbul, Turkey.
4Liv Hospital, Stem Cell and Regenerative Therapies Center (LivMedCell), Istanbul, Turkey.
AN  - 33014531
AU  - Irmak, D. K.
AU  - Dar�\c�\, H.
AU  - Karaöz, E.
C1  - 10/6/2020
C2  - PMC7505270
DA  - Oct
DB  - PubMed
DO  - 10.14336/ad.2020.0608
DP  - NLM
ET  - 2020/10/06
IS  - 5
J2  - Aging and disease
KW  - Covid-19
Stem cell
clinical
treatment
trials
LA  - eng
N1  - 2152-5250
Irmak, Duygu Koyuncu
Dar�\c�\, Hakan
Karaöz, Erdal
Journal Article
Review
Aging Dis. 2020 Oct 1;11(5):1174-1191. doi: 10.14336/AD.2020.0608. eCollection 2020 Oct.
PY  - 2020
SN  - 2152-5250 (Print)
2152-5250
SP  - 1174-1191
ST  - Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?
T2  - Aging and disease
TI  - Stem Cell Based Therapy Option in COVID-19: Is It Really Promising?
VL  - 11
ID  - 7785390
ER  - 

TY  - JOUR
AB  - As the global impact of the COVID-19 pandemic continues to evolve, robust data describing its effect on maternal and child health (MCH) remains limited. The aim of this study was to elucidate an agenda for COVID-19 research with particular focus on its impact within MCH populations. This was achieved using the Nominal Group Technique through which researchers identified and ranked 12 research topics across various disciplines relating to MCH in the setting of COVID-19. Proposed research topics included vaccine development, genomics, and artificial intelligence among others. The proposed research priorities could serve as a template for a vigorous COVID-19 research agenda by the NIH and other national funding agencies in the US.
AD  - Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas, USA.
Office of the Provost, Baylor College of Medicine, Houston, Texas, USA.
College of Nursing and Public Health, Adelphi University, Garden City, NY, USA.
Department of Pediatrics, Texas Tech University Health Sciences Center, El Paso, Texas, USA.
Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USA.
AN  - 33014627
AU  - Ikedionwu, C. A.
AU  - Dongarwar, D.
AU  - Yusuf, K. K.
AU  - Maiyegun, S. O.
AU  - Ibrahimi, S.
AU  - Salihu, H. M.
C1  - 10/6/2020
C2  - PMC7520884
DB  - PubMed
DO  - 10.21106/ijma.410
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - International journal of MCH and AIDS
KW  - Artificial intelligence
Big data
Covid-19
Coronavirus
Mch
Maternal and child health
Pandemics
LA  - eng
N1  - 2161-864x
Ikedionwu, Chioma A
Dongarwar, Deepa
Yusuf, Korede K
Maiyegun, Sitratullah O
Ibrahimi, Sahra
Salihu, Hamisu M
Journal Article
Int J MCH AIDS. 2020;9(3):394-396. doi: 10.21106/ijma.410. Epub 2020 Sep 15.
PY  - 2020
SN  - 2161-8674 (Print)
2161-864x
SP  - 394-396
ST  - Using Nominal Group Technique to Elucidate a COVID-19 Research Agenda for Maternal and Child Health (MCH) Populations
T2  - International journal of MCH and AIDS
TI  - Using Nominal Group Technique to Elucidate a COVID-19 Research Agenda for Maternal and Child Health (MCH) Populations
VL  - 9
ID  - 7785384
ER  - 

TY  - JOUR
AB  - African Americans are bearing a disproportionate burden of morbidity and mortality due to COVID-19 pandemic. To our knowledge, no previous study has delineated inequities potentially incentivized by systemic racism, and whether synergistic effects impose an abnormally high burden of social determinants of mental health on African American families in the era of COVID-19 pandemic. We applied the social ecological model (SEM) to portray inequities induced by systemic racism that impact the mental health of African American families. In our model, we identified systemic racism to be the primary operator of mental health disparity, which disproportionately affects African American families at all levels of the SEM. Programs tailored towards reducing the disproportionate detrimental effects of COVID-19 on the mental health of African Americans need to be culturally appropriate and consider the nuances of systemic racism, discrimination, and other institutionalized biases.
AD  - College of Nursing and Public Health, Adelphi University, Garden City, NY, USA.
Center of Excellence in Health Equity, Training and Research, Baylor College of Medicine, Houston, Texas, USA.
Office of the Provost, Baylor College of Medicine, Houston, Texas, USA.
Department of Pediatrics, Texas Tech University Health Science Center, Paul L Foster School of Medicine, El Paso, Texas, USA.
Family and Community Medicine, Baylor College of Medicine, Houston, Texas, USA.
AN  - 33014626
AU  - Ibrahimi, S.
AU  - Yusuf, K. K.
AU  - Dongarwar, D.
AU  - Maiyegun, S. O.
AU  - Ikedionwu, C.
AU  - Salihu, H. M.
C1  - 10/6/2020
C2  - PMC7520885
DB  - PubMed
DO  - 10.21106/ijma.408
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - International journal of MCH and AIDS
KW  - African American
Covid-19
Mental health
Social determinants of mental health
Systemic racism
LA  - eng
N1  - 2161-864x
Ibrahimi, Sahra
Yusuf, Korede K
Dongarwar, Deepa
Maiyegun, Sitratullah Olawunmi
Ikedionwu, Chioma
Salihu, Hamisu M
Journal Article
Int J MCH AIDS. 2020;9(3):390-393. doi: 10.21106/ijma.408. Epub 2020 Sep 16.
PY  - 2020
SN  - 2161-8674 (Print)
2161-864x
SP  - 390-393
ST  - COVID-19 Devastation of African American Families: Impact on Mental Health and the Consequence of Systemic Racism
T2  - International journal of MCH and AIDS
TI  - COVID-19 Devastation of African American Families: Impact on Mental Health and the Consequence of Systemic Racism
VL  - 9
ID  - 7785385
ER  - 

TY  - JOUR
AD  - Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), Madrid, España.
Instituto de Investigaci�Qn Sanitaria-Hospital Universitario Fundaci�Qn Jiménez D�Taz (IIS-FJD), Madrid, España.
Centro de Investigaci�Qn Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), España.
AN  - 33012951
AU  - Ib֙ñez, B.
C1  - 10/6/2020
C2  - PMC7524679
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.recesp.2020.09.022
DP  - NLM
ET  - 2020/10/06
J2  - Revista espanola de cardiologia
LA  - spa
N1  - 1579-2242
Ib֙ñez, Borja
Journal Article
Rev Esp Cardiol. 2020 Sep 30. doi: 10.1016/j.recesp.2020.09.022.
OP  - Infartos en tiempos de la COVID-19.
PY  - 2020
SN  - 0300-8932 (Print)
0300-8932
ST  - [Myocardial infarction in times of COVID-19]
T2  - Revista espanola de cardiologia
TI  - [Myocardial infarction in times of COVID-19]
ID  - 7785527
ER  - 

TY  - JOUR
AB  - This study aims to analyze the role of cross-cultural country differences during a global pandemic. Based on country cultural dimensions and country economic indicators, the research proposes specific policies that might prove of value in order to manage and better respond to present and future critical events such as the 2020 SARS-CoV-2 outbreak. The methodology is based on multivariate analysis for the first set of countries and cross-country comparative analysis for the second set of countries. Research results reveal the critical role of the cultural dimensions individualism, power distance, masculinity, long-term orientation and indulgence, along with the country economic context in the magnitude of the consequences of a global pandemic within a country specific context. Based on these results, the study proposes policies adjusted to the countries specific cultural and economic frameworks in order to promote the most effective and efficient management of a critical event such as a global pandemic. © 2020, Springer Nature B.V.
AD  - College of Business Administration, University of Science and Technology of Fujairah, Fujairah, United Arab Emirates
College of Business Administration, Ajman University, Ajman, United Arab Emirates
AU  - Ibanez, A.
AU  - Sisodia, G. S.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s10708-020-10306-0
J2  - GeoJournal
KW  - Cross-cultural management
Cultural dimensions
Global pandemic
Policies
SARS-CoV-2
Economics
Comparative analysis
Country differences
Economic framework
Economic indicators
Efficient managements
Long-term orientation
Multi variate analysis
Multivariant analysis
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
CODEN: GEOJD
Correspondence Address: Sisodia, G.S.; College of Business Administration, Ajman UniversityUnited Arab Emirates; email: Singh_gis@yahoo.co.in
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PY  - 2020
SN  - 03432521 (ISSN)
ST  - The role of culture on 2020 SARS-CoV-2 Country deaths: a pandemic management based on cultural dimensions
T2  - GeoJournal
TI  - The role of culture on 2020 SARS-CoV-2 Country deaths: a pandemic management based on cultural dimensions
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091730491&doi=10.1007%2fs10708-020-10306-0&partnerID=40&md5=e285e330633b99c3802bf51cac02097a
ID  - 7783318
ER  - 

TY  - JOUR
AD  - Department of Internal Medicine, Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA ; Department of Internal Medicine, Cardiovascular Medicine, Yale School of Medicine, New Haven, Connecticut, USA
AN  - 2448280617
AU  - Hummel, James P.
AU  - Akar, Joseph G.
C1  - 10/6/2020
DA  - Oct 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/jce.14721
DP  - ProQuest Central
IS  - 10
KW  - Medical Sciences--Cardiovascular Diseases
COVID-19
Azithromycin
Hydroxychloroquine
LA  - English
N1  - Copyright - © 2020 Wiley Periodicals LLC
PY  - 2020
SN  - 10453873
SP  - 2795
ST  - Reply to: “QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID�?9: The need for pharmacogenetic insights�?
T2  - Journal of Cardiovascular Electrophysiology
TI  - Reply to: “QT prolongation with hydroxychloroquine and azithromycin for the treatment of COVID�?9: The need for pharmacogenetic insights�?
UR  - https://www.proquest.com/docview/2448280617?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=unknown&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Reply+to%3A+%26ldquo%3BQT+prolongation+with+hydroxychloroquine+and+azithromycin+for+the+treatment+of+COVID%E2%80%9019%3A+The+need+for+pharmacogenetic+insights%26rdquo%3B&title=Journal+of+Cardiovascular+Electrophysiology&issn=10453873&date=2020-10-01&volume=31&issue=10&spage=2795&au=Hummel%2C+James+P%3BAkar%2C+Joseph+G&isbn=&jtitle=Journal+of+Cardiovascular+Electrophysiology&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fjce.14721
VL  - 31
ID  - 7784851
ER  - 

TY  - JOUR
AB  - SARS, caused by a novel CoV, first emerged in Southern China in November 2002 before spreading to 29 countries/regions within a few weeks in 2003. Bats are natural reservoirs of SARS-like CoVs. The presence of SARS-like CoVs in horseshoe bats raised the possible role of bats in previous and future SARS outbreaks in humans. Tracheal intubation, manual ventilation before intubation, tracheotomy and noninvasive ventilation increased the risk of nosocomial SARS transmission to healthcare workers; a bed distance of 1 m apart, staff working while experiencing symptoms and high flow oxygen 6 L.minsup-1/sup increased the risk of super-spreading events. The unexpected emergence, rapid spread and high morbidity and mortality of SARS made it impossible to set up RCT of any antiviral agents and other therapies against SARS-CoV infection. Retrospective analyses of non-RCT data suggested that protease inhibitors, IFN and convalescent plasma might have some beneficial effects, whereas ribavirin led to significant haemolysis without any clinical benefit. Copyright © ERS 2016.
AD  - (Hui, Lee) Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong (Hui, Lee) Stanley Ho Center for Emerging Infectious Diseases, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
D.S. Hui, Dept of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong. E-mail: dschui@cuhk.edu.hk
AN  - 2004210273
AU  - Hui, D. S.
AU  - Lee, N.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1183/2312508X.10009915
DP  - Ovid Technologies
IS  - 9781849840705
KW  - article
China
controlled study
drug therapy
endotracheal intubation
health care personnel
hemolysis
human
manual ventilation
morbidity
mortality
nonhuman
noninvasive ventilation
retrospective study
Rhinolophus
SARS coronavirus
superspreading event
tracheostomy
convalescent plasma
oxygen
proteinase inhibitor
ribavirin
LA  - English
PY  - 2016
SN  - 2312-508X
2312-5098
SP  - 1-20
ST  - Severe acute respiratory syndrome coronavirus
T2  - ERS Monograph
TI  - Severe acute respiratory syndrome coronavirus
UR  - https://books.ersjournals.com/titles
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2004210273
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1183%2F2312508X.10009915&issn=2312-508X&isbn=&volume=2016&issue=9781849840705&spage=1&pages=1-20&date=2016&title=ERS+Monograph&atitle=Severe+acute+respiratory+syndrome+coronavirus&aulast=Hui&pid=%3Cauthor%3EHui+D.S.%2CLee+N.%3C%2Fauthor%3E&%3CAN%3E2004210273%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 2016
ID  - 7783022
ER  - 

TY  - JOUR
AD  - Specialty Trainee, Acute Intensive Care Unit, Wythenshawe Hospital, Manchester, UK.
Consultant, Department of Anaesthesia, Wythenshawe Hospital, Manchester, UK.
Consultant, Department of Cardiothoracic Anaesthesia and Intensive Care, Wythenshawe Hospital, Manchester, UK.
Senior Clinical Lecturer in Anaesthesia, Lancaster Medical School, Lancaster, UK.
AN  - 33016575
AU  - Huda, T.
AU  - Greig, D.
AU  - Strang, T.
AU  - Shelton, C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/tct.13262
DP  - NLM
ET  - 2020/10/06
J2  - The clinical teacher
LA  - eng
N1  - 1743-498x
Huda, Tuheen
Orcid: 0000-0003-0558-5717
Greig, Douglas
Strang, Timothy
Shelton, Clifford
Orcid: 0000-0002-8438-398x
Journal Article
England
Clin Teach. 2020 Oct 5. doi: 10.1111/tct.13262.
PY  - 2020
SN  - 1743-4971
ST  - Preparation for COVID-19: lessons from simulation
T2  - clinical teacher
TI  - Preparation for COVID-19: lessons from simulation
ID  - 7785193
ER  - 

TY  - JOUR
AB  - BACKGROUND: Effective contact tracing is labor- and time-intensive during the coronavirus disease 2019 (COVID-19) pandemic, but essential in the absence of effective treatment and vaccines. Singapore launched the first Bluetooth-based contact tracing app- "TraceTogether" in March 2020 to augment its contact tracing capabilities. OBJECTIVE: This study aims to compare the performance of the contact tracing app-"TraceTogether" with a wearable tag-based Real-Time Locating System and validate them against the Electronic Medical Records at the National Centre for Infectious Disease (NCID), the national referral center for COVID-19 screening. METHODS: All patients and physicians in NCID's screening center were issued with RTLS tags for contact tracing. Eighteen physicians deployed to NCID's screening center from May 10-19, 2020 activated the "TraceTogether" app on their smartphones during shifts and urged patients to whom they medically attended to use the app. We compared patient contacts identified by "TraceTogether" and tag-based RTLS within NCID's vicinity during the physicians' 10-day posting. We further validated both digital contact tracing tools by verifying the physician-patient contacts with the EMR of 156 patients who attended at NCID's screening center over a 24-hr time frame within the study period. RESULTS: RTLS had a high sensitivity of 95.3% in detecting all patient contacts identified either by the system or "TraceTogether" while "TraceTogether" had an overall sensitivity of 6.5%, performing significantly better on Android phones (Android: 9.7%, iPhone: 2.7%, P.001). When validated against the EMR, RTLS tags had a sensitivity of 96.9% and specificity of 83.1% while "TraceTogether" detected only two patient contacts with physicians who did not attend to them. CONCLUSIONS: "TraceTogether" had a much lower sensitivity than tag-based RTLS in identifying patient contacts in a clinical setting. Although tag-based RTLS performed well for contact tracing in the clinical setting, its implementation in the community would be more challenging than "TraceTogether". Given the uncertainty on the adoption and capabilities of contact tracing apps, policy makers should be cautioned against the over-reliance on such apps for contact tracing. Nonetheless, leveraging on technology to augment conventional manual contact tracing was a necessary move for life to return to some normalcy over the long haul of COVID-19.
AD  - Department of Clinical Epidemiology, Tan Tock Seng Hospital, 16 Jln Tan Tock Seng, Singapore, SG.
Department of Urology, Tan Tock Seng Hospital, Singapore, SG.
Department of Eat Nose Throat [ENT], Tan Tock Seng Hospital, Singapore, SG.
Department of Emergency Services, Tan Tock Seng Hospital, Singapore, SG.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SG.
AN  - 33006944
AU  - Huang, Z.
AU  - Guo, H.
AU  - Lee, Y. M.
AU  - Ho, E. C.
AU  - Ang, H.
AU  - Chow, A.
C1  - 10/6/2020
DA  - Sep 30
DB  - PubMed
DO  - 10.2196/23148
DP  - NLM
ET  - 2020/10/03
J2  - JMIR mHealth and uHealth
LA  - eng
N1  - 2291-5222
Huang, Zhilian
Guo, Huiling
Lee, Yee Mun
Ho, Eu Chin
Ang, Hou
Chow, Angela
Journal Article
Canada
JMIR Mhealth Uhealth. 2020 Sep 30. doi: 10.2196/23148.
PY  - 2020
SN  - 2291-5222
ST  - Performance of digital contact tracing tools for COVID-19 response in Singapore
T2  - JMIR mHealth and uHealth
TI  - Performance of digital contact tracing tools for COVID-19 response in Singapore
ID  - 7788916
ER  - 

TY  - JOUR
AB  - Aims: Coronavirus disease 2019 (COVID-19) which is a novel pneumonia can rapidly progress to acute respiratory distress syndrome, septic shock, and multiple organ dysfunction syndrome. It has appeared in 196 countries around the world. We aimed to clarify the associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes. Method(s): We performed a retrospective, single-center study of 151 patients without diabetes in Tongji Hospital from January 1, 2020 to February 28, 2020. Past medical histories, clinical features and laboratory parameters were collected in these patients. Result(s): Compared with survivors, non-survivors were more likely to have underlying medical conditions including hypertension and chronic pulmonary diseases. Non-survivors had higher C-reactive protein (CRP), procalcitonin (PCT), interleukin (IL)-2R, IL-6, IL-8 and, tumor necrosis factor-alpha (TNF-alpha) levels, while lower lymphocyte counts as compared with those of survivors (all P0.05). Besides, patients with higher fasting plasma glucose (FPG) had higher IL-6, IL-8, CRP levels and mortality; while lower lymphocyte counts. After adjusting for age and gender, each tertile increment of FPG levels conferred 3.54-fold higher risks of death (odds ratio, 3.54; 95% confidential interval, 1.25-10.06, P=0.018). Conclusion(s): Non-survivors combined with more comorbidities, more severe infection, and worse liver, kidney and cardiac function in patients without diabetes. Additionally, fasting plasma glucose levels were significantly associated with the risk of death in patients even with normal FPG and HbA1c levels. Copyright © 2020
AD  - (Huang, Guo, Zhou, Guo, Wang, Fang) Department of Endocrinology, Second Affiliated Hospital of Soochow University, Suzhou, China (Zhao) Department of Emergency Medicine, Second Affiliated Hospital of Soochow University, Suzhou, China (Li) Department of Cardiology, Second Affiliated Hospital of Soochow University, Suzhou, China (Sun) Department of General Surgery, Second Affiliated Hospital of Soochow University, Suzhou, China (Bian) Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (Fang) Department of Nutrition, Second Affiliated Hospital of Soochow University, Suzhou, China
X. Bian, Department of Endocrinology, Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou 215000, China. E-mail: nkbxn@163.com
AN  - 2007958292
AU  - Huang, Y.
AU  - Guo, H.
AU  - Zhou, Y.
AU  - Guo, J.
AU  - Wang, T.
AU  - Zhao, X.
AU  - Li, H.
AU  - Sun, Y.
AU  - Bian, X.
AU  - Fang, C.
C1  - 10/6/2020
DA  - November
DB  - Embase
DO  - http://dx.doi.org/10.1016/j.diabres.2020.108448
DP  - Ovid Technologies
IS  - 108448
KW  - covid-19
Mortality
Plasma glucose
adult
article
chronic lung disease
clinical feature
comorbidity
controlled study
coronavirus disease 2019
diabetes mellitus
female
gender
glucose blood level
heart function
human
hypertension
kidney
liver
lymphocyte count
major clinical study
male
medical history
protein expression
retrospective study
survivor
C reactive protein
endogenous compound
hemoglobin A1c
interleukin 2
interleukin 6
interleukin 8
procalcitonin
tumor necrosis factor
LA  - English
PY  - 2020
SN  - 0168-8227
1872-8227
ST  - The associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes
T2  - Diabetes Research and Clinical Practice
TI  - The associations between fasting plasma glucose levels and mortality of COVID-19 in patients without diabetes
UR  - http://www.elsevier.com/locate/diabres
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007958292
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:32946851&id=10.1016%2Fj.diabres.2020.108448&issn=0168-8227&isbn=&volume=169&issue=&spage=&pages=&date=2020&title=Diabetes+Research+and+Clinical+Practice&atitle=The+associations+between+fasting+plasma+glucose+levels+and+mortality+of+COVID-19+in+patients+without+diabetes&aulast=Huang&pid=%3Cauthor%3EHuang+Y.%2CGuo+H.%2CZhou+Y.%2CGuo+J.%2CWang+T.%2CZhao+X.%2CLi+H.%2CSun+Y.%2CBian+X.%2CFang+C.%3C%2Fauthor%3E&%3CAN%3E2007958292%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 169 (no pagination)
ID  - 7782889
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Patients with cancer are usually immunosuppressive and susceptible to COVID-19 infection. Asymptomatic COVID-19 cases are infective and cannot be identified by symptom-based screening. There is an urgent need to control virus spread by asymptomatic carriers at cancer centres. We aim to describe the characteristics, screening methods, and outcomes of cancer patients with asymptomatic COVID-19 infection and to further explore anti-tumour treatment for this population. PATIENTS AND METHODS: We reviewed patients with cancer who were admitted to Hubei Cancer Hospital in Wuhan from February 1, 2020, to April 4, 2020. We collected demographic data, laboratory findings, treatment information, nucleic acid and serum test results, chest computed tomography (CT) information and survival status of cancer patients diagnosed with asymptomatic COVID-19 infection. RESULTS: A total of 16 cancer patients with asymptomatic COVID-19 infection were confirmed. The most common cancer type was breast cancer. The blood cell counts of most patients were in the normal range. Lymphocytes of 100% of asymptomatic carriers were in the normal range. Thirteen (81.3%) patients were positive for virus-specific IgM antibodies, and three (18.8%) were positive by PCR; only one (6.3%) patient showed novel coronavirus pneumonia features on CT. Three (18.3%) patients died, and the cause of death was considered malignancy caused by delaying anti-tumour treatment. CONCLUSIONS: Our study shows that the lymphocytes of 100% of asymptomatic carriers were in the normal range. This result indicates that the host immunity of asymptomatic carriers is not significantly disrupted by COVID-19. Single PCR detection is not sufficient to screen among asymptomatic individuals, and a combination of PCR tests, serological tests and CT is of great importance. Unless the tumour is life-threatening or rapidly progressing, we advise restarting active anti-tumour therapy after PCR tests become negative.
AD  - Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. hbchgcp_003@163.com.
AN  - 33015823
AU  - Huang, Q.
AU  - Hu, S.
AU  - Ran, F. M.
AU  - Liang, T. J.
AU  - Wang, H. X.
AU  - Chen, C. C.
AU  - Zhang, J.
AU  - Ou, W. L.
AU  - Dong, S.
AU  - Cai, Q.
AU  - Luo, C. G.
AU  - Qian, Y.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23070
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Huang, Q
Hu, S
Ran, F-M
Liang, T-J
Wang, H-X
Chen, C-C
Zhang, J
Ou, W-L
Dong, S
Cai, Q
Luo, C-G
Qian, Y
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9760-9764. doi: 10.26355/eurrev_202009_23070.
PY  - 2020
SN  - 1128-3602
SP  - 9760-9764
ST  - Asymptomatic COVID-19 infection in patients with cancer at a cancer-specialized hospital in Wuhan, China - Preliminary results
T2  - European review for medical and pharmacological sciences
TI  - Asymptomatic COVID-19 infection in patients with cancer at a cancer-specialized hospital in Wuhan, China - Preliminary results
VL  - 24
ID  - 7785242
ER  - 

TY  - JOUR
AB  - Severe coronavirus disease 2019 (COVID-19) has been associated with certain preexisting health conditions and can cause respiratory failure along with other multi-organ injuries. However, the mechanism of these relationships is unclear, and prognostic biomarkers for the disease and its systemic complications are lacking. This study aims to examine the plasma protein profile of COVID-19 patients and evaluate overlapping protein modules with biomarkers of common comorbidities. Blood samples were collected from COVID-19 cases (n=307) and negative controls (n=78) among patients with acute respiratory distress. Proteins were measured by proximity extension assay utilizing next-generation sequencing technology. Its associations to COVID-19 disease characteristics were compared to that of preexisting conditions and established biomarkers for myocardial infarction (MI), stroke, hypertension, diabetes, smoking, and chronic kidney disease. Several proteins were differentially expressed in COVID-19, including multiple pro-inflammatory cytokines such as IFN-gamma, CXCL10, and CCL7/MCP-3. Elevated IL-6 was associated with increased severity, while baseline IL1RL1/ST2 levels were associated with a worse prognosis. Network analysis identified several protein modules associated with COVID-19 disease characteristics overlapping with processes of preexisting hypertension and impaired kidney function. BNP and NTpro-BNP, markers for MI and stroke, increased with disease progression and were positively associated with severity. MMP12 was similarly elevated and has been previously linked to smoking and inflammation in emphysema, along with increased cardiovascular disease risk. In conclusion, this study provides an overview of the systemic effects of COVID-19 and candidate biomarkers for clinical assessment of disease progression and the risk of systemic complications.Competing Interest StatementThe authors have declared no competing interest.Funding StatementStudy data was provide by Massachusetts General Hospitalm (MGH) in collaboration with Olink Proteomics.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:Study was approved and conducted at the Massachusetts General Hospital, and resulting data have already been made publicly available by request.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesStudy data is available for request as of October 2, 2020.https://info.olink.com/mgh-covid-study-overview-page
AU  - Huang, Jesse
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205609
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205609
ST  - Comparing biomarkers for COVID-19 disease with commonly associated preexisting conditions and complications (preprint)
T2  - medRxiv
TI  - Comparing biomarkers for COVID-19 disease with commonly associated preexisting conditions and complications (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205609.abstract
ID  - 7788891
ER  - 

TY  - JOUR
AD  - Department of Nephrology, Wuhan NO.1 Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
The second affiliated college of medicine, Guangzhou university of Chinese medicine.
WuHan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology.
The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Scienåce and Technology.
WuHan No.5 Hospital.
Wuhan Third Hospital(Tongren Hospital of Wuhan University).
Renmin Hospital of Wuhan University.
The First Affiliated Medical College, Hubei University of Traditional Chinese Medicine, Wuhan, China.
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
AN  - 33012089
AU  - Hu, Y.
AU  - Tu, C.
AU  - Dong, J. W.
AU  - Chen, W. L.
AU  - Wang, X. H.
AU  - Luo, D.
AU  - Shi, M.
AU  - Zhou, M.
AU  - Song, Y.
AU  - Zhang, C.
AU  - Xiong, F.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1111/1744-9987.13590
DP  - NLM
ET  - 2020/10/05
J2  - Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
LA  - eng
N1  - 1744-9987
Hu, Yanglin
Orcid: 0000-0002-1130-3467
Tu, Can
Dong, Jun-Wu
Chen, Wen-Li
Wang, Xiao-Hui
Luo, Dan
Shi, Ming
Zhou, Mengliang
Song, Yuting
Zhang, Chun
Xiong, Fei
Journal Article
Australia
Ther Apher Dial. 2020 Oct 3. doi: 10.1111/1744-9987.13590.
PY  - 2020
SN  - 1744-9979
ST  - Bed-sided short-duration Renal Replacement Therapy provide a possible option to treat Non-critical COVID-19 in maintenance hemodialysis (MHD) patients in public health crisis
T2  - Therapeutic apheresis and dialysis : official peer-reviewed journal of International Society for Apheresis, Japanese Society for Apheresis, Japanese Society for Dialysis Therapy
TI  - Bed-sided short-duration Renal Replacement Therapy provide a possible option to treat Non-critical COVID-19 in maintenance hemodialysis (MHD) patients in public health crisis
ID  - 7785625
ER  - 

TY  - JOUR
AB  - Background. This study was aimed to investigate the application of SARS-CoV-2 IgM and IgG antibodies in diagnosis of COVID-19 infection. Method. This study enrolled a total of 178 patients at Huangshi Central Hospital from January to February 2020. Among them, 68 patients were SARS-CoV-2 infected, confirmed with nucleic acid test (NAT) and CT imaging. Nine patients were in the suspected group (NAT negative) with fever and other respiratory symptoms. 101 patients were in the control group with other diseases and negative to SARS-CoV-2 infection. After serum samples were collected, SARS-CoV-2 IgG and IgM antibodies were tested by chemiluminescence immunoassay (CLIA) for all patients. Results. The specificity of serum IgM and IgG antibodies to SARS-CoV-2 was 99.01% (100/101) and 96.04% (97/101), respectively, and the sensitivity was 88.24% (60/68) and 97.06% (66/68), respectively. The combined detection rate of SARS-CoV-2 IgM and IgG antibodies was 98.53% (67/68). Conclusion. Combined detection of serum SARS-CoV-2 IgM and IgG antibodies had better sensitivity compared with single IgM or IgG antibody testing, which can be used as an important diagnostic tool for SARS-CoV-2 infection and a screening tool of potential SARS-CoV-2 carriers in clinics, hospitals, and accredited scientific laboratories.
AD  - Department of Clinical Laboratory, Huangshi Central Hospital, Edong Healthcare Group (Affiliated Hospital of Hubei Polytechnic University), No. 141 Tianjin Road, Huangshi City, Hubei 435000, China ; Department of Clinical Laboratory, Huangshi Central Hospital, Edong Healthcare Group (Affiliated Hospital of Hubei Polytechnic University), No. 141 Tianjin Road, Huangshi City, Hubei 435000, China
AN  - 2448259441
AU  - Hu, Fang
AU  - Shang, Xiaoling
AU  - Chen, Meizhou
AU  - Zhang, Changliang
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/1020843
DP  - ProQuest Central
KW  - Medical Sciences--Communicable Diseases
Laboratories
Infections
Nucleic acids
Acids
Antibodies
Severe acute respiratory syndrome coronavirus 2
Signs and symptoms
Genomes
COVID-19
Viral diseases
Chemiluminescence
Diagnosis
Immunoassay
Diagnostic software
Proteins
Fever
Sensitivity
Computed tomography
Severe acute respiratory syndrome
Immunoglobulin M
Immune system
Pandemics
Immunoglobulin G
Diagnostic systems
IgG antibody
Immunoglobulins
Patients
Coronaviruses
Disease transmission
China
LA  - English
N1  - Copyright - Copyright © 2020 Fang Hu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
SubjectsTermNotLitGenreText - China
PY  - 2020
SN  - 17129532
ST  - Joint Detection of Serum IgM/IgG Antibody Is an Important Key to Clinical Diagnosis of SARS-CoV-2 Infection
T2  - Canadian Journal of Infectious Diseases & Medical Microbiology
TI  - Joint Detection of Serum IgM/IgG Antibody Is an Important Key to Clinical Diagnosis of SARS-CoV-2 Infection
UR  - https://www.proquest.com/docview/2448259441?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Joint+Detection+of+Serum+IgM%2FIgG+Antibody+Is+an+Important+Key+to+Clinical+Diagnosis+of+SARS-CoV-2+Infection&title=The+Canadian+Journal+of+Infectious+Diseases+%26+Medical+Microbiology&issn=17129532&date=2020-01-01&volume=2020&issue=&spage=&au=Hu%2C+Fang%3BShang%2C+Xiaoling%3BChen%2C+Meizhou%3BZhang%2C+Changliang&isbn=&jtitle=The+Canadian+Journal+of+Infectious+Diseases+%26+Medical+Microbiology&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F1020843
VL  - 2020
ID  - 7784942
ER  - 

TY  - JOUR
AU  - Howard-Grenville, Jennifer
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Grand Challenges, Covid-19 and the Future of Organizational Scholarship
T2  - Journal of Management Studies
TI  - Grand Challenges, Covid-19 and the Future of Organizational Scholarship
UR  - https://doi.org/10.1111/joms.12647
ID  - 7788293
ER  - 

TY  - JOUR
AU  - Howard, Brittany E.
AU  - Thorwarth, Ryan M.
AU  - Karam, Karam Abi
AU  - Snider, Sam L.
AU  - Forzani, Erica
AU  - Hentz, Joseph G.
AU  - Graf, Erin H.
AU  - Patel, Bhavesh
AU  - McKay, Kelly J.
AU  - Hinni, Michael L.
AU  - Lal, Devyani
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - elastomeric respirator, elastomeric half mask respirator, reusable respirator, sterile field, COVID, SARS CoV2, SARS, respiratory protection, respiratory personal protection equipment, personal protection equipment, PPE, sterile field contamination, sur
PY  - 2020
ST  - Elastomeric Respirator Contamination of Sterile Fields Compared to Surgical Masks (preprint)
T2  - SSRN
TI  - Elastomeric Respirator Contamination of Sterile Fields Compared to Surgical Masks (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3673215
ID  - 7788899
ER  - 

TY  - GEN
AN  - NCT04576351
AU  - Hospital, Oslo University
AU  - University Hospital, Akershus
AU  - Hospital, Haukeland University
AU  - HF, Helse Stavanger
AU  - Hospital, St. Olavs
AU  - Norway, University Hospital of North
AU  - Trust, Vestre Viken Hospital
AU  - Telemark, Sykehuset
AU  - HF, Sykehuset Innlandet
AU  - Trust, Ostfold Hospital
AU  - Vestfold, The Hospital of
AU  - HF, Sorlandet Hospital
AU  - HF, Nordlandssykehuset
AU  - Trust, Møre og Romsdal Hospital
C1  - 10/6/2020
DA  - September 1
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19
N1  - No Results Available
Other: Observation
Rate of peripheral and central nervous affection|Rate of psychiatric disorders at 6-months follow-up|Rate of psychiatric disorders at 12-months follow-up|Neuropsychological function at 6-months follow up|Neuropsychological function at 12-months follow up and change in function from 6 to 12 months.|Rate of stroke at 6-months follow up|Rate of stroke at 12-months follow up|Rate of death at 6-months follow-up|Rate of death at 12-months follow-up|Rate of peripheral nervous affection assessed by clinical neurological examination and/or EMG/neurography at 6-months follow-up|Rate of peripheral nervous affection assessed by clinical neurological examination and/or EMG/neurography at 12-months follow-up|Rate of myopathy at 6-months follow-up|Rate of myopathy at 12-months follow-up|Rate of brain MRI pathology at 6-months follow-up|Rate of brain MRI pathology at 12-months follow-up|Levels of serum neurofilaments at 6-months follow-up|Levels of serum neurofilaments at 12-months follow-up|Rate of post-COVID neurological, cognitive or neuropsychiatric manifestations in the treatment arms at 6-months follow-up|Rate of post-COVID neurological, cognitive or neuropsychiatric manifestations in the treatment arms at 12-months follow-up|Duration of hospital and rehabilitation stay
All
150
Other
Observational Model: Cohort|Time Perspective: Prospective
152727
December 31, 2023
PB  - https://ClinicalTrials.gov/show/NCT04576351
PY  - 2020
ST  - NeuroCovid
T2  - ClinicalTrials
TI  - The Norwegian Study of Nervous System Manifestations and Sequelae After COVID-19
UR  - https://ClinicalTrials.gov/show/NCT04576351
ID  - 7788854
ER  - 

TY  - JOUR
AB  - Mass vaccination is a crucial public health intervention during outbreaks or pandemics for which vaccines are available. The US government has sponsored the development of medical countermeasures, including vaccines, for public health emergencies; however, federally supported programs, including the Public Health and Emergency Preparedness program and Cities Readiness Initiative, have historically emphasized antibiotic pill dispensing over mass vaccination. While mass vaccination and pill dispensing programs share similarities, they also have fundamental differences that require dedicated preparedness efforts to address. To date, only a limited number of public assessments of local mass vaccination operational capabilities have been conducted. To fill this gap, we interviewed 37 public health and preparedness officials representing 33 jurisdictions across the United States. We aimed to characterize their existing mass vaccination operational capacities and identify challenges and lessons learned in order to support the efforts of other jurisdictions to improve mass vaccination preparedness. We found that most jurisdictions were not capable of or had not planned for rapidly vaccinating their populations within a short period of time (eg, 1 to 2 weeks). Many also noted that their focus on pill dispensing was driven largely by federal funding requirements and that preparedness efforts for mass vaccination were often self-motivated. Barriers to implementing rapid mass vaccination operations included insufficient personnel qualified to administer vaccinations, increased patient load compared to pill-dispensing modalities, logistical challenges to maintaining cold chain, and operational challenges addressing high-risk populations, including children, pregnant women, and non-English-speaking populations. Considering the expected availability of a severe acute respiratory syndrome coronavirus 2 vaccine for distribution and dispensing to the public, our findings highlight critical considerations for planning possible future mass vaccination events, including during the novel coronavirus disease 2019 pandemic.
AD  - Divya Hosangadi, MSPH, and Matthew P. Shearer, MPH, are Senior Analysts; Kelsey Lane Warmbrod, MS, MPH, is an Analyst; and Jennifer Nuzzo, DrPH, SM, is a Senior Scholar; all at the Johns Hopkins Center for Health Security, Baltimore, MD. Divya Hosangadi, Matthew P. Shearer, and Kelsey Lane Warmbrod are also Research Associates, and Jennifer Nuzzo is also an Associate Professor; all in the Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. Lilly Kan, MPH, is Senior Director, Infectious Disease and Informatics; and Michelle Cantu, MPH, is Director, Infectious Disease and Immunization; both at the National Association of County and City Health Officials, Washington, DC.
AN  - 33017195
AU  - Hosangadi, D.
AU  - Shearer, M. P.
AU  - Warmbrod, K. L.
AU  - Kan, L.
AU  - Cantu, M.
AU  - Nuzzo, J.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1089/hs.2019.0146
DP  - NLM
ET  - 2020/10/06
J2  - Health security
KW  - Covid-19
Epidemic management/response
Phep
Pandemic influenza
Public health preparedness/response
Vaccines
LA  - eng
N1  - 2326-5108
Hosangadi, Divya
Shearer, Matthew P
Warmbrod, Kelsey Lane
Kan, Lilly
Cantu, Michelle
Nuzzo, Jennifer
Journal Article
United States
Health Secur. 2020 Oct 2. doi: 10.1089/hs.2019.0146.
PY  - 2020
SN  - 2326-5094
ST  - Current State of Mass Vaccination Preparedness and Operational Challenges in the United States, 2018-2019
T2  - Health security
TI  - Current State of Mass Vaccination Preparedness and Operational Challenges in the United States, 2018-2019
ID  - 7785154
ER  - 

TY  - JOUR
AU  - Horiguchi, Yusuke
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
PY  - 2020
ST  - Debt Burden On The Future Generation: For Now, Worry More About The Current Generation! (preprint)
T2  - SSRN
TI  - Debt Burden On The Future Generation: For Now, Worry More About The Current Generation! (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3686242
ID  - 7788912
ER  - 

TY  - JOUR
AB  - Quaternary ammonium compounds (QACs) are active ingredients in over 200 disinfectants currently recommended by the U S EPA for use to inactivate the SARS-CoV-2 (COVID-19) virus The amounts of these compounds used in household, workplace, and industry settings has very likely increased, and usage will continue to be elevated given the scope of the pandemic QACs have been previously detected in wastewater, surface waters, and sediments, and effects on antibiotic resistance have been explored Thus, it is important to assess potential environmental and engineering impacts of elevated QAC usage, which may include disruption of wastewater treatment unit operations, proliferation of antibiotic resistance, formation of nitrosamine disinfection byproducts, and impacts on biota in surface waters The threat caused by COVID-19 is clear, and a reasonable response is elevated use of QACs to mitigate spread of infection Exploration of potential effects, environmental fate, and technologies to minimize environmental releases of QACs, however, is warranted
AU  - Hora, Priya I.
AU  - Pati, Sarah G.
AU  - McNamara, Patrick J.
AU  - Arnold, William A.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Increased Use of Quaternary Ammonium Compounds during the SARS-CoV-2 Pandemic and Beyond: Consideration of Environmental Implications
T2  - Environmental Science & Technology Letters
TI  - Increased Use of Quaternary Ammonium Compounds during the SARS-CoV-2 Pandemic and Beyond: Consideration of Environmental Implications
UR  - https://doi.org/10.1021/acs.estlett.0c00437
ID  - 7788208
ER  - 

TY  - JOUR
AB  - The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some COVID-19 patients encounter a severe symptom of acute respiratory distress syndrome (ARDS) with high mortality. This high severity is dependent on a cytokine storm, most likely induced by the interleukin-6 (IL-6) amplifier, which is hyper-activation machinery that regulates the nuclear factor kappa B (NF-κB) pathway and stimulated by the simultaneous activation of IL-6-signal transducer and activator of transcription 3 (STAT3) and NF-κB signaling in non-immune cells including alveolar epithelial cells and endothelial cells. We hypothesize that IL-6-STAT3 signaling is a promising therapeutic target for the cytokine storm in COVID-19, because IL-6 is a major STAT3 stimulator, particularly during inflammation. We herein review the pathogenic mechanism and potential therapeutic targets of ARDS in COVID-19 patients.
AD  - Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815 Japan. GRID: grid.39158.36. ISNI: 0000 0001 2173 7691
Headquarters, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555 Japan. GRID: grid.482503.8. ISNI: 0000 0004 5900 003X
AN  - 33014208
AU  - Hojyo, S.
AU  - Uchida, M.
AU  - Tanaka, K.
AU  - Hasebe, R.
AU  - Tanaka, Y.
AU  - Murakami, M.
AU  - Hirano, T.
C1  - 10/6/2020
C2  - PMC7527296 relationships that could be construed as a potential conflict of interest.
DB  - PubMed
DO  - 10.1186/s41232-020-00146-3
DP  - NLM
ET  - 2020/10/06
J2  - Inflammation and regeneration
LA  - eng
N1  - 1880-8190
Hojyo, Shintaro
Uchida, Mona
Tanaka, Kumiko
Hasebe, Rie
Tanaka, Yuki
Murakami, Masaaki
Orcid: 0000-0001-7159-7279
Hirano, Toshio
Journal Article
Review
Inflamm Regen. 2020 Oct 1;40:37. doi: 10.1186/s41232-020-00146-3. eCollection 2020.
PY  - 2020
SN  - 1880-9693 (Print)
1880-8190
SP  - 37
ST  - How COVID-19 induces cytokine storm with high mortality
T2  - Inflammation and regeneration
TI  - How COVID-19 induces cytokine storm with high mortality
VL  - 40
ID  - 7785416
ER  - 

TY  - JOUR
AD  - Norwich Medical School, University of East Anglia, Norwich, UK. GRID: grid.8273.e. ISNI: 0000 0001 1092 7967
GKT School of Medical Education, King's College London, London, UK. GRID: grid.13097.3c. ISNI: 0000 0001 2322 6764
University of Cambridge School of Clinical Medicine, Cambridge, UK. GRID: grid.5335.0. ISNI: 0000000121885934
Faculty of Medicine, Department of Medicine, Imperial College London, London, UK. GRID: grid.7445.2. ISNI: 0000 0001 2113 8111
AN  - 33020725
AU  - Hoernke, K.
AU  - McGrath, H.
AU  - Teh, J. Q.
AU  - Salazar, O.
C1  - 10/6/2020
C2  - PMC7527243
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s40670-020-01090-0
DP  - NLM
ET  - 2020/10/07
J2  - Medical science educator
LA  - eng
N1  - Hoernke, Katarina
Orcid: 0000-0002-4825-980x
McGrath, Hari
Orcid: 0000-0002-0037-4761
Teh, Jye Quan
Orcid: 0000-0002-0286-2953
Salazar, Oliver
Orcid: 0000-0002-2475-2480
Journal Article
United States
Med Sci Educ. 2020 Sep 30:1-2. doi: 10.1007/s40670-020-01090-0.
PY  - 2020
SN  - 2156-8650 (Print)
2156-8650
SP  - 1-2
ST  - Virtual Learning Innovations for Continuing Clinical Education during COVID-19
T2  - Medical science educator
TI  - Virtual Learning Innovations for Continuing Clinical Education during COVID-19
ID  - 7784996
ER  - 

TY  - JOUR
AB  - BACKGROUND: COVID-19 infection is caused by a novel coronavirus. One of the most used strategies that can be used to control the spread of COVID-19 is the 3T (test, trace, and treatment) strategy. This study aimed to evaluate the 3T strategy to control COVID-19 infection in a COVID-19 Referral Hospital in Depok, West Java, Indonesia. METHODS: this is a cross-sectional study conducted at the University of Indonesia Hospital. The study was conducted in June 2020 with 742 participants (staff members) using secondary data from polymerase chain reaction (PCR) test results. We presented data in the descriptive form and performed bivariate analysis using the chi-square/Fischer test for categorical data. RESULTS: the PCR test results were positive in 83 (11.1%) participants, with a case-per-tracing ratio of 1:24 and 1:2 in the first and third phases of tracing, respectively. The COVID-19 case graph for the participants decreased along with the implementation of the 3T strategy. The positivity rate in the first phase of tracing was 20% and decreased to 5% in the third phase of tracing. Staff with confirmed positive test results were advised to isolate themselves (hospital or self-isolation). Hospital isolation was found to be associated with the duration of PCR test conversion (p0.001). CONCLUSION: the 3T strategy is effective for controlling the spread of COVID-19. The strategy should be implemented simultaneously with other health precautions to reduce the risk of spreading infection.
AD  - University of Indonesia; University of Indonesia Hospital. rhidayat.md@gmail.com.
AN  - 33020332
AU  - Hidayat, R.
AU  - Aini, N.
AU  - Ilmi, A. F. N.
AU  - Azzahroh, F.
AU  - Giantini, A.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - 3T strategy
Covid-19
PCR test
Universitas Indonesia Hospital
LA  - eng
N1  - Hidayat, Rakhmad
Aini, Nurul
Ilmi, Azizah Fitriana Nurul
Azzahroh, Faiza
Giantini, Astuti
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):206-213.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 206-213
ST  - Test, Trace, and Treatment Strategy to Control COVID-19 Infection Among Hospital Staff in a COVID-19 Referral Hospital in Indonesia
T2  - Acta medica Indonesiana
TI  - Test, Trace, and Treatment Strategy to Control COVID-19 Infection Among Hospital Staff in a COVID-19 Referral Hospital in Indonesia
VL  - 52
ID  - 7785036
ER  - 

TY  - JOUR
AU  - Herold, Christian J.
AU  - Delorme, Stefan
AU  - Weber, Marc-André
AU  - Reith, Wolfgang
AU  - Helmberger, Thomas
AU  - Reiser, Max
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 10
LA  - de
PY  - 2020
SP  - 891-892
ST  - COVID-19 �B (k)eine Zumutung?!
T2  - Radiologe
TI  - COVID-19 �B (k)eine Zumutung?!
TT  - [COVID-19-never waste a crisis?!]
UR  - https://dx.doi.org/10.1007/s00117-020-00750-x
VL  - 60
ID  - 7788505
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To compare excess mortality by district quintiles according to the Human Development Index (HDI) in Metropolitan Lima, the capital of Peru, and analyze the socioeconomic factors associated with excess mortality within the context of COVID-19. METHODS: Retrospective cross-sectional analysis of the mortality records from non-violent causes registered in the National Death Information System in the 50 districts of Metropolitan Lima of the first 24 weeks of the years 2019 and 2020. Descriptive analysis was performed using contingency tables and time series graphs by sex, age group, and quintile of the district of residence according to the HDI. Negative binomial regression analysis was performed to identify possible explanatory factors for excess mortality. RESULTS: An excess of 20 093 non-violent deaths and 2,979 confirmed deaths from COVID-19 were registered in Metropolitan Lima during the study period. The increase was observed primarily in men and adults aged 60 and over. Residents in the districts belonging to the fifth quintile, according to HDI, presented, in most cases, the lowest rates. Multivariate analysis revealed that a higher HDI level (p = 0.009) and a higher proportion of inhabitants living in extreme poverty (p = 0.014) decreased the excess mortality. CONCLUSION: Excess of non-violent deaths in Metropolitan Lima is higher in the quintiles with the lowest HDI, in men, and the age group from 60 to more years of age. The study of social and economic health determinants in Peru is crucial for the design of measures to be taken by the government against the COVID-19 pandemic.
AD  - Centro de Excelencia en Investigaciones Econ�Qmicas y Sociales en Salud, Vicerrectorado de Investigaci�Qn, Universidad San Ignacio de Loyola, Lima, Perú. Email: ahernandez@usil.edu.pe. Address: Universidad San Ignacio de Loyola 550 La Fontana Av., La Molina 00012 Lima, Perú. ORCID: 0000-0003-1431-2526.
Facultad de Econom�Ta y Planificaci�Qn, Universidad Nacional Agraria La Molina, Lima, Perú. ORCID:0000-0002-2437-3894.
Facultad de Ciencias de la Salud, Universidad Cient�Tfica del Sur, Lima, Perú. ORCID: 0000-0002-3310-8689.
Instituto de Investigaci�Qn, Universidad Cat�Qlica los Ángeles de Chimbote, Chimbote, Perú. ORCID: 0000-0003-1375-8788.
AN  - 33017383
AU  - Hern֙ndez-V֙squez, A.
AU  - Gamboa-Unsihuay, J. E.
AU  - Vargas-Fern֙ndez, R.
AU  - Azañedo, D.
C1  - 10/6/2020
DA  - Sep 25
DB  - PubMed
DO  - 10.5867/medwave.2020.08.8032
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Medwave
KW  - Peru
mortality
social determinants of health
Covid-19
LA  - spa
N1  - 0717-6384
Hern֙ndez-V֙squez, Akram
Gamboa-Unsihuay, Jesús Eduardo
Vargas-Fern֙ndez, Rodrigo
Azañedo, Diego
English Abstract
Journal Article
Chile
Medwave. 2020 Sep 25;20(8):e8031. doi: 10.5867/medwave.2020.08.8032.
OP  - Exceso de mortalidad en Lima Metropolitana durante la pandemia de COVID-19: comparaci�Qn a nivel distrital.
PY  - 2020
SN  - 0717-6384
SP  - e8031
ST  - [Excess mortality in Metropolitan Lima during the COVID-19 pandemic: A district level comparison]
T2  - Medwave
TI  - [Excess mortality in Metropolitan Lima during the COVID-19 pandemic: A district level comparison]
VL  - 20
ID  - 7785138
ER  - 

TY  - JOUR
AB  - We built a mathematical model for SARS-CoV-2 transmission and analyze it using both a deterministic and a stochastic approach. We used this model to project the burden of the disease in refugee camps characterized by peculiar demographic characteristics and a high level of deprivation, including lack of medical facilities and personnel, as well as limited possibility to implement containment and quarantine measures. Most of the parameters in our model were adapted from published literature but we used our own estimates of the basic reproduction number, $R_0$ as well as the lethality by age group and gender. We projected the burden in terms of number of infections, number of deaths and number of bed-days in hospitalization and intensive care, among others. We conclude that the harsh conditions of refugee camps combined with a high share of young people leads to a relatively mild scenario for the burden of the disease.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe report is part of the DFID-UNHCR-World Bank program &quot;Building the Evidence on Protracted Forced Displacement: A Multi-Stakeholder Partnership&quot;. The program is funded by UK aid from the United Kingdom&#039;s Department for International Development (DFID), it is managed by the World Bank Group (WBG) and was established in partnership with the United Nations High Commissioner for Refugees (UNHCR). The scope of the program is to expand the global knowledge on forced displacement by funding quality research and disseminating results for the use of practitioners and policy makers.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:No IRB/oversight approval requiredAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesNo data availablehttps://bit.ly/3jdtOXX
AU  - Hernandez-Suarez, Carlos M.
AU  - Verme, Paolo
AU  - Radyakin, Sergiy
AU  - Murillo-Zamora, Efren
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20204818
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20204818
ST  - COVID-19 Outbreaks in Refugee Camps. A simulation study (preprint)
T2  - medRxiv
TI  - COVID-19 Outbreaks in Refugee Camps. A simulation study (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20204818.abstract
ID  - 7788892
ER  - 

TY  - JOUR
AD  - St Elizabeth's Medical Center, Boston, MA
Steward Carney Hospital, Boston, MA
AN  - 146192804. Language: English. Entry Date: In Process. Revision Date: 20201005. Publication Type: Article. Supplement Title: 2020 Supplement. Journal Subset: Biomedical
AU  - Hegde, Shruti
AU  - Zordok, Magdi
AU  - Nikolaeva, Maria
AU  - Bhattacharya, Adhiraj
AU  - Maysky, Michael
C1  - 10/6/2020
DB  - cin20
DO  - 10.1016/j.cardfail.2020.09.209
DP  - EBSCOhost
IS  - 10
N1  - Double Blind Peer Reviewed; Peer Reviewed; USA. NLM UID: 9442138.
PY  - 2020
SN  - 1071-9164
SP  - S71-S72
ST  - Clinical Implications of Myocardial Involvement with Covid 19: A Case Control Study
T2  - Journal of Cardiac Failure
TI  - Clinical Implications of Myocardial Involvement with Covid 19: A Case Control Study
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=cin20&AN=146192804&site=ehost-live
VL  - 26
ID  - 7784599
ER  - 

TY  - JOUR
AB  - BACKGROUND: Cardiac involvement with COVID-19 is increasingly being recognised. Clinical characteristics and outcomes of patients with COVID-19 complicated by secondary Takotsubo cardiomyopathy (TC) is poorly understood. METHODS: This retrospective case series was conducted between March and April 2020 at four hospitals of Steward Health Care Network of Massachusetts, USA. Seven patients out of 169 who had echocardiogram were identified to have features of TC. Demographic, clinical, laboratory, management and outcome were gathered from their electronic medical records. We also reviewed all the published cases of COVID-19 and TC in the literature to recognise their common clinical characteristics, risk factors and outcomes. RESULTS: In our series of seven patients, three typical, two inverted, one biventricular and one global TC were recognised. Three were females and four were males. The mean age was 71�u11 years. In-hospital death was observed in 57% of patients. Patients who belonged to the high-risk group and had high-risk echocardiographic features in our series had a 100% mortality rate. CONCLUSIONS: COVID-19 complicated by TC has a high mortality rate. Early identification of patients with COVID-19 who are at higher risk for developing secondary TC is important for the prevention of complications, and thus improved outcomes.
AD  - Cardiology, Caritas Saint Elizabeth's Medical Center, Brighton, Massachusetts, USA shruti.hegde1587@gmail.com.
Cardiology, Caritas Saint Elizabeth's Medical Center, Brighton, Massachusetts, USA.
Internal Medicine, Caritas Carney Hospital, Dorchester, Massachusetts, USA.
AN  - 33020258
AU  - Hegde, S.
AU  - Khan, R.
AU  - Zordok, M.
AU  - Maysky, M.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1136/openhrt-2020-001360
DP  - NLM
ET  - 2020/10/07
IS  - 2
J2  - Open heart
KW  - echocardiography
heart failure treatment
left ventricular assist device
stress
LA  - eng
N1  - Hegde, Shruti
Orcid: 0000-0003-0961-4722
Khan, Rizwan
Zordok, Magdi
Maysky, Michael
Journal Article
England
Open Heart. 2020 Oct;7(2):e001360. doi: 10.1136/openhrt-2020-001360.
PY  - 2020
SN  - 2053-3624 (Print)
2053-3624
ST  - Characteristics and outcome of patients with COVID-19 complicated by Takotsubo cardiomyopathy: case series with literature review
T2  - Open heart
TI  - Characteristics and outcome of patients with COVID-19 complicated by Takotsubo cardiomyopathy: case series with literature review
VL  - 7
ID  - 7785041
ER  - 

TY  - JOUR
AB  - How is it possible to account for the continuing presence of monarchy in advanced social democracies? Much traditional political science assumes teleologically that monarchies inevitably transform into republics as a higher form of governance This comparative study of the eight main European monarchies maintains otherwise: monarchy is perfectly compatible with democracy, and can help strengthen citizens? loyalty to the system of government Provided it delivers a politically impartial head of state, monarchy can endure indefinitely with government and popular support In practice, the countries studied are de facto republics, but with hereditary heads of state who occupy social roles beyond the reach of quotidian politics Monarchy?s principal danger is not republicanism, but the pressures of conflicting expectations about what is required of royal families, and the relentless intrusions of modern media in an age when royalty and celebrity are in danger of being conflated Responses to Covid-19 show how monarchs can speak to and for their nations in ways no partisan politician can
AU  - Hazell, Robert
AU  - Morris, Bob
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - European Monarchies: Guardians of Democracy?
T2  - Political Quarterly
TI  - European Monarchies: Guardians of Democracy?
UR  - https://doi.org/10.1111/1467-923X.12866
ID  - 7788260
ER  - 

TY  - JOUR
AB  - In response to the COVID-19 pandemic, the Indian government, led by Narendra Modi, imposed a stringent lockdown with only four hours notice. It paid no attention to the millions of migrants who work on a temporary basis in Indian cities. Most lost their livelihoods as a result of the lockdown, and millions sought to return to their native villages. At the same time, the rural economy confronted its own difficulties caused by the lockdown. The relief that the Modi government offered to the large numbers of poor people who had been adversely affected by its response to COVID-19 was limited and poorly delivered. The episode showed the lack of responsiveness of Indian democracy to the needs of working people and the failures of development. Yet Modi's particular brand of authoritarian populism worked so well that a government displaying very little compassion retained strong popular support.
AD  - John Harriss ( jharriss@sfu.ca ) is Professor Emeritus of International Studies at Simon Fraser University ; John Harriss ( jharriss@sfu.ca ) is Professor Emeritus of International Studies at Simon Fraser University
AN  - 2448351996
AU  - Harriss, John
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1017/S0021911820002314
DP  - ProQuest Central
IS  - 3
KW  - Literature
Authoritarian populism
circular migration
citizenship
democracy
informal economy
Narendra Modi
Migrants
Responsiveness
Muslims
COVID-19
Relief
Populism
Low income groups
Pandemics
Sympathy
Coronaviruses
Numerals
Villages
Popular support
India
LA  - English
N1  - Name - Tablighi Jamaat
Copyright - Copyright © The Association for Asian Studies, Inc., 2020
SubjectsTermNotLitGenreText - India
PY  - 2020
SN  - 00219118
SP  - 609-620
ST  - “Responding to an Epidemic Requires a Compassionate State�? How Has the Indian State Been Doing in the Time of COVID-19?
T2  - Journal of Asian Studies
TI  - “Responding to an Epidemic Requires a Compassionate State�? How Has the Indian State Been Doing in the Time of COVID-19?
UR  - https://www.proquest.com/docview/2448351996?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=%26ldquo%3BResponding+to+an+Epidemic+Requires+a+Compassionate+State%26rdquo%3B%3A+How+Has+the+Indian+State+Been+Doing+in+the+Time+of+COVID-19%3F&title=The+Journal+of+Asian+Studies&issn=00219118&date=2020-08-01&volume=79&issue=3&spage=609&au=Harriss%2C+John&isbn=&jtitle=The+Journal+of+Asian+Studies&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1017%2FS0021911820002314
VL  - 79
ID  - 7784922
ER  - 

TY  - JOUR
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University, Jazan, Saudi Arabia. wahidbiochem@gmail.com.
AN  - 33015764
AU  - Haque, S.
AU  - Jawed, A.
AU  - Akhter, N.
AU  - Dar, S. A.
AU  - Khan, F.
AU  - Mandal, R. K.
AU  - Areeshi, M. Y.
AU  - Lohani, M.
AU  - Wahid, M.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23005
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Haque, S
Jawed, A
Akhter, N
Dar, S A
Khan, F
Mandal, R K
Areeshi, M Y
Lohani, M
Wahid, M
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9244-9245. doi: 10.26355/eurrev_202009_23005.
PY  - 2020
SN  - 1128-3602
SP  - 9244-9245
ST  - Acetylsalicylic acid (Aspirin): a potent medicine for preventing COVID-19 deaths caused by thrombosis and pulmonary embolism
T2  - European review for medical and pharmacological sciences
TI  - Acetylsalicylic acid (Aspirin): a potent medicine for preventing COVID-19 deaths caused by thrombosis and pulmonary embolism
VL  - 24
ID  - 7785251
ER  - 

TY  - JOUR
AB  - The outbreak of Corona Virus Disease 2019 (COVID-19) in Wuhan has significantly impacted the economy and society globally. Countries are in a strict state of prevention and control of this pandemic. In this study, the development trend analysis of the cumulative confirmed cases, cumulative deaths, and cumulative cured cases was conducted based on data from Wuhan, Hubei Province, China from January 23, 2020 to April 6, 2020 using an Elman neural network, long short-term memory (LSTM), and support vector machine (SVM). A SVM with fuzzy granulation was used to predict the growth range of confirmed new cases, new deaths, and new cured cases. The experimental results showed that the Elman neural network and SVM used in this study can predict the development trend of cumulative confirmed cases, deaths, and cured cases, whereas LSTM is more suitable for the prediction of the cumulative confirmed cases. The SVM with fuzzy granulation can successfully predict the growth range of confirmed new cases and new cured cases, although the average predicted values are slightly large. Currently, the United States is the epicenter of the COVID-19 pandemic. We also used data modeling from the United States to further verify the validity of the proposed models.
AD  - School of Information and Communication Engineering, North University of China, Taiyuan, China.
Department of Mathematics, School of Science, North University of China, Taiyuan, China.
AN  - 33017421
AU  - Hao, Y.
AU  - Xu, T.
AU  - Hu, H.
AU  - Wang, P.
AU  - Bai, Y.
C1  - 10/6/2020
DB  - PubMed
DO  - 10.1371/journal.pone.0239960
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - PloS one
LA  - eng
N1  - 1932-6203
Hao, Yan
Xu, Ting
Hu, Hongping
Wang, Peng
Bai, Yanping
Orcid: 0000-0002-2043-8363
Journal Article
United States
PLoS One. 2020 Oct 5;15(10):e0239960. doi: 10.1371/journal.pone.0239960. eCollection 2020.
PY  - 2020
SN  - 1932-6203
SP  - e0239960
ST  - Prediction and analysis of Corona Virus Disease 2019
T2  - PloS one
TI  - Prediction and analysis of Corona Virus Disease 2019
VL  - 15
ID  - 7785136
ER  - 

TY  - JOUR
AB  - In the absence of a vaccine and medical treatments, social distancing remains the only option available to governments in order to slow the spread of global pandemics such as COVID-19 and save millions of lives. Despite the scientific evidence on the effectiveness of social distancing measures, they are not being practiced uniformly across the U.S. Accordingly, the role of compact development on the level of adherence to social distancing measures has not been empirically studied. This longitudinal study employs a natural experimental research design to investigative the impacts of compact development on reduction in travel to three types of destinations representing a range of essential and non-essential trips in 771 metropolitan counties in the U.S during the shelter-in-place order amid the COVID-19 pandemic. We employed Multilevel Linear Modeling (MLM) for the three longitudinal analyses in this study to model determinants of reduction in daily trips to grocery stores, parks, and transit stations; using travel data from Google and accounting for the hierarchical (two-level) structure of the data. We found that the challenges of practicing social distancing in compact areas are not related to minimizing essential trips. Quite the opposite, residents of compact areas have significantly higher reduction in trips to essential destinations such as grocery stores/pharmacies, and transit stations. However, residents of compact counties have significantly lower reduction in their trips to parks possibly due to the smaller homes, lack of private yards, and the higher level of anxiety amid the pandemic. This study offers a number of practical implications and directions for future research.
AD  - Department of Environmental Health and Engineering, Bloomberg School of Public Health, Johns Hopkins University, 615 N. Wolfe Street, Baltimore, MD 21205, USA.
Department of Urban & Regional Planning, San Jose State University, Washington Square, San Jose, CA 95192, USA.
AN  - 33020675
AU  - Hamidi, S.
AU  - Zandiatashbar, A.
C1  - 10/6/2020
C2  - PMC7526615
DA  - Jan
DB  - PubMed
DO  - 10.1016/j.landurbplan.2020.103952
DP  - NLM
ET  - 2020/10/07
J2  - Landscape and urban planning
KW  - COVID-19 pandemic
Compact development
Shelter-in-place
Social distancing
Urban sprawl
LA  - eng
N1  - Hamidi, Shima
Zandiatashbar, Ahoura
Journal Article
Netherlands
Landsc Urban Plan. 2021 Jan;205:103952. doi: 10.1016/j.landurbplan.2020.103952. Epub 2020 Sep 30.
PY  - 2021
SN  - 0169-2046 (Print)
0169-2046
SP  - 103952
ST  - Compact development and adherence to stay-at-home order during the COVID-19 pandemic: A longitudinal investigation in the United States
T2  - Landscape and urban planning
TI  - Compact development and adherence to stay-at-home order during the COVID-19 pandemic: A longitudinal investigation in the United States
VL  - 205
ID  - 7785015
ER  - 

TY  - JOUR
AB  - We are living in uncertain times and facing a paradigm shift in human health and sustainability. The number of SARS-CoV-2 victims is rising daily and all nations are going through dramatic effects and exploring various solutions to this imminent calamity facing the humanity. The world is confronting a public health issue that has forced it to come to a halt and evaluate the future of our modern society and our way of living. It can be stated that the sustainability of our societies inextricably depends on the performance of our global trade and supply chains. This review article is the first published assessment on the global trade and especially packaging's role in the transmittance of SARS-CoV-2 virus. Surprisingly, based on our findings, the lack of knowledge on transmittance and survival of SARS-CoV-2 in supply chain and packaging is substantial. Although there are several existing and available technologies that can be used for the risk mitigation, our assessment shows a major and timely need for broad conceptual advancements and necessary understanding of the supply chain risks associated with the viral surface transmittances. The specificity to the current and possibly future pandemics demands an increasing amount of multidisciplinary research and involvement of public and private sectors. This proposed erudition is imminent and may be highly critical in safeguarding and the sustainability of the critical supply chains in our society now and in the future.
AD  - Department of Forest Biomaterials, North Carolina State University, Raleigh, NC USA. GRID: grid.40803.3f. ISNI: 0000 0001 2173 6074
Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, NC USA. GRID: grid.40803.3f. ISNI: 0000 0001 2173 6074
AN  - 33015545
AU  - Hakovirta, M.
AU  - Hakovirta, J.
C1  - 10/6/2020
C2  - PMC7523487
DA  - Sep 29
DB  - PubMed
DO  - 10.1007/s41783-020-00101-0
DP  - NLM
ET  - 2020/10/06
J2  - Journal of packaging technology and research
KW  - Health
Packaging
Risk management
SARS-CoV-2
Supply chain
Survival
Transmittance
LA  - eng
N1  - 2520-1042
Hakovirta, Marko
Orcid: 0000-0002-4398-1529
Hakovirta, Janetta
Journal Article
Review
J Packag Technol Res. 2020 Sep 29:1-5. doi: 10.1007/s41783-020-00101-0.
PY  - 2020
SN  - 2520-1034 (Print)
2520-1034
SP  - 1-5
ST  - Transmittance and Survival of SARS-CoV-2 in Global Trade: The Role of Supply Chain and Packaging
T2  - Journal of packaging technology and research
TI  - Transmittance and Survival of SARS-CoV-2 in Global Trade: The Role of Supply Chain and Packaging
ID  - 7785296
ER  - 

TY  - JOUR
AB  - Objectives. To evaluate the role of short-term low-dose glucocorticoids in mild COVID-19 patients. Methods. We conducted a retrospective, cross-sectional, single-center study in Kunming, China. A total of 33 mild COVID-19 cases were divided into two treatment groups (with and without glucocorticoids, methylprednisolone, were used in this setting), and the absolute value of peripheral blood lymphocyte count; CD3+, CD4+, and CD8+ T cell counts; and the time to achieve negative transformation of a nucleic acid pharyngeal swab were recorded. Peripheral blood lymphocyte and T cell counts were compared between the treatment group and 25 healthy individuals. At the point of time when there was a 50% accumulation conversion rate (positive to negative nucleic acid on pharyngeal swab), and the nucleic acid turned negative in half of the patients in two groups, the peripheral blood lymphocyte and T cell counts were compared between treatment groups. Results. The mean cumulative time for the 50% negative conversion rate of the nucleic acid in the pharyngeal swab was 17.7�u5.1 days and 13.9�u5.4 days in the glucocorticoid group and the nonglucocorticoid group, respectively. The absolute peripheral blood lymphocyte count and the T cell subset count in the glucocorticoid group were lower than those in the nonglucocorticoid group. When the nucleic acid turned negative in half of the patients, the absolute value of peripheral blood lymphocyte count and CD4+ T cells of the glucocorticoid group and the nonglucocorticoid group was not significantly different; the CD3+ and CD8+ T cells in the glucocorticoid group were lower than those in the nonglucocorticoid group. The absolute peripheral blood lymphocyte count, CD3+ T cells, and CD4+ T cells in the glucocorticoid group were lower than those of the healthy group during the whole disease period, and CD8+ T cells returned to normal at 19-21 days of the disease period. There was no significant difference between the nonglucocorticoid group and the healthy group for absolute peripheral blood lymphocyte and CD8+ T cells; moreover, CD3+ T cells and CD4+ T cells were lower in the nonglucocorticoid group than those in the healthy group from the day of admission to the 18th day and returned to normal at the period of 19-21 days. The absolute peripheral lymphocyte count (P=0.048, effect size d=0.727) and T cell subset count (CD3: P=0.042, effect size d=0.655; CD4: P0.01, effect size d=0.599; and CD8: P=0.034, effect size d=0.550) in the nonglucocorticoid group were higher than those in the glucocorticoid group, and the difference between the groups was statistically significant. Conclusions. This study found that the use of short-term, low-dose glucocorticoids does not negatively influence the clinical outcome, without affecting the final clearance of viral nucleic acid in mild COVID-19 patients.
AD  - Department of Palliative Care, The Sixth Affiliated Hospital of Dali University, The Third People’s Hospital of Kunming, China ; Department of Clinical Laboratory, The Sixth Affiliated Hospital of Dali University, The Third People’s Hospital of Kunming, China ; Department of Radiology, The Sixth Affiliated Hospital of Dali University, The Third People’s Hospital of Kunming, China ; Department of Palliative Care, The Sixth Affiliated Hospital of Dali University, The Third People’s Hospital of Kunming, China
AN  - 2448265393
AU  - Hai-Yan, Fu
AU  - Luo, Yu
AU  - Jian-Peng, Gao
AU  - Wang, Lin
AU  - Hong-Juan, Li
AU  - Li, Xiang
AU  - Xue, Lian
AU  - Xiao-Qing, Tang
AU  - Hai-wen, Li
AU  - Ying-Rong, Du
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Agricultural & Environmental Science Collection; Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/2854186
DP  - ProQuest Central
KW  - Medical Sciences
Comorbidity
Blood
Nucleic acids
Acids
Glucocorticoids
Epidemiology
Lymphocytes T
Hospitals
Fever
COVID-19
Health services
Viral diseases
Statistical analysis
CD4 antigen
CD3 antigen
Drug dosages
Lymphocytes
Medical diagnosis
Patients
Conversion
Pharynx
Hypertension
Cell number
Body temperature
Peripheral blood
Coronaviruses
CD8 antigen
Methylprednisolone
China
LA  - English
N1  - Copyright - Copyright © 2020 Hai-Yan Fu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
SubjectsTermNotLitGenreText - China
PY  - 2020
SN  - 23146133
ST  - Effects of Short-Term Low-Dose Glucocorticoids for Patients with Mild COVID-19
T2  - BioMed Research International
TI  - Effects of Short-Term Low-Dose Glucocorticoids for Patients with Mild COVID-19
UR  - https://www.proquest.com/docview/2448265393?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Effects+of+Short-Term+Low-Dose+Glucocorticoids+for+Patients+with+Mild+COVID-19&title=BioMed+Research+International&issn=23146133&date=2020-01-01&volume=2020&issue=&spage=&au=Hai-Yan%2C+Fu%3BLuo%2C+Yu%3BJian-Peng%2C+Gao%3BWang%2C+Lin%3BHong-Juan%2C+Li%3BLi%2C+Xiang%3BXue%2C+Lian%3BXiao-Qing%2C+Tang%3BHai-wen%2C+Li%3BYing-Rong+Du&isbn=&jtitle=BioMed+Research+International&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F2854186
VL  - 2020
ID  - 7784932
ER  - 

TY  - JOUR
AB  - Effective treatment or vaccine is not yet available for combating SARS coronavirus 2 (SARSCoV-2) that caused the COVID-19 pandemic. Recent studies showed that two drugs, Camostat and Nafamostat, might be repurposed to treat COVID-19 by inhibiting human TMPRSS2 required for proteolytic activation of viral spike (S) glycoprotein. However, their molecular mechanisms of pharmacological action remain unclear. Here, we perform molecular dynamics simulations to investigate their native binding sites on TMPRSS2. We revealed that both drugs could spontaneously and stably bind to the TMPRSS2 catalytic center, and thereby inhibit its proteolytic processing of the S protein. Also, we found that Nafamostat is more specific than Camostat for binding to the catalytic center, consistent with reported observation that Nafamostat blocks the SARS-CoV-2 infection at a lower concentration. Thus, this study provides mechanistic insights into the Camostat and Nafamostat inhibition of the SARS-CoV-2 infection, and offers useful information for COVID-19 drug development.
AU  - Haixia, Zhu
AU  - Wenhao, Du
AU  - Menghua, Song
AU  - Qing, Liu
AU  - Andreas, Herrmann
AU  - Qiang, Huang
C1  - 10/6/2020
DB  - chemRxiv
DO  - 10.26434/chemrxiv.13049663.v1
DP  - chemRxiv
KW  - COVID-19
SARS-CoV-2
TMPRSS2
Drug action
Spontaneous binding simulation
PY  - 2020
ST  - Spontaneous Binding of Potential COVID-19 Drugs to Human Serine Protease TMPRSS2 (preprint)
T2  - chemRxiv
TI  - Spontaneous Binding of Potential COVID-19 Drugs to Human Serine Protease TMPRSS2 (preprint)
UR  - https://chemrxiv.org/articles/preprint/Spontaneous_Binding_of_Potential_COVID-19_Drugs_to_Human_Serine_Protease_TMPRSS2/13049663
ID  - 7788894
ER  - 

TY  - JOUR
AU  - H. R, Ganesha
AU  - Aithal, P. S.
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Indian Retail
Brick-and-Mortar Retail
Margin of Safety
Bandh
Lockdown
Shutdown
Market Disruption
Pandemic
COVID-19
Immunity to Market Disruptions
PY  - 2020
ST  - Extending the Margin of Safety Concept to Brick-and-Mortar Retailing in India (MoSR-b) (preprint)
T2  - SSRN
TI  - Extending the Margin of Safety Concept to Brick-and-Mortar Retailing in India (MoSR-b) (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3694376
ID  - 7788901
ER  - 

TY  - JOUR
AD  - Instituto de Medicina Tropical “Pedro Kour�T�? IPK, La Habana, Cuba
AU  - Guzm֙n, M. G.
AU  - Resik, S.
AU  - Kour�T, V.
C1  - 10/6/2020
C7  - e615
DB  - Scopus
IS  - 2
J2  - Rev. Cuba. Med. Trop.
LA  - Spanish
M3  - Note
N1  - Export Date: 6 October 2020
CODEN: RCMTB
References: D�Taz-Canel Bermúdez, Miguel M., Presidente de la República de Cuba, en la Cumbre Virtual del Movimiento de Pa�Tses No alineados Unidos contra la COVID-19, , Intervenci�Qn del jefe de la delegaci�Qn cubana, 4 de mayo de 2020; Intervenci�Qn de Miguel, M., D�Taz-Canel Bermúdez, Presidente de la República de Cuba, en la conferencia virtual de alto nivel: Econom�Ta pospandemia del ALBA-TCP, , 10 de junio de 2020, “Año 62 de la Revoluci�Qn; Miguel M., Miguel M., D�Taz-Canel Bermúdez, Presidente de la República de Cuba, en la Cumbre Mundial Virtual de la Organizaci�Qn Mundial del Trabajo, , Palabras pronunciadas por 8 de julio de 2020; Intervenci�Qn de Miguel, M., D�Taz-Canel Bermúdez, Presidente de la República de Cuba, en la videoconferencia Encuentro de L�Tderes a 30 años de creado el Foro de Sao Paulo, , 28 de julio de 2020, “Año 62 de la Revoluci�Qn; Intervenci�Qn del Ministro de Relaciones Exteriores de Cuba, Bruno Rodr�Tguez Parrilla, en la Reuni�Qn Ministerial Virtual de la CELAC sobre Asuntos de Salud para la Contenci�Qn y Seguimiento del COVID-19, , 26 de marzo de 2020; Intervenci�Qn del Ministro de Relaciones Exteriores de Cuba, Bruno Rodr�Tguez Parrilla, en el XX Consejo Pol�Ttico y el X Consejo Econ�Qmico del ALBA TCP, , 29 de junio de 2020; Discurso del Ministro de Relaciones Exteriores de la República de Cuba, Bruno Rodr�Tguez Parrilla, en la videoconferencia Primera Reuni�Qn Extraordinaria de Ministros de Asuntos Exteriores y Salud de la Asociaci�Qn de Estados del Caribe sobre COVID-19; Intervenci�Qn del Viceministro de relaciones Exteriores de Cuba, Rogelio Sierra D�Taz en la videoconferencia especial entre los Cancilleres de China y de América Latina y el Caribe en atenci�Qn a la pandemia por COVID-19, , 22 de julio de 2020; Coutin, G, Bacallao-Gallestey, J, Castellanos, L., Cuba´s Pedro Kouri Tropical medicine Institute: Battling COVID-19 one study, one test, one patient at a time (2020) MEDICC Review, 22 (2), pp. 40-44; Perez Riverol, A., the Cuban strategy for combatting the COVID-19 Pandemic (2020) MEDICC Review, 22 (3), pp. 64-68; Gorry, C., Global Collaboration in times of COVID-19: Cuba´s emergency medical contingent (2020) MEDICC Review, 22 (2), pp. 64-66
PY  - 2020
SN  - 03750760 (ISSN)
SP  - 1-4
ST  - Apuntes sobre la experiencia cubana en el enfrentamiento a la COVID-19
T2  - Revista Cubana de Medicina Tropical
TI  - Apuntes sobre la experiencia cubana en el enfrentamiento a la COVID-19
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091714368&partnerID=40&md5=b50ac935c34ecaebbbcaa103d17152dd
VL  - 72
ID  - 7783280
ER  - 

TY  - JOUR
AD  - Instituto de Medicina Tropical “Pedro Kour�T�? IPK., La Habana, Cuba
AU  - Guzm֙n, M. G.
C1  - 10/6/2020
C7  - e614
DB  - Scopus
IS  - 2
J2  - Rev. Cuba. Med. Trop.
LA  - Spanish
M3  - Editorial
N1  - Export Date: 6 October 2020
CODEN: RCMTB
Correspondence Address: Guzm֙n, M.G.; Instituto de Medicina Tropical “Pedro Kour�T�? IPK.Cuba
PY  - 2020
SN  - 03750760 (ISSN)
SP  - 1-5
ST  - El instituto de medicina tropical �tpedro kour�T�t, ipk, en el enfrentamiento a la covid-19
T2  - Revista Cubana de Medicina Tropical
TI  - El instituto de medicina tropical �tpedro kour�T�t, ipk, en el enfrentamiento a la covid-19
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091715629&partnerID=40&md5=7e15a417c4c5c08b8c4986c473881659
VL  - 72
ID  - 7783287
ER  - 

TY  - JOUR
AB  - BACKGROUND: Psychosocial responses to infectious disease outbreaks have the potential to inflict acute and longstanding mental health consequences. Early research across the globe has found wide ranging psychological responses to the current COVID-19 pandemic. Understanding how different coping styles can be effective in mitigating mental ill health would enable better tailored psychological support. AIMS: The aim of this study was to gain an understanding of psychosocial responses to the COVID-19 pandemic, including depression, anxiety and distress, as well as effective coping styles in an Australian sample. METHOD: A sample of 1,495 adults, residing in Australia between April 3rd and May 3rd 2020, completed an online survey which measured psychological distress (Impact of Events Scale-Revised), depression, anxiety, stress (DASS-21), as well as coping strategies (Brief COPE). RESULTS: 47% of the respondents were experiencing some degree of psychological distress. Females experienced higher levels of depression, anxiety and stress than males. Coping strategies associated with better mental health were positive reframing, acceptance and humour. Conversely, self-blame, venting, behavioural disengagement and self-distraction were associated with poorer mental health. CONCLUSION: Rates of psychological symptoms amongst the Australian population are similar to those reported in other countries. Findings add to the growing literature demonstrating a gender disparity in the mental health impacts of COVID-19. Positive emotion focused coping strategies may be effective for reducing psychological symptoms. Understanding psychosocial responses including beneficial coping strategies are crucial to manage the current COVID-19 situation optimally, as well as to develop mental health response plans for future pandemics.
AD  - Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Melbourne, Victoria, Australia.
Department of Rural Health, Monash University, Melbourne, Victoria, Australia.
AN  - 33016171
AU  - Gurvich, C.
AU  - Thomas, N.
AU  - Thomas, E. H.
AU  - Hudaib, A. R.
AU  - Sood, L.
AU  - Fabiatos, K.
AU  - Sutton, K.
AU  - Isaacs, A.
AU  - Arunogiri, S.
AU  - Sharp, G.
AU  - Kulkarni, J.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/0020764020961790
DP  - NLM
ET  - 2020/10/06
J2  - The International journal of social psychiatry
KW  - Covid-19
anxiety
coping
depression
mental health
LA  - eng
N1  - 1741-2854
Gurvich, Caroline
Orcid: 0000-0002-5663-3419
Thomas, Natalie
Thomas, Elizabeth Hx
Hudaib, Abdul-Rahman
Sood, Lomash
Fabiatos, Kali
Sutton, Keith
Isaacs, Anton
Arunogiri, Shalini
Sharp, Gemma
Kulkarni, Jayashri
Journal Article
England
Int J Soc Psychiatry. 2020 Oct 4:20764020961790. doi: 10.1177/0020764020961790.
PY  - 2020
SN  - 0020-7640
SP  - 20764020961790
ST  - Coping styles and mental health in response to societal changes during the COVID-19 pandemic
T2  - International journal of social psychiatry
TI  - Coping styles and mental health in response to societal changes during the COVID-19 pandemic
ID  - 7785215
ER  - 

TY  - JOUR
AB  - We describe a multifactorial investigation of a SARS-CoV-2 outbreak in a large meat processing complex in Germany. Infection event timing, spatial, climate and ventilation conditions in the processing plant, sharing of living quarters and transport, and viral genome sequences were analyzed. Our results suggest that a single index case transmitted SARS-CoV-2 to co-workers over distances of more than 8 meters, within a confined work area in which air is constantly recirculated and cooled. Viral genome sequencing shows that all cases share a set of mutations representing a novel sub-branch in the SARS-CoV-2 C20 clade. We identified the same set of mutations in samples collected in the time period between this initial infection cluster and a subsequent outbreak within the same factory, with the largest number of confirmed SARS-CoV-2 cases in a German meat processing facility reported so far. Our results indicate climate conditions, fresh air exchange rates, and airflow as factors that can promote efficient spread of SARS-CoV-2 via long distances and provide insights into possible requirements for pandemic mitigation strategies in industrial workplace settings.
AD  - Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
Institute for Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Health Office, Osnabrück, Germany.
Institute of Hygiene and Public Health, University of Bonn, Bonn, Germany.
Omikron Systems GmbH, Braunschweig, Germany.
Viral Immune Modulation Research Group, Helmholtz Centre for Infection Research, Braunschweig, Germany.
Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany.
AN  - 33012091
AU  - Günther, T.
AU  - Czech-Sioli, M.
AU  - Indenbirken, D.
AU  - Robitaille, A.
AU  - Tenhaken, P.
AU  - Exner, M.
AU  - Ottinger, M.
AU  - Fischer, N.
AU  - Grundhoff, A.
AU  - Brinkmann, M. M.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.15252/emmm.202013296
DP  - NLM
ET  - 2020/10/05
J2  - EMBO molecular medicine
KW  - Aerosol transmission
SARS-CoV-2 super spreading event
meat processing plant outbreak
viral genome sequencing
LA  - eng
N1  - 1757-4684
Günther, Thomas
Czech-Sioli, Manja
Indenbirken, Daniela
Robitaille, Alexis
Tenhaken, Peter
Exner, Martin
Ottinger, Matthias
Fischer, Nicole
Grundhoff, Adam
Brinkmann, Melanie M
Journal Article
England
EMBO Mol Med. 2020 Oct 4:e202013296. doi: 10.15252/emmm.202013296.
PY  - 2020
SN  - 1757-4676
SP  - e202013296
ST  - SARS-CoV-2 outbreak investigation in a German meat processing plant
T2  - EMBO molecular medicine
TI  - SARS-CoV-2 outbreak investigation in a German meat processing plant
ID  - 7785624
ER  - 

TY  - JOUR
AB  - For a decade, Feeding America&#039;s Map the Meal Gap (MMG) has provided sub-state-level estimates of food insecurity for both the full-population and for children Along with being extensively used by food banks, it is widely used by state- and local-governments to help plan responses to food insecurity in their communities In this paper, we describe the methods underpinning MMG, detail the approach Feeding America has used to make projections about the geography of food insecurity in 2020, and how food insecurity rates may have changed due to COVID-19 since 2018 We project an increase of 17 million Americans who are food insecure in 2020 but this aggregate increase masks substantial geographic variation found in MMG
AU  - Gundersen, Craig
AU  - Hake, Monica
AU  - Dewey, Adam
AU  - Engelhard, Emily
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Food Insecurity during COVID-19
T2  - Applied Economic Perspectives and Policy
TI  - Food Insecurity during COVID-19
UR  - https://doi.org/10.1002/aepp.13100
ID  - 7788127
ER  - 

TY  - JOUR
AU  - Guillén-Astete, Carlos
AU  - Penedo-Alonso, Roberto
AU  - Gallego-Rodr�Tguez, Paloma
AU  - Carballo-Cardona, César
AU  - Estévez-Rueda, Mar�Ta Jesús
AU  - Galli-Cambiaso, Enrique
AU  - Collado-Mart�Tn, Ana Sof�Ta
AU  - Clemente-Bermúdez, Luc�Ta
AU  - S֙nchez-G�Qmez, Carolina
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 5
LA  - es
PY  - 2020
SP  - 369-371
ST  - Niveles de ansiedad y depresi�Qn en médicos de urgencias de Madrid durante la pandemia por el virus SARS-CoV-2
T2  - Emergencias
TI  - Niveles de ansiedad y depresi�Qn en médicos de urgencias de Madrid durante la pandemia por el virus SARS-CoV-2
TT  - Niveles de ansiedad y depresi�Qn en médicos de urgencias de Madrid durante la pandemia por el virus SARS-CoV-2.
Levels of anxiety and depression among emergency physicians in Madrid during the SARS-CoV-2 pandemic.
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812939
VL  - 32
ID  - 7788469
ER  - 

TY  - JOUR
AB  - The actual effectiveness of the still-to-come vaccination against the coronavirus SARS-CoV-2 might be challenged by vaccine hesitancy, a rather common and known phenomenon whose psychological predictors are, nevertheless, still largely debated. Our study aims at understanding how adult citizens' health engagement, perceived COVID-19 susceptibility and severity, and general vaccine-related attitudes affect the willingness to vaccinate against COVID-19. To that end, on a sample of Italian citizens, we implemented a path model to test the impact of health engagement on the willingness to vaccinate against SARS-CoV-2, and whether this relationship is direct or mediated by the general attitude towards vaccines and the risk perception. Moreover, we tested the configural and weak invariance of the model across gender and three age groups. Results show that health engagement is positively related to the intention to vaccinate and that this relationship is partially mediated by the general attitude towards vaccines. The model appears invariant across genders and partially invariant across age groups, showing some differences in the role of perceived susceptibility. These findings vouch for the implementation of educational campaigns aimed at sustaining future vaccination programs that also include health engagement promotion.
AD  - EngageMinds HUB-Consumer, Food & Health Engagement Research Center, 20123 Milan, Italy.
Department of Psychology, Università Cattolica del Sacro Cuore, Largo Gemelli 1, 20123 Milan, Italy.
Faculty of Agriculture, Food and Environmental Sciences, Università Cattolica del Sacro Cuore, via Milano 24, 26100 Cremona, Italy.
Section of Hygiene, Department of Health Sciences and Public Health, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.
Department of Woman and Child Health and Public Health, Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Faculty of Psychology, Università Cattolica del Sacro Cuore, 20123 Milan, Italy.
AN  - 33019663
AU  - Graffigna, G.
AU  - Palamenghi, L.
AU  - Boccia, S.
AU  - Barello, S.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/vaccines8040576
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Vaccines
KW  - Covid-19
SARS-CoV-2
health engagement
mediation model
path model
patient engagement
vaccine acceptance
vaccine attitude
vaccine hesitancy
LA  - eng
N1  - Graffigna, Guendalina
Orcid: 0000-0003-4378-7467
Palamenghi, Lorenzo
Orcid: 0000-0002-8222-3915
Boccia, Stefania
Barello, Serena
Orcid: 0000-0002-8514-2563
2018/2757/Fondazione Cariplo/
Journal Article
Switzerland
Vaccines (Basel). 2020 Oct 1;8(4):E576. doi: 10.3390/vaccines8040576.
PY  - 2020
SN  - 2076-393X (Print)
2076-393x
ST  - Relationship between Citizens' Health Engagement and Intention to Take the COVID-19 Vaccine in Italy: A Mediation Analysis
T2  - Vaccines
TI  - Relationship between Citizens' Health Engagement and Intention to Take the COVID-19 Vaccine in Italy: A Mediation Analysis
VL  - 8
ID  - 7785091
ER  - 

TY  - JOUR
AB  - Viral infections cause high morbidity and mortality, threaten public health, and impose a socioeconomic burden. We have seen the recent emergence of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2), the causative agent of COVID-19 that has already infected more than 29 million people, with more than 900,000 deaths since its identification in December 2019. Considering the significant impact of viral infections, research and development of new antivirals and control strategies are essential. In this paper, we summarise 96 antivirals approved by the Food and Drug Administration (FDA) between 1987 and 2019. Of these, 49 (51%) are used in treatments against human immunodeficiency virus (HIV), 4 against human papilloma virus (HPV), 6 against cytomegalovirus (CMV), 8 against hepatitis B virus (HBV), 5 against influenza, 6 against herpes simplex virus (HSV), 17 against hepatitis C virus (HCV), and 1 against respiratory syncytial virus (RSV). This review also describes future perspectives for new antiviral therapies such as nanotechnologies, monoclonal antibodies, and the CRISPR-Cas system. These strategies are suggested as inhibitors of viral replication by various means, such as direct binding to the viral particle, blocking the infection, changes in intracellular mechanisms or viral genes, preventing replication and virion formation. We also observed that a large number of viral agents have no therapy available and the majority of those approved in the last 32 years are restricted to some groups, especially anti-HIV. Additionally, the emergence of new viruses and strains resistant to available antivirals has necessitated the formulation of new antivirals.
AD  - Department of Microbiology, Biological Sciences Center, State University of Londrina, 86057970, Londrina, Brazil.
Department of Pathological Sciences, Biological Sciences Center, State University of Londrina, 86057970, Londrina, Brazil.
AN  - 33011993
AU  - Gonçalves, B. C.
AU  - Lopes Barbosa, M. G.
AU  - Silva Olak, A. P.
AU  - Belebecha Terezo, N.
AU  - Nishi, L.
AU  - Watanabe, M. A.
AU  - Marinello, P.
AU  - Zendrini Rechenchoski, D.
AU  - Dejato Rocha, S. P.
AU  - Faccin-Galhardi, L. C.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/fcp.12609
DP  - NLM
ET  - 2020/10/05
J2  - Fundamental & clinical pharmacology
KW  - Antivirals
CRISPR-Cas
Monoclonal Antibodies
Nanoparticles
LA  - eng
N1  - 1472-8206
Gonçalves, Bruna Carolina
Lopes Barbosa, M֙rio Gabriel
Silva Olak, Anna Paula
Belebecha Terezo, Natalia
Nishi, Leticia
Watanabe, Maria Angélica
Marinello, Poliana
Zendrini Rechenchoski, Daniele
Dejato Rocha, Sergio Paulo
Faccin-Galhardi, L�Tgia Carla
Orcid: 0000-0002-7522-9710
Journal Article
Review
England
Fundam Clin Pharmacol. 2020 Oct 4. doi: 10.1111/fcp.12609.
PY  - 2020
SN  - 0767-3981
ST  - Antiviral therapies: advances and perspectives
T2  - Fundamental & clinical pharmacology
TI  - Antiviral therapies: advances and perspectives
ID  - 7785633
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Remdesivir is a nucleotide analogue prodrug that inhibits viral RNA polymerases. It has been recognized recently as a promising antiviral drug against a wide array of RNA viruses (including SARS/MERS-CoV5). We aimed at determining which drugs used in dentistry interact with Remdesivir in order to avoid adverse reactions that may worsen the condition of patients with COVID-19. MATERIALS AND METHODS: A literature review was conducted to identify potential drug interactions between remdesivir (used in the treatment of COVID-19) and drugs prescribed in dentistry. The search was made in the databases PubMed and MEDLINE and official websites using key terms remdesivir, drug interactions and dentistry for articles published up to 31st July 2020. RESULTS: According to the articles reviewed, a total of 279 drugs interact with Remdesivir. Two major interactions have been reported, 277 moderate drug interactions, and one with alcohol/food. The drug interactions involving drugs prescribed in dentistry are all moderate drug interactions and are (according to drug group): (1) antibiotics: azithromycin, clavulanate, doxycycline, erythromycin, levofloxacin; (2) antifungals: clotrimazole, fluconazole, itraconazole, ketoconazole; (3) non-steroidal anti-inflammatories (NAIDS): celecoxib diclofenac, etodolac, flurbiprofen, ibuprofen, ketoprofen, ketorolac, mefenamic acid, naproxen, piroxicam. CONCLUSIONS: It is clinically necessary for oral health professionals to be aware of possible drug interactions that may occur between remdesivir and drugs commonly prescribed in dentistry in order to prevent adverse reactions that may even endanger the life of a patient with COVID-19.
AD  - Department of Medically Compromised Patients in Dentistry, School of Dentistry, University of Granada, Granada, Spain. ggomez@ugr.es.
AN  - 33015819
AU  - G�Qmez-Moreno, G.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23065
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
G�Qmez-Moreno, G
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9739-9743. doi: 10.26355/eurrev_202009_23065.
PY  - 2020
SN  - 1128-3602
SP  - 9739-9743
ST  - Remdesivir-COVID-19: drug interactions in dentistry
T2  - European review for medical and pharmacological sciences
TI  - Remdesivir-COVID-19: drug interactions in dentistry
VL  - 24
ID  - 7785246
ER  - 

TY  - JOUR
AB  - INTRODUCTION: Telemedicine provides remote clinical support through technology tools. It can facilitate medical care delivery while reducing unnecessary office visits. The COVID-19 outbreak has caused an abrupt change in our daily urological practice, where teleconsultations play a crucial role. OBJECTIVE: To provide practical recommendations for the effective use of technological tools in telemedicine. MATERIALS AND METHODS: A literature search was conducted on Medline until April 2020. We selected the most relevant articles related to �Jtelemedicine�� and �Jsmart working�� that could provide valuable information. RESULTS: Telemedicine refers to the use of electronic information and telecommunication tools to provide remote clinical health care support. Smart working is a working approach that uses new or existing technologies to improve performance. Telemedicine is becoming a useful and fundamental tool during the COVID-19 pandemic and will be even more in the future. It is time for us to officially give telemedicine the place it deserves in clinical practice, and it is our responsibility to adapt and familiarize with all the tools and possible strategies for its optimal implementation. We must guarantee that the quality of care received by patients and perceived by them and their families is of the highest standard. CONCLUSIONS: Telemedicine facilitates remote specialized urological clinical support and solves problems caused by limited patient mobility or transfer, reduces unnecessary visits to clinics and is useful to reduce the risk of COVID-19 viral transmission.
AD  - Servicio de Urolog�Ta, Hospital Universitario La Paz, Madrid, España; Young Academic Urologist-Urotechnology working party (ESUT-YAU), European Association of Urology, Arnhem, Pa�Tses Bajos. Electronic address: juangomezr@gmail.com.
Servicio de Urolog�Ta, Hospital Universitario La Paz, Madrid, España.
Department of Urology and Population Health, New York University and Manhattan Veterans Affairs, New York, EE. UU.
S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong.
Servicio de Urolog�Ta, Hospital Clinic, Universidad de Barcelona, Barcelona, España.
European Association of Urology, Arnhem, Pa�Tses Bajos.
Academic Urology Unit, University of Sheffield, Sheffield, UK.
Academic Urology Unit, University of Aberdeen, Aberdeen, UK.
Department of Urology, Katholieke University, Leuven, Bélgica.
Servicio de Urolog�Ta, Hospital Universitario Gregorio Marañon, Madrid, España.
Servicio de Urolog�Ta, Hospital Nacional de Parapléjicos, Toledo, España.
Instituto de Cirug�Ta Urol�Qgica Avanzada (ICUA), Madrid, España.
AN  - 33012592
AU  - G�Qmez Rivas, J.
AU  - Rodr�Tguez-Serrano, A.
AU  - Loeb, S.
AU  - Yuen-Chun Teoh, J.
AU  - Ribal, M. J.
AU  - Bloemberg, J.
AU  - Catto, J.
AU  - ŃDow, J.
AU  - van Poppel, H.
AU  - Gonz֙lez, J.
AU  - Esteban, M.
AU  - Rodriguez Socarr֙s, M.
C1  - 10/6/2020
DA  - Sep 11
DB  - PubMed
DO  - 10.1016/j.acuro.2020.08.010
DP  - NLM
ET  - 2020/10/06
J2  - Actas urologicas espanolas
KW  - Covid-19
Redes sociales
Smart working
Social media
Telehealth
Telemedicina
Telemedicine
Telesalud
Teletrabajo
Teleworking
Trabajo inteligente
Video consultation
Videoconsulta
LA  - eng
spa
N1  - 1699-7980
G�Qmez Rivas, J
Rodr�Tguez-Serrano, A
Loeb, S
Yuen-Chun Teoh, J
Ribal, M J
Bloemberg, J
Catto, J
ŃDow, J
van Poppel, H
Gonz֙lez, J
Esteban, M
Rodriguez Socarr֙s, M
Journal Article
Review
Spain
Actas Urol Esp. 2020 Sep 11:S0210-4806(20)30195-9. doi: 10.1016/j.acuro.2020.08.010.
OP  - Telemedicina y trabajo inteligente: adaptaci�Qn al español de las recomendaciones de la Asociaci�Qn Europea de Urolog�Ta.
PY  - 2020
SN  - 0210-4806
ST  - Telemedicine and smart working: Spanish adaptation of the European Association of Urology recommendations
T2  - Actas urologicas espanolas
TI  - Telemedicine and smart working: Spanish adaptation of the European Association of Urology recommendations
ID  - 7785568
ER  - 

TY  - JOUR
AU  - Gomez, Juan-Pedro
AU  - Mironov, Maxim
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - COVID-19, soccer, super-spreaders, instrumental variables, identification strategy
PY  - 2020
ST  - Using Soccer Games as an Instrument to Forecast the Spread of COVID-19 in Europe (preprint)
T2  - SSRN
TI  - Using Soccer Games as an Instrument to Forecast the Spread of COVID-19 in Europe (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3701022
ID  - 7788896
ER  - 

TY  - JOUR
AB  - INTRODUCTION: Despite the current interest caused by SARS-Cov-2, influenza continues to be one of the most serious health concerns, with an estimated 1 billion cases of influenza across the globe, including 3-5 million severe cases and 290,000-650,000 deaths worldwide. AREAS COVERED: This manuscript reviews the efforts made in the development of small molecules for the treatment of influenza virus, primarily focused on patent applications in the last five years. Attention is paid to compounds targeting key functional viral proteins, such as the M2 channel, neuraminidase, and hemagglutinin, highlighting the evolution toward novel ligands and scaffolds motivated by the emergence of resistant strains. Finally, the discovery of compounds against novel viral targets, such as the RNA-dependent RNA polymerase, is discussed. EXPERT OPINION: The therapeutic potential of antiviral agents is limited by the increasing presence of resistant strains. This should encourage research on novel strategies for therapeutic intervention. In this context, the discovery of arbidol and JNJ7918 against hemagglutinin, and current efforts on RNA-dependent RNA polymerase have disclosed novel opportunities for therapeutic treatment. Future studies should attempt to expand the therapeutic arsenal of anti-flu agents, often in combined therapies, which might be relevant to prevent future health challenges caused by influenza virus.
AD  - Translational Medicinal and Biological Chemistry group, Centro de investigaciones Biol�Qgicas Margarita Salas, Consejo Superior de Investigaciones Biol�Qgicas (CIB-CSIC) , Madrid E-28040, Spain.
Department of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy and Food Sciences, Institute of Biomedicine (IBUB), and Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona , Santa Coloma de Gramanet E-08921, Spain.
AN  - 33012213
AU  - Ginex, T.
AU  - Luque, F. J.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/13543776.2020.1831471
DP  - NLM
ET  - 2020/10/06
J2  - Expert opinion on therapeutic patents
KW  - M2 proton channel
RNA polymerase
antivirals
drug discovery
druggable targets
hemagglutinin
influenza
neuraminidase
LA  - eng
N1  - 1744-7674
Ginex, Tiziana
Orcid: 0000-0002-5739-8713
Luque, F Javier
Orcid: 0000-0002-8049-3567
Journal Article
England
Expert Opin Ther Pat. 2020 Oct 5. doi: 10.1080/13543776.2020.1831471.
PY  - 2020
SN  - 1354-3776
ST  - Searching for effective antiviral small molecules against influenza A virus: A patent review
T2  - Expert opinion on therapeutic patents
TI  - Searching for effective antiviral small molecules against influenza A virus: A patent review
ID  - 7785612
ER  - 

TY  - JOUR
AD  - Section Editor Health Policy Processes, Health Policy and Systems Division, University of Cape Town, South Africa.
Section Editor Health Systems Research, Health Policy and Planning and Institute of Tropical Medicine, Belgium.
Ghana Health Service, Ghana.
Kenya Medical Research Institute-Wellcome Trust Research Programme, Nairobi, Kenya.
Centre de Recherche en Reproduction Humaine et en Démographie (CERRHUD), Benin.
Health Systems Global and University of the Western Cape, South Africa.
Benguet State University, The Philippines.
University of Buenos Aires, Argentina.
Kenya Medical Research Institute-Wellcome Trust Research Programme, Kilifi, Kenya and Oxford University, UK.
Institute of Public Health, Bengaluru, India.
University of the Western Cape, South Africa.
Section Editor Health Policy Processes, Health Policy and Planning and Johns Hopkins University, USA.
Section Editor Health Systems Research, Health Policy and Planning and Alliance for Health Policy and Systems Research, Geneva, Switzerland.
Section Editor Health Systems Research, Health Policy and Planning and London School of Hygiene and Tropical Medicine, UK.
Institute of Tropical Medicine, Belgium.
University of Cape Town, South Africa.
AN  - 33020815
AU  - Gilson, L.
AU  - Marchal, B.
AU  - Ayepong, I.
AU  - Barasa, E.
AU  - Dossou, J. P.
AU  - George, A.
AU  - Guinaran, R.
AU  - Maceira, D.
AU  - Molyneux, S.
AU  - Prashanth, N. S.
AU  - Schneider, H.
AU  - Shawar, Y.
AU  - Shiffman, J. R.
AU  - Sheikh, K.
AU  - Spicer, N.
AU  - Van Belle, S.
AU  - Whyle, E.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/heapol/czaa112
DP  - NLM
ET  - 2020/10/07
J2  - Health policy and planning
LA  - eng
N1  - 1460-2237
Gilson, Lucy
Marchal, Bruno
Ayepong, Irene
Barasa, Edwine
Dossou, Jean-Paul
George, Asha
Guinaran, Ryan
Maceira, Daniel
Molyneux, Sassy
Prashanth, N S
Schneider, Helen
Shawar, Yusra
Shiffman, Jeremy R
Sheikh, Kabir
Spicer, Neil
Van Belle, Sara
Whyle, Eleanor
Journal Article
England
Health Policy Plan. 2020 Oct 6:czaa112. doi: 10.1093/heapol/czaa112.
PY  - 2020
SN  - 0268-1080
ST  - What role can health policy and systems research play in supporting responses to COVID-19 that strengthen socially just health systems?
T2  - Health policy and planning
TI  - What role can health policy and systems research play in supporting responses to COVID-19 that strengthen socially just health systems?
ID  - 7784976
ER  - 

TY  - JOUR
AB  - Effective and affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are needed. We report in vitro efficacy of Artemisia annua extracts as well as artemisinin, artesunate, and artemether against SARS-CoV-2. The latter two are approved active pharmaceutical ingredients of anti-malarial drugs. Proof-of-concept for prophylactic efficacy of the extracts was obtained using a plaque-reduction assay in VeroE6 cells. Subsequent concentration-response studies using a high-throughput antiviral assay, based on immunostaining of SARS-CoV-2 spike glycoprotein, revealed that pretreatment and treatment with extracts, artemisinin, and artesunate inhibited SARS-CoV-2 infection of VeroE6 cells. In treatment assays, artesunate (50% effective concentration (EC50): 7 μg/mL) was more potent than the tested plant extracts (128-260 μg/mL) or artemisinin (151 μg/mL) and artemether (&amp;gt;179 μg/mL), while generally EC50 in pretreatment assays were slightly higher. The selectivity index (SI), calculated based on treatment and cell viability assays, was highest for artemisinin (54), and roughly equal for the extracts (5-10), artesunate (6) and artemether (&amp;lt;7). Similar results were obtained in human hepatoma Huh7.5 cells. Peak plasma concentrations of artesunate exceeding EC50 values can be achieved. Clinical studies are required to further evaluate the utility of these compounds as COVID-19 treatment.Competing Interest StatementK.G. is the director of ArtemiLife, Inc. K.G. and P.H.S. have a significant financial stake in ArtemiFlow GmbH, that is a shareholder in ArtemiLife, Inc.
AU  - Gilmore, Kerry
AU  - Zhou, Yuyong
AU  - Ramirez, Santseharay
AU  - Pham, Long V.
AU  - Fahnoe, Ulrik
AU  - Feng, Shan
AU  - Offersgaard, Anna
AU  - Trimpert, Jakob
AU  - Bukh, Jens
AU  - Osterrieder, Klaus
AU  - Gottwein, Judith
AU  - Seeberger, Peter H.
C1  - 10/6/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.05.326637
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.05.326637
ST  - In vitro efficacy of Artemisinin-based treatments against SARS-CoV-2 (preprint)
T2  - bioRxiv
TI  - In vitro efficacy of Artemisinin-based treatments against SARS-CoV-2 (preprint)
UR  - http://biorxiv.org/content/early/2020/10/05/2020.10.05.326637.abstract
ID  - 7788882
ER  - 

TY  - JOUR
AB  - The COVID-19 Open Research Dataset (CORD-19) was released in March 2020 to allow the machine learning and wider research community to develop techniques to answer scientific questions on COVID-19. The data set consists of a large collection of scientific literature, including over 100,000 full text papers. Annotating training data to normalise variability in biological entities can improve the performance of downstream analysis and interpretation. To facilitate and enhance the use of the CORD-19 data in these applications, in late March 2020 we performed a comprehensive annotation process using named entity recognition tool, TERMite, along with a number of large reference ontologies and vocabularies including domains of genes, proteins, drugs and virus strains. The additional annotation has identified and tagged over 45 million entities within the corpus made up of 62,746 unique biomedical entities. The latest updated version of the annotated data, as well as older versions, is made openly available under GPL-2.0 License for the community to use at: https://github.com/SciBiteLabs/CORD19 .Competing Interest StatementThe authors have declared no competing interest.
AU  - Giles, Oliver
AU  - Huntley, Rachael
AU  - Karlsson, Anneli
AU  - Lomax, Jane
AU  - Malone, James
C1  - 10/6/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.04.325266
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.04.325266
ST  - Reference ontology and database annotation of the COVID-19 Open Research Dataset (CORD-19) (preprint)
T2  - bioRxiv
TI  - Reference ontology and database annotation of the COVID-19 Open Research Dataset (CORD-19) (preprint)
UR  - http://biorxiv.org/content/early/2020/10/05/2020.10.04.325266.abstract
ID  - 7788880
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19) pandemic created a significant impact on medically assisted reproduction (MAR) services. ESHRE decided to mobilize resources in order to collect, analyse, monitor, prepare and disseminate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) knowledge specifically related to ART and early pregnancy. This paper presents the impact of the SARS-CoV-2 pandemic focusing on reproductive healthcare. It details the rationale behind the guidance prepared to support MAR services in organizing and managing the re-start of treatments or in case of any future wave of COVID-19 disease. The guidance includes information on patient selection and informed consent, staff and patient triage and testing, adaptation of ART services, treatment planning and code of conduct. The initiatives detailed in this manuscript are not necessarily COVID-specific and such action plans could be applied effectively to manage similar emergency situations in different areas of medicine, in the future.
AD  - Società Italiana Studi di Medicina della Riproduzione, S.I.S.Me.R. Reproductive medicine institute, Bologna, Emilia-Romagna, IT.
Koc University, Obstetrics and Gynecology Dept, Koc University, Davutpasa Cad. No : 4, Istanbul, TR.
Reproductive Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden.
Fertility Europe Evere, Be.
Department of Obstetrics and Gynaecology, University of Helsinki and Helsinki University Hospital, Haartmaninkatu 2, PO 140, 00029, Helsinki, Finland; Department of Obstetrics and Gynaecology, University of Oulu, Oulu University Hospital and Medical Research Centre, PEDEGO Research Unit, Kajaanintie 50, PO 5000, Oulu, Finland.
ESHRE Central office, Grimbergen, Belgium.
Reproductive Medicine Service. Dexeus Mujer. Hospital Universitari Dexeus/Institut d'Investigaci�Q Biom؈dica de Bellvitge. IDIBELL, Barcelona Stem Cell Bank. Regenerative Medicine Programme. Barcelona, ES.
Rotunda Hospital and Royal College of Surgeons in Ireland, Parnell Square, Dublin, 1, IE.
AN  - 33017461
AU  - Gianaroli, L.
AU  - Ata, B.
AU  - Lundin, K.
AU  - Rautakallio-Hokkanen, S.
AU  - Tapanainen, J. S.
AU  - Vermeulen, N.
AU  - Veiga, A.
AU  - Mocanu, E.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1093/humrep/deaa285
DP  - NLM
ET  - 2020/10/06
J2  - Human reproduction (Oxford, England)
KW  - ART services
Covid-19
Ivf
SARS-CoV-2
coronavirus disease 2019
medically assisted reproduction
pandemic
severe acute respiratory syndrome coronavirus 2
testing
triage
LA  - eng
N1  - 1460-2350
ESHRE COVID-19 Working Group
Gianaroli, Luca
Ata, Baris
Lundin, Kersti
Rautakallio-Hokkanen, Satu
Tapanainen, Juha S
Vermeulen, Nathalie
Veiga, Anna
Mocanu, Edgar
Journal Article
England
Hum Reprod. 2020 Oct 5:deaa285. doi: 10.1093/humrep/deaa285.
PY  - 2020
SN  - 0268-1161
ST  - The calm after the storm: re-starting ART treatments safely in the wake of the COVID-19 pandemic
T2  - Human reproduction (Oxford, England)
TI  - The calm after the storm: re-starting ART treatments safely in the wake of the COVID-19 pandemic
ID  - 7785132
ER  - 

TY  - JOUR
AB  - Given the nature of heart disease and the importance of continuing heart surgery during the pandemic and its aftermath and in order to provide adequate safety for the surgical team and achieve the desired result for patients, as well as the optimal use of ICU beds, the medical team, blood, blood products, and personal protective equipment, it is essential to change the usual approach during the pandemic. There are still a lot of evidences and experiences needed to produce the perfect protocol. Some centers may have a special program for their centers during this period of epidemics that can be respected and performed. Generally, in pandemic conditions, the use of non-surgical approaches is preferred if similar outcomes can be obtained. Copyright © 2020 The Author (s).
AD  - (Ghavidel, Hoseini) Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran, Islamic Republic of (Mirzaaghayan, Radmehr) Department of Cardiac Surgery, Tehran Children Hospital, Tehran University of Medical Science, Tehran, Iran, Islamic Republic of (Yousefnia) Department of Cardiac Surgery, Day General Hospital, Tehran, Iran, Islamic Republic of (Asdaghpour) Department of Cardiac Surgery, Shahid Chamran Hospital, Tehran, Iran, Islamic Republic of (Tehrani, Aval, Hekmat) Department of Cardiac Surgery, Shahid Moddares Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran, Islamic Republic of (Jalilifar) Department of Cardiac Surgery, Rasoul Akram Hospital, Iran University of Medical Science, Tehran, Iran, Islamic Republic of (Shirzad, Ahmadi) Department of Cardiac Surgery, Tehran Heart Center, Tehran University of Medical Science, Tehran, Iran, Islamic Republic of (Austine) Editoral Office, Iranian Society of Cardiac Surgeons, Tehran, Iran, Islamic Republic of (Ahmadi, Jadbabaei) Department of Cardiac Surgery, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran, Islamic Republic of (Rad, Parvizi) Cardiovascular Research Center, Tabriz University of Medical Science, Tabriz, Iran, Islamic Republic of (Amirghofran) Department of Cardiac Surgery, Shahid Faghihi Hospital, Shiraz University of Medical Science, Shiraz, Iran, Islamic Republic of (Amin) Department of Cardiology, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran, Islamic Republic of (Babazadeh) Department of Cardiac Surgery, Milad General Hospital, Tehran, Iran, Islamic Republic of (Bakhshandeh, Salehi) Department of Cardiac Surgery, Imam Khomeini Medical Center, Tehran University of Medical Science, Tehran, Iran, Islamic Republic of (Baharestani, Dahaki) Department of Cardiac Surgery, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran, Islamic Republic of (Jahangirifard) Lung Transplantation Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of (Heidari) Department of Cardiac Surgery, Golestan Hospital, Ahvaz University of Medical Science, Ahvaz, Iran, Islamic Republic of (Shabani) Department of Infectious Disease, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran, Islamic Republic of (Sadeghipour, Firouzi) Cardiovascular Intervention Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of (Tabari) Department of Cardiac Surgery, Fatemeh Zahra Hospital, Mazandaran University of Medical Science, Sari, Iran, Islamic Republic of (Abbasi) Department of Cardiac Surgery, Imam Reza Hospital, Mashhad University of Medical Science, Mashhad, Iran, Islamic Republic of (Laali) Department of Cardiac Surgery, La Pitie-salpetrier Hospital, Paris, France (Mandegar) Department of Cardiac Surgery, Shariati Hospital, Tehran University of Medical Science, Tehran, Iran, Islamic Republic of (Mirmohammadsadeghi) Department of Cardiac Surgery, Shahid Chamran Hospital, Isfahan University of Medical Science, Isfahan, Iran, Islamic Republic of (Shirazi) Department of Cardiac Surgery, Laleh Hospital, Tehran, Iran, Islamic Republic of (Nikpajooh) Department of Social Medicine, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran, Islamic Republic of
A.A. Ghavidel, Heart Valve Disease Research Center, Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Science, Tehran, Iran, Islamic Republic of. E-mail: aaghavidel@gmail.com
AN  - 632979985
AU  - Ghavidel, A. A.
AU  - Mirzaaghayan, M.
AU  - Yousefnia, M. A.
AU  - Asdaghpour, E.
AU  - Tehrani, R. B.
AU  - Jalilifar, N.
AU  - Radmehr, H.
AU  - Shirzad, M.
AU  - Austine, N.
AU  - Ahmadi, H.
AU  - Ahmadi, Z. H.
AU  - Rad, A. A.
AU  - Amirghofran, A.
AU  - Amin, A.
AU  - Aval, Z. A.
AU  - Babazadeh, K.
AU  - Bakhshandeh, A.
AU  - Baharestani, B.
AU  - Parvizi, R.
AU  - Jadbabaei, A.
AU  - Jahangirifard, A.
AU  - Hoseini, S.
AU  - Hekmat, M.
AU  - Heidari, A.
AU  - Shabani, M.
AU  - Sadeghipour, P.
AU  - Salehi, M.
AU  - Tabari, S. Z.
AU  - Abbasi, M.
AU  - Dahaki, M. G.
AU  - Firouzi, A.
AU  - Laali, M.
AU  - Mandegar, M. H.
AU  - Mirmohammadsadeghi, M.
AU  - Shirazi, M. N.
AU  - Nikpajooh, A.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.34172/jcvtr.2020.28
DP  - Ovid Technologies
IS  - 3
KW  - Cardiac Surgery
Corona
covid-19
covid-19 ppe
SARS-CoV-2
Task Force
adult
cardiac surgeon
coronavirus disease 2019
drug safety
elective surgery
epidemic
heart disease
heart surgery
human
pandemic
protective equipment
review
surgery
LA  - English
M3  - Review
PY  - 2020
SN  - 2008-5117
2008-6830
SP  - 158-164
ST  - Iranian society of cardiac surgeons COVID-19 task force version II, restarting elective surgeries
T2  - Journal of Cardiovascular and Thoracic Research
TI  - Iranian society of cardiac surgeons COVID-19 task force version II, restarting elective surgeries
UR  - http://jcvtr.tbzmed.ac.ir/
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632979985
VL  - 12
ID  - 7782915
ER  - 

TY  - JOUR
AD  - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran, morteza.ghasemnejad@yahoo.com.
Department of Pediatrics, Faculty of Medicine, Motahari Hospital, Urmia University of Medical Sciences, Urmia, Iran.
AN  - 33011728
AU  - Ghasemnejad-Berenji, M.
AU  - Pashapour, S.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1159/000511280
DP  - NLM
ET  - 2020/10/05
J2  - Pharmacology
KW  - Covid-19
RNA viruses
Raf/MEK/ERK signaling
Viral life cycle
Viral survival
LA  - eng
N1  - 1423-0313
Ghasemnejad-Berenji, Morteza
Pashapour, Sarvin
Journal Article
Switzerland
Pharmacology. 2020 Oct 2:1-3. doi: 10.1159/000511280.
PY  - 2020
SN  - 0031-7012
SP  - 1-3
ST  - SARS-CoV-2 and the Possible Role of Raf/MEK/ERK Pathway in Viral Survival: Is This a Potential Therapeutic Strategy for COVID-19?
T2  - Pharmacology
TI  - SARS-CoV-2 and the Possible Role of Raf/MEK/ERK Pathway in Viral Survival: Is This a Potential Therapeutic Strategy for COVID-19?
ID  - 7785659
ER  - 

TY  - JOUR
AB  - OBJECTIVE: During the COVID-19 pandemic, it is essential to understand if and how to screen SARS-CoV-2-positive athletes to safely resume training and competitions. The aim of this study is to understand which investigations are useful in a screening protocol aimed at protecting health but also avoiding inappropriate examinations. METHODS: We conducted a cohort study of a professional soccer team that is based on an extensive screening protocol for resuming training during the COVID-19 pandemic. It included personal history, antigen swabs, blood tests, spirometry, resting/stress-test ECG with oxygen saturation monitoring, echocardiogram, Holter and chest CT. We also compared the findings with prior data from the same subjects before infection and with data from SARS-CoV-2-negative players. RESULTS: None of the players had positive swab and/or anti-SARS-CoV-2 IgM class antibodies. Out of 30 players, 18 (60%) had IgG class antibodies. None had suffered severe SARS-CoV-2-related disease, 12 (66.7%) had complained of mild COVID-19-related symptoms and 6 (33.3%) were asymptomatic. None of the players we examined revealed significant cardiovascular abnormalities after clinical recovery. A mild reduction in spirometry parameters versus pre-COVID-19 values was observed in all athletes, but it was statistically significant (p0.05) only in SARS-CoV-2-positive athletes. One SARS-CoV-2-positive player showed increased troponin I level, but extensive investigation did not show signs of myocardial damage. CONCLUSION: In this small cohort of athletes with previous asymptomatic/mild SARS-CoV-2 infection, a comprehensive screening protocol including blood tests, spirometry, resting ECG, stress-test ECG with oxygen saturation monitoring and echocardiogram did not identify relevant anomalies. While larger studies are needed, extensive cardiorespiratory and haematological screening in athletes with asymptomatic/mild SARS-CoV-2 infection appears unnecessary.
AD  - Sports Medicine Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy gervasi.salvatore.md@gmail.com.
Sports Medicine Unit, Catholic University of the Sacred Heart Faculty of Medicine and Surgery, Roma, Lazio, Italy.
Sports Medicine Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Department of Emergency Radiology, University Hospital Careggi, Firenze, Toscana, Italy.
Diagnostic Imaging Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
Department of Experimental and Clinical Medicine, University Hospital Careggi, Firenze, Toscana, Italy.
Synlab Med, Sesto Fiorentino, Florence, Italy.
AN  - 33020140
AU  - Gervasi, S. F.
AU  - Pengue, L.
AU  - Damato, L.
AU  - Monti, R.
AU  - Pradella, S.
AU  - Pirronti, T.
AU  - Bartoloni, A.
AU  - Epifani, F.
AU  - Saggese, A.
AU  - Cuccaro, F.
AU  - Bianco, M.
AU  - Zeppilli, P.
AU  - Palmieri, V.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/bjsports-2020-102789
DP  - NLM
ET  - 2020/10/07
J2  - British journal of sports medicine
KW  - athlete
exercise testing
heart disease
prevention
soccer
LA  - eng
N1  - 1473-0480
Gervasi, Salvatore Francesco
Orcid: 0000-0002-8933-6955
Pengue, Luca
Damato, Luca
Monti, Riccardo
Pradella, Silvia
Pirronti, Tommaso
Bartoloni, Alessandro
Epifani, Francesco
Saggese, Alessio
Cuccaro, Francesco
Bianco, Massimiliano
Zeppilli, Paolo
Palmieri, Vincenzo
Journal Article
England
Br J Sports Med. 2020 Oct 5:bjsports-2020-102789. doi: 10.1136/bjsports-2020-102789.
PY  - 2020
SN  - 0306-3674
ST  - Is extensive cardiopulmonary screening useful in athletes with previous asymptomatic or mild SARS-CoV-2 infection?
T2  - British journal of sports medicine
TI  - Is extensive cardiopulmonary screening useful in athletes with previous asymptomatic or mild SARS-CoV-2 infection?
ID  - 7785048
ER  - 

TY  - JOUR
AB  - This short note is a response to John Spry’s critique of our research letter “Association of Stay-at-Home Orders With COVID-19 Hospitalizations in 4 States,�?which appeared in Journal of the American Medical Association in 2020. We also provide an example from a state that did not have a stay-at-home order that is consistent with the findings of our original paper.
AN  - 2448233052
AU  - Georgiou, Archelle
C1  - 10/6/2020
DA  - Sep 2020
2020-10-05
DB  - ProQuest Central
DP  - ProQuest Central
IS  - 2
KW  - Business And Economics--Economic Systems And Theories, Economic History
pandemic
coronavirus
exponential growth
Shelter in place
Coronaviruses
COVID-19
LA  - English
N1  - Copyright - Copyright Fraser Institute Sep 2020
PY  - 2020
SP  - 279-281
ST  - Reply to John Spry on Stay-at-Home Orders and COVID-19 Hospitalizations
T2  - Econ Journal Watch
TI  - Reply to John Spry on Stay-at-Home Orders and COVID-19 Hospitalizations
UR  - https://www.proquest.com/docview/2448233052?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Reply+to+John+Spry+on+Stay-at-Home+Orders+and+COVID-19+Hospitalizations&title=Econ+Journal+Watch&issn=&date=2020-09-01&volume=17&issue=2&spage=279&au=Georgiou%2C+Archelle&isbn=&jtitle=Econ+Journal+Watch&btitle=&rft_id=info:eric/&rft_id=info:doi/
VL  - 17
ID  - 7784902
ER  - 

TY  - JOUR
AU  - Geiringer, Claudia
AU  - Geddis, Andrew
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - COVID-19, New Zealand Bill of Rights Act, ultra vires, unlawful declaration, declaratory relief, principles of legality, emergency powers, judicial deference
PY  - 2020
ST  - Judicial Deference and Emergency Power: A Perspective on Borrowdale V Director-General (preprint)
T2  - SSRN
TI  - Judicial Deference and Emergency Power: A Perspective on Borrowdale V Director-General (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693450
ID  - 7788907
ER  - 

TY  - JOUR
AN  - 146168423
AU  - Gaspari, V.
AU  - Neri, I.
AU  - Misciali, C.
AU  - Patrizi, A.
C1  - 10/6/2020
DB  - a9h
DO  - 10.1111/jdv.16693
DP  - EBSCOhost
IS  - 10
KW  - COVID-19
SARS-CoV-2
CORONAVIRUS diseases
SYMPTOMS
VIRUS diseases
BOLOGNA (Italy)
ITALY
M3  - Article
N1  - Gaspari, V. 1; Email Address: valeria.gaspari@aosp.bo.it Neri, I. 1 Misciali, C. 1 Patrizi, A. 1; Affiliation: 1: Unit of Dermatology, Head and Neck Department, St. Orsola Malpighi University Hospital, Bologna, Italy; Source Info: Oct2020, Vol. 34 Issue 10, pe552; Subject Term: COVID-19; Subject Term: SARS-CoV-2; Subject Term: CORONAVIRUS diseases; Subject Term: SYMPTOMS; Subject Term: VIRUS diseases; Subject Term: BOLOGNA (Italy); Subject Term: ITALY; Number of Pages: 2p; Document Type: Article; Full Text Word Count: 998
PY  - 2020
SN  - 09269959
SP  - e552-e553
ST  - COVID�?9: how it can look on the skin. Clinical and pathological features in 20 COVID�?9 patients observed in Bologna, north‐eastern Italy
T2  - Journal of European Academy of Dermatology & Venereology
TI  - COVID�?9: how it can look on the skin. Clinical and pathological features in 20 COVID�?9 patients observed in Bologna, north‐eastern Italy
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146168423&site=ehost-live
VL  - 34
ID  - 7783889
ER  - 

TY  - JOUR
AD  - Departamento de Cardiolog�Ta, Hospital Puerta de Hierro, Majadahonda, Madrid, España.
AN  - 33012952
AU  - Garc�Ta-Rodr�Tguez, D.
AU  - Pérez, P. R.
AU  - Garc�Ta-Izquierdo, E.
AU  - Ramos, J. T.
AU  - Urda, V. C.
AU  - Lozano, I. F.
C1  - 10/6/2020
C2  - PMC7524683
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.recesp.2020.09.021
DP  - NLM
ET  - 2020/10/06
J2  - Revista espanola de cardiologia
LA  - spa
N1  - 1579-2242
Garc�Ta-Rodr�Tguez, Daniel
Pérez, Paloma Remior
Garc�Ta-Izquierdo, Eusebio
Ramos, Jorge Toquero
Urda, V�Tctor Castro
Lozano, Ignacio Fern֙ndez
Case Reports
Rev Esp Cardiol. 2020 Sep 30. doi: 10.1016/j.recesp.2020.09.021.
OP  - Prolongaci�Qn del intervalo QT por f֙rmacos en la neumon�Ta por COVID-19: influencia en la supervivencia durante el ingreso.
PY  - 2020
SN  - 0300-8932 (Print)
0300-8932
ST  - [Drug-induced QT prolongation in COVID-19 pneumonia: influence on in-hospital survival]
T2  - Revista espanola de cardiologia
TI  - [Drug-induced QT prolongation in COVID-19 pneumonia: influence on in-hospital survival]
ID  - 7785526
ER  - 

TY  - JOUR
AB  - In this paper, we investigate a specific structure within the theoretical framework of Partition Markov Models (PMM) [see Garc�Ta Jesús and Gonz֙lez-L�Qpez, Entropy 19, 160 (2017)]. The structure of interest lies in the formulation of the underlying partition, which defines the process, in which, in addition to a finite memory o associated with the process, a parameter G is introduced, allowing an extra dependence on the past complementing the dependence given by the usual memory o. We show, by simulations, how algorithms designed for the classic version of the PMM can have difficulties in recovering the structure investigated here. This specific structure is efficient for modeling a complete genome sequence, coming from the newly decoded Coronavirus Covid-19 in humans [see Wu et al., Nature 579, 265�?69 (2020)]. The sequence profile is represented by 13 units (parts of the state space’s partition), for each of the 13 units, their respective transition probabilities are computed for any element of the genetic alphabet. Also, the structure proposed here allows us to develop a comparison study with other genomic sequences of Coronavirus, collected in the last 25 years, through which we conclude that Covid-19 is shown next to SARS-like Coronaviruses (SL-CoVs) from bats specimens in Zhoushan [see Hu et al., Emerg Microb Infect 7, 1�?0 (2018)].
AN  - 2448239003
AU  - Garc�Ta, Jesús Enrique
AU  - Gonz֙lez-L�Qpez, Ver�Qnica Andrea
AU  - Tasca, Gustavo Henrique
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1051/fopen/2020013
DP  - ProQuest Central
KW  - Sciences: Comprehensive Works
Bayesian information criterion
Partition Markov Models
Metric between Markov processes
Probability
Stochastic models
Zika virus
Algorithms
Coronaviruses
Markov analysis
COVID-19
LA  - English
N1  - Copyright - © 2020. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SP  - 13
ST  - Partition Markov Model for Covid-19 Virus
T2  - 4open
TI  - Partition Markov Model for Covid-19 Virus
UR  - https://www.proquest.com/docview/2448239003?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Apubliccontent&atitle=Partition+Markov+Model+for+Covid-19+Virus&title=4open&issn=&date=2020-01-01&volume=3&issue=&spage=13&au=Garc%C3%ADa%2C+Jes%C3%BAs+Enrique%3BGonz%C3%A1lez-L%C3%B3pez%2C+Ver%C3%B3nica+Andrea%3BTasca%2C+Gustavo+Henrique&isbn=&jtitle=4open&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1051%2Ffopen%2F2020013
VL  - 3
ID  - 7784948
ER  - 

TY  - JOUR
AB  - AIM: The present study was conducted to assess the perceived risk of COVID-19 transmission in dental professionals (DPs), that include dentists and dental auxiliary staffs, and whether rapid tests should be a recommended tool to constrain the transmission of the COVID-19, and who should be bearing their cost (governments, dentists, or patients) through an online survey. MATERIALS AND METHODS: A sample size of n = 700 was recruited in the study. The study included DPs from all over the world. A randomized selection of samples was done through dental groups present on social networks. An online survey was conducted in April 2020, using the Google Form software to provide questions and collect and elaborate answers. Data were analyzed using the statistical software STATA and presented in terms of percentages. RESULTS: About 78% of the study participants perceived a very high risk of COVID-19 contamination in dental settings. Nearly 80% of the study participants were willing to be subjected to rapid tests and the same could be performed on patients visiting their dental clinics, which could prevent the spread of the disease. About 55% of the participants had reported that additional costs for the rapid tests should be borne by the governments. CONCLUSION: The results of the present survey report that DPs do not feel safe and perceive a high risk of COVID-19 contagion and prevention of the disease could be done by performing rapid tests on dentists, dental staff, and patients visiting the dental clinics irrespective of age and gender of the participants. SIGNIFICANCE: Since all the dentists and allied staff have perceived increased risk for COVID-19 transmission, it is important that preventive measures are implemented through rapid test kits at the earliest.
AD  - Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy.
Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, Italy, Phone: +39 3393935527, e-mail: dario.dinardo@uniroma1.it.
Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.
Department of Restorative Dental Sciences, Division of Operative Dentistry, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia.
Department of Therapeutic Dentistry, IM Sechenov First Moscow State Medical University, Moscow, Russia.
AN  - 33020352
AU  - Gambarini, E.
AU  - Galli, M.
AU  - Di Nardo, D.
AU  - Miccoli, G.
AU  - Patil, S.
AU  - Bhandi, S.
AU  - Giovarruscio, M.
AU  - Testarelli, L.
AU  - Gambarini, G.
C1  - 10/6/2020
DA  - Jul 1
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 7
J2  - The journal of contemporary dental practice
KW  - Covid-19
Coronavirus
Dental practice Dentistry.
LA  - eng
N1  - 1526-3711
Gambarini, Elisa
Galli, Massimo
Di Nardo, Dario
Miccoli, Gabriele
Patil, Shankargouda
Bhandi, Shilpa
Giovarruscio, Massimo
Testarelli, Luca
Gambarini, Gianluca
Journal Article
India
J Contemp Dent Pract. 2020 Jul 1;21(7):718-722.
PY  - 2020
SN  - 1526-3711
SP  - 718-722
ST  - A Survey on Perceived COVID-19 Risk in Dentistry and the Possible Use of Rapid Tests
T2  - journal of contemporary dental practice
TI  - A Survey on Perceived COVID-19 Risk in Dentistry and the Possible Use of Rapid Tests
VL  - 21
ID  - 7785026
ER  - 

TY  - JOUR
AB  - Pulpitis, inflammation of the dental pulp, is a disease that often necessitates emergency dental care. While pulpitis is considered to be a microbial disease primarily caused by bacteria, viruses have also been implicated in its pathogenesis. Here, we determined the expression of the SARS-CoV2 receptor, angiotensin converting enzyme 2 (ACE2) and its associated cellular serine protease TPMRSS2 in the dental pulp under normal and inflamed conditions. Next, we explored the relationship between the SARS-CoV-2/human interactome and genes expressed in pulpitis. Using existing datasets we show that both ACE2 and TPMRSS2 are expressed in the dental pulp and, that their expression does not change under conditions of inflammation. Furthermore, Master Regulator Analysis of the SARS-CoV2/human interactome identified 75 relevant genes whose expression values are either up-regulated or down-regulated in both the human interactome and pulpitis. Our results suggest that the dental pulp is vulnerable to SARS-CoV2 infection and that SARS-CoV-2 infection of the dental pulp may contribute to worse outcomes of pulpitis.
AD  - Department of Endodontics, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, CA, 94103, USA.
Department of Surgical and Medical Sciences, Magna Graecia University, Campus S. Venuta, Catanzaro, 88100, Italy.
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, 40126, Italy.
Department of Endodontics, School of Dentistry, University of Texas Health and Sciences Center, San Antonio, TX, 78229, USA. khana2@uthscsa.edu.
AN  - 33011745
AU  - Galicia, J. C.
AU  - Guzzi, P. H.
AU  - Giorgi, F. M.
AU  - Khan, A. A.
C1  - 10/6/2020
C2  - PMC7532735
DA  - Oct 3
DB  - PubMed
DO  - 10.1038/s41435-020-00112-6
DP  - NLM
ET  - 2020/10/05
J2  - Genes and immunity
LA  - eng
N1  - 1476-5470
Galicia, Johnah C
Orcid: 0000-0003-1908-5801
Guzzi, Pietro H
Giorgi, Federico M
Khan, Asma A
Orcid: 0000-0002-1389-1434
T90DE021986/U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (NIDCR)/
Journal Article
Genes Immun. 2020 Oct 3:1-4. doi: 10.1038/s41435-020-00112-6.
PY  - 2020
SN  - 1466-4879 (Print)
1466-4879
SP  - 1-4
ST  - Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis
T2  - Genes and immunity
TI  - Predicting the response of the dental pulp to SARS-CoV2 infection: a transcriptome-wide effect cross-analysis
ID  - 7785656
ER  - 

TY  - JOUR
AB  - This study aimed to determine the prevalence of and associations between anxiety, social isolation, and loneliness in a sample of older adults in Northern California during the stay-at-home order enacted during the COVID-19 pandemic. 514 older adults completed a 24-item survey. Perceived isolation and loneliness were reported in 56.4% and 36.0% of participants, respectively. Loneliness was found to be associated with both social isolation and COVID-19-related anxiety; however, social isolation and coronavirus-related anxiety were unrelated. Healthcare providers, social service providers, and families are encouraged to maintain or increase contact with older adults during the COVID-19 pandemic.
AD  - Assistant Professor, Department of Communication Sciences and Disorders, College of Health and Human Services, California State University, Sacramento , Sacramento, California, USA.
Principal Statistician, West Coast Metabolomics Center, University of California , Davis, California, USA.
AN  - 33016253
AU  - Gaeta, L.
AU  - Brydges, C. R.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1080/08959420.2020.1824541
DP  - NLM
ET  - 2020/10/06
J2  - Journal of aging & social policy
KW  - Coronavirus
anxiety
social distancing
LA  - eng
N1  - 1545-0821
Gaeta, Laura
Orcid: 0000-0001-5493-9636
Brydges, Christopher R
Journal Article
England
J Aging Soc Policy. 2020 Oct 4:1-12. doi: 10.1080/08959420.2020.1824541.
PY  - 2020
SN  - 0895-9420
SP  - 1-12
ST  - Coronavirus-Related Anxiety, Social Isolation, and Loneliness in Older Adults in Northern California during the Stay-at-Home Order
T2  - Journal of aging & social policy
TI  - Coronavirus-Related Anxiety, Social Isolation, and Loneliness in Older Adults in Northern California during the Stay-at-Home Order
ID  - 7785210
ER  - 

TY  - JOUR
AU  - Fu, Jun
AU  - Chen, Zhida
AU  - Xu, Xinghua
AU  - Pan, Lichao
AU  - Gu, Liangyou
AU  - Xu, Chi
AU  - Du, Yinqiao
AU  - Ni, Ming
AU  - Chen, Jiying
AU  - Chai, Wei
AU  - Yu, Qilin
AU  - Lu, Qiang
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - COVID-19, SARS-CoV-2, Computed tomography (CT), selective surgery
PY  - 2020
ST  - Was Lung Computed Tomography Necessary for Patients Receiving Selective Surgery from Low-Risk Areas of COVID-19? (preprint)
T2  - SSRN
TI  - Was Lung Computed Tomography Necessary for Patients Receiving Selective Surgery from Low-Risk Areas of COVID-19? (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3673212
ID  - 7788900
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To determine the prevalence and associated mortality of well-defined neurologic diagnoses among COVID-19 patients, we prospectively followed hospitalized SARS-Cov-2 positive patients and recorded new neurologic disorders and hospital outcomes. METHODS: We conducted a prospective, multi-center, observational study of consecutive hospitalized adults in the NYC metropolitan area with laboratory-confirmed SARS-CoV-2 infection. The prevalence of new neurologic disorders (as diagnosed by a neurologist) was recorded and in-hospital mortality and discharge disposition were compared between COVID-19 patients with and without neurologic disorders. RESULTS: Of 4,491 COVID-19 patients hospitalized during the study timeframe, 606 (13.5%) developed a new neurologic disorder in a median of 2 days from COVID-19 symptom onset. The most common diagnoses were: toxic/metabolic encephalopathy (6.8%), seizure (1.6%), stroke (1.9%), and hypoxic/ischemic injury (1.4%). No patient had meningitis/encephalitis, or myelopathy/myelitis referable to SARS-CoV-2 infection and 18/18 CSF specimens were RT-PCR negative for SARS-CoV-2. Patients with neurologic disorders were more often older, male, white, hypertensive, diabetic, intubated, and had higher sequential organ failure assessment (SOFA) scores (all P0.05). After adjusting for age, sex, SOFA-scores, intubation, past history, medical complications, medications and comfort-care-status, COVID-19 patients with neurologic disorders had increased risk of in-hospital mortality (Hazard Ratio[HR] 1.38, 95% CI 1.17-1.62, P0.001) and decreased likelihood of discharge home (HR 0.72, 95% CI 0.63-0.85, P0.001). CONCLUSIONS: Neurologic disorders were detected in 13.5% of COVID-19 patients and were associated with increased risk of in-hospital mortality and decreased likelihood of discharge home. Many observed neurologic disorders may be sequelae of severe systemic illness.
AD  - New York University Grossman School of Medicine, New York, NY, USA jennifer.frontera@nyulangone.org.
New York University Grossman School of Medicine, New York, NY, USA.
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
The Ohio State University, Columbus, OH, USA.
Medical University of Innsbruck, Innsbruck, Austria.
The Johns Hopkins University School of Medicine, Baltimore, MD,USA.
University of Utah School of Medicine, Salt Lake City, UT, USA.
University of Cambridge, Cambridge, UK.
AN  - 33020166
AU  - Frontera, J. A.
AU  - Sabadia, S.
AU  - Lalchan, R.
AU  - Fang, T.
AU  - Flusty, B.
AU  - Millar-Vernetti, P.
AU  - Snyder, T.
AU  - Berger, S.
AU  - Yang, D.
AU  - Granger, A.
AU  - Morgan, N.
AU  - Patel, P.
AU  - Gutman, J.
AU  - Melmed, K.
AU  - Agarwal, S.
AU  - Bokhari, M.
AU  - Andino, A.
AU  - Valdes, E.
AU  - Omari, M.
AU  - Kvernland, A.
AU  - Lillemoe, K.
AU  - Chou, S. H.
AU  - McNett, M.
AU  - Helbok, R.
AU  - Mainali, S.
AU  - Fink, E. L.
AU  - Robertson, C.
AU  - Schober, M.
AU  - Suarez, J. I.
AU  - Ziai, W.
AU  - Menon, D.
AU  - Friedman, D.
AU  - Friedman, D.
AU  - Holmes, M.
AU  - Huang, J.
AU  - Thawani, S.
AU  - Howard, J.
AU  - Abou-Fayssal, N.
AU  - Krieger, P.
AU  - Lewis, A.
AU  - Lord, A. S.
AU  - Zhou, T.
AU  - Kahn, D. E.
AU  - Czeisler, B. M.
AU  - Torres, J.
AU  - Yaghi, S.
AU  - Ishida, K.
AU  - Scher, E.
AU  - de Havenon, A.
AU  - Placantonakis, D.
AU  - Liu, M.
AU  - Wisniewski, T.
AU  - Troxel, A. B.
AU  - Balcer, L.
AU  - Galetta, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1212/wnl.0000000000010979
DP  - NLM
ET  - 2020/10/07
J2  - Neurology
LA  - eng
N1  - 1526-632x
Frontera, Jennifer A
Orcid: 0000-0002-0719-2522
Sabadia, Sakinah
Lalchan, Rebecca
Fang, Taolin
Flusty, Brent
Millar-Vernetti, Patricio
Orcid: 0000-0002-1330-3321
Snyder, Thomas
Berger, Stephen
Yang, Dixon
Granger, Andre
Morgan, Nicole
Patel, Palak
Orcid: 0000-0001-5805-3023
Gutman, Josef
Melmed, Kara
Orcid: 0000-0003-4084-8586
Agarwal, Shashank
Bokhari, Matthew
Andino, Andres
Valdes, Eduard
Orcid: 0000-0002-3532-9194
Omari, Mirza
Kvernland, Alexandra
Lillemoe, Kaitlyn
Chou, Sherry H-Y
Orcid: 0000-0002-5483-2908
McNett, Molly
Helbok, Raimund
Mainali, Shraddha
Orcid: 0000-0002-9495-3843
Fink, Ericka L
Robertson, Courtney
Schober, Michelle
Suarez, Jose I
Ziai, Wendy
Menon, David
Friedman, Daniel
Friedman, David
Holmes, Manisha
Huang, Joshua
Thawani, Sujata
Howard, Jonathan
Abou-Fayssal, Nada
Krieger, Penina
Lewis, Ariane
Lord, Aaron S
Orcid: 0000-0001-8755-7773
Zhou, Ting
Kahn, D Ethan
Czeisler, Barry M
Orcid: 0000-0002-7888-0373
Torres, Jose
Yaghi, Shadi
Ishida, Koto
Scher, Erica
de Havenon, Adam
Placantonakis, Dimitris
Liu, Mengling
Wisniewski, Thomas
Orcid: 0000-0002-3379-8966
Troxel, Andrea B
Balcer, Laura
Galetta, Steven
Journal Article
United States
Neurology. 2020 Oct 5:10.1212/WNL.0000000000010979. doi: 10.1212/WNL.0000000000010979.
PY  - 2020
SN  - 0028-3878
ST  - A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City
T2  - Neurology
TI  - A Prospective Study of Neurologic Disorders in Hospitalized COVID-19 Patients in New York City
ID  - 7785047
ER  - 

TY  - JOUR
AB  - Although there has been increasing focus in recent years on interdisciplinary approaches to health and disease, and in particular the dimension of social inequalities in epidemics, infectious diseases have been much less focused on. This is especially true in the area of cultural dynamics and their effects on pathogen behaviours, although there is evidence to suggest that this relationship is central to shaping our interactions with infectious disease agents on a variety of levels. This paper makes a case for a biocultural approach to pandemics such as COVID-19. It then uses this biocultural framework to examine the anthropogenic dynamics that influenced and continue to shape the COVID-19 pandemic, both during its initial phase and during critical intersections of the pandemic. Through this understanding of biocultural interactions between people, animals and pathogens, a broader societal and political dimension is drawn as a function of population level and international cultures, to reflect on the culturally mediated differential burden of the pandemic. Ultimately, it is argued that a biocultural perspective on infectious disease pandemics will allow for critical reflection on how culture shapes our behaviours at all levels, and how the effects of these behaviours are ultimately foundational to pathogen ecology and evolution.
AD  - Département des sciences humaines et sociales, École des Hautes Études en Santé Publique - Campus de Paris, Saint-Denis, France.
l'Unité des Virus Emergents, Aix-Marseille Université, Marseille, France.
AN  - 33019889
AU  - Friedler, A.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/17441692.2020.1828982
DP  - NLM
ET  - 2020/10/07
J2  - Global public health
KW  - Biocultural
Covid-19
biopolitics
cultural epidemiology
infectious disease
LA  - eng
N1  - 1744-1706
Friedler, Anna
Orcid: 0000-0002-3008-743x
Journal Article
England
Glob Public Health. 2020 Oct 6:1-19. doi: 10.1080/17441692.2020.1828982.
PY  - 2020
SN  - 1744-1692
SP  - 1-19
ST  - Sociocultural, behavioural and political factors shaping the COVID-19 pandemic: the need for a biocultural approach to understanding pandemics and (re)emerging pathogens
T2  - Global public health
TI  - Sociocultural, behavioural and political factors shaping the COVID-19 pandemic: the need for a biocultural approach to understanding pandemics and (re)emerging pathogens
ID  - 7785076
ER  - 

TY  - JOUR
AB  - OBJECTIVES: Several reports had observed a high risk of pulmonary embolism (PE) in patients with coronavirus disease 2019 (COVID-19), most of them in the intensive care unit. Reported findings indicate that a direct viral-mediated hyperinflammatory response leads to local thromboinflammation. According to those findings, the incidence of deep venous thrombosis (DVT) in patients with COVID-19 and PE should be low. The objective of this study was to evaluate the incidence of DVT in patients with COVID-19 who developed PE. METHODS: In this prospective observational study, consecutive patients hospitalized in the internal medicine ward with a diagnosis of COVID-19 who developed PE were screened for DVT in the lower extremities with complete compression ultrasound. RESULTS: The study comprised 26 patients. Fifteen patients (57.7%) were male. The median age was 60 years (interquartile range, 54-73 years). Compression ultrasound findings were positive for DVT in 2 patients (7.7%; 95% confidence interval, 3.6%-11.7%). Patients with DVT had central and bilateral PE. In both, venous thromboembolism was diagnosed in the emergency department, so they did not receive previous prophylactic therapy with low-molecular-weight heparin. Patients without DVT had higher median d-dimer levels: 25,688 μg/dL (interquartile range, 80,000-1210 μg/dL) versus 5310 μg/dL (P �?05). CONCLUSIONS: Our study showed a low incidence of DVT in a cohort of patients with COVID-19 and PE. This observation suggests that PE in these patients could be produced mainly by a local thromboinflammatory syndrome induced by severe acute respiratory syndrome coronavirus 2 infection and not by a thromboembolic event.
AD  - Department of Internal Medicine, Infanta Leonor University Hospital, Madrid, Spain.
Department of Anesthesiology, Infanta Leonor University Hospital, Madrid, Spain.
Department of Radiology, Infanta Leonor University Hospital, Madrid, Spain.
AN  - 33017480
AU  - Franco-Moreno, A.
AU  - Herrera-Morueco, M.
AU  - Mestre-G�Qmez, B.
AU  - Muñoz-Rivas, N.
AU  - Abad-Motos, A.
AU  - Salazar-Chiriboga, D.
AU  - Duffort-Falc�Q, M.
AU  - Medrano-Izquierdo, P.
AU  - Bustamante-Fermosel, A.
AU  - Pardo-Guimera, V.
AU  - Ulla-Anés, M.
AU  - Torres-Macho, J.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/jum.15524
DP  - NLM
ET  - 2020/10/06
J2  - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
KW  - Covid-19
compression ultrasound
coronavirus disease 2019
deep venous thrombosis
pulmonary embolism
thromboinflammatory syndrome
LA  - eng
N1  - 1550-9613
Franco-Moreno, Anabel
Orcid: 0000-0003-1061-0200
Herrera-Morueco, Maria
Mestre-G�Qmez, Beatriz
Muñoz-Rivas, Nuria
Abad-Motos, Ane
Salazar-Chiriboga, Danilo
Duffort-Falc�Q, Mercedes
Medrano-Izquierdo, Pilar
Bustamante-Fermosel, Ana
Pardo-Guimera, Virginia
Ulla-Anés, Mariano
Torres-Macho, Juan
Infanta Leonor Thrombosis Research Group
Journal Article
England
J Ultrasound Med. 2020 Oct 5. doi: 10.1002/jum.15524.
PY  - 2020
SN  - 0278-4297
ST  - Incidence of Deep Venous Thrombosis in Patients With COVID-19 and Pulmonary Embolism: Compression Ultrasound COVID Study
T2  - Journal of ultrasound in medicine : official journal of American Institute of Ultrasound in Medicine
TI  - Incidence of Deep Venous Thrombosis in Patients With COVID-19 and Pulmonary Embolism: Compression Ultrasound COVID Study
ID  - 7785130
ER  - 

TY  - JOUR
AU  - Foss, Nicolai J.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The impact of The Covid-19 pandemic on firms�?organizational designs
T2  - Journal of Management Studies
TI  - The impact of The Covid-19 pandemic on firms�?organizational designs
UR  - https://doi.org/10.1111/joms.12643
ID  - 7788290
ER  - 

TY  - JOUR
AD  - Hygiene and Public Health Unit, Department of Cardiac Thoracic and Vascular Sciences and Public Health, University of Padua , Padova, Italy.
AN  - 33012277
AU  - Fonzo, M.
AU  - Bertoncello, C.
AU  - Baldo, V.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1080/20477724.2020.1827617
DP  - NLM
ET  - 2020/10/06
J2  - Pathogens and global health
KW  - Ifr
Seroprevalence SARS-CoV-2
infection fatality ratio
LA  - eng
N1  - 2047-7732
Fonzo, Marco
Orcid: 0000-0002-9561-0711
Bertoncello, Chiara
Orcid: 0000-0003-4040-8601
Baldo, Vincenzo
Orcid: 0000-0001-6012-9453
Journal Article
England
Pathog Glob Health. 2020 Oct 4:1-2. doi: 10.1080/20477724.2020.1827617.
PY  - 2020
SN  - 2047-7724
SP  - 1-2
ST  - Mortality from COVID-19: are we getting closer to the true value?
T2  - Pathogens and global health
TI  - Mortality from COVID-19: are we getting closer to the true value?
ID  - 7785605
ER  - 

TY  - JOUR
AU  - Foa, Roberto
AU  - Gilbert, Sam
AU  - Fabian, Mark Otto
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Mental health
COVID-19
Coronavirus
Subjective Well-Being
Lockdowns
PY  - 2020
ST  - COVID-19 and Subjective Well-Being: Separating the Effects of Lockdowns from the Pandemic (preprint)
T2  - SSRN
TI  - COVID-19 and Subjective Well-Being: Separating the Effects of Lockdowns from the Pandemic (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3674080
ID  - 7788897
ER  - 

TY  - JOUR
AD  - Haemophilia, Haemostasis & Thrombosis Centre, Hampshire Hospitals NHS Foundation Trust, Basingstoke, UK.
Heamophilia Centre, Great Ormond Street Hospital for Children, London, UK.
Haemophilia Centre, Royal Victoria Infirmary, Newcastle, UK.
Cardiff and Vale UHB, Cardiff, UK.
Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free London NHS Foundation Trust, London, UK.
Belfast Health and Social Care Trust, Belfast, UK.
Leeds Haemophilia Centre, St James' University Hospital, Leeds, UK.
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, UK.
AN  - 33012096
AU  - Flannery, T.
AU  - Bladen, M.
AU  - Hopper, D.
AU  - Jones, S.
AU  - McLaughlin, P.
AU  - Penn, A.
AU  - Sayers, F.
AU  - Wells, A.
AU  - Stephensen, D.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/hae.14166
DP  - NLM
ET  - 2020/10/05
J2  - Haemophilia : the official journal of the World Federation of Hemophilia
LA  - eng
N1  - 1365-2516
Flannery, Thuvia
Orcid: 0000-0002-8196-3241
Bladen, Melanie
Orcid: 0000-0002-7413-1906
Hopper, David
Jones, Sarah
McLaughlin, Paul
Orcid: 0000-0002-5962-7647
Penn, Anne
Sayers, Fionnuala
Orcid: 0000-0001-5119-988x
Wells, Anna
Stephensen, David
Orcid: 0000-0002-6175-3343
Letter
England
Haemophilia. 2020 Oct 4. doi: 10.1111/hae.14166.
PY  - 2020
SN  - 1351-8216
ST  - Physiotherapy after COVID-19-"Zoom or room"
T2  - Haemophilia : official journal of World Federation of Hemophilia
TI  - Physiotherapy after COVID-19-"Zoom or room"
ID  - 7785623
ER  - 

TY  - JOUR
AB  - Protecting the skin of frontline NHS staff suddenly became a priority during the COVID-19 pandemic. This article includes two reflective accounts, one from a critical care sister and another from a tissue viability nurse consultant, both working in acute hospital settings. It details the challenges encountered as staff developed skin damage from wearing personal protective equipment (PPE) and the range of interventions employed to reduce this risk. The importance of learning from this experience and sharing data on a national level is highlighted. © 2020, OmniaMed Communications Ltd. All rights reserved.
AD  - University of Worcester, United Kingdom
Liverpool Heart and Chest NHS Foundation Trust, United Kingdom
AU  - Fisher, P.
AU  - Tyrer, J.
C1  - 10/6/2020
DB  - Scopus
IS  - 3
J2  - Wounds UK
KW  - COVID-19
Masks
Medical-device related skin damage
Personal protective equipment (PPE)
Risk management strategies
Skin damage
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
References: Gefen, A, Ousey, K., Update to device-related pressure ulcers: SECURE prevention. COVID-19, face masks and skin damage (2020) J Wound Care, 29 (5), pp. 245-259. , https://doi.org/10.12968/jowc.2020.29.5.245, (ac-cessed 10 September 2020); (2020) Guidance: New government recommendations for England NHS hospital trusts and private hospital providers, , https://tinyurl.com/yy8b-wwl7, Public Health England Updated 18 June 2020. (accessed 20 July 2020); (2020) Helping prevent facial skin damage beneath personal protective equipment, , https://tinyurl.com/y954gbpq, NHS England, NHS Improvement. (accessed 10 September 2020)
PY  - 2020
SN  - 17466814 (ISSN)
SP  - 56-60
ST  - The challenges of personal protective equipment induced skin damage during covid-19: Two perspectives, one mission
T2  - Wounds UK
TI  - The challenges of personal protective equipment induced skin damage during covid-19: Two perspectives, one mission
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091722795&partnerID=40&md5=20eee142866bbcae1f2fa5c73f168a25
VL  - 16
ID  - 7783290
ER  - 

TY  - JOUR
AB  - INTRODUCTION: In the context of community transmission of the virus, the impact of the pandemic on health-care systems, mainly on intensive care units (ICU), was expected to be devastating. Vall d́Hebron University Hospital (HUVH) implemented an unprecedented critical patient-care planning and management of resources. METHODS: We describe a cohort of critically ill patients during the first two months of the pandemic (from March 3, 2020, to May 2, 2020) in HUVH, Barcelona. In this manuscript, we report our previsions, strategies implemented, and the outcomes obtained. RESULTS: Three-thousand and thirty-three patients were admitted to the HUVH Critical Care Units. Throughout the study period, the proportion of patients on IMV or IMV and ECMO remained above 78%. Most patients were men (65%); the most common age group was 60-70 years. Twenty-three patients received ECMO, and eighteen were cannulated at another center and transferred to HUVH. At the end of the study, fourteen patients were successfully decannulated, three patients died, and the rest of the patients were still on ECMO. Eight pregnant women have been treated in the ICU, with a survival rate of 100%. The ICU mortality of patients younger than 60 years was 3.2%. The mean ICU stay of both survivors and nonsurvivors was 14 days. CONCLUSION: The adequate preparation for resource expansion for critically ill patients care, main challenges, and overall positive results can serve as a precedent for similar future scenarios.
AD  - Servicio de Medicina Intensiva. Hospital Universitario Vall d'Hebron. Sepsis Organ Dysfunction and Resuscitation (SODIR) Research group. Vall d'Hebron Institut de Recerca (VHIR). Universidad Aut�Qnoma de Barcelona (UAB), Barcelona, España. Electronic address: r.ferrer@vhebron.net.
Servicio de Medicina Intensiva. Hospital Universitario de Traumatolog�Ta, Rehabilitaci�Qn y Quemados Vall d'Hebron, Barcelona, España.
Unidad de Cuidados Intensivos Pedi֙tricos. Hospital Universitario Vall d'Hebron. Universidad Aut�Qnoma de Barcelona , Barcelona, España.
Acute Cardiovascular Care Unit, Department of Cardiology, Centre de Simulaci�Q Cl�Tnica Avançada VHISCA, Vall d'Hebron Hospital, Universidad Aut�Qnoma de Barcelona. CIBERCV, Barcelona, España.
Servicio de Anestesiolog�Ta y Reanimaci�Qn. Hospital Universitario Vall d'Hebron, Barcelona, España.
Servicio de Medicina Intensiva. Hospital Universitario Vall d'Hebron. Sepsis Organ Dysfunction and Resuscitation (SODIR) Research group. Vall d'Hebron Institut de Recerca (VHIR). Universidad Aut�Qnoma de Barcelona (UAB), Barcelona, España.
Coordinador de cr�Tticos. Hospital Universitario Vall d'Hebron, Barcelona, España.
AN  - 33010961
AU  - Ferrer, R.
AU  - B֙guena, M.
AU  - Balcells, J.
AU  - Bañeras, J.
AU  - Biarnes, A.
AU  - de Nadal, M.
AU  - Gracia, R. M.
AU  - Martinez, J.
AU  - Nuvials, X.
AU  - Riera, J.
AU  - Roca, O.
AU  - Ruiz-Rodriguez, J. C.
C1  - 10/6/2020
DA  - Sep 8
DB  - PubMed
DO  - 10.1016/j.eimc.2020.08.007
DP  - NLM
ET  - 2020/10/05
J2  - Enfermedades infecciosas y microbiologia clinica
KW  - Acute respiratory distress syndrome
Covid-19
Coronavirus
Distrés respiratorio
Health-care system
Hospital resources
Icu
Recursos hospitalarios
Sistema sanitario
Uci
LA  - eng
spa
N1  - 1578-1852
Ferrer, Ricard
B֙guena, Marcelino
Balcells, Joan
Bañeras, Jordi
Biarnes, Alfons
de Nadal, Miriam
Gracia, Rosa Mar�Ta
Martinez, Jesús
Nuvials, Xavier
Riera, Jordi
Roca, Oriol
Ruiz-Rodriguez, Juan Carlos
Journal Article
Spain
Enferm Infecc Microbiol Clin. 2020 Sep 8:S0213-005X(20)30272-X. doi: 10.1016/j.eimc.2020.08.007.
OP  - Organizaci�Qn de la atenci�Qn a pacientes cr�Tticos en situaci�Qn de pandemia: Experiencia del Hospital Vall d’Hebron durante el brote de neumon�Ta por SARS-CoV-2.
PY  - 2020
SN  - 0213-005x
ST  - Planning for the assistance of critically ill patients in a Pandemic Situation: The experience of Vall d'Hebron University Hospital
T2  - Enfermedades infecciosas y microbiologia clinica
TI  - Planning for the assistance of critically ill patients in a Pandemic Situation: The experience of Vall d'Hebron University Hospital
ID  - 7785707
ER  - 

TY  - JOUR
AB  - Coronavirus Disease 2019 (COVID-19) is a pandemic infection caused by a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients present a complex clinical picture that, in severe cases, evolves to respiratory, hepatic, gastrointestinal, and neurological complications, and eventually death. The underlying pathophysiological mechanisms are complex and multifactorial and have been summarized as a hyperresponse of the immune system that originates an inflammatory/cytokine storm. In elderly patients, particularly in those with pre-existing cardiovascular, metabolic, renal, and pulmonary disorders, the disease is particularly severe, causing prolonged hospitalization at intensive care units (ICU) and an increased mortality rate. Curiously, the same populations have been described as more prone to a gut microbiota (GM) dysbiosis profile. Intestinal microflora plays a major role in many metabolic and immune functions of the host, including to educate and strengthen the immune system to fight infections, namely of viral origin. Notably, recent studies suggest the existence of GM dysbiosis in COVID-19 patients. This review article highlights the interplay between the triad GM dysbiosis-immune hyperresponse-inflammation in the individual resilience/fragility to SARS-CoV-2 infection and presents the putative impact of pharmacological and nutraceutical approaches on the triumvirate, with focus on GM.
AD  - Institute of Pharmacology & Experimental Therapeutics, Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.
Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, 3004-504 Coimbra, Portugal.
Clinical Academic Center of Coimbra (CACC), 3000-075 Coimbra, Portugal.
Polytechnic Institute of Coimbra, ESTESC-Coimbra Health School, Pharmacy, 3046-854 Coimbra, Portugal.
AN  - 33019592
AU  - Ferreira, C.
AU  - Viana, S. D.
AU  - Reis, F.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/microorganisms8101514
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Microorganisms
KW  - Covid-19
SARS-CoV-2 infection
gut microbiota dysbiosis
immune hyperresponse
inflammation
pharmacological and nutraceutical approaches
LA  - eng
N1  - Ferreira, Carolina
Orcid: 0000-0002-4074-9513
Viana, Sofia D
Reis, Fl֙vio
Orcid: 0000-0003-3401-9554
This work was supported by the European Regional Development Fund (FEDER), through Programa Operacional Factores de Competitividade COMPETE2020 (CENTRO-01-0145-FEDER-000012-HealthyAging2020) and by National funds via Portuguese Science and Technology Foun/Fundação para a Ci�^ncia e a Tecnologia/
Journal Article
Review
Switzerland
Microorganisms. 2020 Oct 1;8(10):E1514. doi: 10.3390/microorganisms8101514.
PY  - 2020
SN  - 2076-2607 (Print)
2076-2607
ST  - Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches
T2  - Microorganisms
TI  - Gut Microbiota Dysbiosis-Immune Hyperresponse-Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches
VL  - 8
ID  - 7785095
ER  - 

TY  - JOUR
AB  - Since the COVID-19 outbreak, researchers have tried to characterise the novel coronavirus SARS-CoV-2 to better understand the pathogenic mechanisms of the virus and prevent further dissemination. As a consequence, there has been a bloom in scientific research papers focused on the behaviour of the virus in different environmental contexts. Nevertheless, despite these efforts and due to its novelty, available information about this coronavirus is limited, as several research studies are still ongoing. This review aims to shed light on this issue. To that end, we have examined the scientific literature to date regarding the viability of SARS-CoV-2 on surfaces and fluids or under different environmental conditions (temperature, precipitation and UV radiation). We have also addressed the role of animals in the transmission of this coronavirus.
AD  - IMARENAB, Applied Chemical and Physics Department, University of Le�Qn, Spain; Celera talent association, Madrid, Spain. Electronic address: maria.raga@unileon.es.
Celera talent association, Madrid, Spain.
Celera talent association, Madrid, Spain; Prospera Biotech. Scientific Park Universitas Miguel Hern֙ndez, Elche, Spain.
Celera talent association, Madrid, Spain; Xplore.ai, Madrid, Spain.
Celera talent association, Madrid, Spain; Data Team, Savana Medica, Madrid, Spain.
AN  - 33017611
AU  - Fern֙ndez-Raga, M.
AU  - D�Taz-Marug֙n, L.
AU  - Garc�Ta, M.
AU  - Bort, C.
AU  - Fanjul, V.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.envres.2020.110293
DP  - NLM
ET  - 2020/10/06
J2  - Environmental research
KW  - Covid-19
SARS-CoV-2
UV radiation
animal-transmission
surfaces
temperature
viability
of interest. The authors declare that they have no known competing financial
interests or personal relationships that could have appeared to influence the work
reported in this paper.
LA  - eng
N1  - 1096-0953
Fern֙ndez-Raga, Mar�Ta
D�Taz-Marug֙n, Laura
Garc�Ta, Marta
Bort, Carlos
Fanjul, V�Tctor
Journal Article
Review
Netherlands
Environ Res. 2020 Oct 2:110293. doi: 10.1016/j.envres.2020.110293.
PY  - 2020
SN  - 0013-9351
SP  - 110293
ST  - SARS-CoV-2 Viability under Different Meteorological Conditions, Surfaces, Fluids and Transmission between Animals
T2  - Environmental research
TI  - SARS-CoV-2 Viability under Different Meteorological Conditions, Surfaces, Fluids and Transmission between Animals
ID  - 7785126
ER  - 

TY  - JOUR
AB  - The pandemic caused by the new coronavirus (SARS-Cov-2) has encouraged numerous in vitro studies and clinical trials around the world, with research groups testing existing drugs, novel drug candidates and vaccines that can prevent or treat infection caused by this virus. The urgency for an effective therapy is justified by the easy and fast viral transmission and the high number of patients with severe respiratory distress syndrome who have increasingly occupied intensive care hospital beds, leading to a collapse in health systems in several countries. However, to date, there is no sufficient evidence of the effectiveness of any researched therapy. The off-label or compassionate use of some drugs by health professionals is a reality in all continents, whose permission by regulatory agencies has been based on the results of some clinical trials. In order to guide decision-making for the treatment of COVID-19, this review aims to present studies and guidelines on the main therapies that have been and are currently being tested against SARS-CoV-2 and to critically analyze the reported evidences. © Copyright © 2020 Fernandes, Vale, Guzen, Pinheiro, Cobucci and de Azevedo.
AD  - (Fernandes) Nurse Department, Nurse School, Universidade do Estado do Rio Grande do Norte (UERN), Mossoro, Brazil (Vale) Tocogynecology Department, Medical School, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Brazil (Vale, Guzen, Pinheiro, Cobucci, de Azevedo) Graduate Program of Biotechnology, Laureate International Universities - Universidade Potiguar (UnP), Natal, Brazil (Pinheiro, Cobucci) Medical School, Laureate International Universities - Universidade Potiguar (UnP), Natal, Brazil
E.P. de Azevedo, Graduate Program of Biotechnology, Laureate International Universities - Universidade Potiguar (UnP), Natal, Brazil. E-mail: eduardo.azevedo@unp.br
AN  - 632973798
AU  - Fernandes, A. C. L.
AU  - Vale, A. J. M.
AU  - Guzen, F. P.
AU  - Pinheiro, F. I.
AU  - Cobucci, R. N.
AU  - de Azevedo, E. P.
C1  - 10/6/2020
DA  - 15 Sep
DB  - Embase
DO  - http://dx.doi.org/10.3389/fmed.2020.00546
DP  - Ovid Technologies
IS  - 546
KW  - coronavirus
covid-19
drug treatment
prophylaxis
SARS-CoV-2
viral infection
compassionate use
coronavirus disease 2019
decision making
human
practice guideline
review
LA  - English
M3  - Review
PY  - 2020
SN  - 2296-858X (electronic)
2296-858X
ST  - Therapeutic Options Against the New Coronavirus: Updated Clinical and Laboratory Evidences
T2  - Frontiers in Medicine
TI  - Therapeutic Options Against the New Coronavirus: Updated Clinical and Laboratory Evidences
UR  - http://journal.frontiersin.org/journal/medicine
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632973798
VL  - 7 (no pagination)
ID  - 7782917
ER  - 

TY  - JOUR
AB  - In the context of COVID-19, many companies have been affected by the financial crisis In order to carry out a comparative study on the accuracy of the company&#039;s financial crisis early warning method, this study used RPROP artificial neural network and support vector machine, with 162 listed companies&#039; two-year panel financial indicator data as a model sample, and the test sample established a financial crisis early warning model The theory of comprehensive evaluation combining two kinds of neural network methods is put forward innovatively The predicted results can strengthen the supervision of the listed companies with risks by themselves and others and have important economic and social significance to ensure the stable operation of the listed companies, the securities market, and the national economy
AU  - Feixiong, Ma
AU  - Yingying, Zhou
AU  - Xiaoyan, Mo
AU  - Yiwei, Xia
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - The Establishment of a Financial Crisis Early Warning System for Domestic Listed Companies Based on Two Neural Network Models in the Context of COVID-19
T2  - Mathematical Problems in Engineering
TI  - The Establishment of a Financial Crisis Early Warning System for Domestic Listed Companies Based on Two Neural Network Models in the Context of COVID-19
UR  - https://doi.org/10.1155/2020/5045207
ID  - 7788320
ER  - 

TY  - JOUR
AB  - Viruses can induce autoimmune diseases, in addition to genetic predisposition and environmental factors. Particularly, coronaviruses are mentioned among the viruses implicated in autoimmunity. Today, the world's greatest threat derives from the pandemic of a new human coronavirus, called "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2), the responsible agent of coronavirus disease 2019 (COVID-19). COVID-19 originated in Wuhan, the capital of Hubei, China in December 2019 and, to date, has spread to at least 187 countries. This review focuses on autoimmune manifestations described during COVID-19, including pro-thrombothic state associated to antiphospholipid antibodies (aPL), acute interstitial pneumonia, macrophage activation syndrome, lymphocytopenia, systemic vasculitis, and autoimmune skin lesions. This offers the opportunity to highlight the pathogenetic mechanisms common to COVID19 and several autoimmune diseases, in order to identify new therapeutic targets. In a supposed preliminary pathogenetic model, SARS-CoV-2 plays a direct role in triggering widespread microthrombosis and microvascular inflammation, because it is able to induce transient aPL, endothelial damage and complement activation at the same time. Hence, endothelium might represent the common pathway in which autoimmunity and infection converge. In addition, autoimmune phenomena in COVID-19 can be explained by regulatory T cells impairment and cytokines cascade.
AD  - Internal Medicine surgery, PTA Trani, ASL Barletta-Andria-Trani. Italy.
AN  - 33019935
AU  - Fatone, M. C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.2174/1573397116666201005122603
DP  - NLM
ET  - 2020/10/07
J2  - Current rheumatology reviews
KW  - Covid-19
antiphospholipid antibodies
autoimmune manifestations
endothelium
pathogenesis
regulatory T cells
thrombosis
vasculitis.
LA  - eng
N1  - 1875-6360
Fatone, Maria Celeste
Journal Article
United Arab Emirates
Curr Rheumatol Rev. 2020 Oct 5. doi: 10.2174/1573397116666201005122603.
PY  - 2020
SN  - 1573-3971
ST  - COVID-19: a Great Mime or a Trigger Event of Autoimmune Manifestations?
T2  - Current rheumatology reviews
TI  - COVID-19: a Great Mime or a Trigger Event of Autoimmune Manifestations?
ID  - 7785070
ER  - 

TY  - JOUR
AB  - In the hospital department dedicated to COVID-19-patient, infection prevention and control measures were upgraded. Therefore, the cross-transmission of other micro-organisms was thought unlikely to occur. However, we report an outbreak of NDM-5-producing E. coli in a 12-beds ICU dedicated to COVID-19 patients. This outbreak involved 6 patients of which 5 were asymptomatic carriers and 1 was infected. Several findings might have contributed to cross-transmission including the multiple-bedroom configuration of the department, uncomplete compliance for standard and contact precautions, overwork due to the burden of the disease, lack of training of staff for the care of ICU-patients, and misuse of gloves. Furthermore, as infection prevention and control measures were thought to be the applied, contact patients were not screened for eXDR carriage. Applying rigorously standard and contact precautions and performing screening in contact patients when indicated must be the rules in COVID-19 wards.
AD  - Service de biologie Clinique, Hôpital Foch, Suresnes, France. Electronic address: e.farfour@hopital-foch.org.
Service de biologie Clinique, Hôpital Foch, Suresnes, France.
Service des microbiologie, Centre National de Référence de la résistance aux antibiotiques, Hôpital Bic�^tre, Le Kremlin-Bic�^tre, France.
Service d'anesthésie-réanimation, Hôpital Foch, Suresnes, France.
Service de réanimation polyvalente, Hôpital Foch, Suresnes, France.
AN  - 33011336
AU  - Farfour, E.
AU  - Lecuru, M.
AU  - Dortet, L.
AU  - Guen, M. L.
AU  - Cerf, C.
AU  - Karnycheff, F.
AU  - Bonnin, R. A.
AU  - Vasse, M.
AU  - Lesprit, P.
C1  - 10/6/2020
C2  - PMC7529666
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.ajic.2020.09.015
DP  - NLM
ET  - 2020/10/05
J2  - American journal of infection control
KW  - Covid-19
CPE (carbapenemase-producing Enterobacterales)
Intervention and prevention control (IPC)
SARS-CoV-2
eXDR
outbreak
pandemic
LA  - eng
N1  - 1527-3296
Farfour, Eric
Lecuru, Marion
Dortet, Laurent
Guen, Morgan Le
Cerf, Charles
Karnycheff, Françoise
Bonnin, Rémy A
Vasse, Marc
Lesprit, Philippe
SARS-CoV-2 Hospital Foch study group
Journal Article
Am J Infect Control. 2020 Oct 1:S0196-6553(20)30895-6. doi: 10.1016/j.ajic.2020.09.015.
PY  - 2020
SN  - 0196-6553 (Print)
0196-6553
ST  - Carbapenemase-producing Enterobacterales outbreak: another dark side of COVID-19
T2  - American journal of infection control
TI  - Carbapenemase-producing Enterobacterales outbreak: another dark side of COVID-19
ID  - 7785676
ER  - 

TY  - JOUR
AD  - Department of Haematology, Tan Tock Seng Hospital, Singapore, Singapore; Department of Laboratory Medicine, Khoo Teck Puat Hospital, Singapore, Singapore; Lee Kong Chian School of Medicine, Singapore, Singapore; Yong Loo Lin School of Medicine, Singapore, Singapore. Electronic address: Bingwen_Eugene_Fan@ttsh.com.sg.
AN  - 33011045
AU  - Fan, B. E.
C1  - 10/6/2020
C2  - PMC7505648
DA  - Sep 21
DB  - PubMed
DO  - 10.1016/j.acra.2020.09.005
DP  - NLM
ET  - 2020/10/05
J2  - Academic radiology
LA  - eng
N1  - 1878-4046
Fan, Bingwen Eugene
Letter
Acad Radiol. 2020 Sep 21:S1076-6332(20)30544-4. doi: 10.1016/j.acra.2020.09.005.
PY  - 2020
SN  - 1076-6332 (Print)
1076-6332
ST  - COVID-19-Associated Thromboembolic Events Causing Acute Mesenteric Ischaemia
T2  - Academic radiology
TI  - COVID-19-Associated Thromboembolic Events Causing Acute Mesenteric Ischaemia
ID  - 7785699
ER  - 

TY  - JOUR
AB  - Australians have been facing many psychological and behavioural challenges since the start of the COVID-19 pandemic. While the number of studies are limited, some research suggests that the psychological effects of quarantine are long-lasting and can still be detected months or years later. The following article presents the latest research about prosocial behaviour and meditation to assist health practitioners in clinical practice navigate the uncertainty of the coming 'post-quarantine' period. Copyright © NHAA 2020.
AD  - (Fahey) Vital.ly P/L, Australia
J. Fahey, vital.ly, Unit 1, 597 Gardeners Road, Mascot, NSW 2020, Australia. E-mail: jacqui@vital.ly
AN  - 2005146162
AU  - Fahey, J.
C1  - 10/6/2020
DA  - June
DB  - Embase
DO  - http://dx.doi.org/10.33235/ajhnm.32.2.62-64
DP  - Ovid Technologies
IS  - 2
KW  - covid-19
Healthcare practitioner
Meditation
Mental health
Australian
clinical practice
coronavirus disease 2019
health care personnel
human
note
pandemic
quarantine
uncertainty
LA  - English
M3  - Note
PY  - 2020
SN  - 2209-119X
2209-1203
SP  - 62-64
ST  - Balancing the psychological impacts of covid-19
T2  - Australian Journal of Herbal and Naturopathic Medicine
TI  - Balancing the psychological impacts of covid-19
UR  - https://www.nhaa.org.au/publications/australian-journal-of-herbal-medicine
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005146162
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.33235%2Fajhnm.32.2.62-64&issn=2209-119X&isbn=&volume=32&issue=2&spage=62&pages=62-64&date=2020&title=Australian+Journal+of+Herbal+and+Naturopathic+Medicine&atitle=Balancing+the+psychological+impacts+of+covid-19&aulast=Fahey&pid=%3Cauthor%3EFahey+J.%3C%2Fauthor%3E&%3CAN%3E2005146162%3C%2FAN%3E&%3CDT%3ENote%3C%2FDT%3E
VL  - 32
ID  - 7783003
ER  - 

TY  - JOUR
AB  - While studies have explored how health sector corruption, weak healthcare system, large-scale immune compromised population, misinformation and prevalence of highly congested slums contribute to the spread of COVID-19 in Nigeria, they have glossed over the impact of political distrust on the spread of the virus. This study explores the impact of political distrust on the spread of COVID-19 pandemic in Nigeria. The study utilised qualitative dominant mixed methods approach comprising telephone interviews and a survey of 120 educated Nigerians purposively selected from four COVID-19 most affected states including Lagos, Oyo, Kano and Rivers as well as the Federal Capital Territory, Abuja. The study also relied on secondary data on the spread of COVID-19 in Nigeria sourced from Nigeria Centre for Diseases Control from 27 February to 31st August 2020. The study found that political corruption motivates large-scale political distrust. This undermines public compliance to government protocols, limits the outcomes of government responses to COVID-19 and facilitates the spread of the virus in Nigeria. The paper concludes that improving government accountability in the public sector management is relevant for building public trust, promoting citizens' compliance to COVID-19 safety measure and mitigating the spread of the pandemic in Nigeria and beyond.
AD  - Department of Political Science University of Nigeria, Nsukka, Nigeria.
Population Studies and Social Policy Research Group, University of Nigeria, Nsukka, Nigeria.
Department of Surgery, University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu, Nigeria.
Department of Pharmaceutical Microbiology and Biotechnology, University of Nigeria, Nsukka, Nigeria.
Department of Public Administration, University of Nigeria, Nsukka, Nigeria.
Department of Philosophy, University of Nigeria, Nsukka, Nigeria.
Department of Geography, University of Nigeria, Nsukka, Nigeria.
Department of Sociology and Anthropology, University of Nigeria, Nsukka, Nigeria.
AN  - 33019916
AU  - Ezeibe, C. C.
AU  - Ilo, C.
AU  - Ezeibe, E. N.
AU  - Oguonu, C. N.
AU  - Nwankwo, N. A.
AU  - Ajaero, C. K.
AU  - Oasadebe, N.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1080/17441692.2020.1828987
DP  - NLM
ET  - 2020/10/07
J2  - Global public health
KW  - Political distrust
government response
health sector crisis
political corruption
spread of COVID-19
LA  - eng
N1  - 1744-1706
Ezeibe, Christian C
Orcid: 0000-0003-4465-4076
Ilo, Chukwudi
Ezeibe, Ezinwanne N
Oguonu, Chika N
Nwankwo, Nnamdi A
Ajaero, Chukwuedozie K
Orcid: 0000-0002-6658-3638
Oasadebe, Nnabuike
Journal Article
England
Glob Public Health. 2020 Oct 6:1-14. doi: 10.1080/17441692.2020.1828987.
PY  - 2020
SN  - 1744-1692
SP  - 1-14
ST  - Political distrust and the spread of COVID-19 in Nigeria
T2  - Global public health
TI  - Political distrust and the spread of COVID-19 in Nigeria
ID  - 7785073
ER  - 

TY  - JOUR
AD  - Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America. Electronic address: laura.even@cchmc.org.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America; Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America. Electronic address: matthew.lipshaw@cchmc.org.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America; Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America. Electronic address: paria.wilson@cchmc.org.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America. Electronic address: preston.dean@cchmc.org.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America; Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America. Electronic address: benjamin.kerrey@cchmc.org.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States of America; Division of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States of America. Electronic address: adam.vukovic@cchmc.org.
AN  - 33010994
AU  - Even, L.
AU  - Lipshaw, M. J.
AU  - Wilson, P. M.
AU  - Dean, P.
AU  - Kerrey, B. T.
AU  - Vukovic, A. A.
C1  - 10/6/2020
DA  - Sep 28
DB  - PubMed
DO  - 10.1016/j.ajem.2020.09.074
DP  - NLM
ET  - 2020/10/05
J2  - The American journal of emergency medicine
KW  - Covid-19
Length of stay
Patient flow
Pediatric emergency medicine
conflict of interest. PMW reports no conflict of interest. PD reports no conflict of
interest. AAV reports no conflict of interest.
LA  - eng
N1  - 1532-8171
Even, Laura
Lipshaw, Matthew J
Wilson, Paria M
Dean, Preston
Kerrey, Benjamin T
Vukovic, Adam A
Letter
United States
Am J Emerg Med. 2020 Sep 28:S0735-6757(20)30870-6. doi: 10.1016/j.ajem.2020.09.074.
PY  - 2020
SN  - 0735-6757
ST  - Pediatric emergency department volumes and throughput during the COVID-19 pandemic
T2  - American journal of emergency medicine
TI  - Pediatric emergency department volumes and throughput during the COVID-19 pandemic
ID  - 7785705
ER  - 

TY  - JOUR
AB  - COVID-19 has wreaked havoc globally with particular concerns for sub-Saharan Africa (SSA), where models suggest that the majority of the population will become infected. Conventional wisdom suggests that the continent will bear a higher burden of COVID-19 for the same reasons it suffers from other infectious diseases: ecology, socio-economic conditions, lack of water and sanitation infrastructure, and weak health systems. However, so far SSA has reported lower incidence and fatalities compared to the predictions of standard models and the experience of other regions of the world. There are three leading explanations, each with different implications for the final epidemic burden: (1) low case detection, (2) differences in epidemiology (e.g. low R (0) ), and (3) policy interventions. The low number of cases have led some SSA governments to relaxing these policy interventions. Will this result in a resurgence of cases? To understand how to interpret the lower-than-expected COVID-19 case data in Madagascar, we use a simple age-structured model to explore each of these explanations and predict the epidemic impact associated with them. We show that the incidence of COVID-19 cases as of July 2020 can be explained by any combination of the late introduction of first imported cases, early implementation of non-pharmaceutical interventions (NPIs), and low case detection rates. We then re-evaluate these findings in the context of the COVID-19 epidemic in Madagascar through August 2020. This analysis reinforces that Madagascar, along with other countries in SSA, remains at risk of a growing health crisis. If NPIs remain enforced, up to 50,000 lives may be saved. Even with NPIs, without vaccines and new therapies, COVID-19 could infect up to 30% of the population, making it the largest public health threat in Madagascar for the coming year, hence the importance of clinical trials and continually improving access to healthcare.
AD  - Odum School of Ecology and Center for the Ecology of Infectious Diseases, University of Georgia , Athens, GA, USA.
MIVEGEC, Ecole Pierre Louis de Santé Publique, Université de Montpellier, CNRS, IRD , Montpellier, France.
PIVOT , Ranomafana, Madagascar.
Madagascar Institut pour la Conservation des Ecosyst؈mes Tropicaux , Antananarivo, Madagascar.
Sorbonne Universite , Paris, France.
Department of Mathematics and Emerging Pathogens Institute, University of Florida , Gainesville, FL, USA.
IRD, Sorbonne Université, UMMISCO , Bondy, France.
Universidad Nacional Aut�Qnoma de México , Ciudad de México, México.
Harvard Medical School , Boston, MA, USA.
Faculty of Medicine, University of Antananarivo , Antananarivo, Madagascar.
AN  - 33012269
AU  - Evans, M. V.
AU  - Garchitorena, A.
AU  - Rakotonanahary, R. J. L.
AU  - Drake, J. M.
AU  - Andriamihaja, B.
AU  - Rajaonarifara, E.
AU  - Ngonghala, C. N.
AU  - Roche, B.
AU  - Bonds, M. H.
AU  - Rakotonirina, J.
C1  - 10/6/2020
DA  - Dec 31
DB  - PubMed
DO  - 10.1080/16549716.2020.1816044
DP  - NLM
ET  - 2020/10/06
IS  - 1
J2  - Global health action
KW  - Covid-19
Madagascar
age-structured contacts
infectious disease modelling
non-pharmaceutical interventions
outbreak response
LA  - eng
N1  - 1654-9880
Evans, Michelle V
Orcid: 0000-0002-5628-0502
Garchitorena, Andres
Rakotonanahary, Rado J L
Drake, John M
Andriamihaja, Benjamin
Rajaonarifara, Elinambinina
Ngonghala, Calistus N
Roche, Benjamin
Bonds, Matthew H
Rakotonirina, Julio
Journal Article
United States
Glob Health Action. 2020 Dec 31;13(1):1816044. doi: 10.1080/16549716.2020.1816044.
PY  - 2020
SN  - 1654-9880
SP  - 1816044
ST  - Reconciling model predictions with low reported cases of COVID-19 in Sub-Saharan Africa: insights from Madagascar
T2  - Global health action
TI  - Reconciling model predictions with low reported cases of COVID-19 in Sub-Saharan Africa: insights from Madagascar
VL  - 13
ID  - 7785609
ER  - 

TY  - JOUR
AB  - On September 22nd the US officially recorded 200,000 COVID-19 deaths. It is unclear how many deaths might have been expected in the case of an early and effective response to the pandemic. We aim to provide a best-case estimate of COVID-19 deaths in the US by September 22nd using the experience of Germany as a benchmark. Our methods accommodate the differences in demographics between Germany and the US. We match cumulative incidence of COVID-19 deaths by age group in Germany to non-Hispanic whites in the US and project the implied number of deaths in this population and among the black and Hispanic populations under observed racial/ethnic disparities in cumulative COVID-19 mortality in the US. We estimate that if the US had been as successful as Germany in managing the pandemic we would have expected 22% of the deaths actually recorded. The number of deaths would have been lower by a further one-third if we could have eliminated racial/ethnic disparities in COVID-19 outcomes. We conclude that almost 80 percent of the COVID-19 deaths in the US by September 22nd could have been avoided with an early and effective response producing similar age-specific death rates among non-Hispanic whites as in Germany.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis project was not funded by any specific mechanismAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:N/AAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data is publicly available. German death rates are from the Robert Koch Institute. US population and deaths by race/ethnicity are from the CDC.https://www.rki.de/EN/Content/infections/epidemiology/outbreaks/COVID-19/COVID19.htmlhttps://data.cdc.gov/NCHS/Deaths-involving-coronavirus-disease-2019-COVID-19/ks3g-spdg
AU  - Etzioni, Ruth
AU  - Markowitz, Elan
AU  - Douglas, Ivor S.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.09.30.20204586
DP  - medRxiv
PY  - 2020
SP  - 2020.09.30.20204586
ST  - Benchmarking COVID-19 Mortality in the United States (preprint)
T2  - medRxiv
TI  - Benchmarking COVID-19 Mortality in the United States (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.09.30.20204586.abstract
ID  - 7788884
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic has caused significant disruption in the lives of millions of people, including children and adolescents Youth out-of-school time (OST) programs are essential ecological assets and their disruption during the pandemic may have a major impact on youth developmental pathways Youth programs are one of the primary ways to promote positive youth development (PYD) and, in turn, develop healthy and thriving young adults who contribute positively to society The pandemic raises the question of how to sustain developmentally oriented forms of youth leisure in times of crisis and, especially, how to support youth with few resources Although there is considerable scientific evidence regarding the promotion of PYD through OST programs (e g , sport, clubs, youth groups), public health initiatives to control the pandemic also curtail the delivery of such programs Nevertheless, research on youth programs can be applied to help support PYD during the pandemic In this commentary, we review key elements contributing to the effectiveness of youth development programs and provide ideas for how to sustain, adapt, and create these elements and bring them into unstructured leisure settings in the face of the pandemic In doing so, we highlight particular challenges to implementation, surmise who may be most at risk, and present potential opportunities afforded by the unique situation Throughout, we highlight innovative examples of adaptation exhibited in affected communities We conclude with a call to action for researchers and practitioners to unite efforts to support PYD through leisure even in the face of crisis
AU  - Ettekal, Andrea Vest
AU  - Agans, Jennifer P.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Positive Youth Development Through Leisure: Confronting the COVID-19 Pandemic
T2  - Journal of Youth Development
TI  - Positive Youth Development Through Leisure: Confronting the COVID-19 Pandemic
UR  - https://doi.org/10.5195/jyd.2020.962
ID  - 7788400
ER  - 

TY  - JOUR
AB  - In the midst of the SARS-CoV-2 public-health pandemic emergency, it is important to understand its zoonotic origin and how an animal virus finally infects humans. Identifying the circumstances in which a virus jumps species boundaries to infect humans so productively is objective of this work and will help us to determine the epidemiology and pathogenisis of this agent. Nowadays, it is known that bats serve as reservoir hosts for virus progenitor, but determine the possibility of a potential intermediate host of SARS-CoV-2 is still a challenge. Scientific investigations stablish the natural selection theory as the most probable (natural selection in an animal host before zoonotic transfer or acquired mutations in humans following crossing species barrier). It is necessary to find out how SARS-CoV-2 emerged, its rapidly spreads within a community and the optimal context in which this virus binds to human receptor. One Health is a multisectoral, collaborative and transdisciplinary approach which allows a cooperative working between animal and human health that will help us to introduce some possible control measures that might reduce the spread of the virus; improving sanitary management, identifying new outbreaks and preventing future zoonotic and pandemic events.
AU  - Estévez Reboredo, Rosa M.
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - es
PY  - 2020
ST  - Teor�Tas del origen del SARS-CoV-2, claves e inc�Qgnitas de una enfermedad emergente
T2  - Revista Española de Salud Pública
TI  - Teor�Tas del origen del SARS-CoV-2, claves e inc�Qgnitas de una enfermedad emergente
TT  - [Origin of SARS-CoV-2 theories, keys and unknowns of an emerged disease.]
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812993
VL  - 94
ID  - 7788460
ER  - 

TY  - JOUR
AB  - Coronavirus has caused thousands of deaths due to several mechanisms of injury including acute kidney injury (AKI). Most of the patients have a fast progression of the disease leading to death in the second week of hospital admission, however, here we have a case of a 58-year-old female who died in less than 24 hours of admission due to severe metabolic acidosis, acute respiratory distress syndrome (ARDS) and renal failure.
AD  - Internal Medicine, MacNeal Hospital, Berwyn, USA.
Nephrology, MacNeal Hospital, Berwyn, USA.
AN  - 33014647
AU  - Espinoza, D.
AU  - Rodriguez, R.
AU  - Kowalski, A.
C1  - 10/6/2020
C2  - PMC7526959
DA  - Aug 31
DB  - PubMed
DO  - 10.7759/cureus.10149
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Cureus
KW  - acidosis
covid-19
cytokine storm
hemodialysis
mortality
renal failure
risk factors
LA  - eng
N1  - 2168-8184
Espinoza, Diana
Rodriguez, Raul
Kowalski, Andrew
Case Reports
Cureus. 2020 Aug 31;12(8):e10149. doi: 10.7759/cureus.10149.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10149
ST  - 24 Hours: A Case of Multiorgan Failure Associated With COVID-19
T2  - Cureus
TI  - 24 Hours: A Case of Multiorgan Failure Associated With COVID-19
VL  - 12
ID  - 7785380
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic in Indonesia started with 2 cases on March 2, 2020, and as of May 11, a total of 14�?65 people were infected. The government through Task Force for COVID-19 Rapid Response informs the progress of COVID-19 pandemic in Indonesia, but no one has provided a picture of the risk distribution in all provinces in Indonesia. This research is intended to identify high-risk provinces based on risk factors in each province and to find COVID-19 hotspots. This is an ecological study that used aggregate data. We used a map to present the risk distribution in Indonesia, and Local Indicators of Spatial Association (LISA) to define the hotspot area of COVID-19 in Indonesia. There are 6 provinces identified as high-risk areas of COVID-19 in Indonesia, and the hotspot provinces are Banten, DKI Jakarta, West Java, East Java, and Central Java.
AD  - Universitas Indonesia, Depok, Jawa Barat, Indonesia.
Universitas IPB, Depok, Indonesia.
AN  - 33016091
AU  - Eryando, T.
AU  - Sipahutar, T.
AU  - Rahardiantoro, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/1010539520962940
DP  - NLM
ET  - 2020/10/06
J2  - Asia-Pacific journal of public health
KW  - Covid-19
COVID-19 hotspot
Indonesia COVID-19
spatial COVID-19
LA  - eng
N1  - 1941-2479
Eryando, Tris
Sipahutar, Tiopan
Orcid: 0000-0002-5292-1261
Rahardiantoro, Septian
Journal Article
China
Asia Pac J Public Health. 2020 Oct 5:1010539520962940. doi: 10.1177/1010539520962940.
PY  - 2020
SN  - 1010-5395
SP  - 1010539520962940
ST  - The Risk Distribution of COVID-19 in Indonesia: A Spatial Analysis
T2  - Asia-Pacific journal of public health
TI  - The Risk Distribution of COVID-19 in Indonesia: A Spatial Analysis
ID  - 7785224
ER  - 

TY  - JOUR
AB  - It is desirable to better characterize and understand how ventilation improvements in office spaces could offer significant protection against transmission of COVID-19. It is also desirable to understand how ventilation in office spaces compares to outdoor settings. An attempt to find this information from online searches that included medical journals, private industry, and US government provided materials failed to find specific quantitative estimates and recommendations, which motivated this study. This study uses measured amounts of SARS-CoV-2 in the air of a hospital room with COVID-19 patients from a published and peer-reviewed study and known Influenza A challenge doses from a published and peer-reviewed study and known ASHRAE Office Ventilation standards and an Outdoor Air Exchange model to estimate the time necessary to cause various exposure levels and resulting infection potential in various indoor and outdoor settings of both Influenza A and COVID-19. While these estimations have unknown error margins and cannot be considered authoritative, they may have utility in comparing various environments and relative risk factors. The estimates in this study also present an initial framework and specific quantitative examples for better understanding of the effects of ventilation on aerosolized transmission, and the immunology related to challenge doses, and the potential for low-level viral load exposure to result in some level of immunity without symptoms of illness (asymptomatic infection). Specific quantitative examples of exposure viral load versus symptoms and immune response may Increase public understanding and consciousness of concepts such as viral load, exposure time, challenge dose levels, shedding quantities, immune seroconversion, and re-challenge and could achieve new levels of personal hygiene that complement centuries-old adages such as wash your hands.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThe authors performed all work on this study without compensation as an act of good will and statesmanship and have no beneficial affiliations with any institutions related to the work.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This is a meta-study that does not require IRB approval. We don&#039;t know if it requires EQUATOR Network submission and need assistance in this area.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe manuscript contains all relevant data and references.
AU  - Epperly, David E.
AU  - Caney, David N.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.03.20206110
DP  - medRxiv
PY  - 2020
SP  - 2020.10.03.20206110
ST  - COVID-19 Viral Loads, Environment, Ventilation, Masks, Exposure Time, And Severity : A Pragmatic Guide Of Estimates (preprint)
T2  - medRxiv
TI  - COVID-19 Viral Loads, Environment, Ventilation, Masks, Exposure Time, And Severity : A Pragmatic Guide Of Estimates (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.03.20206110.abstract
ID  - 7788866
ER  - 

TY  - JOUR
AN  - 2448415338
AU  - Emmert, Steffen
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/ddg.14186_g
DP  - ProQuest Central
IS  - 8
KW  - Medical Sciences--Dermatology And Venereology
COVID-19
LA  - English
N1  - Copyright - © 2020 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.
PY  - 2020
SN  - 16100379
SP  - 787-788
ST  - Die COVID�?9‐Pandemie �?wachsam bleiben!
T2  - Journal der Deutschen Dermatologischen Gesellschaft
TI  - Die COVID�?9‐Pandemie �?wachsam bleiben!
UR  - https://www.proquest.com/docview/2448415338?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=unknown&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Die+COVID%E2%80%9019%E2%80%90Pandemie+%26ndash%3B+wachsam+bleiben%21&title=Journal+der+Deutschen+Dermatologischen+Gesellschaft&issn=16100379&date=2020-08-01&volume=18&issue=8&spage=787&au=Emmert%2C+Steffen&isbn=&jtitle=Journal+der+Deutschen+Dermatologischen+Gesellschaft&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fddg.14186_g
VL  - 18
ID  - 7784913
ER  - 

TY  - JOUR
AB  - PURPOSE: To assess the concerns of the residents and young ophthalmologists as well as the change in their practice during the COVID era. DESIGN: This is an cross-sectional study. METHODS: A questionnaire was directed to the young Ophthalmologists of Ophthalmology department in Cairo University hospitals. The primary outcome measures were the effects of COVID-19 pandemic on ophthalmology practice. RESULTS: Seventy-nine young Ophthalmologists responded to the questionnaire, with an age ranging from 24 to 36 years of age of which 57% were females. They all practiced Ophthalmology from less than one year up to 9 years long, with 55.8% of them feeling unlucky starting ophthalmic practice during this era, 7.6% are extremely anxious regarding their psychological concern about the pandemic, and some feel they need psychological assessment especially those with 1-3 years duration of practice (41.2%) (p = .011) , especially females (82.4%, p = .015 ). As for access to PPE, 94.9% are wearing masks in the clinic, but only 8.9% of patients are wearing masks. Before this lockdown, 16.7% of the enrolled candidates attended on line lectures and webinars, but since then, this has significantly surged to 80.5% (p  .001) . CONCLUSION: Due to COVID-19 pandemic, as with everybody else, our young ophthalmologists have been affected on many different levels; psychologically, education and practice levels.
AD  - Department of Ophthalmology, Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University , Cairo, Egypt.
AN  - 33017198
AU  - El-Saied, H. M. A.
AU  - Salah Eddin Abdelhakim, M. A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1080/08820538.2020.1826046
DP  - NLM
ET  - 2020/10/06
J2  - Seminars in ophthalmology
KW  - Covid-19
Cairo University hospitals
pandemic
personal protective equipment (PPE)
young ophthalmologists
LA  - eng
N1  - 1744-5205
El-Saied, Heba Magdy Ahmed
Salah Eddin Abdelhakim, Mohamad Amr
Journal Article
England
Semin Ophthalmol. 2020 Oct 5:1-11. doi: 10.1080/08820538.2020.1826046.
PY  - 2020
SN  - 0882-0538
SP  - 1-11
ST  - Impact of COVID-19 Pandemic on Young Ophthalmologists in Cairo University Hospitals
T2  - Seminars in ophthalmology
TI  - Impact of COVID-19 Pandemic on Young Ophthalmologists in Cairo University Hospitals
ID  - 7785153
ER  - 

TY  - JOUR
AB  - This study aimed at exploring the gender-specific changes in physical activity level (PAL) and associated factors amid the COVID-19 pandemic and social distancing, among adolescents. Sixty-three healthy adolescents (14-18 years) were assessed at the baseline (before social distancing imposition) for PAL (BL-PAL) and fitness variables; and next at the follow-up (2 months following social distancing commencement) for PAL (FU-PAL). A significant PAL decline was evidenced for the entire sample (P  .001) that was notably affected by PAL shifts among boys (P  .001) rather than girls (P = .07). Consistently, fitness variables (explosive strength, flexibility, and aerobic endurance) were positively correlated with BL-PAL and FU-PAL for boys and girls, where clearest associations were observed between baseline strength and aerobic endurance with PAL. With remarkable PAL declines among adolescents in challenging situations, like the COVID-19 pandemic, physical literacy is essential to preserve PAL.
AD  - Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Department of Basic Sciences, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
AN  - 33016086
AU  - Elnaggar, R. K.
AU  - Alqahtani, B. A.
AU  - Mahmoud, W. S.
AU  - Elfakharany, M. S.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1177/1010539520963564
DP  - NLM
ET  - 2020/10/06
J2  - Asia-Pacific journal of public health
KW  - COVID-19 epidemic
adolescents
aerobic endurance capacity
physical activity
physical literacy
LA  - eng
N1  - 1941-2479
Elnaggar, Ragab K
Orcid: 0000-0001-5080-702x
Alqahtani, Bader A
Mahmoud, Waleed S
Elfakharany, Mahmoud S
Journal Article
China
Asia Pac J Public Health. 2020 Oct 3:1010539520963564. doi: 10.1177/1010539520963564.
PY  - 2020
SN  - 1010-5395
SP  - 1010539520963564
ST  - Physical Activity in Adolescents During the Social Distancing Policies of the COVID-19 Pandemic
T2  - Asia-Pacific journal of public health
TI  - Physical Activity in Adolescents During the Social Distancing Policies of the COVID-19 Pandemic
ID  - 7785226
ER  - 

TY  - JOUR
AB  - OBJECTIVE: ACE2 long served as the human gateway for multiple coronaviruses, including the currently pandemic SARS-CoV-2. This mini-review explores the potential of targeting ACE2 in blocking viral penetrance. MATERIALS AND METHODS: PubMed search was conducted using the terms: "coronaviridae", "peptidyl-dipeptidase A", "ACE2", "SARS", and "SARS-CoV-2". References of relevant articles were further screened by the author. RESULTS: Four main methods of blocking ACE2-mediated viral penetrance were identified: receptor blockage, receptor decoying, receptor shedding, and co-receptor inhibition. CONCLUSIONS: Drugs that inhibit viral binding to ACE2 present a strong choice for the current, and if necessary, future outbreaks. Further research is needed to establish the clinical and pharmacological aspects of the identified candidate molecules.
AD  - Faculty of Medicine, Mansoura University, Mansoura, Egypt. ramiamjad1@gmail.com.
AN  - 33015820
AU  - Elmorsi, R.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23067
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Elmorsi, R
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9744-9747. doi: 10.26355/eurrev_202009_23067.
PY  - 2020
SN  - 1128-3602
SP  - 9744-9747
ST  - The therapeutic potential of targeting ACE2 in COVID-19
T2  - European review for medical and pharmacological sciences
TI  - The therapeutic potential of targeting ACE2 in COVID-19
VL  - 24
ID  - 7785245
ER  - 

TY  - JOUR
AU  - Elkady, Ahmed
AU  - Rabinstein, Alejandro A.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Acute necrotizing encephalopathy and myocarditis in a young patient with COVID-19
T2  - Neurology-Neuroimmunology & Neuroinflammation
TI  - Acute necrotizing encephalopathy and myocarditis in a young patient with COVID-19
UR  - https://doi.org/10.1212/nxi.0000000000000801
ID  - 7788348
ER  - 

TY  - JOUR
AU  - Elghoudi, Ahmed
AU  - Aldhanhani, Huda
AU  - Ghatasheh, Ghassan
AU  - Sharif, Elsadeq
AU  - Narchi, Hassib
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - 2019-nCoV, children, coronavirus, COVID-19, SARS-CoV2, prevalence
PY  - 2020
ST  - Children with Confirmed COVID-19 Managed in Al Ain Hospital, United Arab Emirates: A Different Narrative and Review of the Literature (preprint)
T2  - SSRN
TI  - Children with Confirmed COVID-19 Managed in Al Ain Hospital, United Arab Emirates: A Different Narrative and Review of the Literature (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3674078
ID  - 7788898
ER  - 

TY  - GEN
AN  - NCT04576299
AU  - Elche, Universidad Miguel Hernandez de
AU  - Santander, Universidad de
AU  - Nariño, Universidad Antonio
AU  - Paulo, University of Sao
AU  - Guayaquil, Universidad Catolica Santiago de
AU  - Chile, Pontificia Universidad Catolica de
C1  - 10/6/2020
DA  - September 1
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Patient Safety
N1  - No Results Available
Other: Group 1
Patient Safety perception.
All
800
Other
Observational Model: Ecologic or Community|Time Perspective: Cross-Sectional
2020-09
December 15, 2020
PB  - https://ClinicalTrials.gov/show/NCT04576299
PY  - 2020
ST  - Health Care Workers' Perception of Patient Safety During COVID-19 Pandemic
T2  - ClinicalTrials
TI  - Health Care Workers' Perception of Patient Safety During COVID-19 Pandemic
UR  - https://ClinicalTrials.gov/show/NCT04576299
ID  - 7788863
ER  - 

TY  - JOUR
AU  - Eaton, Adrienne
AU  - Heckscher, Charles
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID's impacts on the Field of Labor and Employment Relations
T2  - Journal of Management Studies
TI  - COVID's impacts on the Field of Labor and Employment Relations
UR  - https://doi.org/10.1111/joms.12645
ID  - 7788292
ER  - 

TY  - JOUR
AB  - COVID-19 is a pandemic which has entered its sixth month and is evolving in children. Besides respiratory problems, it is also known now for non-respiratory problems in children. We systematically searched the relevant articles up till June 2020. Just like in SARS-COV, MERS-COV, children are developing fewer symptoms in SARS-COV2 as compared to adults. Evidence suggests that the chances of children getting infected is same as adults but are less likely to develop severe symptoms. However, studies in various regions have shown children showing gastrointestinal symptoms, chilblain-like disease which some doctors are referring to as covid toes. MIS-C, whose pathophysiology is similar to Kawasaki syndrome. In this review, we focus on the symptoms arising in chil dren and the treatment given to clear some of those symptoms. Copyright © 2020, Global Research Online. All rights reserved.
AD  - (Dutta, Bhyan, Khetwal, Jain) Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, India (Ghosh) Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, India
S. Dutta, Department of Pharmacy Practice, Teerthanker Mahaveer College of Pharmacy, TMU, Moradabad, Uttar Pradesh, India. E-mail: shankydutta123@gmail.com
AN  - 2005150344
AU  - Dutta, S.
AU  - Bhyan, S. J.
AU  - Ghosh, A. K.
AU  - Khetwal, K.
AU  - Jain, S.
C1  - 10/6/2020
DA  - September-October
DB  - Embase
DO  - http://dx.doi.org/10.47583/ijpsrr.2020.v64i01.015
DP  - Ovid Technologies
IS  - 1
KW  - Chilblain-like lesions
covid-19
Gastrointestinal symptoms
mis-c
Pediatrics
adult
chilblain
child
coronavirus disease 2019
gastrointestinal symptom
human
Middle East respiratory syndrome coronavirus
mucocutaneous lymph node syndrome
nonhuman
pandemic
review
Severe acute respiratory syndrome coronavirus 2
toe
LA  - English
M3  - Review
PY  - 2020
SN  - 0976-044X
SP  - 75-79
ST  - Effect of covid-19 in paediatric population: Review of recent studies
T2  - International Journal of Pharmaceutical Sciences Review and Research
TI  - Effect of covid-19 in paediatric population: Review of recent studies
UR  - http://globalresearchonline.net/journalcontents/v64-1/15.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005150344
VL  - 64
ID  - 7782987
ER  - 

TY  - JOUR
AB  - Background: The 2019-nCoV which is regarded as a novel coronavirus is a positive-sense single-stranded RNA virus. It is infectious to humans and is the cause of the ongoing coronavirus outbreak which has elicited an emergency in public health and a call for immediate international concern has been linked to it. The coronavirus main proteinase which is also known as the 3C-like protease (3CLpro) is a very important protein in all coronaviruses for the role it plays in the replication of the virus and the proteolytic processing of the viral polyproteins. The resultant cytotoxic effect which is a product of consistent viral replication and proteolytic processing of polyproteins can be greatly reduced through the inhibition of the viral main proteinase activities. This makes the 3C-like protease of the coronavirus a potential and promising target for therapeutic agents against the viral infection. Results: This study describes the detailed computational process by which the 2019-nCoV main proteinase coding sequence was mapped out from the viral full genome, translated and the resultant amino acid sequence used in modeling the protein 3D structure. Comparative physiochemical studies were carried out on the resultant target protein and its template while selected HIV protease inhibitors were docked against the protein binding sites which contained no co-crystallized ligand. Conclusion: In line with results from this study which has shown great consistency with other scientific findings on coronaviruses, we recommend the administration of the selected HIV protease inhibitors as first-line therapeutic agents for the treatment of the current coronavirus epidemic. [ABSTRACT FROM AUTHOR]
Copyright of Egyptian Journal of Medical Human Genetics is the property of Egyptian Society of Human Genetics and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
AN  - 146197194
AU  - Durojaye, Olanrewaju Ayodeji
AU  - Mushiana, Talifhani
AU  - Uzoeto, Henrietta Onyinye
AU  - Cosmas, Samuel
AU  - Udowo, Victor Malachy
AU  - Osotuyi, Abayomi Gaius
AU  - Ibiang, Glory Omini
AU  - Gonlepa, Miapeh Kous
C1  - 10/6/2020
DB  - a9h
DO  - 10.1186/s43042-020-00081-5
DP  - EBSCOhost
IS  - 1
KW  - Coronavirus
Inhibitors
Ligand
Proteinase
Replication
M3  - Article
N1  - Durojaye, Olanrewaju Ayodeji 1,2,3; Email Address: lanredurojaye@mail.ustc.edu.cn Mushiana, Talifhani 4 Uzoeto, Henrietta Onyinye 5 Cosmas, Samuel 2 Udowo, Victor Malachy 6 Osotuyi, Abayomi Gaius 7 Ibiang, Glory Omini 5 Gonlepa, Miapeh Kous 8; Affiliation: 1: School of Life Sciences, Department of Molecular and Cell Biology, University of Science and Technology of China, Hefei, China 2: Department of Biochemistry, University of Nigeria, Nsukka, Enugu State, Nigeria 3: Department of Chemical Sciences, Coal City University, Emene, Enugu State, Nigeria 4: School of Chemistry and Material Sciences, Department of Chemistry, University of Science and Technology of China, Hefei, China 5: Department of Biological Sciences, Coal City University, Emene, Enugu State, Nigeria 6: Institute of Metal Research, Chinese Academy of Sciences, Shenyang, China 7: School of Earth and Space Sciences, University of Science and Technology of China, Hefei, China 8: School of Public Affairs, Department of Public Administration, University of Science and Technology of China, Hefei, China; Source Info: 10/2/2020, Vol. 21 Issue 1, p1; Author-Supplied Keyword: Coronavirus; Author-Supplied Keyword: Inhibitors; Author-Supplied Keyword: Ligand; Author-Supplied Keyword: Proteinase; Author-Supplied Keyword: Replication; Number of Pages: 17p; Document Type: Article; Full Text Word Count: 9766
PY  - 2020
SN  - 11108630
SP  - 1-17
ST  - Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking study
T2  - Egyptian Journal of Medical Human Genetics
TI  - Potential therapeutic target identification in the novel 2019 coronavirus: insight from homology modeling and blind docking study
UR  - http://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=146197194&site=ehost-live
VL  - 21
ID  - 7783344
ER  - 

TY  - JOUR
AB  - Medical care of adults with disabilities, especially those with intellectual disabilities, can be ethically difficult. Several questions arise frequently. Can we administer a life-saving treatment that could impact negatively the patient&#039;s quality of life when the patient isn&#039;t able to give consent? During this Covid-19 period, can the use of chemical or physical restraints be considered as mistreatment, whereas the aim is to protect others? These are situations where the ethical question holds a central role. Although each clinical situation is unique, this article highlights, through four clinical cases, the ethical principles that should guide physicians in their decision-making process.
AU  - Dugerdil, Adeline
AU  - Deriaz, Jonathan
AU  - Hurst-Majno, Samia
AU  - Dominicé Dao, Melissa
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 708
LA  - fr
PY  - 2020
SP  - 1790-1795
ST  - Questions éthiques soulevées par la prise en charge médicale des adultes en situation de handicap
T2  - Rev Med Suisse
TI  - Questions éthiques soulevées par la prise en charge médicale des adultes en situation de handicap
TT  - [Ethical questions regarding the medical care of adults with disabilities].
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-812997
VL  - 16
ID  - 7788459
ER  - 

TY  - JOUR
AB  - In the United States, rural areas have a higher burden of type 2 diabetes (T2DM) compared to urban areas. However, there is limited information on risk factors and interventions that improve the primary prevention and management of T2DM in rural areas. To synthesize current knowledge on T2DM in rural areas and to guide healthcare providers and policy makers, we reviewed five scientific databases and the grey literature over the last decade (2010-2020). We described classification systems for rurality and the T2DM burden based on rurality and region (West, South, Midwest, and Northeast). We highlighted risk factors for T2DM in rural compared to urban areas, and summarized interventions to screen and manage T2DM based on opportunistic screening, T2DM self-management, community-based initiatives, as well as interventions targeting comorbidities and T2DM. Several studies identified the co-existence of T2DM and depression/psychological symptoms, which could reduce adherence to non-pharmacologic and pharmacologic management of T2DM. We highlighted the role of technology in education and counselling of patients with geographic and financial barriers to accessing care, which is exacerbated by the SARS-CoV-2 coronavirus disease-19 pandemic. We identified knowledge gaps and next steps in improving T2DM care in rural areas. There is an urgent need for interventions tailored to rural areas given that rural Americans currently experience a disproportionate burden of T2DM and are encumbered by its associated morbidity, mortality, and loss in economic productivity.
AD  - Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Division of Endocrinology, Mayo Clinic, Rochester, Minnesota, USA.
AN  - 33021052
AU  - Dugani, S. B.
AU  - Mielke, M. M.
AU  - Vella, A.
C1  - 10/6/2020
DA  - Sep 25
DB  - PubMed
DO  - 10.1002/dmrr.3410
DP  - NLM
ET  - 2020/10/07
J2  - Diabetes/metabolism research and reviews
KW  - primary prevention
rural health
type 2 diabetes mellitus
urban-rural disparities
LA  - eng
N1  - 1520-7560
Dugani, Sagar B
Orcid: 0000-0001-7858-1317
Mielke, Michelle M
Vella, Adrian
AG49704/AG/NIA NIH HHS/United States
Robert and Elizabeth Strickland Career Development Award/
Journal Article
England
Diabetes Metab Res Rev. 2020 Sep 25:e3410. doi: 10.1002/dmrr.3410.
PY  - 2020
SN  - 1520-7552
SP  - e3410
ST  - Burden and management of type 2 diabetes in rural United States
T2  - Diabetes/metabolism research and reviews
TI  - Burden and management of type 2 diabetes in rural United States
ID  - 7784960
ER  - 

TY  - JOUR
AB  - BACKGROUND: Patients with COVID-19 infection requiring in-hospital care are frequently managed by Internal Medicine hospitalists, comprised of physicians, nurse practitioners and physician assistants. There is sparse information on the psychological impact of the COVID-19 pandemic on Internal Medicine hospitalists. METHODS: We surveyed Internal Medicine hospitalists at Mayo Clinic sites in four states (Arizona, Florida, Minnesota, and Wisconsin). We collected demographic information, and used Patient-Reported Outcomes Measurement Information System (PROMIS�]) measures to assess global well-being, anxiety, social isolation, and emotional support. Descriptive statistics were used to compare responses between two periods: prior to the pandemic (before March 15(th), 2020), and during the pandemic (March 15 through April 30, 2020). The survey was conducted from May 4-25, 2020. RESULTS: Of 295 Internal Medicine hospitalists, 154 (52%) responded. Fifty-six percent were women (n=85/154) and 54% were physicians (n=84/154). Most hospitalists (75%; n=115/154) reported concerns about contracting COVID-19 infection at work, and 5% (n=8/154) reported changing where they lived during the pandemic. Most hospitalists (73%; n=112/154) reported relying primarily on institutional resources for COVID-19 information. During the pandemic, the percentage of participants with excellent or very good global well-being decreased (90% prior to pandemic vs. 53% during pandemic), with increases in mean anxiety (-4.88 [95% confidence interval, -5.61 to -4.16]; P.001) and social isolation (-3.91[95% confidence interval, -4.68 to -3.13]; P.001). During the same period, there was a small decrease in mean emotional support (1.46 [95% confidence interval, 0.83 to 2.09]; P.001). CONCLUSION: During the COVID-19 pandemic, Internal Medicine hospitalists reported lower global well-being, higher anxiety and social isolation, and a small decrease in emotional support. These results provide a framework to develop programs to support hospitalists and potentially mitigate long-term psychological sequelae including burnout.
AD  - Rochester, Minnesota, United States.
Mayo Clinic Scottsdale , Scottsdale, Arizona, United States.
Mayo Clinic Hospital Jacksonville - Internal Medicine , Jacksonville, Florida, United States.
Mayo Clinic , Rochester, Minnesota, United States.
AN  - 33012183
AU  - Dugani, S. B.
AU  - Geyer, H. L.
AU  - Maniaci, M. J.
AU  - Fischer, K.
AU  - Croghan, I.
AU  - Burton, C.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1080/21548331.2020.1832792
DP  - NLM
ET  - 2020/10/06
J2  - Hospital practice (1995)
KW  - COVID-19 infection
anxiety
emotional support
hospital medicine
provider burnout
social isolation
well-being
LA  - eng
N1  - Dugani, Sagar B
Geyer, Holly L
Maniaci, Michael J
Fischer, Karen
Croghan, Ivana
Burton, Caroline
Journal Article
England
Hosp Pract (1995). 2020 Oct 3. doi: 10.1080/21548331.2020.1832792.
PY  - 2020
SN  - 2154-8331 (Print)
2154-8331
ST  - Psychological wellness of internal medicine hospitalists during the COVID-19 pandemic
T2  - Hospital practice (1995)
TI  - Psychological wellness of internal medicine hospitalists during the COVID-19 pandemic
ID  - 7785613
ER  - 

TY  - JOUR
AB  - Identifying and isolating individuals infected with COVID-19 are critical steps in stopping the spread of the coronavirus. Until widespread testing and contact tracing systems are implemented, alternative methods must be considered. One way that organizations can protect employees and clients is by creating their own automated health attestation systems. These systems could be used to reduce the spread of the coronavirus by asking providers and consumers to self-identify COVID-19 exposure, as well as to help mitigate liability for organizations by asking providers and consumers to agree to follow relevant policies and acknowledge the risks inherent in providing or receiving services. The purpose of this article is to outline the steps for creating this type of health attestation system using Microsoft Office 365.
AD  - Department of Special Education, Early Childhood, and Prevention Science, University of Louisville, Louisville, KY USA. GRID: grid.266623.5. ISNI: 0000 0001 2113 1622
Kent School of Social Work, University of Louisville, Louisville, KY USA. GRID: grid.266623.5. ISNI: 0000 0001 2113 1622
Norton Children's Autism Center, Louisville, KY USA.
LittleStar ABA Therapy, Clarksville, IN USA.
AN  - 33014310
AU  - Dubuque, E. M.
AU  - Yingling, M. E.
AU  - Ranade, E. S.
AU  - Dubuque, M. L.
C1  - 10/6/2020
C2  - PMC7521569
DA  - Sep 28
DB  - PubMed
DO  - 10.1007/s40617-020-00495-y
DP  - NLM
ET  - 2020/10/06
J2  - Behavior analysis in practice
KW  - Covid-19
Coronavirus
Health attestations
Microsoft
Procedural safeguards
Tutorial
LA  - eng
N1  - 2196-8934
Dubuque, Erick M
Orcid: 0000-0002-3562-7554
Yingling, Marissa E
Ranade, Erica S
Dubuque, Molly L
Journal Article
Behav Anal Pract. 2020 Sep 28:1-12. doi: 10.1007/s40617-020-00495-y.
PY  - 2020
SN  - 1998-1929 (Print)
1998-1929
SP  - 1-12
ST  - Creating an Automated Health Attestation System During the COVID-19 Pandemic with Microsoft 365
T2  - Behavior analysis in practice
TI  - Creating an Automated Health Attestation System During the COVID-19 Pandemic with Microsoft 365
ID  - 7785408
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To describe COVID-19 hospitalized health worker cases in Brazil. METHODS: This was a descriptive case series study; it included cases that became ill between February 21st and April 15th, 2020 registered on the Influenza Surveillance Information System (SIVEP-Gripe, acronym in Portuguese). RESULTS: Of the 184 cases, 110 (59.8%) were female and median age was 44 years (min-max: 23-85); 89 (48.4%) were nursing professionals and 50 (27.2%) were doctors. Ninety-two (50.0%) presented comorbidity, with heart disease predominating (n=37; 40.2%). Of the 112 professionals with a record of case progression, 85 (75.9%) were cured and 27 (24.1%) died, 18 of whom were male. CONCLUSION: The profile of COVID-19 hospitalized health workers is similar to that of the general population with regard to age and comorbidities, but different in relation to sex. The most affected areas were nursing and medicine.
AU  - Duarte, Magda Machado Saraiva
AU  - Haslett, Maria Isabella Claudino
AU  - Freitas, Leonardo José Alves de
AU  - Gomes, Nivreanes Tcherno Nulle
AU  - Silva, Danielle Cristine Castanha da
AU  - Percio, Jadher
AU  - Wada, Marcelo Yoshito
AU  - Fantinato, Francieli Fontana Sutile Tardetti
AU  - Almeida, Walquiria Aparecida Ferreira de
AU  - Silva, Daiana Araujo da
AU  - Gava, Caroline
AU  - França, Giovanny Vin�Tcius Araújo de
AU  - Mac֙rio, Eduardo Marques
AU  - Ba�^ta, Karla Freire
AU  - Malta, Juliane Maria Alves Siqueira
AU  - Alves, Ana Julia Silva E.
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 5
LA  - en
PY  - 2020
SP  - e2020277-e2020277
ST  - Descrição dos casos hospitalizados pela COVID-19 em profissionais de saúde nas primeiras nove semanas da pandemia, Brasil, 2020
T2  - Epidemiol Serv Saude
TI  - Descrição dos casos hospitalizados pela COVID-19 em profissionais de saúde nas primeiras nove semanas da pandemia, Brasil, 2020
TT  - Descrição dos casos hospitalizados pela COVID-19 em profissionais de saúde nas primeiras nove semanas da pandemia, Brasil, 2020.
Description of COVID-19 hospitalized health worker cases in the first nine weeks of the pandemic, Brazil, 2020.
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-810133
VL  - 29
ID  - 7788745
ER  - 

TY  - JOUR
AB  - BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic affects the education of medical students around the world and countries have had differing responses in dealing with this dynamic situation. The role of medical students in fighting this pandemic is controversial and it is yet to be elucidated how they can best be of service. The aim of this study is to evaluate the working fields of volunteering students and the impact of the pandemic on final year students from a student's perspective. METHODS: An anonymous online survey was conducted amongst 219 medical students from Hamburg (Germany), using an institutional online data collection program. RESULTS: A total of 137 questionnaires (63.5%) were completed. Of these, 97 participants were students from academic year three to five (70.8%) and 40 students were in the final year of medical school (29.2%). Of the 97 students from academic year three to five, 68 students (70.1%) signed up for voluntary duties during the pandemic. Interestingly, only 25.0% of the students were called for voluntary work in hospitals or health authorities. Final year students had already been working in hospitals since before the outbreak, with 35.0% of them assisting doctors in the treatment of COVID-19 positive patients during their placements. Using a 5-Point Likert Scale, the students who volunteered self-assessed their work as more useful and received more gratitude than final year students (p0.01). CONCLUSIONS: The majority of medical students are willing to make a significant contribution in the response to COVID-19 and do not wish to be overlooked. Furthermore, the current pandemic offers novel educational opportunities for medical students.
AD  - Neurological Surgery, Semmelweis University, Hamburg, DEU.
Surgery, Semmelweis University, Hamburg, DEU.
AN  - 33014645
AU  - Drexler, R.
AU  - Hambrecht, J. M.
AU  - Oldhafer, K. J.
C1  - 10/6/2020
C2  - PMC7526758
DA  - Aug 30
DB  - PubMed
DO  - 10.7759/cureus.10147
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Cureus
KW  - covid
covid-19
education
medical education
medical school
medical student
pandemic
student
volunteer work
LA  - eng
N1  - 2168-8184
Drexler, Richard
Hambrecht, Jan M
Oldhafer, Karl J
Journal Article
Cureus. 2020 Aug 30;12(8):e10147. doi: 10.7759/cureus.10147.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10147
ST  - Involvement of Medical Students During the Coronavirus Disease 2019 Pandemic: A Cross-Sectional Survey Study
T2  - Cureus
TI  - Involvement of Medical Students During the Coronavirus Disease 2019 Pandemic: A Cross-Sectional Survey Study
VL  - 12
ID  - 7785381
ER  - 

TY  - JOUR
AB  - Standard operating procedures drive everyday practice within any organization, including those within a forensic setting. In the event of unusual circumstances, organizations must respond rapidly to address the impact on operations while ensuring that the quality and safety outcomes of routine services are not affected. This case study illustrates how standard operating procedures can be newly developed or modified, and rapidly deployed and quickly revised, to address unusual circumstances. The response to the COVID-19 pandemic is used as an example in this case report.
AD  - Author Affiliations: Texas A&M University.
Harris County Institute of Forensic Sciences.
Rush University.
AN  - 33017342
AU  - Drake, S. A.
AU  - Pierce, M.
AU  - Gumpeni, P.
AU  - Giardino, E.
AU  - Wolf, D. A.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1097/jfn.0000000000000305
DP  - NLM
ET  - 2020/10/06
J2  - Journal of forensic nursing
LA  - eng
N1  - 1939-3938
Drake, Stacy A
Pierce, Michal
Gumpeni, Parmod
Giardino, Eileen
Wolf, Dwayne A
Journal Article
United States
J Forensic Nurs. 2020 Oct 2. doi: 10.1097/JFN.0000000000000305.
PY  - 2020
SN  - 1556-3693
ST  - Quality Assurance Through Standard Operating Procedures Development and Deviation: A Medicolegal Death Investigation Systems Response to the COVID-19 Pandemic
T2  - Journal of forensic nursing
TI  - Quality Assurance Through Standard Operating Procedures Development and Deviation: A Medicolegal Death Investigation Systems Response to the COVID-19 Pandemic
ID  - 7785142
ER  - 

TY  - JOUR
AB  - The novel coronavirus (SARS-CoV-2) pandemic has influenced the timeliness of care for patients with both common and rare conditions, particularly those affecting high-risk operative sites such as the upper aerodigestive tract. Sinonasal undifferentiated carcinoma (SNUC) represents a rare malignancy of the sinonasal tract, a unique subset of which has never been previously reported in the otolaryngology literature and is characterized by inactivation of the SMARCB (INI-1) tumor suppressor gene. This subtype exhibits a particularly poor prognosis and is characterized pathologically by its rhabdoid appearance. Here we present the case of an individual who was diagnosed with a sinonasal mass during the SARS-CoV-2 pandemic, which was ultimately found to be SMARCB (INI-1)-deficient sinonasal carcinoma. Advanced imaging was deferred in the interest of limiting the patient's exposure to the virus, and expedited operative management was performed which facilitated prompt referral for adjuvant chemoradiation. The SARS-CoV-2 pandemic presents unique challenges, but the work-up of high-risk lesions must be prioritized; this continues to be paramount as SARS-CoV-2 resurges in many cities across the USA.
AD  - Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA, jennifer.douglas@pennmedicine.upenn.edu.
Department of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
AN  - 33017834
AU  - Douglas, J. E.
AU  - Kaufman, A. C.
AU  - Rajasekaran, K.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1159/000511713
DP  - NLM
ET  - 2020/10/06
J2  - ORL; journal for oto-rhino-laryngology and its related specialties
KW  - Covid-19
SMARCB-deficient carcinoma
Sinonasal cancer
Sinonasal undifferentiated carcinoma
Skull base surgery
LA  - eng
N1  - 1423-0275
Douglas, Jennifer E
Kaufman, Adam C
Rajasekaran, Karthik
Case Reports
Switzerland
ORL J Otorhinolaryngol Relat Spec. 2020 Oct 5:1-5. doi: 10.1159/000511713.
PY  - 2020
SN  - 0301-1569
SP  - 1-5
ST  - Management of a Unique Sinonasal Undifferentiated Carcinoma Subtype in the Era of SARS-CoV-2
T2  - ORL; journal for oto-rhino-laryngology and its related specialties
TI  - Management of a Unique Sinonasal Undifferentiated Carcinoma Subtype in the Era of SARS-CoV-2
ID  - 7785117
ER  - 

TY  - JOUR
AD  - Department of Epidemiology, School of Public Health and Research Center for Health Sciences, Hamadan University of Medical Sciences, Hamadan, Iran.
Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran.
Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
AN  - 33015615
AU  - Doosti-Irani, A.
AU  - Mostafavi, E.
AU  - Nazemipour, M.
AU  - Mansournia, M. A.
AU  - Haghdoost, A. A.
C1  - 10/6/2020
C2  - PMC7525261 Haghdoost is the Deputy Minister of Education of Ministry of Health and Medical Education (MOHME), and the director of the national committee of Epidemiology of COVID-19, in MOHME, Iran. The rest of the authors have no conflict of interest to disclose.
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.gloepi.2020.100035
DP  - NLM
ET  - 2020/10/06
J2  - Global epidemiology
LA  - eng
N1  - 2590-1133
Doosti-Irani, Amin
Mostafavi, Ehsan
Nazemipour, Maryam
Mansournia, Mohammad Ali
Haghdoost, Ali-Akbar
Journal Article
Glob Epidemiol. 2020 Sep 30:100035. doi: 10.1016/j.gloepi.2020.100035.
PY  - 2020
SN  - 2590-1133
SP  - 100035
ST  - Challenges for management of the COVID-19 epidemic in Iran
T2  - Global epidemiology
TI  - Challenges for management of the COVID-19 epidemic in Iran
ID  - 7785275
ER  - 

TY  - JOUR
AB  - Long-term home confinement during the ongoing COVID-19 can have negative mental and physical health consequences, which in turn can reduce productivity among those working remotely. We sought to delineate factors related to neuro-behavioral economics that employers should consider for their employees who are teleworking during the current Covid-19 pandemic. Physical and mental well-being are intertwined and are strongly correlated to high productivity at workplace. By integrating the factors of neuro-behavioral economics into the work culture, companies will alleviate work-related stress leading to improved mental and physical functioning; thus leading to increased productivity.
AD  - Center of Excellence in Health Equity, Training, and Research, Baylor College of Medicine, Houston, TX, USA.
College of Nursing and Public Health, Adelphi University, Garden City, NY, USA.
Department of Family and Community Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Department of Family and Community Medicine, Baylor College of Medicine, Houston, TX, USA.
AN  - 33014623
AU  - Dongarwar, D.
AU  - Yusuf, K. K.
AU  - Maiyegun, S. O.
AU  - Ibrahimi, S.
AU  - Ikedionwu, C.
AU  - Salihu, H. M.
C1  - 10/6/2020
C2  - PMC7520886
DB  - PubMed
DO  - 10.21106/ijma.399
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - International journal of MCH and AIDS
KW  - Covid-19
Mental health
Neuro-behavioral economics
Teleworking
LA  - eng
N1  - 2161-864x
Dongarwar, Deepa
Yusuf, Korede K
Maiyegun, Sitratullah O
Ibrahimi, Sahra
Ikedionwu, Chioma
Salihu, Hamisu M
Journal Article
Int J MCH AIDS. 2020;9(3):360-363. doi: 10.21106/ijma.399. Epub 2020 Sep 15.
PY  - 2020
SN  - 2161-8674 (Print)
2161-864x
SP  - 360-363
ST  - Covid-19 and Neuro-Behavioral Economics: A Conceptual Framework to Improve Physical and Mental Health among Remote Workers
T2  - International journal of MCH and AIDS
TI  - Covid-19 and Neuro-Behavioral Economics: A Conceptual Framework to Improve Physical and Mental Health among Remote Workers
VL  - 9
ID  - 7785388
ER  - 

TY  - JOUR
AB  - Attendance at conferences as part of undergraduate studies is key in health professional education for exploring speciality interests, sharing research, exchanging expertise and passing on knowledge. In addition, conferences offer valuable opportunities to present work and the potential to win prizes and network with others in the field. This article provides insight and guidance into how student-led and designed health science and education conferences can be implemented more effectively. It is aimed at students hoping to organise conferences and also to clinical educators and staff who help facilitate these. We present recommendations, a framework of steps to be followed and a case study, as well as an exploration of the challenges that COVID-19 has presented and how these have been overcome.
AD  - 1 - Barts and the London School of Medicine, Queen Mary University of London, London, UK.
AN  - 33015968
AU  - Dominic, C.
AU  - Bhalla, G.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/tct.13260
DP  - NLM
ET  - 2020/10/06
J2  - The clinical teacher
LA  - eng
N1  - 1743-498x
Dominic, Catherine
Orcid: 0000-0003-3048-4205
Bhalla, Gaurav
Orcid: 0000-0003-0337-3809
Journal Article
England
Clin Teach. 2020 Oct 5. doi: 10.1111/tct.13260.
PY  - 2020
SN  - 1743-4971
ST  - A framework for student-led education conferences
T2  - clinical teacher
TI  - A framework for student-led education conferences
ID  - 7785231
ER  - 

TY  - JOUR
AD  - 8785 Department of Humanities and Social Sciences, University of California, San Francisco, CA, USA.
8785 Department of Epidemiology and Biostatistics, University of California, San Francisco, CA, USA.
AN  - 33019867
AU  - Dolan, B.
AU  - Rutherford, G.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/0033354920961132
DP  - NLM
ET  - 2020/10/07
J2  - Public health reports (Washington, D.C. : 1974)
KW  - Covid-19
history
pandemic preparedness
social distancing
LA  - eng
N1  - 1468-2877
Dolan, Brian
Orcid: 0000-0002-7935-8915
Rutherford, George
Journal Article
United States
Public Health Rep. 2020 Oct 5:33354920961132. doi: 10.1177/0033354920961132.
PY  - 2020
SN  - 0033-3549
SP  - 33354920961132
ST  - How History of Medicine Helps Us Understand COVID-19 Challenges
T2  - Public health reports (Washington, DC : 1974)
TI  - How History of Medicine Helps Us Understand COVID-19 Challenges
ID  - 7785079
ER  - 

TY  - JOUR
AB  - Background Extracorporeal membrane oxygenation (ECMO) can be life-saving in cases of coronavirus disease (COVID-19);however, circuit thrombosis is a complication This report describes a COVID-19 patient treated with nafamostat and heparin to prevent circuit thrombosis during ECMO support Case presentation A 63-year-old man was transferred to our hospital with respiratory failure due to COVID-19 pneumonia He was provided venous-venous ECMO to maintain oxygenation During ECMO support, occlusive circuit thrombosis developed despite systemic anticoagulation therapy with heparin He was subsequently administered combination therapy with nafamostat and heparin Although the combination therapy could prevent circuit thrombosis, it was converted to heparin monotherapy because of hyperkalemia and hemothorax After tracheostomy and a gradual improvement in oxygenation, ECMO was discontinued He was transferred to another hospital for further rehabilitation Conclusion Combination therapy with nafamostat and heparin can prevent circuit thrombosis during ECMO However, bleeding can still develop with this combination therapy during ECMO
AU  - Doi, Shunichi
AU  - Akashi, Yoshihiro J.
AU  - Takita, Mumon
AU  - Yoshida, Hideki
AU  - Morikawa, Daiki
AU  - Ishibashi, Yuki
AU  - Higuma, Takumi
AU  - Fujitani, Shigeki
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Preventing thrombosis in a COVID-19 patient by combinatorial therapy with nafamostat and heparin during extracorporeal membrane oxygenation
T2  - Acute Medicine & Surgery
TI  - Preventing thrombosis in a COVID-19 patient by combinatorial therapy with nafamostat and heparin during extracorporeal membrane oxygenation
UR  - https://doi.org/10.1002/ams2.585
ID  - 7788136
ER  - 

TY  - JOUR
AB  - BACKGROUND AND OBJECTIVE: The aim of this study was to investigate the pattern of disinfectants use within outbreak of COVID-19 and estimate their adverse effects on the consumer's health. METHODS: In this descriptive-analytical study, 1090 participants were entered into the study without age and gender limitations. A researcher-made electronic checklist containing 43 questions was applied to collect data. The checklist included three sections: demographic characteristics (8 questions), disinfection of body and non-living surfaces (21 questions), and adverse effects of disinfectants on health (15 questions). RESULTS: 87% of participants used the incorrect proportions of water and alcohol to make this disinfectant available at home. The percentage of people with wrong proportion of sodium hypochlorite was 74.2%. Approximately 42% of participants experienced at least one disorder on their hands, feet, eyes, respiratory or gastrointestinal systems after sequential uses of disinfectants. The most common disorders among the participants were found to be skin dryness (76.3%), obsession (42.2%), skin itching (41.2%), coughing (41.1%), and eyes irritation (39.5%). The mean frequency of hand washing and hand disinfecting were 15.28 and 10.74 times per a day, respectively, and the clean-up in case of surfaces was 2.99 times a day. The frequency of hand washing and disinfecting in women group (16.4 and 11.2 times a day) were higher than in men (14.0 and 10.3 times a day) group. In addition, these self-care actions in married people (15.6 and 11.0 times a day) were higher compared to those in single people (14.0 and 10.6 times a day). CONCLUSION: Being unaware of participants with instruction for preparation and use disinfectants may harm their health. Therefore, it is suggested that the authorities provide the necessary training program for public through official media.
AD  - Department of Environmental Health Engineering, School of public health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. GRID: grid.412237.1. ISNI: 0000 0004 0385 452X
Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. GRID: grid.412237.1. ISNI: 0000 0004 0385 452X
Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. GRID: grid.412237.1. ISNI: 0000 0004 0385 452X
Infectious and Tropical Diseases Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. GRID: grid.412237.1. ISNI: 0000 0004 0385 452X
Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. GRID: grid.412237.1. ISNI: 0000 0004 0385 452X
Department of Environmental Health Engineering, School of Public Health, Iran University of Medical Sciences, Tehran, IR Iran. GRID: grid.411746.1. ISNI: 0000 0004 4911 7066
AN  - 33020721
AU  - Dindarloo, K.
AU  - Aghamolaei, T.
AU  - Ghanbarnejad, A.
AU  - Turki, H.
AU  - Hoseinvandtabar, S.
AU  - Pasalari, H.
AU  - Ghaffari, H. R.
C1  - 10/6/2020
C2  - PMC7527249
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s40201-020-00548-y
DP  - NLM
ET  - 2020/10/07
J2  - Journal of environmental health science & engineering
KW  - Covid-19
Disinfection
Health effects
Safety
LA  - eng
N1  - Dindarloo, Kavoos
Aghamolaei, Teamur
Ghanbarnejad, Amin
Turki, Habibollah
Hoseinvandtabar, Sommayeh
Pasalari, Hasan
Ghaffari, Hamid Reza
Orcid: 0000-0002-0029-1616
Journal Article
England
J Environ Health Sci Eng. 2020 Sep 30:1-10. doi: 10.1007/s40201-020-00548-y.
PY  - 2020
SN  - 2052-336X (Print)
SP  - 1-10
ST  - Pattern of disinfectants use and their adverse effects on the consumers after COVID-19 outbreak
T2  - Journal of environmental health science & engineering
TI  - Pattern of disinfectants use and their adverse effects on the consumers after COVID-19 outbreak
ID  - 7784999
ER  - 

TY  - JOUR
AB  - When looking for new antiviral compounds aimed to counteract the COVID-19, a disease caused by the recently identified novel coronavirus (SARS-CoV-2), the knowledge of the main viral proteins is fundamental. The major druggable targets of SARS-CoV-2 include 3-chymotrypsin-like protease (3CLpro), papain-like protease (PLpro), RNA-dependent 26 RNA polymerase, and spike (S) protein. Molecular docking studies have highlighted that quercetin, a natural polyphenol belonging to the flavonol class, inhibits 3CLpro, PLpro and S proteins. Biophysical technics have then very recently confirmed that quercetin is reasonably a potent inhibitor of 3CLpro. The likely antiviral properties of quercetin are anyway challenged by its very poor oral bioavailability profile and any attempt to overcome this limit should be welcome. A phospholipid complex of quercetin (Quercetin Phytosome�]) has been recently tested in humans to evaluate a possible improvement in oral bioavailability. After hydrolysis of the conjugated form (mainly glucuronide) of quercetin found in human plasma, the pharmacokinetics results have demonstrated an increased bioavailability rate by about 20-fold for total quercetin. It has been also observed that the presence of specific glucuronidase could yield free systemic quercetin in human body. Taking also into considerations its anti-inflammatory and thrombin-inhibitory actions, a bioavailable form of quercetin, like Quercetin Phytosome�], should be considered a possible candidate to clinically face COVID-19.
AD  - Scientific &amp; Research Department, Velleja Research, Milan, Italy - f.dipierro@vellejaresearch.com.
Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford, UK.
Department of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Pesaro-Urbino, Italy.
Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy.
Department of Molecular Pathology, Dow University of Health Sciences, Karachi, Pakistan.
Department of Obstetrics and Gynecology, Liaquat University of Medical &amp; Health Sciences, Jamshoro, Sindh, Pakistan.
Department of Pathology, Liaquat University of Medical &amp; Health Sciences, Jamshoro, Sindh, Pakistan.
Department of Medicine, Liaquat University of Medical &amp; Health Sciences, Jamshoro, Sindh, Pakistan.
AN  - 33016666
AU  - Di Pierro, F.
AU  - Khan, A.
AU  - Bertuccioli, A.
AU  - Maffioli, P.
AU  - Derosa, G.
AU  - Khan, S.
AU  - Khan, B. A.
AU  - Nigar, R.
AU  - Ujjan, I.
AU  - Devraian, B. R.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.23736/s1121-421x.20.02771-3
DP  - NLM
ET  - 2020/10/06
J2  - Minerva gastroenterologica e dietologica
LA  - eng
N1  - 1827-1642
Di Pierro, Francesco
Khan, Amjad
Bertuccioli, Alexander
Maffioli, Pamela
Derosa, Giuseppe
Khan, Saeed
Khan, Bilal A
Nigar, Roohi
Ujjan, Ikram
Devraian, Bikha R
Journal Article
Italy
Minerva Gastroenterol Dietol. 2020 Oct 5. doi: 10.23736/S1121-421X.20.02771-3.
PY  - 2020
SN  - 1121-421x
ST  - Quercetin Phytosome�] as a potential drug for Covid-19
T2  - Minerva gastroenterologica e dietologica
TI  - Quercetin Phytosome�] as a potential drug for Covid-19
ID  - 7785188
ER  - 

TY  - JOUR
AD  - Guangzhou Center for Disease Control and Prevention, 510440, Guangzhou, Guangdong, China.
Department of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, 510632, Guangzhou, Guangdong, China.
Department of Systems Biomedical Sciences, School of Medicine, Jinan University, 510632, Guangzhou, Guangdong, China.
GMU-GIBH Joint School of Life Sciences, Guangzhou Medical University, 511436, Guangzhou, Guangdong, China.
BGI-Shenzhen. Beishan Industrial Zone, 11th building, Yantian District, 518055, Shenzhen, Guangdong, China.
Department of Pathophysiology, Key Laboratory of National Administration of Traditional Chinese Medicine of the People's Republic of China, School of Medicine, Jinan University, 510632, Guangzhou, Guangdong, China.
Clinical Data Center, Guangdong General Hospital/Guangdong Academy of Medical Sciences, 510080, Guangzhou, Guangdong, China. lianghuiying@hotmail.com.
Department of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, 510632, Guangzhou, Guangdong, China. fanjun@jnu.edu.cn.
Guangzhou Center for Disease Control and Prevention, 510440, Guangzhou, Guangdong, China. yangzc@gzcdc.org.cn.
AN  - 33011738
AU  - Di, B.
AU  - Jia, H.
AU  - Luo, O. J.
AU  - Lin, F.
AU  - Li, K.
AU  - Zhang, Y.
AU  - Wang, H.
AU  - Liang, H.
AU  - Fan, J.
AU  - Yang, Z.
C1  - 10/6/2020
C2  - PMC7532335
DA  - Oct 3
DB  - PubMed
DO  - 10.1038/s41392-020-00333-1
DP  - NLM
ET  - 2020/10/05
IS  - 1
J2  - Signal transduction and targeted therapy
LA  - eng
N1  - 2059-3635
Di, Biao
Jia, Hongling
Luo, Oscar Junhong
Orcid: 0000-0002-1266-3069
Lin, Fangqin
Li, Kuibiao
Zhang, Yuanliang
Wang, Huadong
Liang, Huiying
Fan, Jun
Orcid: 0000-0001-6637-9891
Yang, Zhicong
Letter
Signal Transduct Target Ther. 2020 Oct 3;5(1):217. doi: 10.1038/s41392-020-00333-1.
PY  - 2020
SN  - 2095-9907 (Print)
2059-3635
SP  - 217
ST  - Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics
T2  - Signal transduction and targeted therapy
TI  - Identification and validation of predictive factors for progression to severe COVID-19 pneumonia by proteomics
VL  - 5
ID  - 7785658
ER  - 

TY  - JOUR
AB  - The Corona Virus Disease - 2019 (COVID-19) outbreak started in China in December 2019 and rapidly spread all over the world infecting more than 20 million people and causing more than 700,000 deaths. Overall mortality in COVID-19 is 3-4%(1) ; the mortality generally happens in patients with older age and comorbidities. No evidence-based treatment has been approved so far.(2) Outcomes of COVID-19 in Liver Transplant (LT) recipients are not well known at present. In a single center report from United States, Lee et al. reported overall mortality of 18.4% (7 of 38) in LT recipients; all patients who died had co-morbidities(3) . Polak et al. reported 15% mortality in 244 LT recipients in an internet-based survey of European countries.
AD  - Institute of Liver Transplantation & Regenerative Medicine, Medanta The Medicity, Gurugram, India.
AN  - 33021025
AU  - Dhampalwar, S.
AU  - Saigal, S.
AU  - Choudhary, N.
AU  - Saraf, N.
AU  - Bhangui, P.
AU  - Rastogi, A.
AU  - Thiagrajan, S.
AU  - Soin, A. S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/lt.25909
DP  - NLM
ET  - 2020/10/07
J2  - Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
KW  - Corona virus
Ldlt
SARS-CoV-2
LA  - eng
N1  - 1527-6473
Dhampalwar, Swapnil
Orcid: 0000-0003-1585-8467
Saigal, Sanjiv
Choudhary, Narendra
Orcid: 0000-0002-4387-0036
Saraf, Neeraj
Bhangui, Prashant
Orcid: 0000-0002-4839-5852
Rastogi, Amit
Thiagrajan, Srinivasan
Soin, Arvinder S
Journal Article
United States
Liver Transpl. 2020 Oct 5. doi: 10.1002/lt.25909.
PY  - 2020
SN  - 1527-6465
ST  - Outcomes of COVID-19 in living donor liver transplant (LDLT) recipients
T2  - Liver transplantation : official publication of American Association for Study of Liver Diseases and International Liver Transplantation Society
TI  - Outcomes of COVID-19 in living donor liver transplant (LDLT) recipients
ID  - 7784963
ER  - 

TY  - JOUR
AU  - Desai, Deven R.
AU  - Makridis, Christos
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Cybersecurity, data breach, input-output linkages, supply chain
PY  - 2020
ST  - Supply Chain Risks in Cybersecurity (preprint)
T2  - SSRN
TI  - Supply Chain Risks in Cybersecurity (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693544
ID  - 7788905
ER  - 

TY  - JOUR
AB  - BACKGROUND: Hand hygiene is crucial to avoid healthcare-associated infections and the transmission of COVID-19. Although the WHO has issued global hand hygiene recommendations for healthcare, adherence remains challenging. Considering social-cognitive theories such as the health action process approach (HAPA) can help to improve healthcare workers' adherence. This study aimed to observe adherence and to assess determinants in obstetric hospitals during and after the onset of the COVID-19 pandemic. METHODS: In all, 267 observations of behaviour were conducted in two German obstetric university hospitals over three time periods (pre-COVID-19 pandemic, heightened awareness, and strict precautions). In addition, 115 healthcare workers answered questionnaires regarding social-cognitive determinants of hand hygiene behaviour. Multiple regression and multiple mediation analyses were used to analyse associations. RESULTS: Adherence to hand hygiene recommendations increased from 47 per cent pre-COVID-19 pandemic to 95 per cent just before lockdown while simple measures against the pandemic were taken. Self-efficacy was associated with the intention to sanitise hands (β = .397, p  .001). Coping self-efficacy mediated the association of intention with hand hygiene adherence. CONCLUSIONS: Obstetric healthcare workers seem to adapt their hand hygiene behaviour to prevent infections facing the global COVID-19 pandemic. To further improve interventions, social-cognitive determinants should be considered, especially intention and (coping) self-efficacy.
AD  - Jacobs University Bremen gGmbH, Germany.
AN  - 33016518
AU  - Derksen, C.
AU  - Keller, F. M.
AU  - Lippke, S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/aphw.12240
DP  - NLM
ET  - 2020/10/06
J2  - Applied psychology. Health and well-being
KW  - Covid-19
hand hygiene behaviour
health action process approach
observations
obstetrics and gynaecology
social-cognitive determinants
LA  - eng
N1  - 1758-0854
Derksen, Christina
Orcid: 0000-0002-4663-1882
Keller, Franziska M
Orcid: 0000-0002-7728-9709
Lippke, Sonia
Orcid: 0000-0002-8272-0399
Project No. 01VSF18023/Innovation Fund of the The Federal Joint Committee (G-BA, the highest decision-making body of the joint self-government of physicians, dentists, psychotherapists, hospitals, and health insurance funds in Germany)/
Journal Article
England
Appl Psychol Health Well Being. 2020 Oct 5. doi: 10.1111/aphw.12240.
PY  - 2020
SN  - 1758-0854
ST  - Obstetric Healthcare Workers' Adherence to Hand Hygiene Recommendations during the COVID-19 Pandemic: Observations and Social-Cognitive Determinants
T2  - Applied psychology Health and well-being
TI  - Obstetric Healthcare Workers' Adherence to Hand Hygiene Recommendations during the COVID-19 Pandemic: Observations and Social-Cognitive Determinants
ID  - 7785209
ER  - 

TY  - JOUR
AB  - In this paper, I use administrative data to estimate the number of deaths, the number of infections, and mortality rates from COVID-19 in Lombardia, the hot spot of the disease in Italy and Europe. The information will assist policy makers in reaching correct decisions and the public in adopting appropriate behaviors. As the available data suffer from sample selection bias, I use partial identification to derive the above quantities. Partial identification combines assumptions with the data to deliver a set of admissible values or bounds. Stronger assumptions yield stronger conclusions but decrease the credibility of the inference. Therefore, I start with assumptions that are always satisfied, then I impose increasingly more restrictive assumptions. Using my preferred bounds, during March 2020 in Lombardia, there were between 10,000 and 18,500 more deaths than in previous years. The narrowest bounds of mortality rates from COVID-19 are between 0.1 and 7.5%, much smaller than the 17.5% discussed in earlier reports. This finding suggests that the case of Lombardia may not be as special as some argue.
AD  - Banca d'Italia, Economics and Statistics Department, Via Nazionale, Rome, 91 - 00184 Italy. GRID: grid.466503.2. ISNI: 0000 0001 2296 4343
AN  - 33013001
AU  - Depalo, D.
C1  - 10/6/2020
C2  - PMC7524382
DA  - Sep 29
DB  - PubMed
DO  - 10.1007/s00148-020-00801-6
DP  - NLM
ET  - 2020/10/06
J2  - Journal of population economics
KW  - Bounds
Covid-19
Mortality
LA  - eng
N1  - 1432-1475
Depalo, Domenico
Orcid: 0000-0001-7395-1286
Journal Article
J Popul Econ. 2020 Sep 29:1-22. doi: 10.1007/s00148-020-00801-6.
PY  - 2020
SN  - 0933-1433 (Print)
0933-1433
SP  - 1-22
ST  - True COVID-19 mortality rates from administrative data
T2  - Journal of population economics
TI  - True COVID-19 mortality rates from administrative data
ID  - 7785515
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19) pandemic has had a major impact on pediatric surgery. The infection is often asymptomatic and atypical in children, while overlapping presentations with other infectious diseases generate additional diagnostic challenges. The high probability of missed pediatric cases and the invasive nature of surgery generate great concern for widespread transmission in this setting. Current guidelines suggest that triage of cases should be made on a case-by-case basis by a multidisciplinary team of experts. Decision-making can be assisted by classifying cases as elective, urgent, or an emergency according to the risks of delaying their surgical management. A workflow diagram should ideally guide the management of all cases from admission to discharge. When surgery is necessary, all staff should use appropriate personal protective equipment, and high-risk practices, such as aerosol-generating tools or procedures, should be avoided if possible. Furthermore, carefully designed organizational protocols should be established to minimize transmission while ensuring the uninterrupted operation of pediatric surgery units. For example, surgical teams can be divided into small weekly rotating groups, and healthcare workers should be continuously monitored for COVID-19 symptoms. Additionally, team protocols in the operating room can optimize communication and improve adherence to personal protective equipment use. Isolated operating rooms, pediatric intensive care units, and surgical wards should be specifically designed for suspected or confirmed COVID-19 cases. Finally, transportation of patients should be minimal and follow designated short routes. All these measures can help mitigate the effects of the COVID-19 pandemic on pediatric surgery units.
AD  - Surgery Working Group, Society of Junior Doctors, Athens 15123, Greece.
First Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki 54622, Greece. tsoulfasg@gmail.com.
AN  - 33014718
AU  - Dedeilia, A.
AU  - Esagian, S. M.
AU  - Ziogas, I. A.
AU  - Giannis, D.
AU  - Katsaros, I.
AU  - Tsoulfas, G.
C1  - 10/6/2020
C2  - PMC7515751
DA  - Sep 19
DB  - PubMed
DO  - 10.5409/wjcp.v9.i2.7
DP  - NLM
ET  - 2020/10/06
IS  - 2
J2  - World journal of clinical pediatrics
KW  - Covid-19
Coronavirus
Emergency surgery
Pediatric surgery
Personal protective equipment
SARS-CoV-2
interests.
LA  - eng
N1  - 2219-2808
Dedeilia, Aikaterini
Esagian, Stepan M
Ziogas, Ioannis A
Giannis, Dimitrios
Katsaros, Ioannis
Tsoulfas, Georgios
Journal Article
Review
World J Clin Pediatr. 2020 Sep 19;9(2):7-16. doi: 10.5409/wjcp.v9.i2.7. eCollection 2020 Sep 19.
PY  - 2020
SN  - 2219-2808 (Print)
2219-2808
SP  - 7-16
ST  - Pediatric surgery during the COVID-19 pandemic
T2  - World journal of clinical pediatrics
TI  - Pediatric surgery during the COVID-19 pandemic
VL  - 9
ID  - 7785369
ER  - 

TY  - JOUR
AB  - To rapidly evaluate the safety and efficacy of COVID-19 vaccine candidates, prioritizing vaccine trial sites in areas with high expected disease incidence can speed endpoint accrual and shorten trial duration. Mathematical and statistical forecast models can inform the process of site selection, integrating available data sources and facilitating comparisons across locations. We recommend the use of ensemble forecast modeling - combining projections from independent modeling groups - to guide investigators identifying suitable sites for COVID-19 vaccine efficacy trials. We describe an appropriate structure for this process, including minimum requirements, suggested output, and a user-friendly tool for displaying results. Importantly, we advise that this process be repeated regularly throughout the trial, to inform decisions about enrolling new participants at existing sites with waning incidence versus adding entirely new sites. These types of data-driven models can support the implementation of flexible efficacy trials tailored to the outbreak setting.
AD  - Department of Biostatistics, University of Florida, Gainesville, FL, United States. Electronic address: nataliedean@ufl.edu.
Laboratory for the Modeling of Biological and Socio-technical Systems, Northeastern University, Boston, MA, United States.
Department of Biostatistics, University of Florida, Gainesville, FL, United States.
Department of Biology, University of Florida, Gainesville, FL, United States.
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States.
Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Biostatistics, University of Washington, Seattle, WA, United States.
AN  - 33012602
AU  - Dean, N. E.
AU  - Pastore, Y. Piontti A.
AU  - Madewell, Z. J.
AU  - Cummings, D. A. T.
AU  - Hitchings, M. D. T.
AU  - Joshi, K.
AU  - Kahn, R.
AU  - Vespignani, A.
AU  - Halloran, M. E.
AU  - Longini, I. M., Jr.
C1  - 10/6/2020
DA  - Sep 15
DB  - PubMed
DO  - 10.1016/j.vaccine.2020.09.031
DP  - NLM
ET  - 2020/10/06
J2  - Vaccine
KW  - Efficacy trial
Ensemble modeling
Forecast model
Trial planning
competing financial interests or personal relationships that could have appeared to
influence the work reported in this paper.
LA  - eng
N1  - 1873-2518
Dean, Natalie E
Pastore Y Piontti, Ana
Madewell, Zachary J
Cummings, Derek A T
Hitchings, Matthew D T
Joshi, Keya
Kahn, Rebecca
Vespignani, Alessandro
Halloran, M Elizabeth
Longini, Ira M Jr
Journal Article
Netherlands
Vaccine. 2020 Sep 15:S0264-410X(20)31191-9. doi: 10.1016/j.vaccine.2020.09.031.
PY  - 2020
SN  - 0264-410x
ST  - Ensemble forecast modeling for the design of COVID-19 vaccine efficacy trials
T2  - Vaccine
TI  - Ensemble forecast modeling for the design of COVID-19 vaccine efficacy trials
ID  - 7785567
ER  - 

TY  - JOUR
AN  - 2007887231
AU  - de Fiore, R.
C1  - 10/6/2020
DA  - September
DB  - Embase
DO  - http://dx.doi.org/10.1701/3421.34072
DP  - Ovid Technologies
IS  - 9
KW  - coronavirus disease 2019
human
short survey
LA  - Italian
M3  - Short Survey
PY  - 2020
SN  - 0034-1193
2038-1840
SP  - 555-556
ST  - Should the air conditioner be sanitized so as not to risk for COVID-19?. [Italian]
T2  - Recenti Progressi in Medicina
TI  - Should the air conditioner be sanitized so as not to risk for COVID-19?. [Italian]
TT  - Il condizionatore va sanificato per non rischiare CoViD-19?.
UR  - https://www.recentiprogressi.it/r.php?v=3421&a=34072&l=341543&f=allegati/03421_2020_09/fulltext/RPM_920.16_Dottore%20ma.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007887231
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:32914787&id=10.1701%2F3421.34072&issn=0034-1193&isbn=&volume=111&issue=9&spage=555&pages=555-556&date=2020&title=Recenti+Progressi+in+Medicina&atitle=Il+condizionatore+va+sanificato+per+non+rischiare+CoViD-19%3F&aulast=de+Fiore&pid=%3Cauthor%3Ede+Fiore+R.%3C%2Fauthor%3E&%3CAN%3E2007887231%3C%2FAN%3E&%3CDT%3EShort+Survey%3C%2FDT%3E
VL  - 111
ID  - 7782847
ER  - 

TY  - JOUR
AD  - Head of the Pediatric Surgeri Service. Gregorio Marañ�Qn Maternal and Child Hospital. Madrid (Spain). President of the Spanish Society of Pediatric Surgery.
AN  - 33016652
AU  - de Agust�Tn Asensio, J. C.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
LA  - eng
spa
N1  - 2445-2807
de Agust�Tn Asensio, J C
Editorial
Spain
Cir Pediatr. 2020 Oct 1;33(4):153.
OP  - La cirug�Ta pedi֙trica durante la pandemia por SARS-CoV-2.
PY  - 2020
SN  - 0214-1221
SP  - 153
ST  - Pediatric Surgery during the SARS-CoV-2 pandemic
T2  - Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica
TI  - Pediatric Surgery during the SARS-CoV-2 pandemic
VL  - 33
ID  - 7785190
ER  - 

TY  - JOUR
AD  - Department of Palliative Care and Psycho-oncology, Tata Medical Centre, New Town Rajarhat, Kolkata, India.
MRC Clinical Trials Unit, Institute of Clinical Trials and Methodology, University College London, UK.
Department of Medical Administration, Tata Medical Centre, New Town Rajarhat, Kolkata, India.
Department of Microbiology, Tata Medical Centre, New Town Rajarhat, Kolkata, India.
Queen's University, Kingston, Ontario, Canada.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
AN  - 33017180
AU  - Datta, S. S.
AU  - Mukherjee, A.
AU  - Ghose, S.
AU  - Bhattacharya, S.
AU  - Gyawali, B.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1200/go.20.00470
DP  - NLM
ET  - 2020/10/06
J2  - JCO global oncology
LA  - eng
N1  - 2687-8941
Datta, Soumitra S
Orcid: 0000-0003-1674-5093
Mukherjee, Arnab
Orcid: 0000-0002-6325-7116
Ghose, Soumita
Orcid: 0000-0003-0084-1283
Bhattacharya, Sanjay
Orcid: 0000-0003-4139-1039
Gyawali, Bishal
Orcid: 0000-0001-7444-8594
Journal Article
United States
JCO Glob Oncol. 2020 Oct;6:1490-1493. doi: 10.1200/GO.20.00470.
PY  - 2020
SN  - 2687-8941
SP  - 1490-1493
ST  - Addressing the Mental Health Challenges of Cancer Care Workers in LMICs During the Time of the COVID-19 Pandemic
T2  - JCO global oncology
TI  - Addressing the Mental Health Challenges of Cancer Care Workers in LMICs During the Time of the COVID-19 Pandemic
VL  - 6
ID  - 7785155
ER  - 

TY  - JOUR
AB  - This paper on the SARS-CoV-2 crisis in India examines the emergence of ”COVtech�?as a range of public sector-led technologies of surveillance, management and containment of the virus. COVtech lends itself to examination of what Simondon calls ”concretisation�?of technical objects. We argue that COVtech initiatives have different modes of existence in India–first as the redeployment of existing technologies assembled across urban, regional and federal scales of governance; second, as current technologies curated within translocally situated networks which are mobilised to provide relief and support to vulnerable groups locked out/in Indian cities. We conclude by proposing that a progressive mode of existence of COVtech rests not with the ‘what�?and ‘where�?of the disease monitored by the apps, maps and War rooms of the State, but in addressing the ‘who�?and ‘how�?of its impacts mobilised by civil society and non-state actors. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
AD  - Faculty of Social and Historical Sciences, University College London, London, United Kingdom
Independent Scholar, India
Political Science, Jawaharlal Nehru University, New Delhi, India
AU  - Datta, A.
AU  - Aditi, A.
AU  - Ghoshal, A.
AU  - Thomas, A.
AU  - Mishra, Y.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1080/02723638.2020.1807165
10.1177/2043820620929797, , In; Datta, A., Geography Directions (2020) Survival infrastructures under COVID-19, , https://blog.geographydirections.com/2020/05/13/survival-infrastructures-under-covid-19/, Retrieved June 6, 2020, from; Dutta, A., How Centre is using smart cities project to monitor Covid-19 hot spots (2020) Hindustan Times, , https://www.hindustantimes.com/india-news/how-centre-is-using-smart-cities-project-to-monitor-covid-19-hot-spots/story-qxu3fj0H6eeT5qvIqgUSgI.html, April, 7, Retrieved from; Engelmann, L., Henderson, J., Lynteris, C., (2019) Plague and the city, , Routledge, &, (Eds.). (,. London; Evans, N.H.A., (2019) The disease map and the city: Desire and imitation in the Bombay Plague 1896-1914, , Engelmann L., Henderson J., C, (eds),. Lynteris (Eds.), Plague and the city,  (116�?38). London: Routledge; (2020) Non virus deaths, , https://thejeshgn.com/projects/covid19-india/non-virus-deaths/, Retrieved June 6, 2020, from; Jaiswal, P., 10 UP cities fight Covid-19 war ‘smartly�? and how! (2020) Hindustan Times, , https://www.hindustantimes.com/lucknow/10-up-cities-fight-covid-19-war-smartly-and-how/story-Ci5zysN41kFQvP2nRBqvwO.html, April, 24, Retrieved from; Kitchin, R., Using digital technologies to tackle the spread of the coronavirus: Panacea or folly? (2020) The Programmable City Working Paper, 44; Koch, T., (2011) Disease maps: Epidemics on the ground, , University of Chicago Press; Krishnan, B.V., (2019), February 8). 24% of Indians have a smartphone, says Pew study., The Hindu,. Retrieved from https://www.thehindu.com/news/national/24-pc-of-indians-have-a-smartphone/article26212864.ece; https://mwsn.in/resistancemap/, Retrieved from; (2020), https://innovate.mygov.in/aarogyasetu-bug-bounty/#skip, Retrieved from; Patel, T., Bhubaneswar start-up’s new delivery service for the elderly helps 600+ in 4 weeks (2020) The Better India, , https://www.thebetterindia.com/224625/odisha-coronavirus-covid-19-cases-bhubaneswar-lockdown-senior-citizens-helpline-delivery-service-tan42/, April, 24, Retrieved from; Patra, I., Aarogya Setu app is now open source: What does it mean? (2020) The Hindu, , https://www.thehindu.com/sci-tech/technology/aarogya-setu-app-is-now-open-source-what-does-it-mean/article31689459.ece, May, 28, Retrieved from; How Bengaluru’s war room plays its role in fighting coronavirus (2020) Video File, , https://www.youtube.com/watch?v=Pa06ICyVRnM, April, 13, Retrieved from; Shanthin, S., How India’s rising startups Swung into action from the word go (2020) Inc42, , https://inc42.com/features/startups-vs-covid19-how-indias-rising-startups-swung-into-action-from-the-word-go/, April, 11, Retrieved from; Simondon, G., (2017) On the mode of existence of technical objects, , Univocal; Tripathi, R., MHA dilutes provision on use of Aarogya Setu app (2020) The Economic Times, , https://economictimes.indiatimes.com/news/politics-and-nation/aarogya-setu-not-mandatory-for-nris/articleshow/75983344.cms?utm_source=contentofinterest&utm_medium=text&utm_campaign=cppst, May, 26, Retrieved from
J2  - Urban Geogr.
KW  - disease surveillance
smart cities
India
SARS-CoV-2
technology
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Datta, A.; Faculty of Social and Historical Sciences, University College LondonUnited Kingdom; email: a.datta@ucl.ac.uk
PY  - 2020
SN  - 02723638 (ISSN)
ST  - Apps, maps and war rooms: on the modes of existence of “COVtech�?in India
T2  - Urban Geography
TI  - Apps, maps and war rooms: on the modes of existence of “COVtech�?in India
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091724600&doi=10.1080%2f02723638.2020.1807165&partnerID=40&md5=6a486de67a6f72f9e0f7d7d9ffa86b2f
ID  - 7783321
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) is a new infectious disease that spreads very rapidly and therefore, WHO has declared it as a global pandemic disease. The main clinical symptoms found in COVID-19 patients are cough and fever; however, in some cases, diarrhea can be one of the early symptoms. The present case report describes a patient who came with a complaint of diarrhea without fever and she was later confirmed to be positive for COVID-19 during hospitalization. The presence of unspecified initial symptoms calls for greater vigilance from health workers in establishing diagnosis patients with COVID-19.
AD  - Department of Internal Medicine, Fatmawati Central General Hospital, Jakarta, Indonesia. nikkodarnindro@gmail.com.
AN  - 33020339
AU  - Darnindro, N.
AU  - Nurdewati, L.
AU  - Manurung, A.
AU  - Mokoagow, M. I.
AU  - Nasarudin, J.
AU  - Wardoyo, E. Y.
AU  - Sari, A. P.
AU  - Djojo, A. Y.
AU  - Iskandar, M.
AU  - Adji, G.
AU  - Epriliawati, M.
AU  - Mauleti, I.
AU  - Mulyana, E.
AU  - Harahap, A.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
Indonesia
SARS-Cov-2
diarrhea
early manifestations
LA  - eng
N1  - Darnindro, Nikko
Nurdewati, Linda
Manurung, Annela
Mokoagow, M Ikhsan
Nasarudin, Jerry
Wardoyo, Elisabeth Yasmine
Sari, Anggraini Permata
Djojo, Aryan Yohanes
Iskandar, Martha
Adji, Giri
Epriliawati, Marina
Mauleti, Ifael
Mulyana, Edi
Harahap, Arnold
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):283-289.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 283-289
ST  - Diarrhea as an Early and Predominant Manifestation of Coronavirus Disease 2019 (COVID-19): A Case Report
T2  - Acta medica Indonesiana
TI  - Diarrhea as an Early and Predominant Manifestation of Coronavirus Disease 2019 (COVID-19): A Case Report
VL  - 52
ID  - 7785031
ER  - 

TY  - JOUR
AB  - BACKGROUND: The availability of a COVID-19 vaccine is being heralded as the solution to control the current COVID-19 pandemic, reduce the number of infections and deaths and facilitate resumption of our previous way of life. OBJECTIVE: The aim of this article is to provide a framework for primary care of what will be needed to optimise COVID-19 vaccine confidence and uptake in Australia once the vaccine prioritisation schedule and key target groups are known. DISCUSSION: While a number of vaccines are currently under development, with at least seven undergoing phase III trials (28 August 2020), it is hoped that an effective COVID-19 vaccine will become available to the public in 2021. Ensuring public confidence in vaccine safety and effectiveness will be crucial to facilitate uptake. General practitioners are at the forefront of public health, and one of the most trusted sources for patients. In this article, the authors discuss the expedited vaccine development process for COVID-19 vaccines; the likely vaccine prioritisation schedule and anticipated key target groups; the behavioural and social drivers of vaccination acceptance, including the work required to facilitate this; and the implications for general practice.
AD  - MBBS, PhD, FRACP, Associate Professor and David Bickart Clinician Scientist Fellow, Department of Paediatrics, The University of Melbourne, Vic; Group Leader, Vaccine Uptake Group, Murdoch Children@s Research Institute, Vic; Paediatrician, Department of General Medicine, The Royal Children@s Hospital, Vic.
MAppSc, PhD, Research Fellow, Department of General Practice, Melbourne Medical School, University of Melbourne, Vic.
BSc (Hons), MBBS (Hons), CHIA, PhD, FRACGP, Associate Professor - General Practice, Melbourne Medical School, University of Melbourne, Vic.
PhD, Research Fellow, Vaccine Uptake Group, Murdoch Children@s Research Institute, Vic; Honorary Fellow, Department of Paediatrics, The University of Melbourne, Vic.
PhD, MPH, Dip Health Sci (Nursing), Professor, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, NSW; Visiting Professorial Fellow, National Centre for Immunisation Research and Surveillance, NSW.
AN  - 33015676
AU  - Danchin, M.
AU  - Biezen, R.
AU  - Manski-Nankervis, J. A.
AU  - Kaufman, J.
AU  - Leask, J.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.31128/ajgp-08-20-5559
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Australian journal of general practice
LA  - eng
N1  - 2208-7958
Danchin, Margie
Biezen, Ruby
Manski-Nankervis, Jo-Anne
Kaufman, Jessica
Leask, Julie
Journal Article
Australia
Aust J Gen Pract. 2020 Oct;49(10):625-629. doi: 10.31128/AJGP-08-20-5559.
PY  - 2020
SP  - 625-629
ST  - Preparing the public for COVID-19 vaccines: How can general practitioners build vaccine confidence and optimise uptake for themselves and their patients?
T2  - Australian journal of general practice
TI  - Preparing the public for COVID-19 vaccines: How can general practitioners build vaccine confidence and optimise uptake for themselves and their patients?
VL  - 49
ID  - 7785261
ER  - 

TY  - JOUR
AD  - MBBS, PhD, FRACP, Associate Professor and David Bickart Clinician Scientist Fellow, Department of Paediatrics, The University of Melbourne, Vic; Group Leader, Vaccine Uptake Group, Murdoch Children@s Research Institute, Vic; Paediatrician, Department of General Medicine, The Royal Children@s Hospital, Vic.
AN  - 33015675
AU  - Danchin, M.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.31128/AJGP-10-20-1234e
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Australian journal of general practice
LA  - eng
N1  - 2208-7958
Danchin, Margie
Journal Article
Australia
Aust J Gen Pract. 2020 Oct;49(10):621. doi: 10.31128/AJGP-10-20-1234e.
PY  - 2020
SP  - 621
ST  - Editorial: Vaccination during the COVID-19 pandemic
T2  - Australian journal of general practice
TI  - Editorial: Vaccination during the COVID-19 pandemic
VL  - 49
ID  - 7785262
ER  - 

TY  - JOUR
AD  - Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, , Spedali Civili Hospital, University of Brescia, Brescia, Italy - alberto.dallavolta@gmail.com.
Medical Oncology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, , Spedali Civili Hospital, University of Brescia, Brescia, Italy.
Urology, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, Spedali Civili Hospital, University of Brescia, Brescia, Italy.
AN  - 33016032
AU  - Dalla Volta, A.
AU  - Valcamonico, F.
AU  - Zamboni, S.
AU  - Ferrari, V. D.
AU  - Grisanti, S.
AU  - Simeone, C.
AU  - Berruti, A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.23736/s0393-2249.20.04021-7
DP  - NLM
ET  - 2020/10/06
J2  - Minerva urologica e nefrologica = The Italian journal of urology and nephrology
LA  - eng
N1  - 1827-1758
Dalla Volta, Alberto
Valcamonico, Francesca
Zamboni, Stefania
Ferrari, Vittorio D
Grisanti, Salvatore
Simeone, Claudio
Berruti, Alfredo
Journal Article
Italy
Minerva Urol Nefrol. 2020 Oct 5. doi: 10.23736/S0393-2249.20.04021-7.
PY  - 2020
SN  - 0393-2249
ST  - Is androgen deprivation therapy protective against SARS-CoV-2 infection and related complications in prostate cancer patients?
T2  - Minerva urologica e nefrologica = Italian journal of urology and nephrology
TI  - Is androgen deprivation therapy protective against SARS-CoV-2 infection and related complications in prostate cancer patients?
ID  - 7785229
ER  - 

TY  - JOUR
AB  - OBJECTIVE: The present comprehensive review aims to show the full extent of what is known to date and provide a more thorough view on the effects of SARS-CoV2 in pregnancy. METHODS: Between March 29 and May, 2020, the words COVID-19, SARS-CoV2, COVID-19 and pregnancy, SARS-CoV2 and pregnancy, and SARS and pregnancy were searched in the PubMed and Google Scholar databases; the guidelines from well-known societies and institutions (Royal College of Obstetricians and Gynaecologists [RCOG], American College of Obstetricians and Gynecologists [ACOG], International Society of Ultrasound in Obstetrics &amp; Gynecology [ISUOG], Centers for Disease Control and Prevention [CDC], International Federation of Gynecology and Obstetrics [FIGO]) were also included. CONCLUSION: The COVID-19 outbreak resulted in a pandemic with &gt; 3.3 million cases and 230 thousand deaths until May 2nd. It is caused by the SARS-CoV2 virus and may lead to severe pulmonary infection and multi-organ failure. Past experiences show that unique characteristics in pregnancy make pregnant women more susceptible to complications from viral infections. Yet, this has not been reported with this new virus. There are risk factors that seem to increase morbidity in pregnancy, such as obesity (body mass index [BMI] &gt; 35), asthma and cardiovascular disease. Current reports describe an increased rate of preterm birth and C-section. Vertical transmission is still a possibility, due to a few reported cases of neonatal positive real-time polymerase chain reaction (RT-PCR) in nasal swab, amniotic fluid, and positive immunoglobulin M (IgM) in neonatal blood. Treatments must be weighed in with caution due to the lack of quality trials that prove their effectiveness and safety during pregnancy. Medical staff must use personal protective equipment in handling SARS-CoV2 suspected or positive patients and be alert for respiratory decompensations.
AU  - Czeresnia, Ricardo Mamber
AU  - Trad, Ayssa Teles Abrao
AU  - Britto, Ingrid Schwach Werneck
AU  - Negrini, Romulo
AU  - Nomura, Marcelo Lu�Ts
AU  - Pires, Pedro
AU  - Costa, Fabricio da Silva
AU  - Nomura, Roseli Mieko Yamamoto
AU  - Ruano, Rodrigo
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 9
LA  - en
PY  - 2020
SP  - 562-568
ST  - SARS-CoV-2 e gestação: uma revisão dos fatos
T2  - Rev Bras Ginecol Obstet
TI  - SARS-CoV-2 e gestação: uma revisão dos fatos
TT  - SARS-CoV-2 and Pregnancy: A Review of the Facts.
UR  - https://dx.doi.org/10.1055/s-0040-1715137
VL  - 42
ID  - 7788589
ER  - 

TY  - JOUR
AB  - Urgent responses to the COVID-19 pandemic depend on increased collaboration and sharing of data, models, and resources among scientists and researchers In many scientific fields and disciplines, institutional norms treat data, models, and resources as proprietary, emphasizing competition among scientists and researchers locally and internationally Concurrently, long-standing norms of open data and collaboration exist in some scientific fields and have accelerated within the last two decades In both cases?where the institutional arrangements are ready to accelerate for the needed collaboration in a pandemic and where they run counter to what is needed?the rules of the game are ?on the table? for institutional-level renegotiation These challenges to the negotiated order in science are important, difficult to study, and highly consequential The COVID-19 pandemic offers something of a natural experiment to study these dynamics Preliminary findings highlight: the chilling effect of politics where open sharing could be expected to accelerate;the surprisingly conservative nature of contests and prizes;open questions around whether collaboration will persist following an inflection point in the pandemic;and the strong potential for launching and sustaining pre-competitive initiatives
AU  - Cutcher-Gershenfeld, Joel
AU  - Baker, Karen S.
AU  - Berente, Nicholas
AU  - Berkman, Paul Arthur
AU  - Canavan, Pat
AU  - Feltus, F. Alex
AU  - Garmulewicz, Alysia
AU  - Hutchins, Ron
AU  - King, John Leslie
AU  - Kirkpatrick, Christine
AU  - Lenhardt, Chris
AU  - Lewis, Spencer
AU  - Maffe, Michael
AU  - Mittleman, Barbara
AU  - Sampath, Rajesh
AU  - Shin, Namchul
AU  - Stall, Shelley
AU  - Winter, Susan
AU  - Veazey, Pips
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Negotiated Sharing of Pandemic Data, Models, and Resources
T2  - Negotiation Journal
TI  - Negotiated Sharing of Pandemic Data, Models, and Resources
UR  - https://doi.org/10.1111/nejo.12340
ID  - 7788298
ER  - 

TY  - JOUR
AB  - OBJECTIVES: To analyse enrolment to interventional trials during the first wave of the COVID-19 pandemic in England and describe the barriers to successful recruitment in the circumstance of a further wave or future pandemics. DESIGN: We analysed registered interventional COVID-19 trial data and concurrently did a prospective observational study of hospitalised patients with COVID-19 who were being assessed for eligibility to one of the RECOVERY, C19-ACS or SIMPLE trials. SETTING: Interventional COVID-19 trial data were analysed from the clinicaltrials.gov and International Standard Randomized Controlled Trial Number databases on 12 July 2020. The patient cohort was taken from five centres in a respiratory National Institute for Health Research network. Population and modelling data were taken from published reports from the UK government and Medical Research Council Biostatistics Unit. PARTICIPANTS: 2082 consecutive admitted patients with laboratory-confirmed SARS-CoV-2 infection from 27 March 2020 were included. MAIN OUTCOME MEASURES: Proportions enrolled, and reasons for exclusion from the aforementioned trials. Comparisons of trial recruitment targets with estimated feasible recruitment numbers. RESULTS: Analysis of trial registration data for COVID-19 treatment studies enrolling in England showed that by 12 July 2020, 29�?42 participants were needed. In the observational study, 430 (20.7%) proceeded to randomisation. 82 (3.9%) declined participation, 699 (33.6%) were excluded on clinical grounds, 363 (17.4%) were medically fit for discharge and 153 (7.3%) were receiving palliative care. With 111�?37 people hospitalised with COVID-19 in England by 12 July 2020, we determine that 22�?85 people were potentially suitable for trial enrolment. We estimate a UK hospitalisation rate of 2.38%, and that another 1.25 million infections would be required to meet recruitment targets of ongoing trials. CONCLUSIONS: Feasible recruitment rates, study design and proliferation of trials can limit the number, and size, that will successfully complete recruitment. We consider that fewer, more appropriately designed trials, prioritising cooperation between centres would maximise productivity in a further wave.
AD  - Department of Clinical Neurosciences, Cambridge University, Cambridge, UK.
Harvard Medical School, Harvard University, Boston, Massachusetts, USA.
Division of Infection, University College London Hospital NHS Trust, London, UK.
Cancer Research UK Urological Malignancies Programme, Department of Oncology, University of Cambridge, Cambridge, UK.
Department of Cardiology, Hammersmith Hospitals NHS Trust, London, UK.
Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne, UK.
Department of Infection and Inflammation Research, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK.
MRC Clinical Trials Unit, University College London, London, UK.
Institute for Global Health, University College London, London, United Kingdom.
Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, UK.
Department of Respiratory Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Centre for Rheumatic Diseases, Kings College London, London, UK.
Department of Infectious Diseases, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Research and Development, North Tees Hospital, Stockton-on-Tees, UK.
National Heart and Lung Institute, Imperial College London, London, UK.
Department of Cardiology, St Marys Hospital, Imperial College Healthcare NHS Trust, London, UK.
Cambridge Urology Translational Research and Clinical Trials Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
School of Clinical Medicine, Office for Translational Research, University of Cambridge, Cambridge, UK.
Department of Respiratory Medicine, North Tees Hospital, Stockton-on-Tees, UK.
Division of Pathology, University College London Hospital NHS Trust, London, United Kingdom.
University of Cambridge, Cambridge, UK.
Cambridge Institute of Therapeutic Immunology and Infectious Disease, University of Cambridge, Cambridge, UK.
NHS Blood and Transplant, Cambridge, UK.
Department of Medicine, University of Cambridge, Cambridge, UK.
MRC Biostatistics Unit, University of Cambridge School of Clinical Medicine, Cambridge Institute of Public Health, Cambridge, United Kingdom.
Department of Surgery, University of Cambridge, Cambridge, UK.
Department of Medicine, University of Cambridge, Cambridge, UK mrt34@medschl.cam.ac.uk.
NIHR Respiratory Translational Research Collaboration, Cambridge, UK.
AN  - 33020111
AU  - Cunniffe, N. G.
AU  - Gunter, S. J.
AU  - Brown, M.
AU  - Burge, S. W.
AU  - Coyle, C.
AU  - De Soyza, A.
AU  - Dymond, T.
AU  - Esmail, H.
AU  - Francis, D. P.
AU  - Galloway, J.
AU  - Galloway, J. B.
AU  - Gkrania-Klotsas, E.
AU  - Greenaway, J.
AU  - Katritsis, G.
AU  - Kanagaratnam, P.
AU  - Knolle, M. D.
AU  - Leonard, K.
AU  - McIntyre, Z. C.
AU  - Prudon, B.
AU  - Rampling, T.
AU  - Torok, M. E.
AU  - Warne, B.
AU  - Yates, M.
AU  - Matheson, N. J.
AU  - Su, L.
AU  - Villar, S.
AU  - Stewart, G. D.
AU  - Toshner, M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/bmjopen-2020-044566
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - BMJ open
KW  - Covid-19
clinical trials
infectious diseases
LA  - eng
N1  - 2044-6055
Cunniffe, Nick G
Orcid: 0000-0002-7562-2838
Gunter, Simon J
Orcid: 0000-0001-7125-9296
Brown, Michael
Burge, Sarah W
Coyle, Clare
De Soyza, Anthony
Dymond, Tom
Esmail, Hanif
Francis, Darrel P
Galloway, Jacqui
Galloway, James B
Orcid: 0000-0002-1230-2781
Gkrania-Klotsas, Effrossyni
Greenaway, Jane
Katritsis, George
Kanagaratnam, Prapa
Knolle, Martin D
Leonard, Kelly
McIntyre, Zoe C
Prudon, Ben
Rampling, Tommy
Torok, Mili Estee
Orcid: 0000-0001-9098-8590
Warne, Ben
Yates, Mark
Matheson, Nicholas J
Su, Li
Villar, Sofia
Stewart, Grant D
Orcid: 0000-0003-3188-9140
Toshner, Mark
Journal Article
England
BMJ Open. 2020 Oct 5;10(10):e044566. doi: 10.1136/bmjopen-2020-044566.
PY  - 2020
SN  - 2044-6055
SP  - e044566
ST  - How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis
T2  - BMJ open
TI  - How achievable are COVID-19 clinical trial recruitment targets? A UK observational cohort study and trials registry analysis
VL  - 10
ID  - 7785052
ER  - 

TY  - JOUR
AB  - To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health Organization (WHO) in February 2020, has caused millions of infections and hundreds of thousands of deaths. Despite the scientific community efforts, there are currently no approved therapies for treating this coronavirus infection. The process of new drug development is expensive and time-consuming, so that drug repurposing may be the ideal solution to fight the pandemic. In this paper, we selected the proteins encoded by SARS-CoV-2 and using homology modeling we identified the high-quality model of proteins. A structure-based pharmacophore modeling study was performed to identify the pharmacophore features for each target. The pharmacophore models were then used to perform a virtual screening against the DrugBank library (investigational, approved and experimental drugs). Potential inhibitors were identified for each target using XP docking and induced fit docking. MM-GBSA was also performed to better prioritize potential inhibitors. This study will provide new important comprehension of the crucial binding hot spots usable for further studies on COVID-19. Our results can be used to guide supervised virtual screening of large commercially available libraries. © 2020 by the authors.
AD  - Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, Palermo, 90123, Italy
Dipartimento di Scienze Chimiche, Biologiche, Farmaceutiche ed Ambientali, Università di Messina, Viale Annunziata, Messina, 98168, Italy
Drug Discovery Unit, Fondazione Ri.MED, Palermo, 90133, Italy
AU  - Culletta, G.
AU  - Gulotta, M. R.
AU  - Perricone, U.
AU  - Zappalà, M.
AU  - Almerico, A. M.
AU  - Tutone, M.
C1  - 10/6/2020
C7  - 77
DB  - Scopus
DO  - 10.3390/COMPUTATION8030077
IS  - 3
J2  - Computation
KW  - Computational chemistry
COVID-19
Docking
MM-GBSA
Pharmacophore
SARS-CoV-2
Structure-based
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Tutone, M.; Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF), Università degli Studi di Palermo, Via Archirafi 32, Italy; email: marco.tutone@unipa.it
Funding text 1: Regional Assessorship of Productive Activities-Department of Productive Activities, funds: FSC 2014/2020. Project name: Computational Molecular Design e Screening-CheMISt-CUPG77B17000110001, Scientific Research within the "Patto per il sud" of the Sicily Region.
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A case study on PPAR alpha (2017) ChemMedChem, 12, pp. 1399-1407; Almerico, A.M., Tutone, M., Lauria, A., Receptor-guided 3D-QSAR approach for the discovery of c-kit tyrosine kinase inhibitors (2012) J. Mol. Model., 18, pp. 2885-2895; Almerico, A.M., Tutone, M., Pantano, L., Lauria, A., Molecular dynamics studies on Mdm2 complexes: An analysis of the inhibitor influence (2012) Biochem. Biophys. Res. Commun., 424, pp. 341-347; Genheden, S., Ryde, U., The MM/PBSA and MM/GBSA methods to estimate ligand-binding affinities (2015) Expert Opin. Drug Discov., 10, pp. 449-461; Tutone, M., Pibiri, I., Lentini, L., Pace, A., Almerico, A.M., Deciphering the Nonsense Readthrough Mechanism of Action of Ataluren: An in Silico Compared Study (2019) ACS Med. Chem. Lett., 10, pp. 522-527; Tutone, M., Virzì, A., Almerico, A.M., Reverse screening on indicaxanthin from Opuntia ficus-indica as natural chemoactive and chemopreventive agent (2018) J. Theor. Biol., 455, pp. 147-160; Hou, T., Yu, R., Molecular dynamics and free energy studies on the wild-type and double mutant HIV-1 protease complexed with amprenavir and two amprenavir-related inhibitors: Mechanism for binding and drug resistance (2007) J. Med. Chem., 50, pp. 1177-1188; Massova, I., Kollman, P.A., Combined molecular mechanical and continuum solvent approach (MM-PBSA/GBSA) to predict ligand binding (2000) Perspect. Drug Discov., 18, pp. 113-135; Wang, J., Morin, P., Wang, W., Kollman, P.A., Use of MM-PBSA in Reproducing the Binding Free Energies to HIV-1 RT of TIBO Derivatives and Predicting the Binding Mode to HIV-1 RT of Efavirenz by Docking and MM-PBSA (2001) J. Am. Chem. Soc., 123, pp. 5221-5230; Khan, S.A., Zia, K., Ashraf, S., Uddin, R., Ul-Haq, Z., Identification of chymotrypsin-like protease inhibitors of SARS-CoV-2 via integrated computational approach (2020) J. Biomol. Struct. Dyn., pp. 1-10; Arya, R., Das, A., Prashar, V., Kumar, M., Potential inhibitors against papain-like protease of novel coronavirus (SARS-CoV-2) from FDA approved drugs (2020) Chemrxiv. Org.; Gil, C., Ginex, T., Maestro, I., Nozal, V., Barrado-Gil, L., Cuesta-Geijo, M.A., Urquiza, J., Campillo, N.E., COVID-19: Drug targets and potential treatments (2020) J. Med. Chem.; Xu, X., Lou, Z., Ma, Y., Chen, X., Yang, Z., Tong, X., Zhao, Q., Bartlam, M., Crystal Structure of the C-Terminal Cytoplasmic Domain of Non-Structural Protein 4 from Mouse Hepatitis Virus A59 (2009) PLoS ONE., 4; Sutton, G., Fry, E., Carter, L., Sainsbury, S., Walter, T., Nettleship, J., Berrow, N., Davidson, A., The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights (2004) Structure, 12, pp. 341-353
PY  - 2020
SN  - 20793197 (ISSN)
ST  - Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach
T2  - Computation
TI  - Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091718268&doi=10.3390%2fCOMPUTATION8030077&partnerID=40&md5=32684547a5a43926192372e7f3df4c12
VL  - 8
ID  - 7783210
ER  - 

TY  - JOUR
AU  - Crane, Andrew
AU  - Matten, Dirk
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - COVID-19 and the future of CSR research
T2  - Journal of Management Studies
TI  - COVID-19 and the future of CSR research
UR  - https://doi.org/10.1111/joms.12642
ID  - 7788289
ER  - 

TY  - JOUR
AD  - Emergency Department, Fondazione Policlinico Universitario A. Gemelli, IRCCS, Rome, Italy.
Department of Internal Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Università Cattolica del Sacro Cuore, Rome, Italy.
AN  - 33012104
AU  - Covino, M.
AU  - De Matteis, G.
AU  - Franceschi, F.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/ggi.14020
DP  - NLM
ET  - 2020/10/05
J2  - Geriatrics & gerontology international
LA  - eng
N1  - 1447-0594
Covino, Marcello
Orcid: 0000-0002-6709-2531
De Matteis, Giuseppe
Franceschi, Francesco
Letter
Japan
Geriatr Gerontol Int. 2020 Oct 4. doi: 10.1111/ggi.14020.
PY  - 2020
SN  - 1447-0594
ST  - Authors' reply to: Comment to better understanding of the study "Clinical characteristics and prognostic factors in COVID-19 patients aged �?0 years"
T2  - Geriatrics & gerontology international
TI  - Authors' reply to: Comment to better understanding of the study "Clinical characteristics and prognostic factors in COVID-19 patients aged �?0 years"
ID  - 7785620
ER  - 

TY  - JOUR
AB  - OBJECTIVE: Mindfulness disposition is associated with various psychological factors and prevents emotional distress in chronic diseases. In the present study, we analyzed the key role of mindfulness dispositions in protecting the individual against psychological distress consequent to COVID-19 social distancing and quarantining. METHODS: An online survey was launched on March 13, 2020, with 6,412 responses by April 6, 2020. Socio-demographic information, exposure to the pandemic, and quarantining were assessed together with psychological distress and mindfulness disposition. Multivariate linear regression analysis was performed to study the influence of predictive factors on psychological distress and quality of life in Italian responders during the early days of lockdown. Pearson correlations were calculated to study the relationship between mindfulness and psychiatric symptoms. RESULTS: Multivariate linear regression run on socio-demographics, COVID-19-related variables, and mindfulness disposition as moderators of overall psychological distress showed that mindfulness was the best predictor of psychological distress (β = -0.504; p  0.0001). High negative correlations were found between mindfulness disposition and the overall Global Severity Index (r = -0.637; p  0.0001), while moderate to high associations were found between mindfulness and all SCL-90 sub-scales. DISCUSSION: Findings showed that high dispositional mindfulness enhances well-being and helps in dealing with stressful situations such as the COVID-19 pandemic. Mindfulness-based mental training could represent an effective intervention to stem post-traumatic psychopathological beginnings and prevent the onset of chronic mental disorders.
AD  - Department of Surgical, Medical and Molecular Pathology, Critical and Care Medicine, University of Pisa, Pisa, Italy.
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
AN  - 33013503
AU  - Conversano, C.
AU  - Di Giuseppe, M.
AU  - Miccoli, M.
AU  - Ciacchini, R.
AU  - Gemignani, A.
AU  - Orrù, G.
C1  - 10/6/2020
C2  - PMC7516078
DB  - PubMed
DO  - 10.3389/fpsyg.2020.01900
DP  - NLM
ET  - 2020/10/06
J2  - Frontiers in psychology
KW  - Covid-19
Maas
Scl-90
adjustment
meditation
mindfulness
pandemic
psychological distress
LA  - eng
N1  - 1664-1078
Conversano, Ciro
Di Giuseppe, Mariagrazia
Miccoli, Mario
Ciacchini, Rebecca
Gemignani, Angelo
Orrù, Graziella
Journal Article
Front Psychol. 2020 Sep 11;11:1900. doi: 10.3389/fpsyg.2020.01900. eCollection 2020.
PY  - 2020
SN  - 1664-1078 (Print)
1664-1078
SP  - 1900
ST  - Mindfulness, Age and Gender as Protective Factors Against Psychological Distress During COVID-19 Pandemic
T2  - Frontiers in psychology
TI  - Mindfulness, Age and Gender as Protective Factors Against Psychological Distress During COVID-19 Pandemic
VL  - 11
ID  - 7785455
ER  - 

TY  - JOUR
AD  - S.J. Quinney College of Law and Department of Human Genetics, University of Utah, Salt Lake City, UT, USA. jorge.contreras@law.utah.edu.
Howard Hughes Medical Institute and University of California Berkeley, Berkeley, CA, USA.
Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Stanford Law School, Stanford, CA, USA.
University of Cambridge, Cambridge, UK.
Creative Commons, Mountain View, CA, USA.
Department of Engineering, Innovation and IP Management Laboratory, University of Cambridge, Cambridge, UK.
AN  - 33020626
AU  - Contreras, J. L.
AU  - Eisen, M.
AU  - Ganz, A.
AU  - Lemley, M.
AU  - Molloy, J.
AU  - Peters, D. M.
AU  - Tietze, F.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1038/s41587-020-0682-1
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Nature biotechnology
LA  - eng
N1  - 1546-1696
Contreras, Jorge L
Orcid: 0000-0002-7899-3060
Eisen, Michael
Ganz, Ariel
Lemley, Mark
Molloy, Jenny
Peters, Diane M
Tietze, Frank
Orcid: 0000-0002-2899-6415
Journal Article
United States
Nat Biotechnol. 2020 Oct;38(10):1146-1149. doi: 10.1038/s41587-020-0682-1.
PY  - 2020
SN  - 1087-0156
SP  - 1146-1149
ST  - Pledging intellectual property for COVID-19
T2  - Nature biotechnology
TI  - Pledging intellectual property for COVID-19
VL  - 38
ID  - 7785020
ER  - 

TY  - JOUR
AB  - BACKGROUND: The real impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on overall mortality remains uncertain as surveillance reports have attributed a limited number of deaths to novel coronavirus disease 2019 (COVID-19) during the outbreak. The aim of this study was to assess the excess mortality during the COVID-19 outbreak in highly impacted areas of northern Italy. METHODS: We analysed data on deaths that occurred in the first 4 months of 2020 provided by the health protection agencies (HPAs) of Bergamo and Brescia (Lombardy), building a time-series of daily number of deaths and predicting the daily standardised mortality ratio (SMR) and cumulative number of excess deaths through a Poisson generalised additive model of the observed counts in 2020, using 2019 data as a reference. RESULTS: We estimated that there were 5740 (95% credible set (CS) 5552-5936) excess deaths in the HPA of Bergamo and 3703 (95% CS 3535-3877) in Brescia, corresponding to a 2.55-fold (95% CS 2.50-2.61) and 1.93 (95% CS 1.89-1.98) increase in the number of deaths. The excess death wave started a few days later in Brescia, but the daily estimated SMR peaked at the end of March in both HPAs, roughly 2 weeks after the introduction of lockdown measures, with significantly higher estimates in Bergamo (9.4, 95% CI 9.1-9.7). CONCLUSION: Excess mortality was significantly higher than that officially attributed to COVID-19, disclosing its hidden burden likely due to indirect effects on the health system. Time-series analyses highlighted the impact of lockdown restrictions, with a lower excess mortality in the HPA where there was a smaller delay between the epidemic outbreak and their enforcement.
AD  - Center for Public Health Research, University of Milano - Bicocca, Monza, Italy.
Health Protection Agency of Bergamo (ATS Bergamo), Bergamo, Italy.
Value-based Healthcare Unit, IRCCS Multimedica, Sesto San Giovanni, Italy.
Health Protection Agency of Brescia (ATS Brescia), Brescia, Italy.
Center for Leadership in Medicine Research and Studies, Università Cattolica del Sacro Cuore, Rome, Italy.
Dept of Medical Sciences, University of Ferrara, Ferrara, Italy.
AN  - 33015145
AU  - Conti, S.
AU  - Ferrara, P.
AU  - Mazzaglia, G.
AU  - D'Orso, M. I.
AU  - Ciampichini, R.
AU  - Fornari, C.
AU  - Madotto, F.
AU  - Magoni, M.
AU  - Sampietro, G.
AU  - Silenzi, A.
AU  - Sileo, C. V.
AU  - Zucchi, A.
AU  - Cesana, G.
AU  - Manzoli, L.
AU  - Mantovani, L. G.
C1  - 10/6/2020
C2  - PMC7520169 Ferrara has nothing to disclose. Conflict of interest: G. Mazzaglia has nothing to disclose. Conflict of interest: M.I. D'Orso has nothing to disclose. Conflict of interest: R. Ciampichini has nothing to disclose. Conflict of interest: C. Fornari has nothing to disclose. Conflict of interest: F. Madotto has nothing to disclose. Conflict of interest: M. Magoni has nothing to disclose. Conflict of interest: G. Sampietro has nothing to disclose. Conflict of interest: A. Silenzi has nothing to disclose. Conflict of interest: C.V. Sileo has nothing to disclose. Conflict of interest: A. Zucchi has nothing to disclose. Conflict of interest: G. Cesana has nothing to disclose. Conflict of interest: L. Manzoli has nothing to disclose. Conflict of interest: L.G. Mantovani has nothing to disclose.
DA  - Jul
DB  - PubMed
DO  - 10.1183/23120541.00458-2020
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - ERJ open research
LA  - eng
N1  - 2312-0541
Conti, Sara
Orcid: 0000-0002-5774-3740
Ferrara, Pietro
Orcid: 0000-0002-0349-3221
Mazzaglia, Giampiero
D'Orso, Marco I
Ciampichini, Roberta
Fornari, Carla
Madotto, Fabiana
Magoni, Michele
Sampietro, Giuseppe
Silenzi, Andrea
Sileo, Claudio V
Zucchi, Alberto
Cesana, Giancarlo
Manzoli, Lamberto
Mantovani, Lorenzo G
Journal Article
ERJ Open Res. 2020 Sep 28;6(3):00458-2020. doi: 10.1183/23120541.00458-2020. eCollection 2020 Jul.
PY  - 2020
SN  - 2312-0541 (Print)
2312-0541
ST  - Magnitude and time-course of excess mortality during COVID-19 outbreak: population-based empirical evidence from highly impacted provinces in northern Italy
T2  - ERJ open research
TI  - Magnitude and time-course of excess mortality during COVID-19 outbreak: population-based empirical evidence from highly impacted provinces in northern Italy
VL  - 6
ID  - 7785329
ER  - 

TY  - JOUR
AB  - SARS-Cov-2 infection causes local and systemic inflammation mediated by pro-inflammatory cytokines and COX-2 eicosanoid products with metabolic dysfunction and tissue damage that can lead to patient death. These effects are primarily induced by IL-1 cytokines, which are involved in the elevation of hepatic acute phase proteins and fever. IL-1 has a broad spectrum of biological activities and participates in both innate and acquired immunity. In infections, IL-1 induces gene expression and synthesis of several cytokines/chemokines in both macrophages and mast cells (MCs). The activation of MCs triggers the secretion of mediators stored in the granules, and the de novo synthesis of pro-inflammatory cytokines. In microorganism infections, the release of IL-1 macrophage acts on adhesion molecules and endothelial cells leading to hypotension and septic shock syndrome. IL-1 activated by SARS-CoV-2 stimulates the secretion of TNF, IL-6 and other cytokines, a pro-inflammatory complex that can lead to cytokine storm and be deleterious in both lung and systemically. In SARS-CoV-2 septic shock, severe metabolic cellular abnormalities occur which can lead to death. Here, we report that SARS-CoV-2 induces IL-1 in macrophages and MCs causing the induction of gene expression and activation of other pro-inflammatory cytokines. Since IL-1 is toxic, its production from ubiquitous MCs and macrophages activated by SARS-CoV-2 can also provokes both gastrointestinal and brain disorders. Furthermore, in these immune cells, IL-1 also elevates nitric oxide, and the release of inflammatory arachidonic acid products such as prostaglndins and thromboxane A2. All together these effects can generate cytokine storm and be the primary cause of severe inflammation with respiratory distress and death. Although, IL-1 administered in low doses may be protective; when it is produced in high doses in infectious diseases can be detrimental, Therefore, IL-1 blockade has been studied in many human diseases including sepsis, resulting that blocking it is absolutely necessary. This definitely nurtures hope for a new effective therapeutic treatment. Recently, two interesting anti-IL-1 cytokines have been widely described: IL-37 and IL-1Ra. IL-37, by blocking IL-1, has been observed to have anti-inflammatory action in rodents, in vivo and in transfected cells. It has been reported that IL-37 is a very powerful protein which inhibits inflammation and its inhibition can be a valid therapeutic strategy. IL-37 is a natural suppressor of inflammation that is generated through a caspase-1 that cleaves pro-IL-37 into mature IL-37 which translocates to the nucleus and inhibits the transcription of pro-inflammatory genes; while IL-1Ra inhibits inflammation by binding IL-1 to its IL-1R (receptor). We firmly believe that blocking IL-1 with an anti-inflammatory cytokine such as IL-37 and/or IL-1Ra is an effective valid therapy in a wide spectrum of inflammatory disorders including SARS-CoV-2-induced COVID-19. Here, we propose for the first time that IL-37, by blocking IL-1, may have an important role in the therapy of COVID-19.
AD  - Postgraduate Medical School, University of Chieti, 66013 Chieti, Italy.
School of Pharmacy, University of Camerino, Camerino, Italy.
Molecular Medicine, Department of Morphology, Surgery, Experimental Medicine, University of Ferrara, Ferrara, Italy.
University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Department of Microbiology, University of Thessaloniki, 54124 Thessaloniki, Greece.
School of Veterinary Medicine, University of Thessaloniki, 54124 Thessaloniki, Greece.
Centro Medico "Mai più Dolore", Pescara, Italy.
Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, 00100 Roma, Italy.
AN  - 33016027
AU  - Conti, P.
AU  - Caraffa, A.
AU  - Gallenga, C. E.
AU  - Ross, R.
AU  - Kritas, S. K.
AU  - Frydas, I.
AU  - Younes, A.
AU  - Ronconi, G.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.23812/20-1-e
DP  - NLM
ET  - 2020/10/06
IS  - 6
J2  - Journal of biological regulators and homeostatic agents
KW  - Covid-19
Il-1
Il-6
SARS-CoV-2
immunity
lung inflammation
macrophages and mast cells
LA  - eng
N1  - Conti, P
Caraffa, Al
Gallenga, C E
Ross, R
Kritas, S K
Frydas, I
Younes, A
Ronconi, G
Editorial
Italy
J Biol Regul Homeost Agents. 2020 Oct 5;34(6). doi: 10.23812/20-1-E.
PY  - 2020
SN  - 0393-974X (Print)
0393-974x
ST  - Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy
T2  - Journal of biological regulators and homeostatic agents
TI  - Coronavirus-19 (SARS-CoV-2) induces acute severe lung inflammation via IL-1 causing cytokine storm in COVID-19: a promising inhibitory strategy
VL  - 34
ID  - 7785230
ER  - 

TY  - JOUR
AB  - IMPACT This paper examines an under-researched aspect of crisis management operations in the British civil service-the work of the Stabilisation Unit This unit offers important lessons in the delivery of joined-up government and application of civil service training functions as a crucial element in building capacity within the machinery of government The Stabilisation Unit, although not without its challenges, has the potential to provide a blueprint for organizing external crisis management operations as part of the work of a modern bureaucracy, across other parts of the UK system of government, and also within other states This paper was researched and written before the outbreak of the Covid-19 pandemic, but the findings here regarding the enhancement of crisis management capacities within government have a clear relevance in that context This paper examines the training and development dimensions of a relatively recent entity within the British civil service-the Stabilisation Unit (SU) Now accountable to UK National Security Council, the unit came into being in 2007 in order to co-ordinate work between the Foreign &amp; Commonwealth Office, the Department for International Development, and the Ministry of Defence in the wake of military interventions in Iraq and Afghanistan The unit now has a broad crisis prevention and response function This paper shows how the unit has become an important training and capacity building feature of the modern British civil service The concluding argument is that there is considerable potential for the unit to be an organizational agent for joining-up government as part of a renewed modernization agenda for civil service learning, training and development
AU  - Connolly, John
AU  - Pyper, Robert
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Developing capacity within the British civil service: the case of the Stabilisation Unit
T2  - Public Money & Management
TI  - Developing capacity within the British civil service: the case of the Stabilisation Unit
UR  - https://doi.org/10.1080/09540962.2020.1750797
ID  - 7788222
ER  - 

TY  - JOUR
AB  - This retrospective, cross-sectional study was conducted in four community hospitals in Los Angeles County, California. The assumption of this study was, coronavirus disease-19 (COVID-19) contributed to the increase in healthcare workers (HCW) compliance with infection prevention measures. IP initiatives fostered among HCWs have increased awareness of effective hand washing, cleaning equipment after use and appropriate personal protective equipment (PPE) use which has subsequently decreased healthcare acquired infections (HAI) with multidrug-resistant organisms (MDRO).
AN  - 33011335
AU  - Cole, J.
AU  - Barnard, E.
C1  - 10/6/2020
C2  - PMC7529600
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.ajic.2020.09.013
DP  - NLM
ET  - 2020/10/05
J2  - American journal of infection control
KW  - Covid-19
Multidrug resistant organisms
hand washing
healthcare acquired infection
personal protective equipment
LA  - eng
N1  - 1527-3296
Cole, Jennifer
Barnard, Emily
Journal Article
Am J Infect Control. 2020 Oct 1:5726. doi: 10.1016/j.ajic.2020.09.013.
PY  - 2020
SN  - 0196-6553 (Print)
0196-6553
SP  - 5726
ST  - The Impact of the COVID-19 Pandemic on Healthcare Acquired Infections with Multidrug Resistant Organisms
T2  - American journal of infection control
TI  - The Impact of the COVID-19 Pandemic on Healthcare Acquired Infections with Multidrug Resistant Organisms
ID  - 7785677
ER  - 

TY  - JOUR
AB  - This study investigates the forces that contributed to severe shortages in personal protective equipment in the US during the COVID-19 crisis. Problems from a dysfunctional costing model in hospital operating systems were magnified by a very large demand shock triggered by acute need in healthcare and panicked marketplace behavior that depleted domestic PPE inventories. The lack of appropriate action on the part of the federal government to maintain and distribute domestic inventories, as well as severe disruptions to the PPE global supply chain, amplified the problem. Analysis of trade data shows that the US is the world's largest importer of face masks, eye protection, and medical gloves, making it highly vulnerable to disruptions in exports of medical supplies. We conclude that market prices are not appropriate mechanisms for rationing inputs to health because health is a public good. Removing the profit motive for purchasing PPE in hospital costing models and pursuing strategic industrial policy to reduce the US dependence on imported PPE will both help to better protect healthcare workers with adequate supplies of PPE.
AD  - Department of Global and Intercultural Studies, Miami University, 501 E. High St. Oxford, OH 45056, USA; Ezintsha, Wits Reproductive Health and HIV Institute, Department of Medicine, Faculty of Health Sciences, 32 Princess of Wales Terr., Sunnyside Office Park, Block D, Floor 5, University of the Witwatersrand, Johannesburg 2193, South Africa. Electronic address: cohenje@miamioh.edu.
Department of Women's and Gender Studies, Department of Labor Studies and Employment Relations, Rutgers University, 94 Rockafeller Road, Piscataway, NJ 08854, USA.
AN  - 33017601
AU  - Cohen, J.
AU  - van der Meulen Rodgers, Y.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.ypmed.2020.106263
DP  - NLM
ET  - 2020/10/06
J2  - Preventive medicine
KW  - Covid-19
Coronavirus
Gloves
N95
Nurses
Ppe
Personal protective equipment
Public good
Shortage
Supply chain
LA  - eng
N1  - 1096-0260
Cohen, Jennifer
van der Meulen Rodgers, Yana
Journal Article
Review
United States
Prev Med. 2020 Oct 2:106263. doi: 10.1016/j.ypmed.2020.106263.
PY  - 2020
SN  - 0091-7435
SP  - 106263
ST  - Contributing factors to personal protective equipment shortages during the COVID-19 pandemic
T2  - Preventive medicine
TI  - Contributing factors to personal protective equipment shortages during the COVID-19 pandemic
ID  - 7785127
ER  - 

TY  - JOUR
AB  - A disposable enzyme-linked immunosorbent assay (dELISA) device for ate-home or doctor’s office use was developed to detect SARS-CoV-2 antibodies. Serology testing for SARS-CoV-2 antibodies is currently run using well-plate ELISAs in centralized laboratories. However, the scale of serology testing needed for epidemiological and clinical screening studies will overwhelm existing clinical laboratory resources. Instead, a point-of-need device that can be used at home or in doctor’s offices for COVID-19 serology testing must be developed and is one of four target products prioritized by the World Health Organization. Lateral flow assays are common and easy to use, but lack the sensitivity needed to reliably detect SARS-CoV-2 antibodies in clinical samples. This work describes a disposable ELISA device that is as simple to use as a lateral flow assay, but as sensitive as a well-plate ELISA. The device utilizes capillary-driven flow channels made of transparency films and double-sided adhesive combined with paper pumps to drive flow. The geometry of the channels and storage pads enables automated sequential washing and reagent addition steps with two simple end-user steps. An enzyme label is used to produce a colorimetric signal instead of a nanoparticle label in order to amplify signal and increase sensitivity, while the integrated washing steps decrease false positives and increase reproducibility. Naked-eye detection can be used for qualitative results or a smartphone camera for quantitative analysis. The device can detect antibodies at 2.8 ng/mL from whole blood, which was very close the concentration of detectable target in a well-plate ELISA (1.2 ng/mL). In this study the dELISA system was used to detect SARS-CoV-2 antibodies, but we believe that the device represents a fundamental step forward in point-of-care technology that will enable sensitive detection of many other analytes outside of a centralized laboratory.
AU  - Cody, Carrell
AU  - Jeremy, Link
AU  - Ilhoon, Jang
AU  - James, Terry
AU  - Michael, Scherman
AU  - Zachary, Call
AU  - Yosita, Panraksa
AU  - David S., Dandy
AU  - Brian J., Geiss
AU  - Charles, Henry
C1  - 10/6/2020
DB  - chemRxiv
DO  - 10.26434/chemrxiv.13050539.v1
DP  - chemRxiv
KW  - immunoassay
capillary-driven flow
serology
microfluidics
COVID-19
PY  - 2020
ST  - Point-of-Need Disposable ELISA System for COVID-19 Serology Testing (preprint)
T2  - chemRxiv
TI  - Point-of-Need Disposable ELISA System for COVID-19 Serology Testing (preprint)
UR  - https://chemrxiv.org/articles/preprint/Point-of-Need_Disposable_ELISA_System_for_COVID-19_Serology_Testing/13050539
ID  - 7788893
ER  - 

TY  - JOUR
AU  - Ciuriak, Dan
AU  - Malkin, Anton
AU  - Ireland, Derek
AU  - Stanley, Guy
AU  - Wilson, Craig
AU  - Wynne, David
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Supply Chains
Paperless Trade/Digitalization/E-commerce
Competition Policy
PY  - 2020
ST  - Resilience Under Crisis: Proposals and Considerations for Regional and Other Trade Agreements (preprint)
T2  - SSRN
TI  - Resilience Under Crisis: Proposals and Considerations for Regional and Other Trade Agreements (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693119
ID  - 7788909
ER  - 

TY  - JOUR
AD  - (Ciotti) Washington University School of Medicine, St. Louis, MO, United States (Grebenciucova) Northwestern University Feinberg School of Medicine, Chicago, IL, United States (Moss) Cleveland Clinic Mellen Center for MS, Cleveland, OH, United States (Newsome) Johns Hopkins University School of Medicine, Baltimore, MD, United States
J.R. Ciotti, Washington University School of Medicine, St. Louis, MO, United States. E-mail: ciottij@wustl.edu
AN  - 2006834619
AU  - Ciotti, J. R.
AU  - Grebenciucova, E.
AU  - Moss, B. P.
AU  - Newsome, S. D.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1002/ana.25907
DP  - Ovid Technologies
KW  - article
coronavirus disease 2019
human
multiple sclerosis
LA  - English
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 0364-5134
1531-8249
ST  - Multiple Sclerosis Disease-Modifying Therapies in the COVID-19 Era
T2  - Annals of Neurology
TI  - Multiple Sclerosis Disease-Modifying Therapies in the COVID-19 Era
UR  - http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1531-8249
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006834619
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:32951235&id=10.1002%2Fana.25907&issn=0364-5134&isbn=&volume=&issue=&spage=&pages=&date=2020&title=Annals+of+Neurology&atitle=Multiple+Sclerosis+Disease-Modifying+Therapies+in+the+COVID-19+Era&aulast=Ciotti&pid=%3Cauthor%3ECiotti+J.R.%2CGrebenciucova+E.%2CMoss+B.P.%2CNewsome+S.D.%3C%2Fauthor%3E&%3CAN%3E2006834619%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
ID  - 7783120
ER  - 

TY  - JOUR
AB  - Here we report a single-center cohort of 6 patients (4 kidney only, and 2 simultaneous liver/kidney transplants) diagnosed with COVID-19 at a median of 1.9 years (range = 0.2-9.3 years) post transplant. Five (of 6) patients required inpatient admission, 2 patients (mortality = 33%) died. Among those with mortality, an increased concentration of inflammatory biomarkers (interleukin-6 and C-reactive protein) was noted with a lack of response to interleukin-6 blockade, remdesivir, and/or convalescent plasma. None of the kidney-only transplants (4/6; 67%) had elevation in plasma donor-derived cell-free DNA above the previously published cut-off of 1%, suggesting absence of significant allo-immune injury. Four (of 5) admitted patients had detectable SARS-CoV-2 (severe acute respiratory syndrome-coronavirus 2) in blood on samples obtained at/during hospitalization. Of the 4 discharged patients, 2 patients with undetectable virus on repeat nasopharyngeal swabs had seroconversion with positive SARS-CoV-2 IgG formation at 30 to 48 days post infection. One patient had prolonged shedding of virus on nasopharyngeal swab at 28 days post discharge despite lack of symptoms. In this preliminary report, we find that immunocompromised transplant patients had higher rates of RNAemia (67%) than reported in the general population (15%), seeming absence of allo-immune injury despite systemic inflammation, and formation of IgG overtime after recovery from infection.
AD  - Division of Nephrology, Virginia Commonwealth University, Richmond, Virginia.
Department of Pathology, Virginia Commonwealth University, Richmond, Virginia.
Kashi Clinical Laboratories Inc, Portland, Oregon.
Hume-Lee Transplant Center, Virginia Commonwealth University, Richmond, Virginia.
Division of Nephrology, Virginia Commonwealth University, Richmond, Virginia. Electronic address: gaurav.gupta@vcuhealth.org.
AN  - 33012543
AU  - Christensen, J.
AU  - Kumar, D.
AU  - Moinuddin, I.
AU  - Bryson, A.
AU  - Kashi, Z.
AU  - Kimball, P.
AU  - Levy, M.
AU  - Kamal, L.
AU  - King, A.
AU  - Gupta, G.
C1  - 10/6/2020
DA  - Sep 3
DB  - PubMed
DO  - 10.1016/j.transproceed.2020.08.042
DP  - NLM
ET  - 2020/10/06
J2  - Transplantation proceedings
LA  - eng
N1  - 1873-2623
Christensen, Johanna
Kumar, Dhiren
Moinuddin, Irfan
Bryson, Alexandra
Kashi, Zahra
Kimball, Pamela
Levy, Marlon
Kamal, Layla
King, Anne
Gupta, Gaurav
Journal Article
United States
Transplant Proc. 2020 Sep 3:S0041-1345(20)32709-3. doi: 10.1016/j.transproceed.2020.08.042.
PY  - 2020
SN  - 0041-1345
ST  - Coronavirus Disease 2019 Viremia, Serologies, and Clinical Course in a Case Series of Transplant Recipients
T2  - Transplantation proceedings
TI  - Coronavirus Disease 2019 Viremia, Serologies, and Clinical Course in a Case Series of Transplant Recipients
ID  - 7785571
ER  - 

TY  - JOUR
AB  - This research investigates the impacts of the novel coronavirus disease, also referred to as COVID-19 pandemic, on the food and beverage industry. It examines both short-term and medium-to-long-term impacts of the pandemic and outlines strategies to reduce the potential consequences of those impacts. To this end, we use a qualitative, multiple-case-study methodology, collecting data from eight sample companies with fourteen respondents in the food and beverage industry in Bangladesh. The findings show that the short-term impacts of this pandemic, such as product expiry, shortage of working capital, and limited operations of distributors, are severe, while the medium-to-long-term impacts promise to be complex and uncertain. In the longer term, various performance metrics, such as return on investment by the firms, the contribution of the firms to the gross domestic product (GDP), and employee size, are all expected to decrease. Moreover, firms may need to restructure their supply chain and build relationships with new distributors and trade partners. The study proposes several strategies that managers in this sector can adopt to improve resiliency in the changing environment during and after the COVID-19 era. While this research is novel and contributes to both theory and practice, it does not consider small and medium-sized companies in the food and beverage industry. Therefore, the impacts and strategies we identify may not apply to smaller companies. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
AD  - Abdul Monem Ltd., Barishal, Bangladesh
Melbourne, Australia
UTS Business School, University of Technology Sydney, Sydney, Australia
Institute of Leather Engineering and Technology, University of Dhaka, Dhaka, Bangladesh
AU  - Chowdhury, M. T.
AU  - Sarkar, A.
AU  - Paul, S. K.
AU  - Moktadir, M. A.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s12063-020-00166-9
J2  - Oper. Manage. Res.
KW  - COVID-19 pandemic
Food and beverage industry
Impacts
Resiliency
Strategies
Sustainability
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Paul, S.K.; UTS Business School, University of Technology SydneyAustralia; email: sanjoy.paul@uts.edu.au
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PY  - 2020
SN  - 19369735 (ISSN)
ST  - A case study on strategies to deal with the impacts of COVID-19 pandemic in the food and beverage industry
T2  - Operations Management Research
TI  - A case study on strategies to deal with the impacts of COVID-19 pandemic in the food and beverage industry
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091725668&doi=10.1007%2fs12063-020-00166-9&partnerID=40&md5=313413768eb4ea18b61839fb5e97ceb9
ID  - 7783302
ER  - 

TY  - JOUR
AB  - Background: Recent literature regarding the outcome of cancer patients infected with COVID-19 are not encouraging. Nevertheless, current evidence on the risk and benefits of continuing oncological treatment of cancer patients during the pandemic remains insufficient. We provide our experience in a center with high access for patients with COVID-19-associated pneumonia in Lombardy, Italy. We conducted a retrospective study using a prospectively maintained database of patients admitted to our hospital between 25 February 2020 and 9 April 2020 with a confirmed diagnosis of COVID-19 pneumonia. Results: A total of 53 patients with a history or current oncological disease were included in this study. Sixteen oncological patients (30.2%) died during hospitalization. Multivariable logistic regression analysis found that age (Odds ratio [OR]: 1.17, p�?�?.009), diabetes (OR: 15.05, p�?�?.028) and active oncological disease (OR 13.60, p�?�?.015) were independently associated with in-hospital mortality. The mortality rate of the total number of cancer patients is about twice as high as that of non-oncological patients admitted to our hospital with a diagnosis of COVID-19. Conclusion: The presence of active oncological disease is independently related to mortality as well as age and diabetes. The majority of patients who died were frail. Careful evaluation of the risks and benefits of treatment in frail patients is needed, considering that difficult access to intensive care may have affected the mortality rate.
AD  - Department of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy ; Department of Surgery, Fondazione Poliambulanza, Brescia, Italy ; Department of Oncology, Fondazione Poliambulanza, Brescia, Italy ; Department of Clinical Oncology, Fondazione Poliambulanza, Brescia, Italy
AN  - 2448299649
AU  - Cherri, Sara
AU  - Lemmers Daniel, H. L.
AU  - Noventa, Silvia
AU  - Abu Hilal, Mohammed
AU  - Zaniboni, Alberto
C1  - 10/6/2020
DA  - Jan 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1177/1758835920962370
DP  - ProQuest Central
KW  - Medical Sciences--Oncology
cancer
chemotherapy
COVID-19
immunodeficiency
SARS-CoV-2
Diabetes
Pneumonia
Mortality
Cost-benefit analysis
Diabetes mellitus
Patients
Coronaviruses
Diagnosis
Pandemics
Italy
LA  - English
N1  - Copyright - © The Author(s), 2020. This work is licensed under the Creative Commons  Attribution �?Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
SubjectsTermNotLitGenreText - Italy
PY  - 2020
SN  - 17588340
ST  - Outcome of oncological patients admitted with COVID-19: experience of a hospital center in northern Italy
T2  - Therapeutic Advances in Medical Oncology
TI  - Outcome of oncological patients admitted with COVID-19: experience of a hospital center in northern Italy
UR  - https://www.proquest.com/docview/2448299649?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=Outcome+of+oncological+patients+admitted+with+COVID-19%3A+experience+of+a+hospital+center+in+northern+Italy&title=Therapeutic+Advances+in+Medical+Oncology&issn=17588340&date=2020-01-01&volume=12&issue=&spage=&au=Cherri+Sara%3BLemmers+Daniel+H+L%3BNoventa+Silvia%3BAbu+Hilal+Mohammed%3BZaniboni+Alberto&isbn=&jtitle=Therapeutic+Advances+in+Medical+Oncology&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1177%2F1758835920962370
https://journals.sagepub.com/doi/10.1177/1758835920962370
VL  - 12
ID  - 7784931
ER  - 

TY  - JOUR
AD  - Henry Bronson Professor of Pharmacology, Yale University, New Haven, USA. yccheng@yale.edu.
AN  - 33017034
AU  - Cheng, Y. C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1007/s11655-020-3432-9
DP  - NLM
ET  - 2020/10/06
J2  - Chinese journal of integrative medicine
LA  - eng
N1  - Cheng, Yung-Chi
Journal Article
China
Chin J Integr Med. 2020 Oct 5. doi: 10.1007/s11655-020-3432-9.
PY  - 2020
SN  - 1672-0415 (Print)
1672-0415
ST  - Integrative Medicine Demonstrates Advantage in COVID-19 Treatment
T2  - Chinese journal of integrative medicine
TI  - Integrative Medicine Demonstrates Advantage in COVID-19 Treatment
ID  - 7785167
ER  - 

TY  - JOUR
AD  - SingHealth Emergency Medicine Residency Programme, Singapore Health Services, Singapore.
Department of Emergency Medicine, Singapore General Hospital, Singapore.
AN  - 33014222
AU  - Cheng, J.
AU  - Chowdhury, S. R.
AU  - Dutta, A.
AU  - Ponampalam, R.
C1  - 10/6/2020
C2  - PMC7517402
DB  - PubMed
DO  - 10.5847/wjem.j.1920-8642.2020.04.008
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - World journal of emergency medicine
LA  - eng
N1  - Cheng, Jenshen
Chowdhury, Susmita Roy
Dutta, Aliviya
Ponampalam, R
Case Reports
World J Emerg Med. 2020;11(4):255-257. doi: 10.5847/wjem.j.1920-8642.2020.04.008.
PY  - 2020
SN  - 1920-8642 (Print)
1920-8642
SP  - 255-257
ST  - Venous thromboembolism in a healthy young man: An unintended consequence of coronavirus disease 2019 pandemic lockdown
T2  - World journal of emergency medicine
TI  - Venous thromboembolism in a healthy young man: An unintended consequence of coronavirus disease 2019 pandemic lockdown
VL  - 11
ID  - 7785414
ER  - 

TY  - GEN
AN  - NCT04577105
AU  - Chavez, Instituto Nacional de Cardiologia Ignacio
C1  - 10/6/2020
DA  - April 1
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19|ARDS|Pneumonia, Viral|Computed Tomography
N1  - No Results Available
Diagnostic Test: Simple chest tomography
Assessment of the level of suspicion of SARS-CoV2 infection|Evaluate the severity degree of pulmonary affection by chest computed tomography|Percentage of patients requiring endotracheal intubation|Death from any cause|Modified Sequential Organ Failure Assessment (mSOFA)|Sepsis-induced coagulopathy (SIC)|National Early Warning Scale (NEWS 2)|COVID-GRAM severe illness risk score|Rapid Severity Index for COVID-19 (qCSI)|Neutrophil-Lymphocyte Ratio (NLR)|Alveolar-arterial gradient of oxygen|Berlin Criteria for Acute Respiratory Distress Syndrome
All
233
Other
Observational Model: Cohort|Time Perspective: Retrospective
20-1177
October 1, 2020
PB  - https://ClinicalTrials.gov/show/NCT04577105
PY  - 2020
ST  - Risk Factors and Computed Tomography Findings in SARS-COV2 Infected Patients
T2  - ClinicalTrials
TI  - Risk Factors and Computed Tomography Findings in SARS-COV2 Infected Patients
UR  - https://ClinicalTrials.gov/show/NCT04577105
ID  - 7788862
ER  - 

TY  - JOUR
AB  - An outbreak of COVID-19 among farmworkers could have significant impacts on the workers, agricultural producers, and the consumers Farmers are implementing new labor management practices to slow the spread of the virus among workers Since immigration is temporarily restricted, farmers may have difficulty securing a sufficient workforce We test whether changes in the unemployment rate affected H-2A guest worker demand before the pandemic and find a statistically significant negative impact Nevertheless, we expect that H-2A recruitment will be vital to sustaining agricultural production We conclude by discussing potential long-term impacts of the pandemic on farm labor supply and demand This article is protected by copyright All rights reserved
AU  - Charlton, Diane
AU  - Castillo, Marcelo
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Potential Impacts of a Pandemic on the U.S. Farm Labor Market
T2  - Applied Economic Perspectives and Policy
TI  - Potential Impacts of a Pandemic on the U.S. Farm Labor Market
UR  - https://doi.org/10.1002/aepp.13105
ID  - 7788131
ER  - 

TY  - JOUR
AB  - The SARS-Cov-2 (COVID-19) virus, first diagnosed in China in December 2019, causes an infectious and multisystem disease. Having evolved rapidly, with an exponential increase in the number of cases and deaths worldwide, COVID-19 was declared a pandemic by the WHO in mid-March 2020. Although in most Sub-Saharan African countries the pandemic is in its initial phase, as of September 8, 2020, the cumulative total cases of COVID-19 in Africa stands at 1 315 073 confirmed cases and 31 725 deaths.
AD  - Provincial Health Administration, DPS Manica, Manica Province, Mozambique.
Department of Obstetrics and Gynecology, University of Campinas, School of Medicine, Campinas, São Paulo, Brazil.
Department of Population Family and Reproductive Health, University of Ghana, Accra, Ghana.
National Institute of Public Health of Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Department of Obstetrics and Gynecology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
Department of Obstetrics and Gynecology, Maputo Central Hospital, Maputo, Mozambique.
Department of Epidemiology and Disease control, School of Public Health, University of Ghana, Accra, Ghana.
Clinique Gynécologique et Obstétricale de l'Hôpital Aristide Le Dantec, Dakar, Senegal.
Department of Microbiology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique.
AN  - 33020902
AU  - Charles, C. M.
AU  - Modey Amoah, E.
AU  - Kourouma, K. R.
AU  - Bahamondes, L. G.
AU  - Cecatti, J. G.
AU  - Osman, N. B.
AU  - Govule, P.
AU  - Diallo, A. K.
AU  - Sacarlal, J.
AU  - de Carvalho Pacagnella, R.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/ijgo.13403
DP  - NLM
ET  - 2020/10/07
J2  - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
KW  - Africa
Covid-19
Low- and middle-income countries
Network
SARS-CoV-2
Severe maternal morbidity
LA  - eng
N1  - 1879-3479
Charles, Charles M'poca
Modey Amoah, Emefa
Kourouma, Kadidiatou Raissa
Bahamondes, Luis Guilhermo
Cecatti, José Guilherme
Osman, Nafissa Bique
Govule, Philip
Diallo, Abdou Karim
Sacarlal, Jahit
de Carvalho Pacagnella, Rodolfo
Journal Article
United States
Int J Gynaecol Obstet. 2020 Oct 5. doi: 10.1002/ijgo.13403.
PY  - 2020
SN  - 0020-7292
ST  - The SARS-CoV-2 pandemic scenario in Africa: What should be done to address the needs of pregnant women?
T2  - International journal of gynaecology and obstetrics: official organ of International Federation of Gynaecology and Obstetrics
TI  - The SARS-CoV-2 pandemic scenario in Africa: What should be done to address the needs of pregnant women?
ID  - 7784968
ER  - 

TY  - JOUR
AB  - The severe acute respiratory syndrome-coronavirus-2 (commonly known as SARS-CoV-2) is a novel coronavirus (designated as 2019-nCoV), which was isolated for the first time after the Chinese health authorities reported a cluster of pneumonia cases in Wuhan, China in December 2019. Optimal management of the Coronavirus Disease-2019 disease is evolving quickly and treatment guidelines, based on scientific evidence and experts' opinions with clinical experience, are constantly being updated. On January 30, 2020, the World Health Organization declared the SARS-CoV-2 outbreak as a "Public Health Emergency of International Concern". The total lack of immune protection brought about a severe spread of the contagion all over the world. For this reason, diagnostic tools, patient management and therapeutic approaches have been tested along the way, in the desperate race to break free from the widespread infection and its fatal respiratory complications. Current medical knowledge and research on severe and critical patients' management and experimental treatments are still evolving, but several protocols on minimizing risk of infection among the general population, patients and healthcare workers have been approved and diffused by International Health Authorities. Copyright © The Author(s) 2020.
AD  - (Charitos) Department of Emergency and Urgency, National Poisoning Centre, Riuniti University Hospital of Foggia, Foggia 71122, Italy (Ballini) Department of Biosciences, Biotechnologies and Biopharmaceutics, University Campus E. Quagliariello, University of Bari Aldo Moro, Bari 70125, Italy (Ballini) Department of Precision Medicine, University of Campania Luigi Vanvitelli, Naples 80138, Italy (Bottalico, Santacroce) Interdepartmental Research Center for Pre-Latin, Latin and Oriental Rights and Culture Studies (CEDICLO), University of Bari, Bari 70121, Italy (Cantore) Department of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari 70124, Italy (Cantore) Sorriso and Benessere-Ricerca e Clinica S.R. L, Bari 70129, Italy (Passarelli) Department of Head, Neck and Sense Organs, Division of Oral Surgery and Implantology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Universita Cattolica del Sacro Cuore, Rome 00168, Italy (Inchingolo) Department of Interdisciplinary Medicine, Section of Dental Medicine, University of Bari Aldo Moro, Bari 70124, Italy (D'Addona) Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Fondazione Policlinico Universitario A. Gemelli IRCCS-Universita Cattolica del Sacro Cuore, Roma 00168, Italy (Santacroce) Ionian Department, Microbiology and Virology Laboratory, Policlinico University Hospital, University of Bari Aldo Moro, Bari 70124, Italy
A. Ballini, Department of Biosciences, Biotechnologies and Biopharmaceutics, University Campus E. Quagliariello, University of Bari Aldo Moro, via Orabona 4, Bari 70125, Italy. E-mail: andrea.ballini@uniba.it
AN  - 632998323
AU  - Charitos, I. A.
AU  - Ballini, A.
AU  - Bottalico, L.
AU  - Cantore, S.
AU  - Passarelli, P. C.
AU  - Inchingolo, F.
AU  - D'Addona, A.
AU  - Santacroce, L.
C1  - 10/6/2020
DA  - 26 Sep
DB  - Embase
DO  - http://dx.doi.org/10.12998/wjcc.v8.i18.3920
DP  - Ovid Technologies
IS  - 18
KW  - Acute respiratory distress syndrome
Antivirals
Clinical biochemistry
Clinical microbiology
Emergency and critical care medicine
Pandemics
SARS-CoV-2/COVID-19
Sepsis
Translational medicine
Viruses
adult
adult respiratory distress syndrome
China
clinical chemistry
complication
coronavirus disease 2019
experimental therapy
health care personnel
human
intensive care
microbiology
nonhuman
pandemic
patient care
practice guideline
race
review
Severe acute respiratory syndrome coronavirus 2
World Health Organization
antivirus agent
LA  - English
M3  - Review
PY  - 2020
SN  - 2307-8960 (electronic)
2307-8960
SP  - 3920-3933
ST  - Special features of SARS-CoV-2 in daily practice
T2  - World Journal of Clinical Cases
TI  - Special features of SARS-CoV-2 in daily practice
UR  - https://f6publishing.blob.core.windows.net/de4222b1-c9e1-47e2-8ad2-1d57cfb4483e/WJCC-8-3920.pdf
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=632998323
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.12998%2Fwjcc.v8.i18.3920&issn=2307-8960&isbn=&volume=8&issue=18&spage=3920&pages=3920-3933&date=2020&title=World+Journal+of+Clinical+Cases&atitle=Special+features+of+SARS-CoV-2+in+daily+practice&aulast=Charitos&pid=%3Cauthor%3ECharitos+I.A.%2CBallini+A.%2CBottalico+L.%2CCantore+S.%2CPassarelli+P.C.%2CInchingolo+F.%2CD%27Addona+A.%2CSantacroce+L.%3C%2Fauthor%3E&%3CAN%3E632998323%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 8
ID  - 7782819
ER  - 

TY  - JOUR
AB  - Coronavirus Disease 2019 (COVID-19) is an ongoing global pandemic affecting all levels of health systems. This includes the care of patients with noncommunicable diseases (NCDs) who bear a disproportionate burden of both COVID-19 itself and the public health measures enacted to combat it. In this review, we summarize major COVID-19 related considerations for NCD patients and their care providers, focusing on cardiovascular, pulmonary, renal, hematologic, oncologic, traumatic, obstetric/gynecologic, operative, psychiatric, rheumatologic/immunologic, neurologic, gastrointestinal, ophthalmologic, and endocrine disorders. Additionally, we offer a general framework for categorizing the pandemic's disruptions by disease-specific factors, direct health system factors, and indirect health system factors. We also provide references to major NCD medical specialty professional society statements and guidelines on COVID-19. COVID-19 and its control policies have already resulted in major disruptions to the screening, treatment, and surveillance of NCD patients. In addition, it differentially impacts those with pre-existing NCDs and may lead to de novo NCD sequelae. Likely, there will be long-term effects from this pandemic that will continue to affect practitioners and patients in this field for years to come.
AD  - Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA.
Department of Medicine, Stanford University, Stanford, CA, USA.
Center for Innovation in Global Health, Stanford University, Stanford, CA, USA.
Division of Primary Care and Population Health, Stanford University, Stanford, CA, USA.
AN  - 33020988
AU  - Chang, A. Y.
AU  - Cullen, M. R.
AU  - Harrington, R. A.
AU  - Barry, M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/joim.13184
DP  - NLM
ET  - 2020/10/07
J2  - Journal of internal medicine
KW  - Covid-19
Chronic Diseases
Noncommunicable Diseases
Public Health
LA  - eng
N1  - 1365-2796
Chang, Andrew Y
Orcid: 0000-0002-3009-6678
Cullen, Mark R
Harrington, Robert A
Barry, Michele
Journal Article
Review
England
J Intern Med. 2020 Oct 5. doi: 10.1111/joim.13184.
PY  - 2020
SN  - 0954-6820
ST  - The Impact of Novel Coronavirus COVID-19 on Non-Communicable Disease Patients and Health Systems: A Review
T2  - Journal of internal medicine
TI  - The Impact of Novel Coronavirus COVID-19 on Non-Communicable Disease Patients and Health Systems: A Review
ID  - 7784965
ER  - 

TY  - JOUR
AD  - IRCCS MultiMedica, Sesto San Giovanni, Milan, Italy. Electronic address: antonio.ceriello@hotmail.it.
AN  - 33011208
AU  - Ceriello, A.
C1  - 10/6/2020
C2  - PMC7529597
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.diabres.2020.108491
DP  - NLM
ET  - 2020/10/05
J2  - Diabetes research and clinical practice
KW  - Ace2
Covid-19
Sars-cov-2
cardiovascular disease
corticosteroids
diabetes
guidelines
hydroxychloroquine
hyperglycemia
thrombosis
LA  - eng
N1  - 1872-8227
Ceriello, Antonio
Editorial
Diabetes Res Clin Pract. 2020 Oct 1:108491. doi: 10.1016/j.diabres.2020.108491.
PY  - 2020
SN  - 0168-8227 (Print)
0168-8227
SP  - 108491
ST  - Lessons from COVID-19: how human behaviour may influence the science
T2  - Diabetes research and clinical practice
TI  - Lessons from COVID-19: how human behaviour may influence the science
ID  - 7785690
ER  - 

TY  - RPRT
A3  - Prevention, Centers for Disease Control and
AB  - Since 2015, the Centers for Disease Control and Prevention (CDC) and health departments across the United States have identified several HIV clusters and outbreaks occurring predominantly among people who inject drugs (PWID). Long-term declining trends in HIV incidence among people who inject drugs have stalled. The purpose of this Health Advisory is to alert public health departments and healthcare providers to the possibility of new injection-related HIV infections and outbreaks. This HAN provides guidance for preventing, identifying, and responding to HIV among people who inject drugs. It also provides considerations for delivering services in the context of the COVID-19 pandemic.

Background

HIV Outbreaks Among People Who Inject Drugs

Although HIV incidence among people who inject drugs declined substantially over many years, the ongoing misuse of opioids and other frequently injected substances are threatening this HIV prevention success. HIV diagnoses among people who inject drugs increased by 11% nationally from 2016 to 2018, with more pronounced increases among adults less than 40 years of age and non-Hispanic White adults.1 The COVID-19 pandemic complicates the delivery of essential services, including services for people who inject drugs, potentially hindering further efforts to address the increase in HIV transmission.

Multiple recent clusters and outbreaks have contributed to new HIV infections among people who inject drugs. Following a 2015 outbreak in Scott County, Indiana,2 increases in HIV among people who inject drugs, including several clusters and outbreaks of various sizes, have occurred across the United States in counties that span the rural-urban spectrum.3-14* People involved in such clusters and outbreaks frequently shared common characteristics: nonsterile injections multiple times per day; use of multiple substances (often opioids with methamphetamine or cocaine); marginalizing circumstances (homelessness or unstable housing, recent incarceration, exchange of sex for money or goods); and coinfection with hepatitis B virus (HBV), hepatitis C virus (HCV) and sexually transmitted infections (STIs).

CDC recently published a manuscriptexternal icon that synthesizes experiences and lessons learned from responses to six large HIV outbreaks among people who inject drugs.15 Although these outbreaks shared similarities, potential precipitating factors varied across outbreak settings. The outbreaks occurred in communities with varying levels of capacity to serve people who inject drugs; all offered some level of harm reduction services, including syringe services programs. Yet as part of outbreak response, health departments identified gaps in the delivery of harm reduction (e.g., limited access to syringe service programs and sterile injection equipment) and other services, highlighting the challenges of engaging a significantly marginalized population.

Syringe services programs are proven and effective community-based prevention programs that can provide a range of services, including access to sterile syringes and injection equipment, disposal of used syringes, vaccination, testing, naloxone, and linkage to medical care, including treatment for HIV and substance use disorder. Comprehensive syringe services programs and medication for opioid use disorder can independently reduce HIV and HCV transmission by half; when combined, these interventions can reduce transmission by more than two-thirds.16,17

Health departments can work with trusted community partners to effectively engage people who inject drugs with culturally competent practices. Prompt detection of and response to small numbers of HIV diagnoses may prevent larger outbreaks.

Clinical and Public Health Services to Address HIV Among People Who Inject Drugs in the Context of COVID-19

In the context of COVID-19, ongoing delivery of core clinical and public health services to address HIV and HCV among people who inject drugs is essential. Guidance for alternate means of service delivery when face-to-face services have been disrupted, and for minimizing the risk of SARS-CoV-2 transmission when services are provided in person, is provided in the recommendations. Also, service delivery models can be modified to reduce the number of face-to-face interactions. For example, syringe service programs can offer less restrictive, needs-based syringe distribution that does not limit the number of syringes a client can receive. That encourages clients to distribute sterile injection equipment to their peers who inject drugs (also known as secondary exchange). Fewer in-person visits can also help mitigate the effects of limited hours or closure of syringe service program sites that might occur because of COVID-19. Additionally, needs-based distribution models are the most effective at enabling people to use a sterile syringe with every injection.18,19

Recommendations

All Organizations Serving People Who Inject Drugs

People who inject drugs need comprehensive medical care. Providers and organizations serving people who use drugs can collaborate to ensure that people currently or previously injecting drugs, or who are at high risk of drug injection, have access to culturally competent prevention and care services, including during the context of COVID-19.

Recognize that any clinical encounter is an opportunity to provide multiple clinical and public health services for PWID, especially in the context of COVID-19.
Partner with other organizations to provide comprehensive medical care and services, including
Medication for opioid use disorder ((MOUD), also known as medication-assisted treatment, such as buprenorphine, methadone, and naltrexone) or other services for substance use disorder or other mental or behavioral health needs (as appropriate)
Education about safer injection practices and never reusing or sharing needles, syringes, or drug preparation equipment (e.g., cookers, water, filters) for people not yet motivated or able to stop injecting drugs
Screening and treatment for skin and soft tissue and other infections (HIV, HCV, HBV, STIs)
Vaccination against hepatitis A and hepatitis B
Sterile syringes (e.g., prescribe or refer to a syringe services program or to nonprescription sales through retail pharmacies, where legally permissible)
Naloxone (for overdose reversal)
Pre-exposure prophylaxis (PrEP) to prevent HIV acquisition
HIV post-exposure prophylaxis for persons potentially exposed to HIV through sex or injection within the past 72 hours
Counseling about other strategies to reduce risk of HIV transmission or acquisition, including limiting the number of sex partners and using condoms the correct way every time they have sex
Testing for HIV and HCV at least annually
HIV self-testing or use of a home specimen collection kit may be considered particularly in the context of COVID-19
If testing confirms HIV or HCV is present:
Rapidly link to care and treatment for HIV, HCV, or both infections to reduce viral load rapidly, improve patient outcomes, and prevent further transmission; and
Encourage injection partners and sex partners of people with HIV or HCV to get tested.
People who inject drugs can better access the diversity of needed services when services are provided in convenient locations, through mobile service delivery, or when services are co-located and integrated (often referred to as “one-stop shops�?.

Clinical Providers

When patients present with possible complications of injection drug use (e.g., skin, soft tissue, or bloodstream infections; overdose):
Provide screening for substance use disorder;
Recommend and offer HIV, HCV, and STI testing;
Vaccinate against hepatitis A and hepatitis B; and
Offer or refer for substance use disorder treatment, including MOUD.
Report cases of newly diagnosed HIV or HCV to the health department.
Remain alert to, and notify the health department of, increases in or clusters of HIV or HCV diagnoses.
Monitor adherence and offer adherence support for PWID who receive medication for opioid use disorder or treatment for HIV, HCV, or both infections.
Connect patients with community resources, including harm reduction or syringe services programs, to ensure access to sterile syringes and to address other social and behavioral health needs.
If syringe services programs are not available, provide prescriptions for syringes or information about nonprescription pharmacy sales, in accordance with local laws.
Collaborate with public health officials to implement or expand routine opt-out HIV and HCV testing for PWID in settings such as correctional facilities, emergency departments, substance use disorder treatment centers, and community-based medical practices that are frequented by people who inject drugs.
Consult guidance for managing people with HIV who develop COVID-19external icon.
Public Health Officials

Ensure contact tracing for all new HIV diagnoses.
Encourage HIV, HCV, and STI testing of all sex and injection partners and social contacts.
Consider retesting PWID, those engaging in high-risk sexual behavior, and those who have partners with HIV at least annually.
Routinely monitor your public health data to ensure timely identification of:
Recent increases in HIV diagnoses attributed to injection drug use, and
Recent increases in HCV diagnoses, particularly among people younger than 40 years of age.
Remain alert to high rates of or increases in homelessness or unstable housing, injection drug use, overdose events and deaths, admissions for drug treatment, and drug arrests.
Alert community partners to the potential for HIV outbreaks among people who inject drugs.
Work with community partners trusted by PWID to identify and strengthen policies and partnerships to enable rapid response to potential HIV outbreaks. Trusted partners may include those serving people experiencing homelessness or unstable housing, and substance use disorder treatment and recovery programs.
Work with clinical providers in settings frequented by people who inject drugs to implement or expand routine opt-out HIV and HCV testing for PWID. These settings may include correctional facilities, emergency departments, substance use disorder treatment centers, and community-based medical practices.
Implement or increase street-outreach testing or home testing or specimen collection.
Improve access to sterile syringes and injection equipment by establishing syringe services programs; amending policies to offer less restrictive, needs-based, and non-punitive syringe distribution models that promote secondary exchange; or increasing access to nonprescription syringe sales from retail pharmacies, in accordance with local laws.
Establish collaborations to improve coordination of essential services for people who inject drugs with key partners, including:
Clinics funded by the Health Resources and Services Administration’s Ryan White HIV/AIDS Program (RWHAP)external icon and Health Center Programexternal icon, which provide critical access points for health care and support services for people with HIV and people at risk for acquiring HIV
Harm reduction coalitions
Community-based organizations that serve PWID or people experiencing homelessness
Behavioral health providers
Engage with people who currently inject (or formerly injected) drugs as partners in developing recommendations for establishing or expanding essential services for PWID.
Additional Services in the Context of COVID-19

When services are provided in person, guidance is available for minimizing risk of COVID-19 transmission in clinical and field-based settings. When face-to-face services have been disrupted, monitor service delivery and consider alternate means to ensure services reach the needed population.

Consult guidance for delivering specific services in the context of COVID-19, including:
HIV testing
PrEP
Syringe services programs (where legally permissible)
STI clinical servicespdf icon
Substance use disorder treatmentexternal icon
HIV medical care and antiretroviral therapyexternal icon
When PWID need HIV care, discuss the risks and benefits of in-person visits versus telephone or virtual visits in the context of COVID-19. Factors to consider include the extent of local COVID-19 transmission, the health needs that will be addressed during the appointment, and the person’s HIV status (e.g., CD4 cell count, HIV viral load) and other underlying medical conditions. Telephone or virtual visits for routine or non-urgent care and adherence counseling may replace face-to-face encounters.
In the context of COVID-19, communicate options for clients to obtain extended supplies of medications such as antiretroviral therapyexternal icon (ART), PrEP, and PEP through mail order
Clinical and public health encounters with people who inject drugs present additional opportunities to address COVID-19 risks.

To protect themselves and others from COVID-19, provide PWID with access to face masks, hand sanitizer, and education about avoiding close contact and other steps to reduce risk of exposure.
Screen PWID for symptoms of COVID-19. For those with suspected or confirmed COVID-19:
Provide or refer for urgent or non-urgent medical care, if necessary.
Isolate from other people to prevent spreading of infection.
Local health departments, housing authorities, homeless service systems, and healthcare facilities should plan to identify locations to isolate those with known or suspected COVID-19 until they meet the criteria to end isolation.
Consult guidance to assist people experiencing homelessness in the context of COVID-19.
AU  - Centers for Disease Control and Prevention
DB  - Centers for Disease Control and Prevention
DP  - Centers for Disease Control and Prevention
PY  - 2020
SN  - HAN00436
ST  - HAN: Recent HIV Clusters and Outbreaks Across the United States Among People Who Inject Drugs and Considerations During the COVID-19 Pandemic
T2  - CDC Health Alert Network
TI  - HAN: Recent HIV Clusters and Outbreaks Across the United States Among People Who Inject Drugs and Considerations During the COVID-19 Pandemic
UR  - https://emergency.cdc.gov/han/2020/han00436.asp
ID  - 7788841
ER  - 

TY  - JOUR
AB  - A stable or even improved glycemic control was found in adolescents with T1DM using hybrid closed loop system not only during COVID-19 lockdown but also in the weeks after, when daily activities slowly resumed. Although the slowing down of routine daily activities might still have an influence, we believe that the continuation of the health care professional assistance through telemedicine during lockdown might have led to a "dragging effect" in these patients also after its suspension. Copyright © 2020 Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd
AD  - (Ceconi, Barbi) University of Trieste, Trieste, Italy (Barbi, Tornese) Institute for maternal and child health IRCCS Burlo Garofolo, Trieste, Italy
G. Tornese, Institute for maternal and child health IRCCS Burlo Garofolo, Trieste, Italy. E-mail: gianluca.tornese@burlo.trieste.it
AN  - 2006851969
AU  - Ceconi, V.
AU  - Barbi, E.
AU  - Tornese, G.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.1111/1753-0407.13110
DP  - Ovid Technologies
KW  - adolescent
coronavirus disease 2019
daily life activity
glycemic control
health care personnel
human
insulin dependent diabetes mellitus
letter
quarantine
suspension
telemedicine
LA  - English
M3  - Letter
N1  - Using Smart Source Parsing
Date of Publication: 2020
PY  - 2020
SN  - 1753-0393
1753-0407
ST  - Glycemic control in type 1 diabetes mellitus and COVID-19 lockdown: What comes after a "quarantine"?
T2  - Journal of Diabetes
TI  - Glycemic control in type 1 diabetes mellitus and COVID-19 lockdown: What comes after a "quarantine"?
UR  - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1753-0407
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2006851969
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:32909344&id=10.1111%2F1753-0407.13110&issn=1753-0393&isbn=&volume=&issue=&spage=&pages=&date=2020&title=Journal+of+Diabetes&atitle=Glycemic+control+in+type+1+diabetes+mellitus+and+COVID-19+lockdown%3A+What+comes+after+a+%22quarantine%22%3F&aulast=Ceconi&pid=%3Cauthor%3ECeconi+V.%2CBarbi+E.%2CTornese+G.%3C%2Fauthor%3E&%3CAN%3E2006851969%3C%2FAN%3E&%3CDT%3ELetter%3C%2FDT%3E
ID  - 7783053
ER  - 

TY  - JOUR
AB  - We examined whether scientific reasoning is associated with health-related beliefs and behaviors over and above general analytic thinking ability in the general public (N�?�?83, aged 18-84). Health-related beliefs included: anti-vaccination attitudes, COVID-19 conspiracy beliefs, and generic health-related epistemically suspect beliefs. Scientific reasoning correlated with generic pseudoscientific and health-related conspiracy beliefs and COVID-19 conspiracy beliefs. Crucially, scientific reasoning was a stronger independent predictor of unfounded beliefs (including anti-vaccination attitudes) than general analytic thinking was; however, it had a more modest role in health-related behaviors.
AD  - Institute of Experimental Psychology, Centre of Social and Psychological Sciences, Slovak Academy of Sciences, Bratislava, Slovakia.
AN  - 33016131
AU  - Čavojov֙, V.
AU  - Šrol, J.
AU  - Ballov֙ Miku�Qkov֙, E.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1177/1359105320962266
DP  - NLM
ET  - 2020/10/06
J2  - Journal of health psychology
KW  - Covid-19
COVID-19 conspiracy beliefs
analytic thinking
anti-vaccination attitudes
preventive behavior
scientific reasoning
LA  - eng
N1  - 1461-7277
Čavojov֙, Vladim�Tra
Orcid: 0000-0002-7295-8803
Šrol, Jakub
Ballov֙ Miku�Qkov֙, Eva
Journal Article
England
J Health Psychol. 2020 Oct 4:1359105320962266. doi: 10.1177/1359105320962266.
PY  - 2020
SN  - 1359-1053
SP  - 1359105320962266
ST  - How scientific reasoning correlates with health-related beliefs and behaviors during the COVID-19 pandemic?
T2  - Journal of health psychology
TI  - How scientific reasoning correlates with health-related beliefs and behaviors during the COVID-19 pandemic?
ID  - 7785220
ER  - 

TY  - JOUR
AB  - Introduction The spread of COVID-19 has challenged the paramedic community's ability to provide health care, maintain personal safety, and implement evidence informed decisions and programs. The study objective was to examine the published literature related to paramedicine and pandemics. Methods A rapid review of research derived from an existing broad database of literature generated between 2006 and 2019 was used. We conducted a targeted secondary search of this database to identify studies of pandemics in paramedicine contexts and included three levels of screening. We used content analysis to identify broad themes and subthemes, and provide summaries and descriptions of each. Results From 54,638 citations, our search identified 24 citations representing eight countries. The most common method of enquiry was cross-sectional survey (n=10). Five broad themes (and 15 subthemes) were identified: general planning and preparedness (impact to paramedic service operations, roles and responsibilities, communication centre preparedness, paramedic service preparedness, training); workforce (availability of personal protective equipment, safety of family, perception of risk, trust in the organisation); ethics (duty, resource allocation); (triage (needless exposure to infection, transmission of disease); and vaccination (vaccination information, organisational readiness). Conclusion The evidence base describes the importance of pandemic planning and preparedness for emergency medical services and integrating these activities into broader public health and healthcare system plans. Although this rapid review provides a foundation to support response plans and research, it is considered 'just in time' for the evolving pandemic, and further work understanding research in paramedicine and pandemics is recommended. Copyright © 2020, Paramedics Australasia. All rights reserved.
AD  - (Cavanagh, Taplin, Hall, Weiss, Blanchard) Alberta Health Services, Emergency Medical Services, AB, Canada (Cavanagh, Taplin, Blanchard) Cumming School of Medicine, Department of Community Health Sciences, University of Calgary, AB, Canada (Tavares) The Wilson Centre, Department of Medicine, University of Toronto, Canada (Tavares) University Health Network York Region Paramedic Services, Community Health Services Department, Canada
N. Cavanagh, Alberta Health Services, Emergency Medical Services, AB, Canada. E-mail: nicola.cavanagh@ahs.ca N. Cavanagh, Cumming School of Medicine, Department of Community Health Sciences, University of Calgary, AB, Canada. E-mail: nicola.cavanagh@ahs.ca
AN  - 2005108532
AU  - Cavanagh, N.
AU  - Tavares, W.
AU  - Taplin, J.
AU  - Hall, C.
AU  - Weiss, D.
AU  - Blanchard, I.
C1  - 10/6/2020
DA  - 06 Jan
DB  - Embase
DO  - http://dx.doi.org/10.33151/ajp.17.826
DP  - Ovid Technologies
KW  - Emergency medical services
Pandemic
Paramedicine
Rapid review
clinical article
content analysis
emergency health service
ethics
health care system
perception
protective equipment
public health
resource allocation
responsibility
review
trust
vaccination
workforce
LA  - English
M3  - Review
PY  - 2020
SN  - 2202-7270
SP  - 1-12
ST  - A rapid review of pandemic studies in paramedicine
T2  - Australasian Journal of Paramedicine
TI  - A rapid review of pandemic studies in paramedicine
UR  - https://ajp.paramedics.org/index.php/ajp/article/view/826/1017
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005108532
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.33151%2Fajp.17.826&issn=2202-7270&isbn=&volume=17&issue=&spage=1&pages=1-12&date=2020&title=Australasian+Journal+of+Paramedicine&atitle=A+rapid+review+of+pandemic+studies+in+paramedicine&aulast=Cavanagh&pid=%3Cauthor%3ECavanagh+N.%2CTavares+W.%2CTaplin+J.%2CHall+C.%2CWeiss+D.%2CBlanchard+I.%3C%2Fauthor%3E&%3CAN%3E2005108532%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 17
ID  - 7783020
ER  - 

TY  - JOUR
AB  - This paper intends to analyze how Afro-Brazilian religious minorities (like Candomblé and Umbanda) are responding to the Covid-19 crisis in Brazil both at a religious and political level. Drawing a comparison between the reactions of Neo-Pentecostal churches and Afro-Brazilian religions, we will describe how the pandemic outbreak and the social distancing measures allowed Afro-religious practitioners to occupy new online spaces. In doing so, these religions found new modalities of practising rituals and transmitting sacred knowledge in the digital world. Despite the fundamental importance of bodily engagement in these religious expressions, Candomblé and Umbanda practitioners are increasing their presence online through producing different types of pedagogical, educational and ritual contents. While on the one hand, this new content aims at promoting social distancing and sanitary precautionary measures, on the other hand, it involves a restructuring of the dynamics of legitimation and power that are present in Afro-religious social structures. We will analyze these changing dynamics as consequences of the “crisis of the body�?that resulted from the lockdown measures. © 2020, Springer Nature Switzerland AG.
AD  - Département de la Recherche et de l’Enseignement, Musée du quai Branly, Paris, France
Instituto de Humanidades, Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB), Redenção, CE, Brazil
AU  - Capponi, G.
AU  - Carneiro Araújo, P.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s41603-020-00121-3
J2  - Int. J. Lat. Am. Religions
KW  - Afro-Brazilian religions
Body and religion
Covid-19
Neo-Pentecostalism
Religion and media
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Capponi, G.; Département de la Recherche et de l’Enseignement, Musée du quai BranlyFrance; email: giovanna.capponi@gmail.com
References: Beliso-De Jesús, A.M., (2015) Electric Santer�Ta. Racial and sexual assemblages of transnational religion, , Columbia University Press, New York; Capponi, G., Carneiro Araújo, P., Eu me declaro�? Di֙logo sobre transformações, autodefinições e reivindicações pol�Tticas nos cultos afro brasileiros (2015) II Simp�Qsio Sudeste ABHR: G�^nero E religião: Viol�^ncia, Fundamentalismos E pol�Ttica, , PUC/SP: São Paulo; Carneiro, E., (1969) Candomblés Da Bahia, , Rio de Janeiro, Tecnoprint; Carneiro Araújo, P., Ekodidé no samb�Qdromo: segredo ritual, candomblé e espaço público no carnaval paulistano (2016) Áltera �?Revista de Antropologia, 2 (3), pp. 13-36; (2008) Entre A Oralidade E A Escrita: A Etnografia Nos candomblés Da Bahia, , Salvador, Edufba; Gonçalves, D.S.V., Neopentecostalismo e religiões afrobrasileiras: Significado do ataque aos s�Tmbolos da herança religiosa africana no Brasil contemporâneo (2007) Mana, 13 (1), pp. 207-237; Grossi, A., (2020) Religion On Lockdown: On the Articulation of Vodu, Media and Science. Religious Matters in an Entangled World, , https://religiousmatters.nl/religion-on-lockdown-on-the-articulation-of-vodu-media-and-science/, . Accessed 28 Sep 2020; Hartikainen, E.I., (2020) Religion, law, and Bolsonaro’s decree on essential services.�? , https://culanth.org/fieldsights/religion-law-and-bolsonaros-decree-on-essential-services, Covid-19, Fieldsights, May 12, . Last accessed 20 Jun 2020; Kramer, W.E., Spectacle and the staging of power in Brazilian Neo Pentecostalism (2005) Latin American Perspectives, 32 (1), pp. 95-120; Mariano, R., Expansão Pentecostal no Brasil: O Caso da Igreja Universal (2004) Estudos Avançados, 18 (52), pp. 121-138; Martini, M., Interdenominational cooperation in religious new media projects: The case of the Christian Media Center (2020) International Journal of Latin American Religions, 4, pp. 137-147. , 2020; Atwood, M.M., (2002) Living Santer�Ta: Rituals and Experiences in an Afro-Cuban Religion, , Washington DC, Smithsonian Books; Meyer, B., (2009) Aesthetic formations: media, religion, and the senses, , Palgrave Macmillian, New York; Meyer, B., Mediation and immediacy: sensational forms, semiotic ideologies and the question of the medium (2011) Soc Anthropol, 19 (1), pp. 23-39; Reinhardt, B., Atmospheric presence: reflections on “mediation�?in the anthropology of religion and technology (2020) Anthropol Q, 93 (1), pp. 1523-1553; Stolow, J., Religion and/as media (2005) Theory Cult Soc, 22 (4), pp. 119-146; Van de Port, M., Moonlight (2020) Mater Relig, 16 (1), pp. 110-112
PY  - 2020
SN  - 25099965 (ISSN)
ST  - Occupying New Spaces: the “Digital Turn�?of Afro-Brazilian Religions During the Covid-19 Outbreak
T2  - International Journal of Latin American Religions
TI  - Occupying New Spaces: the “Digital Turn�?of Afro-Brazilian Religions During the Covid-19 Outbreak
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091732891&doi=10.1007%2fs41603-020-00121-3&partnerID=40&md5=5678584017c9b9c5cd2031e0a84253d0
ID  - 7783311
ER  - 

TY  - JOUR
AB  - INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to an extensive reorganization of the healthcare system in Italy, with significant deferment of the treatment of urology patients. We aimed to assess the impact of deferred treatment during the SARS-CoV-2 pandemic on the need for blood transfusions in 3 Italian urology departments. METHODS: We reviewed hospital chart data on blood transfusions at the urology units of 3 academic centers in the north of Italy from March to April 2020. Data were compared with values from the same time frame in 2019 (March to April 2019). RESULTS: We observed significant reductions of the number of patients admitted to the urology units from March to April 2020 (373 vs. 119) and the number of performed surgeries (242 vs. 938) compared to 2019. Though, the number of transfused blood units was comparable between the 2 years (182 vs. 252), we found a greater mean number of blood units transfused per admission in 2020 (0.49 vs. 0.22; p  0.0001). As a whole, the transfusion rate for hematuria was higher in 2020 than in 2019 (36 vs. 7.9%; p  0.0001). DISCUSSION/CONCLUSION: The observed increased number of blood transfusions needed throughout the SARS-CoV-2 era could have had a negative impact on both patients and the healthcare system. It is possible to speculate that this is the consequence of a delayed diagnosis and deferred treatment of acute conditions.
AD  - Department of Urology, Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi, Varese, Italy, paolo.capogrosso@gmail.com.
Unit of Urology, Division of Experimental Oncology, URI, IRCCS Ospedale San Raffaele, Milan, Italy.
Vita-Salute San Raffaele University, Milan, Italy.
Department of Urology, Ospedale di Circolo e Fondazione Macchi - ASST Sette Laghi, Varese, Italy.
Department of Urology, Papa Giovanni XIII Hospital, Bergamo, Italy.
University of Insubria, Varese, Italy.
University of Bicocca, Milan, Italy.
AN  - 33017835
AU  - Capogrosso, P.
AU  - Candela, L.
AU  - Rossi, P.
AU  - Guarasci, C.
AU  - Muttin, F.
AU  - Roscigno, M.
AU  - Chianese, R.
AU  - Santoleri, L.
AU  - Tassara, M.
AU  - Carcano, G.
AU  - Naspro, R.
AU  - Da Pozzo, L.
AU  - Montorsi, F.
AU  - Salonia, A.
AU  - Dehò, F.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1159/000511651
DP  - NLM
ET  - 2020/10/06
J2  - Urologia internationalis
KW  - Bleeding
Blood transfusion
Covid-19
Hematuria
LA  - eng
N1  - 1423-0399
Capogrosso, Paolo
Candela, Luigi
Rossi, Piercarlo
Guarasci, Cristian
Muttin, Fabio
Roscigno, Marco
Chianese, Rosa
Santoleri, Luca
Tassara, Michela
Carcano, Giulio
Naspro, Richard
Da Pozzo, Luigi
Montorsi, Francesco
Salonia, Andrea
Dehò, Federico
Journal Article
Switzerland
Urol Int. 2020 Oct 5:1-4. doi: 10.1159/000511651.
PY  - 2020
SN  - 0042-1138
SP  - 1-4
ST  - Increased Use of Blood Transfusions to Manage Urological Conditions during the COVID-19 Pandemic
T2  - Urologia internationalis
TI  - Increased Use of Blood Transfusions to Manage Urological Conditions during the COVID-19 Pandemic
ID  - 7785116
ER  - 

TY  - JOUR
AB  - OBJECTIVES: The aim of this narrative review was to collect all findings from literature about oral signs and symptoms of COVID-19, in order to draw a picture of oral involvement of this challenging viral infection, to help oral professionals in a better triage and early diagnosis. MATERIAL AND METHODS: The search for international literature was made including articles written in English and reporting about oral manifestations in patients with a diagnosis of COVID-19. The publication time was limited to 2019 and 2020, up to May 20, 2020. A narrative review was performed. RESULTS: Twenty-three articles were included in this review. Three different oral manifestations were found: taste alteration, oral blister and ulcers, and oral lesions associated with Kawasaki-like diseases (erythema, bleeding of lips, "strawberry tongue"). The higher expression of Angiotensin-converting enzyme 2 in the oral cavity and in endothelial cells might be responsible for oral manifestation and the major report of signs and symptoms in the occidental countries. CONCLUSIONS: Detecting oral signs and symptoms of COVID-19 could be useful to perform a better preliminary triage in dental setting, and in recognizing possible early manifestations of the disease. However, considering the outbreak of COVID-19 and the consequent difficulty of undergoing oral examinations, the oral manifestations might be misdiagnosed; then, we would encourage oral professionals to perform other studies about this topic.
AD  - Section of Dentistry and Maxillofacial Surgery, Department of Surgical Sciences, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
Section of Ears, Nose and Throat (ENT), Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, Verona, Italy.
AN  - 33021087
AU  - Capocasale, G.
AU  - Nocini, R.
AU  - Faccioni, P.
AU  - Donadello, D.
AU  - Bertossi, D.
AU  - Albanese, M.
AU  - Zotti, F.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1002/cre2.332
DP  - NLM
ET  - 2020/10/07
J2  - Clinical and experimental dental research
KW  - Covid-19
dysgeusia
oral blister
oral disease
LA  - eng
N1  - 2057-4347
Capocasale, Giorgia
Orcid: 0000-0001-8578-8041
Nocini, Riccardo
Faccioni, Paolo
Donadello, Dario
Bertossi, Dario
Albanese, Massimo
Zotti, Francesca
Journal Article
Review
United States
Clin Exp Dent Res. 2020 Oct 5. doi: 10.1002/cre2.332.
PY  - 2020
SN  - 2057-4347
ST  - How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease
T2  - Clinical and experimental dental research
TI  - How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease
ID  - 7784959
ER  - 

TY  - JOUR
AB  - After the COVID-19 worldwide spread, evidence suggested a vast diffusion of negative consequences on people's mental health. Together with depression and sleep difficulties, anxiety symptoms seem to be the most diffused clinical outcome. The current contribution aimed to examine attentional bias for virus-related stimuli in people varying in their degree of health anxiety (HA). Consistent with previous literature, it was hypothesized that higher HA would predict attentional bias, tested using a visual dot-probe task, to virus-related stimuli. Participants were 132 Italian individuals that participated in the study during the lockdown phase in Italy. Results indicated that the HA level predicts attentional bias toward virus-related objects. This relationship is double mediated by the belief of contagion and by the consequences of contagion as assessed through a recent questionnaire developed to measure the fear for COVID-19. These findings are discussed in the context of cognitive-behavioral conceptualizations of anxiety suggesting a risk for a loop effect. Future research directions are outlined.
AD  - Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti-Pescara, 66100, Chieti Scalo, Italy. loreta.cannito@unich.it.
Department of Neuroscience, Imaging and Clinical Sciences, University G. D'Annunzio of Chieti-Pescara, 66100, Chieti Scalo, Italy.
Department of Psychological Sciences, Health and Territory, University G. D'Annunzio of Chieti-Pescara, 66100, Chieti Scalo, Italy.
AN  - 33020567
AU  - Cannito, L.
AU  - Di Crosta, A.
AU  - Palumbo, R.
AU  - Ceccato, I.
AU  - Anzani, S.
AU  - La Malva, P.
AU  - Palumbo, R.
AU  - Di Domenico, A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1038/s41598-020-73599-8
DP  - NLM
ET  - 2020/10/07
IS  - 1
J2  - Scientific reports
LA  - eng
N1  - 2045-2322
Cannito, Loreta
Di Crosta, Adolfo
Palumbo, Rocco
Ceccato, Irene
Anzani, Stefano
La Malva, Pasquale
Palumbo, Riccardo
Di Domenico, Alberto
Journal Article
England
Sci Rep. 2020 Oct 5;10(1):16476. doi: 10.1038/s41598-020-73599-8.
PY  - 2020
SN  - 2045-2322
SP  - 16476
ST  - Health anxiety and attentional bias toward virus-related stimuli during the COVID-19 pandemic
T2  - Scientific reports
TI  - Health anxiety and attentional bias toward virus-related stimuli during the COVID-19 pandemic
VL  - 10
ID  - 7785021
ER  - 

TY  - JOUR
AB  - OBJECTIVES: This study aimed to determine the prevalence of respiratory virus infections, including SARS-CoV-2, during December 2019 - March 2020, in a tertiary care hospital-based survey in Parma (Northern Italy). METHODS: A total of 906 biological samples of respiratory tract were analyzed by both conventional (including culture) and molecular assays targeting SARS-CoV-2 and the other respiratory viruses nucleic acids. RESULTS: 474 samples (52.3%) were positive for at least one virus for a total of 583 viruses detected. Single infections were detected in 380 (80.2%) samples and mixed infections were detected in 94 (19.8%). RSV (138/583: 23.7%) and RV (130/583: 22.3%) were the most common viruses identified, followed by SARS-CoV2 (82/583: 14.1%). RSV predominates until February with 129 detections and drastically decreases in March to 9 detections. SARS-CoV-2 absent in our area until February 26, in just over a month reached 82 detections. SARS-CoV-2 was found in mixed infections only in 3 cases all observed in children younger than one year old. CONCLUSIONS: This study showed a completely different trend between SARS-CoV-2 and the "common" respiratory viruses that have seen children most affected without distinction of sex, as opposed to SARS-CoV-2 that have seen adult males the most infected.
AD  - Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: adriana.calderaro@unipr.it.
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: flora.deconto@unipr.it.
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: mirko.buttrini@unipr.it.
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: giovanna.piccolo@unipr.it.
Unit of Clinical Virology, University Hospital of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: smontecchini@ao.pr.it.
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: clara.maccari@unipr.it.
Unit of Clinical Microbiology, University Hospital of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: mmartinelli@ao.pr.it.
Unit of Clinical Microbiology, University Hospital of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: adimaio@ao.pr.it.
Unit of Clinical Virology, University Hospital of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: fferraglia@ao.pr.it.
Unit of Clinical Virology, University Hospital of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: fpinardi@ao.pr.it.
Unit of Clinical Virology, University Hospital of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: pmontagna@ao.pr.it.
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: mariacristina.arcangeletti@unipr.it.
Department of Medicine and Surgery, University of Parma, Viale A. Gramsci 14, 43126 Parma, Italy. Electronic address: carlo.chezzi@unipr.it.
AN  - 33017694
AU  - Calderaro, A.
AU  - De Conto, F.
AU  - Buttrini, M.
AU  - Piccolo, G.
AU  - Montecchini, S.
AU  - Maccari, C.
AU  - Martinelli, M.
AU  - Di Maio, A.
AU  - Ferraglia, F.
AU  - Pinardi, F.
AU  - Montagna, P.
AU  - Arcangeletti, M. C.
AU  - Chezzi, C.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.ijid.2020.09.1473
DP  - NLM
ET  - 2020/10/06
J2  - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
KW  - Cultivation
Diagnosis
Epidemiology
Molecular assays
Pandemia
Respiratory viruses
SARS-CoV-2
LA  - eng
N1  - 1878-3511
Calderaro, Adriana
De Conto, Flora
Buttrini, Mirko
Piccolo, Giovanna
Montecchini, Sara
Maccari, Clara
Martinelli, Monica
Di Maio, Alan
Ferraglia, Francesca
Pinardi, Federica
Montagna, Paolo
Arcangeletti, Maria Cristina
Chezzi, Carlo
Journal Article
Canada
Int J Infect Dis. 2020 Oct 2:S1201-9712(20)32189-5. doi: 10.1016/j.ijid.2020.09.1473.
PY  - 2020
SN  - 1201-9712
ST  - Human respiratory viruses, including SARS-CoV-2, circulating in the winter season 2019-2020 in Parma, Northern Italy
T2  - International journal of infectious diseases : IJID : official publication of International Society for Infectious Diseases
TI  - Human respiratory viruses, including SARS-CoV-2, circulating in the winter season 2019-2020 in Parma, Northern Italy
ID  - 7785122
ER  - 

TY  - JOUR
AB  - School closures appear to slow the spread of the virus, but for many children the health ramifications are far broader.
AD  - Jessica Bylander (jbylander@projecthope.org) is a senior editor and correspondent at Health Affairs, in Bethesda, Maryland.
AN  - 33017239
AU  - Bylander, J.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1377/hlthaff.2020.01576
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Health affairs (Project Hope)
LA  - eng
N1  - 1544-5208
Bylander, Jessica
News
United States
Health Aff (Millwood). 2020 Oct;39(10):1668-1671. doi: 10.1377/hlthaff.2020.01576.
PY  - 2020
SN  - 0278-2715
SP  - 1668-1671
ST  - How COVID-19 Threatens The Safety Net For US Children
T2  - Health affairs (Project Hope)
TI  - How COVID-19 Threatens The Safety Net For US Children
VL  - 39
ID  - 7785148
ER  - 

TY  - JOUR
AN  - 33010809
AU  - Burki, T. K.
C1  - 10/6/2020
C2  - PMC7529387
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/s2213-2600(20)30460-4
DP  - NLM
ET  - 2020/10/05
J2  - The Lancet. Respiratory medicine
LA  - eng
N1  - 2213-2619
Burki, Talha Khan
Journal Article
Lancet Respir Med. 2020 Oct 1:S2213-2600(20)30460-4. doi: 10.1016/S2213-2600(20)30460-4.
PY  - 2020
SN  - 2213-2600 (Print)
2213-2600
ST  - Completion of clinical trials in light of COVID-19
T2  - Lancet Respiratory medicine
TI  - Completion of clinical trials in light of COVID-19
ID  - 7785726
ER  - 

TY  - JOUR
AB  - Coronavirus Disease 2019 (COVID-19) symptoms are highly various in each patient. CXR are routinely used to monitor the disease progression. However, it is not known whether chest X-Ray (CXR) is a good modality to assess COVID-19 pneumonia.Male, 55 years-old, with pneumonia caused by COVID-19. Discordance was found between patient's clinical status and CXR lesion. On the 7th day of symptoms, patient was clinically well despite severe lesion shown on CXR. On the following day, patient clinically deteriorated despite the improvement on CXR lesion.Improvement of CXR does not always correlate well with patient's clinical status. Clinician have to be careful when using CXR to monitor patient with COVID-19 pneumonia.
AD  - Department of Pulmonology, Faculty of Medicine Universitas Indonesia - Persahabatan Hospital, Jakarta, Indonesia. erlina_burhan@yahoo.com.
AN  - 33020341
AU  - Burhan, E.
AU  - Agustin, H.
AU  - Susanto, A. D.
AU  - Dharmawan, Inip
AU  - Meyer, M.
AU  - Rogayah, R.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
asymptomatic transmission
chest X-ray
LA  - eng
N1  - Burhan, Erlina
Agustin, Heidy
Susanto, Agus Dwi
Dharmawan, Ibrahim Nur Insan Putra
Meyer, Markus
Rogayah, Rita
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):297-298.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 297-298
ST  - Discordance Between Clinical Status and Chest X-Ray (CXR) in COVID-19 Patient with Asymptomatic Transmission in Jakarta
T2  - Acta medica Indonesiana
TI  - Discordance Between Clinical Status and Chest X-Ray (CXR) in COVID-19 Patient with Asymptomatic Transmission in Jakarta
VL  - 52
ID  - 7785029
ER  - 

TY  - JOUR
AB  - As the COVID-19 pandemic swept through the United States, our heath-system mobilized clinical pharmacy services to address critical clinical medication management needs. Reinforcing recommended medication management strategies for clinical pharmacists was key to successful implementation. Best practice strategies include converting patients from intravenous (IV) to oral medication, transitioning to IV push medication administration, evaluating standard medication administration timing, reviewing metered dose inhaler (MDI) and nebulizer utilization, using alternatives for medications in short supply, reviewing coronavirus disease COVID-19 treatment recommendations, reviewing COVID-19 patient care on interdisciplinary rounds, de-prescribing and de-escalating to eliminate unnecessary medications, and assessing for appropriate venous thromboembolism prophylaxis. These strategies served to help protect medication supply, reduce number of staff entries into patient rooms to conserve personal protective equipment, limit nursing time in patient rooms to reduce COVID-19 exposure risk, and to conserve compounding supplies. Here we present example medication management guidance as used by a large healthcare system during the COVID-19 pandemic.
AD  - HCA Holdings Inc, Nashville, TN, USA.
AN  - 33016180
AU  - Burgess, L. H.
AU  - Cooper, M. K.
AU  - Wiggins, E. H.
AU  - Miller, K. M.
AU  - Murray, E.
AU  - Harris, S.
AU  - Kramer, J. S.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/0897190020961655
DP  - NLM
ET  - 2020/10/06
J2  - Journal of pharmacy practice
KW  - Covid-19
guidance
medication management
pharmacist
LA  - eng
N1  - 1531-1937
Burgess, L Hayley
Cooper, Mandelin K
Wiggins, Elizabeth H
Miller, Karla M
Murray, Edward
Harris, Scott
Orcid: 0000-0003-1763-5291
Kramer, Joan S
Journal Article
United States
J Pharm Pract. 2020 Oct 5:897190020961655. doi: 10.1177/0897190020961655.
PY  - 2020
SN  - 0897-1900
SP  - 897190020961655
ST  - Utilizing Pharmacists to Optimize Medication Management Strategies During the COVID-19 Pandemic
T2  - Journal of pharmacy practice
TI  - Utilizing Pharmacists to Optimize Medication Management Strategies During the COVID-19 Pandemic
ID  - 7785213
ER  - 

TY  - JOUR
AB  - Lymphocytopenia during the COVID-19 has been associated with fatality. We tested whether pre-existing lymphocytopenia reported prior to any possible exposure to SARS-COV2 (from 2010 to 2019) was associated with fatality. Using all patients diagnosed on testing in a single regional laboratory, we identified 1137 subjects with PCR positive for SARS-COV2 and at least one available complete blood count from the decade prior to any possible exposure to the virus. Bivariate analysis indicated an association between pre-existing lymphocytopenia (defined as absolute lymphocyte count &amp;lt;0.9x109 /L) and fatality (18% versus 4%). Furthermore, a logistic regression model, accounting for both patient age and number of blood counts obtained, indicated the subjects with pre-existing lymphocytopenia were 1.4 times as likely to die. Because the absolute lymphocyte count is almost universally available and easily interpreted, this biomarker of the risk of fatality could be widely useful.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo external fundingAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:University of Rochester Research Subjects Review Board determined this project to be exempt from review.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.Yesavailable from the corresponding author
AU  - Burack, Richard
AU  - Rock, Philip
AU  - Burtoon, David
AU  - Cai, Xueya
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20200931
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20200931
ST  - Association of Pre-COVID-19 Lymphocytopenia with Fatality (preprint)
T2  - medRxiv
TI  - Association of Pre-COVID-19 Lymphocytopenia with Fatality (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20200931.abstract
ID  - 7788889
ER  - 

TY  - JOUR
AB  - COVID�?9, caused by the coronavirus SARS‐CoV�?, has become pandemic. A further level of complexity opens up as soon as we look at diseases whose pathogenesis and therapy involve different immunological signaling pathways, which are potentially affected by COVID�?9. Medical treatments must often be reassessed and questioned in connection with this infection.This article summarizes the current knowledge of COVID�?9 in the light of major dermatological and allergological diseases. It identifies medical areas lacking sufficient data and draws conclusions for the management of our patients during the pandemic. We focus on common chronic inflammatory skin diseases with complex immunological pathogenesis: psoriasis, eczema including atopic dermatitis, type I allergies, autoimmune blistering and inflammatory connective tissue diseases, vasculitis, and skin cancers. Since several other inflammatory skin diseases display related or comparable immunological reactions, clustering of the various inflammatory dermatoses into different disease patterns may help with therapeutic decisions. Thus, following these patterns of skin inflammation, our review may supply treatment recommendations and thoughtful considerations for disease management even beyond the most frequent diseases discussed here.
AD  - Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany; Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen, Germany ; Department of Dermatology, University Hospital Carl Gustav Carus, Germany ; Department of Dermatology, University Hospital Magdeburg, Germany ; Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany ; Department of Dermatology, Philipps University, Marburg, Germany ; Department of Dermatology, University Hospital Cologne, Germany ; Translational Research in Inflammatory Skin Diseases, IVDP, University Medical Center Hamburg‐Eppendorf, Germany ; Department of Dermatology, University of Lübeck, Germany; Lübeck Institute for Experimental Dermatology (LIED), University of Lübeck, Lübeck, Germany ; Department of Dermatology, FAU Erlangen‐Nuremberg and University Hospital Erlangen, German Center Immunotherapy (DZI), Erlangen, Germany ; Department of Dermatology and Venereology, University Hospital Halle‐Wittenberg, Halle (Saale), Germany ; Institute of Environmental Medicine, UNIKA‐T Augsburg, Technical University Munich and Helmholtz‐Zentrum Munich, German Research Center for Environmental Health, Germany; Outpatient Clinic for Environmental Medicine, University Hospital Augsburg, Germany ; Division of Immunodermatology and Allergy Research, Department of Dermatology and Allergy, Hannover Medical School, Germany ; Department of Dermatology and Allergology, University Medical Center, Friedrich Wilhelm University, Bonn, Germany ; Division of Allergy and Immunology, Department of Dermatology, Venereology and Allergology, Charité �?Universitätsmedizin Berlin, Germany ; Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Germany; Lower Saxony Institute of Occupational Dermatology, University Medical Center Göttingen, Germany
AN  - 2448415357
AU  - Buhl, Timo
AU  - Beissert, Stefan
AU  - Gaffal, Evelyn
AU  - Goebeler, Matthias
AU  - Hertl, Michael
AU  - Mauch, Cornelia
AU  - Reich, Kristian
AU  - Schmidt, Enno
AU  - Schön, Michael P.
AU  - Sticherling, Michael
AU  - Sunderkötter, Cord
AU  - Claudia, Traidl‐Hoffmann
AU  - Werfel, Thomas
AU  - Dagmar, Wilsman‐Theis
AU  - Worm, Margitta
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/ddg.14195
DP  - ProQuest Central
IS  - 8
KW  - Medical Sciences--Dermatology And Venereology
Coronaviruses
Connective tissues
Medical treatment
Vasculitis
Pandemics
Connective tissue diseases
Atopic dermatitis
Skin diseases
Immunology
Severe acute respiratory syndrome coronavirus 2
COVID-19
Pathogenesis
Eczema
Psoriasis
LA  - English
N1  - Copyright - © 2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SN  - 16100379
SP  - 815-824
ST  - COVID�?9 and implications for dermatological and allergological diseases
T2  - Journal der Deutschen Dermatologischen Gesellschaft
TI  - COVID�?9 and implications for dermatological and allergological diseases
UR  - https://www.proquest.com/docview/2448415357?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=COVID%E2%80%9019+and+implications+for+dermatological+and+allergological+diseases&title=Journal+der+Deutschen+Dermatologischen+Gesellschaft&issn=16100379&date=2020-08-01&volume=18&issue=8&spage=815&au=Buhl%2C+Timo%3BBeissert%2C+Stefan%3BGaffal%2C+Evelyn%3BGoebeler%2C+Matthias%3BHertl%2C+Michael%3BMauch%2C+Cornelia%3BReich%2C+Kristian%3BSchmidt%2C+Enno%3BSch%C3%B6n%2C+Michael+P%3BSticherling%2C+Michael%3BSunderk%C3%B6tter%2C+Cord%3BClaudia+Traidl%E2%80%90Hoffmann%3BWerfel%2C+Thomas%3BDagmar+Wilsman%E2%80%90Theis%3BWorm%2C+Margitta&isbn=&jtitle=Journal+der+Deutschen+Dermatologischen+Gesellschaft&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fddg.14195
VL  - 18
ID  - 7784912
ER  - 

TY  - JOUR
AB  - ZusammenfassungDie durch das Coronavirus SARS‐CoV�? verursachte Krankheit COVID�?9 hat sich zu einer Pandemie entwickelt. Bei der Betrachtung von dermatologischen und allergologischen Krankheiten, die potenziell von COVID�?9 betroffen sind, stehen wir vor komplexen Herausforderungen, die Pathogenese und Beeinflussung verschiedener immunologischer Signalwege einschließen. Medizinische Behandlungen müssen daher im Zusammenhang mit dieser Infektion oft neu bewertet und in Frage gestellt werden.Dieser Übersichtsartikel fasst den aktuellen Wissensstand zu COVID�?9 hinsichtlich der wichtigsten dermatologischen und allergologischen Erkrankungen zusammen. Es werden aber auch die medizinischen Bereiche beschrieben, für die keine ausreichenden Daten vorliegen. Unter Zusammenfassung der publizierten Daten und grundsätzlicher pathophysiologischer Überlegungen werden hier Schlussfolgerungen für das Management unserer Patienten während der Pandemie gezogen. Wir konzentrieren uns auf häufige Hauterkrankungen mit komplexer immunologischer Pathogenese: Psoriasis, Ekzeme einschließlich atopischer Dermatitis, Typ‐I‐Allergien, blasenbildende Autoimmundermatosen, Kollagenosen, Vaskulitiden und Hautkrebserkrankung. Da viele weitere Hauterkrankungen verwandte oder vergleichbare immunologische Reaktionsmuster aufweisen, können pathophysiologisch ähnliche entzündliche Dermatosen möglicherweise auch mit ähnlichen therapeutischen Überlegungen und Schlussfolgerungen während der Pandemie behandelt werden. Daher soll diese Übersicht Behandlungsempfehlungen auf der Basis bisher publizierter Daten und Empfehlungen zu Therapieentscheidungen auch über die hier diskutierten, häufigsten Erkrankungen hinaus liefern.
AD  - Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Göttingen, Deutschland; Niedersächsisches Institut für Berufsdermatologie, Universitätsklinikum Göttingen, Deutschland ; Klinik für Dermatologie, Universitätsklinikum Carl Gustav Carus, Deutschland ; Klinik für Dermatologie, Universitätsklinikum Magdeburg, Deutschland ; Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinik Würzburg, Deutschland ; Klinik für Dermatologie, Philipps‐Universität, Marburg, Deutschland ; Klinik für Dermatologie, Universitätsklinik Köln, Deutschland ; Translational Research in Inflammatory Skin Diseases, IVDP, Universitätsklinikum Hamburg‐Eppendorf, Deutschland ; Klinik für Dermatologie, Universität zu Lübeck, Deutschland; Lübecker Institut für Experimentelle Dermatologie (LIED), Universität zu Lübeck, Deutschland ; Klinik für Dermatologie, FAU Erlangen‐Nürnberg und Universitätsklinikum Erlangen, Deutsches Zentrum für Immuntherapie (DZI), Erlangen, Deutschland ; Klinik für Dermatologie und Venerologie, Universitätsklinikum Halle‐Wittenberg, Deutschland ; Institut für Umweltmedizin, UNIKA‐T Augsburg, Technische Universität München und Helmholtz Zentrum München, Deutsches Forschungszentrum für Gesundheit und Umwelt, Deutschland; Ambulanz für Umweltmedizin, Universitätsklinikum Augsburg, Deutschland ; Abteilung für Immundermatologie und Allergieforschung, Klinik für Dermatologie und Allergologie, Medizinische Hochschule Hannover, Deutschland ; Klinik für Dermatologie und Allergologie, Universitätsklinikum, Friedrich‐Wilhelms‐Universität, Bonn, Deutschland ; Abteilung für Allergologie und Immunologie, Klinik für Dermatologie, Venerologie und Allergologie, Charité �?Universitätsmedizin Berlin, Deutschland ; Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Göttingen, Deutschland; Niedersächsisches Institut für Berufsdermatologie, Universitätsklinikum Göttingen, Deutschland
AN  - 2448415579
AU  - Buhl, Timo
AU  - Beissert, Stefan
AU  - Gaffal, Evelyn
AU  - Goebeler, Matthias
AU  - Hertl, Michael
AU  - Mauch, Cornelia
AU  - Reich, Kristian
AU  - Schmidt, Enno
AU  - Schön, Michael P.
AU  - Sticherling, Michael
AU  - Sunderkötter, Cord
AU  - Claudia, Traidl‐Hoffmann
AU  - Werfel, Thomas
AU  - Dagmar, Wilsman‐Theis
AU  - Worm, Margitta
C1  - 10/6/2020
DA  - Aug 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1111/ddg.14195_g
DP  - ProQuest Central
IS  - 8
KW  - Medical Sciences--Dermatology And Venereology
Coronaviruses
Severe acute respiratory syndrome coronavirus 2
COVID-19
Dermatitis
Psoriasis
LA  - English
N1  - Copyright - © 2020. This article is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License�?. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
PY  - 2020
SN  - 16100379
SP  - 815-825
ST  - COVID�?9 und Auswirkungen auf dermatologische und allergologische Erkrankungen
T2  - Journal der Deutschen Dermatologischen Gesellschaft
TI  - COVID�?9 und Auswirkungen auf dermatologische und allergologische Erkrankungen
UR  - https://www.proquest.com/docview/2448415579?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=COVID%E2%80%9019+und+Auswirkungen+auf+dermatologische+und+allergologische+Erkrankungen&title=Journal+der+Deutschen+Dermatologischen+Gesellschaft&issn=16100379&date=2020-08-01&volume=18&issue=8&spage=815&au=Buhl%2C+Timo%3BBeissert%2C+Stefan%3BGaffal%2C+Evelyn%3BGoebeler%2C+Matthias%3BHertl%2C+Michael%3BMauch%2C+Cornelia%3BReich%2C+Kristian%3BSchmidt%2C+Enno%3BSch%C3%B6n%2C+Michael+P%3BSticherling%2C+Michael%3BSunderk%C3%B6tter%2C+Cord%3BClaudia+Traidl%E2%80%90Hoffmann%3BWerfel%2C+Thomas%3BDagmar+Wilsman%E2%80%90Theis%3BWorm%2C+Margitta&isbn=&jtitle=Journal+der+Deutschen+Dermatologischen+Gesellschaft&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1111%2Fddg.14195_g
VL  - 18
ID  - 7784907
ER  - 

TY  - JOUR
AB  - Although antibody response to SARS-CoV-2 can be detected early during the infection, several outstanding questions remain to be addressed regarding the magnitude and persistence of antibody titer against different viral proteins and their correlation with the strength of the immune response. An ELISA assay has been developed by expressing and purifying the recombinant SARS-CoV-2 Spike Receptor Binding Domain (RBD), Soluble Ectodomain (Spike), and full length Nucleocapsid protein (N). Sera from healthcare workers affected by non-severe COVID-19 were longitudinally collected over four weeks, and compared to sera from patients hospitalized in Intensive Care Units (ICU) and SARS-CoV-2-negative subjects for the presence of IgM, IgG and IgA antibodies as well as soluble pro-inflammatory mediators in the sera. Non-hospitalized subjects showed lower antibody titers and blood pro-inflammatory cytokine profiles as compared to patients in Intensive Care Units (ICU), irrespective of the antibodies tested. Noteworthy, in non-severe COVID-19 infections, antibody titers against RBD and Spike, but not against the N protein, as well as pro-inflammatory cytokines decreased within a month after viral clearance. Thus, rapid decline in antibody titers and in pro-inflammatory cytokines may be a common feature of non-severe SARS-CoV-2 infection, suggesting that antibody-mediated protection against re-infection with SARS-CoV-2 is of short duration. These results suggest caution in using serological testing to estimate the prevalence of SARS-CoV-2 infection in the general population.
AD  - Department of Experimental Oncology, European Institute of Oncology IRCCS, via Adamello 16, 20139 Milan, Italy.
Department of Oncology and Hemato-Oncology, University of Milan, via Festa del Perdono 7, 20122 Milan, Italy.
School of Medicine and Surgery, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy.
The Armenise-Harvard Laboratory of Structural Biology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, via Ferrata 9, 27100 Pavia, Italy.
Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Policlinico Milano, Via F. Sforza 35, 20135 Milan, Italy.
Department of Pathophysiology and Transplantation, University of Milan, Via F. Sforza 35, 20135 Milan, Italy.
AN  - 33019628
AU  - Bruni, M.
AU  - Cecatiello, V.
AU  - Diaz-Basabe, A.
AU  - Lattanzi, G.
AU  - Mileti, E.
AU  - Monzani, S.
AU  - Pirovano, L.
AU  - Rizzelli, F.
AU  - Visintin, C.
AU  - Bonizzi, G.
AU  - Giani, M.
AU  - Lavitrano, M.
AU  - Faravelli, S.
AU  - Forneris, F.
AU  - Caprioli, F.
AU  - Pelicci, P. G.
AU  - Natoli, G.
AU  - Pasqualato, S.
AU  - Mapelli, M.
AU  - Facciotti, F.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/jcm9103188
DP  - NLM
ET  - 2020/10/07
IS  - 10
J2  - Journal of clinical medicine
KW  - Covid-19
SARS-CoV-2
anti-SARS-CoV-2 antibodies
pro-inflammatory mediators
LA  - eng
N1  - Bruni, Margherita
Cecatiello, Valentina
Diaz-Basabe, Angelica
Lattanzi, Georgia
Mileti, Erika
Orcid: 0000-0003-0425-5169
Monzani, Silvia
Pirovano, Laura
Rizzelli, Francesca
Visintin, Clara
Bonizzi, Giuseppina
Giani, Marco
Orcid: 0000-0001-8048-2721
Lavitrano, Marialuisa
Orcid: 0000-0003-4852-1318
Faravelli, Silvia
Forneris, Federico
Orcid: 0000-0002-7818-1804
Caprioli, Flavio
Pelicci, Pier Giuseppe
Natoli, Gioacchino
Pasqualato, Sebastiano
Orcid: 0000-0002-9038-7768
Mapelli, Marina
Orcid: 0000-0001-8502-0649
Facciotti, Federica
Orcid: 0000-0002-2541-9428
Journal Article
Switzerland
J Clin Med. 2020 Oct 1;9(10):E3188. doi: 10.3390/jcm9103188.
PY  - 2020
SN  - 2077-0383 (Print)
2077-0383
ST  - Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers
T2  - Journal of clinical medicine
TI  - Persistence of Anti-SARS-CoV-2 Antibodies in Non-Hospitalized COVID-19 Convalescent Health Care Workers
VL  - 9
ID  - 7785092
ER  - 

TY  - JOUR
AB  - OBJECTIVES: To assess inter-reader agreements and diagnostic accuracy of chest CT to identify COVID-19 pneumonia in patients with intermediate clinical probability during an acute disease outbreak. METHODS: From March 20 to April 8, 319 patients (mean age 62.3 years old) consecutive patients with an intermediate clinical probability of COVID-19 pneumonia underwent a chest CT scan. Two independent chest radiologists blinded to clinical information and RT-PCR results retrospectively reviewed and classified images on a 1-5 confidence level scale for COVID-19 pneumonia. Agreements between radiologists were assessed with kappa statistics. Diagnostic accuracy of chest CT compared with RT-PCR assay and patient outcomes was measured using receiver operating characteristics (ROC). Positive predictive value (PPV) and negative predictive value (NPV) for COVID-19 pneumonia were calculated. RESULTS: Inter-observer agreement for highly probable (kappa: 0.83 [p �?001]) and highly probable or probable (kappa: 0.82 [p �?001]) diagnosis of COVID-19 pneumonia was very good. RT-PCR tests performed in 307 patients were positive in 174 and negative in 133. The areas under the curve (AUC) were 0.94 and 0.92 respectively. With a disease prevalence of 61.2%, PPV were 95.9% and 94.3%, and NPV 84.4% and 77.1%. CONCLUSION: During acute COVID-19 outbreak, chest CT scan may be used for triage of patients with intermediate clinical probability with very good inter-observer agreements and diagnostic accuracy. KEY POINTS: �?Concordances between two chest radiologists to diagnose or exclude a COVID-19 pneumonia in 319 consecutive patients with intermediate clinical probability were very good (kappa: 0.82; p �?001). �?When compared with RT-PCR results and patient outcomes, the diagnostic accuracy of CT to identify COVID-19 pneumonia was high for both radiologists (AUC: 0.94 and 0.92). �?With a disease prevalence of 61.2% in the studied population, the positive predictive values of CT for diagnosing COVID-19 pneumonia were 95.9% and 94.3% with negative predictive values of 84.4% and 77.1%.
AD  - Department of Radiology, Hôpital Foch, 40 rue Worth, 92150, Suresnes, France. annelaure.brun@gmail.com.
Department of Radiology, Hôpital Foch, 40 rue Worth, 92150, Suresnes, France.
Department of Clinical Research and Innovation, Hôpital Foch, 40 rue Worth, 92150, Suresnes, France.
Department of Emergency Medicine, Hôpital Foch, 40 rue Worth, 92150, Suresnes, France.
Department of Clinical Biology, Hôpital Foch, 40 rue Worth, 92150, Suresnes, France.
INSERM, UMRS 1176, Paris-Saclay University, Le Kremlin-Bic�^tre, France.
AN  - 33011877
AU  - Brun, A. L.
AU  - Gence-Breney, A.
AU  - Trichereau, J.
AU  - Ballester, M. C.
AU  - Vasse, M.
AU  - Chabi, M. L.
AU  - Mellot, F.
AU  - Grenier, P. A.
C1  - 10/6/2020
C2  - PMC7532930
DA  - Oct 3
DB  - PubMed
DO  - 10.1007/s00330-020-07346-y
DP  - NLM
ET  - 2020/10/05
J2  - European radiology
KW  - Covid-19
Disease outbreak
Observer variation
ROC curve
Triage
products or services may be related to the subject matter of the article.
LA  - eng
N1  - 1432-1084
Brun, Anne Laure
Orcid: 0000-0002-4447-7850
Gence-Breney, Alexia
Trichereau, Julie
Ballester, Marie Christine
Vasse, Marc
Chabi, Marie Laure
Mellot, François
Grenier, Philippe A
Journal Article
Eur Radiol. 2020 Oct 3:1-9. doi: 10.1007/s00330-020-07346-y.
PY  - 2020
SN  - 0938-7994 (Print)
0938-7994
SP  - 1-9
ST  - COVID-19 pneumonia: high diagnostic accuracy of chest CT in patients with intermediate clinical probability
T2  - European radiology
TI  - COVID-19 pneumonia: high diagnostic accuracy of chest CT in patients with intermediate clinical probability
ID  - 7785648
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19) pandemic has resulted in significant challenges for nurses, both professionally and personally. In these unprecedented times, new opportunities to reflect on practice have emerged. Through reflection, whether individually or with others, nurses can explore areas of their practice that could be developed and improved. This article outlines the types of reflection and discusses its benefits and challenges, explaining how it is linked to nurses' regulatory revalidation processes. It also details various models and activities that nurses can use to reflect on their practice during the COVID-19 pandemic and beyond.
AD  - School of Nursing, Midwifery and Social Work, Canterbury Christ Church University, Kent, England.
AN  - 33016663
AU  - Brindley, J.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.7748/ns.2020.e11569
DP  - NLM
ET  - 2020/10/06
J2  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
KW  - Covid-19
continuing professional development
coronavirus
education
nurses�?wellbeing
personal development
practice learning
professional
professional issues
reflection
LA  - eng
N1  - 2047-9018
Brindley, Jane
Journal Article
Published Erratum
England
Nurs Stand. 2020 Oct 5. doi: 10.7748/ns.2020.e11569.
PY  - 2020
SN  - 0029-6570
ST  - Reflecting on nursing practice during the COVID-19 pandemic
T2  - Nursing standard (Royal College of Nursing (Great Britain) : 1987)
TI  - Reflecting on nursing practice during the COVID-19 pandemic
ID  - 7785189
ER  - 

TY  - JOUR
AB  - In response to the SARS-CoV-2 outbreak, and the resulting COVID-19 pandemic, a global competition to develop an anti-COVID-19 vaccine has ensued. The targeted time frame for initial vaccine deployment is late 2020. The present article examines whether short-term, mid-term, and long-term vaccine safety can be achieved under such an accelerated schedule, given the myriad vaccine-induced mechanisms that have demonstrated adverse effects based on previous clinical trials and laboratory research. It presents scientific evidence of potential pitfalls associated with eliminating critical phase II and III clinical trials, and concludes that there is no substitute currently available for long-term human clinical trials to ensure long-term human safety.
AN  - 2448244915
AU  - Briggs, Michael B.
AU  - Porter, Alan L.
AU  - Spandidos, Demetrios A.
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.3892/ijmm.2020.4733
DP  - ProQuest Central
IS  - 5
KW  - Medical Sciences
SARS-CoV-2
COVID-19 vaccine
COVID-19 pandemic
Clinical trials
Vaccines
Fertility
Costs
Severe acute respiratory syndrome coronavirus 2
Coronaviruses
Experiments
Decision making
Laboratory animals
COVID-19
Disease transmission
Alzheimers disease
LA  - English
N1  - Copyright - Copyright Spandidos Publications UK Ltd. 2020
PY  - 2020
SN  - 11073756
SP  - 1599
ST  - COVID-19 vaccine safety
T2  - International Journal of Molecular Medicine
TI  - COVID-19 vaccine safety
UR  - https://www.proquest.com/docview/2448244915?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=COVID-19+vaccine+safety&title=International+Journal+of+Molecular+Medicine&issn=11073756&date=2020-01-01&volume=46&issue=5&spage=1599&au=Briggs%2C+Michael+B.%3BPorter%2C+Alan+L.%3BSpandidos%2C+Demetrios+A.&isbn=&jtitle=International+Journal+of+Molecular+Medicine&btitle=&rft_id=info:eric/&rft_id=info:doi/10.3892%2Fijmm.2020.4733
VL  - 46
ID  - 7784947
ER  - 

TY  - JOUR
AB  - Tropical deforestation drivers are complex and can change rapidly in periods of profound societal transformation, such as those during a pandemic. Evidence suggests that the COVID-19 pandemic has spurred illegal, opportunistic forest clearing in tropical countries, threatening forest ecosystems and their resident human communities. A total of 9,583 km(2) of deforestation alerts from Global Land Analysis & Discovery (GLAD) were detected across the global tropics during the first month following the implementation of confinement measures of local governments to reduce COVID-19 spread, which is nearly double that of 2019 (4,732 km(2)). We present a conceptual framework linking tropical deforestation and the current pandemic. Zoonotic diseases, public health, economy, agriculture, and forests may all be reciprocally linked in complex positive and negative feedback loops with overarching consequences. We highlight the emerging threats to nature and society resulting from this complex reciprocal interplay and possible policy interventions that could minimize these threats.
AD  - Department of Forest Sciences, "Luiz de Queiroz" College of Agriculture, University of São Paulo, Piracicaba, SP 13418-900, Brazil.
Spatial Ecology and Conservation Lab, School of Forest Resources and Conservation, University of Florida, Gainesville, FL 32611, USA.
Department of Crop and Forest Sciences, University of Lleida, E-25198 Lleida, Spain.
Joint Research Unit CTFC - AGROTECNIO, E-25280, Solsona, Spain.
Technosylva Inc., La Jolla, CA, USA.
Department of Geography, University of São Paulo, São Paulo, SP 05508-000, Brazil.
Forest Advanced Computing and Artificial Intelligence Laboratory, Department of Forestry and Natural Resources, Purdue University, West Lafayette, IN 47907, USA.
International Consultant on Forestry Statistics, Rome, Italy.
International Institute for Sustainability, Rio de Janeiro, RJ 22460-320, Brazil.
International Institute for Sustainability Australia, ACT 2602, Australia.
Mestrado Profissional em Ci�^ncias do Meio Ambiente, Universidade Veiga de Almeida, Rio de Janeiro, RJ 20271-901, Brazil.
Cirad, UPR For�^ts and Societies, Yamoussoukro, Ivory Coast.
Forests and Societies, Univiversity of Montpellier, Cirad, Montpellier, France.
Institut National Polytechnique Félix Houphouët-Boigny, INPHB, Yamoussoukro, Ivory Coast.
Remote Sensing Division, National Institute for Space Research (INPE), Av. dos Astronautas, 1758, 12227-010, São José dos Campos, São Paulo, Brazil.
College of Life and Environmental Sciences, University of Exeter, Exeter EX4 4RJ, United Kingdom.
Department of Geographical Sciences, University of Maryland, College Park, Maryland, MD 20740, USA.
School of Forest Resources and Conservation, University of Florida, Gainesville, FL 32611, USA.
Spatial Ecology and Conservation Lab, Center for Latin American Studies, University of Florida, Gainesville, FL 32611, USA.
AN  - 33020748
AU  - Brancalion, P. H. S.
AU  - Broadbent, E. N.
AU  - de-Miguel, S.
AU  - Cardil, A.
AU  - Rosa, M. R.
AU  - Almeida, C. T.
AU  - Almeida, D. R. A.
AU  - Chakravarty, S.
AU  - Zhou, M.
AU  - Gamarra, J. G. P.
AU  - Liang, J.
AU  - Crouzeilles, R.
AU  - Hérault, B.
AU  - Aragão, Leoc
AU  - Silva, C. A.
AU  - Almeyda-Zambrano, A. M.
C1  - 10/6/2020
C2  - PMC7526655
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.pecon.2020.09.006
DP  - NLM
ET  - 2020/10/07
J2  - Perspectives in ecology and conservation
LA  - eng
N1  - 2530-0644
Brancalion, Pedro H S
Broadbent, Eben N
de-Miguel, Sergio
Cardil, Adri֙n
Rosa, Marcos R
Almeida, Catherine T
Almeida, Danilo R A
Chakravarty, Shourish
Zhou, Mo
Gamarra, Javier G P
Liang, Jingjing
Crouzeilles, Renato
Hérault, Bruno
Aragão, Luiz E O C
Silva, Carlos Alberto
Almeyda-Zambrano, Angelica M
Journal Article
Brazil
Perspect Ecol Conserv. 2020 Sep 30. doi: 10.1016/j.pecon.2020.09.006.
PY  - 2020
SN  - 2530-0644
ST  - Emerging threats linking tropical deforestation and the COVID-19 pandemic
T2  - Perspectives in ecology and conservation
TI  - Emerging threats linking tropical deforestation and the COVID-19 pandemic
ID  - 7784981
ER  - 

TY  - JOUR
AB  - Research question: The COVID-19 pandemic decimated elite level sport across the globe, although there were concerns that this impact affected women’s sport much more so than for men’s sport. This research considers the impact of the enforced global lockdown on elite women athletes, examining the immediate effect on their training practices, welfare and financial situation. Methods: A qualitative, online survey was used to collect anonymous data from 95 elite sportswomen. Data were coded to enable frequency analysis, and then analysed thematically. Results: Many sportswomen noted the positive support received from coaching networks regarding adapted, individualised training programmes and their mental well-being. A reduction in time spent training, and changes to types of training, was reported. However, many felt they had less access to equipment as women, and that men’s sport was a priority. Professional and semi-professional sportswomen, already operating in financially precarious circumstances, were also impacted through a reduction in match fees and/or sponsorship, or furlough. Implications: The findings provide empirical evidence of a gendered dimension to the experiences of elite athletes during lockdown. When elite sport re-builds post-COVID, there should be a greater awareness of the difficulties faced by sportswomen, and targeted action to tackle gender inequality in sport. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
AD  - Department of Sport Science, Nottingham Trent University, Nottingham, United Kingdom
Independent Researcher, United Kingdom
AU  - Bowes, A.
AU  - Lomax, L.
AU  - Piasecki, J.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1080/23750472.2020.1825988
J2  - Manag. Sport Leis.
KW  - COVID-19
lockdown
professional sport
well-being
Women’s sport
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Bowes, A.; Department of Sport Science, Nottingham Trent UniversityUnited Kingdom; email: ali.bowes@ntu.ac.uk
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Sustainability (2020) Practice and Policy, 16 (1), pp. 67-73. , https://doi.org/10.1080/15487733.2020.1776561; Rowan, K., (2019) Exclusive: English women’s club rugby players to be paid for the first time, , https://www.telegraph.co.uk/rugby-union/2019/09/03/exclusive-english-womens-club-rugby-players-paid-first-time/; Rowe, D., Subjecting pandemic sport to a sociological procedure (2020) Journal of Sociology, pp. 1-9. , https://doi.org/10.1177/1440783320941284; Schinke, R., Papaioannou, A., Henriksen, K., Si, G., Zhang, L., Haberl, P., Sport psychology services to high performance athletes during COVID-19 (2020) International Journal of Sport and Exercise Psychology, 18 (3), pp. 269-272. , https://doi.org/10.1080/1612197X.2020.1754616; (2020) ECB’s Clare Connor says England’s men’s cricket could take priority over women’s game this summer | Cricket News | Sky Sports, , https://www.skysports.com/cricket/news/12173/11984290/ecbs-clare-connor-says-englands-mens-cricket-could-take-priority-over-womens-game-this-summer; Taylor, T., O’Connor, D., Hanlon, C., Contestation, disruption and legitimization in women’s rugby league (2019) Sport in Society, 23 (2), pp. 315-334. , https://doi.org/10.1080/17430437.2019.1631803; Tomas, F., (2020) Manchester Thunder frustrated by England Netball cancelling Superleague, , https://www.telegraph.co.uk/netball/2020/05/27/england-netball-ends-2020-superleague-season-due-coronavirus/; Tomas, F., Whyatt, K., McElwee, M., (2020) Special report: As men’s sport clamours to restart, how women’s sport is being abandoned, , https://www.telegraph.co.uk/womens-sport/2020/05/29/special-report-will-see-game-womens-team-sport-will-damage/, The Telegraph; (2020) COVID-19, Women, Girls and Sport: Build Back Better, , https://www.unwomen.org/-/media/headquarters/attachments/sections/library/publications/2020/brief-covid-19-women-girls-and-sport-en.pdf?la=en%26vs=2629; van Dalen, H.P., Henkens, K., The COVID-19 pandemic: Lessons for financially fragile and aging societies (2020) Work, Aging and Retirement, pp. 1-4. , https://doi.org/10.1093/workar/waaa011; Weiller, K.H., Higgs, C.T., The All American girls professional Baseball League, 1943�?954: Gender Conflict in sport? 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PY  - 2020
SN  - 23750472 (ISSN)
ST  - The impact of the COVID-19 lockdown on elite sportswomen
T2  - Managing Sport and Leisure
TI  - The impact of the COVID-19 lockdown on elite sportswomen
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091733411&doi=10.1080%2f23750472.2020.1825988&partnerID=40&md5=578168d98bfe19821a139c2aa8c85f5c
ID  - 7783314
ER  - 

TY  - JOUR
AB  - The aim of this study was to explore the role of lung ultrasound (LUS) in the diagnosis of SARS-CoV-2 infection and to verify its utility in the prediction of lung disease's severity and outcome. Fifty-three consecutive patients presenting to the Emergency Department of Santa Maria delle Grazie Hospital with high suspicion of SARS-CoV-2 infection underwent diagnostic test for SARS-CoV-2 on samples obtained from nasopharyngeal swab as well as complete proper diagnostic work-up that included clinical evaluation, laboratory tests, blood gas analyses, chest CT and LUS. A semiquantitative analysis of B-lines distribution was performed to calculate the LUS score. Patients were divided into two groups according to the results of both SARS-CoV-2 diagnostic test and other exams (Group A�? pneumonia due to SARS-CoV2 infection vs Group B�? no SARS-CoV2 infection and another definite diagnosis). LUS showed an excellent accuracy in predicting the diagnosis of SARS-CoV-2 infection (area under the ROC curve of 0.92 with a sensibility of 73% and a specificity of 89% a the cut-off of 12.5). LUS score was more impaired in SARS-CoV-2 patients (18.1 ±�?.0 vs 7.6 ±�?.9, p �?.00001) and it is significantly negatively correlated with PF ratio values (r�?�?�?.719, p �?.0001). An intrahospital mortality rate of 46% was found; patients with adverse outcome had significant higher value of LUS, PF, LDH, and APACHE II score. None of these parameters was predictive of mortality. LUS is a useful tool for the early detection of SARS-CoV-2 infection and for the evaluation of the disease severity, but does not predict mortality. Further studies with repeated evaluations of LUS score are needed to further explore the role of LUS in the assessment of severity in SARS-CoV-2 disease and in the monitoring of the response to treatments.
AD  - Department of Emergency Medicine, COVID Care Unit, Santa Maria Delle Grazie Hospital, Via Domitiana, 5, 80078, Pozzuoli, Naples, Italy. giorgio.bosso@aslnapoli2nord.it.
Department of Emergency Medicine, COVID Care Unit, Santa Maria Delle Grazie Hospital, Via Domitiana, 5, 80078, Pozzuoli, Naples, Italy.
Department of Translational Medical Sciences, Federico II University, Naples, Italy.
AN  - 33011929
AU  - Bosso, G.
AU  - Allegorico, E.
AU  - Pagano, A.
AU  - Porta, G.
AU  - Serra, C.
AU  - Minerva, V.
AU  - Mercurio, V.
AU  - Russo, T.
AU  - Altruda, C.
AU  - Arbo, P.
AU  - De Sio, C.
AU  - Dello Vicario, F.
AU  - Numis, F. G.
C1  - 10/6/2020
C2  - PMC7532928
DA  - Oct 3
DB  - PubMed
DO  - 10.1007/s11739-020-02512-y
DP  - NLM
ET  - 2020/10/05
J2  - Internal and emergency medicine
KW  - LUS score
Lung ultrasound
P/F ratio
SARS-CoV-2
LA  - eng
N1  - 1970-9366
Bosso, Giorgio
Orcid: 0000-0002-2759-8343
Allegorico, Enrico
Pagano, Antonio
Porta, Giovanni
Serra, Claudia
Minerva, Valentina
Mercurio, Valentina
Russo, Teresa
Altruda, Concetta
Arbo, Paola
De Sio, Chiara
Dello Vicario, Ferdinando
Numis, Fabio Giuliano
Journal Article
Intern Emerg Med. 2020 Oct 3:1-6. doi: 10.1007/s11739-020-02512-y.
PY  - 2020
SN  - 1828-0447 (Print)
1828-0447
SP  - 1-6
ST  - Lung ultrasound as diagnostic tool for SARS-CoV-2 infection
T2  - Internal and emergency medicine
TI  - Lung ultrasound as diagnostic tool for SARS-CoV-2 infection
ID  - 7785643
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) is a respiratory tract infection caused by a newly emergent coronavirus, SARS-CoV-2. The acute phase may be followed by a second phase actually not yet completely understood but probably associated to an autoimmune activation. At the moment is not possible to clearly define an association between immunological findings and pathological symptoms, however, this case report describes the case of a patient who following COVID-19 infection development autoimmune antibodies who persist in time longer than viral phase. Those antibodies can be responsible for the multi pathological clinical picture showed from our patient that, according to EULAR 2019 criteria, could be classified as systemic lupus erythematosus (SLE). SLE is probably one of the possible chronic rheumatologic diseases triggers by COVID-19 and this is the first case of SLE with vasculitis actually described in literature.
AD  - Department of Emergency Medicine, Santi Antonio e Biagio e Cesare Arrigo Hospital, Alessandria, Italy. ramona.bonometti@gmail.com.
AN  - 33015814
AU  - Bonometti, R.
AU  - Sacchi, M. C.
AU  - Stobbione, P.
AU  - Lauritano, E. C.
AU  - Tamiazzo, S.
AU  - Marchegiani, A.
AU  - Novara, E.
AU  - Molinaro, E.
AU  - Benedetti, I.
AU  - Massone, L.
AU  - Bellora, A.
AU  - Boverio, R.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23060
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Bonometti, R
Sacchi, M C
Stobbione, P
Lauritano, E C
Tamiazzo, S
Marchegiani, A
Novara, E
Molinaro, E
Benedetti, I
Massone, L
Bellora, A
Boverio, R
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9695-9697. doi: 10.26355/eurrev_202009_23060.
PY  - 2020
SN  - 1128-3602
SP  - 9695-9697
ST  - The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection
T2  - European review for medical and pharmacological sciences
TI  - The first case of systemic lupus erythematosus (SLE) triggered by COVID-19 infection
VL  - 24
ID  - 7785250
ER  - 

TY  - JOUR
AU  - Bong, Choon-Looi
AU  - Brasher, Christopher
AU  - Chikumba, Edson
AU  - McDougall, Robert
AU  - Mellin-Olsen, Jannicke
C1  - 10/6/2020
DA  - 2020/06
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - en
PY  - 2020
ST  - Response to Letter by Dr Subendi
TI  - Response to Letter by Dr Subendi
UR  - https://dx.doi.org/10.1213/ANE.0000000000005061
ID  - 7788721
ER  - 

TY  - JOUR
AD  - Adult Reconstruction and Joint Replacement Service, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021 USA. GRID: grid.239915.5. ISNI: 0000 0001 2285 8823
AN  - 33013245
AU  - Boettner, F.
AU  - Bostrom, M. P.
AU  - Figgie, M.
AU  - Gonzalez Della Valle, A.
AU  - Haas, S.
AU  - Mayman, D.
AU  - Padgett, D.
C1  - 10/6/2020
C2  - PMC7524030
DA  - Sep 29
DB  - PubMed
DO  - 10.1007/s11420-020-09801-4
DP  - NLM
ET  - 2020/10/06
J2  - HSS journal : the musculoskeletal journal of Hospital for Special Surgery
KW  - Covid-19
arthroplasty
elective surgery
interest. Friedrich Boettner, MD, reports grants and personal fees from Smith &
Nephew and personal fees from OrthoDevelopment, Depuy, and Medtronic, outside the
submitted work. Mathias Bostrom, MD, reports grants and personal fees from Smith &
Nephew, grants from Ines Mandl Research Foundation, outside the submitted work. Mark
Figgie, MD, reports board membership, consulting fees, royalties, and stock
ownership from Wishbone, stock ownership from Insight, HS2, and Mekanika, and
royalties and consulting fees from Lima, outside the submitted work. Steven Haas,
MD, reports grants, personal fees, and royalties from Smith & Nephew, personal fees
from OrthAlign and Heraeus, and ownership interest in OpLogix, outside the submitted
work. David Mayman, MD, reports personal fees and royalties from Smith & Nephew,
royalties and stock options from Orthoalign, and investment in Wishbone, InSight,
and Cymedica, outside the submitted work. Douglas Padgett, MD, reports personal fees
from DJO global and stock or stock options from PSI LLC, Tangen, and Orthophor,
outside the submitted work.
LA  - eng
N1  - 1556-3324
Boettner, Friedrich
Bostrom, Mathias P
Figgie, Mark
Gonzalez Della Valle, Alejandro
Haas, Steven
Mayman, David
Padgett, Douglas
Journal Article
HSS J. 2020 Sep 29:1-7. doi: 10.1007/s11420-020-09801-4.
PY  - 2020
SN  - 1556-3316 (Print)
1556-3316
SP  - 1-7
ST  - Timeline and Procedures on Restarting Non-Emergent Arthroplasty Care in the US Epicenter of the COVID-19 Pandemic
T2  - HSS journal : musculoskeletal journal of Hospital for Special Surgery
TI  - Timeline and Procedures on Restarting Non-Emergent Arthroplasty Care in the US Epicenter of the COVID-19 Pandemic
ID  - 7785472
ER  - 

TY  - JOUR
AB  - Vitamin D (VitD) deficiency is considered a global problem and might be associated with higher risk to get COVID-19 illness. In the light of COVID-19 pandemic, VitD might be a promising agent for fighting the SARS-CoV-2, since VitD is involved in various pathophysiological mechanisms that occur during COVID-19 infection. High-dose VitD supplementation, particularly for risk groups, could be recommended to achieve and maintain optimal (range 40-60 ng/ml) serum 25-hydroxy vitamin D levels (marker of VitD status) both for COVID-19 prevention and treatment.
AD  - Vilnius University, Faculty of Medicine, Clinic of Internal Diseases, Family Medicine and Oncology, Santari�Qkių 2, LT- 08661, Vilnius, Lithuania.
AN  - 33012103
AU  - Bleizgys, A.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/ijcp.13748
DP  - NLM
ET  - 2020/10/05
J2  - International journal of clinical practice
KW  - 25-hydroxy vitamin D
Covid-19
SARS-CoV-2
calcitriol
supplementation
vitamin D
LA  - eng
N1  - 1742-1241
Bleizgys, Andrius
Orcid: 0000-0002-0285-6123
Journal Article
Review
England
Int J Clin Pract. 2020 Oct 4:e13748. doi: 10.1111/ijcp.13748.
PY  - 2020
SN  - 1368-5031
SP  - e13748
ST  - Vitamin D AND COVID-19: It is time to act
T2  - International journal of clinical practice
TI  - Vitamin D AND COVID-19: It is time to act
ID  - 7785621
ER  - 

TY  - JOUR
AB  - With an increasing number of SARS-CoV-2 sequences available day by day, new genomic information is getting revealed to us. As SARS-CoV-2 sequences highlight wide changes across the samples, we aim to explore whether these changes reveal the geographical origin of the corresponding samples. The k-mer distributions, denoting normalized frequency counts of all possible combinations of nucleotide of size upto k, are often helpful to explore sequence level patterns. Given the SARS-CoV-2 sequences are highly imbalanced by its geographical origin (relatively with a higher number samples collected from the USA), we observe that with proper under-sampling k-mer distributions in the SARS-CoV-2 sequences predict its geographical origin with more than 90% accuracy. The experiments are performed on the samples collected from six countries with maximum number of sequences available till July 07, 2020. This comprises SARS-CoV-2 sequences from Australia, USA, China, India, Greece and France. Moreover, we demonstrate that the changes of genomic sequences characterize the continents as a whole. We also highlight that the network motifs present in the sequence similarity networks have a significant difference across the said countries. This, as a whole, is capable of predicting the geographical shift of SARS-CoV-2.Competing Interest StatementThe authors have declared no competing interest.
AU  - Biswas, Sourav
AU  - Saha, Suparna
AU  - Bandyopadhyay, Sanghamitra
AU  - Bhattacharyya, Malay
C1  - 10/6/2020
DB  - bioRxiv
DO  - 10.1101/2020.10.04.325662
DP  - bioRxiv
PY  - 2020
SP  - 2020.10.04.325662
ST  - Motif Analysis in k-mer Networks: An Approach towards Understanding SARS-CoV-2 Geographical Shifts (preprint)
T2  - bioRxiv
TI  - Motif Analysis in k-mer Networks: An Approach towards Understanding SARS-CoV-2 Geographical Shifts (preprint)
UR  - http://biorxiv.org/content/early/2020/10/05/2020.10.04.325662.abstract
ID  - 7788865
ER  - 

TY  - JOUR
AB  - BACKGROUND: Lombardy, in the northern Italy, was one of the most affected region in the world by novel coronavirus COVID-19 outbreak. Due to the dramatic amount of confirmed positive cases and deaths, all clinical and surgical hospital departments changed their daily activities to face emergent pandemic situations. In particular, vascular surgery units reorganized their role and priorities for both elective and urgent patients requiring open or endovascular interventions. MATERIAL & METHODS: This brief review summarizes organization of vascular Lombardy centers network adopted during pandemic period and clinical evidences published so far by regional referral and nonreferral hospitals in terms of vascular surgery and medicine implications in COVID-19 positive or negative patients managements. RESULTS: Different patterns of disease were described during phase 1 COVID-19 outbreak in Lombardy region, with major attention in pheriperal artery disease and venous thrombosis. CONCLUSION: COVID-19 infection seems to be not only a pulmonary but also a vascular (arterial and venous) disease. Further study are necessary to described mid and long-term outcomes in COVID-19 vascular patients population.
AD  - Vascular Surgery Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical and Community Sciences, University of Milan, Milan, Italy.
Division of Vascular Surgery, Department of Cardiovascular Surgery, Fondazione Poliambulanza, Brescia, Italy.
Department of Medicine and Surgery, University of Insubria School of Medicine and ASST Settelaghi, Varese, Italy.
AN  - 33012015
AU  - Bissacco, D.
AU  - Grassi, V.
AU  - Lomazzi, C.
AU  - Domanin, M.
AU  - Bellosta, R.
AU  - Piffaretti, G.
AU  - Trimarchi, S.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/jocs.15069
DP  - NLM
ET  - 2020/10/05
J2  - Journal of cardiac surgery
KW  - Covid-19
acute limb ischemia
aorta and great vessels
vascular emergencies
vascular surgery
LA  - eng
N1  - 1540-8191
Bissacco, Daniele
Orcid: 0000-0003-0724-0237
Grassi, Viviana
Lomazzi, Chiara
Domanin, Maurizio
Bellosta, Raffaello
Piffaretti, Gabriele
Orcid: 0000-0002-9906-4658
Trimarchi, Santi
Journal Article
Review
United States
J Card Surg. 2020 Oct 4. doi: 10.1111/jocs.15069.
PY  - 2020
SN  - 0886-0440
ST  - Is there a vascular side of the story? Vascular consequences during COVID-19 outbreak in Lombardy, Italy
T2  - Journal of cardiac surgery
TI  - Is there a vascular side of the story? Vascular consequences during COVID-19 outbreak in Lombardy, Italy
ID  - 7785630
ER  - 

TY  - GEN
AN  - NCT04576728
AU  - Biotest
C1  - 10/6/2020
DA  - October
DB  - ClinicalTrials
DP  - ClinicalTrials
KW  - Covid19
N1  - No Results Available
Drug: Trimodulin|Other: Placebo (human albumin 1%)
Clinical detoriation rate|28-day all-cause mortality rate|Clinical deterioration rate|28-days all-cause mortality rate on day 29|Time to clinical deterioration|Time to Mortality|Proportion of subjects in each of the 9-categories of the ordinal scale|Time to clinical improvement|Proportion of subjects with score �?|Days on IMV|Days without oxygen supply|Time to discontinuation from any form of oxygen supply|Proportion of subjects without any form of oxygen supply|Hospital-free-days|SARS-CoV-2 status|Adverse events (AEs), treatment-emergent AEs (TEAEs), AEs of special interest, infusional TEAEs|TEAEs|SAEs|Dose modifications|Time to recovery|Change over time in ECG parameters|Change over time in vital signs
All
Phase 2
164
Industry
Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Treatment
998
March 2021
PB  - https://ClinicalTrials.gov/show/NCT04576728
PY  - 2020
ST  - ESsCOVID
T2  - ClinicalTrials
TI  - Efficacy and Safety of Trimodulin in Subjects With Severe COVID-19
UR  - https://ClinicalTrials.gov/show/NCT04576728
ID  - 7788851
ER  - 

TY  - JOUR
AU  - Bharati, Kaushik
AU  - Garg, Aarti
AU  - Das, Sunanda
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Challenges in Delivering Optimal Healthcare to COVID-19 Patients: Focus on Delhi, India
T2  - Journal of Clinical and Diagnostic Research
TI  - Challenges in Delivering Optimal Healthcare to COVID-19 Patients: Focus on Delhi, India
UR  - https://doi.org/10.7860/jcdr/2020/5365.14061
ID  - 7788412
ER  - 

TY  - JOUR
AB  - BACKGROUND: The COVID-19 pandemic in Italy represents a unique threat in terms of psychological distress. This cross-sectional study aims to investigate the psychological health of Italian healthcare professionals during the COVID-19 outbreak. We assessed participants' current psychological distress and coping strategies in the midst of the COVID outbreak (March-April 2020), and also asked them to retrospectively report how they remember feeling before the COVID-19 outbreak (December 2019). We examined associations between psychological distress and coping strategies with mental health and infection perceptions. METHODS: Self-administered questionnaires were distributed online to healthcare professionals (N = 580) residing in different Italian regions from 26 March to 9 April 2020. The questionnaire measured changes in psychological states, coping strategies, and demographic variables testing variations in mental health and infection risk perception among Italian healthcare workers. RESULTS: Overall, approximately 33.5 per cent of healthcare professionals in our sample meet the threshold for psychiatric morbidity. Participants perceive their current psychological health to be worse during the COVID-19 emergency outbreak as compared to before the outbreak, and this was especially true among women. CONCLUSIONS: Both immediate and long-term monitoring psychological assistance services for healthcare workers should be implemented by national institutions to re-establish the psychological well-being and enhance the self-confidence and resilience of hospital personnel.
AD  - New York University Abu Dhabi, United Arab Emirates.
Università degli Studi di Padova, Italy.
Azienda Ospedaliero Universitaria Consorziale Policlinico di Bari, Italy.
Istituto Clinico Sant'Anna Brescia, Italy.
AN  - 33016564
AU  - Bettinsoli, M. L.
AU  - Di Riso, D.
AU  - Napier, J. L.
AU  - Moretti, L.
AU  - Bettinsoli, P.
AU  - Delmedico, M.
AU  - Piazzolla, A.
AU  - Moretti, B.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/aphw.12239
DP  - NLM
ET  - 2020/10/06
J2  - Applied psychology. Health and well-being
KW  - Covid-19
Italy
healthcare workers
mental health
risk perception
LA  - eng
N1  - 1758-0854
Bettinsoli, Maria Laura
Orcid: 0000-0002-5860-2675
Di Riso, Daniela
Orcid: 0000-0002-3759-0441
Napier, Jaime L
Orcid: 0000-0002-5507-3798
Moretti, Lorenzo
Bettinsoli, Pierfrancesco
Delmedico, Michelangelo
Piazzolla, Andrea
Moretti, Biagio
Orcid: 0000-0002-1234-8616
Journal Article
England
Appl Psychol Health Well Being. 2020 Oct 5. doi: 10.1111/aphw.12239.
PY  - 2020
SN  - 1758-0854
ST  - Mental Health Conditions of Italian Healthcare Professionals during the COVID-19 Disease Outbreak
T2  - Applied psychology Health and well-being
TI  - Mental Health Conditions of Italian Healthcare Professionals during the COVID-19 Disease Outbreak
ID  - 7785194
ER  - 

TY  - JOUR
AB  - The impact of COVID-19 on the U.S. healthcare industry cannot be overstated. Telemedicine utilization increased overnight as all healthcare providers rushed to implement this delivery model to ensure accessibility and continuity of patient care. Our research objective was to determine measures that were implemented to accommodate community and individual patient needs to afford access to critical services and to maintain safety standards. We analyzed literature since 2016 from two databases using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We compared observations, themes, service lines addressed, issues identified, and interventions requiring in-person care. From 44 articles published, we identified ten effectiveness themes overall and drew conclusions on service line successes. COVID-19 has caused rapid expansion in telemedicine. Necessary and required changes in access, risk mitigation, the need for social distancing, compliance, cost, and patient satisfaction are a few of the driving factors. This review showcased the healthcare industry's ability to rapidly acclimate and change despite the pervasive spread of COVID-19 throughout the U.S. Although imperfect, unique responses were developed within telemedicine platforms to mitigate disruptions broadly and effectively in care and treatment modalities.
AD  - School of Health Administration, Texas State University, San Marcos, TX 78666, USA.
AN  - 33019667
AU  - Betancourt, J. A.
AU  - Rosenberg, M. A.
AU  - Zevallos, A.
AU  - Brown, J. R.
AU  - Mileski, M.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.3390/healthcare8040380
DP  - NLM
ET  - 2020/10/07
IS  - 4
J2  - Healthcare (Basel, Switzerland)
KW  - Covid-19
health service lines
pandemic
telehealth
telemedicine
LA  - eng
N1  - Betancourt, Jose A
Orcid: 0000-0003-0146-8476
Rosenberg, Matthew A
Orcid: 0000-0001-7107-4128
Zevallos, Ashley
Orcid: 0000-0001-8905-2824
Brown, Jon R
Orcid: 0000-0003-2236-7121
Mileski, Michael
Orcid: 0000-0003-1503-6869
Journal Article
Review
Switzerland
Healthcare (Basel). 2020 Oct 1;8(4):E380. doi: 10.3390/healthcare8040380.
PY  - 2020
SN  - 2227-9032 (Print)
2227-9032
ST  - The Impact of COVID-19 on Telemedicine Utilization Across Multiple Service Lines in the United States
T2  - Healthcare (Basel, Switzerland)
TI  - The Impact of COVID-19 on Telemedicine Utilization Across Multiple Service Lines in the United States
VL  - 8
ID  - 7785090
ER  - 

TY  - JOUR
AB  - Not applicable because this is an editorial.
AD  - Surrey Pathology Services, Clinical Biochemistry, Royal Surrey County Hospital, Guildford, United Kingdom of Great Britain and Northern Ireland.
Surrey Pathology Services, Bowel Cancer Screening Southern Hub, Royal Surrey County Hospital, 20 Priestley Road, Surrey Research Park, Guildford, United Kingdom of Great Britain and Northern Ireland.
Scottish Bowel Screening Centre Laboratory, Kings Cross, Dundee, United Kingdom of Great Britain and Northern Ireland.
AN  - 33016079
AU  - Benton, S. C.
AU  - Fraser, C. G.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/0004563220967569
DP  - NLM
ET  - 2020/10/06
J2  - Annals of clinical biochemistry
KW  - Cancer
Haemoglobin
Immunoassay
LA  - eng
N1  - 1758-1001
Benton, Sally C
Orcid: 0000-0001-9230-9088
Fraser, Callum George
Orcid: 0000-0002-1333-7994
Journal Article
England
Ann Clin Biochem. 2020 Oct 5:4563220967569. doi: 10.1177/0004563220967569.
PY  - 2020
SN  - 0004-5632
SP  - 4563220967569
ST  - EXPRESS: Faecal immunochemical tests in the COVID-19 pandemic; safety-netting of patients with symptoms and low faecal haemoglobin concentration â can a repeat test be used?
T2  - Annals of clinical biochemistry
TI  - EXPRESS: Faecal immunochemical tests in the COVID-19 pandemic; safety-netting of patients with symptoms and low faecal haemoglobin concentration â can a repeat test be used?
ID  - 7785227
ER  - 

TY  - JOUR
AU  - Belton, Keith
AU  - Mandel, Michael
AU  - Duesterberg, Thomas
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - supply chains, re-shoring, manufacturing, competitiveness, industrial policy
PY  - 2020
ST  - Policies to Enhance the Resilience of US Manufacturing (preprint)
T2  - SSRN
TI  - Policies to Enhance the Resilience of US Manufacturing (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693461
ID  - 7788906
ER  - 

TY  - JOUR
AD  - EUPHA Public Health Policy and Politics Section, EUPHA-PHMR, PO Box 1568, 3500 BN Utrecht, Netherlands.
Department of Global Public Health, Karolinska Institutet, Tomtebodavagen 18a, 17177, Stockholm, Sweden.
AN  - 33020828
AU  - Bekker, M.
AU  - Ivankovic, D.
AU  - Biermann, O.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1093/eurpub/ckaa181
DP  - NLM
ET  - 2020/10/07
IS  - 5
J2  - European journal of public health
LA  - eng
N1  - 1464-360x
Bekker, Marleen
Ivankovic, Damir
Biermann, Olivia
Journal Article
England
Eur J Public Health. 2020 Oct 1;30(5):854-855. doi: 10.1093/eurpub/ckaa181.
PY  - 2020
SN  - 1101-1262
SP  - 854-855
ST  - Early lessons from COVID-19 response and shifts in authority: public trust, policy legitimacy and political inclusion
T2  - European journal of public health
TI  - Early lessons from COVID-19 response and shifts in authority: public trust, policy legitimacy and political inclusion
VL  - 30
ID  - 7784972
ER  - 

TY  - JOUR
AB  - Purpose Right now, our world is in the grip of the COVID-19 pandemic. The global spread of COVID-19 (SARS-CoV-2) has dramatically increased the number of suspected cases with an expanding geographical area. The rapid identification of asymptomatic and mildly symptomatic contacts is the priority for clinical management and outbreak control. Suspected cases should be screened for the virus with a nucleic acid amplification test (NAAT) such as real-time reverse transcriptase-polymerase chain reaction (RT-PCR) under the guidance of laboratory experts. Materials and methods This manuscript details the process of the establishment of a COVID-19 lab, which is a medical college virology lab (Viral Research Diagnostic Lab), in less than a months' time. Detailed data of the tests were studied over the initial one month and reported. Results Within one and a half months of the start of the lab, 3196 tests were conducted, which caters to five adjoining districts in Western Odisha. These included both symptomatic and asymptomatic cases (contacts with a travel history from affected areas), and six COVID-19 positive cases were detected. Conclusion Though the establishment of a COVID-19 lab in a short time is a challenge, it can be achieved through determination, teamwork, and support from the authorities.
AD  - Microbiology, Veer Surendra Sai Institute of Medical Sciences and Research, Sambalpur, IND.
AN  - 33014657
AU  - Behera, S. K.
AU  - Mohapatra, S., Jr.
AU  - Pattnaik, D.
AU  - Jena, S.
AU  - Thakur, S.
AU  - Sahu, S.
C1  - 10/6/2020
C2  - PMC7526966
DA  - Aug 31
DB  - PubMed
DO  - 10.7759/cureus.10162
DP  - NLM
ET  - 2020/10/06
IS  - 8
J2  - Cureus
KW  - covid-19
pandemic
realtime reverse transcriptase - pcr
rt-pcr
sars-cov-2
LA  - eng
N1  - 2168-8184
Behera, Sulin K
Mohapatra, Soumyashree Jr
Pattnaik, Dipankar
Jena, Swetalina
Thakur, Satyabrata
Sahu, Sumanta
Journal Article
Cureus. 2020 Aug 31;12(8):e10162. doi: 10.7759/cureus.10162.
PY  - 2020
SN  - 2168-8184 (Print)
2168-8184
SP  - e10162
ST  - COVID-19 Lab: A Whistlestop Journey at a Tertiary Health Care Center
T2  - Cureus
TI  - COVID-19 Lab: A Whistlestop Journey at a Tertiary Health Care Center
VL  - 12
ID  - 7785377
ER  - 

TY  - JOUR
AB  - With the advent of rapid international travel, disease can now spread between nations faster than ever. As such, when outbreaks occur in foreign states, pressure mounts to reduce the risk of importing cases to the home nation. In a previous paper, we developed a model to investigate the potential effectiveness of deploying screening at airports during outbreaks of influenza, SARS, and Ebola. We also applied the model to the current COVID-19 outbreak. This model simulated the testing of travellers (assumed not to be displaying symptoms prior to boarding their flight) as they arrived at their destination. The model showed that the reduction in risk of case importation that screening alone could deliver was minimal across most scenarios considered, with outputs indicating that screening alone could detect at most 46.4%, 12.9%, and 4.0% of travellers infected with influenza, SARS and Ebola respectively, while the model also reported a detection rate of 12.0% for COVID-19. In this paper, we present a brief modification to this model allowing us to assess the added impact that quarantining incoming travelers for various periods may have on reducing the risk of case importation. Primary results show that requiring all travellers to undergo 5 days of self-isolation on arrival, after which they are tested again, has the potential to increase rates of detection to 100%, 87.6%, 81.7% and 41.3% for travellers infected with influenza, SARS, COVID-19 and Ebola respectively. Extending the period of self-isolation to 14 days increases these potential detection rates to 100%, 100%, 99.5% and 91.8% respectively.Competing Interest StatementThe authors have declared no competing interest.Funding StatementNo funding to declareAuthor DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:N/AAll necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesSupplementary material is included at the end of the paper
AU  - Bays, Declan
AU  - Bennett, Emma
AU  - Finnie, Thomas
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20205757
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20205757
ST  - Investigating the potential benefit that requiring travellers to self-isolate on arrival may have upon the reducing of case importations during international outbreaks of influenza, SARS, Ebola virus disease and COVID-19 (preprint)
T2  - medRxiv
TI  - Investigating the potential benefit that requiring travellers to self-isolate on arrival may have upon the reducing of case importations during international outbreaks of influenza, SARS, Ebola virus disease and COVID-19 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20205757.abstract
ID  - 7788874
ER  - 

TY  - JOUR
AU  - Bassuni, Majid
AU  - Helmy, Ahmed-Hazem I.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - "Primum non nocere" - first do no harm - in the time of SARS-CoV-2/COVID-19 Pandemic
T2  - Egyptian Journal of Surgery
TI  - "Primum non nocere" - first do no harm - in the time of SARS-CoV-2/COVID-19 Pandemic
UR  - https://doi.org/10.4103/ejs.ejs_145_20
ID  - 7788392
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To investigate patient characteristics and factors that increase the risk of being admitted to intensive care and that influence survival in cases of SARS-CoV-2 pneumonia. PATIENTS AND METHODS: One-hundred and ninety-one SARS-CoV-2 patients were admitted to the "Fondazione Poliambulanza di Brescia" Hospital (Brescia, Lombardy, Italy) in the period 1st March 2020 to 11th April 2020. Data on demographics, clinical presentation at admission, co-morbidities, pharmacological treatment, admission to intensive care and death was recorded. Logistic regression and survival analysis were carried out to investigate the risk of being admitted to intensive care and the risk of death. RESULTS: The mean age of the study cohort was 64.6�u9.9 years (range 20-88). Median BMI was 28.5�u5 kg/m2. Fever (81%) and dyspnea (65%) were the most common symptoms on admission. Most of patients (63%) had at least one co-existing disease. The 157 (82%) patients admitted to intensive care were more likely to be of intermediate age (60-69 years; OR 3.23, 95% CI 1.32-8.38), overweight (OR 2.66, 95% CI 1.02-7.07) or obese (OR 5.63, 95% CI 1.73-21.09) and with lymphocytopenia (OR 2.75, 95% CI 1.17-6.89) than the 34 patients admitted to the ordinary ward. During intensive care, 50% of patients died and their death was associated with older age (HR 2.06, 95% CI 1.07-3.97), obesity (HR 2.23, 95% CI 1.15-4.35) and male gender (HR 1.9, 95% CI 1.02-3.57). CONCLUSIONS: We found that admission to intensive care and poor survival were associated with advanced age and higher body mass index, albeit with differences in statistical significance. Pre-existing diseases and symptoms on admission were not associated with different clinical outcomes. Interestingly, male gender was more prevalent among SARS-CoV-2 patients and was related negatively to survival, but it was not associated with more frequent admission to intensive care.
AD  - Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. paolo.maltese@assomagi.org.
AN  - 33015815
AU  - Baronio, M.
AU  - Freni-Sterrantino, A.
AU  - Pinelli, M.
AU  - Natalini, G.
AU  - Tonini, G.
AU  - Marri, M.
AU  - Baglivo, M.
AU  - Sabatini, T.
AU  - Maltese, P. E.
AU  - Chiurazzi, P.
AU  - Michelini, S.
AU  - Morreale, G.
AU  - Ascione, A.
AU  - Notaro, P.
AU  - Bertelli, M.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23061
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Baronio, M
Freni-Sterrantino, A
Pinelli, M
Natalini, G
Tonini, G
Marri, M
Baglivo, M
Sabatini, T
Maltese, P E
Chiurazzi, P
Michelini, S
Morreale, G
Ascione, A
Notaro, P
Bertelli, M
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9698-9704. doi: 10.26355/eurrev_202009_23061.
PY  - 2020
SN  - 1128-3602
SP  - 9698-9704
ST  - Italian SARS-CoV-2 patients in intensive care: towards an identikit for subjects at risk?
T2  - European review for medical and pharmacological sciences
TI  - Italian SARS-CoV-2 patients in intensive care: towards an identikit for subjects at risk?
VL  - 24
ID  - 7785249
ER  - 

TY  - JOUR
AB  - Safety-net programs improve health for low-income children over the short and long term. In September 2018 the Trump administration announced its intention to change the guidance on how to identify a potential "public charge," defined as a noncitizen primarily dependent on the government for subsistence. After this change, immigrants' applications for permanent residence could be denied for using a broader range of safety-net programs. We investigated whether the announced public charge rule affected the share of children enrolled in Medicaid, the Supplemental Nutrition Assistance Program, and the Special Supplemental Nutrition Program for Women, Infants, and Children, using county-level data. Results show that a 1-percentage-point increase in a county's noncitizen share was associated with a 0.1-percentage-point reduction in child Medicaid use. Applied nationwide, this implies a decline in coverage of 260,000 children. The public charge rule was adopted in February 2020, just before the coronavirus disease 2019 (COVID-19) pandemic began in the US. These results suggest that the Trump administration's public charge announcement could have led to many thousands of eligible, low-income children failing to receive safety-net support during a severe health and economic crisis.
AD  - Jeremy Barofsky (jeremy@ideas42.org) is the vice president of applied research and evaluation at ideas42 in Madison, Wisconsin.
Ariadna Vargas is a project manager at ideas42 in Mexico City, Mexico.
Dinardo Rodriguez is an associate at ideas42 in New York, New York.
Anthony Barrows is a managing director at ideas42 in New York.
AN  - 33017237
AU  - Barofsky, J.
AU  - Vargas, A.
AU  - Rodriguez, D.
AU  - Barrows, A.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1377/hlthaff.2020.00763
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Health affairs (Project Hope)
LA  - eng
N1  - 1544-5208
Barofsky, Jeremy
Vargas, Ariadna
Rodriguez, Dinardo
Barrows, Anthony
Journal Article
United States
Health Aff (Millwood). 2020 Oct;39(10):1752-1761. doi: 10.1377/hlthaff.2020.00763.
PY  - 2020
SN  - 0278-2715
SP  - 1752-1761
ST  - Spreading Fear: The Announcement Of The Public Charge Rule Reduced Enrollment In Child Safety-Net Programs
T2  - Health affairs (Project Hope)
TI  - Spreading Fear: The Announcement Of The Public Charge Rule Reduced Enrollment In Child Safety-Net Programs
VL  - 39
ID  - 7785150
ER  - 

TY  - JOUR
AB  - Since the first governmental recognitions of the pandemic characteristic of the SARS-Cov-2 infections, public health agencies have warned about the dangers of the virus to persons with a variety of underlying physical conditions, many of which are more commonly found in persons older than 50 years old. To investigate the statistical, rather than physiological basis of such warnings, this study examines correlations on a nation-by-nation basis between the statistical data concerning covid-19 fatalities among the populations of the ninety-nine countries with the greatest number of SARS-Cov-2 infections plus the statistics of potential co-morbidities that may influence the severity of the infections. It examines reasons that may underlie of the degree to which advanced age increases the risk of mortality of an infection and contrasts the risk factors of SARS-Cov-2 infections with those of influenzas and their associated pneumonias.Competing Interest StatementThe authors have declared no competing interest.Funding StatementThis work is completely self supported without any outside funding.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:A data are from in the public domain All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data in this article are in the public domainhttps://www.worldometers.info/coronavirus/#countrieshttps://www.worldlifeexpectancy.com/
AU  - Barletta, William A.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.09.30.20204990
DP  - medRxiv
PY  - 2020
SP  - 2020.09.30.20204990
ST  - Epidemiological Risk Factors of SARS-Cov-2 Infections (preprint)
T2  - medRxiv
TI  - Epidemiological Risk Factors of SARS-Cov-2 Infections (preprint)
UR  - http://medrxiv.org/content/early/2020/10/02/2020.09.30.20204990.abstract
ID  - 7788885
ER  - 

TY  - JOUR
AB  - We evaluated saliva (SAL) specimens for SARS-CoV-2 RT-PCR testing by comparison of 459 prospectively paired nasopharyngeal (NP) or mid-turbinate (MT) swabs from 449 individuals with the aim of using saliva for asymptomatic screening. Samples were collected in a drive-through car line for symptomatic individuals (N=380) and in the emergency department (ED) (N=69). The percent positive and negative agreement of saliva compared to nasopharyngeal swab were 81.1% (95% CI: 65.8% �?90.5%) and 99.8% (95% CI: 98.7% �?100%), respectively. The sensitivity increased to 90.0% (95% CI: 74.4% �?96.5%) when considering only samples with moderate to high viral load (Cycle threshold (Ct) for the NP &amp;lt;=34). Pools of five saliva specimens were also evaluated on three platforms: bioMérieux NucliSENS easyMAG with ABI 7500Fast (CDC assay), Hologic Panther Fusion, and Roche COBAS 6800. The median loss of signal upon pooling was 2-4 Ct values across the platforms. The sensitivity of detecting a positive specimen in a pool compared with testing individually was 100%, 93%, and 95% for CDC 2019-nCoV Real-Time RT-PCR, Panther Fusion�] SARS-CoV-2 assay, and cobas�] SARS-CoV-2 test respectively, with decreased sample detection trending with lower viral load. We conclude that although pooled saliva testing, as collected in this study, is not quite as sensitive as NP/MT testing, saliva testing is adequate to detect individuals with higher viral loads in an asymptomatic screening program, does not require swabs or viral transport media for collection, and may help to improve voluntary screening compliance for those individuals averse to various forms of nasal collections.Competing Interest StatementThe authors have declared no competing interest.Clinical TrialNCT04424446Funding StatementWe declare that we have no conflicts of interest. This work was supported in part by the Intramural Research Program of the National Institutes of Health Clinical Center. This project has been funded in part with federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. 75N910D00024, Task Order No., Task Order No. 75N91019F00130. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. No other external funding was received for this study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:The study was approved by the IRB committees of both participating institutions.All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesAll data for this study are included in supplemental tubes S3-S6.
AU  - Barat, Bidisha
AU  - Das, Sanchita
AU  - Giorgi, Valeria De
AU  - Henderson, David K.
AU  - Kopka, Stacy
AU  - Lau, Anna Frances
AU  - Miller, Tracey
AU  - Moriarty, Theresa
AU  - Palmore, Tara N.
AU  - Sawney, Shari
AU  - Spalding, Christine D.
AU  - Tanjutco, Patricia
AU  - Wortmann, Glenn
AU  - Zelazny, Adrian M.
AU  - Frank, Karen M.
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20204859
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20204859
ST  - Pooled Saliva Specimens for SARS-CoV-2 Testing (preprint)
T2  - medRxiv
TI  - Pooled Saliva Specimens for SARS-CoV-2 Testing (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20204859.abstract
ID  - 7788867
ER  - 

TY  - JOUR
AB  - The outbreak of COVID-19 leads to emergence of the global pandemic, but there is no specific vaccine recommended for COVID-19. More than 216 countries are struggling against the transmission of the disease, recovery and motility. Till date more than 0.948 million deaths out of 30.369 million confirmed cases are reported by WHO. Most of the nations adopted partial or complete ‘lockdown�?and imposed ‘social distancing�?to control the rapid transmission of COVID-19 and its consequence. Though global economic growth declined due to nationwide lockdown, there are certain positive impacts on environment. This review article has discussed the effects of nationwide lockdown aiming to community transmission COVID-19 on animal life behaviour and atmospheric environment in different aspects. In the lockdown period, the levels of NO2 and carbon emission remarkably decrease in atmosphere due to restricted consumption of fossil fuel by industries, thermal power stations and air transportations. The concentration of NO2 dropped by 45�?4% in the atmosphere of most populated cities in Europe. The intensities of particulate matters PM2.5 and PM10 decreased by 43% and 31% respectively, at lower atmosphere indicating improvement in air qualities in different parts of world caused by less traffic and construction activities. SPM reduced up to 15.9%, showing improvement in surface water quality. New deserted bank has developed due to less river activities in this period. Noise pollution remarkably dropped below 60 db even in crowded cities. Thus, the atmospheric environment has resumed some extent in all respect by means of such global-wide lockdown aiming to control COVID-19 pandemic. The behavioural changes of wild animals, birds, butterfly, pets and street animals that reflected on ecosystem of their relative region indicate the non-interference of human activities on lives of natural creatures during lockdown period. There is certain correlation between atmospheric change with the behavioural changes of natural creature during lockdown period. The objective of this study is to focus the critical analysis of the effect of human activities on atmospheric environment for sustainable ecosystem in long term. Significantly, there is ample scope of research on sustainable development of atmospheric environment and ecosystem of creature in absence of human being. © 2020, Springer Nature B.V.
AD  - Department of Chemistry, Sabang Sajanikanta Mahavidyalaya, Lutunia, Paschim Medinipur, West Bengal 721166, India
AU  - Bar, H.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s10668-020-01002-7
J2  - Environ. Dev. Sustainability
KW  - Aquatic life
Atmospheric environment
COVID-19
Ecosystem
Lockdown
Wildlife
LA  - English
M3  - Review
N1  - Export Date: 6 October 2020
CODEN: EDSNB
Correspondence Address: Bar, H.; Department of Chemistry, Sabang Sajanikanta MahavidyalayaIndia; email: bar.krishna1981@gmail.com
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PY  - 2020
SN  - 1387585X (ISSN)
ST  - COVID-19 lockdown: animal life, ecosystem and atmospheric environment
T2  - Environment, Development and Sustainability
TI  - COVID-19 lockdown: animal life, ecosystem and atmospheric environment
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091726952&doi=10.1007%2fs10668-020-01002-7&partnerID=40&md5=e753c2129367eee10fb8fd1aedfd7c6a
ID  - 7783297
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) has infected millions of people worldwide and emerged to be the biggest global health threat claiming hundreds of thousands of lives at exponential rates. The severity of the disease increases with old age and presence of underlying health conditions, such as cancer. Managing cancer patients under these circumstances is rather challenging, given their compromised immunity and the overwhelmed health care services by COVID-19 community transmission. Thus, it is prudent to establish common guidelines for the monitoring and treatment of cancer patients. In this review, we comprehensively investigate the various aspects of cancer care during the COVID-19 pandemic, discuss challenges faced while treating cancer patients, and propose potential approaches to manage COVID-19 among this vulnerable population. We also discuss molecular aberrations and genetic changes associated with cancer and their role in affecting the virus' infectivity and severity. Lastly, we shed light on therapeutic approaches that can encompass both diseases without compromising one over the other.
AD  - Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut, Lebanon. GRID: grid.22903.3a. ISNI: 0000 0004 1936 9801
Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, 4300 Alton Rd, Miami Beach, FL 33140 USA. GRID: grid.410396.9. ISNI: 0000 0004 0430 4458
AN  - 33015555
AU  - Ballout, F.
AU  - Daouk, R.
AU  - Azar, J.
AU  - Timonian, M.
AU  - Araji, T.
AU  - Bahmad, H. F.
AU  - Abou-Kheir, W.
C1  - 10/6/2020
C2  - PMC7524598
DA  - Sep 30
DB  - PubMed
DO  - 10.1007/s42399-020-00549-w
DP  - NLM
ET  - 2020/10/06
J2  - SN comprehensive clinical medicine
KW  - Covid-19
Cancer
Immune response
SARS-CoV-2
Therapeutic target
LA  - eng
N1  - 2523-8973
Ballout, Farah
Daouk, Reem
Azar, Joseph
Timonian, Michael
Araji, Tarek
Bahmad, Hisham F
Orcid: 0000-0003-3799-2595
Abou-Kheir, Wassim
Journal Article
Review
SN Compr Clin Med. 2020 Sep 30:1-10. doi: 10.1007/s42399-020-00549-w.
PY  - 2020
SN  - 2523-8973
SP  - 1-10
ST  - Cancerona: Challenges of Cancer Management in Times of COVID-19 Pandemic
T2  - SN comprehensive clinical medicine
TI  - Cancerona: Challenges of Cancer Management in Times of COVID-19 Pandemic
ID  - 7785286
ER  - 

TY  - JOUR
AB  - OBJECTIVE: To monitor hospital activity for presentation, diagnosis and treatment of cardiovascular diseases during the COVID-19) pandemic to inform on indirect effects. METHODS: Retrospective serial cross-sectional study in nine UK hospitals using hospital activity data from 28 October 2019 (pre-COVID-19) to 10 May 2020 (pre-easing of lockdown) and for the same weeks during 2018-2019. We analysed aggregate data for selected cardiovascular diseases before and during the epidemic. We produced an online visualisation tool to enable near real-time monitoring of trends. RESULTS: Across nine hospitals, total admissions and emergency department (ED) attendances decreased after lockdown (23 March 2020) by 57.9% (57.1%-58.6%) and 52.9% (52.2%-53.5%), respectively, compared with the previous year. Activity for cardiac, cerebrovascular and other vascular conditions started to decline 1-2 weeks before lockdown and fell by 31%-88% after lockdown, with the greatest reductions observed for coronary artery bypass grafts, carotid endarterectomy, aortic aneurysm repair and peripheral arterial disease procedures. Compared with before the first UK COVID-19 (31 January 2020), activity declined across diseases and specialties between the first case and lockdown (total ED attendances relative reduction (RR) 0.94, 0.93-0.95; total hospital admissions RR 0.96, 0.95-0.97) and after lockdown (attendances RR 0.63, 0.62-0.64; admissions RR 0.59, 0.57-0.60). There was limited recovery towards usual levels of some activities from mid-April 2020. CONCLUSIONS: Substantial reductions in total and cardiovascular activities are likely to contribute to a major burden of indirect effects of the pandemic, suggesting they should be monitored and mitigated urgently.
AD  - University Hospitals Birmingham NHS Trust, Birmingham, United Kingdom.
Health Data Research UK Midlands, Birmingham, United Kingdom.
Institute of Health Informatics, University College London, London, United Kingdom ami.banerjee@ucl.ac.uk cathie.sudlow@hdruk.ac.uk.
University College London Hospitals NHS Trust, London, United Kingdom.
Health Data Research UK, London, United Kingdom.
BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Department of Cardiology, Golden Jubilee National Hospital, Clydebank, UK.
University of Cambridge, Cambridge, Cambridgeshire, UK.
Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
IQVIA Ltd, Reading, UK.
Department of Cardiology, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK.
Health Data Research UK Cambridge, Cambridge, UK.
Barnsley Hospital NHS Foundation Trust, Barnsley, South Yorkshire, UK.
Royal Papworth Hospital NHS Foundation Trust, Cambridge, Cambridgeshire, UK.
The University of Edinburgh Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK.
University of Dundee Health Informatics Centre, Dundee, UK.
Institute of Health Informatics, University College London, London, United Kingdom.
Population Health and Genomics, University of Dundee, Dundee, UK.
Health Data Research UK Scotland, Edinburgh, United Kingdom.
University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.
Centre for Cardiovascular Sciences, The University of Edinburgh, Edinburgh, UK.
Health Data Research UK North, Sheffield, UK.
School of Health and Related Research, University of Sheffield, Sheffield, United Kingdom.
BHF Centre for Cardiovascular Sciences, The University of Edinburgh, Edinburgh, UK.
Institute of Translational Medicine, University of Liverpool, Liverpool, UK.
Cancer Research UK Edinburgh Centre, Institute of Genomic and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
BHF Data Science Centre, Health Data Research UK, London, UK.
BHF/University Centre for Cardiovascular Science, Royal Infirmary of Edinburgh, Edinburgh, UK.
Institute of Health Informatics, University College London, London, UK.
Health Data Research UK South West, Population Health Sciences, University of Bristol, Bristol, UK.
British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK.
The University of Edinburgh Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK ami.banerjee@ucl.ac.uk cathie.sudlow@hdruk.ac.uk.
The University of Edinburgh Centre for Clinical Brain Sciences, Edinburgh, UK.
AN  - 33020224
AU  - Ball, S.
AU  - Banerjee, A.
AU  - Berry, C.
AU  - Boyle, J.
AU  - Bray, B.
AU  - Bradlow, W.
AU  - Chaudhry, A.
AU  - Crawley, R.
AU  - Danesh, J.
AU  - Denniston, A.
AU  - Falter, F.
AU  - Figueroa, J. D.
AU  - Hall, C.
AU  - Hemingway, H.
AU  - Jefferson, E.
AU  - Johnson, T.
AU  - King, G.
AU  - Lee, K. K.
AU  - McKean, P.
AU  - Mason, S.
AU  - Mills, N. L.
AU  - Pearson, E.
AU  - Pirmohamed, M.
AU  - Poon, M. T. C.
AU  - Priedon, R.
AU  - Shah, A.
AU  - Sofat, R.
AU  - Sterne, J. A. C.
AU  - Strachan, F. E.
AU  - Sudlow, C. L. M.
AU  - Szarka, Z.
AU  - Whiteley, W.
AU  - Wyatt, M.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/heartjnl-2020-317870
DP  - NLM
ET  - 2020/10/07
J2  - Heart (British Cardiac Society)
KW  - aortic and arterial disease
epidemiology
global health care delivery
health care delivery
heart disease
LA  - eng
N1  - 1468-201x
Ball, Simon
Banerjee, Amitava
Orcid: 0000-0001-8741-3411
Berry, Colin
Orcid: 0000-0002-4547-8636
Boyle, Jonathan
Bray, Benjamin
Bradlow, William
Chaudhry, Afzal
Crawley, Rikki
Danesh, John
Denniston, Alastair
Falter, Florian
Figueroa, Jonine D
Hall, Christopher
Hemingway, Harry
Orcid: 0000-0003-2279-0624
Jefferson, Emily
Johnson, Tom
King, Graham
Lee, Kuan Ken
Orcid: 0000-0003-3404-4098
McKean, Paul
Mason, Suzanne
Mills, Nicholas L
Orcid: 0000-0003-0533-7991
Pearson, Ewen
Pirmohamed, Munir
Poon, Michael T C
Orcid: 0000-0002-0053-2184
Priedon, Rouven
Shah, Anoop
Sofat, Reecha
Sterne, Jonathan A C
Strachan, Fiona E
Sudlow, Cathie L M
Szarka, Zsolt
Whiteley, William
Wyatt, Michael
CVD-COVID-UK Consortium
Journal Article
England
Heart. 2020 Oct 5:heartjnl-2020-317870. doi: 10.1136/heartjnl-2020-317870.
PY  - 2020
SN  - 1355-6037
ST  - Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK
T2  - Heart (British Cardiac Society)
TI  - Monitoring indirect impact of COVID-19 pandemic on services for cardiovascular diseases in the UK
ID  - 7785043
ER  - 

TY  - JOUR
AB  - While the coronavirus pandemic has spread around the world like wildfire since almost 7 months of its emergence, domestic violence has been breeding endlessly like a "silent pandemic" and is similarly globally persevered. Violence against women exacerbates during such emergencies on account of heightened tension and close living conditions due to lockdowns regulated by state orders. In Pakistan, where domestic violence is a "taboo" object of discussion, help is not provided from neighboring citizens, or even by law enforcers, leaving victims to endure in solitude acts of verbal, physical, psychological, and sexual abuse in the name of alleged supremacy of the assailant.
AD  - Ziauddin Medical University, Karachi, Pakistan.
AN  - 33016092
AU  - Baig, M. A. M.
AU  - Ali, S.
AU  - Tunio, N. A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/1010539520962965
DP  - NLM
ET  - 2020/10/06
J2  - Asia-Pacific journal of public health
KW  - Covid-19
Pakistan
domestic violence
lockdown
women’s health/violence
LA  - eng
N1  - 1941-2479
Baig, Mirza Altamish Muhammad
Orcid: 0000-0001-7079-1328
Ali, Sajjad
Orcid: 0000-0002-8024-5942
Tunio, Numra Altaf
Orcid: 0000-0001-5458-3780
Journal Article
China
Asia Pac J Public Health. 2020 Oct 5:1010539520962965. doi: 10.1177/1010539520962965.
PY  - 2020
SN  - 1010-5395
SP  - 1010539520962965
ST  - Domestic Violence Amid COVID-19 Pandemic: Pakistan's Perspective
T2  - Asia-Pacific journal of public health
TI  - Domestic Violence Amid COVID-19 Pandemic: Pakistan's Perspective
ID  - 7785223
ER  - 

TY  - JOUR
AB  - BACKGROUND: Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby improving outcomes and facilitating future research. METHODS: An International Task Force was composed and agreement regarding courses of action was measured using the Convergence of Opinion on Recommendations and Evidence (CORE) process. 70% agreement was necessary to make a consensus suggestion. RESULTS: The Task Force made consensus suggestions to treat patients with acute COVID-19 pneumonia with remdesivir and dexamethasone but suggested against hydroxychloroquine except in the context of a clinical trial; these are revisions of prior suggestions resulting from the interim publication of several randomised trials. It also suggested that COVID-19 patients with a venous thromboembolic event be treated with therapeutic anticoagulant therapy for 3 months. The Task Force was unable to reach sufficient agreement to yield consensus suggestions for the post-hospital care of COVID-19 survivors. The Task Force fell one vote shy of suggesting routine screening for depression, anxiety and post-traumatic stress disorder. CONCLUSIONS: The Task Force addressed questions related to pharmacotherapy in patients with COVID-19 and the post-hospital care of survivors, yielding several consensus suggestions. Management options for which there is insufficient agreement to formulate a suggestion represent research priorities.
AD  - Dept of Pulmonary and Critical Care Medicine, Zhongshan Hospital Fudan University, Shanghai, China.
Shanghai Respiratory Research Institution, Shanghai, China.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
Vall d'Hebron Research Institute, Barcelona, Spain.
Centro de Investigaci�Qn Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
CHU Nîmes, Nîmes, France.
Division of Pulmonary and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Dept of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Center for Rare Lung Diseases, Dept of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark.
Dept of Respiratory Medicine, Cochin Hospital, Assistance Publique Hopîtaux de Paris, Université de Paris and Institut Cochin, Inserm U1016, Paris, France.
Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.
Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Internal Medicine, Stony Brook University, Stony Brook, NY, USA.
Dept of Medicine, Veterans Affairs Puget Sound Health Care System and University of Washington, Seattle WA, USA.
Dept of Critical Care, Cleveland Clinic, Cleveland OH, USA.
Division of Pulmonary and Critical Care Medicine, Dept of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Dept of Anesthesia and Intensive Care Medicine, Galway University Hospitals, National University of Ireland, Galway, Ireland.
Dept of Medicine, Pulmonary Diseases Division, Hospital de Cl�Tnicas, Universidad de Buenos Aires, Buenos Aires, Argentina.
Division of Pulmonary and Critical Care, Dept of Medicine, Weill Cornell Medicine, New York NY, USA.
Dept of Medicine, University of Washington, Seattle WA, USA.
Division of Infectious Diseases, Dept of Medicine, University of Louisville, Louisville KY, USA.
Critical Care Dept, Vall d'Hebron University Hospital Barcelona, Barcelona, Spain.
Dept de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Division of Pulmonary, Critical Care, and Sleep Medicine, Spectrum Health-Michigan State University, Grand Rapids MI, USA.
Pulmonology Dept, University of Barcelona Hospital Clinic of Barcelona, IDIBAPS, Barcelona, Spain.
Dept of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.
Division of Infectious Diseases, Cleveland Clinic Akron General, Akron, OH, USA.
Respiratory Dept, Vall d'Hebron University Hospital, Barcelona, Spain.
Centro de Investigaci�Qn Biomédica en Red de Enfermedades Respiratorias (Ciberes), Madrid, Spain.
UOC Anestesia e Rianimazione 1, IRCCS Policlinico San Matteo, Pavia, Italy.
Dept of Medicine, American University of Beirut, Beirut, Lebanon.
Dept of Pulmonary and Critical Care Medicine, Shenzhen Institute of Respiratory Disease, Shenzhen People's Hospital, First Affiliated Hospital of South University of Science and Technology of China, Shenzhen, China.
Dept of Pulmonary Medicine, Mayo Clinic, Rochester MN, USA.
Dept of Medicine, Pulmonary, Critical Care, and Sleep Medicine, Yale University School of Medicine, New Haven CT, USA.
Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston MA, USA.
Dept of Intensive Care, Amsterdam University Medical Center, Amsterdam, The Netherlands.
Division of Pulmonary and Critical Care, Dept of Medicine, Oregon Health Sciences University, Portland, OR, USA.
Dept of Medicine, Robert Wood Johnson University Hospital, New Brunswick NJ, USA.
Division of Pulmonary and Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Dept of Radiology, Kansai Rosai Hospital, Amagaski, Japan.
Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Internal Medicine, University of Southern California, Los Angeles CA, USA.
Department of Respiratory Medicine, Beaumont Hospital, Royal College of Surgeons in Ireland, Dublin, Ireland.
Dept of Respiratory Medicine, Galway University Hospitals, National University of Ireland, Galway, Ireland.
Institute of Infectious Diseases and Infection Control, Jena University Hospital/Friedrich-Schiller-University, Jena, Germany.
Division of Pulmonary, Allergy and Critical Care Medicine, Dept of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
Dept of Anesthesia and Critical Care, Ospedale Maggiore di Lodi, Lodi, Italy.
Dept of Medicine, Medical University of South Carolina, Charleston SC, USA.
Division of Pulmonary and Critical Care Medicine, Mount Auburn Hospital, Cambridge MA, Harvard Medical School, Boston MA, USA.
Infection Prevention and Clinical Epidemiology Unit at UC San Diego Health, Division of Infectious Diseases and Global Public Health, Department of Medicine, UC San Diego, San Diego CA, USA.
Dept of Pulmonary and Critical Care Medicine, The Affiliated Wuxi No.2 People's Hospital of Nanjing Medical University, Wuxi, China.
Dept of Respiratory Medicine, University Hospitals Leuven, Leuven, Belgium.
Dept of Pulmonary and Critical Care Medicine, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Dept of Pulmonary and Critical Care Medicine, Tongji Hospital Tongji University, Shanghai, China.
Dept of Medicine, Boston University School of Medicine, Boston, MA, USA kwilson@thoracic.org.
AN  - 33020069
AU  - Bai, C.
AU  - Chotirmall, S. H.
AU  - Rello, J.
AU  - Alba, G. A.
AU  - Ginns, L. C.
AU  - Krishnan, J. A.
AU  - Rogers, R.
AU  - Bendstrup, E.
AU  - Burgel, P. R.
AU  - Chalmers, J. D.
AU  - Chua, A.
AU  - Crothers, K. A.
AU  - Duggal, A.
AU  - Kim, Y. W.
AU  - Laffey, J. G.
AU  - Luna, C. M.
AU  - Niederman, M. S.
AU  - Raghu, G.
AU  - Ramirez, J. A.
AU  - Riera, J.
AU  - Roca, O.
AU  - Tamae-Kakazu, M.
AU  - Torres, A.
AU  - Watkins, R. R.
AU  - Barrecheguren, M.
AU  - Belliato, M.
AU  - Chami, H. A.
AU  - Chen, R.
AU  - Cortes-Puentes, G. A.
AU  - Delacruz, C.
AU  - Hayes, M. M.
AU  - Heunks, L. M. A.
AU  - Holets, S. R.
AU  - Hough, C. L.
AU  - Jagpal, S.
AU  - Jeon, K.
AU  - Johkoh, T.
AU  - Lee, M. M.
AU  - Liebler, J.
AU  - McElvaney, G. N.
AU  - Moskowitz, A.
AU  - Oeckler, R. A.
AU  - Ojanguren, I.
AU  - O'Regan, A.
AU  - Pletz, M. W.
AU  - Rhee, C. K.
AU  - Schultz, M. J.
AU  - Storti, E.
AU  - Strange, C.
AU  - Thomson, C. C.
AU  - Torriani, F. J.
AU  - Wang, X.
AU  - Wuyts, W.
AU  - Xu, T.
AU  - Yang, D.
AU  - Zhang, Z.
AU  - Wilson, K. C.
C1  - 10/6/2020
DA  - Sep 30
DB  - PubMed
DO  - 10.1183/16000617.0287-2020
DP  - NLM
ET  - 2020/10/07
IS  - 157
J2  - European respiratory review : an official journal of the European Respiratory Society
LA  - eng
N1  - 1600-0617
Bai, Chunxue
Orcid: 0000-0001-5798-3130
Chotirmall, Sanjay H
Orcid: 0000-0003-0417-7607
Rello, Jordi
Orcid: 0000-0003-0676-6210
Alba, George A
Orcid: 0000-0002-6876-7836
Ginns, Leo C
Krishnan, Jerry A
Rogers, Robert
Bendstrup, Elisabeth
Orcid: 0000-0002-4238-6963
Burgel, Pierre-Regis
Orcid: 0000-0003-0903-9828
Chalmers, James D
Chua, Abigail
Crothers, Kristina A
Duggal, Abhijit
Kim, Yeon Wook
Orcid: 0000-0001-8333-4812
Laffey, John G
Orcid: 0000-0002-1246-9573
Luna, Carlos M
Orcid: 0000-0002-9288-096x
Niederman, Michael S
Raghu, Ganesh
Ramirez, Julio A
Riera, Jordi
Orcid: 0000-0002-1738-4448
Roca, Oriol
Tamae-Kakazu, Maximiliano
Orcid: 0000-0003-4943-1656
Torres, Antoni
Orcid: 0000-0002-8643-2167
Watkins, Richard R
Barrecheguren, Miriam
Belliato, Mirko
Chami, Hassan A
Chen, Rongchang
Cortes-Puentes, Gustavo A
Delacruz, Charles
Hayes, Margaret M
Heunks, Leo M A
Holets, Steven R
Hough, Catherine L
Jagpal, Sugeet
Jeon, Kyeongman
Orcid: 0000-0002-4822-1772
Johkoh, Takeshi
Lee, May M
Orcid: 0000-0001-7899-0401
Liebler, Janice
McElvaney, Gerry N
Moskowitz, Ari
Orcid: 0000-0002-0194-990x
Oeckler, Richard A
Ojanguren, Iñigo
O'Regan, Anthony
Pletz, Mathias W
Orcid: 0000-0001-8157-2753
Rhee, Chin Kook
Orcid: 0000-0003-4533-7937
Schultz, Marcus J
Storti, Enrico
Strange, Charlie
Thomson, Carey C
Torriani, Francesca J
Wang, Xun
Wuyts, Wim
Orcid: 0000-0001-9648-3497
Xu, Tao
Orcid: 0000-0001-7544-0551
Yang, Dawei
Zhang, Ziqiang
Wilson, Kevin C
Journal Article
Review
England
Eur Respir Rev. 2020 Oct 5;29(157):200287. doi: 10.1183/16000617.0287-2020. Print 2020 Sep 30.
PY  - 2020
SN  - 0905-9180
ST  - Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020)
T2  - European respiratory review : an official journal of European Respiratory Society
TI  - Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020)
VL  - 29
ID  - 7785057
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is affiliated with the β-coronavirus subgroup, which includes SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but is far more infectious than the 2. Because it is potentially life-threatening to infants and pregnant women with weak immune systems, clinical manifestations and vertical transmission of COVID-19 are matters of interest. Staff of the obstetrics department of university hospitals in Daegu and of the Daegu metropolitan government designated Daegu Fatima Hospital for the delivery of pregnant women with suspected and confirmed SARS-CoV-2 infection. Thirteen pregnant women with laboratory-confirmed COVID-19 were identified. Among them was a 28-year-old pregnant woman who had recovered from COVID-19 and had given birth to a healthy girl at 38 weeks of gestational age. We present our uncommon experience with a brief review of literatures.
AD  - Department of Obstetrics and Gynecology, Keimyung University School of Medicine, Daegu, Korea.
Department of Obstetrics and Gynecology, Fatima Hospital, Daegu, Korea.
Department of Obstetrics and Gynecology, Graduate School of Medicine, Kyungpook National University, Daegu, Korea.
Department of Obstetrics and Gynecology, Catholic University of Daegu School of Medicine, Daegu, Korea.
AN  - 33012160
AU  - Bae, J. G.
AU  - Ha, J. K.
AU  - Kwon, M.
AU  - Park, H. Y.
AU  - Seong, W. J.
AU  - Hong, S. Y.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.5468/ogs.20106
DP  - NLM
ET  - 2020/10/06
J2  - Obstetrics & gynecology science
KW  - Covid-19
Coronavirus
Obstetric delivery
Pregnancy
LA  - eng
N1  - Bae, Jin-Gon
Ha, Jin-Kyeong
Kwon, Myoung
Park, Hak-Youle
Seong, Won-Joon
Hong, Seong-Yeon
Journal Article
Korea (South)
Obstet Gynecol Sci. 2020 Oct 5. doi: 10.5468/ogs.20106.
PY  - 2020
SN  - 2287-8572 (Print)
2287-8572
ST  - A case of delivery of a pregnant woman with COVID-19 infection in Daegu, Korea
T2  - Obstetrics & gynecology science
TI  - A case of delivery of a pregnant woman with COVID-19 infection in Daegu, Korea
ID  - 7785615
ER  - 

TY  - JOUR
AU  - Bacq, Sophie
AU  - Lumpkin, G. T.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Social Entrepreneurship and COVID-19
T2  - Journal of Management Studies
TI  - Social Entrepreneurship and COVID-19
UR  - https://doi.org/10.1111/joms.12641
ID  - 7788288
ER  - 

TY  - JOUR
AU  - Bacon, D.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1177/1095796020950695
IS  - 3
J2  - New Labor Forum
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Bacon, D.email: dbacon@igc.org
PY  - 2020
SN  - 10957960 (ISSN)
SP  - 38-41
ST  - Courage in the Time of Covid-19: Amazon Warehouse, May Day 2020
T2  - New Labor Forum
TI  - Courage in the Time of Covid-19: Amazon Warehouse, May Day 2020
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091721186&doi=10.1177%2f1095796020950695&partnerID=40&md5=1b3aa636fb0178128b5b2d305505a962
VL  - 29
ID  - 7783213
ER  - 

TY  - JOUR
AB  - Latar BelakangSebanyak 38.6% kasus kematian pasien COVID-19 di Indonesia terjadi di populasi lansia. Data mengenai profil klinis pasien rawat inap lansia dengan COVID-19 masih tidak ada. Padahal kelompok pasien ini adalah pasien risiko tinggi selama pandemi ini yang memerlukan perhatian lebih.MetodeStudi deskriptif ini menggunakan data lengkap pasien lansia dengan COVID-19 yang dirawat inap di Rumah Sakit Umum Pusat Nasional Cipto Mangunkusumo (RSUPN Cipto Mangunkusumo) dari April hingga akhir Agustus 2020. Data termasuk karakteristik klinis, gejala, komorbiditas, multimorbiditas dan luaran mortalitas pasien.HasilDi populasi pasien lansia (n=44), mayoritas berusia di antara 60-69 tahun (68%), berjenis kelamin laki-laki (66%), dan tidak memiliki riwayat kontak erat dengan pasien COVID-19 sebelumnya (86%). Gejala tersering ialah demam, batuk, dan sesak yang merupakan gejala khas COVID-19, sedangkan penyakit kronis tersering adalah diabetes melitus, hipertensi, dan keganasan. Multimorbiditas ditemukan hanya di 14% pasien lansia, dan para pasien tersebut bertahan hidup pasca infeksi virus SARS-CoV-2. Angka kematian pasien lansia rawat inap dengan COVID-19 di studi ini adalah 23%, dan 90% dari kasus kematian berjenis kelamin laki-laki.KesimpulanPasien laki-laki mendominasi kasus terkonfirmasi dan kasus kematian lansia dengan COVID-19. Gejala khas COVID-19 hanya ditemukan di sekitar setengah pasien penelitian. Pasien yang meninggal dunia memiliki persentase gejala khas lebih tinggi. Gejala tidak khas pun mungkin ditemukan di pasien lansia. Immunosenescence dan fungsi imunoregulasi jenis kelamin tertentu dihipotesiskan memiliki peran penting dalam menyebabkan kematian lansia di studi ini.Kata Kunci: Profil Klinis, Lansia, Pasien Geriatri, COVID-19, Indonesia  ABSTRACTBackgroundOlder people contributed to 38.6% of death cases related to COVID-19 in Indonesia. Data regarding clinical profile of hospitalised elderly with COVID-19 in Indonesia were still lacking. Older people are at-risk population in the pandemic, whom we should pay attention to.MethodsThis single centre descriptive study utilised complete data of elderly inpatients with COVID-19 in Indonesia's national general hospital from April to late August 2020. The data consisted of clinical characteristics, symptoms, comorbidities, multimorbidity, and mortality outcome.ResultsAmong elderly patients (n=44), a majority of patients were aged 60-69 years (68%), were male (66%), and had no history of close contact with COVID-19 patient (86%). The most common symptoms were fever, cough and shortness of breath (classic symptoms of COVID-19), whereas the most common chronic diseases were diabetes mellitus, hypertension, and malignancy. Multimorbidity was only found in 14% of patients, all of whom remained alive following SARS-CoV-2 infection. The death rate among elderly inpatients with COVID-19 in this study was 23%, and male older adults contributed to 90% of death cases.ConclusionMale patients dominated both confirmed cases and death cases among elderly with COVID-19. Classic symptoms of COVID-19 were only found in about half of the study patients. Non-survivors had higher percentage of the classic symptoms of COVID-19 than survivors. Atypical COVID-19 presentations are possible in older adults. We postulated that immunosenescence and sex-specific immunoregulatory function play an important role in causing death in this study cohort. Keywords: Clinical Profile, Elderly, Geriatric Patient, COVID-19, Indonesia.
AD  - Faculty of Medicine, Universitas Indonesia. khifzhon@gmail.com.
AN  - 33020331
AU  - Azwar, M. K.
AU  - Setiati, S.
AU  - Rizka, A.
AU  - Fitriana, I.
AU  - Saldi, S. R. F.
AU  - Safitri, E. D.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
Clinical Profile
Elderly
Geriatric Patient
Indonesia
LA  - eng
N1  - Azwar, Muhammad Khifzhon
Setiati, Siti
Rizka, Aulia
Fitriana, Ika
Saldi, Siti Rizny F
Safitri, Eka Dian
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):199-205.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 199-205
ST  - Clinical Profile of Elderly Patients with COVID-19 hospitalised in Indonesia's National General Hospital
T2  - Acta medica Indonesiana
TI  - Clinical Profile of Elderly Patients with COVID-19 hospitalised in Indonesia's National General Hospital
VL  - 52
ID  - 7785037
ER  - 

TY  - JOUR
AB  - Coronavirus associated severe acute respiratory syndrome (SARS-CoV-2) causes a worldwide syndrome called Covid-19 that has caused 5,940,441 infections and 362,813 deaths until May 2020. In moderate and severe stages of the infection a generalized swelling, cytokine storm and an increment of the heart damage biomarkers occur. In addition, a relation between Covid-19 and neurological symptoms have been suggested. The results of autopsies suggest thrombotic microangiopathy in multiple organs. We present 2 cases of patients infected with severe Covid-19 that were hospitalized in the Reanimation Unit that presented cerebrovascular symptoms and died afterwards. A high dose prophylaxis with antithrombotic medication is recommended in patients affected by moderate to severe Covid-19.
AD  - Servicio de Anestesia y Reanimaci�Qn, Hospital de Galdakao, Galdakao, Bizkaia, España. Electronic address: azpilandan@gmail.com.
Servicio de Anestesia y Reanimaci�Qn, Hospital de Galdakao, Galdakao, Bizkaia, España.
AN  - 33012537
AU  - Azpaiazu Landa, N.
AU  - Velasco Oficialdegui, C.
AU  - Intxaurraga Fern֙ndez, K.
AU  - Gonzalez Larrabe, I.
AU  - Riaño Onaindia, S.
AU  - Telletxea Benguria, S.
C1  - 10/6/2020
DA  - Oct 1
DB  - PubMed
DO  - 10.1016/j.redar.2020.08.002
DP  - NLM
ET  - 2020/10/06
J2  - Revista espanola de anestesiologia y reanimacion
KW  - Accidente cerebrovascular
Afectaci�Qn cardiovascular
Anticoagulaci�Qn
Anticoagulation
Cardiovascular affectation
Covid-19
Microangiopat�Ta tromb�Qtica
Neurology
Neurolog�Ta
SARS-CoV-2
Stroke
Thrombosis
Thrombotic microangiopathy
Trombosis
LA  - eng
spa
N1  - 2340-3284
Azpaiazu Landa, N
Velasco Oficialdegui, C
Intxaurraga Fern֙ndez, K
Gonzalez Larrabe, I
Riaño Onaindia, S
Telletxea Benguria, S
Case Reports
Spain
Rev Esp Anestesiol Reanim. 2020 Oct 1:S0034-9356(20)30199-7. doi: 10.1016/j.redar.2020.08.002.
OP  - Afectaci�Qn cerebrovascular isquémico-hemorr֙gica en pacientes con covid-19.
PY  - 2020
SN  - 0034-9356
ST  - Ischemic-hemorrhagic stroke in patients with Covid-19
T2  - Revista espanola de anestesiologia y reanimacion
TI  - Ischemic-hemorrhagic stroke in patients with Covid-19
ID  - 7785572
ER  - 

TY  - JOUR
AB  - Corona virus disease (COVID 19) is an infectious respiratory disease caused by the novel virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With many countries implementing lockdown the surgical activities in the division of otolaryngology across the world has been affected with many hospital confining themselves to only emergency or essential surgeries. The aim of this work is to report and discuss the in the surgical activity of the otolaryngology unit of the St John's National Academy of Health Sciences, Bangalore (India) during the pandemic. We performed acute and subacute emergencies which include diagnosis and treatment of malignant tumors of the head and neck, management of airway emergencies in adults and children, drainage of abscesses of the head and neck, Foreign body removal, emergency nasal debridement and surgeries for the unsafe ear. With the pandemic the surgical activities in otolaryngology changed drastically and with strict protocol and triaging put in place the risk for Health care workers was avoided and services to patients delivered.
AD  - Department of ENT, St John's National Academy of Health Sciences, Sarjapur Road, Bangalore, Karnataka 560034 India. GRID: grid.418280.7. ISNI: 0000 0004 1794 3160
AN  - 33020733
AU  - Atru, B.
AU  - Sutrave, M.
AU  - George, R.
AU  - James, R.
AU  - Ross, A.
AU  - C, B. P.
C1  - 10/6/2020
C2  - PMC7528446
DA  - Oct 1
DB  - PubMed
DO  - 10.1007/s12070-020-02155-7
DP  - NLM
ET  - 2020/10/07
J2  - Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
KW  - Aerosol generating procedure
Covid 19
Tracheostomy
Triage
LA  - eng
N1  - Atru, Balasubramanyam
Sutrave, Mithun
Orcid: 0000-0003-3355-5582
George, Rani
James, Rhea
Ross, Anita
C B, Pratibha
Journal Article
India
Indian J Otolaryngol Head Neck Surg. 2020 Oct 1:1-6. doi: 10.1007/s12070-020-02155-7.
PY  - 2020
SN  - 2231-3796 (Print)
2231-3796
SP  - 1-6
ST  - Otolaryngology Surgical Activity in Tertiary Care Center During the Covid-19 Lockdown
T2  - Indian journal of otolaryngology and head and neck surgery : official publication of Association of Otolaryngologists of India
TI  - Otolaryngology Surgical Activity in Tertiary Care Center During the Covid-19 Lockdown
ID  - 7784991
ER  - 

TY  - JOUR
AB  - Since the WHO declared coronavirus disease 2019 (COVID-19) as a pandemic, huge efforts were made to understand the disease, its pathogenesis, and treatment. COVID-19 is caused by severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2), which is closely related to SARS-associated coronavirus (SARS-CoV). This article attempts to provide a timely and comprehensive review of the coronaviruses over the years, and the epidemics they caused in this century with a focus on the current pandemic COVID-19. It also covers the basics about the disease immunopathogenesis, diagnosis, prognosis, and treatment options. Although almost every single week new clinical findings are published, which change our understanding of COVID-19, this review explores and explains the disease and the treatment options available so far. In summary, many therapeutic options are being investigated to treat and/or ameliorate the symptoms of COVID-19, but none is registered and no sufficient data to support immune-based therapy beyond the context of clinical trials. For that, strengthening our immune system is the best defense at this time.
AD  - Department of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, The University of Jordan, Amman, Jordan.
AN  - 33017280
AU  - Assaf, A. M.
AU  - Haddadin, R. N.
AU  - Akour, A. A.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1089/vim.2020.0102
DP  - NLM
ET  - 2020/10/06
J2  - Viral immunology
KW  - Covid-19
SARS-CoV2
coronavirus
cytokine storm
immunopathology
therapy
LA  - eng
N1  - 1557-8976
Assaf, Areej M
Haddadin, Randa N
Akour, Amal A
Journal Article
United States
Viral Immunol. 2020 Oct 5. doi: 10.1089/vim.2020.0102.
PY  - 2020
SN  - 0882-8245
ST  - COVID-19: Between Past and Present
T2  - Viral immunology
TI  - COVID-19: Between Past and Present
ID  - 7785145
ER  - 

TY  - JOUR
AB  - Background: SARS-CoV-2 causes COVID19 disease where there are no suitable drugs available. Objective(s): The objective of the work is to repurpose the drugs prescribed for SARS-CoV as the drugs for the control of SARS-CoV-2. Method(s): In this work, we have used homology searches and docking methods for understanding the mechanism of the drugs prescribed for the control of SARS-CoV on SARS-CoV-2. Result(s): In our analysis, we found that the drugs Benzyl (2-Oxopropyl)carbamate, 2-[(2,4-Dichloro-5-methyl phenyl)sulfonyl]-1,3-dinitro-5-(trifluoromethyl)benzene, S-[5-(Trifluoromethyl)-4H-1,2,4-triazol-3-YL] 5-(phenylethynyl)furan-2-carbothioate, 4-(Dimethylamino)benzoic acid, which are capable of inhibition of the activity of 3CLsupPro/sup and prevent the progression of SARS-CoV. Conclusion(s): In this letter, we describe the findings of the protein ligand interactions between 3CLsupPro/sup of SARS-CoV, SARS-CoV-2 with Benzyl (2-oxopropyl) carbamate. Copyright © 2020 Bentham Science Publishers.
AD  - (Arun) Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad, Telangana, India (Hussain) Department of Botany, Aligarh Muslim University, Aligarh, Uttar Pradesh, India (Akhter) Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Vidya Vihar, Raebareli Road, Lucknow, India (Rao) Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, India (Shyam) Department of Biotechnology, National Institute of Technology, Warangal, Telangana, India (Yellaboina) Department of Medical Elementology and Toxicology, Jamia Hamdard University, New Delhi, India
P.V.P.S. Arun, Department of Biotechnology, Chaitanya Bharathi Institute of Technology, Hyderabad, Telangana, India. E-mail: arun.uoh@gmail.com
AN  - 2005142600
AU  - Arun, P. V. P. S.
AU  - Hussain, R.
AU  - Akhter, Y.
AU  - Rao, M. V. B.
AU  - Shyam, P.
AU  - Yellaboina, S.
C1  - 10/6/2020
DB  - Embase
DO  - http://dx.doi.org/10.2174/1570180817999200730190600
DP  - Ovid Technologies
IS  - 10
KW  - 3CLsuppro/sup
Benzyl(2-oxopropyl) carbamate
Drugs
Repurposing
SARS-CoV
SARS-CoV-2
controlled study
letter
nonhuman
Severe acute respiratory syndrome coronavirus 2
unclassified drug
LA  - English
M3  - Letter
PY  - 2020
SN  - 1570-1808
1875-628X
SP  - 1325-1327
ST  - Drug re-purposing from SARS-CoV led the identification of potential candidate drug target and alternate drug molecules against SARS-CoV-2
T2  - Letters in Drug Design and Discovery
TI  - Drug re-purposing from SARS-CoV led the identification of potential candidate drug target and alternate drug molecules against SARS-CoV-2
UR  - http://www.eurekaselect.com/634/journal/letters-drug-design-amp-discovery
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005142600
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.2174%2F1570180817999200730190600&issn=1570-1808&isbn=&volume=17&issue=10&spage=1325&pages=1325-1327&date=2020&title=Letters+in+Drug+Design+and+Discovery&atitle=Drug+re-purposing+from+SARS-CoV+led+the+identification+of+potential+candidate+drug+target+and+alternate+drug+molecules+against+SARS-CoV-2&aulast=Arun&pid=%3Cauthor%3EArun+P.V.P.S.%2CHussain+R.%2CAkhter+Y.%2CRao+M.V.B.%2CShyam+P.%2CYellaboina+S.%3C%2Fauthor%3E&%3CAN%3E2005142600%3C%2FAN%3E&%3CDT%3ELetter%3C%2FDT%3E
VL  - 17
ID  - 7783009
ER  - 

TY  - JOUR
AB  - When reading the opening material in the July/August 2020 edition (Covid-19 workstreams), the one thing that struck me was what seems to be the unintended low value Diversity and Inclusion is given Reading the other workstreams, they are being led by professors, doctors, Lead Clinical Consultants, Presidents of the BPS, yet the Diversity and Inclusion workstream is represented by a student Please, this is not focused on the individuals mentioned - instead, it is based on the titles of the individuals and how these titles attribute standing and stature within and outside the psychology community
AU  - Artus, Tim
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Own goal or progress?
T2  - Psychologist
TI  - Own goal or progress?
UR  - https://search.bvsalud.org/global-literature-on-novel-coronavirus-2019-ncov/resource/en/covidwho-813014
ID  - 7788105
ER  - 

TY  - JOUR
AB  - Since the 1st case officially confirmed on the last March 2020, Indonesia recorded more than 1000 new cases daily. The national trend shows no sign of decrease as 19 September 2020 the report sets a new mark of 4000 new cases in a day. The concept of controlling disease transmission relies on contacts suppression; and on the longer end, relies on vaccinations. As 27 September 2020, no vaccine is approved for use in the general population. Until then, countries should implement early, widespread, and strict disease mitigation strategies. While much remains to be learned on COVID-19, global evidence assert at least three strategies at the population level contributes to flatten the curve: mobility restriction, testing and isolation and rigorous contact-tracing.Indonesia is not on entire absences of actions, but the epidemic calls for more. The central government called for social distancing two weeks after the first case confirmed and regulation on the large scale social distancing (Pembatasan Sosial Berskala Besar/ PSBB) that restrict non-essential population mobility is enacted by April 2020. Recent evidence outlines test, tracing and isolation are effective in suppressing COVID-19 transmission. Minimizing testing and tracing delay, less than four days with coverage of 80% close contacts could prevent and reduce onwards transmission.That we need to more is indisputable. The vaccine is not a magic bullet; it is a long-term control measure and should be a complete series of careful and precise examinations. Indonesia will also likely require high coverage of vaccination to achieve herd immunity. At present, if there is no significant improvement in the coverage of preventive measures in the population and disease surveillance system, our hospital will be overwhelmed, and case fatality will be devastating.
AD  - 1. Faculty of Public Health, Universitas Indonesia, Depok, Indonesia. 2. Reconstra Utama Integra, Jakarta, Indonesia. iariawan@ui.ac.id.
AN  - 33020329
AU  - Ariawan, I.
AU  - Jusril, H.
C1  - 10/6/2020
DA  - Jul
DB  - PubMed
DP  - NLM
ET  - 2020/10/07
IS  - 3
J2  - Acta medica Indonesiana
KW  - Covid-19
Indonesia
health system
mobility restriction
test
tracing
treatment
LA  - eng
N1  - Ariawan, Iwan
Jusril, Hafizah
Journal Article
Indonesia
Acta Med Indones. 2020 Jul;52(3):193-195.
PY  - 2020
SN  - 0125-9326 (Print)
0125-9326
SP  - 193-195
ST  - COVID-19 in Indonesia: Where Are We?
T2  - Acta medica Indonesiana
TI  - COVID-19 in Indonesia: Where Are We?
VL  - 52
ID  - 7785039
ER  - 

TY  - JOUR
AB  - The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. No specific therapeutic agents or vaccines for COVID-19 are available, though several antiviral drugs, are under investigation as treatment agents for COVID-19. The use of convalescent plasma transfusion that contain neutralizing antibodies for COVID-19 has become the major focus. This requires mass screening of populations for these antibodies. While several countries started reporting population based antibody rate, its simple point estimate may be misinterpreted without proper estimation of standard error and confidence intervals. In this paper, we review the importance of antibody studies and present the 95% confidence intervals COVID-19 antibody rate for the Korean population using two recently performed antibody tests in Korea. Due to the sparsity of data, the estimation of confidence interval is a big challenge. Thus, we consider several confidence intervals using Asymptotic, Exact and Bayesian estimation methods. In this article, we found that the Wald method gives the narrowest interval among all Asymptotic methods whereas mid p-value gives the narrowest among all Exact methods and Jeffrey's method gives the narrowest from Bayesian method. The most conservative 95% confidence interval estimation shows that as of 00:00 on September 15, 2020, at least 32,602 people were infected but not confirmed in Korea.
AD  - Interdisplinary Program in Bioinformatics, Department of Statistics, Seoul National University, Seoul 08826, Korea.
Department of Statistics, Seoul National University, Seoul 08826, Korea.
AN  - 33017875
AU  - Apio, C.
AU  - Kamruzzaman, M.
AU  - Park, T.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.5808/GI.2020.18.3.e31
DP  - NLM
ET  - 2020/10/06
IS  - 3
J2  - Genomics & informatics
KW  - Covid-19
antibody
confidence interval
retention rate
LA  - eng
N1  - Apio, Catherine
Kamruzzaman, Md
Park, Taesung
Journal Article
Korea (South)
Genomics Inform. 2020 Sep;18(3):e31. doi: 10.5808/GI.2020.18.3.e31. Epub 2020 Sep 23.
PY  - 2020
SN  - 1598-866X (Print)
1598-866x
SP  - e31
ST  - Confidence intervals for the COVID-19 neutralizing antibody retention rate in the Korean population
T2  - Genomics & informatics
TI  - Confidence intervals for the COVID-19 neutralizing antibody retention rate in the Korean population
VL  - 18
ID  - 7785112
ER  - 

TY  - JOUR
AB  - PurposeBecause of the outbreak of Covid 19, the entire world is thinking of new strategies, preventive measures to safeguard the human life from the widespread of the pandemic. The areas where people are affected are marked as containment zones and people are not allowed to exit out of those areas. Similarly, new people are not allowed to enter inside those areas. Hence, the purpose of this paper is to propose a methodology to track the Covid zones, to enhance and tighten the security measures. A geo-fence is created for the containment zone. The person who enters or exits out of that particular zone will be monitored and alert message will be sent to that person’s mobile.Design/methodology/approachAfter tracking the location of a suspicious individual, the geo-fenced layer is mapped in the area and then the virtual perimeter is used for further trapping process. This geo-fenced layer can be viewed by the citizens as soon as it is updated by the Covid monitoring team. The geo-fencing is a concept of building a virtual perimeter area. This virtual perimeter monitoring system helps in monitoring the containment zones effectively. It reduces operational costs by using an automated system based on wireless infrastructure. It also alerts the authorities immediately to catch the violators. Thus, it helps to speed up the process of inspecting the containment zones and monitoring the individuals who violate the rules given by government.FindingsThe proposed methodologies will be an effective way to track the Covid’s communal spread. But the workflow of the system demands the required data sets and permission in legal manner to set up the environment that maintains the constitutional law and order in practice. The application developed was a prototype to display how it works if the required data sets are provided by the government. There are several tracking models that are released across the world such as Aarogya setu (India), Trace together (Singapore) and Hagmen (Israel). All these models are based on Bluetooth proximity identification; though Bluetooth proximity identification is helpful for high range in a short distance, the privacy concern is debatable one. Using modern technology, it is so easy to crack the individual gadgets and with Bluetooth enabling it makes things even worse. Thus, it is important to maintain the tracking a safer and secure one, and another issue with those Bluetooth-based applications is that tracking can be done only if the user enabled the Bluetooth option, if not the entire functioning would become a mess. The proposed methodology of tracking without Bluetooth will ensure data security also.Originality/valueThis was developed as a project by our third-year students of the Department of Information Technology of our college.
AN  - 2448231495
AU  - Anto Arockia Rosaline, R.
AU  - Lalitha, R.
AU  - Hariharan, G.
AU  - Lokesh, N.
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - ProQuest Central
DO  - http://dx.doi.org/10.1108/IJPCC-06-2020-0057
DP  - ProQuest Central
IS  - 5
KW  - Computers
Geo-fencing
Covid
Mobile network
Pandemic
Monitor
Alert
Global positioning systems--GPS
Embedded systems
Methodology
Location based services
Security
Pandemics
Workflow
Geofences
Containment
Algorithms
Automation
Tracking
Fences
Bluetooth
Data sets
COVID-19
LA  - English
N1  - Copyright - © Emerald Publishing Limited 2020
PY  - 2020
SN  - 17427371
SP  - 409-417
ST  - Tracking the Covid zones through geo-fencing technique
T2  - International Journal of Pervasive Computing and Communications
TI  - Tracking the Covid zones through geo-fencing technique
UR  - https://www.proquest.com/docview/2448231495?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahightechjournals&atitle=Tracking+the+Covid+zones+through+geo-fencing+technique&title=International+Journal+of+Pervasive+Computing+and+Communications&issn=17427371&date=2020-01-01&volume=16&issue=5&spage=409&au=Anto+Arockia+Rosaline+R%3BLalitha%2C+R%3BHariharan%2C+G%3BLokesh%2C+N&isbn=&jtitle=International+Journal+of+Pervasive+Computing+and+Communications&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1108%2FIJPCC-06-2020-0057
VL  - 16
ID  - 7784954
ER  - 

TY  - JOUR
AB  - California Gov Gavin Newsom on Sept 25 signed into law a package of mental health?related bills that puts California at the forefront of efforts by states to address a mental health crisis that has been worsening for years and is being amplified by the COVID-19 pandemic, the Steinberg Institute reported The new laws will make it easier for Californians to get mental health treatment covered by their private health insurer, will expand the mental health workforce by making greater use of peer support specialists and will facilitate the ability of counties to get severely mentally ill people into outpatient treatment The bill also will require insurers, when making level-of-care determinations, to use objective criteria spelled out in the federal court ruling in Wit v United Behavioral Health, the landmark case that found the insurer used flawed criteria it developed in-house to justify denials of care (see MHW, Sept 11) Among the bills is AB 1976, which amends the bill known as Laura&#039;s Law, making it permanent and requiring all counties to implement the program, unless they formally opt out of doing so
AU  - Anonymous
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - California governor signs historic package of MH bills
T2  - Mental Health Weekly
TI  - California governor signs historic package of MH bills
UR  - https://doi.org/10.1002/mhw.32532
ID  - 7788152
ER  - 

TY  - JOUR
AB  - Caron Treatment Centers is an in-network provider for Aetna, effective Oct 1, the Pennsylvania-based program announced last week ?The COVID-19 pandemic is taking a toll on the mental health of Americans,? said Doug Tieman, CEO and President of Caron Treatment Centers ?Unfortunately, isolation and anxiety make addiction worse, and we are already seeing a spike in substance use and substance use disorders It&#039;s imperative that families have access to affordable, high-quality, life-saving treatment programs and support services ? The expansion of in-network insurance relationships is among several recent moves by Caron to make treatment more accessible Caron is also an in-network provider with Highmark and the Blue Card program, which covers persons entitled to benefits as a member of any other Blue Cross and/or Blue Shield plan licensed by the Blue Cross Blue Shield Association, Independence Blue Cross, AmeriHealth Administrators, Independence Administrators, UPMC, Blue Cross Blue Shield, Employer Groups of Penn Medicine and Tower Health ?Accessing quality substance use disorder treatment has always been difficult for many families,? continued Tieman ?With more than 20 percent of the treatment sector reducing or closing services and programs as a result of the pandemic, it&#039;s even more difficult This in-network agreement with Aetna allows their members to access Caron at a time when they are needed the most ?
AU  - Anonymous
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Caron in-network with Aetna
T2  - Alcoholism & Drug Abuse Weekly
TI  - Caron in-network with Aetna
UR  - https://doi.org/10.1002/adaw.32852
ID  - 7788125
ER  - 

TY  - JOUR
AU  - Anonymous
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Can you speed up managing a pandemic?
T2  - Prescriber
TI  - Can you speed up managing a pandemic?
UR  - https://doi.org/10.1002/psb.1861
ID  - 7788103
ER  - 

TY  - JOUR
AN  - 2007901506
AU  - Anonymous
C1  - 10/6/2020
DA  - October
DB  - Embase
DO  - http://dx.doi.org/10.1016/j.recesp.2020.06.021
DP  - Ovid Technologies
IS  - 10
KW  - article
coronavirus disease 2019
human
language
LA  - Spanish
PY  - 2020
SN  - 0300-8932
1579-2242
SP  - 790-791
ST  - COVID-19 and medical language. [Spanish]
T2  - Revista Espanola de Cardiologia
TI  - COVID-19 and medical language. [Spanish]
TT  - La covid-19 y el lenguaje medico.
UR  - http://www.elsevier.com/journals/revista-espanola-de-cardiologia/0300-8932
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007901506
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1016%2Fj.recesp.2020.06.021&issn=0300-8932&isbn=&volume=73&issue=10&spage=790&pages=790-791&date=2020&title=Revista+Espanola+de+Cardiologia&atitle=La+covid-19+y+el+lenguaje+medico&aulast=&pid=%3Cauthor%3Eanonymous%3C%2Fauthor%3E&%3CAN%3E2007901506%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 73
ID  - 7782843
ER  - 

TY  - JOUR
AD  - Department of Rheumatology, Vanderbilt University, Nashville, TN, USA.
Department of Neurology, University of Arkansas for Medical Sciences, 4301 W. Markham St #500, Little Rock, AR, 72205-7199, USA. KNalleballe@uams.edu.
Department of Neurology, University of Arkansas for Medical Sciences, 4301 W. Markham St #500, Little Rock, AR, 72205-7199, USA.
Department of Internal Medicine, Baptist-Health, North Little Rock, AR, USA.
Department of Rheumatology, UConn Health Center, Farmington, CT, USA.
AN  - 33011932
AU  - Annapureddy, N.
AU  - Nalleballe, K.
AU  - Onteddu, S. R.
AU  - Sharma, R.
AU  - Sheng, S.
AU  - Kovvuru, S.
AU  - Siddamreddy, S.
AU  - Mandhadi, R.
C1  - 10/6/2020
C2  - PMC7532946
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s10067-020-05439-z
DP  - NLM
ET  - 2020/10/05
J2  - Clinical rheumatology
LA  - eng
N1  - 1434-9949
Annapureddy, Narender
Nalleballe, Krishna
Orcid: 0000-0003-4943-171x
Onteddu, Sanjeeva Reddy
Sharma, Rohan
Sheng, Sen
Kovvuru, Sukanthi
Siddamreddy, Suman
Mandhadi, Ranadeep
Letter
Clin Rheumatol. 2020 Oct 4:1-3. doi: 10.1007/s10067-020-05439-z.
PY  - 2020
SN  - 0770-3198 (Print)
0770-3198
SP  - 1-3
ST  - Biologics in systemic autoimmune diseases during COVID-19 pandemic
T2  - Clinical rheumatology
TI  - Biologics in systemic autoimmune diseases during COVID-19 pandemic
ID  - 7785642
ER  - 

TY  - JOUR
AU  - Ann Glynn, Mary
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - �?5 Days to slow the spread�? Covid-19 and collective resilience
T2  - Journal of Management Studies
TI  - �?5 Days to slow the spread�? Covid-19 and collective resilience
UR  - https://doi.org/10.1111/joms.12644
ID  - 7788291
ER  - 

TY  - JOUR
AB  - The debate around the COVID-19 response in Africa has mostly focused on effects and implications of public health measures, in light of the socio-economic peculiarities of the continent. However, there has been limited exploration of the impact of differences in epidemiology of key comorbidities, and related healthcare factors, on the course and parameters of the pandemic. We summarize what is known about (a) the pathophysiological processes underlying the interaction of co-infections and co-morbidities in shaping prognosis of COVID-19 patients, (b) the epidemiology of key co-infections and comorbidities, and the state of related healthcare infrastructure that might shape the course of the pandemic, and (c) implications of (a) and (b) for pandemic management and post-pandemic priorities. There is a critical need to generate empirical data on clinical profiles and the predictors of morbidity and mortality from COVID-19. Improved protocols for acute febrile illness and access to diagnostic facilities, not just for SARS-CoV-2 but also other viral infections, is of urgent importance. The role of Malaria, HIV/TB and chronic malnutrition on pandemic dynamics should be further investigated. Although chronic non-communicable diseases account for a relatively lighter burden, they have a significant effect on COVID-19 prognosis, and the fragility of care-delivery systems implies that adjustments to clinical procedures and re-organization of care delivery that have been useful in other regions are unlikely to be feasible. Africa is a large region with local variations in factors that can shape pandemic dynamics. A one-size fits all response is not optimal, but there are broad lessons relating to differences in epidemiology and healthcare delivery factors, that should be considered as part of a regional COVID-19 response framework.
AD  - Department of Microbiology (Virology Research), Lagos State University, Ojo, Lagos, Nigeria.
Population Health Science Program & Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA.
Africa Health Research Institute, Durban, South Africa.
School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Department of Medicine, Division of Nephrology, Upstate Medical University, NY, USA.
Department of Biochemistry, Lagos State University, Ojo, Lagos, Nigeria.
CPT US Army Reserve, City, USA.
Bayou City Physicians, City, USA.
Department of Microbiology and Immunology, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Nursing Department, University of Texas at Arlington, USA.
Department of Internal Medicine, Brookdale University Hospital Medical Centre, USA.
Department of Infectious Diseases, Medical College of Georgia, Augusta University, USA.
Independent Researcher, Seattle Washington, USA.
Centre for Global Health and Division of Pediatric Global Health, Massachusetts General Hospital, Boston, USA.
Department of Pediatrics, Harvard Medical School, Boston, USA.
AN  - 33012053
AU  - Anjorin, A. A.
AU  - Abioye, A. I.
AU  - Asowata, O. E.
AU  - Soipe, A.
AU  - Kazeem, M. I.
AU  - Adesanya, I. O.
AU  - Raji, M. A.
AU  - Adesanya, M.
AU  - Oke, F. A.
AU  - Lawal, F. J.
AU  - Kasali, B. A.
AU  - Omotayo, M. O.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1111/tmi.13504
DP  - NLM
ET  - 2020/10/05
J2  - Tropical medicine & international health : TM & IH
KW  - Africa
Covid-19
Co-infections
Co-morbidities
SARS-CoV-2
pandemic
LA  - eng
N1  - 1365-3156
Anjorin, A A
Abioye, A I
Asowata, O E
Soipe, A
Kazeem, M I
Adesanya, I O
Raji, M A
Adesanya, M
Oke, F A
Lawal, F J
Kasali, B A
Omotayo, M O
Journal Article
England
Trop Med Int Health. 2020 Oct 4. doi: 10.1111/tmi.13504.
PY  - 2020
SN  - 1360-2276
ST  - Comorbidities and the COVID-19 Pandemic Dynamics in Africa
T2  - Tropical medicine & international health : TM & IH
TI  - Comorbidities and the COVID-19 Pandemic Dynamics in Africa
ID  - 7785628
ER  - 

TY  - JOUR
AD  - Australian National University Medical School, Canberra Hospital, ACT, Australia.
AN  - 33016773
AU  - Anderson, K.
AU  - Looi, J. C.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1177/1039856220960380
DP  - NLM
ET  - 2020/10/06
J2  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
KW  - Zoom
medical education
mental disorder
overuse
video-meeting
LA  - eng
N1  - 1440-1665
Anderson, Katrina
Looi, Jeffrey Cl
Orcid: 0000-0003-3351-6911
Journal Article
England
Australas Psychiatry. 2020 Oct 5:1039856220960380. doi: 10.1177/1039856220960380.
PY  - 2020
SN  - 1039-8562
SP  - 1039856220960380
ST  - Chronic Zoom Syndrome: emergence of an insidious and debilitating mental health disorder during COVID-19
T2  - Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists
TI  - Chronic Zoom Syndrome: emergence of an insidious and debilitating mental health disorder during COVID-19
ID  - 7785181
ER  - 

TY  - JOUR
AU  - Ancona, Deborah
AU  - Bresman, Henrik
AU  - Mortensen, Mark
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Shifting Team Research after COVID-19:Evolutionary and Revolutionary Change
T2  - Journal of Management Studies
TI  - Shifting Team Research after COVID-19:Evolutionary and Revolutionary Change
UR  - https://doi.org/10.1111/joms.12651
ID  - 7788296
ER  - 

TY  - JOUR
AB  - COVID 19 is a contagious viral disease caused via SARS CoV 2 appeared at Wuhan,the chinese city, which has spread worldwide. SARSCoV-2 has been shown to be relatively associated with bat {SARS-like} viruses, and therefore bats may be a potential reservoir of infection. origin and transmission for humans is unknown, but rapid transmission from humans to humans has been confirmed widely. O glycosylation plays a major role in causing coronavirus infection, which creates an antigenic structure,virus can not survive outside its host and by default uses cells of the host. Host cell adhesion to the virus occurs mainly independently of blood type ABO via a genetically unspecified evolutionary structure, and appears to act as a pathogen host pathway functional for many contagious diseases. however, while susceptibility and severity depend on several factors such as individuals of A blood type who unable to respond to acquired or inherent antibodies for synthesize hybrid ((A-like)) formations due to the selection of clonal and plasma protein adaptation Thus individuals with a blood group A will be a preferred target of the virus that uses glycotransferase to phenotype, and leads to more hybrid correlation of the blood type A-allelic type of hybrid while associated O individuals with the lowest risk to be infected. © 2020, Advanced Scientific Research. All rights reserved.
AD  - Education in karbala, Iraq
AU  - Alzamily, I. A.
AU  - Fadhil, A. K.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.31838/ijpr/2020.12.02.353
IS  - 2
J2  - Int. J. Pharm. Res.
KW  - A antigen
ABO system
ACE2
Blood group O
SARS CoV 2
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
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N., Pre-fusion structure of a human coronavirus spike protein (2016) Nature, 531, pp. 118-121; Walls, A. C., Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy (2016) Nat. Struct. Mol. Biol, 23, pp. 899-905; Walls, A. C., Unexpected receptor functional mimicry elucidates activation of coronavirus fusion (2019) Cell, 176, pp. 1026-1. , 39.e5; Shang, J., Ye, G., Shi, K., Wan, Y., Luo, C., Aihara, H., Geng, Q., Li, F., Structural basis of receptor recognition by SARSCoV-2 (2020) Nature, , Mar 30; Lan, J., Ge, J., Yu, J., Shan, S., Zhou, H., Fan, S., Zhang, Q., Wang, X., Structure of the SARS-CoV-2 spike receptorbinding domain bound to the ACE2 receptor (2020) Nature, , Mar 30; Wang, Q., Zhang, Y., Wu, L., Niu, S., Song, C., Zhang, Z., Lu, G., Qi, J., Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2 (2020) Cell, , Apr 7. pii: S0092-8674(20)30338-X; Letko, M., Marzi, A., Munster, V., Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses (2020) Nat Microbiol, , Feb 24; Smart, E., Armstrong, B., Blood group systems (2008) Journal compilation Blackwell Publishing Ltd. ISBT Science Series, 3, pp. 68-92; Guillon, P., Clement, M., Sebille, V., Rivain, J-G., Chou, C-F., RuvoenClouet, N., Le Pendu, J., Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies (2008) Glycobiology, 18, pp. 1085-1093; Zhao, J., Yang, Y., Huang, H., Relationship between the ABO Blood Group and the COVID-19 Susceptibility (2020), medRxiv 2020.03.11.20031096; Hoffmann, M., Kleine-Weber, H., Krüger, N., The novel coronavirus 2019 (2019nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells (2020) bioRxiv, , 2020.01.31.929042; Arend, P., Position of human blood group O(H) and phenotype-determining enzymes in growth and infectious disease (2018) Annals of the New York Academy of Sciences, 1425, pp. 5-18; Neil, SJ., McKnight, A., Gustafsson, K., Weiss, RA., HIV-1 incorporates ABO histo-blood group antigens that sensitize virions to complement-mediated inactivation (2005) Blood, 105, pp. 4693-4699; Durrbach, A., Baple, E., Preece, AF., Charpentier, B., Gustafsson, K., Virus �trecognition by specific natural antibodies and complement results in MHC I cross-presentation (2007) Eur J Immunol, 37, pp. 1254-1265; Anderson, RM., Fraser, C., Ghani, AC., Donnelly, CA., Riley, S., Fergusson, NM., Leung, GM., Hedley, AJ., Epidemiology, transmission dynamics and control of SARS: The 2002�?003 epidemic (2004) Phil Trans R Soc Lond B, 359, pp. 1091-1105; Marionneau, S., Cailleau-Thomas, A., Rocher, J., Le Moullac-Vaidye, B., Ruvoen-clouet, N., Clement, M., Le Pendu, J., ABH and Lewis histo-blood group antigens, a model for the meaning of oligosaccharide diversity in the face of a changing world Biochimie, 83, pp. 565-573. , (1002); Van Der Hoek, L., Human coronaviruses: What do they cause? (2005) AntivirTher, 12, pp. 651-658
PY  - 2020
SN  - 09752366 (ISSN)
SP  - 2623-2628
ST  - Susceptibility of abo system for infection of COVID-19
T2  - International Journal of Pharmaceutical Research
TI  - Susceptibility of abo system for infection of COVID-19
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091724116&doi=10.31838%2fijpr%2f2020.12.02.353&partnerID=40&md5=0e171b02a2f222b3b9e1c323814970cf
VL  - 12
ID  - 7783220
ER  - 

TY  - JOUR
AB  - BACKGROUND The characteristics of COVID-19 outbreak and high fatality rate of COVID-19 infection have attracted the attention of scientists due to the strong interactions between components of metabolic syndrome, metabolic abnormalities, and viral pathobiology of COVID-19. Combined metabolic cofactors supplementation (CMCS) consisting of L-serine, N-acetyl-L-cysteine (NAC), nicotinamide riboside (NR), and L-carnitine tartrate is being studied for the treatment of patients with COVID-19. METHODS We conducted a placebo-controlled, phase-2 clinical trial involving ambulatory COVID-19 patients. A total of 100 patients were randomly assigned on a 3:1 basis to hydroxychloroquine plus CMCS or hydroxychloroquine plus placebo. The total treatment period for the hydroxychloroquine was 5 days, and for the CMCS/placebo was 14 days. Clinical status was evaluated daily by phone, using a binomial scale for subject reported presence or absence for multiple COVID-19 related symptoms. Plasma samples for clinical chemistry analyses were collected on day 0 and day 14. RESULTS A total of 93 patients completed the trial. The combination of CMCS and hydroxychloroquine significantly reduced the average complete recovery time compared with hydroxychloroquine and placebo (6.6 days vs 9.3 days, respectively). Moreover, there was a significant reduction in ALT, AST and LDH levels on day 14 compared to day 0 in the hydroxychloroquine plus CMCS group. The adverse effects were uncommon and self-limiting. CONCLUSIONS In patients with mild-to-moderate COVID-19, CMCS resulted in a significant reduction in recovery time and liver enzymes associated with hepatic function compared to placebo. We observed that CMSC is associated with a low incidence of adverse events.Competing Interest StatementAM, JB and MU filed a patent application on the use of CMCS on COVID-19 patients. The other authors declare no competing interests.Clinical TrialClinicalTrials.gov NCT04573153Funding StatementThis work was supported by Knut and Alice Wallenberg Foundation. The authors would like to thank ChromaDex (Irvine, CA, USA) for providing NR for this study.Author DeclarationsI confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.YesThe details of the IRB/oversight body that provided approval or exemption for the research described are given below:This study has been approved by the ethics committee of Istanbul Medipol University. Decision No:45 Decision Date: 28/05/2020 Members of Ethics Committee: Professor Hanefi OZBEK Professor Gurkan OZTURK Professor Fulya IlCin GONENC Professor Abdulbari BENER Associate Professor Ali OZTURK Associate Professor Bahri TEKER Associate Professor Muhammed Fatih EVCIMIK All necessary patient/participant consent has been obtained and the appropriate institutional forms have been archived.YesI understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov. I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance).Yes I have followed all appropriate research reporting guidelines and uploaded the relevant EQUATOR Network research reporting checklist(s) and other pertinent material as supplementary files, if applicable.YesThe data that support the findings of this study are available from the corresponding author [adilm@scilifelab.se], upon reasonable request.
AU  - Altay, Ozlem
AU  - Yang, Hong
AU  - Aydin, Mehtap
AU  - Alkurt, Gizem
AU  - Altunal, Nilsun
AU  - Kim, Woonghee
AU  - Akyol, Dogukan
AU  - Arif, Muhammed
AU  - Zhang, Cheng
AU  - Dinler-Doganay, Gizem
AU  - Turkez, Hasan
AU  - Shoaie, Saeed
AU  - Nielsen, Jens
AU  - Boren, J. A. N.
AU  - Doganay, Levent
AU  - Uhlen, Mathias
AU  - Mardinoglu, Adil
C1  - 10/6/2020
DB  - medRxiv
DO  - 10.1101/2020.10.02.20202614
DP  - medRxiv
PY  - 2020
SP  - 2020.10.02.20202614
ST  - Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 (preprint)
T2  - medRxiv
TI  - Combined metabolic cofactor supplementation accelerates recovery in mild-to-moderate COVID-19 (preprint)
UR  - http://medrxiv.org/content/early/2020/10/05/2020.10.02.20202614.abstract
ID  - 7788871
ER  - 

TY  - JOUR
AB  - Objective: to determine the level of blood markers of cellular Human Cluster of Differentiation 147 (CD147) by ELISA assay. Immunological system, establishing the profile in patientsSARS-CoV-2 invades host cells via a novel route: CD147-spike protein. Methods: a case-control study including 30 patients (10 female) with SARS-CoV-2 repertory disorder whose follow-up was carried out at the outpatient clinic of the intensive care unit Service at Al Hussain Hospital, southern of Iraq, Patients were divided into three subgroups based on the onset of symptoms within the first 6 days of the acute phase of disease: subgroup A, subgroup B, and C. according to the type of drugs. Main systemic subgroup. Treatment group included 60 outpatients (25 female) being submitted to follow-up at the same hospital for non-inflammatory diseases. For determined the plasmatic levels of Human Cluster of Differentiation 147 (CD147), groups of S proteins Results: To start with, in vitro antiviral tests showed Meplazumab, infliximab and Etrolizumab an foe of CD147 adapted neutralizer, essentially hindered the infections from attacking host cells in comparison to controls, patients with presented concentrations of CD147 products (determined by plasmatic levels of S protein circulating in blood. Conclusion: our results indicate the presence of molecular SARS-CoV-2 invades respiratory cells determined by assay in patients which confirm a decrease in the defense capacity of the cellular system against toxicity induced by drugs in these patients. © 2020, Advanced Scientific Research. All rights reserved.
AD  - Department of Biology. Faculty of Science and Mathematics, University Pendidkan Sultan idris, Malaysia
Faculty of Veterinary Medical, University Putra Malaysia, Malaysia
Department of Chemistry. Faculty of Science and Mathematics, University Pendidkan Sultan idris, Malaysia
Chemistry Dept. faculty pharmaceutical, ThiQar University, Iraq
Ministry of Education, Directorate of Education Thi-Qar, Iraq
College of Health and Medical Technology, Al-Ayen University, Iraq
AU  - Al-Salih, M.
AU  - Samsudin, S.
AU  - Alsalih, S. W.
AU  - Arshad, S. S.
AU  - Warid, F.
AU  - Sfoog, A. A.
AU  - Abed, R. E.
AU  - Roomi, A. B.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.31838/ijpr/2020.12.02.359
IS  - 2
J2  - Int. J. Pharm. Res.
KW  - CD147
COVID19
Human Cluster of Differentiation
SARS-CoV-2
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Al-Salih, M.; Department of Biology. Faculty of Science and Mathematics, University Pendidkan Sultan idrisMalaysia; email: moatasemalsalih@gmail.com
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S., Raadsen, M. P., Grifoni, A., Okba, N. M. A., Endeman, H., Akker, J. P. C., Vries, R. D., Phenotype of SARS-CoV-2-specific T-cells in COVID-19 patients with acute respiratory distress syndrome (2020), https://doi.org/10.1101/2020.04.11.20062349, van den, van, de de. MedRxiv, April, 2020.04.11.20062349; Yang, J., Zheng, Y., Gou, X., Pu, K., Chen, Z., Guo, Q., Ji, R., Zhou, Y., Prevalence of comorbidities and its effects in coronavirus disease 2019 patients: A systematic review and meta-analysis (2020) International Journal of Infectious Diseases, 94, pp. 91-95. , https://doi.org/10.1016/j.ijid.2020.03.017; Yen, M. Y., Schwartz, J., Chen, S. Y., King, C. C., Yang, G. Y., Hsueh, P. R., Interrupting COVID-19 transmission by implementing enhanced traffic control bundling: Implications for global prevention and control efforts (2020) Journal of Microbiology, Immunology and Infection, , https://doi.org/10.1016/j.jmii.2020.03.011, xxxx, 0; Yoshimura, N., Yokoyama, Y., Sako, M., Aoyama, N., Hirai, F., Sawada, K., Kashiwagi, N., Suzuki, Y., Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease (2019) Cytokine, 120 (January), pp. 54-61. , https://doi.org/10.1016/j.cyto.2019.02.014; Yurchenko, V., (2005) Dealing with the family: CD 147 interactions with cyclophilins, pp. 301-309. , https://doi.org/10.1111/j.1365-2567.2005.02316.x; Zhang, Y., Xu, J., Li, H., Cao, B., A Novel Coronavirus (COVID-19) Outbreak: A Call for Action (2020) Chest, 157 (4), pp. e99-e101. , https://doi.org/10.1016/j.chest.2020.02.014; Zhang, Y., Xu, J., Li, H., Cao, B., A Novel Coronavirus (COVID-19) Outbreak: A Call for Action (2020) Chest, 157 (4), pp. e99-e101. , https://doi.org/10.1016/j.chest.2020.02.014; Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Cao, B., Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study (2020) The Lancet, 395 (10229), pp. 1054-1062. , https://doi.org/10.1016/S0140-6736(20)30566-3
PY  - 2020
SN  - 09752366 (ISSN)
SP  - 2654-2667
ST  - Identify human cluster of differentiation 147 (CD147), a new target of SARS-CoV-2 invasion
T2  - International Journal of Pharmaceutical Research
TI  - Identify human cluster of differentiation 147 (CD147), a new target of SARS-CoV-2 invasion
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091720871&doi=10.31838%2fijpr%2f2020.12.02.359&partnerID=40&md5=3af6635b4b1a3ef4f0029302f9f7c54f
VL  - 12
ID  - 7783221
ER  - 

TY  - JOUR
AU  - Alperovitch, Annick
AU  - Lazar, Philippe
C1  - 10/6/2020
DA  - 2020/05
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 4
KW  - Clinical Trials as Topic/ethics
Ethics, Medical
Clinical Trials as Topic/legislation &amp
amp
jurisprudence
Coronavirus Infections/epidemiology
Coronavirus Infections/therapy
Emergency Medical Services/ethics
Emergency Medical Services/history
Emergency Medical Services/legislation &amp
amp
jurisprudence
Emergency Medical Services/methods
History, 21st Century
Humans
Informed Consent/ethics
Informed Consent/legislation &amp
amp
jurisprudence
Informed Consent/standards
Knowledge
Legislation, Medical
Pandemics
Pneumonia, Viral/epidemiology
Pneumonia, Viral/therapy
Quality Improvement
Quality of Health Care/ethics
Quality of Health Care/legislation &amp
amp
jurisprudence
Research Design/legislation &amp
amp
jurisprudence
Research Design/standards
Therapies, Investigational/ethics
Therapies, Investigational/standards
LA  - fr
PY  - 2020
SP  - 303-307
ST  - L'éthique des essais thérapeutiques
T2  - Med Sci (Paris)
TI  - L'éthique des essais thérapeutiques
TT  - [Ethics of clinical trials].
UR  - https://dx.doi.org/10.1051/medsci/2020092
VL  - 36
ID  - 7788588
ER  - 

TY  - JOUR
AB  - Luego de que la Organizaci�Qn Mundial de la Salud (OMS) declarara la pandemia por el nuevo coronavirus (COVID-19), se implementaron medidas a nivel mundial con el objetivo de contener su progresi�Qn. El 20 de marzo de 2020 se inici�Q el confinamiento preventivo obligatorio en Argentina. Estudios realizados en el marco de esta pandemia en China, han evidenciado consecuencias psicol�Qgicas como resultado del temor al contagio y de las medidas de aislamiento. El objetivo del presente estudio es explorar a través de una encuesta autoadministrada por v�Ta electr�Qnica, actitudes y temores frente al COVID-19, la presencia de sintomatolog�Ta depresiva y el patr�Qn de consumo de alcohol de la poblaci�Qn argentina durante el confinamiento (n = 759). Como resultado, observamos que el temor al COVID-19 fue mayor en las personas de entre 55 y 59 años, con un descenso abrupto en los mayores de 70; que el ֙nimo depresivo y el incremento en el consumo de alcohol fueron m֙s frecuentes en los m֙s j�Qvenes y que el estado de ֙nimo depresivo mostr�Q una frecuencia mayor en quienes perdieron el empleo durante el confinamiento. Finalmente, observamos que el grado de acuerdo de los participantes con la medida de confinamiento fue superior al 90% incluso en aquellas personas que sufrieron una disminuci�Qn de sus ingresos mayor al 80% durante la cuarentena. Los resultados de este estudio brindan informaci�Qn sobre grupos de riesgo para el desarrollo de s�Tntomas psicopatol�Qgicos. Estos resultados constituyen una base necesaria para el diseño de estrategias preventivas y terapéuticas focalizadas.
AU  - Alomo, Mart�Tn
AU  - Gagliardi, Georgina
AU  - Peloche, Sebastian
AU  - Somers, Eugenia
AU  - Alzina, Pilar
AU  - Prokopez, Cintia R.
C1  - 10/6/2020
DA  - 2020/09
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
IS  - 3
LA  - es
PY  - 2020
SP  - 176-181
ST  - Efectos psicol�Qgicos de la pandemia COVID-19 en la poblaci�Qn general de Argentina
T2  - Rev Fac Cien Med Univ Nac Cordoba
TI  - Efectos psicol�Qgicos de la pandemia COVID-19 en la poblaci�Qn general de Argentina
UR  - https://dx.doi.org/10.31053/1853.0605.v77.n3.28561
VL  - 77
ID  - 7788813
ER  - 

TY  - JOUR
AD  - (Al-Mandhari) World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt
A. Al-Mandhari, World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt
AN  - 2005150835
AU  - Al-Mandhari, A.
C1  - 10/6/2020
DA  - September
DB  - Embase
DO  - http://dx.doi.org/10.26719/2020.26.9.992
DP  - Ovid Technologies
IS  - 9
KW  - coronavirus disease 2019
editorial
human
LA  - English
M3  - Editorial
PY  - 2020
SN  - 1020-3397
SP  - 992-993
ST  - Coming together in the region to tackle COVID-19
T2  - Eastern Mediterranean Health Journal
TI  - Coming together in the region to tackle COVID-19
UR  - https://applications.emro.who.int/emhj/v26/09/1020-3397-2020-2609-992-993-eng.pdf?ua=1
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2005150835
VL  - 26
ID  - 7782985
ER  - 

TY  - JOUR
AD  - Department of Emergency Medicine, Santa Croce and Carle Hospital, Cuneo, Italy.
School of Emergency Medicine, University of Turin, Turin, Italy.
AN  - 33014223
AU  - Allione, A.
AU  - Giamello, J. D.
AU  - Bernardi, S.
AU  - Paglietta, G.
AU  - Cavalot, G. L. M.
AU  - Dutto, L. A.
AU  - Caruso, D.
AU  - Tortore, A.
AU  - Lauria, G.
C1  - 10/6/2020
C2  - PMC7517399
DB  - PubMed
DO  - 10.5847/wjem.j.1920-8642.2020.04.009
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - World journal of emergency medicine
LA  - eng
N1  - Allione, Attilio
Giamello, Jacopo Davide
Bernardi, Sara
Paglietta, Giulia
Cavalot, Giulia Lucia Massimina
Dutto, Luca Alessio
Caruso, Daniela
Tortore, Andrea
Lauria, Giuseppe
Case Reports
World J Emerg Med. 2020;11(4):258-259. doi: 10.5847/wjem.j.1920-8642.2020.04.009.
PY  - 2020
SN  - 1920-8642 (Print)
1920-8642
SP  - 258-259
ST  - Coronavirus disease 2019 (COVID-19) and prosthetic heart valve: An additional coagulative challenge
T2  - World journal of emergency medicine
TI  - Coronavirus disease 2019 (COVID-19) and prosthetic heart valve: An additional coagulative challenge
VL  - 11
ID  - 7785413
ER  - 

TY  - JOUR
AB  - OBJECTIVE: In 2019, an infection provoked by SARS-CoV-2 virus arose in Wuhan, China. Currently, there is still no definite and efficacious therapy for SARS-CoV-2 infection. Moreover, our understanding of the physiopathology of the infection, and risk elements for severity and mortality, is incomplete. PATIENTS AND METHODS: One largely neglected element that could affect prognosis of SARS-CoV-2 infection is the vitamin status of population. The purpose of this review is to evaluate whether a vitamin insufficiency could provoke an augmented risk of SARS-CoV-2 infection or the appearance of major complications. In particular, we evaluated the presence of studies related to the state and effects of vitamin D, C, B, and A in subjects with SARS-CoV-2 disease. RESULTS: Although, actually, the interest in a possible use for vitamin supplementation in SARS-CoV-2 patients is essentially based on indirect data, we tried to examine the evidence about a favorable effect of vitamin supplementation in the therapy of the infection and its complications. CONCLUSIONS: Supplements with vitamin A, B, C, D, and E could represent an inexpensive and sufficiently safe approach, and a useful therapeutic complement. However, solid clinical research data are expected to support such claim.
AD  - Division of Hematology, Department of Human Pathology in Adulthood and Childhood "Gaetano Barresi", University of Messina, Messina, Italy. aallegra@unime.it.
AN  - 33015818
AU  - Allegra, A.
AU  - Tonacci, A.
AU  - Pioggia, G.
AU  - Musolino, C.
AU  - Gangemi, S.
C1  - 10/6/2020
DA  - Sep
DB  - PubMed
DO  - 10.26355/eurrev_202009_23064
DP  - NLM
ET  - 2020/10/06
IS  - 18
J2  - European review for medical and pharmacological sciences
LA  - eng
N1  - 2284-0729
Allegra, A
Tonacci, A
Pioggia, G
Musolino, C
Gangemi, S
Journal Article
Italy
Eur Rev Med Pharmacol Sci. 2020 Sep;24(18):9721-9738. doi: 10.26355/eurrev_202009_23064.
PY  - 2020
SN  - 1128-3602
SP  - 9721-9738
ST  - Vitamin deficiency as risk factor for SARS-CoV-2 infection: correlation with susceptibility and prognosis
T2  - European review for medical and pharmacological sciences
TI  - Vitamin deficiency as risk factor for SARS-CoV-2 infection: correlation with susceptibility and prognosis
VL  - 24
ID  - 7785247
ER  - 

TY  - JOUR
AB  - Expansion of Medicaid and establishment of the Children's Health Insurance Program (CHIP) represent a significant success story in the national effort to guarantee health insurance for children. That success is reflected in the high rates of coverage and health care access achieved for children, including those in low-income families. But significant coverage gaps remain-gaps that have been increasing since 2016 and are likely to accelerate with the coronavirus disease 2019 (COVID-19) pandemic and the associated recession. Using National Health Interview Survey data, we found that the proportion of uninsured children was 5.5 percent in 2018. Children continue to face coverage interruptions, and Latino, adolescent, and noncitizen children continue to face elevated risks of being uninsured. Although we note the benefits of a universal, federally financed, single-payer approach to coverage, we also offer two possible reform pathways that can take place within the current multipayer system, aimed at ensuring coverage, access, continuity, and comprehensiveness to move the nation closer to the goal of providing the health care that children need to reach their full potential and to reduce racial and economic inequalities.
AD  - Joan C. Alker (jca25@georgetown.edu) is a research professor at the McCourt School of Public Policy, Georgetown University, in Washington, D.C.
Genevieve M. Kenney is a codirector and senior fellow in the Health Policy Center, Urban Institute, in Washington, D.C.
Sara Rosenbaum is the Hirsh Professor and founding chair of the Department of Health Policy, Milken Institute School of Public Health, George Washington University, in Washington, D.C.
AN  - 33017236
AU  - Alker, J. C.
AU  - Kenney, G. M.
AU  - Rosenbaum, S.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1377/hlthaff.2020.00785
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Health affairs (Project Hope)
LA  - eng
N1  - 1544-5208
Alker, Joan C
Kenney, Genevieve M
Rosenbaum, Sara
Journal Article
United States
Health Aff (Millwood). 2020 Oct;39(10):1743-1751. doi: 10.1377/hlthaff.2020.00785.
PY  - 2020
SN  - 0278-2715
SP  - 1743-1751
ST  - Children's Health Insurance Coverage: Progress, Problems, And Priorities For 2021 And Beyond
T2  - Health affairs (Project Hope)
TI  - Children's Health Insurance Coverage: Progress, Problems, And Priorities For 2021 And Beyond
VL  - 39
ID  - 7785151
ER  - 

TY  - JOUR
AB  - BACKGROUND: COVID-19 has significantly impacted the health of millions of people around the world. The shortage of personal protective equipment, including N95 respirators, in hospital facilities has put frontline healthcare professionals at high risk for contracting this virus. AIM: To develop a reproducible and safe N95 respirator reprocessing method that satisfies all presented regulatory standards and can be directly implemented by hospitals using existing available equipment. METHODS: A non-toxic gravity steam reprocessing method has been developed for the reuse of N95 respirators consisting of 30 minutes of steam treatment at 121��C followed by 30 minutes of heat drying. Samples of model number 1860, 1860s, 1870+, and 9105 N95 respirators were either collected from hospitals (for microbiology testing) or purchased new (for functionality testing), with all functionality tests (i.e. filter efficiency, fit evaluation, and strap integrity) performed at the Centers for Disease Control using standard procedures established by the National Institute for Occupational Safety and Health. FINDINGS: All tested models passed the minimum filter efficiency of 95% after three cycles of gravity steam reprocessing. The 1870+ N95 respirator model is the most promising model for reprocessing based on its efficient bacterial inactivation coupled with the maintenance of all other key functional respirator properties after multiple reprocessing steps. CONCLUSIONS: The gravity steam method can effectively reprocess N95 respirators over at least 3 reprocessing cycles without negatively impacting the functionality requirements set out by regulators. Enabling the reuse of N95 respirators is a crucial tool for managing both the current pandemic and future healthcare crises.
AD  - SteriPro Canada Inc., 6580 Northwest Dr, Unit B, Mississauga, Ontario, L4V 1L5, Canada. Electronic address: anas.aljabo@steriprocanada.com.
Department of Chemical Engineering, McMaster University, 1280 Main St. W, Hamilton, Ontario, L8S 4L7, Canada.
SteriPro Canada Inc., 6580 Northwest Dr, Unit B, Mississauga, Ontario, L4V 1L5, Canada.
AN  - 33017616
AU  - Aljabo, A.
AU  - Mueller, E.
AU  - Abdul-Azeez, D.
AU  - Hoare, T.
AU  - Jain, A.
C1  - 10/6/2020
DA  - Oct 2
DB  - PubMed
DO  - 10.1016/j.jhin.2020.09.032
DP  - NLM
ET  - 2020/10/06
J2  - The Journal of hospital infection
KW  - Covid-19
Filtration
N95 respirators
Reprocessing
Reuse
Steam
which offers medical device reprocessing services to hospitals and has a financial
interest in this work. AJ has indirect equity interest in SteriPro Canada Inc. EM,
DAA, and TH have no conflict of interest in this work.
LA  - eng
N1  - 1532-2939
Aljabo, Anas
Mueller, Eva
Abdul-Azeez, Dabeer
Hoare, Todd
Jain, Arun
Journal Article
England
J Hosp Infect. 2020 Oct 2:S0195-6701(20)30457-6. doi: 10.1016/j.jhin.2020.09.032.
PY  - 2020
SN  - 0195-6701
ST  - Gravity Steam Reprocessing in Healthcare Facilities for the Reuse of N95 Respirators
T2  - Journal of hospital infection
TI  - Gravity Steam Reprocessing in Healthcare Facilities for the Reuse of N95 Respirators
ID  - 7785124
ER  - 

TY  - JOUR
AB  - While there have been very few fatal cases, SARS-CoV-2 has been reported in paediatric patients. This study aims to describe a fatal case of COVID-19 in a child with severe acute malnutrition. The eight-month-old child presented with fever, diarrhoea, and difficulty in breathing. The mother of the child had fever and shortness of breath four weeks before she died. Physical examination revealed lethargy, dehydration, and severe weight loss with a weight of 5 kg at a height of 78 cm tall. The weight-for-height index was less than three Z-scores, which corresponds to severe acute malnutrition. The pulmonary examination revealed moderate respiratory distress, and the chest X-ray presented features suggestive of pneumonia in the right lung area. In the context of the COVID-19 outbreak in Niger and the circumstances of the mother’s death, a nasal swab was taken for laboratory confirmation. Treatment provided to the child included intranasal oxygen, antibiotics, and a dietary program with therapeutic milk. The child died 48 hours after his admission. The history of contact with a SARS-CoV-2 suspect or positive patient should lead to screening for infection by using RT-PCR. It is important to investigate malnutrition as a potential risk factor for severe SARS-CoV-2 infection and resultant mortality.
AD  - Department of Pediatrics, Amirou Boubacar Diallo National Hospital of Niamey, Niamey, Niger; Sciences of Health Faculty, Abdou Moumouni University of Niamey, Niamey, Niger ; Faculty of Health Science, University of Zinder, Zinder, Niger ; Sciences of Health Faculty, Abdou Moumouni University of Niamey, Niamey, Niger ; Department of Pediatrics, Amirou Boubacar Diallo National Hospital of Niamey, Niamey, Niger ; Centre de Recherche Médicale et Sanitaire (CERMES), Niamey, Niger ; Department of Pediatrics, Amirou Boubacar Diallo National Hospital of Niamey, Niamey, Niger; Sciences of Health Faculty, Abdou Moumouni University of Niamey, Niamey, Niger
AN  - 2448259106
AU  - Alido, Soumana
AU  - Samaila, Aboubacar
AU  - Moustapha, Lamine Mahaman
AU  - Moumouni, Kamaye
AU  - Balkissa, Daouda
AU  - Ibrahim Alkassoum, Salifou
AU  - Adamou, Lagare
AU  - Eric Omar, Adehossi
AU  - Maman, Laminou Ibrahim
C1  - 10/6/2020
DA  - 2020
2020-10-05
DB  - Coronavirus Research Database; ProQuest Central
DO  - http://dx.doi.org/10.1155/2020/8847415
DP  - ProQuest Central
KW  - Medical Sciences--Pediatrics
Comorbidity
Laboratories
Infections
Vaccines
Fatalities
Pneumonia
Diarrhea
Age
Severe acute respiratory syndrome coronavirus 2
Epidemiology
Immune system
Oxygen therapy
Fever
Children & youth
Malnutrition
Coronaviruses
Case management
Pediatrics
Babies
Disease transmission
COVID-19
Niger
China
LA  - English
N1  - Copyright - Copyright © 2020 Alido Soumana et al. This is an open access article distributed under the Creative Commons Attribution License (the “License�?, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/
SubjectsTermNotLitGenreText - Niger; China
PY  - 2020
SN  - 20906803
ST  - A Fatal Case of COVID-19 in an Infant with Severe Acute Malnutrition Admitted to a Paediatric Ward in Niger
T2  - Case Reports in Pediatrics
TI  - A Fatal Case of COVID-19 in an Infant with Severe Acute Malnutrition Admitted to a Paediatric Ward in Niger
UR  - https://www.proquest.com/docview/2448259106?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Ahealthcompleteshell&atitle=A+Fatal+Case+of+COVID-19+in+an+Infant+with+Severe+Acute+Malnutrition+Admitted+to+a+Paediatric+Ward+in+Niger&title=Case+Reports+in+Pediatrics&issn=20906803&date=2020-01-01&volume=2020&issue=&spage=&au=Alido+Soumana%3BSamaila%2C+Aboubacar%3BMoustapha%2C+Lamine+Mahaman%3BMoumouni+Kamaye%3BBalkissa+Daouda%3BIbrahim+Alkassoum+Salifou%3BAdamou+Lagare%3BEric+Omar+Adehossi%3BMaman%2C+Laminou+Ibrahim&isbn=&jtitle=Case+Reports+in+Pediatrics&btitle=&rft_id=info:eric/&rft_id=info:doi/10.1155%2F2020%2F8847415
VL  - 2020
ID  - 7784944
ER  - 

TY  - JOUR
AB  - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global pandemic of coronavirus disease-2019 (COVID-19). SARS-CoV-2 is a zoonotic disease, but little is known about variations in species susceptibility that could identify potential reservoir species, animal models, and the risk to pets, wildlife, and livestock. Certain species, such as domestic cats and tigers, are susceptible to SARS-CoV-2 infection, while other species such as mice and chickens are not. Most animal species, including those in close contact with humans, have unknown susceptibility. Hence, methods to predict the infection risk of animal species are urgently needed. SARS-CoV-2 spike protein binding to angiotensin-converting enzyme 2 (ACE2) is critical for viral cell entry and infection. Here we integrate species differences in susceptibility with multiple in-depth structural analyses to identify key ACE2 amino acid positions including 30, 83, 90, 322, and 354 that distinguish susceptible from resistant species. Using differences in these residues across species, we developed a susceptibility score that predicts an elevated risk of SARS-CoV-2 infection for multiple species including horses and camels. We also demonstrate that SARS-CoV-2 is nearly optimal for binding ACE2 of humans compared to other animals, which may underlie the highly contagious transmissibility of this virus among humans. Taken together, our findings define potential ACE2 and SARS-CoV-2 residues for therapeutic targeting and identification of animal species on which to focus research and protection measures for environmental and public health.
AD  - Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center (VUMC), Nashville, TN, USA.
Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA.
Center for Structural Biology, Vanderbilt University, Nashville, TN, USA.
Department of Chemistry, Vanderbilt University, Nashville, TN, USA.
Department of Physics and Astronomy, Vanderbilt University, Nashville, TN, USA.
Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN, USA.
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA.
Department of Biological Sciences, Vanderbilt University, Nashville, TN, USA.
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Institute for Drug Discovery, Leipzig University Medical School, Leipzig, Germany.
Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN, USA.
AN  - 33015868
AU  - Alexander, M. R.
AU  - Schoeder, C. T.
AU  - Brown, J. A.
AU  - Smart, C. D.
AU  - Moth, C.
AU  - Wikswo, J. P.
AU  - Capra, J. A.
AU  - Meiler, J.
AU  - Chen, W.
AU  - Madhur, M. S.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1096/fj.202001808R
DP  - NLM
ET  - 2020/10/06
J2  - FASEB journal : official publication of the Federation of American Societies for Experimental Biology
KW  - Covid-19
angiotensin-converting enzyme 2
protein structural elements
severe acute respiratory syndrome coronavirus 2
LA  - eng
N1  - 1530-6860
Alexander, Matthew R
Schoeder, Clara T
Brown, Jacquelyn A
Smart, Charles D
Moth, Chris
Wikswo, John P
Capra, John A
Meiler, Jens
Chen, Wenbiao
Madhur, Meena S
F32HL144048-01/NH/NIH HHS/United States
DK117147/NH/NIH HHS/United States
UH3TR002097/NH/NIH HHS/United States
U01TR002383/NH/NIH HHS/United States
U19AI117905/NH/NIH HHS/United States
U01AI150739/NH/NIH HHS/United States
R01AI141661/NH/NIH HHS/United States
R35GM127087/NH/NIH HHS/United States
DP2HL137166/NH/NIH HHS/United States
20PRE35080177/American Heart Association/
EIA34480023/American Heart Association/
Journal Article
United States
FASEB J. 2020 Oct 4. doi: 10.1096/fj.202001808R.
PY  - 2020
SN  - 0892-6638
ST  - Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species
T2  - FASEB journal : official publication of Federation of American Societies for Experimental Biology
TI  - Predicting susceptibility to SARS-CoV-2 infection based on structural differences in ACE2 across species
ID  - 7785237
ER  - 

TY  - JOUR
AB  - The coronavirus disease (COVID-19) brought the world to a halt in March 2020. Various prediction and risk management approaches are being explored worldwide for decision making. This work adopts an advanced mechanistic model and utilizes tools for process safety to propose a framework for risk management for the current pandemic. A parameter tweaking and an artificial neural network-based parameter learning model have been developed for effective forecasting of the dynamic risk. Monte Carlo simulation was used to capture the randomness of the model parameters. A comparative analysis of the proposed methodologies has been carried out by using the susceptible, exposed, infected, quarantined, recovered, deceased (SEIQRD) model. A SEIQRD model was developed for four distinct locations: Italy, Germany, Ontario, and British Columbia. The learning-based approach resulted in better outcomes among the models tested in the present study. The layer of protection analysis is a useful framework to analyze the effect of different safety measures. This framework is used in this work to study the effect of non-pharmaceutical interventions on pandemic risk. The risk profiles suggest that a stage-wise releasing scenario is the most suitable approach with negligible resurgence. The case study provides valuable insights to practitioners in both the health sector and the process industries to implement advanced strategies for risk assessment and management. Both sectors can benefit from each other by using the mathematical models and the management tools used in each, and, more importantly, the lessons learned from crises.
AD  - Centre for Risk, Integrity and Safety Engineering (C-RISE) Faculty of Engineering and Applied Science Memorial University of Newfoundland, St. John's, NL, Canada.
Department of Process Engineering and Applied Science Dalhousie University, Halifax, NS, Canada.
AN  - 33013002
AU  - Alauddin, M.
AU  - Islam Khan, M. A.
AU  - Khan, F.
AU  - Imtiaz, S.
AU  - Ahmed, S.
AU  - Amyotte, P.
C1  - 10/6/2020
C2  - PMC7525359
DA  - Sep 30
DB  - PubMed
DO  - 10.1016/j.jlp.2020.104310
DP  - NLM
ET  - 2020/10/06
J2  - Journal of loss prevention in the process industries
KW  - Layers of protection
Neural network
Non-pharmaceutical interventions
Pandemic
Process monitoring
Risk
personal relationships that could have appeared to influence the work reported in
this paper.
LA  - eng
N1  - 1873-3352
Alauddin, Md
Islam Khan, Md Aminul
Khan, Faisal
Imtiaz, Syed
Ahmed, Salim
Amyotte, Paul
Journal Article
J Loss Prev Process Ind. 2020 Sep 30:104310. doi: 10.1016/j.jlp.2020.104310.
PY  - 2020
SN  - 0950-4230 (Print)
0950-4230
SP  - 104310
ST  - How can process safety and a risk management approach guide pandemic risk management?
T2  - Journal of loss prevention in process industries
TI  - How can process safety and a risk management approach guide pandemic risk management?
ID  - 7785514
ER  - 

TY  - JOUR
AB  - Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly infectious disease with a potential for healthcare workers (HCWs) getting infected due to inadequate protection while attending to patients Effective use of personal protective equipment (PPE) is key to mitigating the spread of SARS-CoV-2 infection in healthcare settings Hence, there is a need to understand HCWs&#039; use of PPE in resource-limited settings and how closely the currently recommended guidelines for PPE are followed This study assessed the HCWs&#039; knowledge about, attitudes towards, beliefs on, and use of PPE to prevent SARS-CoV-2 infection in a resource-limited setting Methods This cross-sectional study was conducted in April 2020 in Southwest and Northwest Nigeria The selection of participants was performed via the snowball sampling technique using a 33-item, web-based, self-administered questionnaire via a social media network We obtained relevant sociodemographic data and information on participants&#039; occupations and knowledge about, attitudes towards, beliefs on, and use of PPE We analysed the data using SPSS version 23 0 for Windows (IBM, Armonk, New York, USA) Apvalues Results A total of 290 subjects responded to the questionnaire, and 18 (6 2%) were excluded because of incomplete data The mean age of the respondents was 32 3 +/- 9 9 years There were 116 males (42 6%) The majority of the respondents were medical doctors (114, 41 9%), followed by nurses and clinical students Of the 272 respondents in this survey, only 70 (25 7%) had adequate knowledge about PPE Of the respondents who presumed they had adequate knowledge about donning and doffing PPE, 94 (56%) were incorrect The predictors of good knowledge were ages younger than 45 years (p=0 046) and practice location (p=0 009) Conclusion This study showed that HCWs&#039; knowledge about, attitudes towards, and beliefs on PPE and their PPE skill in practice in Nigeria were remarkably poor There is an urgent need for nationwide practical training on PPE use to curtail the spread of SARS-CoV-2 infection among HCWs
AU  - Alao, M. A.
AU  - Durodola, A. O.
AU  - Ibrahim, O. R.
AU  - Asinobi, O. A.
C1  - 10/6/2020
DA  - 2020/00
DB  - COVIDWHO
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
PY  - 2020
ST  - Assessment of Health Workers' Knowledge, Beliefs, Attitudes, and Use of Personal Protective Equipment for Prevention of COVID-19 Infection in Low-Resource Settings
T2  - Advances in Public Health
TI  - Assessment of Health Workers' Knowledge, Beliefs, Attitudes, and Use of Personal Protective Equipment for Prevention of COVID-19 Infection in Low-Resource Settings
UR  - https://doi.org/10.1155/2020/4619214
ID  - 7788319
ER  - 

TY  - JOUR
AB  - Coronavirus disease 2019 (COVID-19) is an especially deadly respiratory disease caused by a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. It was first transmitted from animal to human in November 2019 in the open seafood market in Wuhan, and then from human to human, though the exact mode of transmission is not fully defined. This virus has spread throughout the world, and no effective vaccine or cure has been developed for it up to date. In this brief overview, we review a basic knowledge for COVID-19, its associated immune, pathology and histology, as well as available therapeutic approaches to provide clarification and future medically useful targets to grasp how COVID-19 co-circulates. The infection, prevention and supportive care for COVID-19 confirmed cases are the best-proven measures for the interventions until now; in addition, to use previous experience in the treatment of COVID-19 by various medicines for severe acute respiratory syndrome coronavirus (SARS-Cov), Middle East Respiratory Symptoms (MERS-CoV), Lupus, Anti-Malarial, Influenza Medicine, etc. were used to combat this disease. Nevertheless, various randomized trials of different drugs underway around the world can be used as a method for tracking the production of CVOID 19 vaccines, and interventions that continue worldwide. However, many vaccines are proposed by an international (privates and governmental bodies) trial against COVID-19. Therefore, the elimination of COVID-19 is an international priority, as the risk of disease will increase with increased death every day without viral spread control. Copyright © 2020 International Journal of Pharmaceutical and Phytopharmacological Research. All rights reserved.
AD  - (Alamoudi, Abdel-Rahman) Biology Department, Faculty of Science, University of Hail, PO Box 2240, Hai'l 81451, Saudi Arabia (Bakrshoom) Medical Department, Faculty of Medicine, University of Hail, PO Box 2240, Hai'l 81451, Saudi Arabia (Bakrshoom) Physical Therapy Department, Faculty of Applied Medicine Science, University of Hail, PO Box 2240, Hai'l 81451, Saudi Arabia (Al-Malky) Regional Drug Information Center, Ministry of Health, Jeddah 21442, Saudi Arabia (Abu Zeid) Department of Biological Sciences, Faculty of Sciences, King Abdulaziz University, PO Box 139109, Jeddah 21323, Saudi Arabia
E.H. Abdel-Rahman, Biology Department, Faculty of Science, University of Hail, PO Box 2240, Hai'l 81451, Saudi Arabia. E-mail: eitimadahmed@yahoo.com
AN  - 2007696745
AU  - Alamoudi, M. O.
AU  - Bakrshoom, Y. F.
AU  - Bakrshoom, S. F.
AU  - Abdel-Rahman, E. H.
AU  - Al-Malky, H. S.
AU  - Abu Zeid, I. M.
C1  - 10/6/2020
DA  - August
DB  - Embase
DP  - Ovid Technologies
IS  - 4
KW  - Antiviral drugs
Applied therapeutics
covid-19
Proposed vaccine
coronavirus disease 2019
drug therapy
histology
histopathology
human
human tissue
infection prevention
influenza
Middle East respiratory syndrome coronavirus
nonhuman
randomized controlled trial (topic)
review
SARS coronavirus
systemic lupus erythematosus
antimalarial agent
antivirus agent
vaccine
LA  - English
M3  - Review
PY  - 2020
SN  - 2250-1029
2249-6084
SP  - 36-43
ST  - Therapeutics and possible vaccine used to treat Covid-19: A Review
T2  - International Journal of Pharmaceutical and Phytopharmacological Research
TI  - Therapeutics and possible vaccine used to treat Covid-19: A Review
UR  - https://eijppr.com/en/article/therapeutics-and-possible-vaccine-used-to-treat-covid-19-a-review
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007696745
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=&issn=2250-1029&isbn=&volume=10&issue=4&spage=36&pages=36-43&date=2020&title=International+Journal+of+Pharmaceutical+and+Phytopharmacological+Research&atitle=Therapeutics+and+possible+vaccine+used+to+treat+Covid-19%3A+A+Review&aulast=Alamoudi&pid=%3Cauthor%3EAlamoudi+M.O.%2CBakrshoom+Y.F.%2CBakrshoom+S.F.%2CAbdel-Rahman+E.H.%2CAl-Malky+H.S.%2CAbu+Zeid+I.M.%3C%2Fauthor%3E&%3CAN%3E2007696745%3C%2FAN%3E&%3CDT%3EReview%3C%2FDT%3E
VL  - 10
ID  - 7782867
ER  - 

TY  - JOUR
AB  - To help investigate the relationship between inflammatory and other symptoms of coronavirus and the protein-protein interactions (PPI) that occur between viral proteins and protein molecules of the host cell, I propose that the electrostatic discharge (ESD) exists including corona discharge to lead to ozone gas. I cite evidence in support of this hypothesis. I hope that the proposed will inspire new studies in finding effective treatments and vaccines for individuals with coronavirus disease in 2019. I suggest possible future studies that may lend more credibility to the proposed.
AD  - College of Science, Technology, Engineering, and Mathematics, University of Arkansas at Little Rock , Little Rock, USA.
AN  - 33016156
AU  - Al Sarkhi, A. K.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1080/15368378.2020.1830794
DP  - NLM
ET  - 2020/10/06
J2  - Electromagnetic biology and medicine
KW  - Coronaviruses
corona discharge method
electrostatic force
ozone gas
protein-protein interactions
LA  - eng
N1  - 1536-8386
Al Sarkhi, Awaad K
Orcid: 0000-0002-2675-2046
Journal Article
England
Electromagn Biol Med. 2020 Oct 3:1-4. doi: 10.1080/15368378.2020.1830794.
PY  - 2020
SN  - 1536-8386
SP  - 1-4
ST  - Hypothesis: The electrical properties of coronavirus
T2  - Electromagnetic biology and medicine
TI  - Hypothesis: The electrical properties of coronavirus
ID  - 7785218
ER  - 

TY  - JOUR
AB  - OBJECTIVES: To identify the changes in rheumatology service delivery across the five regions of Africa from the impact of the COVID-19 pandemic. METHODS: The COVID-19 African Rheumatology Study Group created an online survey consisting of 40 questions relating to the current practices and experiences of rheumatologists across Africa. The CHERRIES checklist for reporting results of internet e-surveys was adhered to. RESULTS: A total of 554 completed responses were received from 20 countries, which include six in Northern Africa, six in West Africa, four in Southern Africa, three in East Africa and one in Central Africa. Consultant grade rheumatologists constituted 436 (78.7%) of respondents with a mean of 14.5 ±�?0.3 years of experience. A total of 77 (13.9%) rheumatologists avoided starting a new biologic. Face-to-face clinics with the use of some personal protective equipment continued to be held in only 293 (52.9%) rheumatologists' practices. Teleconsultation modalities found usage as follows: telephone in 335 (60.5%), WhatsApp in 241 (43.5%), emails in 90 (16.3%) and video calls in 53 (9.6%). Physical examinations were mostly reduced in 295 (53.3%) or done with personal protective equipment in 128 (23.1%) practices. Only 316 (57.0%) reported that the national rheumatology society in their country had produced any recommendation around COVID-19 while only 73 (13.2%) confirmed the availability of a national rheumatology COVID-19 registry in their country. CONCLUSION: COVID-19 has shifted daily rheumatology practices across Africa to more virtual consultations and regional disparities are more apparent in the availability of local protocols and registries.
AD  - Rheumatology Department, Dumfries and Galloway Royal Infirmary, Dumfries, UK.
Internal Medicine Department, University of Uyo Teaching Hospital, Uyo, Nigeria.
Department of Medicine, University of Cape Town, Cape Town, South Africa.
Department of Medicine and Therapeutics, Korle Bu Teaching Hospital, Accra, Ghana.
Department of Paediatrics and Child Health, Aga Khan University, East Africa, Kenya.
Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.
Department of rheumatology, El Ayachi Hospital Medical University, Rabat, Morocco.
Rheumatology and Rehabilitation, Ain Shams University, Cairo, Egypt.
Department of Paediatrics, Batna 2 University, Batna, Algeria.
Kassab Institute of Orthopedics, Tunis El Manar University, Tunis, Tunisia.
Department of Clinical Medicine and Therapeutics, University of Nairobi, Nairobi, Kenya.
Rheumatology, Atlas Clinic of Rheumatology, Batna, Algeria.
Department of Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
Paediatrics Department, Ahmed Gasim Children's Hospital, Khartoum, Sudan.
Faculty of Medicine, Dentistry and Health, University of Sheffield, Sheffield, UK.
Department of Medicine, University of the Witwatersrand, Johannesburg, South Africa.
Rheumatology, Military Hospital, Agadir, Morocco.
Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.
Rheumatology and Rehabilitation, Fayoum University, Fayoum, Egypt.
Paediatrics Department, Mansoura University, Mansoura, Egypt.
Rheumatology and Rehabilitation, Tanta University, Tanta, Egypt.
Rheumatology and Rehabilitation, El Minia University, El Minia, Egypt.
AN  - 33020845
AU  - Akintayo, R. O.
AU  - Akpabio, A. A.
AU  - Kalla, A. A.
AU  - Dey, D.
AU  - Migowa, A. N.
AU  - Olaosebikan, H.
AU  - Bahiri, R.
AU  - El Miedany, Y.
AU  - Hadef, D.
AU  - Hamdi, W.
AU  - Oyoo, O.
AU  - Slimani, S.
AU  - Yerima, A.
AU  - Taha, Y.
AU  - Adebajo, A. O.
AU  - Adelowo, O. O.
AU  - Tikly, M.
AU  - Ghozlani, I.
AU  - Ben Abdelghani, K.
AU  - Fouad, N. A.
AU  - Mosad, D.
AU  - El Mikkawy, D.
AU  - Abu-Zaid, M. H.
AU  - Abdel-Magied, R. A.
C1  - 10/6/2020
DA  - Oct 6
DB  - PubMed
DO  - 10.1093/rheumatology/keaa600
DP  - NLM
ET  - 2020/10/07
J2  - Rheumatology (Oxford, England)
KW  - Africa
Covid-19
Dmard
rheumatic and musculoskeletal diseases
rheumatology
telemedicine
LA  - eng
N1  - 1462-0332
Akintayo, Richard O
Akpabio, Akpabio A
Kalla, Asgar A
Dey, Dzifa
Migowa, Angela N
Olaosebikan, Hakeem
Bahiri, Rachid
El Miedany, Yasser
Hadef, Djohra
Hamdi, Wafa
Oyoo, Omondi
Slimani, Samy
Yerima, Abubakar
Taha, Yassmin
Adebajo, Adewale O
Adelowo, Olufemi O
Tikly, Mohammed
Ghozlani, Imad
Ben Abdelghani, Kawther
Fouad, Nermeen A
Mosad, Doaa
El Mikkawy, Dalia
Abu-Zaid, Mohamed Hassan
Abdel-Magied, Rasha A
Journal Article
England
Rheumatology (Oxford). 2020 Oct 6:keaa600. doi: 10.1093/rheumatology/keaa600.
PY  - 2020
SN  - 1462-0324
ST  - The impact of COVID-19 on rheumatology practice across Africa
T2  - Rheumatology (Oxford, England)
TI  - The impact of COVID-19 on rheumatology practice across Africa
ID  - 7784970
ER  - 

TY  - JOUR
AB  - In this paper, the dynamical behavior of a SEIR epidemic system that takes into account governmental action and individual reaction is investigated. The transmission rate takes into account the impact of governmental action modeled as a step function while the decreasing contacts among individuals responding to the severity of the pandemic is modeled as a decreasing exponential function. We show that the proposed model is capable of predicting Hopf bifurcation points for a wide range of physically realistic parameters for the COVID-19 disease. In this regard, the model predicts periodic behavior that emanates from one Hopf point. The model also predicts stable oscillations connecting two Hopf points. The effect of the different model parameters on the existence of such periodic behavior is numerically investigated. Useful diagrams are constructed that delineate the range of periodic behavior predicted by the model. © 2020, The Author(s).
AD  - Department of Chemical Engineering, King Saud University, Riyadh, Saudi Arabia
Department of Mathematics and Statistics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
AU  - Ajbar, A.
AU  - Alqahtani, R. T.
C1  - 10/6/2020
C7  - 541
DB  - Scopus
DO  - 10.1186/s13662-020-02997-z
IS  - 1
J2  - Adv. Differ. Equations
KW  - Bifurcation
Governmental action
Hopf bifurcation
Individual response
SEIR model
Stability
LA  - English
M3  - Article
N1  - Export Date: 6 October 2020
Correspondence Address: Alqahtani, R.T.; Department of Mathematics and Statistics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU)Saudi Arabia; email: rtalqahtani@imamu.edu.sa
Funding details: Research Center of the College of Computer and Information Sciences, King Saud University, RC CCIS, KSU
Funding text 1: The authors would like to thank the anonymous referees for their valuable suggestions, which have greatly helped in improving the presentation of this paper. The first author would like to thank the Research Center of the College of Engineering at King Saud University, Riyadh, Saudi Arabia, for generous support.
References: Diekmann, O., Heesterbeek, H., Britton, T., (2013) Understanding Infectious Disease Dynamics, , Princeton Series Theoretical and Computational Biology, Princeton University Press, Princeton; Diaz, P., Constantine, P., Kalmbach, K., Jones, E., Pankavich, S., A modified SEIR model for the spread of Ebola in Western Africa and metrics for resource allocation (2018) Appl. Math. Comput., 324, pp. 141-155; Saito, M.M., Imoto, S., Yamaguchi, R., Sato, H., Nakada, H., Kami, M., Miyano, S., Higuchi, T., Extension and verification of the SEIR model on the 2009 influenza A (H1N1) pandemic in Japan (2013) Math. Biosci., 246, pp. 47-54; Etbaigha, F., Willms, R., Poljak, A., An SEIR model of influenza A virus infection and reinfection within a farrow-to-finish swine farm (2018) PLoS ONE, 13 (9); Chang, H.J., Estimation of basic reproduction number of the Middle East respiratory syndrome coronavirus (MERS-CoV) during the outbreak in South Korea, 2015 (2017) Biomed. Eng., 16; Lin, Q., Zhao, S., Gao, D., A conceptual model for the coronavirus disease 2019 (COVID-19) outbreak in Wuhan, China with individual reaction and governmental action (2020) Int. J. Infect. Dis., 93, pp. 211-216; Tang, B., Wang, X., Li, Q., Estimation of the transmission risk of the 2019-nCoV and its implication for public health interventions (2020) J. Clin. Med., 9; Tang, B., Bragazzi, N.L., Li, Q., Tang, S., Xiao, Y., Wu, J., An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov) (2020) Infect. Dis. Model., 5, pp. 248-255; Yang, Z., Zeng, Z., Wang, K., Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions (2020) J. Thorac. Dis., 12, pp. 165-174; Grossman, Z., Oscillatory phenomena in a model of infectious diseases (1980) Theor. Popul. Biol., 18, pp. 204-243; Yi, N., Zhang, Q., Mao, K., Yang, D., Li, Q., Analysis and control of an SEIR epidemic system with nonlinear transmission rate (2009) Math. Comput. Model., 50, pp. 1498-1513; Martcheva, M., (2015) An Introduction to Mathematical Epidemiology, , 1, Springer, Berlin; Hethcote, H.W., van den Driessche, P., Some epidemiological models with nonlinear incidence (1991) J. Math. Biol., 29, pp. 271-287; Abta, A., Laarabi, H., Talibi Alaoui, H., The Hopf bifurcation analysis and optimal control of a delayed sir epidemic model (2014) Int. J. Anal., 2014; Yan, C., Jia, J., Hopf bifurcation of a delayed epidemic model with information variable and limited medical resources (2014) Abstr. Appl. Anal., 2014; Buonomo, B., Chitnis, N., d’Onofrio, A., Seasonality in epidemic models: a literature review (2018) Ric. Mat., 1, pp. 7-25; Olsen, F., Truty, L., Schaffer, W.M., Oscillations and chaos in epidemics: a nonlinear dynamic study of six childhood diseases in Copenhagen, Denmark (1988) Theor. Popul. Biol., 33, pp. 344-370; Earn, J., Rohani, P., Grenfell, B.T., Persistence, chaos and synchrony in ecology and epidemiology (1998) Proc. Biol. Sci., 265, pp. 7-10; Kwuimy, K., Nazari, F., Jiao, X., Rohani, P., Nataraj, C., Nonlinear dynamic analysis of an epidemiological model for COVID-19 including public behavior and government action (2020) Nonlinear Dyn, , To appear; He, D., Dushoff, J., Day, T., Ma, J., Earn, D.J., Inferring the causes of the three waves of the 1918 influenza pandemic in England and Wales (2013) Proc. R. Soc. B, Biol. Sci., 280; Van den Driessche, P., Watmough, J., Reproduction numbers and sub-threshold endemic equilibria for compartmental models of disease transmission (2002) Math. Biosci., 180, pp. 29-48; Douskos, C., Markellos, P., Complete coefficient criteria for five-dimensional Hopf bifurcations, with an application to economic dynamics (2015) J. Nonlinear Dyn., 2015; Ajbar, A., Humaizi, K., (2011) Dynamics of the Chemostat: A Bifurcation Theory Approach, , CRC Press, Boca Raton; Doedel, E.J., Kernevez, J.P., (1986) Auto: Software for Continuation and Bifurcation Problems in Ordinary Differential Equations, , CIT Press, Pasadena
PY  - 2020
SN  - 16871839 (ISSN)
ST  - Bifurcation analysis of a SEIR epidemic system with governmental action and individual reaction
T2  - Advances in Difference Equations
TI  - Bifurcation analysis of a SEIR epidemic system with governmental action and individual reaction
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091720018&doi=10.1186%2fs13662-020-02997-z&partnerID=40&md5=1b352313749371e95b13c7346f1da649
VL  - 2020
ID  - 7783187
ER  - 

TY  - JOUR
AU  - Ahelegbey, Daniel Felix
AU  - Giudici, Paolo
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Centrality, COVID-19, Financial Crises, NetVIX, Turbulence, VAR, VIX
PY  - 2020
ST  - NetVIX - A Network Volatility Index of Financial Markets (preprint)
T2  - SSRN
TI  - NetVIX - A Network Volatility Index of Financial Markets (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3693806
ID  - 7788904
ER  - 

TY  - JOUR
AB  - The etiological agent of coronavirus disease-19 (COVID-19), SARS-coronavirus-2 (SARS-CoV-2), emerged in Wuhan, China, and quickly spread worldwide leading the World Health Organization (WHO) to recognize it not only as a pandemic but also as an important thread to public health. Beyond respiratory symptoms, new neurological manifestations are being identified such as headache, ageusia, anosmia, encephalitis or acute cerebrovascular disease. Here we report the case of an acute transverse myelitis (TM) in a patient with SARS-CoV-2 infection detected by the nasopharyngeal swab technique but not in cerebrospinal fluid (CSF) analysis. Anti-herpes simplex virus (HSV) 1 and varicella-zoster IgM antibodies were not detected in serum samples and spinal and brain magnetic resonance imaging (MRI) showed no abnormal findings. This case remarks that COVID-19 nervous system damage could be caused by immune-mediated mechanisms. Copyright © 2020 Elsevier Ltd
AD  - (Aguila-Gordo) Cardiology Department, University Hospital of Ciudad Real, Obispo Torija s/n, Ciudad Real 13005, Spain (Manuel Flores-Barragan) Neurology Service of Hospital General de Ciudad Real, Spain (Ferragut-Lloret, Portela-Gutierrez, Carlos Villa Guzman) Oncology Service of Hospital General de Ciudad Real, Spain (LaRosa-Salas, Porras-Leal) Internal Medicine of Hospital General de Ciudad Real, Spain
AN  - 2007958710
AU  - Aguila-Gordo, D.
AU  - Manuel Flores-Barragan, J.
AU  - Ferragut-Lloret, F.
AU  - Portela-Gutierrez, J.
AU  - LaRosa-Salas, B.
AU  - Porras-Leal, L.
AU  - Carlos Villa Guzman, J.
C1  - 10/6/2020
DA  - October
DB  - Embase
DO  - http://dx.doi.org/10.1016/j.jocn.2020.07.074
DP  - Ovid Technologies
KW  - Acute transverse myelitis
covid-19
Neurological symptoms
SARS-CoV-2
adult
article
brain
case report
cerebrospinal fluid analysis
clinical article
coronavirus disease 2019
female
human
Human alphaherpesvirus 1
human tissue
male
myelitis
nonhuman
nuclear magnetic resonance imaging
Varicella zoster virus
immunoglobulin M antibody
LA  - English
PY  - 2020
SN  - 0967-5868
1532-2653
SP  - 280-281
ST  - Acute myelitis and SARS-CoV-2 infection. A new etiology of myelitis?
T2  - Journal of Clinical Neuroscience
TI  - Acute myelitis and SARS-CoV-2 infection. A new etiology of myelitis?
UR  - http://www.elsevier.com/inca/publications/store/6/2/3/0/5/6/index.htt
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&D=emedx&AN=2007958710
http://sfx.library.cdc.gov/cdc?sid=OVID:embase&id=pmid:&id=10.1016%2Fj.jocn.2020.07.074&issn=0967-5868&isbn=&volume=80&issue=&spage=280&pages=280-281&date=2020&title=Journal+of+Clinical+Neuroscience&atitle=Acute+myelitis+and+SARS-CoV-2+infection.+A+new+etiology+of+myelitis%3F&aulast=Aguila-Gordo&pid=%3Cauthor%3EAguila-Gordo+D.%2CManuel+Flores-Barragan+J.%2CFerragut-Lloret+F.%2CPortela-Gutierrez+J.%2CLaRosa-Salas+B.%2CPorras-Leal+L.%2CCarlos+Villa+Guzman+J.%3C%2Fauthor%3E&%3CAN%3E2007958710%3C%2FAN%3E&%3CDT%3EArticle%3C%2FDT%3E
VL  - 80
ID  - 7782815
ER  - 

TY  - JOUR
AB  - PURPOSE: To evaluate the change in the ongoing immunomodulatory (IMT) and biological therapies among patients with non-infectious uveitis (NIU), and determine the number of uveitis relapses during the COVID-19 pandemic. METHODS: In this national multicentric prospective case series, data of subjects with NIU receiving corticosteroids, systemic IMT and/or biological agents were analysed. The data collection was performed from 1 March 2020 to 25 June 2020. Main outcome measures included change in the ongoing treatments with corticosteroids, IMT and biological agents, use of alternate therapies and rates of uveitis relapse. RESULTS: In this study, 176 patients (284 eyes) with NIU (mean age: 33�u17.1 years; males: 68) were included. A total of 121 eyes (90 patients) were deemed to have active NIU. Of these, seven subjects (7.8%) did not receive intravenous methylprednisolone despite need felt by the treating uveitis experts. In addition, 35 subjects (57.4%) received a rapid tapering dosage of oral corticosteroids despite active disease. A total of 161 (91.5%) subjects were receiving systemic IMT and 25 (14.2%) were on biological therapies. Overall, IMT was altered in 29/161 (18.0%) subjects. Twenty-two eyes were treated with intravitreal therapies in the study period. Fifty-three eyes (32.5%, 29 subjects) developed relapse of NIU, of which 25 subjects (86.2%) were deemed to have reactivation related to altered systemic IMT. No patient developed COVID-19 during follow-up. CONCLUSIONS: During the ongoing COVID-19 pandemic, uveitis specialists may tend to reduce the ongoing systemic IMT, or prefer less aggressive treatment strategies for NIU. These subjects may be at high risk of relapse of uveitis.
AD  - Advanced Eye Center, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Department of Uvea, Medical and Vision Research Foundation, Sankara Nethralaya, Chennai, India.
Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India.
Department of Ophthalmology, Vittala International Institute of Ophthalmology, Bengaluru, India.
Department of Vitreo-Retina, Shri Sadguru Seva Sangh Trust Chitrakoot Centre, Chitrakoot, India.
Department of Vitreo-Retina, Dr. Shroff's Charity Eye Hospital Delhi, New Delhi, India.
Uvea Services, Aravind Eye Hospital Care System, Pondicherry, India.
Department of Ophthalmology, Tan Tock Seng Hospital, Singapore, Singapore.
Advanced Eye Center, Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India vishalisara@yahoo.co.in vishalisara@gmail.com.
AN  - 33011688
AU  - Agarwal, A. K.
AU  - Sudharshan, S.
AU  - Mahendradas, P.
AU  - Babu, K.
AU  - Shenoy, P.
AU  - Dogra, M.
AU  - Bansal, R.
AU  - Agarwal, M.
AU  - Biswas, J.
AU  - Balamurugan, S.
AU  - Agrawal, R.
AU  - Gupta, V.
C1  - 10/6/2020
DA  - Oct 3
DB  - PubMed
DO  - 10.1136/bjophthalmol-2020-317417
DP  - NLM
ET  - 2020/10/05
J2  - The British journal of ophthalmology
KW  - Immunology
Infection
Inflammation
LA  - eng
N1  - 1468-2079
Agarwal, Aniruddha Kishandutt
Sudharshan, Sridharan
Mahendradas, Padmamalini
Babu, Kalpana
Shenoy, Pratik
Dogra, Mohit
Bansal, Reema
Agarwal, Manisha
Biswas, Jyotirmay
Orcid: 0000-0003-1214-5429
Balamurugan, S
Agrawal, Rupesh
Gupta, Vishali
Orcid: 0000-0001-8216-4620
Journal Article
England
Br J Ophthalmol. 2020 Oct 3:bjophthalmol-2020-317417. doi: 10.1136/bjophthalmol-2020-317417.
PY  - 2020
SN  - 0007-1161
ST  - Impact of COVID-19 pandemic on uveitis patients receiving immunomodulatory and biological therapies (COPE STUDY)
T2  - British journal of ophthalmology
TI  - Impact of COVID-19 pandemic on uveitis patients receiving immunomodulatory and biological therapies (COPE STUDY)
ID  - 7785664
ER  - 

TY  - JOUR
AB  - INTRODUCTION: Smoking causes inflammation of the lung epithelium by releasing cytokines and impairing mucociliary clearance. Some studies have linked smoking with severity of illness of COVID-19 whereas others have found no such association. METHODS: This was a retrospective analysis of all adults hospitalised with COVID-19 from 9 March to 18 May 2020. RESULTS: 1173 patients met the study criteria. 837 patients never smoked whereas 336 patients were either current smokers or past smoker and were grouped together in smokers group. Patients in smokers group were more likely to be male and had higher incidence of underlying chronic obstructive pulmonary disease (19% vs 6%, p0.001), HIV infection (11% vs 5%,p0.001), cancer (11% vs 6%, p=0.005), congestive heart failure (15% vs 8%, p0.001), coronary artery disease (15% vs 9%, p=0.3), chronic kidney disease (11% vs 8%, p=0.037) and end-stage renal disease (10% vs 6%, p=0.009) compared with non-smokers. Outcome analysis showed that smokers were more likely to develop critical illness requiring mechanical ventilation (47% vs 37% p=0.005). Univariate Cox model for survival analysis by smoking status showed that among smokers only current smokers had higher risk of death compared with never smokers (HR 1.61, 95% CI 1.22 to 2.12, p0.001). In the multivariate approach, Cox model for the survival, female sex, young age, low serum lactate dehydrogenase and systemic steroid use were associated with overall improved survival. CONCLUSION: In our large single-centre retrospective database of patients hospitalised with COVID-19, smoking was associated with development of critical illness and higher likelihood of death.
AD  - Department of Medicine, Bronx Care Health System, Bronx, New York, USA aadrish@hotmail.com.
Department of Medicine, Bronx Care Health System, Bronx, New York, USA.
Attending Pulmonary & Critical Care, Department of Medicine, Bronx Care Health System, Bronx, New York, USA.
AN  - 33020114
AU  - Adrish, M.
AU  - Chilimuri, S.
AU  - Mantri, N.
AU  - Sun, H.
AU  - Zahid, M.
AU  - Gongati, S.
AU  - Fortuzi, K.
AU  - Jog, A. P.
AU  - Purmessur, P.
AU  - Singhal, R.
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1136/bmjresp-2020-000716
DP  - NLM
ET  - 2020/10/07
IS  - 1
J2  - BMJ open respiratory research
KW  - respiratory infection
LA  - eng
N1  - 2052-4439
Adrish, Muhammad
Orcid: 0000-0002-5553-6182
Chilimuri, Sridhar
Mantri, Nikhitha
Sun, Haozhe
Zahid, Maleeha
Gongati, Sudharsan
Fortuzi, Ked
Jog, Abhishrut Pramod
Purmessur, Pravish
Singhal, Ravish
Journal Article
England
BMJ Open Respir Res. 2020 Oct;7(1):e000716. doi: 10.1136/bmjresp-2020-000716.
PY  - 2020
SN  - 2052-4439
ST  - Association of smoking status with outcomes in hospitalised patients with COVID-19
T2  - BMJ open respiratory research
TI  - Association of smoking status with outcomes in hospitalised patients with COVID-19
VL  - 7
ID  - 7785051
ER  - 

TY  - JOUR
AB  - In the clinical daily work of psychiatry, the question regularly arises under which legal conditions patients who are not able to form free will due to a mental illness should be treated in case of an additional suspicion of a SARS-CoV-2 infection or with a confirmed Covid-19 disease. However, physicians may be uncertain about the legal basis for coercive measures during the corona pandemic: when and under which legal conditions such measures are required. This article presents and discusses in detail the legal regulations currently applicable in Germany.
AU  - Adorjan, Kristina
AU  - Gaudernack, Dorothea
AU  - Beer, Julia
AU  - von Massenbach, Christine
AU  - Falkai, Peter
AU  - Pollmächer, Thomas
AU  - Pogarell, Oliver
C1  - 10/6/2020
DA  - 2020/10
DB  - MEDLINE
DP  - https://www.who.int/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/
LA  - de
PY  - 2020
ST  - Zwangsmaßnahmen und die SARS-CoV-2-Pandemie
T2  - Nervenarzt
TI  - Zwangsmaßnahmen und die SARS-CoV-2-Pandemie
TT  - [Coercive measures and the SARS-CoV-2 pandemic].
UR  - https://dx.doi.org/10.1007/s00115-020-01002-y
ID  - 7788503
ER  - 

TY  - JOUR
AB  - The COVID-19 pandemic resulted in more than 4.3 million confirmed cases and more than 2,90,000 deaths worldwide. It has also given rise to fears of an imminent economic crisis and recession. Social distance, self-isolation, and travel restrictions have led to a reduction in the workforce across all economical sectors and have led to a loss of many jobs. Schools have closed down, and the need for commodities and manufactured goods has decreased. On the other hand, the need for medical supplies has increased significantly. The food sector is also facing increased demand as a result of panic buying and storing food products. In response to this global outbreak, we summarize the socioeconomic effects of COVID-19 on the various aspects of the world economy. In Malaysia, the COVID-19 epidemic has checked the resilience of the agriculture sector. Especially the Malaysian paddy industry as country imports 30% of its overall consumption from different parts of the world. The real price of rice triplicating for the consumers, which was alarming for nations in this pandemic situation. The Government of Malaysia introduced the National Agrofood Policy 2011�?020 (NAP4) in 2010 as a guidance document for the implementation of agricultural sector development programs and projects in Malaysia. The NAP4 ‘s 10-year term is to be finished by the end of 2020. Several sectors demonstrate substantial success after approximately 8 years of introduction, while the other classes often lag behind the goal and progress quite slowly. Agricultural sector performance is affected by many problems and challenges. In acknowledgment of the poor success of this field, the Ministry of Agriculture and Agri-Based Industry has launched new approaches, policies, and programs that can change the agricultural sector more rapidly. The new direction is aimed at ensuring national food security and boosting farm and revenues. The authorized government agency needs to revise the policy formulation where Malaysia needs to set stages to revolutionize and modernize the rice farming to address the problem faced by the paddy sector in this pandemic situation to adopt GF. In this study, the researcher focuses on the improvisation of the policy to increase the paddy production sustainably. © 2020, Springer Nature B.V.
AD  - Universiti Teknologi Petronas, Seri Iskandar, Malaysia
AU  - Adnan, N.
AU  - Nordin, S. M.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.1007/s10668-020-00978-6
J2  - Environ. Dev. Sustainability
KW  - COVID19
GF
Malaysian paddy farmers
Sustainable agricultural practices
LA  - English
M3  - Review
N1  - Export Date: 6 October 2020
CODEN: EDSNB
Correspondence Address: Adnan, N.; Universiti Teknologi PetronasMalaysia; email: Nadia.adnan233@gmail.com
Funding text 1: Researcher would like to thank Universiti teknologi Petronas and Management & Humanities Department. Furthermore, researcher would like to acknowledge LRGS and YUTP grant for their financial support.
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PY  - 2020
SN  - 1387585X (ISSN)
ST  - How COVID 19 effect Malaysian paddy industry? Adoption of green fertilizer a potential resolution
T2  - Environment, Development and Sustainability
TI  - How COVID 19 effect Malaysian paddy industry? Adoption of green fertilizer a potential resolution
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091725631&doi=10.1007%2fs10668-020-00978-6&partnerID=40&md5=a21dcacaf28248fa90864e0d7e994a70
ID  - 7783271
ER  - 

TY  - JOUR
AU  - Abubakar, Jamaladeen
C1  - 10/6/2020
DB  - SSRN
DP  - SSRN
KW  - Regime Switching, Skew-Normal, Contagion, Africa
PY  - 2020
ST  - A Regime Switching Skew-Normal Model of Contagion in Major African Stock Markets (preprint)
T2  - SSRN
TI  - A Regime Switching Skew-Normal Model of Contagion in Major African Stock Markets (preprint)
UR  - https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3675415
ID  - 7788911
ER  - 

TY  - JOUR
AD  - Northwell Health, Health Solutions, Manhasset, New York, USA.
Department of Emergency Medicine, Northwell Health, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
AN  - 33020899
AU  - Abrashkin, K. A.
AU  - Poku, A.
AU  - Ball, T.
AU  - Brown, Z. J.
AU  - Rhodes, K. V.
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1111/jgs.16857
DP  - NLM
ET  - 2020/10/07
J2  - Journal of the American Geriatrics Society
LA  - eng
N1  - 1532-5415
Abrashkin, Karen A
Orcid: 0000-0002-9864-8707
Poku, Asantewaa
Ball, Trever
Brown, Zenobia J
Rhodes, Karin V
Letter
United States
J Am Geriatr Soc. 2020 Oct 5. doi: 10.1111/jgs.16857.
PY  - 2020
SN  - 0002-8614
ST  - Ready or Not: Pivoting to Video Visits with Homebound Older Adults During the COVID-19 Pandemic
T2  - Journal of American Geriatrics Society
TI  - Ready or Not: Pivoting to Video Visits with Homebound Older Adults During the COVID-19 Pandemic
ID  - 7784969
ER  - 

TY  - JOUR
AB  - The pandemic of Coronavirus Disease 2019 forms a big threat to all people in the world around us. In Iraq, there is a direct increase in the incidence, with a slight decrease in the mortality rate, and that leads us to attempt to find any way to stop or lessen the virus's harmful symptoms. In the current study, we used molecular docking to detect the probable inhibitory effect of fifteen natural compounds of some Flavonoids and their derivatives and two antiviral drugs against two of very important SARS-COV-2 proteins the papain like protease (PLpro) and RNA dependent RNA polymerase (RdRp) that was performed using Molecular Operating Environment software(MOE). All the chosen flavonoids and their derivatives, plus the two antiviral drugs docked in the active sites of the viral proteins (PLpro), some of the natural flavonoids like Glycitein 7-O-glucuronide and Theaflavin, gives energy complex scores about-6.96308947 and-6.99058199 Kcal/mol which is better than the energy score is given by Sofosbuvir and Darunavir-6.81020832 and-6.93942785 Kcal/mol respectively. And the docking of the compounds into the active sites of (RdRp) protein gives energy binding scores for Theaflavin monogallate-7.84163618 kcal/mol and that better than the complex's score given by docking of the Sofosbuvir and Darunavir into the same protein which gives-7.30999422 and-7.67598867 kcal/mol respectively. That’s mean these flavonoids and their derivatives can be used as COVID-19 treatment. Otherwise, the infected people with COVID-19 can consume food rich with these Flavonoids to inhibit the virus or at least decrease its symptoms. Also from docking of flavonoids into both viral proteins, we can notice that all-natural compounds reported energy binding scores, and the Flavonoid derivatives have a better energy binding score than flavonoid themselves. © 2020, Advanced Scientific Research. All rights reserved.
AD  - Department of Clinical Laboratory Sciences, College of Pharmacy, University of Basra, Iraq
Department of Pharmacognosy and medicinal plants, College of Pharmacy, University of Basra, Iraq
AU  - Abdul-Jabar, R. A.
AU  - Al-Fadal, S. A. M.
C1  - 10/6/2020
DB  - Scopus
DO  - 10.31838/ijpr/2020.12.02.360
IS  - 2
J2  - Int. J. Pharm. Res.
KW  - 6WX4
7BV2
Flavonoid derivatives
Flavonoids
Papain like protease
RdRp
Theaflavin
LA  - English
M3  - Note
N1  - Export Date: 6 October 2020
Correspondence Address: Al-Fadal, S.A.M.; Department of Pharmacognosy and medicinal plants, College of Pharmacy, University of BasraIraq; email: sabaal.fadal@gmail.com
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PY  - 2020
SN  - 09752366 (ISSN)
SP  - 2668-2686
ST  - In-silico study of the inhibitory effect of some flavonoids compounds and their derivatives on SARSCOV-2
T2  - International Journal of Pharmaceutical Research
TI  - In-silico study of the inhibitory effect of some flavonoids compounds and their derivatives on SARSCOV-2
UR  - https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091720686&doi=10.31838%2fijpr%2f2020.12.02.360&partnerID=40&md5=4f3394e9f75824bb97184087eb32214e
VL  - 12
ID  - 7783223
ER  - 

TY  - JOUR
AB  - Hamad General Hospital Anticoagulation Clinic is one of the largest collaborative-practice clinics of its type in Qatar. The patients being followed at this clinic are typically complex and vulnerable. During the coronavirus disease 2019 pandemic, measures were implemented at the clinic to minimize the exposure of patients and healthcare providers to the acute respiratory syndrome coronavirus-2 and to promote social distancing. These measures included extending INR-recall period, transitioning to direct oral anticoagulant drugs whenever feasible, home visits to elderly and immunocompromised patients for INR testing, establishing an anticoagulation hotline, and relocation of warfarin dispensing from the main pharmacy to the anticoagulation clinic. In addition, the clinic shifted its multidisciplinary team meetings onto an online platform using Microsoft Teams. Telehealth consultations were extensively utilized to closely follow up with the patients and ensure that anticoagulation efficacy and safety remained optimal. The aim of this paper is to share our experience and describe the measures adopted by the clinic as part of the Hamad Medical Corporation response to the emerging situation.
AD  - Clinical Pharmacy Department, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Clinical Pharmacy Department, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar. aabdulrahman@hamad.qa.
Hematology Department, National Center for Cancer Care and Research, Hamad Medical Corporation, Doha, Qatar.
Weill Cornell Medicine, Doha, Qatar.
Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
AN  - 33015725
AU  - Abdallah, I.
AU  - Eltahir, A.
AU  - Fernyhough, L.
AU  - El-Bardissy, A.
AU  - Ahmed, R.
AU  - Abdulgelil, M.
AU  - Elgaily, D.
AU  - Mohammed, A.
AU  - Jassim, A.
AU  - Barakat, L.
AU  - Al-Ansari, M.
AU  - Javed, M.
AU  - Alkhawaja, R.
AU  - Elzouki, A. N.
C1  - 10/6/2020
DA  - Oct 4
DB  - PubMed
DO  - 10.1007/s11239-020-02276-4
DP  - NLM
ET  - 2020/10/06
J2  - Journal of thrombosis and thrombolysis
KW  - Anticoagulation
Covid-19
Clinical pharmacy
Collaborative practice
Social distancing
Warfarin
LA  - eng
N1  - 1573-742x
Abdallah, Ibtihal
Eltahir, Asma
Orcid: 0000-0001-5593-0465
Fernyhough, Liam
El-Bardissy, Ahmed
Ahmed, Rana
Abdulgelil, Mohammed
Elgaily, Dina
Mohammed, AbdulMoqeeth
Jassim, Ameena
Barakat, Loluwa
Al-Ansari, Mazen
Javed, Mehak
Alkhawaja, Raja
Elzouki, Abdel-Nasser
Journal Article
Netherlands
J Thromb Thrombolysis. 2020 Oct 4. doi: 10.1007/s11239-020-02276-4.
PY  - 2020
SN  - 0929-5305
ST  - The experience of Hamad General Hospital collaborative anticoagulation clinic in Qatar during the COVID-19 pandemic
T2  - Journal of thrombosis and thrombolysis
TI  - The experience of Hamad General Hospital collaborative anticoagulation clinic in Qatar during the COVID-19 pandemic
ID  - 7785254
ER  - 

TY  - JOUR
AN  - 33012393
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.annemergmed.2020.06.015
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Annals of emergency medicine
LA  - eng
N1  - 1097-6760
Editorial
United States
Ann Emerg Med. 2020 Oct;76(4):e69-e70. doi: 10.1016/j.annemergmed.2020.06.015. Epub 2020 Jun 8.
PY  - 2020
SN  - 0196-0644
SP  - e69-e70
ST  - Care of Patients With Behavioral Health Emergencies and Suspected or Confirmed COVID-19
T2  - Annals of emergency medicine
TI  - Care of Patients With Behavioral Health Emergencies and Suspected or Confirmed COVID-19
VL  - 76
ID  - 7785581
ER  - 

TY  - JOUR
AN  - 33012394
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.annemergmed.2020.06.016
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Annals of emergency medicine
LA  - eng
N1  - 1097-6760
Editorial
United States
Ann Emerg Med. 2020 Oct;76(4):e71. doi: 10.1016/j.annemergmed.2020.06.016. Epub 2020 Jun 8.
PY  - 2020
SN  - 0196-0644
SP  - e71
ST  - COVID-19 Personal Protective Equipment During the Pandemic
T2  - Annals of emergency medicine
TI  - COVID-19 Personal Protective Equipment During the Pandemic
VL  - 76
ID  - 7785580
ER  - 

TY  - JOUR
AN  - 33012395
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.annemergmed.2020.06.013
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Annals of emergency medicine
LA  - eng
N1  - 1097-6760
Editorial
United States
Ann Emerg Med. 2020 Oct;76(4):e73. doi: 10.1016/j.annemergmed.2020.06.013. Epub 2020 Jun 8.
PY  - 2020
SN  - 0196-0644
SP  - e73
ST  - COVID-19: Use of Donated or Self-purchased Personal Protective Equipment
T2  - Annals of emergency medicine
TI  - COVID-19: Use of Donated or Self-purchased Personal Protective Equipment
VL  - 76
ID  - 7785579
ER  - 

TY  - JOUR
AN  - 33012406
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1016/j.annemergmed.2020.06.004
DP  - NLM
ET  - 2020/10/06
IS  - 4
J2  - Annals of emergency medicine
LA  - eng
N1  - 1097-6760
Editorial
United States
Ann Emerg Med. 2020 Oct;76(4):e95-e97. doi: 10.1016/j.annemergmed.2020.06.004. Epub 2020 Jun 7.
PY  - 2020
SN  - 0196-0644
SP  - e95-e97
ST  - ACEP Guideline on COVID-19: Ultrasound Machine and Transducer Cleaning
T2  - Annals of emergency medicine
TI  - ACEP Guideline on COVID-19: Ultrasound Machine and Transducer Cleaning
VL  - 76
ID  - 7785578
ER  - 

TY  - JOUR
AN  - 33017238
C1  - 10/6/2020
DA  - Oct
DB  - PubMed
DO  - 10.1377/hlthaff.2020.01653
DP  - NLM
ET  - 2020/10/06
IS  - 10
J2  - Health affairs (Project Hope)
LA  - eng
N1  - 1544-5208
News
United States
Health Aff (Millwood). 2020 Oct;39(10):1837-1838. doi: 10.1377/hlthaff.2020.01653.
PY  - 2020
SN  - 0278-2715
SP  - 1837-1838
ST  - Funding Children's Health: COVID-19 And Beyond
T2  - Health affairs (Project Hope)
TI  - Funding Children's Health: COVID-19 And Beyond
VL  - 39
ID  - 7785149
ER  - 

TY  - JOUR
AN  - 33020120
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1136/archdischild-2020-320652
DP  - NLM
ET  - 2020/10/07
J2  - Archives of disease in childhood
KW  - epidemiology
health services research
virology
LA  - eng
N1  - 1468-2044
International Child Health Group
Royal College of Paediatrics & Child Health
Royal College of Paediatrics & Child Hea
Journal Article
Review
England
Arch Dis Child. 2020 Oct 5:archdischild-2020-320652. doi: 10.1136/archdischild-2020-320652.
PY  - 2020
SN  - 0003-9888
ST  - Impact of the COVID-19 pandemic on global child health: joint statement of the International Child Health Group and the Royal College of Paediatrics and Child Health
T2  - Archives of disease in childhood
TI  - Impact of the COVID-19 pandemic on global child health: joint statement of the International Child Health Group and the Royal College of Paediatrics and Child Health
ID  - 7785050
ER  - 

TY  - JOUR
AN  - 33020309
C1  - 10/6/2020
DA  - Oct 5
DB  - PubMed
DO  - 10.1073/pnas.2018637117
DP  - NLM
ET  - 2020/10/07
J2  - Proceedings of the National Academy of Sciences of the United States of America
LA  - eng
N1  - 1091-6490
Journal Article
Published Erratum
United States
Proc Natl Acad Sci U S A. 2020 Oct 5:202018637. doi: 10.1073/pnas.2018637117.
PY  - 2020
SN  - 0027-8424
ST  - Correction for Zhang et al., Identifying airborne transmission as the dominant route for the spread of COVID-19
T2  - Proceedings of National Academy of Sciences of United States of America
TI  - Correction for Zhang et al., Identifying airborne transmission as the dominant route for the spread of COVID-19
ID  - 7785040
ER  - 

TY  - JOUR
AN  - 33020749
C1  - 10/6/2020
C2  - PMC7527190
DA  - Sep
DB  - PubMed
DO  - 10.1016/j.eclinm.2020.100586
DP  - NLM
ET  - 2020/10/07
J2  - EClinicalMedicine
LA  - eng
N1  - 2589-5370
Editorial
England
EClinicalMedicine. 2020 Sep;26:100586. doi: 10.1016/j.eclinm.2020.100586. Epub 2020 Sep 30.
PY  - 2020
SN  - 2589-5370
SP  - 100586
ST  - Understanding the long-term health effects of COVID-19
T2  - EClinicalMedicine
TI  - Understanding the long-term health effects of COVID-19
VL  - 26
ID  - 7784980
ER  - 

TY  - JOUR
AB  - Chung Jin Chung, legal counsel at Korea Gas Corporation in Seoul, shares insights for companies in Korea and beyond
AN  - 2448229952
C1  - 10/6/2020
DA  - 2020 Sep 02
2020-10-05
DB  - ProQuest Central
DP  - ProQuest Central
KW  - Law--International Law
Liquidated damages
Industrial accidents
Coronaviruses
Construction contracts
State laws
Hotels & motels
COVID-19
Contractors
New York
LA  - English
N1  - Copyright - Copyright Euromoney Institutional Investor PLC Sep 2, 2020
SubjectsTermNotLitGenreText - New York
PY  - 2020
SN  - 02626969
ST  - Practical tips for companies in applying force majeure
T2  - International Financial Law Review
TI  - Practical tips for companies in applying force majeure
UR  - https://www.proquest.com/docview/2448229952?accountid=26724
http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQ:ProQ%3Aabiglobal&atitle=Practical+tips+for+companies+in+applying+force+majeure&title=International+Financial+Law+Review&issn=02626969&date=2020-09-02&volume=&issue=&spage=&au=&isbn=&jtitle=International+Financial+Law+Review&btitle=&rft_id=info:eric/&rft_id=info:doi/
ID  - 7784892
ER  - 

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